Colts vs. Rams
FREE NFL AI Predictions
September 28, 2025
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 28, 2025
Start Time: 4:05 PM EST​
Venue: ​
Rams Record:
Colts Record:
OPENING ODDS
IND Moneyline:
LAR Moneyline:
IND Spread: 0
LAR Spread:
Over/Under:
IND
Betting Trends
LAR
Betting Trends
MATCHUP TRENDS
IND vs. LAR
Best Prop Bet
LIVE NFL ODDS
NFL ODDS COMPARISON
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VS. SPREAD
300-211
NET UNITS
(INCL VIG)
+437.5
NET PROFIT
(INCL VIG)
$100/UNIT
$43,753
VS. SPREAD
1527-1319
NET UNITS
(INCL VIG)
+326.8
NET PROFIT
(INCL VIG)
$100/UNIT
$32,679
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Indianapolis vs Los Angeles AI Prediction:
Free NFL Betting Insights for 9/28/25
Colts AI Preview

Credit: USA TODAY/IMAGN
Rams AI Preview
Colts vs. Rams FREE Prop Pick
Remi is pouring through tons of datapoints on each line. In fact, anytime the Colts and Rams play there’s always several intriguing angles to key in on. Not to mention games played at in Sep can often follow normal, predictable betting trends.
Indianapolis vs. Los Angeles NFL AI Pick

Remi, our AI sports wizard, has been pouring over millions of data from every past game between the Colts and Rams and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.
Remi has been most keyed in on the linear correlation of factor knucklehead sportsbettors often put on coaching factors between a Colts team going up against a possibly deflated Rams team. It appears the true game analytics appear to reflect a strong lean against one Vegas line in particular.
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