Panthers vs. Patriots
Prediction, Odds & Props
Sep 28 | NFL AI Picks
Updated: 2025-09-21T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 28, 2025
Start Time: 1:00 PM EST​
Venue: ​
Patriots Record:
Panthers Record:
OPENING ODDS
CAR Moneyline:
NE Moneyline:
CAR Spread: 0
NE Spread:
Over/Under:
CAR
Betting Trends
NE
Betting Trends
MATCHUP TRENDS
CAR vs. NE
Best Prop Bet
LIVE NFL ODDS
NFL ODDS COMPARISON
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Carolina vs New England Prediction & Odds:
Free NFL Betting Insights for 9/28/25
Carolina Panthers NFL Preview
Credit: USA TODAY/IMAGN
New England Patriots NFL Preview
Carolina vs. New England Prop Picks (AI)
Carolina vs. New England Prediction (AI)
Remi, our AI sports algorithm, has been pouring over mountains of data from every facet between the Panthers and Patriots and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.
Remi has been most watching on the unproportionally assigned factor human bettors tend to put on coaching factors between a Panthers team going up against a possibly tired Patriots team. We’ve found the true game analytics might reflect a moderate lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Carolina vs New England picks, computer picks Panthers vs Patriots, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
|---|---|---|---|---|---|---|
| NFL | 9/18 | MIA@BUF | UNLOCK THIS PICK | 6 |
VAULT v3
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| NFL | 9/18 | MIA@BUF | UNLOCK THIS PICK | 1 |
INTEL
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| NFL | 9/18 | MIA@BUF | GET FREE PICK NOW | 1 | – | |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number.
Panthers Betting Trends
Patriots Betting Trends
Panthers vs. Patriots Matchup Trends
Carolina vs. New England Game Info
What time does Carolina vs New England start on September 28, 2025?
Carolina vs New England starts on September 28, 2025 at 1:00 PM EST.
What are the opening odds for Carolina vs New England?
Spread: New England
Moneyline: Carolina , New England
Over/Under:
What are the records for Carolina vs New England?
Carolina: Â |Â New England:
What is the AI best bet for Carolina vs New England?
. Prices move—always shop for the best number.
What are Carolina trending bets?
CAR trend:
What are New England trending bets?
NE trend:
Where can I find AI Picks for Carolina vs New England?
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Carolina vs. New England Odds
AI algorithm Remi is pouring through loads of data points on each team. In fact, anytime the Carolina vs New England trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude can often follow normal, predictable betting trends.
Carolina vs New England Opening Odds
CAR Moneyline:
NE Moneyline:
CAR Spread: 0
NE Spread:
Over/Under:
