Broncos vs Bills Prediction — AI Finds CAN'T MISS NFL Lines & Props (Jan 12)
Updated: 2025-01-05T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Denver Broncos are set to face the Buffalo Bills in an AFC Wild Card matchup on January 12, 2025, at Highmark Stadium in Buffalo. The Bills, boasting a 13-4 record, are favored by 8.5 points, while the Broncos, entering the playoffs for the first time since their 2016 Super Bowl victory, hold a 10-7 record.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Jan 12, 2025
Start Time: 2:00 PM EST
Venue: Highmark Stadium
Bills Record: (13-4)
Broncos Record: (10-7)
OPENING ODDS
DEN Moneyline: +346
BUF Moneyline: -446
DEN Spread: +8.5
BUF Spread: -8.5
Over/Under: 47
DEN
Betting Trends
- The Broncos have demonstrated resilience against the spread (ATS) this season. Notably, they have covered the spread in four of their last five games, indicating a strong finish to the regular season. On the road, Denver has been competitive, achieving a 3-2 ATS record in their last five away games. This suggests that the Broncos have the capability to perform well, even in challenging environments.
BUF
Betting Trends
- The Bills have been formidable ATS, particularly at home. They have covered the spread in six of their last seven games at Highmark Stadium, showcasing their dominance on home turf. Overall, Buffalo holds a 5-2 ATS record in their last seven games, reflecting consistent performance against betting expectations.
MATCHUP TRENDS
- An interesting ATS statistic for this matchup is the Bills’ recent success against the Broncos. Buffalo has covered the spread in three of their last four meetings with Denver. This trend may influence betting perspectives, highlighting the Bills’ historical advantage in this pairing.
DEN vs. BUF
Best Prop Bet
- Remi's searched hard and found the perfect prop bet for this game: WR Amari Cooper Over 3.5 Targets
LIVE NFL ODDS
NFL ODDS COMPARISON
WANT MORE AI PICKS?
NET UNITS (INCL VIG)
NET PROFIT (INCL VIG) $100/UNIT
NET UNITS (INCL VIG)
NET PROFIT (INCL VIG) $100/UNIT
AI SPORTS PICK PRODUCTS
Create a Free Account
‘Create an Account’ to Get Remi’s Picks Today. Remi Finds New Picks
Remi calculates the probability a team will cover the line. Remi Works 24/7
Remi uses this probability to assign units to each pick.
Get Remi's AI Picks
Get Remi’s Top AI Sports Picks sent direct to your inbox.
Hedge Meaning in Betting | 4 Obvious Times to Hedge
Learn about hedge betting to manage risk and secure profits. Understand...
What is a Push in Betting? | 3 Ways To Use To Your Advantage
Understand what a push in betting means, how it happens in...
What Does the + and – Mean in Sports Betting? | 5 Easy Tips
Learn the basics of sports betting odds, what the plus (+)...
Denver vs Buffalo Prediction & Odds:
Free NFL Betting Insights for 1/12/25
Defensively, the Broncos boast a formidable pass rush, with players like Nik Bonitto and Jonathan Cooper achieving double-digit sacks. Buffalo’s defense, while solid, will need to account for Denver’s dynamic offensive weapons, including wide receiver Courtland Sutton. The game is expected to be a strategic battle, with both teams looking to exploit the other’s weaknesses. Weather conditions in Buffalo could also play a role, potentially impacting game plans and execution. Overall, this matchup offers an intriguing blend of veteran leadership and emerging talent, setting the stage for an exciting playoff encounter.
"These are the moments that people remember you by."
— Denver Broncos (@Broncos) January 9, 2025
QB Bo Nix, CB Pat Surtain II among Broncos readying for first playoff starts » https://t.co/41uHtyjIDz pic.twitter.com/82O8x9zJV0
Denver Broncos NFL Preview
The Buffalo Bills enter the playoffs with a 13-4 record, securing the second seed in the AFC. Under head coach Sean McDermott, the Bills have developed into one of the league’s most balanced teams. Offensively, quarterback Josh Allen has been exceptional, leading a unit that has consistently put up high point totals. Wide receivers Stefon Diggs and Gabriel Davis provide Allen with reliable targets, contributing to the team’s explosive passing game. The running game, complemented by running back James Cook, adds balance to the offense. Defensively, the Bills are stout, with a secondary led by Tre’Davious White and a pass rush featuring Von Miller. Buffalo’s defense ranks among the top in the league in points allowed, showcasing their ability to stifle opposing offenses. Special teams, anchored by kicker Tyler Bass, have been reliable throughout the season. The Bills’ home-field advantage at Highmark Stadium has been significant, with the team covering the spread in six of their last seven home games. As they prepare to face the Broncos, the Bills will look to leverage their balanced attack and home-field advantage to advance further in the playoffs.
Credit: USA TODAY/IMAGN
Buffalo Bills NFL Preview
The Buffalo Bills enter the playoffs with a 13-4 record, securing the second seed in the AFC. Under head coach Sean McDermott, the Bills have developed into one of the league’s most balanced teams. Offensively, quarterback Josh Allen has been exceptional, leading a unit that has consistently put up high point totals. Wide receivers Stefon Diggs and Gabriel Davis provide Allen with reliable targets, contributing to the team’s explosive passing game. The running game, complemented by running back James Cook, adds balance to the offense. Defensively, the Bills are stout, with a secondary led by Tre’Davious White and a pass rush featuring Von Miller. Buffalo’s defense ranks among the top in the league in points allowed, showcasing their ability to stifle opposing offenses. Special teams, anchored by kicker Tyler Bass, have been reliable throughout the season. The Bills’ home-field advantage at Highmark Stadium has been significant, with the team covering the spread in six of their last seven home games. As they prepare to face the Broncos, the Bills will look to leverage their balanced attack and home-field advantage to advance further in the playoffs.
A great season for the Safety First Campaign!
— Buffalo Bills (@BuffaloBills) January 9, 2025
For every tackle made by a Bills safety this season, @NationalGridNY donated $50 to benefit local first responders and their families. #BillsMafia pic.twitter.com/SfENWo2vbY
Denver vs. Buffalo Prop Picks (AI)
Denver vs. Buffalo Prediction (AI)
Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every angle between the Broncos and Bills and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.
The Algorithm has been most fixated on the unproportionally assigned emphasis knucklehead sportsbettors often put on coaching factors between a Broncos team going up against a possibly improved Bills team. We’ve found the true game analytics might reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Denver vs Buffalo picks, computer picks Broncos vs Bills, best bets, model edges, confidence ratings.
 |
DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
|---|---|---|---|---|---|---|
| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 6 |
VAULT v3
|
|
| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 4 |
EXECUTIVE
|
|
| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 4 |
EXECUTIVE
|
|
| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 1 |
INTEL
|
|
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Broncos Betting Trends
The Broncos have demonstrated resilience against the spread (ATS) this season. Notably, they have covered the spread in four of their last five games, indicating a strong finish to the regular season. On the road, Denver has been competitive, achieving a 3-2 ATS record in their last five away games. This suggests that the Broncos have the capability to perform well, even in challenging environments.
Bills Betting Trends
The Bills have been formidable ATS, particularly at home. They have covered the spread in six of their last seven games at Highmark Stadium, showcasing their dominance on home turf. Overall, Buffalo holds a 5-2 ATS record in their last seven games, reflecting consistent performance against betting expectations.
Broncos vs. Bills Matchup Trends
An interesting ATS statistic for this matchup is the Bills’ recent success against the Broncos. Buffalo has covered the spread in three of their last four meetings with Denver. This trend may influence betting perspectives, highlighting the Bills’ historical advantage in this pairing.
Denver vs. Buffalo Game Info
What time does Denver vs Buffalo start on January 12, 2025?
Denver vs Buffalo starts on January 12, 2025 at 2:00 PM EST.
Where is Denver vs Buffalo being played?
Venue: Highmark Stadium.
What are the opening odds for Denver vs Buffalo?
Spread: Buffalo -8.5
Moneyline: Denver +346, Buffalo -446
Over/Under: 47
What are the records for Denver vs Buffalo?
Denver: (10-7) | Buffalo: (13-4)
What is the AI best bet for Denver vs Buffalo?
Remi's searched hard and found the perfect prop bet for this game: WR Amari Cooper Over 3.5 Targets. Prices move—always shop for the best number.
What are Denver vs Buffalo trending bets?
An interesting ATS statistic for this matchup is the Bills’ recent success against the Broncos. Buffalo has covered the spread in three of their last four meetings with Denver. This trend may influence betting perspectives, highlighting the Bills’ historical advantage in this pairing.
What are Denver trending bets?
DEN trend: The Broncos have demonstrated resilience against the spread (ATS) this season. Notably, they have covered the spread in four of their last five games, indicating a strong finish to the regular season. On the road, Denver has been competitive, achieving a 3-2 ATS record in their last five away games. This suggests that the Broncos have the capability to perform well, even in challenging environments.
What are Buffalo trending bets?
BUF trend: The Bills have been formidable ATS, particularly at home. They have covered the spread in six of their last seven games at Highmark Stadium, showcasing their dominance on home turf. Overall, Buffalo holds a 5-2 ATS record in their last seven games, reflecting consistent performance against betting expectations.
Where can I find AI Picks for Denver vs Buffalo?
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Denver vs. Buffalo Odds
AI algorithm Remi is pouring through mountains of stats on each line. In fact, anytime the Denver vs Buffalo trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable betting trends.
Denver vs Buffalo Opening Odds
DEN Moneyline:
+346 BUF Moneyline: -446
DEN Spread: +8.5
BUF Spread: -8.5
Over/Under: 47
Denver vs Buffalo Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Nov 13, 2025 8:15PM EST
New York Jets
New England Patriots
11/13/25 8:15PM
Jets
Patriots
|
–
–
|
+534
-750
|
+11.5 (-103)
-11.5 (-107)
|
O 43 (-107)
U 43 (-107)
|
|
|
Nov 16, 2025 9:30AM EST
Washington Commanders
Miami Dolphins
11/16/25 9:30AM
Commanders
Dolphins
|
–
–
|
+132
-152
|
+3 (-107)
-3 (-103)
|
O 47.5 (-109)
U 47.5 (-105)
|
|
|
Nov 16, 2025 1:00PM EST
Carolina Panthers
Atlanta Falcons
11/16/25 1PM
Panthers
Falcons
|
–
–
|
+165
-190
|
+3.5 (-110)
-3.5 (+100)
|
O 42.5 (-107)
U 42.5 (-107)
|
|
|
Nov 16, 2025 1:00PM EST
Chicago Bears
Minnesota Vikings
11/16/25 1PM
Bears
Vikings
|
–
–
|
+142
-162
|
+3 (-105)
-3 (-105)
|
O 49 (-113)
U 49 (-102)
|
|
|
Nov 16, 2025 1:00PM EST
Los Angeles Chargers
Jacksonville Jaguars
11/16/25 1PM
Chargers
Jaguars
|
–
–
|
-150
+130
|
-2.5 (-118)
+2.5 (+107)
|
O 44 (-107)
U 44 (-107)
|
|
|
Nov 16, 2025 1:00PM EST
Green Bay Packers
New York Giants
11/16/25 1PM
Packers
Giants
|
–
–
|
-450
+350
|
-7.5 (-114)
+7.5 (-106)
|
O 44.5 (-105)
U 44.5 (-115)
|
|
|
Nov 16, 2025 1:00PM EST
Cincinnati Bengals
Pittsburgh Steelers
11/16/25 1PM
Bengals
Steelers
|
–
–
|
+200
-240
|
+5.5 (-110)
-5.5 (+100)
|
O 48.5 (-107)
U 48.5 (-107)
|
|
|
Nov 16, 2025 1:00PM EST
Tampa Bay Buccaneers
Buffalo Bills
11/16/25 1PM
Buccaneers
Bills
|
–
–
|
+215
-260
|
+5.5 (-105)
-5.5 (-105)
|
O 49 (-107)
U 49 (-107)
|
|
|
Nov 16, 2025 1:00PM EST
Houston Texans
Tennessee Titans
11/16/25 1PM
Texans
Titans
|
–
–
|
-355
+285
|
-7 (-108)
+7 (-102)
|
O 39 (-114)
U 39 (-101)
|
|
|
Nov 16, 2025 4:05PM EST
San Francisco 49ers
Arizona Cardinals
11/16/25 4:05PM
49ers
Cardinals
|
–
–
|
-140
+120
|
-2.5 (-105)
+2.5 (-105)
|
O 48.5 (-107)
U 48.5 (-107)
|
|
|
Nov 16, 2025 4:05PM EST
Seattle Seahawks
Los Angeles Rams
11/16/25 4:05PM
Seahawks
Rams
|
–
–
|
+130
-150
|
+2.5 (+104)
-2.5 (-115)
|
O 49 (-102)
U 49 (-113)
|
|
|
Nov 16, 2025 4:25PM EST
Kansas City Chiefs
Denver Broncos
11/16/25 4:25PM
Chiefs
Broncos
|
–
–
|
-200
+174
|
-4 (-103)
+4 (-107)
|
O 44.5 (-107)
U 44.5 (-107)
|
|
|
Nov 16, 2025 4:25PM EST
Baltimore Ravens
Cleveland Browns
11/16/25 4:25PM
Ravens
Browns
|
–
–
|
-425
+334
|
-8.5 (-102)
+8.5 (-108)
|
O 40.5 (-118)
U 40.5 (+103)
|
|
|
Nov 16, 2025 8:20PM EST
Detroit Lions
Philadelphia Eagles
11/16/25 8:20PM
Lions
Eagles
|
–
–
|
+106
-124
|
+1.5 (-110)
-1.5 (-110)
|
O 48.5 (-105)
U 48.5 (-115)
|
|
|
Nov 17, 2025 8:15PM EST
Dallas Cowboys
Las Vegas Raiders
11/17/25 8:15PM
Cowboys
Raiders
|
–
–
|
-185
+161
|
-3.5 (-105)
+3.5 (-105)
|
O 50 (-107)
U 50 (-107)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Denver Broncos vs. Buffalo Bills on January 12, 2025 at Highmark Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| LV@DEN | RILEY MOSS OVER 4.5 TACKLE + ASST | 54.8% | 4 | WIN |
| LV@DEN | UNDER 43 | 53.4% | 2 | WIN |
| ARI@DAL | BUDDA BAKER OVER 7.5 TACKLES + ASSTS | 54.4% | 4 | WIN |
| ARI@DAL | GEORGE PICKENS OVER 4.5 RECEPTIONS | 56.6% | 6 | WIN |
| DEN@HOU | WIL LUTZ OVER 1.5 MADE FIELD GOALS | 54.2% | 3 | LOSS |
| SEA@WAS | SEA -3 | 56.7% | 6 | WIN |
| IND@PIT | IND -3 | 56.8% | 6 | LOSS |
| LAC@TEN | LAC -9.5 | 56.2% | 6 | LOSS |
| CHI@CIN | CHI -2.5 | 52.6% | 2 | WIN |
| SEA@WAS | OVER 48 | 52.9% | 2 | WIN |
| SEA@WAS | JAYDEN DANIELS OVER 20.5 PASS COMP | 56.7% | 6 | LOSS |
| JAC@LV | JAC -140 | 64.2% | 7 | WIN |
| NO@LAR | LAR -14 | 55.0% | 4 | WIN |
| DEN@HOU | HOU -1.5 | 54.2% | 3 | LOSS |
| CAR@GB | GB -12.5 | 55.4% | 5 | LOSS |
| SF@NYG | NYG +2.5 | 56.1% | 5 | LOSS |
| BAL@MIA | TUA TAGOVAILOA UNDER 0.5 INT | 55.3% | 5 | LOSS |
| TB@NO | TB -3.5 | 52.3% | 1 | WIN |
| GB@PIT | GB -2.5 | 52.3% | 1 | WIN |
| SF@HOU | SF +2.5 | 56.0% | 6 | LOSS |
| NYG@PHI | NYG +7.5 | 53.9% | 3 | LOSS |
| BUF@CAR | CAR +7.5 | 54.2% | 3 | LOSS |
| DAL@DEN | DAL +3.5 | 55.0% | 4 | LOSS |
| MIA@ATL | MIA +7 | 54.3% | 4 | WIN |
| CLE@NE | CLE +7 | 56.8% | 6 | LOSS |
| TB@NO | BAKER MAYFIELD OVER 15.5 RUSH YDS | 56.6% | 6 | LOSS |
| MIN@LAC | JUSTIN HERBERT PASS ATT UNDER 35.5 | 55.5% | 5 | WIN |
| TB@DET | TB +6.5 | 54.4% | 4 | LOSS |
| TB@DET | RACHAAD WHITE UNDER 14.5 RUSH ATT | 54.4% | 4 | WIN |
| NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
| CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
| PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
| GB@ARI | ARI +7 | 54.8% | 5 | WIN |
| NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
| WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
| GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
| PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
| BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
| CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
| TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
| DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
| SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
| LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
| ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
| TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
| LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
| SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
| CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
| DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
| KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
| KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |