Lions vs. Ravens
Prediction, Odds & Props
Sep 22 | NFL AI Picks

Updated: 2025-09-15T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Detroit Lions (1-1) will travel to Baltimore to take on the Ravens (1-1) in a Monday Night Football game with plenty of buzz, as both teams have shown flashes early in the season but also clear areas for improvement. Baltimore is favored by around 5.5 points, with the over/under in the low 50s (~51.5), signaling expectations for a moderately high-scoring game.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 22, 2025

Start Time: 8:15 PM EST​

Venue: M&T Bank Stadium​

Ravens Record: (1-1)

Lions Record: (1-1)

OPENING ODDS

DET Moneyline: +198

BAL Moneyline: -242

DET Spread: +5.5

BAL Spread: -5.5

Over/Under: 51.5

DET
Betting Trends

  • Detroit has shown potential to cover as underdogs in certain matchups; analysts previewing this game expect the Lions to be able to cover against Baltimore given injuries and potential defensive vulnerabilities on the Ravens.

BAL
Betting Trends

  • Baltimore’s home against-the-spread record since 2022 is modest, standing around 13-14-1, indicating that while they win many games at home, they do not always beat the spread, particularly in games where their margin of victory is expected to be large.

MATCHUP TRENDS

  • This matchup has several betting storylines: Detroit’s offense has looked explosive recently, which may make the over attractive; Baltimore, meanwhile, is missing key defensive pieces, which gives hope to Lions backers. The point spread being ~5.5 suggests the market expects a close game, not a blowout, despite Baltimore’s home-field advantage. Also, given Ravens’ mixed history covering large spreads at home, there could be value in Detroit staying close.

DET vs. BAL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Gibbs over 62.5 Rushing Yards.

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Detroit vs Baltimore Prediction & Odds:
Free NFL Betting Insights for 9/22/25

The upcoming Week 3 Monday Night Football clash between the Detroit Lions and the Baltimore Ravens on September 22, 2025, sets the stage for a compelling battle between two teams trying to define their identities early in the season, and it feels like a matchup that could swing the trajectory of either franchise depending on how it unfolds. The Lions, fresh off a high-powered win over Chicago, come into this game with confidence in their offense as Jared Goff looks in rhythm and his receiving corps, led by Amon-Ra St. Brown, continues to find mismatches downfield, while their young backfield tandem of Jahmyr Gibbs and Javonte Williams provides balance to an attack that has become difficult to defend when the offensive line plays to its potential. Detroit’s challenge, however, will be on the other side of the ball, as their defense still has lingering questions about whether it can stop elite quarterbacks, especially those who thrive on mobility and improvisation, which makes facing Lamar Jackson and Baltimore’s scheme a true test of progress. The Ravens, meanwhile, responded to their Week 1 setback against Buffalo with a resounding win over Cleveland, and Jackson reminded the league why he is still one of the most dangerous dual-threat quarterbacks in football, combining his arm strength with his ability to extend plays with his legs, and Derrick Henry’s presence has given this offense a bruising element that forces defenses to stay honest between the tackles.

What makes this matchup so intriguing is that Baltimore’s defense, though traditionally a strength, has shown vulnerability against dynamic passing offenses, and Detroit’s vertical attack could exploit that if Goff has time in the pocket, while the Ravens’ own ability to generate pressure and force turnovers could flip the script if the Lions struggle to protect their quarterback. The chess match between Dan Campbell’s aggressive play-calling and John Harbaugh’s situational mastery promises to keep fans on edge, as both coaches are known for bold decisions that can swing momentum instantly, whether through fourth-down attempts, trick plays, or creative blitz packages. Special teams could play a large role as well, with Justin Tucker still one of the most reliable kickers in the league and Detroit needing to maximize field position to avoid giving Jackson short fields, and turnovers will likely determine who walks away victorious. The spread hovering around 5.5 in Baltimore’s favor indicates that oddsmakers expect a competitive game but lean toward the Ravens’ home advantage and track record of winning tight matchups at M&T Bank Stadium. For Detroit to pull off the upset, their defense must contain Jackson enough to force third-and-longs while their offensive line must dominate in the trenches to keep Goff upright, whereas Baltimore will focus on sustaining long, grinding drives and limiting Detroit’s explosive plays to tilt the clock and control tempo. In the end, this is a classic battle of a rising team trying to prove it belongs against a perennial contender eager to solidify its dominance, and while the Ravens enter as the favorite, the Lions’ recent surge suggests that this could come down to execution in the final minutes, where one big play or mistake will decide whether it becomes a signature Detroit upset or another Baltimore home triumph.

Detroit Lions NFL Preview

The Detroit Lions enter this matchup against the Baltimore Ravens with a mix of optimism and urgency, knowing that they have the talent to compete with one of the AFC’s elite teams but needing to prove that their offensive firepower can consistently translate against defenses as fast and physical as Baltimore’s. Jared Goff has looked sharp to start the season, distributing the ball with efficiency and confidence, and Amon-Ra St. Brown continues to emerge as a premier wide receiver capable of taking over games, particularly when given favorable matchups in the slot. The offensive line, led by Penei Sewell, has been a cornerstone of Detroit’s recent success, giving Goff both time to operate and opening running lanes for their versatile backfield, which combines the quickness of Jahmyr Gibbs with the downhill power of Javonte Williams. Detroit’s offense has been most dangerous when establishing balance early, forcing defenses to respect both the run and pass, but against Baltimore, that balance will be tested, as the Ravens pride themselves on collapsing pockets and forcing quarterbacks into mistakes with disguised blitzes and heavy pressure. Defensively, the Lions are still a work in progress, and their ability to handle Lamar Jackson will dictate whether they can stay competitive or risk being overwhelmed by Baltimore’s multifaceted attack.

Aidan Hutchinson and the defensive front must generate consistent pressure while containing Jackson’s scrambling lanes, something easier said than done given his elusiveness and the addition of Derrick Henry as a punishing runner who can control tempo if Detroit overcommits to stopping the pass. The secondary, which has shown flashes of improvement but remains prone to breakdowns, will need to step up against Baltimore’s receiving corps and tight ends, especially in red zone situations where Jackson’s improvisation often leads to back-breaking plays. For Detroit, the key will be avoiding self-inflicted wounds, such as turnovers or missed assignments, while taking calculated risks to keep the Ravens off balance, whether through aggressive fourth-down attempts or blitz packages designed to disrupt timing. Dan Campbell’s fearless coaching style has fueled the Lions’ recent rise, and he will likely keep his team aggressive in this environment, understanding that playing conservative against a team like Baltimore rarely leads to victory. If Goff can stay upright and the offensive rhythm clicks early, Detroit has the weapons to turn this into a shootout where their skill players shine, but if Baltimore’s defense forces them into predictable situations, the Lions risk falling behind quickly. Ultimately, this game represents a measuring stick for Detroit’s progression from an up-and-coming contender to a team that can genuinely challenge the AFC’s best, and while the odds tilt toward the Ravens at home, the Lions’ ability to generate explosive plays and keep composure in a hostile atmosphere will determine whether they leave with a statement win or a sobering reminder of how much work still lies ahead.

The Detroit Lions (1-1) will travel to Baltimore to take on the Ravens (1-1) in a Monday Night Football game with plenty of buzz, as both teams have shown flashes early in the season but also clear areas for improvement. Baltimore is favored by around 5.5 points, with the over/under in the low 50s (~51.5), signaling expectations for a moderately high-scoring game.   Detroit vs Baltimore AI Prediction: Free NFL Betting Insights for Sep 22. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Baltimore Ravens NFL Preview

The Baltimore Ravens enter this primetime matchup against the Detroit Lions with confidence and momentum, ready to showcase their physicality and balance in front of a home crowd that has come to expect nothing less than dominance. Lamar Jackson continues to be the centerpiece of the Ravens’ attack, combining his dual-threat ability with improved pocket passing that has made the offense even more difficult to defend. With the addition of Derrick Henry in the backfield, Baltimore has a one-two punch that few defenses can handle, as Henry’s bruising style wears down front sevens while Jackson keeps them honest with his scrambling and play-action prowess. The offensive line, anchored by Ronnie Stanley, has held up well despite injuries in recent seasons, and their ability to control the line of scrimmage will be key in keeping Detroit’s pass rush at bay. Baltimore’s receiving corps, led by Zay Flowers and Mark Andrews, has given Jackson more reliable targets, making the red zone offense particularly lethal and forcing defenses into difficult choices between stacking the box or dropping into coverage. Defensively, the Ravens remain one of the league’s most respected units, built on speed, physicality, and a knack for creating turnovers. The secondary, featuring Kyle Hamilton and Marlon Humphrey, will be tasked with containing Amon-Ra St. Brown and limiting Detroit’s explosive passing plays, while the defensive front, led by Justin Madubuike, will look to collapse the pocket and disrupt Jared Goff’s rhythm early and often.

Baltimore’s linebackers, especially Roquan Smith, are the glue of this defense, capable of filling running lanes against Gibbs and Williams while still excelling in pass coverage. Playing at home gives the Ravens an added edge, as M&T Bank Stadium is notoriously difficult for visiting teams, and their fan base knows how to create a hostile environment that amplifies Baltimore’s aggressive style of play. For coach John Harbaugh, the emphasis will be on sticking to the Ravens’ identity of physical football while also exploiting Detroit’s weaknesses, particularly their inconsistent secondary and reliance on offensive rhythm. If Baltimore can force early turnovers or establish a lead through sustained drives, they have the personnel to suffocate teams by controlling possession and letting their defense pin their ears back. However, Harbaugh will also understand the need to respect Detroit’s offensive explosiveness, as Goff and his playmakers are more than capable of turning momentum with a big strike if given opportunities. The Ravens’ formula has always been built on discipline and execution, and in a matchup like this, where playoff implications and pride are both at stake, their experience and depth could prove decisive. Ultimately, the Ravens have the advantage of continuity, a balanced roster, and the type of quarterback that can break games wide open, giving them a strong chance to defend their home field and remind the rest of the NFL that Baltimore remains one of the premier franchises built to win now and into the future.

Detroit vs. Baltimore Prop Picks (AI)

Remi is pouring through tons of stats on each line. In fact, anytime the Lions and Ravens play there’s always several intriguing angles to key in on. Not to mention games played at M&T Bank Stadium in Sep seemingly never follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: J. Gibbs over 62.5 Rushing Yards.

Detroit vs. Baltimore Prediction (AI)

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Remi, our AI sports genius, has been pouring over millions of data from every past game between the Lions and Ravens and using recursive machine learning and impressive AI to analyze the data to a single cover probability.

The Algorithm has been most watching on the linear correlation of emphasis knucklehead sportsbettors regularly put on player performance factors between a Lions team going up against a possibly unhealthy Ravens team. Trends look to say the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Detroit vs Baltimore picks, computer picks Lions vs Ravens, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NFL 10/9 PHI@NYG UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Lions Betting Trends

Detroit has shown potential to cover as underdogs in certain matchups; analysts previewing this game expect the Lions to be able to cover against Baltimore given injuries and potential defensive vulnerabilities on the Ravens.

Ravens Betting Trends

Baltimore’s home against-the-spread record since 2022 is modest, standing around 13-14-1, indicating that while they win many games at home, they do not always beat the spread, particularly in games where their margin of victory is expected to be large.

Lions vs. Ravens Matchup Trends

This matchup has several betting storylines: Detroit’s offense has looked explosive recently, which may make the over attractive; Baltimore, meanwhile, is missing key defensive pieces, which gives hope to Lions backers. The point spread being ~5.5 suggests the market expects a close game, not a blowout, despite Baltimore’s home-field advantage. Also, given Ravens’ mixed history covering large spreads at home, there could be value in Detroit staying close.

Detroit vs. Baltimore Game Info

Detroit vs Baltimore starts on September 22, 2025 at 8:15 PM EST.

Spread: Baltimore -5.5
Moneyline: Detroit +198, Baltimore -242
Over/Under: 51.5

Detroit: (1-1)  |  Baltimore: (1-1)

Remi's searched hard and found the best prop for this matchup: J. Gibbs over 62.5 Rushing Yards.. Prices move—always shop for the best number.

This matchup has several betting storylines: Detroit’s offense has looked explosive recently, which may make the over attractive; Baltimore, meanwhile, is missing key defensive pieces, which gives hope to Lions backers. The point spread being ~5.5 suggests the market expects a close game, not a blowout, despite Baltimore’s home-field advantage. Also, given Ravens’ mixed history covering large spreads at home, there could be value in Detroit staying close.

DET trend: Detroit has shown potential to cover as underdogs in certain matchups; analysts previewing this game expect the Lions to be able to cover against Baltimore given injuries and potential defensive vulnerabilities on the Ravens.

BAL trend: Baltimore’s home against-the-spread record since 2022 is modest, standing around 13-14-1, indicating that while they win many games at home, they do not always beat the spread, particularly in games where their margin of victory is expected to be large.

See our latest NFL picks and odds pages for 2025 to compare prices before you bet.

Detroit vs. Baltimore Odds

AI algorithm Remi is pouring through loads of data points on each player. In fact, anytime the Detroit vs Baltimore trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable betting trends.

Detroit vs Baltimore Opening Odds

DET Moneyline: +198
BAL Moneyline: -242
DET Spread: +5.5
BAL Spread: -5.5
Over/Under: 51.5

Detroit vs Baltimore Live Odds

Games PTS ML SPR O/U
Oct 9, 2025 8:15PM EDT
Philadelphia Eagles
New York Giants
10/9/25 8:15PM
Eagles
Giants
-400
+315
-7.5 (-104)
+7.5 (-118)
O 40.5 (-115)
U 40.5 (-105)
Oct 12, 2025 9:30AM EDT
Denver Broncos
New York Jets
10/12/25 9:30AM
Broncos
Jets
-405
+320
-7 (-118)
+7 (-104)
O 43.5 (-105)
U 43.5 (-115)
Oct 12, 2025 1:00PM EDT
Seattle Seahawks
Jacksonville Jaguars
10/12/25 1PM
Seahawks
Jaguars
-104
-112
+1.5 (-120)
-1.5 (-102)
O 47.5 (-105)
U 47.5 (-115)
Oct 12, 2025 1:00PM EDT
New England Patriots
New Orleans Saints
10/12/25 1PM
Patriots
Saints
-180
+152
-3.5 (-105)
+3.5 (-115)
O 45.5 (-115)
U 45.5 (-105)
Oct 12, 2025 1:01PM EDT
Cleveland Browns
Pittsburgh Steelers
10/12/25 1:01PM
Browns
Steelers
+225
-275
+5.5 (-102)
-5.5 (-120)
O 38.5 (-108)
U 38.5 (-112)
Oct 12, 2025 1:01PM EDT
Los Angeles Chargers
Miami Dolphins
10/12/25 1:01PM
Chargers
Dolphins
-190
+160
-4.5 (-102)
+4.5 (-120)
O 43.5 (-112)
U 43.5 (-108)
Oct 12, 2025 1:01PM EDT
Los Angeles Rams
Baltimore Ravens
10/12/25 1:01PM
Rams
Ravens
-370
+295
-7.5 (-105)
+7.5 (-115)
O 44.5 (-115)
U 44.5 (-105)
Oct 12, 2025 1:01PM EDT
Dallas Cowboys
Carolina Panthers
10/12/25 1:01PM
Cowboys
Panthers
-172
+144
-3 (-120)
+3 (-102)
O 49.5 (-108)
U 49.5 (-112)
Oct 12, 2025 1:01PM EDT
Arizona Cardinals
Indianapolis Colts
10/12/25 1:01PM
Cardinals
Colts
+295
-370
+7.5 (-115)
-7.5 (-105)
O 46.5 (-110)
U 46.5 (-110)
Oct 12, 2025 4:06PM EDT
Tennessee Titans
Las Vegas Raiders
10/12/25 4:06PM
Titans
Raiders
+180
-215
+4.5 (-110)
-4.5 (-110)
O 41.5 (-108)
U 41.5 (-112)
Oct 12, 2025 4:26PM EDT
Cincinnati Bengals
Green Bay Packers
10/12/25 4:26PM
Bengals
Packers
+730
-1150
+14.5 (-115)
-14.5 (-105)
O 44.5 (-104)
U 44.5 (-118)
Oct 12, 2025 4:26PM EDT
San Francisco 49ers
Tampa Bay Buccaneers
10/12/25 4:26PM
49ers
Buccaneers
+130
-154
+3 (-115)
-3 (-105)
O 47.5 (-108)
U 47.5 (-112)
Oct 12, 2025 8:20PM EDT
Detroit Lions
Kansas City Chiefs
10/12/25 8:20PM
Lions
Chiefs
+118
-138
+2.5 (-110)
-2.5 (-110)
O 52.5 (-110)
U 52.5 (-110)
Oct 13, 2025 7:15PM EDT
Buffalo Bills
Atlanta Falcons
10/13/25 7:15PM
Bills
Falcons
-230
+190
-4.5 (-115)
+4.5 (-105)
O 49.5 (-115)
U 49.5 (-105)
Oct 13, 2025 8:16PM EDT
Chicago Bears
Washington Commanders
10/13/25 8:16PM
Bears
Commanders
+188
-225
+4.5 (-112)
-4.5 (-108)
O 49.5 (-115)
U 49.5 (-105)
Oct 16, 2025 8:16PM EDT
Pittsburgh Steelers
Cincinnati Bengals
10/16/25 8:16PM
Steelers
Bengals
-230
+190
-4.5 (-112)
+4.5 (-108)
O 42.5 (-115)
U 42.5 (-105)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Detroit Lions vs. Baltimore Ravens on September 22, 2025 at M&T Bank Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
HOU@BAL HOU -125 58.5% 7 WIN
DET@CIN DET -10 55.6% 5 WIN
DAL@NYJ NYJ +1.5 53.7% 3 LOSS
TB@SEA TB +3.5 54.9% 4 WIN
TEN@ARI ARI -7 (BUY 0.5) 54.9% 4 LOSS
DEN@PHI DEN +4.5 57.5% 7 WIN
MIA@CAR TETAIROA MCMILLAN OVER 58.5 RECV YDS 54.5% 4 WIN
LV@IND ASHTON JEANTY UNDER 67.5 RUSH YDS 54.4% 4 WIN
SF@LAR DEMARCUS ROBINSON OVER 29.5 RECV YDS 55.7% 5 WIN
NYJ@MIA NYJ +3 53.8 3 LOSS
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS
TEN@HOU TEN +7.5 57.9% 7 LOSS
LAC@NYG LAC -6 57.3% 7 LOSS
NO@BUF UNDER 48.5 55.1% 3 LOSS
GB@DAL JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS 55.5% 5 LOSS
CAR@NE DRAKE MAYE TO THROW AN INT 56.6% 6 LOSS
SEA@ARI SEA -125 57.7% 6 WIN
SEA@ARI KYLER MURRAY TO THROW AN INT 56.6% 6 WIN
DET@BAL JAHMYR GIBBS OVER 0.5 RUSH TDS 55.8% 5 WIN
DAL@CHI DAL -120 58.7% 6 LOSS
PIT@NE PIT -116 60.1% 6 WIN
ATL@CAR ATL -4.5 55.4% 5 LOSS
LV@WAS LV +3 54.3% 4 LOSS
GB@CLE GB -7 54.3% 4 LOSS
ARI@SF ARI +3 57.7% 6 WIN
KC@NYG PATRICK MAHOMES OVER 230.5 PASS YDS 54.7% 4 WIN
GB@CLE JOE FLACCO OVER 37.5 PASS ATT 56.6% 6 LOSS
MIA@BUF TYREEK HILL OVER 5.5 TOTAL RECEPTIONS 56.8% 6 LOSS
LAC@LV LAC -3 54.9% 4 WIN
TB@HOU BAKER MAYFIELD OVER 1.5 PASS TDS 54.4% 4 WIN
CHI@DET DET -6.5 54.3% 4 WIN
DEN@IND DEN -118 60.1% 10 LOSS
PHI@KC PHI -115 56.7% 6 WIN
SF@NO SF -3 58.8% 8 WIN
SEA@PIT OVER 40 54.9% 4 WIN
CAR@ARI BRYCE YOUNG INTERCEPTIONS UNDER 0.5 56.4% 6 LOSS
DEN@IND JOSH DOWNS RECEPTIONS OVER 3.5 54.7% 4 WIN
ATL@MIN BIJAN ROBINSON RUSH + REC YDS OVER 94.5 53.4% 3 WIN
WAS@GB WAS +3.5 56.5% 6 LOSS
WAS@GB JORDAN LOVE OVER 5.5 RUSH YDS 54.7% 4 WIN
MIN@CHI CALEB WILLIAMS OVER 219.5 PASS YDS 53.4% 3 LOSS
TEN@DEN DEN -8.5 55.3% 5 LOSS
SF@SEA SF -115 54.6% 4 WIN
SF@SEA KENNETH WALKER III UNDER 79.5 RUSH+REC YDS 54.6% 4 WIN
CAR@JAC TANK BIGSBY OVER 10.5 RUSH ATT 56.1% 6 LOSS