Carolina vs New England Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Sep 21, 2025 1:00PM EDT
New York Jets
Tampa Bay Buccaneers
9/21/25 1PM
Jets
Buccaneers
|
–
–
|
+255
-345
|
+6.5 (-110)
-6.5 (-115)
|
O 43.5 (-113)
U 43.5 (-113)
|
|
|
Sep 21, 2025 1:00PM EDT
Las Vegas Raiders
Washington Commanders
9/21/25 1PM
Raiders
Commanders
|
–
–
|
+143
-186
|
+3.5 (-115)
-3.5 (-110)
|
O 44 (-115)
U 44 (-110)
|
|
|
Sep 21, 2025 1:00PM EDT
Atlanta Falcons
Carolina Panthers
9/21/25 1PM
Falcons
Panthers
|
–
–
|
-250
+195
|
-5.5 (-114)
+5.5 (-112)
|
O 43.5 (-112)
U 43.5 (-113)
|
|
|
Sep 21, 2025 1:00PM EDT
Green Bay Packers
Cleveland Browns
9/21/25 1PM
Packers
Browns
|
–
–
|
-480
+330
|
-8 (-110)
+8 (-115)
|
O 41.5 (-113)
U 41.5 (-113)
|
|
|
Sep 21, 2025 1:00PM EDT
Houston Texans
Jacksonville Jaguars
9/21/25 1PM
Texans
Jaguars
|
–
–
|
+100
-125
|
+1.5 (-113)
-1.5 (-113)
|
O 44 (-112)
U 44 (-114)
|
|
|
Sep 21, 2025 1:00PM EDT
Pittsburgh Steelers
New England Patriots
9/21/25 1PM
Steelers
Patriots
|
–
–
|
-125
+100
|
-1.5 (-113)
+1.5 (-113)
|
O 44.5 (-112)
U 44.5 (-114)
|
|
|
Sep 21, 2025 1:00PM EDT
Cincinnati Bengals
Minnesota Vikings
9/21/25 1PM
Bengals
Vikings
|
–
–
|
+120
-152
|
+3 (-117)
-3 (-108)
|
O 42 (-114)
U 42 (-112)
|
|
|
Sep 21, 2025 1:01PM EDT
Los Angeles Rams
Philadelphia Eagles
9/21/25 1:01PM
Rams
Eagles
|
–
–
|
+155
-195
|
+3.5 (-120)
-3.5 (-107)
|
O 44.5 (-113)
U 44.5 (-113)
|
|
|
Sep 21, 2025 1:01PM EDT
Indianapolis Colts
Tennessee Titans
9/21/25 1:01PM
Colts
Titans
|
–
–
|
-215
+165
|
-4 (-113)
+4 (-113)
|
O 43.5 (-114)
U 43.5 (-112)
|
|
|
Sep 21, 2025 4:05PM EDT
Denver Broncos
Los Angeles Chargers
9/21/25 4:05PM
Broncos
Chargers
|
–
–
|
+120
-150
|
+2.5 (-109)
-2.5 (-115)
|
O 45.5 (-112)
U 45.5 (-114)
|
|
|
Sep 21, 2025 4:05PM EDT
New Orleans Saints
Seattle Seahawks
9/21/25 4:05PM
Saints
Seahawks
|
–
–
|
+295
-420
|
+7.5 (-117)
-7.5 (-109)
|
O 41.5 (-114)
U 41.5 (-112)
|
|
|
Sep 21, 2025 4:25PM EDT
Dallas Cowboys
Chicago Bears
9/21/25 4:25PM
Cowboys
Bears
|
–
–
|
-114
-110
|
pk
pk
|
O 50.5 (-112)
U 50.5 (-114)
|
|
|
Sep 21, 2025 4:26PM EDT
Arizona Cardinals
San Francisco 49ers
9/21/25 4:26PM
Cardinals
49ers
|
–
–
|
+123
-159
|
+2.5 (-113)
-2.5 (-113)
|
O 45.5 (-115)
U 45.5 (-110)
|
|
|
Sep 21, 2025 8:21PM EDT
Kansas City Chiefs
New York Giants
9/21/25 8:21PM
Chiefs
Giants
|
–
–
|
-315
+235
|
-6 (-112)
+6 (-114)
|
O 44.5 (-115)
U 44.5 (-110)
|
|
|
Sep 22, 2025 8:15PM EDT
Detroit Lions
Baltimore Ravens
9/22/25 8:15PM
Lions
Ravens
|
–
–
|
+190
-250
|
+5 (-115)
-5 (-110)
|
O 52.5 (-112)
U 52.5 (-113)
|
|
|
Sep 25, 2025 8:16PM EDT
Seattle Seahawks
Arizona Cardinals
9/25/25 8:16PM
Seahawks
Cardinals
|
–
–
|
+108
-137
|
+2.5 (-113)
-2.5 (-113)
|
O 43.5 (-113)
U 43.5 (-112)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Carolina Panthers vs. New England Patriots on September 28, 2025 at .
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
   LEAN |    %WIN |    UNITS | RESULT |
|---|---|---|---|---|
| LAC@LV | LAC -3 | 54.9% | 4 | WIN |
| TB@HOU | BAKER MAYFIELD OVER 1.5 PASS TDS | 54.4% | 4 | WIN |
| CHI@DET | DET -6.5 | 54.3% | 4 | WIN |
| DEN@IND | DEN -118 | 60.1% | 10 | LOSS |
| PHI@KC | PHI -115 | 56.7% | 6 | WIN |
| SF@NO | SF -3 | 58.8% | 8 | WIN |
| SEA@PIT | OVER 40 | 54.9% | 4 | WIN |
| CAR@ARI | BRYCE YOUNG INTERCEPTIONS UNDER 0.5 | 56.4% | 6 | LOSS |
| DEN@IND | JOSH DOWNS RECEPTIONS OVER 3.5 | 54.7% | 4 | WIN |
| ATL@MIN | BIJAN ROBINSON RUSH + REC YDS OVER 94.5 | 53.4% | 3 | WIN |
| WAS@GB | WAS +3.5 | 56.5% | 6 | LOSS |
| WAS@GB | JORDAN LOVE OVER 5.5 RUSH YDS | 54.7% | 4 | WIN |
| MIN@CHI | CALEB WILLIAMS OVER 219.5 PASS YDS | 53.4% | 3 | LOSS |
| TEN@DEN | DEN -8.5 | 55.3% | 5 | LOSS |
| SF@SEA | SF -115 | 54.6% | 4 | WIN |
| SF@SEA | KENNETH WALKER III UNDER 79.5 RUSH+REC YDS | 54.6% | 4 | WIN |
| CAR@JAC | TANK BIGSBY OVER 10.5 RUSH ATT | 56.1% | 6 | LOSS |
| KC@LAC | JUSTIN HERBERT UNDER 0.5 INT | 54.1% | 3 | WIN |
| DAL@PHI | GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS | 54.1% | 4 | LOSS |
| KC@PHI | JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS | 53.90% | 5 | WIN |
| KC@PHI | DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS | 54.40% | 6 | WIN |
| KC@PHI | PATRICK MAHOMES UNDER 68.3% PASS COMP | 55.00% | 8 | WIN |
| KC@PHI | JALEN HURTS LONGEST RUSH OVER 12.5 YDS | 55.60% | 8 | WIN |
| BUF@KC | DALTON KINCAID OVER 29.5 RECV YDS | 55.10% | 8 | LOSS |
| WAS@PHI | DEVONTA SMITH OVER 3.5 RECEPTIONS | 55.80% | 8 | WIN |
| BUF@KC | JAMES COOK ANYTIME TD | 53.00% | 5 | WIN |
| LAR@PHI | SAQUON BARKLEY UNDER 128 RUSH + REC YDS | 53.20% | 5 | LOSS |
| BAL@BUF | LAMAR JACKSON OVER 54.5 RUSH YDS | 54.50% | 6 | LOSS |
| HOU@KC | C.J. STROUD RUSH YDS UNDER 14.5 | 53.10% | 5 | LOSS |
| WAS@DET | JAMESON WILLIAMS RUSH YDS OVER 1.5 | 53.30% | 5 | WIN |
| WAS@DET | JARED GOFF PASS COMP % UNDER 72.3 | 54.30% | 6 | WIN |
| MIN@LAR | COOPER KUPP ANYTIME TOUCHDOWN | 52.60% | 3 | LOSS |
| MIN@LAR | MATTHEW STAFFORD OVER 21.5 PASS COMP | 54.10% | 6 | LOSS |
| WAS@TB | BRIAN ROBINSON JR OVER 1.5 REC TARGETS | 53.50% | 5 | WIN |
| WAS@TB | BAKER MAYFIELD UNDER 33.5 PASS ATT | 54.90% | 6 | WIN |
| GB@PHI | JALEN HURTS OVER 67.1 PASS COMP PERCENTAGE | 54.60% | 6 | LOSS |
| LAC@HOU | J.K. DOBBINS ANYTIME TD | 52.80% | 3 | LOSS |
| LAC@HOU | LAC -2.5 | 53.40% | 3 | LOSS |
| LAC@HOU | JUSTIN HERBERT OVER 19.5 RUSH YDS | 53.40% | 5 | LOSS |
| PIT@BAL | JUSTICE HILL OVER 2.5 RECEPTIONS | 55.30% | 8 | WIN |
| MIN@DET | DET -3 | 53.90% | 3 | WIN |
| KC@DEN | DEN -11.5 | 53.80% | 3 | WIN |
| MIN@DET | T.J. HOCKENSON RECV YDS OVER 46.5 | 55.00% | 6 | LOSS |
| SEA@LAR | ZACH CHARBONNET RECV YDS OVER 18.5 | 53.90% | 8 | WIN |
| TB@NO | BAKER MAYFIELD PASS ATT OVER 31.5 | 53.80% | 8 | WIN |
| CIN@PIT | CIN -130 | 56.20% | 3 | WIN |
| CIN@PIT | RUSSELL WILSON PASS ATT OVER 31.5 | 54.60% | 6 | LOSS |
| CLE@BAL | ELIJAH MOORE RECV TARGETS OVER 5.5 | 54.30% | 6 | LOSS |
| CIN@PIT | PAT FREIERMUTH ANYTIME TD (UNITS ADJ FOR +400 ODDS) | 52.50% | 9 | WIN |
| DET@SF | DET -3.5 | 54.10% | 4 | WIN |
| DET@SF | JAHMYR GIBBS LONGEST RUSH OVER 16.5 YDS | 53.60% | 5 | WIN |