Colts vs. Rams
Prediction, Odds & Props
Sep 28 | NFL AI Picks

Updated: 2025-09-21T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Indianapolis Colts ride a perfect 3–0 start into SoFi Stadium on September 28, 2025, where they face the Los Angeles Rams seeking to hand the Rams their first loss of the season. The Rams open as 3.5-point home underdogs in a matchup expecting offense, with the total floating around 49.5.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 28, 2025

Start Time: 4:05 PM EST​

Venue: SoFi Stadium​

Rams Record: (2-1)

Colts Record: (3-0)

OPENING ODDS

IND Moneyline: +155

LAR Moneyline: -186

IND Spread: +3.5

LAR Spread: -3.5

Over/Under: 49.5

IND
Betting Trends

  • The Colts enter 2025 with a 3–0 record and are 3–0 ATS to this point, demonstrating their ability to cover even as underdogs or favorites.

LAR
Betting Trends

  • Los Angeles is also 2–1 ATS this season, showing a respectable cover rate at home in early games.

MATCHUP TRENDS

  • Public betting heavily leans toward Indianapolis this week, with over 80% of ATS bets on the Colts in early markets. Also, the Rams are home underdogs despite their stadium advantage, underscoring how the betting market views this as a tilt toward Indy.

IND vs. LAR
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: D. Adams over 60.5 Receiving Yards.

LIVE NFL ODDS

NFL ODDS COMPARISON

WANT MORE AI PICKS?

VAULT
VS. SPREAD
310-231
VAULT
NET UNITS
(INCL VIG)
+366.9
VAULT
NET PROFIT
(INCL VIG)
$100/UNIT
$36,686
EXECUTIVE
VS. SPREAD
1572-1340
EXECUTIVE
NET UNITS
(INCL VIG)
+391.8
EXECUTIVE
NET PROFIT
(INCL VIG)
$100/UNIT
$39,185

AI SPORTS PICK PRODUCTS

Create a Free Account

‘Create an Account’ to Get Remi’s Picks Today.

Remi Finds New Picks

Remi calculates the probability a team will cover the line.

Remi Works 24/7

Remi uses this probability to assign units to each pick.

Get Remi's AI Picks

Get Remi’s Top AI Sports Picks sent direct to your inbox.

Indianapolis vs Los Angeles Prediction & Odds:
Free NFL Betting Insights for 9/28/25

The September 28, 2025 matchup between the Indianapolis Colts and Los Angeles Rams at SoFi Stadium is shaping up to be one of the most intriguing Week 4 contests, as both teams enter with winning records and legitimate questions about whether their early-season momentum can be sustained against stronger competition. The Colts have emerged as one of the NFL’s surprise stories, starting 3–0 behind the steady play of quarterback Daniel Jones, the resurgence of Jonathan Taylor in the backfield, and a defense that has shown opportunistic flashes at the right moments, but their offensive balance could be tested if wide receiver Alec Pierce remains out due to concussion protocol, which would limit their ability to stretch the field vertically and force them into shorter, more methodical drives. The Rams, meanwhile, have proven they can adapt and compete, with Matthew Stafford’s veteran poise giving them stability under center and Puka Nacua continuing to develop into a reliable target, while their defense has been strong enough to keep games close even when the offense has hit lulls.

For Los Angeles, the formula will revolve around slowing Taylor and forcing Jones to beat them under pressure, while offensively they’ll look to exploit Indy’s secondary with intermediate routes and timely shots downfield, hoping to leverage Stafford’s arm strength and timing. Indianapolis, on the other hand, will need its offensive line to dominate, control time of possession through Taylor’s carries, and use Jones’ legs and quick throws to neutralize the Rams’ pass rush, while defensively they’ll focus on compressing the pocket against Stafford and forcing him into mistakes, as his efficiency often dips when pressured heavily. Special teams could loom large, particularly in a high-total game projected around 49.5, where every possession and field position battle could swing momentum in what oddsmakers see as a potential shootout. The Colts are currently riding a 3–0 ATS start to the year, while the Rams sit at 2–1 ATS, but public betting has heavily tilted toward Indianapolis, creating an interesting market dynamic where expectations for the Colts may already be overinflated, especially given Pierce’s uncertain status. Ultimately, this matchup comes down to which team asserts itself in the trenches and adapts best when their primary options are limited—if the Colts can continue their balanced approach without Pierce, they’ll have every chance to extend their perfect start, but if the Rams can capitalize on home-field advantage and Stafford finds his rhythm with Nacua and company, Los Angeles could deliver Indy its first reality check of the season.

Indianapolis Colts NFL Preview

The Indianapolis Colts arrive at SoFi Stadium on September 28, 2025 with the swagger of an unbeaten 3–0 team and a growing belief that their formula for success can travel, but they also understand that this road test against the Rams could be their stiffest challenge to date. Daniel Jones has provided stability at quarterback, executing Shane Steichen’s offense with efficiency and avoiding costly mistakes, while Jonathan Taylor has looked every bit like the star running back who can carry the offense when needed, pounding out tough yards between the tackles and creating explosive gains in space. However, the possible absence of Alec Pierce due to concussion protocol means the Colts may have to adjust their passing game, relying more heavily on tight ends and shorter routes from Michael Pittman Jr. and Josh Downs to move the chains and control tempo. The offensive line will play a pivotal role here, as they must give Jones time to process against an aggressive Rams front that thrives on disrupting rhythm, and their ability to create running lanes for Taylor will dictate whether Indy can dictate pace.

Defensively, the Colts need to maintain gap discipline and pressure Matthew Stafford without overcommitting, as Stafford has shown he can punish defenses that leave windows open. Keeping Puka Nacua and the Rams’ receivers in check will be vital, and the secondary must stay disciplined on intermediate routes where Los Angeles often thrives. Special teams execution is also critical in a game where possessions will be precious, as hidden yardage and clean kicking could swing momentum. From a betting perspective, the Colts’ perfect 3–0 ATS record this season shows they’ve consistently outperformed expectations, but with public money heavily favoring them, they must prove they can handle that spotlight and avoid a trap on the road. The key for Indianapolis will be staying true to their identity—using Taylor to establish balance, leaning on Jones’ poise and decision-making, and playing opportunistic defense. If they do that while minimizing penalties and turnovers, they not only have a strong chance to stay undefeated but also to make another statement win that solidifies their place among the NFL’s early contenders.

The Indianapolis Colts ride a perfect 3–0 start into SoFi Stadium on September 28, 2025, where they face the Los Angeles Rams seeking to hand the Rams their first loss of the season. The Rams open as 3.5-point home underdogs in a matchup expecting offense, with the total floating around 49.5. Indianapolis vs Los Angeles AI Prediction: Free NFL Betting Insights for Sep 28. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Los Angeles Rams NFL Preview

The Los Angeles Rams enter their September 28, 2025 home matchup with the Indianapolis Colts knowing they have both the talent and the environment to hand the undefeated visitors their first loss of the season, and they’ll need to lean on those advantages if they want to protect SoFi Stadium. At 2–1 and already showing they can battle in tough games, the Rams will turn again to Matthew Stafford, whose veteran arm strength and poise remain the backbone of their offensive identity, while Puka Nacua has developed into one of the league’s most reliable young receivers, giving Stafford a go-to target who can win in contested catches and move the sticks. Los Angeles will look to balance their attack by establishing the run, both to control tempo and to keep Indianapolis’ defensive front from pinning its ears back, and mixing in screens or misdirection could help slow down the Colts’ pass rush. Defensively, the Rams’ front seven must be disciplined against Jonathan Taylor, whose explosive ability to flip field position can quickly tilt momentum; stuffing the run on early downs and forcing Daniel Jones into obvious passing situations will be key to taking Indy out of rhythm, especially if Alec Pierce is sidelined and the Colts lack a true vertical threat.

The Rams’ secondary will need to play physical at the line of scrimmage, crowding receivers and daring Jones to beat them under pressure, while also keeping eyes on his legs in case he extends plays outside the pocket. Special teams is another area where Los Angeles must be sharp, as a high-total game projected around 49.5 points means every possession and hidden yardage battle could impact the outcome. From a betting perspective, the Rams have been solid at 2–1 ATS and will embrace the role of home underdog, particularly with public money heavily backing Indianapolis, which gives them a chance to sneak value in this spot. Ultimately, Los Angeles’ path to victory hinges on Stafford’s ability to connect with Nacua and exploit gaps in coverage, the defense’s capacity to limit Taylor’s impact and generate pressure on Jones, and the crowd’s ability to rattle an undefeated opponent on the road. If the Rams can execute on those fronts, they have every chance to not only cover but deliver a statement win that keeps them firmly in the NFC playoff race.

Indianapolis vs. Los Angeles Prop Picks (AI)

AI algorithm Remi is pouring through tons of stats on each line. In fact, anytime the Colts and Rams play there’s always several intriguing angles to key in on. Not to mention games played at SoFi Stadium in Sep almost always follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: D. Adams over 60.5 Receiving Yards.

Indianapolis vs. Los Angeles Prediction (AI)

Remi Robot Icon

Remi, our AI sports genius, has been pouring over mountains of data from every simulation between the Colts and Rams and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.

Interestingly enough, the data has been most focused on the unproportionally assigned emphasis knucklehead sportsbettors tend to put on player performance factors between a Colts team going up against a possibly tired Rams team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Indianapolis vs Los Angeles picks, computer picks Colts vs Rams, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NFL 10/5 HOU@BAL UNLOCK THIS PICK 9 INTEL Locked INTEL
NFL 10/5 DEN@PHI UNLOCK THIS PICK 7 VAULT v3 Locked VAULT v3
NFL 10/5 HOU@BAL UNLOCK THIS PICK 7 VAULT v2 Locked VAULT v2
NFL 10/5 DET@CIN UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
NFL 10/5 LV@IND UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/5 MIA@CAR UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/5 TEN@ARI UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/5 TB@SEA UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/5 NE@BUF UNLOCK THIS PICK 3 INTEL Locked INTEL
NFL 10/5 DAL@NYJ UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
NFL 10/5 NE@BUF UNLOCK THIS PICK 10 INTEL Locked INTEL
NFL 10/5 NE@BUF GET FREE PICK NOW 1
NFL 10/5 WAS@LAC UNLOCK THIS PICK 0 INTEL Locked INTEL
NFL 10/5 WAS@LAC UNLOCK THIS PICK 1 INTEL Locked INTEL
NFL 10/5 LV@IND UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Colts Betting Trends

The Colts enter 2025 with a 3–0 record and are 3–0 ATS to this point, demonstrating their ability to cover even as underdogs or favorites.

Rams Betting Trends

Los Angeles is also 2–1 ATS this season, showing a respectable cover rate at home in early games.

Colts vs. Rams Matchup Trends

Public betting heavily leans toward Indianapolis this week, with over 80% of ATS bets on the Colts in early markets. Also, the Rams are home underdogs despite their stadium advantage, underscoring how the betting market views this as a tilt toward Indy.

Indianapolis vs. Los Angeles Game Info

Indianapolis vs Los Angeles starts on September 28, 2025 at 4:05 PM EST.

Spread: Los Angeles -3.5
Moneyline: Indianapolis +155, Los Angeles -186
Over/Under: 49.5

Indianapolis: (3-0)  |  Los Angeles: (2-1)

Remi's searched hard and found the best prop for this matchup: D. Adams over 60.5 Receiving Yards.. Prices move—always shop for the best number.

Public betting heavily leans toward Indianapolis this week, with over 80% of ATS bets on the Colts in early markets. Also, the Rams are home underdogs despite their stadium advantage, underscoring how the betting market views this as a tilt toward Indy.

IND trend: The Colts enter 2025 with a 3–0 record and are 3–0 ATS to this point, demonstrating their ability to cover even as underdogs or favorites.

LAR trend: Los Angeles is also 2–1 ATS this season, showing a respectable cover rate at home in early games.

See our latest NFL picks and odds pages for 2025 to compare prices before you bet.

Indianapolis vs. Los Angeles Odds

Remi is pouring through loads of data points on each team. In fact, anytime the Indianapolis vs Los Angeles trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps almost always follow normal, predictable patterns.

Indianapolis vs Los Angeles Opening Odds

IND Moneyline: +155
LAR Moneyline: -186
IND Spread: +3.5
LAR Spread: -3.5
Over/Under: 49.5

Indianapolis vs Los Angeles Live Odds

Games PTS ML SPR O/U
Oct 6, 2025 8:16PM EDT
Kansas City Chiefs
Jacksonville Jaguars
10/6/25 8:16PM
Chiefs
Jaguars
-190
+148
-3.5 (-108)
+3.5 (-118)
O 45.5 (-115)
U 45.5 (-110)
Oct 9, 2025 8:15PM EDT
Philadelphia Eagles
New York Giants
10/9/25 8:15PM
Eagles
Giants
-400
+290
-7.5 (-113)
+7.5 (-113)
O 41.5 (-112)
U 41.5 (-114)
Oct 12, 2025 8:31AM EDT
Denver Broncos
New York Jets
10/12/25 8:31AM
Broncos
Jets
-345
+260
-7 (-113)
+7 (-113)
O 43.5 (-112)
U 43.5 (-113)
Oct 12, 2025 1:01PM EDT
Cleveland Browns
Pittsburgh Steelers
10/12/25 1:01PM
Browns
Steelers
+195
-250
+5 (-114)
-5 (-112)
O 38.5 (-110)
U 38.5 (-115)
Oct 12, 2025 1:01PM EDT
Los Angeles Chargers
Miami Dolphins
10/12/25 1:01PM
Chargers
Dolphins
-250
+188
-5.5 (-114)
+5.5 (-112)
O 45 (-112)
U 45 (-114)
Oct 12, 2025 1:01PM EDT
Los Angeles Rams
Baltimore Ravens
10/12/25 1:01PM
Rams
Ravens
-385
+280
-7.5 (-114)
+7.5 (-112)
O 45.5 (-114)
U 45.5 (-112)
Oct 12, 2025 1:01PM EDT
Dallas Cowboys
Carolina Panthers
10/12/25 1:01PM
Cowboys
Panthers
-195
+145
-3.5 (-114)
+3.5 (-112)
O 48 (-114)
U 48 (-112)
Oct 12, 2025 1:01PM EDT
Arizona Cardinals
Indianapolis Colts
10/12/25 1:01PM
Cardinals
Colts
+188
-250
+5.5 (-114)
-5.5 (-112)
O 47 (-109)
U 47 (-117)
Oct 12, 2025 1:01PM EDT
Seattle Seahawks
Jacksonville Jaguars
10/12/25 1:01PM
Seahawks
Jaguars
-105
-122
+1 (-112)
-1 (-114)
O 44.5 (-110)
U 44.5 (-115)
Oct 12, 2025 4:06PM EDT
Tennessee Titans
Las Vegas Raiders
10/12/25 4:06PM
Titans
Raiders
+220
-286
+6 (-115)
-6 (-110)
O 41 (-117)
U 41 (-109)
Oct 12, 2025 4:25PM EDT
New England Patriots
New Orleans Saints
10/12/25 4:25PM
Patriots
Saints
-205
+160
-3.5 (-110)
+3.5 (-114)
O 46.5 (-113)
U 46.5 (-112)
Oct 12, 2025 4:26PM EDT
Cincinnati Bengals
Green Bay Packers
10/12/25 4:26PM
Bengals
Packers
+600
-1115
+14.5 (-115)
-14.5 (-110)
O 43.5 (-112)
U 43.5 (-114)
Oct 12, 2025 4:26PM EDT
San Francisco 49ers
Tampa Bay Buccaneers
10/12/25 4:26PM
49ers
Buccaneers
+125
-162
+3 (-112)
-3 (-114)
O 47.5 (-113)
U 47.5 (-113)
Oct 12, 2025 8:21PM EDT
Detroit Lions
Kansas City Chiefs
10/12/25 8:21PM
Lions
Chiefs
-104
-124
+1 (-110)
-1 (-115)
O 50 (-113)
U 50 (-113)
Oct 13, 2025 7:15PM EDT
Buffalo Bills
Atlanta Falcons
10/13/25 7:15PM
Bills
Falcons
-220
+163
-4.5 (-112)
+4.5 (-114)
O 49.5 (-113)
U 49.5 (-113)
Oct 13, 2025 8:16PM EDT
Chicago Bears
Washington Commanders
10/13/25 8:16PM
Bears
Commanders
+163
-215
+4.5 (-113)
-4.5 (-113)
O 50.5 (-112)
U 50.5 (-113)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Indianapolis Colts vs. Los Angeles Rams on September 28, 2025 at SoFi Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS
TEN@HOU TEN +7.5 57.9% 7 LOSS
LAC@NYG LAC -6 57.3% 7 LOSS
NO@BUF UNDER 48.5 55.1% 3 LOSS
GB@DAL JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS 55.5% 5 LOSS
CAR@NE DRAKE MAYE TO THROW AN INT 56.6% 6 LOSS
SEA@ARI SEA -125 57.7% 6 WIN
SEA@ARI KYLER MURRAY TO THROW AN INT 56.6% 6 WIN
DET@BAL JAHMYR GIBBS OVER 0.5 RUSH TDS 55.8% 5 WIN
DAL@CHI DAL -120 58.7% 6 LOSS
PIT@NE PIT -116 60.1% 6 WIN
ATL@CAR ATL -4.5 55.4% 5 LOSS
LV@WAS LV +3 54.3% 4 LOSS
GB@CLE GB -7 54.3% 4 LOSS
ARI@SF ARI +3 57.7% 6 WIN
KC@NYG PATRICK MAHOMES OVER 230.5 PASS YDS 54.7% 4 WIN
GB@CLE JOE FLACCO OVER 37.5 PASS ATT 56.6% 6 LOSS
MIA@BUF TYREEK HILL OVER 5.5 TOTAL RECEPTIONS 56.8% 6 LOSS
LAC@LV LAC -3 54.9% 4 WIN
TB@HOU BAKER MAYFIELD OVER 1.5 PASS TDS 54.4% 4 WIN
CHI@DET DET -6.5 54.3% 4 WIN
DEN@IND DEN -118 60.1% 10 LOSS
PHI@KC PHI -115 56.7% 6 WIN
SF@NO SF -3 58.8% 8 WIN
SEA@PIT OVER 40 54.9% 4 WIN
CAR@ARI BRYCE YOUNG INTERCEPTIONS UNDER 0.5 56.4% 6 LOSS
DEN@IND JOSH DOWNS RECEPTIONS OVER 3.5 54.7% 4 WIN
ATL@MIN BIJAN ROBINSON RUSH + REC YDS OVER 94.5 53.4% 3 WIN
WAS@GB WAS +3.5 56.5% 6 LOSS
WAS@GB JORDAN LOVE OVER 5.5 RUSH YDS 54.7% 4 WIN
MIN@CHI CALEB WILLIAMS OVER 219.5 PASS YDS 53.4% 3 LOSS
TEN@DEN DEN -8.5 55.3% 5 LOSS
SF@SEA SF -115 54.6% 4 WIN
SF@SEA KENNETH WALKER III UNDER 79.5 RUSH+REC YDS 54.6% 4 WIN
CAR@JAC TANK BIGSBY OVER 10.5 RUSH ATT 56.1% 6 LOSS
KC@LAC JUSTIN HERBERT UNDER 0.5 INT 54.1% 3 WIN
DAL@PHI GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS 54.1% 4 LOSS
KC@PHI JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS 53.90% 5 WIN
KC@PHI DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS 54.40% 6 WIN
KC@PHI PATRICK MAHOMES UNDER 68.3% PASS COMP 55.00% 8 WIN
KC@PHI JALEN HURTS LONGEST RUSH OVER 12.5 YDS 55.60% 8 WIN
BUF@KC DALTON KINCAID OVER 29.5 RECV YDS 55.10% 8 LOSS
WAS@PHI DEVONTA SMITH OVER 3.5 RECEPTIONS 55.80% 8 WIN
BUF@KC JAMES COOK ANYTIME TD 53.00% 5 WIN
LAR@PHI SAQUON BARKLEY UNDER 128 RUSH + REC YDS 53.20% 5 LOSS