Broncos vs Bills Prediction — AI Finds CAN'T MISS NFL Lines & Props (Jan 12)
Updated: 2025-01-05T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Denver Broncos are set to face the Buffalo Bills in an AFC Wild Card matchup on January 12, 2025, at Highmark Stadium in Buffalo. The Bills, boasting a 13-4 record, are favored by 8.5 points, while the Broncos, entering the playoffs for the first time since their 2016 Super Bowl victory, hold a 10-7 record.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Jan 12, 2025
Start Time: 2:00 PM EST
Venue: Highmark Stadium
Bills Record: (13-4)
Broncos Record: (10-7)
OPENING ODDS
DEN Moneyline: +346
BUF Moneyline: -446
DEN Spread: +8.5
BUF Spread: -8.5
Over/Under: 47
DEN
Betting Trends
- The Broncos have demonstrated resilience against the spread (ATS) this season. Notably, they have covered the spread in four of their last five games, indicating a strong finish to the regular season. On the road, Denver has been competitive, achieving a 3-2 ATS record in their last five away games. This suggests that the Broncos have the capability to perform well, even in challenging environments.
BUF
Betting Trends
- The Bills have been formidable ATS, particularly at home. They have covered the spread in six of their last seven games at Highmark Stadium, showcasing their dominance on home turf. Overall, Buffalo holds a 5-2 ATS record in their last seven games, reflecting consistent performance against betting expectations.
MATCHUP TRENDS
- An interesting ATS statistic for this matchup is the Bills’ recent success against the Broncos. Buffalo has covered the spread in three of their last four meetings with Denver. This trend may influence betting perspectives, highlighting the Bills’ historical advantage in this pairing.
DEN vs. BUF
Best Prop Bet
- Remi's searched hard and found the perfect prop bet for this game: WR Amari Cooper Over 3.5 Targets
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Denver vs Buffalo Prediction & Odds:
Free NFL Betting Insights for 1/12/25
Defensively, the Broncos boast a formidable pass rush, with players like Nik Bonitto and Jonathan Cooper achieving double-digit sacks. Buffalo’s defense, while solid, will need to account for Denver’s dynamic offensive weapons, including wide receiver Courtland Sutton. The game is expected to be a strategic battle, with both teams looking to exploit the other’s weaknesses. Weather conditions in Buffalo could also play a role, potentially impacting game plans and execution. Overall, this matchup offers an intriguing blend of veteran leadership and emerging talent, setting the stage for an exciting playoff encounter.
"These are the moments that people remember you by."
— Denver Broncos (@Broncos) January 9, 2025
QB Bo Nix, CB Pat Surtain II among Broncos readying for first playoff starts » https://t.co/41uHtyjIDz pic.twitter.com/82O8x9zJV0
Denver Broncos NFL Preview
The Buffalo Bills enter the playoffs with a 13-4 record, securing the second seed in the AFC. Under head coach Sean McDermott, the Bills have developed into one of the league’s most balanced teams. Offensively, quarterback Josh Allen has been exceptional, leading a unit that has consistently put up high point totals. Wide receivers Stefon Diggs and Gabriel Davis provide Allen with reliable targets, contributing to the team’s explosive passing game. The running game, complemented by running back James Cook, adds balance to the offense. Defensively, the Bills are stout, with a secondary led by Tre’Davious White and a pass rush featuring Von Miller. Buffalo’s defense ranks among the top in the league in points allowed, showcasing their ability to stifle opposing offenses. Special teams, anchored by kicker Tyler Bass, have been reliable throughout the season. The Bills’ home-field advantage at Highmark Stadium has been significant, with the team covering the spread in six of their last seven home games. As they prepare to face the Broncos, the Bills will look to leverage their balanced attack and home-field advantage to advance further in the playoffs.
Credit: USA TODAY/IMAGN
Buffalo Bills NFL Preview
The Buffalo Bills enter the playoffs with a 13-4 record, securing the second seed in the AFC. Under head coach Sean McDermott, the Bills have developed into one of the league’s most balanced teams. Offensively, quarterback Josh Allen has been exceptional, leading a unit that has consistently put up high point totals. Wide receivers Stefon Diggs and Gabriel Davis provide Allen with reliable targets, contributing to the team’s explosive passing game. The running game, complemented by running back James Cook, adds balance to the offense. Defensively, the Bills are stout, with a secondary led by Tre’Davious White and a pass rush featuring Von Miller. Buffalo’s defense ranks among the top in the league in points allowed, showcasing their ability to stifle opposing offenses. Special teams, anchored by kicker Tyler Bass, have been reliable throughout the season. The Bills’ home-field advantage at Highmark Stadium has been significant, with the team covering the spread in six of their last seven home games. As they prepare to face the Broncos, the Bills will look to leverage their balanced attack and home-field advantage to advance further in the playoffs.
A great season for the Safety First Campaign!
— Buffalo Bills (@BuffaloBills) January 9, 2025
For every tackle made by a Bills safety this season, @NationalGridNY donated $50 to benefit local first responders and their families. #BillsMafia pic.twitter.com/SfENWo2vbY
Denver vs. Buffalo Prop Picks (AI)
Denver vs. Buffalo Prediction (AI)
Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every angle between the Broncos and Bills and using recursive machine learning and industry leading AI to examine the data to a single cover probability.
Interestingly enough, the data has been most fixated on the linear correlation of weight human bettors tend to put on player performance factors between a Broncos team going up against a possibly healthy Bills team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Denver vs Buffalo picks, computer picks Broncos vs Bills, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 5 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 1 |
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| NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 0 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Broncos Betting Trends
The Broncos have demonstrated resilience against the spread (ATS) this season. Notably, they have covered the spread in four of their last five games, indicating a strong finish to the regular season. On the road, Denver has been competitive, achieving a 3-2 ATS record in their last five away games. This suggests that the Broncos have the capability to perform well, even in challenging environments.
Bills Betting Trends
The Bills have been formidable ATS, particularly at home. They have covered the spread in six of their last seven games at Highmark Stadium, showcasing their dominance on home turf. Overall, Buffalo holds a 5-2 ATS record in their last seven games, reflecting consistent performance against betting expectations.
Broncos vs. Bills Matchup Trends
An interesting ATS statistic for this matchup is the Bills’ recent success against the Broncos. Buffalo has covered the spread in three of their last four meetings with Denver. This trend may influence betting perspectives, highlighting the Bills’ historical advantage in this pairing.
Denver vs. Buffalo Game Info
What time does Denver vs Buffalo start on January 12, 2025?
Denver vs Buffalo starts on January 12, 2025 at 2:00 PM EST.
Where is Denver vs Buffalo being played?
Venue: Highmark Stadium.
What are the opening odds for Denver vs Buffalo?
Spread: Buffalo -8.5
Moneyline: Denver +346, Buffalo -446
Over/Under: 47
What are the records for Denver vs Buffalo?
Denver: (10-7) | Buffalo: (13-4)
What is the AI best bet for Denver vs Buffalo?
Remi's searched hard and found the perfect prop bet for this game: WR Amari Cooper Over 3.5 Targets. Prices move—always shop for the best number.
What are Denver vs Buffalo trending bets?
An interesting ATS statistic for this matchup is the Bills’ recent success against the Broncos. Buffalo has covered the spread in three of their last four meetings with Denver. This trend may influence betting perspectives, highlighting the Bills’ historical advantage in this pairing.
What are Denver trending bets?
DEN trend: The Broncos have demonstrated resilience against the spread (ATS) this season. Notably, they have covered the spread in four of their last five games, indicating a strong finish to the regular season. On the road, Denver has been competitive, achieving a 3-2 ATS record in their last five away games. This suggests that the Broncos have the capability to perform well, even in challenging environments.
What are Buffalo trending bets?
BUF trend: The Bills have been formidable ATS, particularly at home. They have covered the spread in six of their last seven games at Highmark Stadium, showcasing their dominance on home turf. Overall, Buffalo holds a 5-2 ATS record in their last seven games, reflecting consistent performance against betting expectations.
Where can I find AI Picks for Denver vs Buffalo?
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Denver vs. Buffalo Odds
Remi is pouring through tons of data on each team. In fact, anytime the Denver vs Buffalo trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable betting trends.
Denver vs Buffalo Opening Odds
DEN Moneyline:
+346 BUF Moneyline: -446
DEN Spread: +8.5
BUF Spread: -8.5
Over/Under: 47
Denver vs Buffalo Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
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Los Angeles Chargers
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Chargers
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–
–
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+142
-170
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+3 (-110)
-3 (-110)
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O 44.5 (-110)
U 44.5 (-110)
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–
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+275
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+7 (-118)
-7 (-102)
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O 40.5 (-110)
U 40.5 (-110)
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Panthers
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–
–
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-360
+285
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-7.5 (-105)
+7.5 (-115)
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O 45.5 (-115)
U 45.5 (-105)
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–
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+270
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+7 (-115)
-7 (-105)
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O 44.5 (-105)
U 44.5 (-115)
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Baltimore Ravens
10/26/25 1PM
Bears
Ravens
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–
–
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+260
-325
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+6.5 (-110)
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O 49.5 (-120)
U 49.5 (+100)
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Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
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–
–
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+280
-355
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+7 (-110)
-7 (-110)
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O 43.5 (-115)
U 43.5 (-105)
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Oct 26, 2025 1:00PM EDT
San Francisco 49ers
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10/26/25 1PM
49ers
Texans
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–
–
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+102
-122
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+1.5 (-112)
-1.5 (-108)
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O 41.5 (-110)
U 41.5 (-110)
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Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
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–
–
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+285
-360
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+7 (-105)
-7 (-115)
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O 44.5 (-112)
U 44.5 (-108)
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Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
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–
–
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-230
+190
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-4.5 (-110)
+4.5 (-110)
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O 46.5 (-112)
U 46.5 (-108)
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Oct 26, 2025 4:25PM EDT
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Denver Broncos
10/26/25 4:25PM
Cowboys
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|
–
–
|
+150
-180
|
+3.5 (-118)
-3.5 (-102)
|
O 50.5 (-108)
U 50.5 (-112)
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Oct 26, 2025 4:25PM EDT
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Titans
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–
–
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+675
-1050
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+14 (-110)
-14 (-110)
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O 47.5 (-105)
U 47.5 (-115)
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Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
|
–
–
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-185
+154
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-3 (-118)
+3 (-102)
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O 44.5 (-112)
U 44.5 (-108)
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Oct 27, 2025 8:15PM EDT
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Kansas City Chiefs
10/27/25 8:15PM
Commanders
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–
–
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+455
-625
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+10 (-105)
-10 (-115)
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O 47.5 (-110)
U 47.5 (-110)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Denver Broncos vs. Buffalo Bills on January 12, 2025 at Highmark Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
| CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
| PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
| GB@ARI | ARI +7 | 54.8% | 5 | WIN |
| NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
| WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
| GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
| PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
| BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
| CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
| TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
| DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
| SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
| LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
| ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
| TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
| LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
| SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
| CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
| DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
| KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
| KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
| HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
| DET@CIN | DET -10 | 55.6% | 5 | WIN |
| DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
| TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
| TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
| DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
| MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
| LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
| SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
| NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
| CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
| NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
| CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
| NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
| CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
| WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
| BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
| TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
| LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
| NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
| GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
| CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |