The September 28, 2025 matchup between the Indianapolis Colts and Los Angeles Rams at SoFi Stadium is shaping up to be one of the most intriguing Week 4 contests, as both teams enter with winning records and legitimate questions about whether their early-season momentum can be sustained against stronger competition. The Colts have emerged as one of the NFL’s surprise stories, starting 3–0 behind the steady play of quarterback Daniel Jones, the resurgence of Jonathan Taylor in the backfield, and a defense that has shown opportunistic flashes at the right moments, but their offensive balance could be tested if wide receiver Alec Pierce remains out due to concussion protocol, which would limit their ability to stretch the field vertically and force them into shorter, more methodical drives. The Rams, meanwhile, have proven they can adapt and compete, with Matthew Stafford’s veteran poise giving them stability under center and Puka Nacua continuing to develop into a reliable target, while their defense has been strong enough to keep games close even when the offense has hit lulls.

For Los Angeles, the formula will revolve around slowing Taylor and forcing Jones to beat them under pressure, while offensively they’ll look to exploit Indy’s secondary with intermediate routes and timely shots downfield, hoping to leverage Stafford’s arm strength and timing. Indianapolis, on the other hand, will need its offensive line to dominate, control time of possession through Taylor’s carries, and use Jones’ legs and quick throws to neutralize the Rams’ pass rush, while defensively they’ll focus on compressing the pocket against Stafford and forcing him into mistakes, as his efficiency often dips when pressured heavily. Special teams could loom large, particularly in a high-total game projected around 49.5, where every possession and field position battle could swing momentum in what oddsmakers see as a potential shootout. The Colts are currently riding a 3–0 ATS start to the year, while the Rams sit at 2–1 ATS, but public betting has heavily tilted toward Indianapolis, creating an interesting market dynamic where expectations for the Colts may already be overinflated, especially given Pierce’s uncertain status. Ultimately, this matchup comes down to which team asserts itself in the trenches and adapts best when their primary options are limited—if the Colts can continue their balanced approach without Pierce, they’ll have every chance to extend their perfect start, but if the Rams can capitalize on home-field advantage and Stafford finds his rhythm with Nacua and company, Los Angeles could deliver Indy its first reality check of the season.