Saints vs. Seahawks
Prediction, Odds & Props
Sep 21 | NFL AI Picks

Updated: 2025-09-14T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The New Orleans Saints (0-2) hit the road to take on the Seattle Seahawks (1-1) in Week 3 in what has become a crucial test early in the season. Seattle comes in as about a 7-point favorite, and the over/under is set around 41.5 points, suggesting that bookies expect a moderately low-scoring affair.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 21, 2025

Start Time: 4:05 PM EST​

Venue: Lumen Field​

Seahawks Record: (1-1)

Saints Record: (0-2)

OPENING ODDS

NO Moneyline: +308

SEA Moneyline: -391

NO Spread: +7.5

SEA Spread: -7.5

Over/Under: 41.5

NO
Betting Trends

  • New Orleans has struggled to cover early this season, particularly in games where the offense couldn’t finish drives or kept turning the ball over. Their 0-2 start has been marked by close losses and missed opportunities, like failing on a key fourth-and-2 late against San Francisco.

SEA
Betting Trends

  • The Seahawks, meanwhile, have been better trusted by bettors at home when their defense sets the tone early. Coming off of a 31-17 win in Week 2 over the Steelers, their home crowd and familiarity with Lumen Field could help them stay composed and cover as favorites.

MATCHUP TRENDS

  • In the Saints-Seahawks series, despite Seattle holding the overall series lead, New Orleans has won the last four matchups. Many of those wins came by close margins, and recent betting lines show Seattle as favorites by about a touchdown, indicating bettors expect them to win, but perhaps not dominate. Also relevant: Seattle is favored by 7, and the projected total around 41.5 suggests this game might stay tight, with defenses likely to play a big role.

NO vs. SEA
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: A. Kamara over 52.5 Rushing Yards.

LIVE NFL ODDS

NFL ODDS COMPARISON

WANT MORE AI PICKS?

VAULT
VS. SPREAD
312-232
VAULT
NET UNITS
(INCL VIG)
+373.6
VAULT
NET PROFIT
(INCL VIG)
$100/UNIT
$37,360
EXECUTIVE
VS. SPREAD
1578-1345
EXECUTIVE
NET UNITS
(INCL VIG)
+397.7
EXECUTIVE
NET PROFIT
(INCL VIG)
$100/UNIT
$39,769

AI SPORTS PICK PRODUCTS

Create a Free Account

‘Create an Account’ to Get Remi’s Picks Today.

Remi Finds New Picks

Remi calculates the probability a team will cover the line.

Remi Works 24/7

Remi uses this probability to assign units to each pick.

Get Remi's AI Picks

Get Remi’s Top AI Sports Picks sent direct to your inbox.

New Orleans vs Seattle Prediction & Odds:
Free NFL Betting Insights for 9/21/25

The Week 3 matchup between the New Orleans Saints and the Seattle Seahawks on September 21, 2025, at Lumen Field carries significant intrigue as both teams look to solidify their early season identities, with Seattle entering at 1-1 after an impressive Week 2 win and New Orleans searching for its first victory at 0-2. The Saints have shown flashes of competitiveness but have been plagued by missed opportunities and inconsistent execution, as evidenced by their inability to score late against the 49ers despite racking up over 300 total yards; their rookie quarterback Spencer Rattler has been composed and turnover-averse, but injuries to playmakers such as Alvin Kamara and Chris Olave have left the offense shorthanded and forced the coaching staff to lean more heavily on depth players who have yet to find consistency. Their defense has performed admirably in stretches, especially against the run, but has struggled with discipline and situational stops late in games, and against a balanced Seahawks offense that thrives on time-of-possession dominance and strong red-zone efficiency, that could be problematic. Seattle, meanwhile, comes off a 31-17 win over Pittsburgh where their defense forced multiple three-and-outs and the offense looked balanced with Kenneth Walker III pounding the run game and Geno Smith connecting with DK Metcalf and Tyler Lockett to keep chains moving; the Seahawks are also historically tough at home, with the energy at Lumen Field often giving them a mental edge that translates to a physical one in contested games.

While the Seahawks are favored by about a touchdown and the projected point total of 41.5 suggests a lower-scoring tilt, the Saints’ recent history of beating Seattle in four straight meetings could provide some confidence, though most of those came with healthier rosters and steadier execution than what New Orleans currently brings. Key matchups to watch include the Saints’ offensive line, which must protect Rattler against a Seahawks pass rush that thrives on noise and speed, as well as New Orleans’ secondary against Seattle’s receiving duo, with one or two explosive plays likely to swing momentum. Turnover margin, which has hurt New Orleans so far, could be decisive, and the Saints will need to force at least one defensive takeaway to have a chance. Overall, this game shapes up as a battle between Seattle’s proven home-field edge and roster stability against New Orleans’ search for consistency and identity, and while the Seahawks seem positioned to take care of business, the Saints’ history of pushing them could keep the spread in play if they clean up mistakes and sustain drives.

New Orleans Saints NFL Preview

The New Orleans Saints enter this matchup against the Seattle Seahawks with plenty to prove as they try to avoid falling into an 0-3 hole to start the 2025 season, and their focus will be on shoring up both consistency and execution after two close but disappointing losses. Led by rookie quarterback Spencer Rattler, the Saints’ offense has not been without promise, as Rattler has displayed poise in the pocket and avoided costly turnovers, but the lack of continuity at the skill positions due to injuries has held back their overall effectiveness. Alvin Kamara’s status remains in question, and his absence or limited availability greatly impacts the Saints’ ability to both run the football and use him as a versatile weapon in the passing game, leaving a heavier load on Rattler to connect with a receiving corps missing Chris Olave and relying on secondary options to create separation. That puts extra pressure on the offensive line, which has struggled in spots against pressure-heavy defenses, and Seattle’s ability to generate pass rush at home in front of a loud crowd could create the type of disruption that derails drives and forces quick punts. Defensively, New Orleans has been competitive, with the front seven limiting rushing lanes and keeping opposing ground games from dominating, but they have struggled with situational stops, particularly on third downs and in the red zone, which has led to extended drives and late-game breakdowns.

Facing Geno Smith, DK Metcalf, and Tyler Lockett will test the Saints’ secondary, which has been inconsistent in coverage and vulnerable to giving up chunk plays through the air. For New Orleans to stay competitive, the key lies in creating takeaways, an area where they have fallen short early in the season, and flipping the field to give their offense shorter scoring opportunities. If the Saints’ defense can generate turnovers and their offensive line can hold up enough for Rattler to find rhythm with his receivers, New Orleans has the potential to make this a competitive game. Their recent history of success against the Seahawks, including four straight victories in past meetings, provides some confidence despite the underdog status, but this version of the team is younger, banged up, and still finding its footing. To pull off the upset, the Saints will need near-flawless execution, limit penalties that have stalled drives, and find a way to establish a running game to balance their offense and keep Seattle’s defense honest. While the odds and environment are stacked against them, New Orleans has shown flashes of resilience, and if Rattler continues his growth trajectory, the Saints may have enough to at least keep the spread close and give themselves a shot at their first win of the season.

The New Orleans Saints (0-2) hit the road to take on the Seattle Seahawks (1-1) in Week 3 in what has become a crucial test early in the season. Seattle comes in as about a 7-point favorite, and the over/under is set around 41.5 points, suggesting that bookies expect a moderately low-scoring affair.  New Orleans vs Seattle AI Prediction: Free NFL Betting Insights for Sep 21. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Seattle Seahawks NFL Preview

The Seattle Seahawks enter this matchup against the New Orleans Saints with confidence and momentum, having opened the season 2-0 behind a combination of efficient offense, timely defense, and the undeniable energy of playing in front of one of the NFL’s toughest home-field environments. Quarterback Geno Smith has settled into his role as a steady leader of the offense, spreading the ball effectively between DK Metcalf, Tyler Lockett, and Jaxon Smith-Njigba, while also utilizing his running backs to keep defenses off balance. The passing attack has been particularly efficient on third downs, extending drives and wearing down opposing defenses, which is a crucial element when facing a Saints unit that has been inconsistent at getting off the field in high-pressure moments. Seattle’s offensive line, often a source of questions in recent seasons, has performed better than expected in pass protection and has allowed Smith the necessary time to read defenses and take calculated shots downfield. The ground game, spearheaded by Kenneth Walker III and supported by rookie Zach Charbonnet, provides balance and has allowed the Seahawks to control tempo, a strategy that should be critical against a Saints defense that has been vulnerable to extended possessions.

