Panthers vs Patriots Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 28)

Updated: 2025-09-21T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Carolina Panthers travel to Foxborough to take on the New England Patriots on September 28, 2025, with both teams sitting at 1–2 and seeking momentum. New England enters as a modest favorite at –4.5 in the spread, with the over/under line set around 44.5.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 28, 2025

Start Time: 1:00 PM EST​

Venue: Gillette Stadium​

Patriots Record: (1-2)

Panthers Record: (1-2)

OPENING ODDS

CAR Moneyline: +196

NE Moneyline: -240

CAR Spread: +5.5

NE Spread: -5.5

Over/Under: 43.5

CAR
Betting Trends

  • Carolina has a 1–2 ATS record this season, and their road ATS performance has been shaky, particularly in competitive matchups.

NE
Betting Trends

  • New England is 1–2 ATS so far in 2025, with a middling cover rate that hasn’t inspired full confidence in their home spreads.

MATCHUP TRENDS

  • The injury to Carolina’s starting tight end Ja’Tavion Sanders—who will miss this game—removes a key target from Bryce Young’s offense and may tilt value toward New England’s side. Also, Patriots cornerback Christian Gonzalez is ramping up for a return from a hamstring injury, which could strengthen a pass defense that ranks near the bottom early this season.

CAR vs. NE
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: H. Henry over 38.5 Receiving Yards.

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Carolina vs New England Prediction & Odds:
Free NFL Betting Insights for 9/28/25

The September 28, 2025 matchup between the Carolina Panthers and the New England Patriots at Gillette Stadium is the kind of early-season game that may not draw national headlines but carries plenty of intrigue for two franchises trying to define themselves after uneven starts. Both teams sit at 1–2, and the oddsmakers have installed New England as a modest 4.5-point favorite at home, a reflection of their slightly more consistent form and the challenge of Carolina adjusting without starting tight end Ja’Tavion Sanders, who will miss the game with an injury. The Patriots’ defense has been under scrutiny, ranking near the bottom of the league in pass yards allowed, but the expected return of cornerback Christian Gonzalez provides a timely boost against Bryce Young and a Panthers offense still searching for rhythm. For Carolina, Young’s development remains the centerpiece of their long-term vision, but without Sanders, the short-to-intermediate passing game will need to be retooled, putting more pressure on their wide receivers and backs to create separation and give the young quarterback safe options. Establishing the run will be vital to balance out their attack, particularly if they want to prevent the Patriots from dialing up pressure and forcing Young into hurried decisions.

On the other side, New England’s offense has not been particularly explosive, but they’ve shown glimpses of balance, and against a Panthers defense that has struggled to close out games, they will try to control tempo with a mix of rushing attempts and timely passes. Both defenses figure to play central roles in determining the outcome, with turnovers, third-down execution, and red-zone efficiency likely to separate winner from loser. Special teams could also swing the game in a low-scoring environment, where field position and reliable kicking matter more than usual. From a betting perspective, the total around 44.5 reflects expectations of a modest, grind-it-out game rather than an offensive showcase, which fits given the weaknesses on both sides. New England’s home-field advantage and defensive reinforcements make them the safer pick, but Carolina’s ability to create turnovers and Young’s potential for improvisational plays leaves the door open for an upset if things break their way. Ultimately, this matchup looks less like a shootout and more like a battle of attrition, where whichever team minimizes mistakes, sustains drives, and capitalizes in the red zone will emerge with a critical second win to steady their season.

Carolina Panthers NFL Preview

The Carolina Panthers enter their September 28, 2025 matchup against the New England Patriots in Foxborough knowing they’ll need to overcome adversity to earn their second win of the season, particularly with Bryce Young missing one of his most reliable targets in tight end Ja’Tavion Sanders, who is sidelined by injury. Without Sanders, the Panthers’ offensive design will shift toward leaning more heavily on their wide receivers and running backs in the passing game, requiring Young to make quick, decisive reads to avoid pressure from a Patriots defense that thrives when it can collapse the pocket. Establishing the run early will be critical, not only to keep New England honest but also to alleviate some of the burden on their young quarterback and open up play-action opportunities. Carolina’s offensive line has been inconsistent, and in a hostile road environment, their ability to limit sacks and penalties will dictate whether drives can be sustained or stall out. On defense, the Panthers must tighten up against a Patriots offense that hasn’t been flashy but has been steady enough to exploit breakdowns in coverage and extend drives with balance.

Carolina’s front seven will need to control the line of scrimmage, stuff the run, and generate pressure on the quarterback without overcommitting, as New England is adept at using screens and short passes to punish aggressive blitzing. The secondary will be tested, particularly in key third-down situations where discipline and communication must be sharp to prevent chunk plays. Special teams could be the hidden X-factor for Carolina, as flipping field position and converting kicks will be vital in what projects to be a low-scoring, grind-it-out contest. From a betting perspective, the Panthers’ 1–2 ATS record and their road inconsistency don’t inspire confidence, but if their defense forces turnovers and Young takes care of the ball, they have enough playmaking talent to keep the game close. Ultimately, Carolina’s formula for success on the road is straightforward but demanding: control tempo with the run game, protect their quarterback, play mistake-free defense, and win the hidden battles on special teams. If they execute that plan, they can give themselves a chance to pull an upset in Foxborough and avoid falling deeper into an early-season hole.

The Carolina Panthers travel to Foxborough to take on the New England Patriots on September 28, 2025, with both teams sitting at 1–2 and seeking momentum. New England enters as a modest favorite at –4.5 in the spread, with the over/under line set around 44.5.  Carolina vs New England AI Prediction: Free NFL Betting Insights for Sep 28. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

New England Patriots NFL Preview

The New England Patriots head into their September 28, 2025 matchup with the Carolina Panthers at Gillette Stadium with the advantage of home field and the motivation to even their record at 2–2 after a shaky start to the year. While New England’s pass defense has been one of the league’s weak spots through the opening three weeks, the expected return of cornerback Christian Gonzalez from a hamstring injury provides a much-needed boost to a secondary that has struggled to limit explosive plays. Offensively, the Patriots have leaned on a balanced approach, mixing steady rushing production with short, controlled passing to sustain drives and avoid putting too much pressure on their quarterback to carry the load. Against a Carolina defense that has been prone to breakdowns late in games, New England will look to establish tempo, control time of possession, and use screens and play-action to keep the Panthers’ front seven off balance.

Defensively, Bill Belichick’s group will prioritize pressuring Bryce Young, forcing him to make quick decisions without his trusted tight end Ja’Tavion Sanders, and crowding passing lanes to limit easy completions. The Patriots’ linebackers and safeties will also need to remain disciplined in containing the run, as Carolina will undoubtedly try to lean on the ground game to offset their depleted passing attack. Special teams has long been a New England strength, and in what projects to be a tight, modest-scoring contest with the total around 44.5, flipping field position or converting long field goals could be decisive. From a betting perspective, the Patriots’ 1–2 ATS record suggests they haven’t consistently rewarded backers yet, but the Panthers’ offensive injury issues and New England’s defensive reinforcements make them the safer play at –4.5 in front of their home crowd. Ultimately, the Patriots’ path to victory is clear: protect the football, execute with balance on offense, tighten up the secondary with Gonzalez back in action, and lean on Gillette Stadium’s home-field edge to grind out a crucial win that steadies their season.

Carolina vs. New England Prop Picks (AI)

Remi is pouring through tons of stats on each line. In fact, anytime the Panthers and Patriots play there’s always several intriguing observations to key in on. Not to mention games played at Gillette Stadium in Sep almost always follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: H. Henry over 38.5 Receiving Yards.

Carolina vs. New England Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over millions of data from every angle between the Panthers and Patriots and using recursive machine learning and impressive AI to examine the data to a single cover probability.

The Algorithm has been most focused on the trending factor knucklehead sportsbettors often put on New England’s strength factors between a Panthers team going up against a possibly healthy Patriots team. We’ve found the true game analytics might reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Carolina vs New England picks, computer picks Panthers vs Patriots, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Panthers Betting Trends

Carolina has a 1–2 ATS record this season, and their road ATS performance has been shaky, particularly in competitive matchups.

