Saints vs Seahawks Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 21)

Updated: 2025-09-14T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The New Orleans Saints (0-2) hit the road to take on the Seattle Seahawks (1-1) in Week 3 in what has become a crucial test early in the season. Seattle comes in as about a 7-point favorite, and the over/under is set around 41.5 points, suggesting that bookies expect a moderately low-scoring affair.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 21, 2025

Start Time: 4:05 PM EST​

Venue: Lumen Field​

Seahawks Record: (1-1)

Saints Record: (0-2)

OPENING ODDS

NO Moneyline: +308

SEA Moneyline: -391

NO Spread: +7.5

SEA Spread: -7.5

Over/Under: 41.5

NO
Betting Trends

  • New Orleans has struggled to cover early this season, particularly in games where the offense couldn’t finish drives or kept turning the ball over. Their 0-2 start has been marked by close losses and missed opportunities, like failing on a key fourth-and-2 late against San Francisco.

SEA
Betting Trends

  • The Seahawks, meanwhile, have been better trusted by bettors at home when their defense sets the tone early. Coming off of a 31-17 win in Week 2 over the Steelers, their home crowd and familiarity with Lumen Field could help them stay composed and cover as favorites.

MATCHUP TRENDS

  • In the Saints-Seahawks series, despite Seattle holding the overall series lead, New Orleans has won the last four matchups. Many of those wins came by close margins, and recent betting lines show Seattle as favorites by about a touchdown, indicating bettors expect them to win, but perhaps not dominate. Also relevant: Seattle is favored by 7, and the projected total around 41.5 suggests this game might stay tight, with defenses likely to play a big role.

NO vs. SEA
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: A. Kamara over 52.5 Rushing Yards.

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New Orleans vs Seattle Prediction & Odds:
Free NFL Betting Insights for 9/21/25

The Week 3 matchup between the New Orleans Saints and the Seattle Seahawks on September 21, 2025, at Lumen Field carries significant intrigue as both teams look to solidify their early season identities, with Seattle entering at 1-1 after an impressive Week 2 win and New Orleans searching for its first victory at 0-2. The Saints have shown flashes of competitiveness but have been plagued by missed opportunities and inconsistent execution, as evidenced by their inability to score late against the 49ers despite racking up over 300 total yards; their rookie quarterback Spencer Rattler has been composed and turnover-averse, but injuries to playmakers such as Alvin Kamara and Chris Olave have left the offense shorthanded and forced the coaching staff to lean more heavily on depth players who have yet to find consistency. Their defense has performed admirably in stretches, especially against the run, but has struggled with discipline and situational stops late in games, and against a balanced Seahawks offense that thrives on time-of-possession dominance and strong red-zone efficiency, that could be problematic. Seattle, meanwhile, comes off a 31-17 win over Pittsburgh where their defense forced multiple three-and-outs and the offense looked balanced with Kenneth Walker III pounding the run game and Geno Smith connecting with DK Metcalf and Tyler Lockett to keep chains moving; the Seahawks are also historically tough at home, with the energy at Lumen Field often giving them a mental edge that translates to a physical one in contested games.

While the Seahawks are favored by about a touchdown and the projected point total of 41.5 suggests a lower-scoring tilt, the Saints’ recent history of beating Seattle in four straight meetings could provide some confidence, though most of those came with healthier rosters and steadier execution than what New Orleans currently brings. Key matchups to watch include the Saints’ offensive line, which must protect Rattler against a Seahawks pass rush that thrives on noise and speed, as well as New Orleans’ secondary against Seattle’s receiving duo, with one or two explosive plays likely to swing momentum. Turnover margin, which has hurt New Orleans so far, could be decisive, and the Saints will need to force at least one defensive takeaway to have a chance. Overall, this game shapes up as a battle between Seattle’s proven home-field edge and roster stability against New Orleans’ search for consistency and identity, and while the Seahawks seem positioned to take care of business, the Saints’ history of pushing them could keep the spread in play if they clean up mistakes and sustain drives.

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New Orleans Saints NFL Preview

The New Orleans Saints enter this matchup against the Seattle Seahawks with plenty to prove as they try to avoid falling into an 0-3 hole to start the 2025 season, and their focus will be on shoring up both consistency and execution after two close but disappointing losses. Led by rookie quarterback Spencer Rattler, the Saints’ offense has not been without promise, as Rattler has displayed poise in the pocket and avoided costly turnovers, but the lack of continuity at the skill positions due to injuries has held back their overall effectiveness. Alvin Kamara’s status remains in question, and his absence or limited availability greatly impacts the Saints’ ability to both run the football and use him as a versatile weapon in the passing game, leaving a heavier load on Rattler to connect with a receiving corps missing Chris Olave and relying on secondary options to create separation. That puts extra pressure on the offensive line, which has struggled in spots against pressure-heavy defenses, and Seattle’s ability to generate pass rush at home in front of a loud crowd could create the type of disruption that derails drives and forces quick punts. Defensively, New Orleans has been competitive, with the front seven limiting rushing lanes and keeping opposing ground games from dominating, but they have struggled with situational stops, particularly on third downs and in the red zone, which has led to extended drives and late-game breakdowns.

Facing Geno Smith, DK Metcalf, and Tyler Lockett will test the Saints’ secondary, which has been inconsistent in coverage and vulnerable to giving up chunk plays through the air. For New Orleans to stay competitive, the key lies in creating takeaways, an area where they have fallen short early in the season, and flipping the field to give their offense shorter scoring opportunities. If the Saints’ defense can generate turnovers and their offensive line can hold up enough for Rattler to find rhythm with his receivers, New Orleans has the potential to make this a competitive game. Their recent history of success against the Seahawks, including four straight victories in past meetings, provides some confidence despite the underdog status, but this version of the team is younger, banged up, and still finding its footing. To pull off the upset, the Saints will need near-flawless execution, limit penalties that have stalled drives, and find a way to establish a running game to balance their offense and keep Seattle’s defense honest. While the odds and environment are stacked against them, New Orleans has shown flashes of resilience, and if Rattler continues his growth trajectory, the Saints may have enough to at least keep the spread close and give themselves a shot at their first win of the season.

The New Orleans Saints (0-2) hit the road to take on the Seattle Seahawks (1-1) in Week 3 in what has become a crucial test early in the season. Seattle comes in as about a 7-point favorite, and the over/under is set around 41.5 points, suggesting that bookies expect a moderately low-scoring affair.  New Orleans vs Seattle AI Prediction: Free NFL Betting Insights for Sep 21. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Seattle Seahawks NFL Preview

The Seattle Seahawks enter this matchup against the New Orleans Saints with confidence and momentum, having opened the season 2-0 behind a combination of efficient offense, timely defense, and the undeniable energy of playing in front of one of the NFL’s toughest home-field environments. Quarterback Geno Smith has settled into his role as a steady leader of the offense, spreading the ball effectively between DK Metcalf, Tyler Lockett, and Jaxon Smith-Njigba, while also utilizing his running backs to keep defenses off balance. The passing attack has been particularly efficient on third downs, extending drives and wearing down opposing defenses, which is a crucial element when facing a Saints unit that has been inconsistent at getting off the field in high-pressure moments. Seattle’s offensive line, often a source of questions in recent seasons, has performed better than expected in pass protection and has allowed Smith the necessary time to read defenses and take calculated shots downfield. The ground game, spearheaded by Kenneth Walker III and supported by rookie Zach Charbonnet, provides balance and has allowed the Seahawks to control tempo, a strategy that should be critical against a Saints defense that has been vulnerable to extended possessions.

Defensively, Seattle continues to thrive under Pete Carroll’s aggressive approach, with a front seven that applies steady pressure and a secondary anchored by Tariq Woolen, who has developed into one of the league’s top young corners. This group will be tested by a New Orleans offense that, while not at full strength, still features Alvin Kamara’s versatility if healthy and a young quarterback in Spencer Rattler who has shown he can make smart decisions when not overwhelmed by pressure. Expect the Seahawks to dial up different looks to confuse Rattler and force him into mistakes, particularly with the noise at Lumen Field amplifying every challenge for a rookie signal-caller on the road. Another area in which Seattle has excelled is red-zone efficiency, as both the offense and defense have been strong in converting or preventing touchdowns, a key detail in what could be a closer game than the records suggest. The Seahawks’ special teams have also been reliable, with Jason Myers providing consistency in the kicking game and the coverage units limiting big returns, further enhancing their ability to win the field-position battle. Seattle will also lean on its recent history of dominating at home early in the season, where the combination of crowd intensity and organizational preparation often gives them a decisive advantage. While the Saints have had their number in recent meetings, this year’s matchup tilts in Seattle’s favor given the Saints’ injuries and offensive uncertainty. If Smith continues his poised play and the defense keeps up its opportunistic pressure, the Seahawks should have enough firepower and discipline to maintain their unbeaten start and reinforce themselves as a team to watch in the NFC.

New Orleans vs Seattle Prop Picks (AI)

AI algorithm Remi is pouring through tons of data on each team. In fact, anytime the Saints and Seahawks play there’s always several intriguing trends to key in on. Not to mention games played at Lumen Field in Sep rarely follow normal, predictable betting trends.

Remi's searched hard and found the best prop for this matchup: A. Kamara over 52.5 Rushing Yards.

New Orleans vs Seattle Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every angle between the Saints and Seahawks and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.

Remi has been most watching on the growing weight emotional bettors often put on New Orleans’s strength factors between a Saints team going up against a possibly rested Seahawks team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line specifically.

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Below is our current AI New Orleans vs Seattle picks, computer picks Saints vs Seahawks, best bets, model edges, confidence ratings.

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New Orleans Betting Trends

New Orleans has struggled to cover early this season, particularly in games where the offense couldn’t finish drives or kept turning the ball over. Their 0-2 start has been marked by close losses and missed opportunities, like failing on a key fourth-and-2 late against San Francisco.

Seattle Betting Trends

The Seahawks, meanwhile, have been better trusted by bettors at home when their defense sets the tone early. Coming off of a 31-17 win in Week 2 over the Steelers, their home crowd and familiarity with Lumen Field could help them stay composed and cover as favorites.

Saints vs. Seahawks Matchup Trends

In the Saints-Seahawks series, despite Seattle holding the overall series lead, New Orleans has won the last four matchups. Many of those wins came by close margins, and recent betting lines show Seattle as favorites by about a touchdown, indicating bettors expect them to win, but perhaps not dominate. Also relevant: Seattle is favored by 7, and the projected total around 41.5 suggests this game might stay tight, with defenses likely to play a big role.

New Orleans vs. Seattle Game Info

September 21, 2025 • 4:05 PM EST • Lumen Field

New Orleans vs. Seattle Odds

AI algorithm Remi is pouring through tons of data points on each player. In fact, anytime the New Orleans vs Seattle trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance rarely follow normal, predictable betting trends.

New Orleans vs Seattle

New Orleans vs Seattle Live Odds

Games PTS ML SPR O/U
Dec 11, 2025 8:15PM EST
Atlanta Falcons
Tampa Bay Buccaneers
12/11/25 8:15PM
Falcons
Buccaneers
+195
-265
+5 (-110)
-5 (-114)
O 44 (-117)
U 44 (-109)
Dec 14, 2025 1:00PM EST
New York Jets
Jacksonville Jaguars
12/14/25 1PM
Jets
Jaguars
+550
-910
+13 (-115)
-13 (-110)
O 41.5 (-112)
U 41.5 (-114)
Dec 14, 2025 1:00PM EST
Baltimore Ravens
Cincinnati Bengals
12/14/25 1PM
Ravens
Bengals
-157
+123
-2.5 (-118)
+2.5 (-107)
O 51.5 (-113)
U 51.5 (-113)
Dec 14, 2025 1:00PM EST
Washington Commanders
New York Giants
12/14/25 1PM
Commanders
Giants
+110
-139
+2 (-112)
-2 (-114)
O 46.5 (-113)
U 46.5 (-112)
Dec 14, 2025 1:00PM EST
Las Vegas Raiders
Philadelphia Eagles
12/14/25 1PM
Raiders
Eagles
+550
-1000
+11.5 (-113)
-11.5 (-113)
O 38 (-112)
U 38 (-114)
Dec 14, 2025 1:00PM EST
Cleveland Browns
Chicago Bears
12/14/25 1PM
Browns
Bears
+310
-435
+7.5 (-112)
-7.5 (-114)
O 39 (-110)
U 39 (-115)
Dec 14, 2025 1:00PM EST
Arizona Cardinals
Houston Texans
12/14/25 1PM
Cardinals
Texans
+380
-560
+9.5 (-112)
-9.5 (-114)
O 42.5 (-113)
U 42.5 (-112)
Dec 14, 2025 1:00PM EST
Buffalo Bills
New England Patriots
12/14/25 1PM
Bills
Patriots
-124
-104
-1.5 (-110)
+1.5 (-115)
O 49.5 (-115)
U 49.5 (-110)
Dec 14, 2025 1:00PM EST
Los Angeles Chargers
Kansas City Chiefs
12/14/25 1PM
Chargers
Chiefs
+190
-250
+5.5 (-110)
-5.5 (-115)
O 41.5 (-114)
U 41.5 (-112)
Dec 14, 2025 4:25PM EST
Green Bay Packers
Denver Broncos
12/14/25 4:25PM
Packers
Broncos
-136
+107
-2.5 (-110)
+2.5 (-115)
O 43 (-109)
U 43 (-117)
Dec 14, 2025 4:25PM EST
Tennessee Titans
San Francisco 49ers
12/14/25 4:25PM
Titans
49ers
+650
-1250
+13 (-115)
-13 (-110)
O 44.5 (-112)
U 44.5 (-114)
Dec 14, 2025 4:25PM EST
Detroit Lions
Los Angeles Rams
12/14/25 4:25PM
Lions
Rams
+205
-275
+5.5 (-109)
-5.5 (-117)
O 55 (-117)
U 55 (-109)
Dec 14, 2025 4:25PM EST
Carolina Panthers
New Orleans Saints
12/14/25 4:25PM
Panthers
Saints
-143
+112
-2.5 (-118)
+2.5 (-108)
O 40.5 (-114)
U 40.5 (-112)
Dec 14, 2025 4:25PM EST
Indianapolis Colts
Seattle Seahawks
12/14/25 4:25PM
Colts
Seahawks
+650
-1250
+14 (-115)
-14 (-110)
O 43 (-110)
U 43 (-115)
Dec 14, 2025 8:20PM EST
Minnesota Vikings
Dallas Cowboys
12/14/25 8:20PM
Vikings
Cowboys
+235
-315
+6 (-109)
-6 (-117)
O 47.5 (-110)
U 47.5 (-115)
Dec 15, 2025 8:15PM EST
Miami Dolphins
Pittsburgh Steelers
12/15/25 8:15PM
Dolphins
Steelers
+155
-205
+3.5 (-112)
-3.5 (-113)
O 41.5 (-112)
U 41.5 (-114)
Dec 18, 2025 8:15PM EST
Los Angeles Rams
Seattle Seahawks
12/18/25 8:15PM
Rams
Seahawks
-115
-109
-1 (-109)
+1 (-117)
O 46 (-113)
U 46 (-113)
Dec 20, 2025 5:00PM EST
Philadelphia Eagles
Washington Commanders
12/20/25 5PM
Eagles
Commanders
-250
+195
-5 (-114)
+5 (-112)
O 45 (-117)
U 45 (-109)
Dec 20, 2025 8:20PM EST
Green Bay Packers
Chicago Bears
12/20/25 8:20PM
Packers
Bears
-190
+143
-3.5 (-113)
+3.5 (-113)
O 46.5 (-112)
U 46.5 (-114)
Dec 21, 2025 1:00PM EST
Kansas City Chiefs
Tennessee Titans
12/21/25 1PM
Chiefs
Titans
-770
+460
-11.5 (-113)
+11.5 (-113)
O 41.5 (-113)
U 41.5 (-113)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers New Orleans Saints vs. Seattle Seahawks on September 21, 2025 at Lumen Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

LEAN %WIN UNITS RESULT
DEN@LV RJ HARVEY ANYTIME TD 55.1% 5 WIN
HOU@KC CJ STROUD UNDER 33.5 PASS ATT 55.5% 5 WIN
WAS@MIN JAYDEN DANIELS OVER 249.5 PASS + RUSH YDS 56.4% 6 LOSS
IND@JAC IND -1 53.5% 3 LOSS
SEA@ATL ATL +7 56.6% 6 LOSS
MIA@NYJ MIA -2 53.9% 3 WIN
DEN@LV LV +8.5 57.1% 6 WIN
WAS@MIN WAS -1 55.6% 5 LOSS
SEA@ATL UNDER 44.5 56.5% 6 LOSS
DAL@DET JARED GOFF OVER 21.5 PASS COMP 54.3% 4 WIN
MIN@SEA KENNETH WALKER UNDER 80.5 RUSH + REC YDS 55.1% 5 WIN
ATL@NYJ KIRK COUSINS UNDER 194.5 PASS YDS 55.2% 5 LOSS
BUF@PIT JAYLEN WARREN OVER 60.5 RUSH YDS 54.5% 4 LOSS
DEN@WAS DEN -6.5 53.9% 3 LOSS
ATL@NYJ NYJ +3 56.9% 6 WIN
MIN@SEA SEA -11.5 54.5% 4 WIN
BUF@PIT PIT +3.5 56.9% 6 LOSS
HOU@IND IND -3 57.9% 7 LOSS
LAR@CAR OVER 44.5 54.4% 4 WIN
CHI@PHI CALEB WILLIAMS OVER 18.5 PASS COMP 55.7% 5 LOSS
KC@DAL DAL +3.5 56.3% 6 WIN
GB@DET JORDAN LOVE OVER 1.5 PASS TDS 55.6% 5 WIN
CIN@BAL LAMAR JACKSON OVER 24.5 RUSH YDS 56.7% 6 WIN
CAR@SF UNDER 49.5 53.0% 1 WIN
CAR@SF SF -7 54.0% 3 WIN
CAR@SF BRYCE YOUNG OVER 61.7 PASS COMP PCT 55.7% 5 WIN
NYJ@BAL DERRICK HENRY OVER 17.5 CARRIES 53.7% 3 WIN
JAC@ARI ARI +2.5 55.2% 5 LOSS
PHI@DAL DAL +3 53.3% 2 WIN
SEA@TEN SEA -12 57.1% 7 LOSS
MIN@GB GB -6 54.1% 3 WIN
IND@KC IND +3.5 54.6% 4 WIN
TB@LAR UNDER 49.5 52.4% 1 WIN
IND@KC UNDER 50.5 53.1% 2 WIN
NYJ@BAL BREECE HALL OVER 18.5 RECV YDS 56.7% 6 WIN
PHI@DAL JAKE ELLIOT OVER 2.5 EXTRA POINTS MADE 55.2% 5 WIN
BUF@HOU JAMES COOK UNDER 17.5 RUSH ATT 54.4% 4 WIN
BUF@HOU JOSH ALLEN UNDER 63.3 PASS COMP PCT 56.8% 6 LOSS
DAL@LV UNDER 49.5 54.3% 3 WIN
DAL@LV BROCK BOWERS OVER 6.5 RECEPTIONS 57.6% 7 WIN
CAR@ATL BRYCE YOUNG UNDER 0.5 INT 56.1% 6 WIN
KC@DEN PATRICK MAHOMES UNDER 266.5 PASS YDS 55.3% 5 LOSS
SF@ARI SF -3 56.4% 6 WIN
GB@NYG GB -7 54.3% 4 PUSH
LAC@JAC LAC -3 53.2% 3 LOSS
SEA@LAR SEA +3.5 57.2% 7 WIN
CHI@MIN MIN -2.5 53.4% 2 LOSS
DET@PHI DET +3 55.8% 5 LOSS
KC@DEN DEN +4.5 53.0% 2 WIN
DET@PHI UNDER 47 53.4% 2 WIN
SEA@LAR OVER 48.5 54.6% 4 LOSS