Dolphins vs Bills Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 18)

Updated: 2025-09-11T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Buffalo Bills (2-0) host the Miami Dolphins (0-2) on September 18, 2025, at Highmark Stadium in what looms as a must-win AFC East clash for Miami and a chance for Buffalo to further assert their early dominance in the division. With Josh Allen trending upward and Miami sputtering under pressure both offensively and defensively, the Bills are heavily favored, as oddsmakers open Buffalo around -12.5 and set the over/under near 49.5 points.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 18, 2025

Start Time: 8:15 PM EST​

Venue: Highmark Stadium​

Bills Record: (2-0)

Dolphins Record: (0-2)

OPENING ODDS

MIA Moneyline: +566

BUF Moneyline: -826

MIA Spread: +11.5

BUF Spread: -11.5

Over/Under: 49.5

MIA
Betting Trends

  • Miami has struggled against the spread this early season, with sportsbooks largely fading them as underdogs in their losses to the Colts and Patriots; the lack of offensive consistency, especially from Tua Tagovailoa and his supporting cast, has made them a risky play.

BUF
Betting Trends

  • Buffalo has shown more reliability ATS at home, especially in divisional games, where their defensive strength and ability to control tempo often help them cover large spreads; bettors have noticed Buffalo’s ability to dominate rivals in these setups.

MATCHUP TRENDS

  • With the line at Buffalo -12.5 and the total around 49.5, value is seen in backing the Bills to both win convincingly and potentially push toward the over, assuming Miami’s defense gives up big plays. Also of note: Miami has lost their last six matchups with Buffalo, and hasn’t won in Buffalo since 2016, trends that often influence public betting.

MIA vs. BUF
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: R. Davis under 23.5 Rushing Yards.

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Miami vs Buffalo Prediction & Odds:
Free NFL Betting Insights for 9/18/25

The matchup between the Miami Dolphins and the Buffalo Bills on September 18, 2025, is not just another AFC East clash but a critical litmus test for both teams’ trajectories, with Buffalo entering 2-0 and looking like a polished contender, while Miami sits at 0-2, desperate to avoid a third straight loss that could cripple their playoff aspirations before October arrives. Buffalo’s offense has been revitalized by its ground game, with James Cook emerging as a star after shredding the Jets’ defense for 132 yards and two touchdowns, giving the Bills a reliable complement to Josh Allen’s arm and mobility, and Allen himself continues to be the heartbeat of the team, a dual-threat quarterback whose command of the offense, even after sustaining a bloody nose in Week 2, demonstrates both toughness and leadership. The receiving corps led by Stefon Diggs, Gabe Davis, and Dalton Kincaid stretches defenses horizontally and vertically, and when paired with an offensive line that has done a better job of keeping Allen upright, the Bills have shown they can control tempo and dominate games on their terms. Their defense, always a strength under Sean McDermott, has been opportunistic, pressuring quarterbacks into mistakes and keeping points off the board, with a disciplined front seven and a secondary that, while occasionally beatable, still ranks among the more physical units in the AFC. Miami, meanwhile, enters this game in search of answers, as Tua Tagovailoa has struggled with turnovers and inconsistency, and though he has weapons in Tyreek Hill and Jaylen Waddle, the offense has sputtered due to poor protection, lack of rhythm, and failure to finish drives, leaving their defense overexposed.

The Dolphins’ defense has been particularly porous against the run and in explosive-play prevention, two glaring weaknesses that Buffalo is equipped to exploit, and without significant improvement in generating pressure on Allen, Miami risks being picked apart all afternoon. Special teams and penalties will also play a role, as Buffalo has thrived in field position battles while Miami has hurt itself with costly mistakes, making discipline and execution even more crucial in what is expected to be a hostile environment at Highmark Stadium. The betting market reflects this disparity, with Buffalo opening as heavy favorites at -12.5, and with the over/under near 49.5, oddsmakers anticipate scoring but lean on Buffalo’s ability to put up points while questioning Miami’s capacity to keep pace, a trend supported by Miami’s six straight losses to the Bills and a near decade-long drought in Buffalo. For Miami to cover or pull off an upset, they must play mistake-free football, sustain drives with balance between run and pass, and hope their defense forces turnovers that tilt momentum; otherwise, Buffalo’s depth, balance, and physical edge are likely to overwhelm. Ultimately, this game looks like a classic contrast of a contender firing on all cylinders versus a team in early crisis mode, and the outcome will likely confirm whether Buffalo is poised to dominate the AFC East again and whether Miami has the resilience to claw back into relevance after a disappointing start.

Miami Dolphins NFL Preview

The Miami Dolphins step into their Week 3 clash with the Buffalo Bills carrying the heavy burden of an 0-2 start, and the pressure to avoid another divisional loss looms large for a team that entered the year with playoff expectations but has yet to find its offensive identity. Quarterback Tua Tagovailoa has endured a rocky start, struggling with turnovers, forced throws, and inconsistent timing with his star wideouts Tyreek Hill and Jaylen Waddle, which has stalled the offense and placed added pressure on a running game that has yet to establish rhythm. Miami’s offensive line has been a significant issue, giving up too much pressure and limiting Tua’s ability to make quick, decisive reads, while the lack of consistent push in the run game has made them predictable against defenses that are already scheming to contain Hill’s speed and Waddle’s versatility. Mike McDaniel’s system thrives on pace, motion, and rhythm, but through two games the Dolphins have looked disjointed, with drives sputtering due to negative plays, penalties, and missed opportunities in the red zone. On the defensive side, Miami has not been able to replicate the pressure or opportunistic turnovers that defined some of their better stretches in past seasons, and their secondary has been exposed, particularly against vertical passing attacks that exploit mismatches when the pass rush fails to get home.

The run defense has also been leaky, a critical weakness heading into a matchup against a Bills team that just gashed the Jets for over 200 yards on the ground and will look to test Miami’s ability to hold the line of scrimmage. Special teams have not provided much relief either, as field position battles have tilted against them, compounding the struggles of both offense and defense. For Miami to compete in this game, they will need to execute nearly flawlessly: Tua must protect the ball, Hill and Waddle must win their one-on-one matchups, and the offensive line must at least hold steady enough to prevent Buffalo from overwhelming them with pressure. Defensively, they will need to commit to limiting James Cook’s impact in the run game, contain Josh Allen’s scrambling ability, and avoid giving up backbreaking big plays through the air. Betting trends don’t favor Miami, as they have lost six straight to Buffalo and haven’t won in Orchard Park since 2016, but divisional games often produce surprises, and their only path to covering or winning outright likely comes from forcing turnovers, capitalizing on short fields, and starting fast to keep the Bills from seizing early momentum. While the Dolphins are backed into a corner and must treat this as a must-win game, the reality is that unless they clean up execution and find a way to play complementary football across all three phases, they risk being outmatched again by a Buffalo team that looks more complete, disciplined, and prepared at this stage of the season.

The Buffalo Bills (2-0) host the Miami Dolphins (0-2) on September 18, 2025, at Highmark Stadium in what looms as a must-win AFC East clash for Miami and a chance for Buffalo to further assert their early dominance in the division. With Josh Allen trending upward and Miami sputtering under pressure both offensively and defensively, the Bills are heavily favored, as oddsmakers open Buffalo around -12.5 and set the over/under near 49.5 points. Miami vs Buffalo AI Prediction: Free NFL Betting Insights for Sep 18. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Buffalo Bills NFL Preview

The Buffalo Bills enter their Week 3 showdown with the Miami Dolphins brimming with confidence after opening the season 2-0 and showing signs of being one of the most balanced teams in the AFC, blending offensive firepower with a defense capable of dictating tempo and frustrating opposing quarterbacks. Josh Allen remains the focal point of Buffalo’s attack, and while his playmaking has always been defined by explosive throws and improvisation, this season he has benefitted from a more reliable supporting cast and a stronger run game, which has allowed him to pick his spots rather than shoulder the entire burden. James Cook’s emergence as a feature back has been a game-changer, as his ability to not only churn out yards on the ground but also contribute as a receiver out of the backfield adds a new dimension to the offense, while Stefon Diggs continues to be Allen’s most trusted target, delivering in clutch moments and stretching defenses deep. Gabe Davis and Dalton Kincaid provide valuable complementary options, ensuring defenses can’t simply key in on Diggs, and together this group has made Buffalo’s offense one of the most versatile in the league. On the defensive side, Sean McDermott’s unit has been as disciplined as it is aggressive, with the front seven excelling at creating pressure and bottling up run games, forcing opponents into predictable passing situations where the secondary can capitalize.

Even with a few injuries to monitor, the Bills’ depth and communication on defense have limited opponents to minimal yards after the catch and produced turnovers in pivotal moments, giving their offense favorable field position. Special teams, often overlooked, have also been sharp, with solid coverage and reliable kicking that reinforces Buffalo’s ability to control field position. Playing at Highmark Stadium adds another layer of advantage, as the home crowd creates one of the most hostile environments in the NFL, where noise disrupts opposing offenses and energizes Buffalo’s defense. Against Miami, Buffalo’s game plan will likely center on establishing the run early, using Cook and Allen’s legs to control tempo, then striking with explosive passing plays once Miami’s defense is forced to adjust. Defensively, they will aim to collapse the pocket quickly and disrupt Tua Tagovailoa’s timing with Tyreek Hill and Jaylen Waddle, while also ensuring they limit yards after the catch by rallying to the ball. From a betting standpoint, the Bills have been reliable at home when favored by double digits, as their ability to pile on points and tighten defensively late makes them a strong covering team in these spots, particularly against divisional opponents that have struggled in recent years. For Buffalo, this matchup is about maintaining momentum, continuing to refine their balanced identity, and sending a clear message to the rest of the division that the road to the AFC East crown still runs through them, and if they execute at the level they have through the first two weeks, they are well positioned to extend their dominance over a Miami team still searching for answers.

Miami vs. Buffalo Prop Picks (AI)

Remi is pouring through loads of data on each team. In fact, anytime the Dolphins and Bills play there’s always several intriguing trends to key in on. Not to mention games played at Highmark Stadium in Sep rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: R. Davis under 23.5 Rushing Yards.

Miami vs. Buffalo Prediction (AI)

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Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every facet between the Dolphins and Bills and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most focused on the linear correlation of factor knucklehead sportsbettors often put on coaching factors between a Dolphins team going up against a possibly strong Bills team. We’ve found the true game analytics appear to reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Miami vs Buffalo picks, computer picks Dolphins vs Bills, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Dolphins Betting Trends

Miami has struggled against the spread this early season, with sportsbooks largely fading them as underdogs in their losses to the Colts and Patriots; the lack of offensive consistency, especially from Tua Tagovailoa and his supporting cast, has made them a risky play.

Bills Betting Trends

Buffalo has shown more reliability ATS at home, especially in divisional games, where their defensive strength and ability to control tempo often help them cover large spreads; bettors have noticed Buffalo’s ability to dominate rivals in these setups.

Dolphins vs. Bills Matchup Trends

With the line at Buffalo -12.5 and the total around 49.5, value is seen in backing the Bills to both win convincingly and potentially push toward the over, assuming Miami’s defense gives up big plays. Also of note: Miami has lost their last six matchups with Buffalo, and hasn’t won in Buffalo since 2016, trends that often influence public betting.

Miami vs. Buffalo Game Info

Miami vs Buffalo starts on September 18, 2025 at 8:15 PM EST.

Venue: Highmark Stadium.

Spread: Buffalo -11.5
Moneyline: Miami +566, Buffalo -826
Over/Under: 49.5

Miami: (0-2)  |  Buffalo: (2-0)

Remi's searched hard and found the best prop for this matchup: R. Davis under 23.5 Rushing Yards.. Prices move—always shop for the best number.

With the line at Buffalo -12.5 and the total around 49.5, value is seen in backing the Bills to both win convincingly and potentially push toward the over, assuming Miami’s defense gives up big plays. Also of note: Miami has lost their last six matchups with Buffalo, and hasn’t won in Buffalo since 2016, trends that often influence public betting.

MIA trend: Miami has struggled against the spread this early season, with sportsbooks largely fading them as underdogs in their losses to the Colts and Patriots; the lack of offensive consistency, especially from Tua Tagovailoa and his supporting cast, has made them a risky play.

BUF trend: Buffalo has shown more reliability ATS at home, especially in divisional games, where their defensive strength and ability to control tempo often help them cover large spreads; bettors have noticed Buffalo’s ability to dominate rivals in these setups.

See our latest NFL picks and odds pages for 2025 to compare prices before you bet.

Miami vs. Buffalo Odds

AI algorithm Remi is pouring through loads of data points on each line. In fact, anytime the Miami vs Buffalo trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme altitude can often follow normal, predictable betting trends.

Miami vs Buffalo Opening Odds

MIA Moneyline: +566
BUF Moneyline: -826
MIA Spread: +11.5
BUF Spread: -11.5
Over/Under: 49.5

Miami vs Buffalo Live Odds

Games PTS ML SPR O/U
Oct 30, 2025 8:15PM EDT
Baltimore Ravens
Miami Dolphins
10/30/25 8:15PM
Ravens
Dolphins
-440
+344
-7.5 (-110)
+7.5 (-110)
O 51 (-105)
U 51 (-115)
Nov 2, 2025 1:00PM EST
Chicago Bears
Cincinnati Bengals
11/2/25 1PM
Bears
Bengals
-160
+140
-2.5 (-125)
+2.5 (+105)
O 51.5 (-104)
U 51.5 (-116)
Nov 2, 2025 1:00PM EST
Indianapolis Colts
Pittsburgh Steelers
11/2/25 1PM
Colts
Steelers
-171
+150
-3 (-117)
+3 (-103)
O 50.5 (-110)
U 50.5 (-110)
Nov 2, 2025 1:00PM EST
Carolina Panthers
Green Bay Packers
11/2/25 1PM
Panthers
Packers
+613
-900
+13 (-105)
-13 (-115)
O 44 (-110)
U 44 (-110)
Nov 2, 2025 1:00PM EST
Atlanta Falcons
New England Patriots
11/2/25 1PM
Falcons
Patriots
+207
-250
+5 (-105)
-5 (-115)
O 45 (-110)
U 45 (-110)
Nov 2, 2025 1:00PM EST
Denver Broncos
Houston Texans
11/2/25 1PM
Broncos
Texans
+105
-125
+1 (+100)
-1 (-120)
O 40 (-110)
U 40 (-110)
Nov 2, 2025 1:00PM EST
San Francisco 49ers
New York Giants
11/2/25 1PM
49ers
Giants
-147
+127
-2.5 (-115)
+2.5 (-105)
O 49 (-103)
U 49 (-117)
Nov 2, 2025 1:00PM EST
Los Angeles Chargers
Tennessee Titans
11/2/25 1PM
Chargers
Titans
-500
+383
-9.5 (-105)
+9.5 (-115)
O 43.5 (-108)
U 43.5 (-112)
Nov 2, 2025 1:00PM EST
Minnesota Vikings
Detroit Lions
11/2/25 1PM
Vikings
Lions
+374
-485
+9 (-110)
-9 (-110)
O 47.5 (-117)
U 47.5 (-103)
Nov 2, 2025 4:05PM EST
New Orleans Saints
Los Angeles Rams
11/2/25 4:05PM
Saints
Rams
+754
-1200
+13.5 (+100)
-13.5 (-120)
O 44 (-107)
U 44 (-113)
Nov 2, 2025 4:05PM EST
Jacksonville Jaguars
Las Vegas Raiders
11/2/25 4:05PM
Jaguars
Raiders
-150
+130
-3 (+100)
+3 (-120)
O 44.5 (-110)
U 44.5 (-110)
Nov 2, 2025 4:25PM EST
Kansas City Chiefs
Buffalo Bills
11/2/25 4:25PM
Chiefs
Bills
-130
+110
-2 (-110)
+2 (-110)
O 52.5 (-110)
U 52.5 (-110)
Nov 2, 2025 8:20PM EST
Seattle Seahawks
Washington Commanders
11/2/25 8:20PM
Seahawks
Commanders
-163
+143
-3 (-113)
+3 (-107)
O 48 (-110)
U 48 (-110)
Nov 3, 2025 8:15PM EST
Arizona Cardinals
Dallas Cowboys
11/3/25 8:15PM
Cardinals
Cowboys
+130
-150
+2.5 (-105)
-2.5 (-115)
O 53.5 (-105)
U 53.5 (-115)
Nov 6, 2025 8:15PM EST
Las Vegas Raiders
Denver Broncos
11/6/25 8:15PM
Raiders
Broncos
+370
-480
+9.5 (-106)
-9.5 (-114)
O 42.5 (-110)
U 42.5 (-110)
Nov 9, 2025 9:30AM EST
Atlanta Falcons
Indianapolis Colts
11/9/25 9:30AM
Falcons
Colts
+290
-360
+7 (-106)
-7 (-114)
O 48.5 (-110)
U 48.5 (-110)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Miami Dolphins vs. Buffalo Bills on September 18, 2025 at Highmark Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TB@NO TB -3.5 52.3% 1 WIN
GB@PIT GB -2.5 52.3% 1 WIN
SF@HOU SF +2.5 56.0% 6 LOSS
NYG@PHI NYG +7.5 53.9% 3 LOSS
BUF@CAR CAR +7.5 54.2% 3 LOSS
DAL@DEN DAL +3.5 55.0% 4 LOSS
MIA@ATL MIA +7 54.3% 4 WIN
CLE@NE CLE +7 56.8% 6 LOSS
TB@NO BAKER MAYFIELD OVER 15.5 RUSH YDS 56.6% 6 LOSS
MIN@LAC JUSTIN HERBERT PASS ATT UNDER 35.5 55.5% 5 WIN
TB@DET TB +6.5 54.4% 4 LOSS
TB@DET RACHAAD WHITE UNDER 14.5 RUSH ATT 54.4% 4 WIN
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS
HOU@BAL HOU -125 58.5% 7 WIN
DET@CIN DET -10 55.6% 5 WIN
DAL@NYJ NYJ +1.5 53.7% 3 LOSS
TB@SEA TB +3.5 54.9% 4 WIN
TEN@ARI ARI -7 (BUY 0.5) 54.9% 4 LOSS
DEN@PHI DEN +4.5 57.5% 7 WIN
MIA@CAR TETAIROA MCMILLAN OVER 58.5 RECV YDS 54.5% 4 WIN
LV@IND ASHTON JEANTY UNDER 67.5 RUSH YDS 54.4% 4 WIN
SF@LAR DEMARCUS ROBINSON OVER 29.5 RECV YDS 55.7% 5 WIN
NYJ@MIA NYJ +3 53.8 3 LOSS
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS