Jaguars vs. 49ers
Prediction, Odds & Props
Sep 28 | NFL AI Picks
Updated: 2025-09-21T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 28, 2025
Start Time: 4:05 PM EST​
Venue: ​
49ers Record:
Jaguars Record:
OPENING ODDS
JAX Moneyline:
SF Moneyline:
JAX Spread: 0
SF Spread:
Over/Under:
JAX
Betting Trends
SF
Betting Trends
MATCHUP TRENDS
JAX vs. SF
Best Prop Bet
LIVE NFL ODDS
NFL ODDS COMPARISON
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Jacksonville vs San Francisco Prediction & Odds:
Free NFL Betting Insights for 9/28/25
Jacksonville Jaguars NFL Preview
Credit: USA TODAY/IMAGN
San Francisco 49ers NFL Preview
Jacksonville vs. San Francisco Prop Picks (AI)
Jacksonville vs. San Francisco Prediction (AI)
Remi, our AI sports genius, has been pouring over tons of data from every angle between the Jaguars and 49ers and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.
Interestingly enough, the data has been most focused on the linear correlation of emphasis knucklehead sportsbettors regularly put on San Francisco’s strength factors between a Jaguars team going up against a possibly rested 49ers team. It appears the true game analytics might reflect a moderate lean against one Vegas line in particular.
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Below is our current AI Jacksonville vs San Francisco picks, computer picks Jaguars vs 49ers, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
|---|---|---|---|---|---|---|
| NFL | 9/18 | MIA@BUF | UNLOCK THIS PICK | 6 |
VAULT v3
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| NFL | 9/18 | MIA@BUF | UNLOCK THIS PICK | 1 |
INTEL
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| NFL | 9/18 | MIA@BUF | GET FREE PICK NOW | 1 | – | |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number.
Jaguars Betting Trends
49ers Betting Trends
Jaguars vs. 49ers Matchup Trends
Jacksonville vs. San Francisco Game Info
What time does Jacksonville vs San Francisco start on September 28, 2025?
Jacksonville vs San Francisco starts on September 28, 2025 at 4:05 PM EST.
What are the opening odds for Jacksonville vs San Francisco?
Spread: San Francisco
Moneyline: Jacksonville , San Francisco
Over/Under:
What are the records for Jacksonville vs San Francisco?
Jacksonville: Â |Â San Francisco:
What is the AI best bet for Jacksonville vs San Francisco?
. Prices move—always shop for the best number.
What are Jacksonville trending bets?
JAX trend:
What are San Francisco trending bets?
SF trend:
Where can I find AI Picks for Jacksonville vs San Francisco?
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Jacksonville vs. San Francisco Odds
Remi is pouring through mountains of stats on each line. In fact, anytime the Jacksonville vs San Francisco trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance rarely follow normal, predictable betting trends.
Jacksonville vs San Francisco Opening Odds
JAX Moneyline:
SF Moneyline:
JAX Spread: 0
SF Spread:
Over/Under:
Jacksonville vs San Francisco Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Sep 21, 2025 1:00PM EDT
New York Jets
Tampa Bay Buccaneers
9/21/25 1PM
Jets
Buccaneers
|
–
–
|
+255
-345
|
+6.5 (-110)
-6.5 (-115)
|
O 43.5 (-113)
U 43.5 (-113)
|
|
|
Sep 21, 2025 1:00PM EDT
Las Vegas Raiders
Washington Commanders
9/21/25 1PM
Raiders
Commanders
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–
–
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+143
-186
|
+3.5 (-115)
-3.5 (-110)
|
O 44 (-115)
U 44 (-110)
|
|
|
Sep 21, 2025 1:00PM EDT
Atlanta Falcons
Carolina Panthers
9/21/25 1PM
Falcons
Panthers
|
–
–
|
-250
+195
|
-5.5 (-114)
+5.5 (-112)
|
O 43.5 (-112)
U 43.5 (-113)
|
|
|
Sep 21, 2025 1:00PM EDT
Green Bay Packers
Cleveland Browns
9/21/25 1PM
Packers
Browns
|
–
–
|
-480
+330
|
-8 (-110)
+8 (-115)
|
O 41.5 (-113)
U 41.5 (-113)
|
|
|
Sep 21, 2025 1:00PM EDT
Houston Texans
Jacksonville Jaguars
9/21/25 1PM
Texans
Jaguars
|
–
–
|
+100
-125
|
+1.5 (-113)
-1.5 (-113)
|
O 44 (-112)
U 44 (-114)
|
|
|
Sep 21, 2025 1:00PM EDT
Pittsburgh Steelers
New England Patriots
9/21/25 1PM
Steelers
Patriots
|
–
–
|
-125
+100
|
-1.5 (-113)
+1.5 (-113)
|
O 44.5 (-112)
U 44.5 (-114)
|
|
|
Sep 21, 2025 1:00PM EDT
Cincinnati Bengals
Minnesota Vikings
9/21/25 1PM
Bengals
Vikings
|
–
–
|
+120
-152
|
+3 (-117)
-3 (-108)
|
O 42 (-114)
U 42 (-112)
|
|
|
Sep 21, 2025 1:01PM EDT
Los Angeles Rams
Philadelphia Eagles
9/21/25 1:01PM
Rams
Eagles
|
–
–
|
+155
-195
|
+3.5 (-120)
-3.5 (-107)
|
O 44.5 (-113)
U 44.5 (-113)
|
|
|
Sep 21, 2025 1:01PM EDT
Indianapolis Colts
Tennessee Titans
9/21/25 1:01PM
Colts
Titans
|
–
–
|
-215
+165
|
-4 (-113)
+4 (-113)
|
O 43.5 (-114)
U 43.5 (-112)
|
|
|
Sep 21, 2025 4:05PM EDT
Denver Broncos
Los Angeles Chargers
9/21/25 4:05PM
Broncos
Chargers
|
–
–
|
+120
-150
|
+2.5 (-109)
-2.5 (-115)
|
O 45.5 (-112)
U 45.5 (-114)
|
|
|
Sep 21, 2025 4:05PM EDT
New Orleans Saints
Seattle Seahawks
9/21/25 4:05PM
Saints
Seahawks
|
–
–
|
+295
-420
|
+7.5 (-117)
-7.5 (-109)
|
O 41.5 (-114)
U 41.5 (-112)
|
|
|
Sep 21, 2025 4:25PM EDT
Dallas Cowboys
Chicago Bears
9/21/25 4:25PM
Cowboys
Bears
|
–
–
|
-114
-110
|
pk
pk
|
O 50.5 (-112)
U 50.5 (-114)
|
|
|
Sep 21, 2025 4:26PM EDT
Arizona Cardinals
San Francisco 49ers
9/21/25 4:26PM
Cardinals
49ers
|
–
–
|
+123
-159
|
+2.5 (-113)
-2.5 (-113)
|
O 45.5 (-115)
U 45.5 (-110)
|
|
|
Sep 21, 2025 8:21PM EDT
Kansas City Chiefs
New York Giants
9/21/25 8:21PM
Chiefs
Giants
|
–
–
|
-315
+235
|
-6 (-112)
+6 (-114)
|
O 44.5 (-115)
U 44.5 (-110)
|
|
|
Sep 22, 2025 8:15PM EDT
Detroit Lions
Baltimore Ravens
9/22/25 8:15PM
Lions
Ravens
|
–
–
|
+190
-250
|
+5 (-115)
-5 (-110)
|
O 52.5 (-112)
U 52.5 (-113)
|
|
|
Sep 25, 2025 8:16PM EDT
Seattle Seahawks
Arizona Cardinals
9/25/25 8:16PM
Seahawks
Cardinals
|
–
–
|
+108
-137
|
+2.5 (-113)
-2.5 (-113)
|
O 43.5 (-113)
U 43.5 (-112)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Jacksonville Jaguars vs. San Francisco 49ers on September 28, 2025 at .
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
   LEAN |    %WIN |    UNITS | RESULT |
|---|---|---|---|---|
| LAC@LV | LAC -3 | 54.9% | 4 | WIN |
| TB@HOU | BAKER MAYFIELD OVER 1.5 PASS TDS | 54.4% | 4 | WIN |
| CHI@DET | DET -6.5 | 54.3% | 4 | WIN |
| DEN@IND | DEN -118 | 60.1% | 10 | LOSS |
| PHI@KC | PHI -115 | 56.7% | 6 | WIN |
| SF@NO | SF -3 | 58.8% | 8 | WIN |
| SEA@PIT | OVER 40 | 54.9% | 4 | WIN |
| CAR@ARI | BRYCE YOUNG INTERCEPTIONS UNDER 0.5 | 56.4% | 6 | LOSS |
| DEN@IND | JOSH DOWNS RECEPTIONS OVER 3.5 | 54.7% | 4 | WIN |
| ATL@MIN | BIJAN ROBINSON RUSH + REC YDS OVER 94.5 | 53.4% | 3 | WIN |
| WAS@GB | WAS +3.5 | 56.5% | 6 | LOSS |
| WAS@GB | JORDAN LOVE OVER 5.5 RUSH YDS | 54.7% | 4 | WIN |
| MIN@CHI | CALEB WILLIAMS OVER 219.5 PASS YDS | 53.4% | 3 | LOSS |
| TEN@DEN | DEN -8.5 | 55.3% | 5 | LOSS |
| SF@SEA | SF -115 | 54.6% | 4 | WIN |
| SF@SEA | KENNETH WALKER III UNDER 79.5 RUSH+REC YDS | 54.6% | 4 | WIN |
| CAR@JAC | TANK BIGSBY OVER 10.5 RUSH ATT | 56.1% | 6 | LOSS |
| KC@LAC | JUSTIN HERBERT UNDER 0.5 INT | 54.1% | 3 | WIN |
| DAL@PHI | GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS | 54.1% | 4 | LOSS |
| KC@PHI | JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS | 53.90% | 5 | WIN |
| KC@PHI | DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS | 54.40% | 6 | WIN |
| KC@PHI | PATRICK MAHOMES UNDER 68.3% PASS COMP | 55.00% | 8 | WIN |
| KC@PHI | JALEN HURTS LONGEST RUSH OVER 12.5 YDS | 55.60% | 8 | WIN |
| BUF@KC | DALTON KINCAID OVER 29.5 RECV YDS | 55.10% | 8 | LOSS |
| WAS@PHI | DEVONTA SMITH OVER 3.5 RECEPTIONS | 55.80% | 8 | WIN |
| BUF@KC | JAMES COOK ANYTIME TD | 53.00% | 5 | WIN |
| LAR@PHI | SAQUON BARKLEY UNDER 128 RUSH + REC YDS | 53.20% | 5 | LOSS |
| BAL@BUF | LAMAR JACKSON OVER 54.5 RUSH YDS | 54.50% | 6 | LOSS |
| HOU@KC | C.J. STROUD RUSH YDS UNDER 14.5 | 53.10% | 5 | LOSS |
| WAS@DET | JAMESON WILLIAMS RUSH YDS OVER 1.5 | 53.30% | 5 | WIN |
| WAS@DET | JARED GOFF PASS COMP % UNDER 72.3 | 54.30% | 6 | WIN |
| MIN@LAR | COOPER KUPP ANYTIME TOUCHDOWN | 52.60% | 3 | LOSS |
| MIN@LAR | MATTHEW STAFFORD OVER 21.5 PASS COMP | 54.10% | 6 | LOSS |
| WAS@TB | BRIAN ROBINSON JR OVER 1.5 REC TARGETS | 53.50% | 5 | WIN |
| WAS@TB | BAKER MAYFIELD UNDER 33.5 PASS ATT | 54.90% | 6 | WIN |
| GB@PHI | JALEN HURTS OVER 67.1 PASS COMP PERCENTAGE | 54.60% | 6 | LOSS |
| LAC@HOU | J.K. DOBBINS ANYTIME TD | 52.80% | 3 | LOSS |
| LAC@HOU | LAC -2.5 | 53.40% | 3 | LOSS |
| LAC@HOU | JUSTIN HERBERT OVER 19.5 RUSH YDS | 53.40% | 5 | LOSS |
| PIT@BAL | JUSTICE HILL OVER 2.5 RECEPTIONS | 55.30% | 8 | WIN |
| MIN@DET | DET -3 | 53.90% | 3 | WIN |
| KC@DEN | DEN -11.5 | 53.80% | 3 | WIN |
| MIN@DET | T.J. HOCKENSON RECV YDS OVER 46.5 | 55.00% | 6 | LOSS |
| SEA@LAR | ZACH CHARBONNET RECV YDS OVER 18.5 | 53.90% | 8 | WIN |
| TB@NO | BAKER MAYFIELD PASS ATT OVER 31.5 | 53.80% | 8 | WIN |
| CIN@PIT | CIN -130 | 56.20% | 3 | WIN |
| CIN@PIT | RUSSELL WILSON PASS ATT OVER 31.5 | 54.60% | 6 | LOSS |
| CLE@BAL | ELIJAH MOORE RECV TARGETS OVER 5.5 | 54.30% | 6 | LOSS |
| CIN@PIT | PAT FREIERMUTH ANYTIME TD (UNITS ADJ FOR +400 ODDS) | 52.50% | 9 | WIN |
| DET@SF | DET -3.5 | 54.10% | 4 | WIN |
| DET@SF | JAHMYR GIBBS LONGEST RUSH OVER 16.5 YDS | 53.60% | 5 | WIN |