Patriots Betting Trends

New England is 1–2 ATS so far in 2025, with a middling cover rate that hasn’t inspired full confidence in their home spreads.

Panthers vs. Patriots Matchup Trends

The injury to Carolina’s starting tight end Ja’Tavion Sanders—who will miss this game—removes a key target from Bryce Young’s offense and may tilt value toward New England’s side. Also, Patriots cornerback Christian Gonzalez is ramping up for a return from a hamstring injury, which could strengthen a pass defense that ranks near the bottom early this season.

Carolina vs. New England Game Info

Carolina vs New England starts on September 28, 2025 at 1:00 PM EST.

Spread: New England -5.5
Moneyline: Carolina +196, New England -240
Over/Under: 43.5

Carolina: (1-2)  |  New England: (1-2)

Remi's searched hard and found the best prop for this matchup: H. Henry over 38.5 Receiving Yards.. Prices move—always shop for the best number.

The injury to Carolina’s starting tight end Ja’Tavion Sanders—who will miss this game—removes a key target from Bryce Young’s offense and may tilt value toward New England’s side. Also, Patriots cornerback Christian Gonzalez is ramping up for a return from a hamstring injury, which could strengthen a pass defense that ranks near the bottom early this season.

CAR trend: Carolina has a 1–2 ATS record this season, and their road ATS performance has been shaky, particularly in competitive matchups.

NE trend: New England is 1–2 ATS so far in 2025, with a middling cover rate that hasn’t inspired full confidence in their home spreads.

See our latest NFL picks and odds pages for 2025 to compare prices before you bet.

Carolina vs. New England Odds

Remi is pouring through mountains of data on each player. In fact, anytime the Carolina vs New England trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable betting trends.

Carolina vs New England Opening Odds

CAR Moneyline: +196
NE Moneyline: -240
CAR Spread: +5.5
NE Spread: -5.5
Over/Under: 43.5

Carolina vs New England Live Odds

Games PTS ML SPR O/U
Oct 30, 2025 8:15PM EDT
Baltimore Ravens
Miami Dolphins
10/30/25 8:15PM
Ravens
Dolphins
-420
+330
-7.5 (-115)
+7.5 (-105)
O 51.5 (-105)
U 51.5 (-115)
Nov 2, 2025 1:00PM EST
Chicago Bears
Cincinnati Bengals
11/2/25 1PM
Bears
Bengals
-154
+130
-3 (-102)
+3 (-120)
O 50.5 (-118)
U 50.5 (-104)
Nov 2, 2025 1:00PM EST
Indianapolis Colts
Pittsburgh Steelers
11/2/25 1PM
Colts
Steelers
-158
+134
-3 (-115)
+3 (-105)
O 50.5 (-104)
U 50.5 (-118)
Nov 2, 2025 1:00PM EST
Carolina Panthers
Green Bay Packers
11/2/25 1PM
Panthers
Packers
+700
-1100
+13.5 (-108)
-13.5 (-112)
O 44.5 (-105)
U 44.5 (-115)
Nov 2, 2025 1:00PM EST
Atlanta Falcons
New England Patriots
11/2/25 1PM
Falcons
Patriots
+194
-235
+5.5 (-115)
-5.5 (-105)
O 44.5 (-110)
U 44.5 (-110)
Nov 2, 2025 1:00PM EST
Denver Broncos
Houston Texans
11/2/25 1PM
Broncos
Texans
+102
-120
+1.5 (-108)
-1.5 (-112)
O 39.5 (-110)
U 39.5 (-110)
Nov 2, 2025 1:00PM EST
San Francisco 49ers
New York Giants
11/2/25 1PM
49ers
Giants
-148
+126
-2.5 (-115)
+2.5 (-105)
O 48.5 (-115)
U 48.5 (-105)
Nov 2, 2025 1:00PM EST
Los Angeles Chargers
Tennessee Titans
11/2/25 1PM
Chargers
Titans
-480
+370
-9.5 (-110)
+9.5 (-110)
O 43.5 (-105)
U 43.5 (-115)
Nov 2, 2025 1:00PM EST
Minnesota Vikings
Detroit Lions
11/2/25 1PM
Vikings
Lions
+370
-480
+8.5 (-108)
-8.5 (-112)
O 48.5 (-110)
U 48.5 (-110)
Nov 2, 2025 4:05PM EST
New Orleans Saints
Los Angeles Rams
11/2/25 4:05PM
Saints
Rams
+730
-1150
+14.5 (-115)
-14.5 (-105)
O 43.5 (-110)
U 43.5 (-110)
Nov 2, 2025 4:05PM EST
Jacksonville Jaguars
Las Vegas Raiders
11/2/25 4:05PM
Jaguars
Raiders
-158
+134
-3 (-105)
+3 (-115)
O 44.5 (-115)
U 44.5 (-105)
Nov 2, 2025 4:25PM EST
Kansas City Chiefs
Buffalo Bills
11/2/25 4:25PM
Chiefs
Bills
-134
+114
-1.5 (-114)
+1.5 (-106)
O 52.5 (-105)
U 52.5 (-115)
Nov 2, 2025 8:20PM EST
Seattle Seahawks
Washington Commanders
11/2/25 8:20PM
Seahawks
Commanders
-166
+140
-3 (-110)
+3 (-110)
O 47.5 (-112)
U 47.5 (-108)
Nov 3, 2025 8:15PM EST
Arizona Cardinals
Dallas Cowboys
11/3/25 8:15PM
Cardinals
Cowboys
+128
-152
+2.5 (-104)
-2.5 (-118)
O 53.5 (-110)
U 53.5 (-110)
Nov 6, 2025 8:15PM EST
Las Vegas Raiders
Denver Broncos
11/6/25 8:15PM
Raiders
Broncos
+370
-480
+9.5 (-115)
-9.5 (-105)
O 42.5 (-120)
U 42.5 (-102)
Nov 9, 2025 9:30AM EST
Atlanta Falcons
Indianapolis Colts
11/9/25 9:30AM
Falcons
Colts
+290
-360
+7 (-105)
-7 (-115)
O 48.5 (-108)
U 48.5 (-112)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Carolina Panthers vs. New England Patriots on September 28, 2025 at Gillette Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TB@NO TB -3.5 52.3% 1 WIN
GB@PIT GB -2.5 52.3% 1 WIN
SF@HOU SF +2.5 56.0% 6 LOSS
NYG@PHI NYG +7.5 53.9% 3 LOSS
BUF@CAR CAR +7.5 54.2% 3 LOSS
DAL@DEN DAL +3.5 55.0% 4 LOSS
MIA@ATL MIA +7 54.3% 4 WIN
CLE@NE CLE +7 56.8% 6 LOSS
TB@NO BAKER MAYFIELD OVER 15.5 RUSH YDS 56.6% 6 LOSS
MIN@LAC JUSTIN HERBERT PASS ATT UNDER 35.5 55.5% 5 WIN
TB@DET TB +6.5 54.4% 4 LOSS
TB@DET RACHAAD WHITE UNDER 14.5 RUSH ATT 54.4% 4 WIN
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS
HOU@BAL HOU -125 58.5% 7 WIN
DET@CIN DET -10 55.6% 5 WIN
DAL@NYJ NYJ +1.5 53.7% 3 LOSS
TB@SEA TB +3.5 54.9% 4 WIN
TEN@ARI ARI -7 (BUY 0.5) 54.9% 4 LOSS
DEN@PHI DEN +4.5 57.5% 7 WIN
MIA@CAR TETAIROA MCMILLAN OVER 58.5 RECV YDS 54.5% 4 WIN
LV@IND ASHTON JEANTY UNDER 67.5 RUSH YDS 54.4% 4 WIN
SF@LAR DEMARCUS ROBINSON OVER 29.5 RECV YDS 55.7% 5 WIN
NYJ@MIA NYJ +3 53.8 3 LOSS
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS