Seahawks vs Cardinals Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 25)

Updated: 2025-09-18T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Seattle Seahawks visit the Arizona Cardinals on September 25, 2025, in a pivotal Week 4 NFC West clash where both teams will vie for early divisional positioning. With the Cardinals recently losing running back James Conner to a season-ending injury, Arizona’s offense takes a hit just as Seattle looks to press its advantage.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 25, 2025

Start Time: 8:15 PM EST​

Venue: State Farm Stadium​

Cardinals Record: (2-1)

Seahawks Record: (2-1)

OPENING ODDS

SEA Moneyline: -121

ARI Moneyline: +101

SEA Spread: -1.5

ARI Spread: +1.5

Over/Under: 43.5

SEA
Betting Trends

  • The Seahawks have covered in 60% of their away games over recent seasons as road favorites or slim underdogs, especially when their defense performs.

ARI
Betting Trends

  • The Cardinals have hovered around a 50% ATS rate at home, but their struggles in the ground game and quarterback consistency have made them an underdog in many home spreads lately.

MATCHUP TRENDS

  • Seattle has covered 7 of the last 8 against NFC West foes as an underdog or road team facing less-than-dominant home teams, while Arizona is 1–5 ATS in their last six games as home underdogs. The absence of Conner will likely shift some value toward the Seahawks’ run line and lean the total toward the under unless Arizona’s passing game catches fire.

SEA vs. ARI
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Smith-Njigba under 85.5 Receiving Yards.

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Seattle vs Arizona Prediction & Odds:
Free NFL Betting Insights for 9/25/25

The September 25, 2025 matchup between the Seattle Seahawks and the Arizona Cardinals in Glendale carries heavy divisional weight early in the season, as both teams look to establish footing in the competitive NFC West while dealing with very different circumstances. Seattle enters the game with momentum and roster stability, having shown resilience in road contests and covering spreads consistently when traveling, a trend that bettors have noticed. Their formula has been balanced offensive execution—running the ball early to establish tempo and then using play-action to exploit mismatches in the secondary—combined with a defense that thrives on opportunistic turnovers and well-timed pressure. On the other side, Arizona finds itself in a more precarious position, having just lost running back James Conner to a season-ending ankle injury, a blow that reshapes their offensive identity and forces quarterback Kyler Murray to shoulder even more of the workload. Without a reliable ground game, the Cardinals risk becoming one-dimensional, relying on Murray’s arm and mobility to move the chains, which opens the door for Seattle’s defense to dial up pressures, disguise coverages, and attack the pocket to force hurried decisions.

Arizona’s receiving corps will need to step up, winning their matchups and creating separation quickly if the Cardinals hope to sustain drives and keep their defense off the field. Defensively, the Cardinals must find a way to contain Seattle’s rushing attack and prevent chunk plays off play-action, but their inconsistency against physical offensive lines has been an ongoing issue. For Seattle, the task is straightforward: protect the quarterback, lean on their backs to control clock and tempo, and trust their defense to limit Murray’s big-play potential. Special teams could also prove decisive in what may be a closer battle than the rosters suggest, with field position and kicking reliability playing major roles. From a betting standpoint, Seattle’s strong track record against the spread on the road—particularly in divisional matchups—gives them an edge, while Arizona’s 1–5 ATS record in recent home underdog situations underscores their struggles to meet expectations at State Farm Stadium. The total is likely to hover around the mid-40s, and with Arizona’s offense hampered by the loss of Conner, the under may hold more appeal unless Murray can deliver an exceptional performance. Ultimately, this game looks like a test of Seattle’s ability to capitalize on an opponent’s adversity and Arizona’s capacity to rally behind its star quarterback to prove they can still compete, but unless the Cardinals’ defense creates turnovers and Murray produces magic, the Seahawks appear better positioned to leave Glendale with a critical divisional win.

Seattle Seahawks NFL Preview

The Seattle Seahawks head into Glendale on September 25, 2025, with a prime opportunity to capitalize on an Arizona Cardinals team dealing with major offensive setbacks, most notably the season-ending injury to running back James Conner. Seattle has historically thrived in divisional road spots, covering spreads in 7 of their last 8 such contests, and they’ll look to continue that trend by leaning on their balanced offensive attack and opportunistic defense. The Seahawks’ offensive line has improved in both run blocking and pass protection, giving their quarterback the chance to execute play-action concepts effectively and exploit Arizona’s defensive secondary, which has struggled with blown coverages and explosive plays allowed. Establishing the run early will be key, not only to control tempo but also to set up vertical shots downfield that can quickly swing momentum. Defensively, Seattle is well-suited to the task of slowing Kyler Murray, who will be forced to take on more responsibility with Conner sidelined; expect the Seahawks’ pass rush to prioritize keeping contain, setting the edge, and forcing Murray to win from the pocket rather than on broken plays where he excels.

Their secondary, disciplined and physical, must stay sharp against quick slants and deep outs, knowing Murray will try to get the ball out fast against pressure. Special teams could be a hidden advantage, as Seattle has been steady in coverage units and consistent in the kicking game, which often tilts field position battles in their favor. From a betting perspective, the Seahawks’ recent success as a road underdog or slight favorite makes the moneyline and the -1.5 run line both appealing, while the under on the total may attract sharp bettors given Arizona’s offensive limitations without a reliable ground game. Ultimately, Seattle’s formula for success is straightforward: protect the quarterback, run the ball efficiently, and let their defense harass Murray into hurried decisions. If they execute that plan, the Seahawks not only have a strong chance to cover but also to leave Glendale with a divisional win that could prove critical later in the NFC West race.

The Seattle Seahawks visit the Arizona Cardinals on September 25, 2025, in a pivotal Week 4 NFC West clash where both teams will vie for early divisional positioning. With the Cardinals recently losing running back James Conner to a season-ending injury, Arizona’s offense takes a hit just as Seattle looks to press its advantage. Seattle vs Arizona AI Prediction: Free NFL Betting Insights for Sep 25. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Arizona Cardinals NFL Preview

The Arizona Cardinals enter their September 25, 2025 divisional clash against the Seattle Seahawks with their backs against the wall, facing both a tough opponent and the harsh reality of playing without star running back James Conner, whose season-ending injury reshapes the entire offensive identity of the team. In Conner’s absence, quarterback Kyler Murray becomes the focal point of everything Arizona does, and while his mobility and playmaking ability can create headaches for any defense, the increased workload also raises risks of turnovers and stalled drives if he’s pressured consistently. To offset this, the Cardinals will need creative playcalling—quick passes, screens, and tempo adjustments to spread out Seattle’s defense and avoid allowing their pass rush to dictate the game. Arizona’s receiving corps must also rise to the challenge, winning one-on-one battles and stretching the field vertically to keep the Seahawks’ secondary from sitting on short routes.

On the defensive side, the Cardinals have struggled with consistency, particularly at home where they’ve gone 1–5 ATS in their last six games as underdogs, but this matchup offers a chance for redemption if their front seven can slow Seattle’s rushing attack and force the offense into predictable third-and-long scenarios. Their defensive backs will be tested by Seattle’s play-action heavy approach, making communication and discipline paramount to avoid giving up explosive plays that can shift momentum in a hurry. Special teams could prove vital in bridging the gap, whether through big returns or clutch field goals that keep the Cardinals within striking distance. From a betting perspective, Arizona’s struggles as home underdogs make backing them risky, but divisional games often bring unpredictability, and Murray’s ability to create out of nothing gives them a fighting chance. Ultimately, the Cardinals’ path to victory lies in limiting turnovers, controlling clock with whatever run game they can muster, and leaning on Murray’s playmaking to deliver key drives in crunch time. If their defense plays disciplined football and the offense finds rhythm despite Conner’s absence, Arizona could defy the odds and secure a much-needed win to keep pace in the NFC West.

Seattle vs. Arizona Prop Picks (AI)

AI algorithm Remi is pouring through tons of datapoints on each player. In fact, anytime the Seahawks and Cardinals play there’s always several intriguing observations to key in on. Not to mention games played at State Farm Stadium in Sep can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: J. Smith-Njigba under 85.5 Receiving Yards.

Seattle vs. Arizona Prediction (AI)

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Remi, our AI sports genius, has been pouring over mountains of data from every simulation between the Seahawks and Cardinals and using recursive machine learning and cutting-edge AI to analyze the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most focused on the unproportionally assigned emphasis emotional bettors often put on Seattle’s strength factors between a Seahawks team going up against a possibly tired Cardinals team. In reality, the true game analytics might reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Seattle vs Arizona picks, computer picks Seahawks vs Cardinals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Seahawks Betting Trends

The Seahawks have covered in 60% of their away games over recent seasons as road favorites or slim underdogs, especially when their defense performs.

Cardinals Betting Trends

The Cardinals have hovered around a 50% ATS rate at home, but their struggles in the ground game and quarterback consistency have made them an underdog in many home spreads lately.

Seahawks vs. Cardinals Matchup Trends

Seattle has covered 7 of the last 8 against NFC West foes as an underdog or road team facing less-than-dominant home teams, while Arizona is 1–5 ATS in their last six games as home underdogs. The absence of Conner will likely shift some value toward the Seahawks’ run line and lean the total toward the under unless Arizona’s passing game catches fire.

Seattle vs. Arizona Game Info

Seattle vs Arizona starts on September 25, 2025 at 8:15 PM EST.

Venue: State Farm Stadium.

Spread: Arizona +1.5
Moneyline: Seattle -121, Arizona +101
Over/Under: 43.5

Seattle: (2-1)  |  Arizona: (2-1)

Remi's searched hard and found the best prop for this matchup: J. Smith-Njigba under 85.5 Receiving Yards.. Prices move—always shop for the best number.

Seattle has covered 7 of the last 8 against NFC West foes as an underdog or road team facing less-than-dominant home teams, while Arizona is 1–5 ATS in their last six games as home underdogs. The absence of Conner will likely shift some value toward the Seahawks’ run line and lean the total toward the under unless Arizona’s passing game catches fire.

SEA trend: The Seahawks have covered in 60% of their away games over recent seasons as road favorites or slim underdogs, especially when their defense performs.

ARI trend: The Cardinals have hovered around a 50% ATS rate at home, but their struggles in the ground game and quarterback consistency have made them an underdog in many home spreads lately.

See our latest NFL picks and odds pages for 2025 to compare prices before you bet.

Seattle vs. Arizona Odds

Remi is pouring through loads of data on each player. In fact, anytime the Seattle vs Arizona trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable betting trends.

Seattle vs Arizona Opening Odds

SEA Moneyline: -121
ARI Moneyline: +101
SEA Spread: -1.5
ARI Spread: +1.5
Over/Under: 43.5

Seattle vs Arizona Live Odds

Games PTS ML SPR O/U
Oct 30, 2025 8:15PM EDT
Baltimore Ravens
Miami Dolphins
10/30/25 8:15PM
Ravens
Dolphins
-440
+344
-7.5 (-110)
+7.5 (-110)
O 51 (-105)
U 51 (-115)
Nov 2, 2025 1:00PM EST
Chicago Bears
Cincinnati Bengals
11/2/25 1PM
Bears
Bengals
-160
+140
-2.5 (-125)
+2.5 (+105)
O 51.5 (-104)
U 51.5 (-116)
Nov 2, 2025 1:00PM EST
Indianapolis Colts
Pittsburgh Steelers
11/2/25 1PM
Colts
Steelers
-171
+150
-3 (-117)
+3 (-103)
O 50.5 (-110)
U 50.5 (-110)
Nov 2, 2025 1:00PM EST
Carolina Panthers
Green Bay Packers
11/2/25 1PM
Panthers
Packers
+613
-900
+13 (-105)
-13 (-115)
O 44 (-110)
U 44 (-110)
Nov 2, 2025 1:00PM EST
Atlanta Falcons
New England Patriots
11/2/25 1PM
Falcons
Patriots
+207
-250
+5 (-105)
-5 (-115)
O 45 (-110)
U 45 (-110)
Nov 2, 2025 1:00PM EST
Denver Broncos
Houston Texans
11/2/25 1PM
Broncos
Texans
+105
-125
+1 (+100)
-1 (-120)
O 40 (-110)
U 40 (-110)
Nov 2, 2025 1:00PM EST
San Francisco 49ers
New York Giants
11/2/25 1PM
49ers
Giants
-147
+127
-2.5 (-115)
+2.5 (-105)
O 49 (-103)
U 49 (-117)
Nov 2, 2025 1:00PM EST
Los Angeles Chargers
Tennessee Titans
11/2/25 1PM
Chargers
Titans
-500
+383
-9.5 (-105)
+9.5 (-115)
O 43.5 (-108)
U 43.5 (-112)
Nov 2, 2025 1:00PM EST
Minnesota Vikings
Detroit Lions
11/2/25 1PM
Vikings
Lions
+374
-485
+9 (-110)
-9 (-110)
O 47.5 (-117)
U 47.5 (-103)
Nov 2, 2025 4:05PM EST
New Orleans Saints
Los Angeles Rams
11/2/25 4:05PM
Saints
Rams
+754
-1200
+13.5 (+100)
-13.5 (-120)
O 44 (-107)
U 44 (-113)
Nov 2, 2025 4:05PM EST
Jacksonville Jaguars
Las Vegas Raiders
11/2/25 4:05PM
Jaguars
Raiders
-150
+130
-3 (+100)
+3 (-120)
O 44.5 (-110)
U 44.5 (-110)
Nov 2, 2025 4:25PM EST
Kansas City Chiefs
Buffalo Bills
11/2/25 4:25PM
Chiefs
Bills
-130
+110
-2 (-110)
+2 (-110)
O 52.5 (-110)
U 52.5 (-110)
Nov 2, 2025 8:20PM EST
Seattle Seahawks
Washington Commanders
11/2/25 8:20PM
Seahawks
Commanders
-163
+143
-3 (-113)
+3 (-107)
O 48 (-110)
U 48 (-110)
Nov 3, 2025 8:15PM EST
Arizona Cardinals
Dallas Cowboys
11/3/25 8:15PM
Cardinals
Cowboys
+130
-150
+2.5 (-105)
-2.5 (-115)
O 53.5 (-105)
U 53.5 (-115)
Nov 6, 2025 8:15PM EST
Las Vegas Raiders
Denver Broncos
11/6/25 8:15PM
Raiders
Broncos
+370
-480
+9.5 (-106)
-9.5 (-114)
O 42.5 (-110)
U 42.5 (-110)
Nov 9, 2025 9:30AM EST
Atlanta Falcons
Indianapolis Colts
11/9/25 9:30AM
Falcons
Colts
+290
-360
+7 (-106)
-7 (-114)
O 48.5 (-110)
U 48.5 (-110)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Seattle Seahawks vs. Arizona Cardinals on September 25, 2025 at State Farm Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TB@NO TB -3.5 52.3% 1 WIN
GB@PIT GB -2.5 52.3% 1 WIN
SF@HOU SF +2.5 56.0% 6 LOSS
NYG@PHI NYG +7.5 53.9% 3 LOSS
BUF@CAR CAR +7.5 54.2% 3 LOSS
DAL@DEN DAL +3.5 55.0% 4 LOSS
MIA@ATL MIA +7 54.3% 4 WIN
CLE@NE CLE +7 56.8% 6 LOSS
TB@NO BAKER MAYFIELD OVER 15.5 RUSH YDS 56.6% 6 LOSS
MIN@LAC JUSTIN HERBERT PASS ATT UNDER 35.5 55.5% 5 WIN
TB@DET TB +6.5 54.4% 4 LOSS
TB@DET RACHAAD WHITE UNDER 14.5 RUSH ATT 54.4% 4 WIN
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS
HOU@BAL HOU -125 58.5% 7 WIN
DET@CIN DET -10 55.6% 5 WIN
DAL@NYJ NYJ +1.5 53.7% 3 LOSS
TB@SEA TB +3.5 54.9% 4 WIN
TEN@ARI ARI -7 (BUY 0.5) 54.9% 4 LOSS
DEN@PHI DEN +4.5 57.5% 7 WIN
MIA@CAR TETAIROA MCMILLAN OVER 58.5 RECV YDS 54.5% 4 WIN
LV@IND ASHTON JEANTY UNDER 67.5 RUSH YDS 54.4% 4 WIN
SF@LAR DEMARCUS ROBINSON OVER 29.5 RECV YDS 55.7% 5 WIN
NYJ@MIA NYJ +3 53.8 3 LOSS
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS