Colts vs Rams Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 28)

Updated: 2025-09-21T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Indianapolis Colts ride a perfect 3–0 start into SoFi Stadium on September 28, 2025, where they face the Los Angeles Rams seeking to hand the Rams their first loss of the season. The Rams open as 3.5-point home underdogs in a matchup expecting offense, with the total floating around 49.5.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 28, 2025

Start Time: 4:05 PM EST​

Venue: SoFi Stadium​

Rams Record: (2-1)

Colts Record: (3-0)

OPENING ODDS

IND Moneyline: +155

LAR Moneyline: -186

IND Spread: +3.5

LAR Spread: -3.5

Over/Under: 49.5

IND
Betting Trends

  • The Colts enter 2025 with a 3–0 record and are 3–0 ATS to this point, demonstrating their ability to cover even as underdogs or favorites.

LAR
Betting Trends

  • Los Angeles is also 2–1 ATS this season, showing a respectable cover rate at home in early games.

MATCHUP TRENDS

  • Public betting heavily leans toward Indianapolis this week, with over 80% of ATS bets on the Colts in early markets. Also, the Rams are home underdogs despite their stadium advantage, underscoring how the betting market views this as a tilt toward Indy.

IND vs. LAR
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: D. Adams over 60.5 Receiving Yards.

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Indianapolis vs Los Angeles Prediction & Odds:
Free NFL Betting Insights for 9/28/25

The September 28, 2025 matchup between the Indianapolis Colts and Los Angeles Rams at SoFi Stadium is shaping up to be one of the most intriguing Week 4 contests, as both teams enter with winning records and legitimate questions about whether their early-season momentum can be sustained against stronger competition. The Colts have emerged as one of the NFL’s surprise stories, starting 3–0 behind the steady play of quarterback Daniel Jones, the resurgence of Jonathan Taylor in the backfield, and a defense that has shown opportunistic flashes at the right moments, but their offensive balance could be tested if wide receiver Alec Pierce remains out due to concussion protocol, which would limit their ability to stretch the field vertically and force them into shorter, more methodical drives. The Rams, meanwhile, have proven they can adapt and compete, with Matthew Stafford’s veteran poise giving them stability under center and Puka Nacua continuing to develop into a reliable target, while their defense has been strong enough to keep games close even when the offense has hit lulls.

For Los Angeles, the formula will revolve around slowing Taylor and forcing Jones to beat them under pressure, while offensively they’ll look to exploit Indy’s secondary with intermediate routes and timely shots downfield, hoping to leverage Stafford’s arm strength and timing. Indianapolis, on the other hand, will need its offensive line to dominate, control time of possession through Taylor’s carries, and use Jones’ legs and quick throws to neutralize the Rams’ pass rush, while defensively they’ll focus on compressing the pocket against Stafford and forcing him into mistakes, as his efficiency often dips when pressured heavily. Special teams could loom large, particularly in a high-total game projected around 49.5, where every possession and field position battle could swing momentum in what oddsmakers see as a potential shootout. The Colts are currently riding a 3–0 ATS start to the year, while the Rams sit at 2–1 ATS, but public betting has heavily tilted toward Indianapolis, creating an interesting market dynamic where expectations for the Colts may already be overinflated, especially given Pierce’s uncertain status. Ultimately, this matchup comes down to which team asserts itself in the trenches and adapts best when their primary options are limited—if the Colts can continue their balanced approach without Pierce, they’ll have every chance to extend their perfect start, but if the Rams can capitalize on home-field advantage and Stafford finds his rhythm with Nacua and company, Los Angeles could deliver Indy its first reality check of the season.

Indianapolis Colts NFL Preview

The Indianapolis Colts arrive at SoFi Stadium on September 28, 2025 with the swagger of an unbeaten 3–0 team and a growing belief that their formula for success can travel, but they also understand that this road test against the Rams could be their stiffest challenge to date. Daniel Jones has provided stability at quarterback, executing Shane Steichen’s offense with efficiency and avoiding costly mistakes, while Jonathan Taylor has looked every bit like the star running back who can carry the offense when needed, pounding out tough yards between the tackles and creating explosive gains in space. However, the possible absence of Alec Pierce due to concussion protocol means the Colts may have to adjust their passing game, relying more heavily on tight ends and shorter routes from Michael Pittman Jr. and Josh Downs to move the chains and control tempo. The offensive line will play a pivotal role here, as they must give Jones time to process against an aggressive Rams front that thrives on disrupting rhythm, and their ability to create running lanes for Taylor will dictate whether Indy can dictate pace.

Defensively, the Colts need to maintain gap discipline and pressure Matthew Stafford without overcommitting, as Stafford has shown he can punish defenses that leave windows open. Keeping Puka Nacua and the Rams’ receivers in check will be vital, and the secondary must stay disciplined on intermediate routes where Los Angeles often thrives. Special teams execution is also critical in a game where possessions will be precious, as hidden yardage and clean kicking could swing momentum. From a betting perspective, the Colts’ perfect 3–0 ATS record this season shows they’ve consistently outperformed expectations, but with public money heavily favoring them, they must prove they can handle that spotlight and avoid a trap on the road. The key for Indianapolis will be staying true to their identity—using Taylor to establish balance, leaning on Jones’ poise and decision-making, and playing opportunistic defense. If they do that while minimizing penalties and turnovers, they not only have a strong chance to stay undefeated but also to make another statement win that solidifies their place among the NFL’s early contenders.

The Indianapolis Colts ride a perfect 3–0 start into SoFi Stadium on September 28, 2025, where they face the Los Angeles Rams seeking to hand the Rams their first loss of the season. The Rams open as 3.5-point home underdogs in a matchup expecting offense, with the total floating around 49.5. Indianapolis vs Los Angeles AI Prediction: Free NFL Betting Insights for Sep 28. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Los Angeles Rams NFL Preview

The Los Angeles Rams enter their September 28, 2025 home matchup with the Indianapolis Colts knowing they have both the talent and the environment to hand the undefeated visitors their first loss of the season, and they’ll need to lean on those advantages if they want to protect SoFi Stadium. At 2–1 and already showing they can battle in tough games, the Rams will turn again to Matthew Stafford, whose veteran arm strength and poise remain the backbone of their offensive identity, while Puka Nacua has developed into one of the league’s most reliable young receivers, giving Stafford a go-to target who can win in contested catches and move the sticks. Los Angeles will look to balance their attack by establishing the run, both to control tempo and to keep Indianapolis’ defensive front from pinning its ears back, and mixing in screens or misdirection could help slow down the Colts’ pass rush. Defensively, the Rams’ front seven must be disciplined against Jonathan Taylor, whose explosive ability to flip field position can quickly tilt momentum; stuffing the run on early downs and forcing Daniel Jones into obvious passing situations will be key to taking Indy out of rhythm, especially if Alec Pierce is sidelined and the Colts lack a true vertical threat.

The Rams’ secondary will need to play physical at the line of scrimmage, crowding receivers and daring Jones to beat them under pressure, while also keeping eyes on his legs in case he extends plays outside the pocket. Special teams is another area where Los Angeles must be sharp, as a high-total game projected around 49.5 points means every possession and hidden yardage battle could impact the outcome. From a betting perspective, the Rams have been solid at 2–1 ATS and will embrace the role of home underdog, particularly with public money heavily backing Indianapolis, which gives them a chance to sneak value in this spot. Ultimately, Los Angeles’ path to victory hinges on Stafford’s ability to connect with Nacua and exploit gaps in coverage, the defense’s capacity to limit Taylor’s impact and generate pressure on Jones, and the crowd’s ability to rattle an undefeated opponent on the road. If the Rams can execute on those fronts, they have every chance to not only cover but deliver a statement win that keeps them firmly in the NFC playoff race.

Indianapolis vs. Los Angeles Prop Picks (AI)

AI algorithm Remi is pouring through loads of data on each line. In fact, anytime the Colts and Rams play there’s always several intriguing angles to key in on. Not to mention games played at SoFi Stadium in Sep can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: D. Adams over 60.5 Receiving Yards.

Indianapolis vs. Los Angeles Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every facet between the Colts and Rams and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.

Remi has been most watching on the trending factor knucklehead sportsbettors regularly put on coaching factors between a Colts team going up against a possibly improved Rams team. In reality, the true game analytics might reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Indianapolis vs Los Angeles picks, computer picks Colts vs Rams, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Colts Betting Trends

The Colts enter 2025 with a 3–0 record and are 3–0 ATS to this point, demonstrating their ability to cover even as underdogs or favorites.

Rams Betting Trends

Los Angeles is also 2–1 ATS this season, showing a respectable cover rate at home in early games.

Colts vs. Rams Matchup Trends

Public betting heavily leans toward Indianapolis this week, with over 80% of ATS bets on the Colts in early markets. Also, the Rams are home underdogs despite their stadium advantage, underscoring how the betting market views this as a tilt toward Indy.

Indianapolis vs. Los Angeles Game Info

Indianapolis vs Los Angeles starts on September 28, 2025 at 4:05 PM EST.

Spread: Los Angeles -3.5
Moneyline: Indianapolis +155, Los Angeles -186
Over/Under: 49.5

Indianapolis: (3-0)  |  Los Angeles: (2-1)

Remi's searched hard and found the best prop for this matchup: D. Adams over 60.5 Receiving Yards.. Prices move—always shop for the best number.

Public betting heavily leans toward Indianapolis this week, with over 80% of ATS bets on the Colts in early markets. Also, the Rams are home underdogs despite their stadium advantage, underscoring how the betting market views this as a tilt toward Indy.

IND trend: The Colts enter 2025 with a 3–0 record and are 3–0 ATS to this point, demonstrating their ability to cover even as underdogs or favorites.

LAR trend: Los Angeles is also 2–1 ATS this season, showing a respectable cover rate at home in early games.

See our latest NFL picks and odds pages for 2025 to compare prices before you bet.

Indianapolis vs. Los Angeles Odds

AI algorithm Remi is pouring through loads of data points on each team. In fact, anytime the Indianapolis vs Los Angeles trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable patterns.

Indianapolis vs Los Angeles Opening Odds

IND Moneyline: +155
LAR Moneyline: -186
IND Spread: +3.5
LAR Spread: -3.5
Over/Under: 49.5

Indianapolis vs Los Angeles Live Odds

Games PTS ML SPR O/U
Oct 30, 2025 8:15PM EDT
Baltimore Ravens
Miami Dolphins
10/30/25 8:15PM
Ravens
Dolphins
-420
+330
-7.5 (-115)
+7.5 (-105)
O 51.5 (-105)
U 51.5 (-115)
Nov 2, 2025 1:00PM EST
Chicago Bears
Cincinnati Bengals
11/2/25 1PM
Bears
Bengals
-142
+120
-2.5 (-110)
+2.5 (-110)
O 50.5 (-120)
U 50.5 (-102)
Nov 2, 2025 1:00PM EST
Indianapolis Colts
Pittsburgh Steelers
11/2/25 1PM
Colts
Steelers
-158
+134
-3 (-115)
+3 (-105)
O 50.5 (-104)
U 50.5 (-118)
Nov 2, 2025 1:00PM EST
Carolina Panthers
Green Bay Packers
11/2/25 1PM
Panthers
Packers
+700
-1100
+13.5 (-108)
-13.5 (-112)
O 44.5 (-105)
U 44.5 (-115)
Nov 2, 2025 1:00PM EST
Atlanta Falcons
New England Patriots
11/2/25 1PM
Falcons
Patriots
+190
-230
+5.5 (-115)
-5.5 (-105)
O 44.5 (-110)
U 44.5 (-110)
Nov 2, 2025 1:00PM EST
Denver Broncos
Houston Texans
11/2/25 1PM
Broncos
Texans
+102
-120
+1.5 (-108)
-1.5 (-112)
O 39.5 (-110)
U 39.5 (-110)
Nov 2, 2025 1:00PM EST
San Francisco 49ers
New York Giants
11/2/25 1PM
49ers
Giants
-146
+126
-2.5 (-115)
+2.5 (-105)
O 48.5 (-115)
U 48.5 (-105)
Nov 2, 2025 1:00PM EST
Los Angeles Chargers
Tennessee Titans
11/2/25 1PM
Chargers
Titans
-480
+370
-9.5 (-110)
+9.5 (-110)
O 43.5 (-105)
U 43.5 (-115)
Nov 2, 2025 1:00PM EST
Minnesota Vikings
Detroit Lions
11/2/25 1PM
Vikings
Lions
+370
-480
+8.5 (-108)
-8.5 (-112)
O 48.5 (-110)
U 48.5 (-110)
Nov 2, 2025 4:05PM EST
New Orleans Saints
Los Angeles Rams
11/2/25 4:05PM
Saints
Rams
+730
-1150
+14.5 (-115)
-14.5 (-105)
O 43.5 (-110)
U 43.5 (-110)
Nov 2, 2025 4:05PM EST
Jacksonville Jaguars
Las Vegas Raiders
11/2/25 4:05PM
Jaguars
Raiders
-158
+134
-3 (-105)
+3 (-115)
O 44.5 (-115)
U 44.5 (-105)
Nov 2, 2025 4:25PM EST
Kansas City Chiefs
Buffalo Bills
11/2/25 4:25PM
Chiefs
Bills
-134
+114
-1.5 (-114)
+1.5 (-106)
O 52.5 (-105)
U 52.5 (-115)
Nov 2, 2025 8:20PM EST
Seattle Seahawks
Washington Commanders
11/2/25 8:20PM
Seahawks
Commanders
-166
+140
-3 (-110)
+3 (-110)
O 47.5 (-112)
U 47.5 (-108)
Nov 3, 2025 8:15PM EST
Arizona Cardinals
Dallas Cowboys
11/3/25 8:15PM
Cardinals
Cowboys
+128
-152
+2.5 (-104)
-2.5 (-118)
O 53.5 (-110)
U 53.5 (-110)
Nov 6, 2025 8:15PM EST
Las Vegas Raiders
Denver Broncos
11/6/25 8:15PM
Raiders
Broncos
+370
-480
+9.5 (-115)
-9.5 (-105)
O 42.5 (-120)
U 42.5 (-102)
Nov 9, 2025 9:30AM EST
Atlanta Falcons
Indianapolis Colts
11/9/25 9:30AM
Falcons
Colts
+290
-360
+7 (-105)
-7 (-115)
O 48.5 (-108)
U 48.5 (-112)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Indianapolis Colts vs. Los Angeles Rams on September 28, 2025 at SoFi Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TB@NO TB -3.5 52.3% 1 WIN
GB@PIT GB -2.5 52.3% 1 WIN
SF@HOU SF +2.5 56.0% 6 LOSS
NYG@PHI NYG +7.5 53.9% 3 LOSS
BUF@CAR CAR +7.5 54.2% 3 LOSS
DAL@DEN DAL +3.5 55.0% 4 LOSS
MIA@ATL MIA +7 54.3% 4 WIN
CLE@NE CLE +7 56.8% 6 LOSS
TB@NO BAKER MAYFIELD OVER 15.5 RUSH YDS 56.6% 6 LOSS
MIN@LAC JUSTIN HERBERT PASS ATT UNDER 35.5 55.5% 5 WIN
TB@DET TB +6.5 54.4% 4 LOSS
TB@DET RACHAAD WHITE UNDER 14.5 RUSH ATT 54.4% 4 WIN
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS
HOU@BAL HOU -125 58.5% 7 WIN
DET@CIN DET -10 55.6% 5 WIN
DAL@NYJ NYJ +1.5 53.7% 3 LOSS
TB@SEA TB +3.5 54.9% 4 WIN
TEN@ARI ARI -7 (BUY 0.5) 54.9% 4 LOSS
DEN@PHI DEN +4.5 57.5% 7 WIN
MIA@CAR TETAIROA MCMILLAN OVER 58.5 RECV YDS 54.5% 4 WIN
LV@IND ASHTON JEANTY UNDER 67.5 RUSH YDS 54.4% 4 WIN
SF@LAR DEMARCUS ROBINSON OVER 29.5 RECV YDS 55.7% 5 WIN
NYJ@MIA NYJ +3 53.8 3 LOSS
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS