Colts vs. Rams
Prediction, Odds & Props
Sep 28 | NFL AI Picks
Updated: 2025-09-21T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Indianapolis Colts ride a perfect 3–0 start into SoFi Stadium on September 28, 2025, where they face the Los Angeles Rams seeking to hand the Rams their first loss of the season. The Rams open as 3.5-point home underdogs in a matchup expecting offense, with the total floating around 49.5.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 28, 2025
Start Time: 4:05 PM EST
Venue: SoFi Stadium
Rams Record: (2-1)
Colts Record: (3-0)
OPENING ODDS
IND Moneyline: +155
LAR Moneyline: -186
IND Spread: +3.5
LAR Spread: -3.5
Over/Under: 49.5
IND
Betting Trends
- The Colts enter 2025 with a 3–0 record and are 3–0 ATS to this point, demonstrating their ability to cover even as underdogs or favorites.
LAR
Betting Trends
- Los Angeles is also 2–1 ATS this season, showing a respectable cover rate at home in early games.
MATCHUP TRENDS
- Public betting heavily leans toward Indianapolis this week, with over 80% of ATS bets on the Colts in early markets. Also, the Rams are home underdogs despite their stadium advantage, underscoring how the betting market views this as a tilt toward Indy.
IND vs. LAR
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: D. Adams over 60.5 Receiving Yards.
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Indianapolis vs Los Angeles Prediction & Odds:
Free NFL Betting Insights for 9/28/25
For Los Angeles, the formula will revolve around slowing Taylor and forcing Jones to beat them under pressure, while offensively they’ll look to exploit Indy’s secondary with intermediate routes and timely shots downfield, hoping to leverage Stafford’s arm strength and timing. Indianapolis, on the other hand, will need its offensive line to dominate, control time of possession through Taylor’s carries, and use Jones’ legs and quick throws to neutralize the Rams’ pass rush, while defensively they’ll focus on compressing the pocket against Stafford and forcing him into mistakes, as his efficiency often dips when pressured heavily. Special teams could loom large, particularly in a high-total game projected around 49.5, where every possession and field position battle could swing momentum in what oddsmakers see as a potential shootout. The Colts are currently riding a 3–0 ATS start to the year, while the Rams sit at 2–1 ATS, but public betting has heavily tilted toward Indianapolis, creating an interesting market dynamic where expectations for the Colts may already be overinflated, especially given Pierce’s uncertain status. Ultimately, this matchup comes down to which team asserts itself in the trenches and adapts best when their primary options are limited—if the Colts can continue their balanced approach without Pierce, they’ll have every chance to extend their perfect start, but if the Rams can capitalize on home-field advantage and Stafford finds his rhythm with Nacua and company, Los Angeles could deliver Indy its first reality check of the season.
twenty ATE. 🔥 pic.twitter.com/6rMMFgfZjV
— Indianapolis Colts (@Colts) September 24, 2025
Indianapolis Colts NFL Preview
The Indianapolis Colts arrive at SoFi Stadium on September 28, 2025 with the swagger of an unbeaten 3–0 team and a growing belief that their formula for success can travel, but they also understand that this road test against the Rams could be their stiffest challenge to date. Daniel Jones has provided stability at quarterback, executing Shane Steichen’s offense with efficiency and avoiding costly mistakes, while Jonathan Taylor has looked every bit like the star running back who can carry the offense when needed, pounding out tough yards between the tackles and creating explosive gains in space. However, the possible absence of Alec Pierce due to concussion protocol means the Colts may have to adjust their passing game, relying more heavily on tight ends and shorter routes from Michael Pittman Jr. and Josh Downs to move the chains and control tempo. The offensive line will play a pivotal role here, as they must give Jones time to process against an aggressive Rams front that thrives on disrupting rhythm, and their ability to create running lanes for Taylor will dictate whether Indy can dictate pace.
Defensively, the Colts need to maintain gap discipline and pressure Matthew Stafford without overcommitting, as Stafford has shown he can punish defenses that leave windows open. Keeping Puka Nacua and the Rams’ receivers in check will be vital, and the secondary must stay disciplined on intermediate routes where Los Angeles often thrives. Special teams execution is also critical in a game where possessions will be precious, as hidden yardage and clean kicking could swing momentum. From a betting perspective, the Colts’ perfect 3–0 ATS record this season shows they’ve consistently outperformed expectations, but with public money heavily favoring them, they must prove they can handle that spotlight and avoid a trap on the road. The key for Indianapolis will be staying true to their identity—using Taylor to establish balance, leaning on Jones’ poise and decision-making, and playing opportunistic defense. If they do that while minimizing penalties and turnovers, they not only have a strong chance to stay undefeated but also to make another statement win that solidifies their place among the NFL’s early contenders.

Credit: USA TODAY/IMAGN
Los Angeles Rams NFL Preview
The Los Angeles Rams enter their September 28, 2025 home matchup with the Indianapolis Colts knowing they have both the talent and the environment to hand the undefeated visitors their first loss of the season, and they’ll need to lean on those advantages if they want to protect SoFi Stadium. At 2–1 and already showing they can battle in tough games, the Rams will turn again to Matthew Stafford, whose veteran arm strength and poise remain the backbone of their offensive identity, while Puka Nacua has developed into one of the league’s most reliable young receivers, giving Stafford a go-to target who can win in contested catches and move the sticks. Los Angeles will look to balance their attack by establishing the run, both to control tempo and to keep Indianapolis’ defensive front from pinning its ears back, and mixing in screens or misdirection could help slow down the Colts’ pass rush. Defensively, the Rams’ front seven must be disciplined against Jonathan Taylor, whose explosive ability to flip field position can quickly tilt momentum; stuffing the run on early downs and forcing Daniel Jones into obvious passing situations will be key to taking Indy out of rhythm, especially if Alec Pierce is sidelined and the Colts lack a true vertical threat.
The Rams’ secondary will need to play physical at the line of scrimmage, crowding receivers and daring Jones to beat them under pressure, while also keeping eyes on his legs in case he extends plays outside the pocket. Special teams is another area where Los Angeles must be sharp, as a high-total game projected around 49.5 points means every possession and hidden yardage battle could impact the outcome. From a betting perspective, the Rams have been solid at 2–1 ATS and will embrace the role of home underdog, particularly with public money heavily backing Indianapolis, which gives them a chance to sneak value in this spot. Ultimately, Los Angeles’ path to victory hinges on Stafford’s ability to connect with Nacua and exploit gaps in coverage, the defense’s capacity to limit Taylor’s impact and generate pressure on Jones, and the crowd’s ability to rattle an undefeated opponent on the road. If the Rams can execute on those fronts, they have every chance to not only cover but deliver a statement win that keeps them firmly in the NFC playoff race.
Bounce back for Week 4. 🐏🏠 » https://t.co/w1A2id3jlx pic.twitter.com/u0XHgW9ZsP
— Los Angeles Rams (@RamsNFL) September 24, 2025
Indianapolis vs. Los Angeles Prop Picks (AI)
Indianapolis vs. Los Angeles Prediction (AI)

Remi, our AI sports genius, has been pouring over mountains of data from every simulation between the Colts and Rams and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.
Interestingly enough, the data has been most focused on the unproportionally assigned emphasis knucklehead sportsbettors tend to put on player performance factors between a Colts team going up against a possibly tired Rams team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Indianapolis vs Los Angeles picks, computer picks Colts vs Rams, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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NFL | 10/5 | HOU@BAL | UNLOCK THIS PICK | 9 |
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NFL | 10/5 | DEN@PHI | UNLOCK THIS PICK | 7 |
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NFL | 10/5 | HOU@BAL | UNLOCK THIS PICK | 7 |
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NFL | 10/5 | DET@CIN | UNLOCK THIS PICK | 5 |
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NFL | 10/5 | LV@IND | UNLOCK THIS PICK | 4 |
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NFL | 10/5 | MIA@CAR | UNLOCK THIS PICK | 4 |
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NFL | 10/5 | TEN@ARI | UNLOCK THIS PICK | 4 |
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NFL | 10/5 | TB@SEA | UNLOCK THIS PICK | 4 |
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NFL | 10/5 | NE@BUF | UNLOCK THIS PICK | 3 |
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NFL | 10/5 | DAL@NYJ | UNLOCK THIS PICK | 3 |
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NFL | 10/5 | NE@BUF | UNLOCK THIS PICK | 10 |
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NFL | 10/5 | NE@BUF | GET FREE PICK NOW | 1 | – | |
NFL | 10/5 | WAS@LAC | UNLOCK THIS PICK | 0 |
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NFL | 10/5 | WAS@LAC | UNLOCK THIS PICK | 1 |
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NFL | 10/5 | LV@IND | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Colts Betting Trends
The Colts enter 2025 with a 3–0 record and are 3–0 ATS to this point, demonstrating their ability to cover even as underdogs or favorites.
Rams Betting Trends
Los Angeles is also 2–1 ATS this season, showing a respectable cover rate at home in early games.
Colts vs. Rams Matchup Trends
Public betting heavily leans toward Indianapolis this week, with over 80% of ATS bets on the Colts in early markets. Also, the Rams are home underdogs despite their stadium advantage, underscoring how the betting market views this as a tilt toward Indy.
Indianapolis vs. Los Angeles Game Info
What time does Indianapolis vs Los Angeles start on September 28, 2025?
Indianapolis vs Los Angeles starts on September 28, 2025 at 4:05 PM EST.
Where is Indianapolis vs Los Angeles being played?
Venue: SoFi Stadium.
What are the opening odds for Indianapolis vs Los Angeles?
Spread: Los Angeles -3.5
Moneyline: Indianapolis +155, Los Angeles -186
Over/Under: 49.5
What are the records for Indianapolis vs Los Angeles?
Indianapolis: (3-0) | Los Angeles: (2-1)
What is the AI best bet for Indianapolis vs Los Angeles?
Remi's searched hard and found the best prop for this matchup: D. Adams over 60.5 Receiving Yards.. Prices move—always shop for the best number.
What are Indianapolis vs Los Angeles trending bets?
Public betting heavily leans toward Indianapolis this week, with over 80% of ATS bets on the Colts in early markets. Also, the Rams are home underdogs despite their stadium advantage, underscoring how the betting market views this as a tilt toward Indy.
What are Indianapolis trending bets?
IND trend: The Colts enter 2025 with a 3–0 record and are 3–0 ATS to this point, demonstrating their ability to cover even as underdogs or favorites.
What are Los Angeles trending bets?
LAR trend: Los Angeles is also 2–1 ATS this season, showing a respectable cover rate at home in early games.
Where can I find AI Picks for Indianapolis vs Los Angeles?
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Indianapolis vs. Los Angeles Odds
Remi is pouring through loads of data points on each team. In fact, anytime the Indianapolis vs Los Angeles trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps almost always follow normal, predictable patterns.
Indianapolis vs Los Angeles Opening Odds
IND Moneyline:
+155 LAR Moneyline: -186
IND Spread: +3.5
LAR Spread: -3.5
Over/Under: 49.5
Indianapolis vs Los Angeles Live Odds
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Kansas City Chiefs
Jacksonville Jaguars
10/6/25 8:16PM
Chiefs
Jaguars
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–
–
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-190
+148
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-3.5 (-108)
+3.5 (-118)
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O 45.5 (-115)
U 45.5 (-110)
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Philadelphia Eagles
New York Giants
10/9/25 8:15PM
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Giants
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–
–
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-400
+290
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-7.5 (-113)
+7.5 (-113)
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O 41.5 (-112)
U 41.5 (-114)
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Oct 12, 2025 8:31AM EDT
Denver Broncos
New York Jets
10/12/25 8:31AM
Broncos
Jets
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–
–
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-345
+260
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-7 (-113)
+7 (-113)
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O 43.5 (-112)
U 43.5 (-113)
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Oct 12, 2025 1:01PM EDT
Cleveland Browns
Pittsburgh Steelers
10/12/25 1:01PM
Browns
Steelers
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–
–
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+195
-250
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+5 (-114)
-5 (-112)
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O 38.5 (-110)
U 38.5 (-115)
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Oct 12, 2025 1:01PM EDT
Los Angeles Chargers
Miami Dolphins
10/12/25 1:01PM
Chargers
Dolphins
|
–
–
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-250
+188
|
-5.5 (-114)
+5.5 (-112)
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O 45 (-112)
U 45 (-114)
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Oct 12, 2025 1:01PM EDT
Los Angeles Rams
Baltimore Ravens
10/12/25 1:01PM
Rams
Ravens
|
–
–
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-385
+280
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-7.5 (-114)
+7.5 (-112)
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O 45.5 (-114)
U 45.5 (-112)
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Oct 12, 2025 1:01PM EDT
Dallas Cowboys
Carolina Panthers
10/12/25 1:01PM
Cowboys
Panthers
|
–
–
|
-195
+145
|
-3.5 (-114)
+3.5 (-112)
|
O 48 (-114)
U 48 (-112)
|
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Oct 12, 2025 1:01PM EDT
Arizona Cardinals
Indianapolis Colts
10/12/25 1:01PM
Cardinals
Colts
|
–
–
|
+188
-250
|
+5.5 (-114)
-5.5 (-112)
|
O 47 (-109)
U 47 (-117)
|
|
Oct 12, 2025 1:01PM EDT
Seattle Seahawks
Jacksonville Jaguars
10/12/25 1:01PM
Seahawks
Jaguars
|
–
–
|
-105
-122
|
+1 (-112)
-1 (-114)
|
O 44.5 (-110)
U 44.5 (-115)
|
|
Oct 12, 2025 4:06PM EDT
Tennessee Titans
Las Vegas Raiders
10/12/25 4:06PM
Titans
Raiders
|
–
–
|
+220
-286
|
+6 (-115)
-6 (-110)
|
O 41 (-117)
U 41 (-109)
|
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Oct 12, 2025 4:25PM EDT
New England Patriots
New Orleans Saints
10/12/25 4:25PM
Patriots
Saints
|
–
–
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-205
+160
|
-3.5 (-110)
+3.5 (-114)
|
O 46.5 (-113)
U 46.5 (-112)
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Oct 12, 2025 4:26PM EDT
Cincinnati Bengals
Green Bay Packers
10/12/25 4:26PM
Bengals
Packers
|
–
–
|
+600
-1115
|
+14.5 (-115)
-14.5 (-110)
|
O 43.5 (-112)
U 43.5 (-114)
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Oct 12, 2025 4:26PM EDT
San Francisco 49ers
Tampa Bay Buccaneers
10/12/25 4:26PM
49ers
Buccaneers
|
–
–
|
+125
-162
|
+3 (-112)
-3 (-114)
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O 47.5 (-113)
U 47.5 (-113)
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Oct 12, 2025 8:21PM EDT
Detroit Lions
Kansas City Chiefs
10/12/25 8:21PM
Lions
Chiefs
|
–
–
|
-104
-124
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+1 (-110)
-1 (-115)
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O 50 (-113)
U 50 (-113)
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Oct 13, 2025 7:15PM EDT
Buffalo Bills
Atlanta Falcons
10/13/25 7:15PM
Bills
Falcons
|
–
–
|
-220
+163
|
-4.5 (-112)
+4.5 (-114)
|
O 49.5 (-113)
U 49.5 (-113)
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Oct 13, 2025 8:16PM EDT
Chicago Bears
Washington Commanders
10/13/25 8:16PM
Bears
Commanders
|
–
–
|
+163
-215
|
+4.5 (-113)
-4.5 (-113)
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O 50.5 (-112)
U 50.5 (-113)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Indianapolis Colts vs. Los Angeles Rams on September 28, 2025 at SoFi Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
PIT@NE | PIT -116 | 60.1% | 6 | WIN |
ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
LV@WAS | LV +3 | 54.3% | 4 | LOSS |
GB@CLE | GB -7 | 54.3% | 4 | LOSS |
ARI@SF | ARI +3 | 57.7% | 6 | WIN |
KC@NYG | PATRICK MAHOMES OVER 230.5 PASS YDS | 54.7% | 4 | WIN |
GB@CLE | JOE FLACCO OVER 37.5 PASS ATT | 56.6% | 6 | LOSS |
MIA@BUF | TYREEK HILL OVER 5.5 TOTAL RECEPTIONS | 56.8% | 6 | LOSS |
LAC@LV | LAC -3 | 54.9% | 4 | WIN |
TB@HOU | BAKER MAYFIELD OVER 1.5 PASS TDS | 54.4% | 4 | WIN |
CHI@DET | DET -6.5 | 54.3% | 4 | WIN |
DEN@IND | DEN -118 | 60.1% | 10 | LOSS |
PHI@KC | PHI -115 | 56.7% | 6 | WIN |
SF@NO | SF -3 | 58.8% | 8 | WIN |
SEA@PIT | OVER 40 | 54.9% | 4 | WIN |
CAR@ARI | BRYCE YOUNG INTERCEPTIONS UNDER 0.5 | 56.4% | 6 | LOSS |
DEN@IND | JOSH DOWNS RECEPTIONS OVER 3.5 | 54.7% | 4 | WIN |
ATL@MIN | BIJAN ROBINSON RUSH + REC YDS OVER 94.5 | 53.4% | 3 | WIN |
WAS@GB | WAS +3.5 | 56.5% | 6 | LOSS |
WAS@GB | JORDAN LOVE OVER 5.5 RUSH YDS | 54.7% | 4 | WIN |
MIN@CHI | CALEB WILLIAMS OVER 219.5 PASS YDS | 53.4% | 3 | LOSS |
TEN@DEN | DEN -8.5 | 55.3% | 5 | LOSS |
SF@SEA | SF -115 | 54.6% | 4 | WIN |
SF@SEA | KENNETH WALKER III UNDER 79.5 RUSH+REC YDS | 54.6% | 4 | WIN |
CAR@JAC | TANK BIGSBY OVER 10.5 RUSH ATT | 56.1% | 6 | LOSS |
KC@LAC | JUSTIN HERBERT UNDER 0.5 INT | 54.1% | 3 | WIN |
DAL@PHI | GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS | 54.1% | 4 | LOSS |
KC@PHI | JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS | 53.90% | 5 | WIN |
KC@PHI | DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS | 54.40% | 6 | WIN |
KC@PHI | PATRICK MAHOMES UNDER 68.3% PASS COMP | 55.00% | 8 | WIN |
KC@PHI | JALEN HURTS LONGEST RUSH OVER 12.5 YDS | 55.60% | 8 | WIN |
BUF@KC | DALTON KINCAID OVER 29.5 RECV YDS | 55.10% | 8 | LOSS |
WAS@PHI | DEVONTA SMITH OVER 3.5 RECEPTIONS | 55.80% | 8 | WIN |
BUF@KC | JAMES COOK ANYTIME TD | 53.00% | 5 | WIN |
LAR@PHI | SAQUON BARKLEY UNDER 128 RUSH + REC YDS | 53.20% | 5 | LOSS |