Defensively, Seattle continues to thrive under Pete Carroll’s aggressive approach, with a front seven that applies steady pressure and a secondary anchored by Tariq Woolen, who has developed into one of the league’s top young corners. This group will be tested by a New Orleans offense that, while not at full strength, still features Alvin Kamara’s versatility if healthy and a young quarterback in Spencer Rattler who has shown he can make smart decisions when not overwhelmed by pressure. Expect the Seahawks to dial up different looks to confuse Rattler and force him into mistakes, particularly with the noise at Lumen Field amplifying every challenge for a rookie signal-caller on the road. Another area in which Seattle has excelled is red-zone efficiency, as both the offense and defense have been strong in converting or preventing touchdowns, a key detail in what could be a closer game than the records suggest. The Seahawks’ special teams have also been reliable, with Jason Myers providing consistency in the kicking game and the coverage units limiting big returns, further enhancing their ability to win the field-position battle. Seattle will also lean on its recent history of dominating at home early in the season, where the combination of crowd intensity and organizational preparation often gives them a decisive advantage. While the Saints have had their number in recent meetings, this year’s matchup tilts in Seattle’s favor given the Saints’ injuries and offensive uncertainty. If Smith continues his poised play and the defense keeps up its opportunistic pressure, the Seahawks should have enough firepower and discipline to maintain their unbeaten start and reinforce themselves as a team to watch in the NFC.

New Orleans vs. Seattle Prop Picks (AI)

Remi is pouring through mountains of datapoints on each line. In fact, anytime the Saints and Seahawks play there’s always several intriguing observations to key in on. Not to mention games played at Lumen Field in Sep almost always follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: A. Kamara over 52.5 Rushing Yards.

New Orleans vs. Seattle Prediction (AI)

Remi Robot Icon

Remi, our AI sports algorithm, has been pouring over mountains of data from every angle between the Saints and Seahawks and using recursive machine learning and cutting-edge AI to boil down the data to a single cover probability.

Remi has been most focused on the unproportionally assigned emphasis knucklehead sportsbettors often put on Seattle’s strength factors between a Saints team going up against a possibly rested Seahawks team. We’ve found the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI New Orleans vs Seattle picks, computer picks Saints vs Seahawks, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NFL 10/9 PHI@NYG UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Saints Betting Trends

New Orleans has struggled to cover early this season, particularly in games where the offense couldn’t finish drives or kept turning the ball over. Their 0-2 start has been marked by close losses and missed opportunities, like failing on a key fourth-and-2 late against San Francisco.

Seahawks Betting Trends

The Seahawks, meanwhile, have been better trusted by bettors at home when their defense sets the tone early. Coming off of a 31-17 win in Week 2 over the Steelers, their home crowd and familiarity with Lumen Field could help them stay composed and cover as favorites.

Saints vs. Seahawks Matchup Trends

In the Saints-Seahawks series, despite Seattle holding the overall series lead, New Orleans has won the last four matchups. Many of those wins came by close margins, and recent betting lines show Seattle as favorites by about a touchdown, indicating bettors expect them to win, but perhaps not dominate. Also relevant: Seattle is favored by 7, and the projected total around 41.5 suggests this game might stay tight, with defenses likely to play a big role.

New Orleans vs. Seattle Game Info

New Orleans vs Seattle starts on September 21, 2025 at 4:05 PM EST.

Spread: Seattle -7.5
Moneyline: New Orleans +308, Seattle -391
Over/Under: 41.5

New Orleans: (0-2)  |  Seattle: (1-1)

Remi's searched hard and found the best prop for this matchup: A. Kamara over 52.5 Rushing Yards.. Prices move—always shop for the best number.

In the Saints-Seahawks series, despite Seattle holding the overall series lead, New Orleans has won the last four matchups. Many of those wins came by close margins, and recent betting lines show Seattle as favorites by about a touchdown, indicating bettors expect them to win, but perhaps not dominate. Also relevant: Seattle is favored by 7, and the projected total around 41.5 suggests this game might stay tight, with defenses likely to play a big role.

NO trend: New Orleans has struggled to cover early this season, particularly in games where the offense couldn’t finish drives or kept turning the ball over. Their 0-2 start has been marked by close losses and missed opportunities, like failing on a key fourth-and-2 late against San Francisco.

SEA trend: The Seahawks, meanwhile, have been better trusted by bettors at home when their defense sets the tone early. Coming off of a 31-17 win in Week 2 over the Steelers, their home crowd and familiarity with Lumen Field could help them stay composed and cover as favorites.

See our latest NFL picks and odds pages for 2025 to compare prices before you bet.

New Orleans vs. Seattle Odds

Remi is pouring through mountains of stats on each player. In fact, anytime the New Orleans vs Seattle trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable patterns.

New Orleans vs Seattle Opening Odds

NO Moneyline: +308
SEA Moneyline: -391
NO Spread: +7.5
SEA Spread: -7.5
Over/Under: 41.5

New Orleans vs Seattle Live Odds

Games PTS ML SPR O/U
Oct 9, 2025 8:15PM EDT
Philadelphia Eagles
New York Giants
10/9/25 8:15PM
Eagles
Giants
-420
+305
-7.5 (-105)
+7.5 (-115)
O 40.5 (-115)
U 40.5 (-105)
Oct 12, 2025 9:30AM EDT
Denver Broncos
New York Jets
10/12/25 9:30AM
Broncos
Jets
-400
+300
-7 (-111)
+7 (-111)
O 43.5 (-105)
U 43.5 (-115)
Oct 12, 2025 1:00PM EDT
Seattle Seahawks
Jacksonville Jaguars
10/12/25 1PM
Seahawks
Jaguars
-108
-112
-1 (+100)
+1 (-125)
O 47.5 (-107)
U 47.5 (-114)
Oct 12, 2025 1:00PM EDT
New England Patriots
New Orleans Saints
10/12/25 1PM
Patriots
Saints
-193
+155
-3.5 (+100)
+3.5 (-121)
O 45.5 (-115)
U 45.5 (-106)
Oct 12, 2025 1:01PM EDT
Cleveland Browns
Pittsburgh Steelers
10/12/25 1:01PM
Browns
Steelers
+215
-275
+5.5 (+100)
-5.5 (-121)
O 38.5 (-109)
U 38.5 (-112)
Oct 12, 2025 1:01PM EDT
Los Angeles Chargers
Miami Dolphins
10/12/25 1:01PM
Chargers
Dolphins
-213
+170
-4 (-109)
+4 (-112)
O 43.5 (-121)
U 43.5 (+100)
Oct 12, 2025 1:01PM EDT
Los Angeles Rams
Baltimore Ravens
10/12/25 1:01PM
Rams
Ravens
-400
+305
-7.5 (-108)
+7.5 (-113)
O 44.5 (-113)
U 44.5 (-108)
Oct 12, 2025 1:01PM EDT
Dallas Cowboys
Carolina Panthers
10/12/25 1:01PM
Cowboys
Panthers
-176
+140
-3 (-109)
+3 (-112)
O 49.5 (-112)
U 49.5 (-109)
Oct 12, 2025 1:01PM EDT
Arizona Cardinals
Indianapolis Colts
10/12/25 1:01PM
Cardinals
Colts
+275
-360
+7.5 (-111)
-7.5 (-110)
O 46.5 (-113)
U 46.5 (-108)
Oct 12, 2025 4:06PM EDT
Tennessee Titans
Las Vegas Raiders
10/12/25 4:06PM
Titans
Raiders
+185
-235
+4.5 (-117)
-4.5 (-105)
O 41.5 (-112)
U 41.5 (-109)
Oct 12, 2025 4:26PM EDT
Cincinnati Bengals
Green Bay Packers
10/12/25 4:26PM
Bengals
Packers
+700
-1250
+14 (-107)
-14 (-113)
O 44.5 (-109)
U 44.5 (-112)
Oct 12, 2025 4:26PM EDT
San Francisco 49ers
Tampa Bay Buccaneers
10/12/25 4:26PM
49ers
Buccaneers
+135
-164
+3 (-108)
-3 (-113)
O 47.5 (-110)
U 47.5 (-110)
Oct 12, 2025 8:20PM EDT
Detroit Lions
Kansas City Chiefs
10/12/25 8:20PM
Lions
Chiefs
+115
-135
+2 (-110)
-2 (-110)
O 53 (-110)
U 53 (-110)
Oct 13, 2025 7:15PM EDT
Buffalo Bills
Atlanta Falcons
10/13/25 7:15PM
Bills
Falcons
-230
+180
-4.5 (-110)
+4.5 (-110)
O 49.5 (-114)
U 49.5 (-106)
Oct 13, 2025 8:16PM EDT
Chicago Bears
Washington Commanders
10/13/25 8:16PM
Bears
Commanders
+185
-230
+4.5 (-110)
-4.5 (-109)
O 50 (-108)
U 50 (-113)
Oct 16, 2025 8:16PM EDT
Pittsburgh Steelers
Cincinnati Bengals
10/16/25 8:16PM
Steelers
Bengals
-240
+185
-4 (-110)
+4 (-110)
O 43 (-110)
U 43 (-110)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers New Orleans Saints vs. Seattle Seahawks on September 21, 2025 at Lumen Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
HOU@BAL HOU -125 58.5% 7 WIN
DET@CIN DET -10 55.6% 5 WIN
DAL@NYJ NYJ +1.5 53.7% 3 LOSS
TB@SEA TB +3.5 54.9% 4 WIN
TEN@ARI ARI -7 (BUY 0.5) 54.9% 4 LOSS
DEN@PHI DEN +4.5 57.5% 7 WIN
MIA@CAR TETAIROA MCMILLAN OVER 58.5 RECV YDS 54.5% 4 WIN
LV@IND ASHTON JEANTY UNDER 67.5 RUSH YDS 54.4% 4 WIN
SF@LAR DEMARCUS ROBINSON OVER 29.5 RECV YDS 55.7% 5 WIN
NYJ@MIA NYJ +3 53.8 3 LOSS
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS
TEN@HOU TEN +7.5 57.9% 7 LOSS
LAC@NYG LAC -6 57.3% 7 LOSS
NO@BUF UNDER 48.5 55.1% 3 LOSS
GB@DAL JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS 55.5% 5 LOSS
CAR@NE DRAKE MAYE TO THROW AN INT 56.6% 6 LOSS
SEA@ARI SEA -125 57.7% 6 WIN
SEA@ARI KYLER MURRAY TO THROW AN INT 56.6% 6 WIN
DET@BAL JAHMYR GIBBS OVER 0.5 RUSH TDS 55.8% 5 WIN
DAL@CHI DAL -120 58.7% 6 LOSS
PIT@NE PIT -116 60.1% 6 WIN
ATL@CAR ATL -4.5 55.4% 5 LOSS
LV@WAS LV +3 54.3% 4 LOSS
GB@CLE GB -7 54.3% 4 LOSS
ARI@SF ARI +3 57.7% 6 WIN
KC@NYG PATRICK MAHOMES OVER 230.5 PASS YDS 54.7% 4 WIN
GB@CLE JOE FLACCO OVER 37.5 PASS ATT 56.6% 6 LOSS
MIA@BUF TYREEK HILL OVER 5.5 TOTAL RECEPTIONS 56.8% 6 LOSS
LAC@LV LAC -3 54.9% 4 WIN
TB@HOU BAKER MAYFIELD OVER 1.5 PASS TDS 54.4% 4 WIN
CHI@DET DET -6.5 54.3% 4 WIN
DEN@IND DEN -118 60.1% 10 LOSS
PHI@KC PHI -115 56.7% 6 WIN
SF@NO SF -3 58.8% 8 WIN
SEA@PIT OVER 40 54.9% 4 WIN
CAR@ARI BRYCE YOUNG INTERCEPTIONS UNDER 0.5 56.4% 6 LOSS
DEN@IND JOSH DOWNS RECEPTIONS OVER 3.5 54.7% 4 WIN
ATL@MIN BIJAN ROBINSON RUSH + REC YDS OVER 94.5 53.4% 3 WIN
WAS@GB WAS +3.5 56.5% 6 LOSS
WAS@GB JORDAN LOVE OVER 5.5 RUSH YDS 54.7% 4 WIN
MIN@CHI CALEB WILLIAMS OVER 219.5 PASS YDS 53.4% 3 LOSS
TEN@DEN DEN -8.5 55.3% 5 LOSS
SF@SEA SF -115 54.6% 4 WIN
SF@SEA KENNETH WALKER III UNDER 79.5 RUSH+REC YDS 54.6% 4 WIN
CAR@JAC TANK BIGSBY OVER 10.5 RUSH ATT 56.1% 6 LOSS