Browns vs Lions Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 28)
Updated: 2025-09-21T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Browns travel to Detroit on September 28, 2025, to take on the Lions in a matchup where Cleveland’s tough defense meets Detroit’s explosive offense under the lights at Ford Field. Detroit enters as a heavy favorite—opening as an 8.5-point favorite according to sportsbook lines—while the over/under is estimated near 45.5 points. 
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 28, 2025
Start Time: 1:00 PM EST
Venue: Ford Field
Lions Record: (2-1)
Browns Record: (1-2)
OPENING ODDS
CLE Moneyline: +379
DET Moneyline: -503
CLE Spread: +9.5
DET Spread: -9.5
Over/Under: 44.5
CLE
Betting Trends
- Cleveland is 1–3 ATS so far this season, and their road betting profile is weak, often struggling to stay close as underdogs.
DET
Betting Trends
- Detroit has fared better against the spread at home historically and is expected to cover as an 8.5-point favorite in this game.
MATCHUP TRENDS
- The betting public is overwhelmingly backing Detroit to cover, with the Lions’ offense having scored 90 points over their past two games—adding swagger to their cover chances.
CLE vs. DET
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: Q. Judkins over 57.5 Rushing Yards.
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Cleveland vs Detroit Prediction & Odds:
Free NFL Betting Insights for 9/28/25
The Browns’ best path to competitiveness is to turn the game into a grind, leaning on their defensive front to create negative plays, slowing Detroit’s ground game, and hoping their secondary can limit explosive passes; any turnovers they can force would be crucial to stealing possessions. Offensively, they must simplify—using quick passes, screens, and misdirection to move the chains methodically—because asking their quarterback to stand in the pocket against Detroit’s pass rush is a recipe for disaster. Special teams could also loom large, as Cleveland will need every hidden yard they can scrape together to shorten fields and keep the pressure off their sputtering offense. From a betting perspective, Detroit’s surge and Cleveland’s 1–3 ATS record make the Lions the popular pick, and with the total hovering around 45.5, bettors will weigh whether the Browns can contribute enough points to push the over. Ultimately, this game looks like another showcase opportunity for Detroit to flex its offensive depth and home-field edge, while Cleveland faces an uphill battle to avoid being overwhelmed unless their defense delivers one of its best games of the year and their offense finally finds rhythm in a hostile environment.
can't make this Szmyt up pic.twitter.com/O3chkACWMZ
— Cleveland Browns (@Browns) September 24, 2025
Cleveland Browns NFL Preview
The Cleveland Browns head into Ford Field on September 28, 2025 as clear underdogs, searching for answers after a rough start to their season that has seen their offense sputter and their defense stretched thin. Sitting at 1–3 ATS so far, the Browns have not traveled well, and facing a Lions team that has scored 90 points in its last two games only heightens the challenge. Offensively, Cleveland has been plagued by inconsistency up front, with their offensive line struggling to keep the quarterback upright and their rushing attack failing to establish the kind of control that once defined their identity. To compete in Detroit, they must shorten the game and lean into efficiency—quick throws, screens, and misdirection to backs and tight ends that move the chains while minimizing negative plays. Stretching the field vertically has been an issue, but taking calculated shots will be necessary to prevent the Lions’ defense from keying on short routes.
Defensively, the Browns will lean on their front four to disrupt Jared Goff’s timing, plug rushing lanes, and generate the kind of pressure that forces turnovers, because stealing possessions is their best path to staying competitive. The secondary must play disciplined football, especially against Detroit’s play-action-heavy schemes that thrive on baiting linebackers and safeties into mistakes. Special teams will also be vital; flipping the field and preventing long returns could give Cleveland’s defense some breathing room and perhaps create opportunities to keep the score manageable. From a betting perspective, Cleveland’s poor ATS form and the wide 8.5-point line make them a risky play, though bettors looking for a contrarian angle might hope their defense keeps the game closer than projected. Ultimately, the Browns’ road to victory is narrow and depends on near-perfect execution: win the turnover battle, grind out long drives, avoid penalties, and hope their defense can slow down a Detroit offense that has looked unstoppable in recent weeks.
Credit: USA TODAY/IMAGN
Detroit Lions NFL Preview
The Detroit Lions enter their September 28, 2025 matchup against the Cleveland Browns as confident heavy favorites, backed by both a roaring home crowd at Ford Field and the momentum of an offense that has exploded for 90 points over their last two games. Jared Goff has settled into complete command of Ben Johnson’s system, spreading the ball efficiently to his receivers while benefiting from one of the league’s most reliable offensive lines that creates both protection and running lanes. Detroit’s backfield has been balanced and punishing, setting the tone on the ground and allowing play-action concepts to open up big plays downfield, which will test a Browns secondary that has already shown vulnerability when stretched vertically. The Lions’ offensive versatility makes them difficult to game plan against, as defenses cannot overcommit to stopping the run without exposing themselves to Goff’s timing-based passing attack.
On the other side of the ball, Detroit’s defense has embraced physicality, using its front seven to apply steady pressure and force opponents into long-yardage situations where mistakes become inevitable. Against a Cleveland offense that has struggled with consistency, this unit will look to dominate the line of scrimmage, limit rushing production, and pressure the quarterback into hurried decisions. Home field has also been a key factor in Detroit’s recent success, as the energy of Ford Field has fueled their fast starts and helped them close out games with conviction. Special teams have quietly been reliable as well, giving the Lions an edge in hidden yardage that complements their offensive efficiency. From a betting standpoint, Detroit’s strong ATS record at home contrasts sharply with Cleveland’s struggles on the road, making the Lions’ side of the line an attractive play even at -8.5. Ultimately, this is a game where Detroit controls its own destiny; if they avoid turnovers and maintain the balance that has made them one of the NFL’s most dangerous offenses, they are well positioned not just to win, but to dominate in front of their home fans and further solidify themselves as a legitimate NFC contender.
Applying pressure pic.twitter.com/OH2rjY2Myr
— Detroit Lions (@Lions) September 24, 2025
Cleveland vs. Detroit Prop Picks (AI)
Cleveland vs. Detroit Prediction (AI)
Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every simulation between the Browns and Lions and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most keyed in on the growing factor knucklehead sportsbettors tend to put on coaching factors between a Browns team going up against a possibly tired Lions team. It appears the true game analytics appear to reflect a strong lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Cleveland vs Detroit picks, computer picks Browns vs Lions, best bets, model edges, confidence ratings.
| DATE | GAME | LEAN | %WIN | UNITS | LEVEL | |
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| NFL | 10/23 | MIN@LAC | UNLOCK THIS PICK | 5 |
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| NFL | 10/23 | MIN@LAC | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Browns Betting Trends
Cleveland is 1–3 ATS so far this season, and their road betting profile is weak, often struggling to stay close as underdogs.
Lions Betting Trends
Detroit has fared better against the spread at home historically and is expected to cover as an 8.5-point favorite in this game.
Browns vs. Lions Matchup Trends
The betting public is overwhelmingly backing Detroit to cover, with the Lions’ offense having scored 90 points over their past two games—adding swagger to their cover chances.
Cleveland vs. Detroit Game Info
What time does Cleveland vs Detroit start on September 28, 2025?
Cleveland vs Detroit starts on September 28, 2025 at 1:00 PM EST.
Where is Cleveland vs Detroit being played?
Venue: Ford Field.
What are the opening odds for Cleveland vs Detroit?
Spread: Detroit -9.5
Moneyline: Cleveland +379, Detroit -503
Over/Under: 44.5
What are the records for Cleveland vs Detroit?
Cleveland: (1-2) | Detroit: (2-1)
What is the AI best bet for Cleveland vs Detroit?
Remi's searched hard and found the best prop for this matchup: Q. Judkins over 57.5 Rushing Yards.. Prices move—always shop for the best number.
What are Cleveland vs Detroit trending bets?
The betting public is overwhelmingly backing Detroit to cover, with the Lions’ offense having scored 90 points over their past two games—adding swagger to their cover chances.
What are Cleveland trending bets?
CLE trend: Cleveland is 1–3 ATS so far this season, and their road betting profile is weak, often struggling to stay close as underdogs.
What are Detroit trending bets?
DET trend: Detroit has fared better against the spread at home historically and is expected to cover as an 8.5-point favorite in this game.
Where can I find AI Picks for Cleveland vs Detroit?
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Cleveland vs. Detroit Odds
AI algorithm Remi is pouring through loads of stats on each player. In fact, anytime the Cleveland vs Detroit trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance can often follow normal, predictable betting trends.
Cleveland vs Detroit Opening Odds
CLE Moneyline:
+379 DET Moneyline: -503
CLE Spread: +9.5
DET Spread: -9.5
Over/Under: 44.5
Cleveland vs Detroit Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
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In Progress
Minnesota Vikings
Los Angeles Chargers
In Progress
Vikings
Chargers
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10
24
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+3000
-50000
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+17.5 (-130)
-17.5 (-102)
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O 47.5 (-136)
U 47.5 (+102)
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Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
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–
–
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+290
-360
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+7 (-114)
-7 (-106)
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O 40.5 (-105)
U 40.5 (-115)
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Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
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–
–
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-390
+310
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-7.5 (-102)
+7.5 (-120)
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O 46.5 (-110)
U 46.5 (-110)
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Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
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–
–
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+240
-295
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+6.5 (-115)
-6.5 (-105)
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O 44.5 (-110)
U 44.5 (-110)
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Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
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–
–
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+245
-300
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+6.5 (-110)
-6.5 (-110)
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O 49.5 (-110)
U 49.5 (-110)
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Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
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–
–
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+300
-375
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+7.5 (-120)
-7.5 (-102)
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O 43.5 (-114)
U 43.5 (-106)
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Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
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–
–
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+118
-138
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+2.5 (-108)
-2.5 (-112)
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O 41.5 (-106)
U 41.5 (-114)
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Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
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–
–
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+330
-420
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+7.5 (-112)
-7.5 (-108)
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O 44.5 (-114)
U 44.5 (-106)
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Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
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–
–
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-215
+180
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-4.5 (-104)
+4.5 (-118)
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O 46.5 (-108)
U 46.5 (-112)
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Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
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–
–
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+144
-172
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+3.5 (-115)
-3.5 (-105)
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O 50.5 (-118)
U 50.5 (-104)
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Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
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–
–
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+750
-1200
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+14.5 (-110)
-14.5 (-110)
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O 46.5 (-120)
U 46.5 (-102)
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Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
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–
–
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-154
+130
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-3 (-102)
+3 (-120)
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O 45.5 (-105)
U 45.5 (-115)
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Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
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–
–
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+560
-800
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+11.5 (-102)
-11.5 (-120)
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O 47.5 (-115)
U 47.5 (-105)
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Oct 30, 2025 8:15PM EDT
Baltimore Ravens
Miami Dolphins
10/30/25 8:15PM
Ravens
Dolphins
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–
–
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-420
+330
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-8.5 (-105)
+8.5 (-115)
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O 48.5 (-105)
U 48.5 (-115)
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Nov 2, 2025 1:00PM EST
Chicago Bears
Cincinnati Bengals
11/2/25 1PM
Bears
Bengals
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–
–
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-124
+106
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-1.5 (-110)
+1.5 (-110)
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O 47.5 (-110)
U 47.5 (-110)
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Nov 2, 2025 1:00PM EST
Indianapolis Colts
Pittsburgh Steelers
11/2/25 1PM
Colts
Steelers
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–
–
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-142
+120
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-2.5 (-114)
+2.5 (-106)
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O 47.5 (-115)
U 47.5 (-105)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Cleveland Browns vs. Detroit Lions on September 28, 2025 at Ford Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| LEAN | %WIN | UNITS | RESULT | |
|---|---|---|---|---|
| TB@DET | RACHAAD WHITE UNDER 14.5 RUSH ATT | 54.4% | 4 | WIN |
| NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
| CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
| PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
| GB@ARI | ARI +7 | 54.8% | 5 | WIN |
| NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
| WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
| GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
| PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
| BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
| CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
| TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
| DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
| SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
| LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
| ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
| TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
| LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
| SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
| CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
| DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
| KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
| KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
| HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
| DET@CIN | DET -10 | 55.6% | 5 | WIN |
| DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
| TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
| TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
| DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
| MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
| LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
| SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
| NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
| CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
| NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
| CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
| NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
| CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
| WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
| BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
| TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
| LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
| NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
| GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
| CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |