Broncos vs. Bills
Prediction, Odds & Props
Jan 12 | NFL AI Picks
Updated: 2025-01-05T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Denver Broncos are set to face the Buffalo Bills in an AFC Wild Card matchup on January 12, 2025, at Highmark Stadium in Buffalo. The Bills, boasting a 13-4 record, are favored by 8.5 points, while the Broncos, entering the playoffs for the first time since their 2016 Super Bowl victory, hold a 10-7 record.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Jan 12, 2025
Start Time: 2:00 PM EST
Venue: Highmark Stadium
Bills Record: (13-4)
Broncos Record: (10-7)
OPENING ODDS
DEN Moneyline: +346
BUF Moneyline: -446
DEN Spread: +8.5
BUF Spread: -8.5
Over/Under: 47
DEN
Betting Trends
- The Broncos have demonstrated resilience against the spread (ATS) this season. Notably, they have covered the spread in four of their last five games, indicating a strong finish to the regular season. On the road, Denver has been competitive, achieving a 3-2 ATS record in their last five away games. This suggests that the Broncos have the capability to perform well, even in challenging environments.
BUF
Betting Trends
- The Bills have been formidable ATS, particularly at home. They have covered the spread in six of their last seven games at Highmark Stadium, showcasing their dominance on home turf. Overall, Buffalo holds a 5-2 ATS record in their last seven games, reflecting consistent performance against betting expectations.
MATCHUP TRENDS
- An interesting ATS statistic for this matchup is the Bills’ recent success against the Broncos. Buffalo has covered the spread in three of their last four meetings with Denver. This trend may influence betting perspectives, highlighting the Bills’ historical advantage in this pairing.
DEN vs. BUF
Best Prop Bet
- Remi's searched hard and found the perfect prop bet for this game: WR Amari Cooper Over 3.5 Targets
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Denver vs Buffalo Prediction & Odds:
Free NFL Betting Insights for 1/12/25
Defensively, the Broncos boast a formidable pass rush, with players like Nik Bonitto and Jonathan Cooper achieving double-digit sacks. Buffalo’s defense, while solid, will need to account for Denver’s dynamic offensive weapons, including wide receiver Courtland Sutton. The game is expected to be a strategic battle, with both teams looking to exploit the other’s weaknesses. Weather conditions in Buffalo could also play a role, potentially impacting game plans and execution. Overall, this matchup offers an intriguing blend of veteran leadership and emerging talent, setting the stage for an exciting playoff encounter.
"These are the moments that people remember you by."
— Denver Broncos (@Broncos) January 9, 2025
QB Bo Nix, CB Pat Surtain II among Broncos readying for first playoff starts » https://t.co/41uHtyjIDz pic.twitter.com/82O8x9zJV0
Denver Broncos NFL Preview
The Buffalo Bills enter the playoffs with a 13-4 record, securing the second seed in the AFC. Under head coach Sean McDermott, the Bills have developed into one of the league’s most balanced teams. Offensively, quarterback Josh Allen has been exceptional, leading a unit that has consistently put up high point totals. Wide receivers Stefon Diggs and Gabriel Davis provide Allen with reliable targets, contributing to the team’s explosive passing game. The running game, complemented by running back James Cook, adds balance to the offense. Defensively, the Bills are stout, with a secondary led by Tre’Davious White and a pass rush featuring Von Miller. Buffalo’s defense ranks among the top in the league in points allowed, showcasing their ability to stifle opposing offenses. Special teams, anchored by kicker Tyler Bass, have been reliable throughout the season. The Bills’ home-field advantage at Highmark Stadium has been significant, with the team covering the spread in six of their last seven home games. As they prepare to face the Broncos, the Bills will look to leverage their balanced attack and home-field advantage to advance further in the playoffs.
Credit: USA TODAY/IMAGN
Buffalo Bills NFL Preview
The Buffalo Bills enter the playoffs with a 13-4 record, securing the second seed in the AFC. Under head coach Sean McDermott, the Bills have developed into one of the league’s most balanced teams. Offensively, quarterback Josh Allen has been exceptional, leading a unit that has consistently put up high point totals. Wide receivers Stefon Diggs and Gabriel Davis provide Allen with reliable targets, contributing to the team’s explosive passing game. The running game, complemented by running back James Cook, adds balance to the offense. Defensively, the Bills are stout, with a secondary led by Tre’Davious White and a pass rush featuring Von Miller. Buffalo’s defense ranks among the top in the league in points allowed, showcasing their ability to stifle opposing offenses. Special teams, anchored by kicker Tyler Bass, have been reliable throughout the season. The Bills’ home-field advantage at Highmark Stadium has been significant, with the team covering the spread in six of their last seven home games. As they prepare to face the Broncos, the Bills will look to leverage their balanced attack and home-field advantage to advance further in the playoffs.
A great season for the Safety First Campaign!
— Buffalo Bills (@BuffaloBills) January 9, 2025
For every tackle made by a Bills safety this season, @NationalGridNY donated $50 to benefit local first responders and their families. #BillsMafia pic.twitter.com/SfENWo2vbY
Denver vs. Buffalo Prop Picks (AI)
Denver vs. Buffalo Prediction (AI)
Remi, our AI sports algorithm, has been pouring over millions of data from every simulation between the Broncos and Bills and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most focused on the growing weight human bettors tend to put on Buffalo’s strength factors between a Broncos team going up against a possibly improved Bills team. It appears the true game analytics appear to reflect a moderate lean against one Vegas line specifically.
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Below is our current AI Denver vs Buffalo picks, computer picks Broncos vs Bills, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NFL | 9/28 | LAC@NYG | UNLOCK THIS PICK | 7 |
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| NFL | 9/28 | TEN@HOU | UNLOCK THIS PICK | 7 |
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| NFL | 9/28 | CAR@NE | UNLOCK THIS PICK | 6 |
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| NFL | 9/28 | BAL@KC | UNLOCK THIS PICK | 6 |
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| NFL | 9/28 | GB@DAL | UNLOCK THIS PICK | 5 |
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| NFL | 9/28 | WAS@ATL | UNLOCK THIS PICK | 4 |
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| NFL | 9/28 | NO@BUF | UNLOCK THIS PICK | 3 |
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| NFL | 9/28 | GB@DAL | UNLOCK THIS PICK | 2 |
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| NFL | 9/28 | CHI@LV | GET FREE PICK NOW | 2 | – | |
| NFL | 9/28 | PHI@TB | UNLOCK THIS PICK | 10 |
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| NFL | 9/28 | BAL@KC | UNLOCK THIS PICK | 0 |
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| NFL | 9/28 | IND@LAR | UNLOCK THIS PICK | 1 |
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| NFL | 9/28 | CAR@NE | UNLOCK THIS PICK | 0 |
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| NFL | 9/28 | GB@DAL | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Broncos Betting Trends
The Broncos have demonstrated resilience against the spread (ATS) this season. Notably, they have covered the spread in four of their last five games, indicating a strong finish to the regular season. On the road, Denver has been competitive, achieving a 3-2 ATS record in their last five away games. This suggests that the Broncos have the capability to perform well, even in challenging environments.
Bills Betting Trends
The Bills have been formidable ATS, particularly at home. They have covered the spread in six of their last seven games at Highmark Stadium, showcasing their dominance on home turf. Overall, Buffalo holds a 5-2 ATS record in their last seven games, reflecting consistent performance against betting expectations.
Broncos vs. Bills Matchup Trends
An interesting ATS statistic for this matchup is the Bills’ recent success against the Broncos. Buffalo has covered the spread in three of their last four meetings with Denver. This trend may influence betting perspectives, highlighting the Bills’ historical advantage in this pairing.
Denver vs. Buffalo Game Info
What time does Denver vs Buffalo start on January 12, 2025?
Denver vs Buffalo starts on January 12, 2025 at 2:00 PM EST.
Where is Denver vs Buffalo being played?
Venue: Highmark Stadium.
What are the opening odds for Denver vs Buffalo?
Spread: Buffalo -8.5
Moneyline: Denver +346, Buffalo -446
Over/Under: 47
What are the records for Denver vs Buffalo?
Denver: (10-7) | Buffalo: (13-4)
What is the AI best bet for Denver vs Buffalo?
Remi's searched hard and found the perfect prop bet for this game: WR Amari Cooper Over 3.5 Targets. Prices move—always shop for the best number.
What are Denver vs Buffalo trending bets?
An interesting ATS statistic for this matchup is the Bills’ recent success against the Broncos. Buffalo has covered the spread in three of their last four meetings with Denver. This trend may influence betting perspectives, highlighting the Bills’ historical advantage in this pairing.
What are Denver trending bets?
DEN trend: The Broncos have demonstrated resilience against the spread (ATS) this season. Notably, they have covered the spread in four of their last five games, indicating a strong finish to the regular season. On the road, Denver has been competitive, achieving a 3-2 ATS record in their last five away games. This suggests that the Broncos have the capability to perform well, even in challenging environments.
What are Buffalo trending bets?
BUF trend: The Bills have been formidable ATS, particularly at home. They have covered the spread in six of their last seven games at Highmark Stadium, showcasing their dominance on home turf. Overall, Buffalo holds a 5-2 ATS record in their last seven games, reflecting consistent performance against betting expectations.
Where can I find AI Picks for Denver vs Buffalo?
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Denver vs. Buffalo Odds
Remi is pouring through mountains of stats on each team. In fact, anytime the Denver vs Buffalo trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable betting trends.
Denver vs Buffalo Opening Odds
DEN Moneyline:
+346 BUF Moneyline: -446
DEN Spread: +8.5
BUF Spread: -8.5
Over/Under: 47
Denver vs Buffalo Live Odds
| Games | PTS | ML | SPR | O/U | |
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In Progress
Green Bay Packers
Dallas Cowboys
In Progress
Packers
Cowboys
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13
16
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-166
+130
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-1.5 (-120)
+1.5 (-110)
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O 51.5 (-125)
U 51.5 (-105)
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Sep 29, 2025 7:16PM EDT
New York Jets
Miami Dolphins
9/29/25 7:16PM
Jets
Dolphins
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–
–
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+130
-155
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+2.5 (-102)
-2.5 (-118)
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O 45.5 (-105)
U 45.5 (-115)
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Sep 29, 2025 8:16PM EDT
Cincinnati Bengals
Denver Broncos
9/29/25 8:16PM
Bengals
Broncos
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–
–
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+390
-520
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+7.5 (-110)
-7.5 (-110)
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O 44.5 (-105)
U 44.5 (-115)
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Oct 2, 2025 7:16PM EDT
San Francisco 49ers
Los Angeles Rams
10/2/25 7:16PM
49ers
Rams
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–
–
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+150
-180
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+3 (+100)
-3 (-120)
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O 47.5 (-105)
U 47.5 (-115)
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Oct 5, 2025 8:31AM EDT
Minnesota Vikings
Cleveland Browns
10/5/25 8:31AM
Vikings
Browns
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–
–
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-218
+180
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-4.5 (-110)
+4.5 (-110)
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O 37.5 (-110)
U 37.5 (-110)
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Oct 5, 2025 12:01PM EDT
Las Vegas Raiders
Indianapolis Colts
10/5/25 12:01PM
Raiders
Colts
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–
–
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+240
-298
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+6.5 (-110)
-6.5 (-110)
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O 48.5 (-105)
U 48.5 (-115)
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Oct 5, 2025 12:01PM EDT
New York Giants
New Orleans Saints
10/5/25 12:01PM
Giants
Saints
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–
–
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-135
+114
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-2.5 (-110)
+2.5 (-110)
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O 42.5 (-110)
U 42.5 (-110)
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Oct 5, 2025 12:01PM EDT
Denver Broncos
Philadelphia Eagles
10/5/25 12:01PM
Broncos
Eagles
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–
–
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+195
-238
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+5.5 (-110)
-5.5 (-110)
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O 43.5 (-115)
U 43.5 (-105)
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Oct 5, 2025 12:01PM EDT
Miami Dolphins
Carolina Panthers
10/5/25 12:01PM
Dolphins
Panthers
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–
–
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-125
+105
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-1.5 (-110)
+1.5 (-110)
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O 46.5 (-110)
U 46.5 (-110)
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Oct 5, 2025 3:06PM EDT
Tampa Bay Buccaneers
Seattle Seahawks
10/5/25 3:06PM
Buccaneers
Seahawks
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–
–
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+114
-135
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+2.5 (-110)
-2.5 (-110)
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O 45.5 (-110)
U 45.5 (-110)
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Oct 5, 2025 3:06PM EDT
Tennessee Titans
Arizona Cardinals
10/5/25 3:06PM
Titans
Cardinals
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–
–
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+380
-500
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+8.5 (-105)
-8.5 (-115)
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O 41.5 (-105)
U 41.5 (-115)
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Oct 5, 2025 3:26PM EDT
Washington Commanders
Los Angeles Chargers
10/5/25 3:26PM
Commanders
Chargers
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–
–
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+140
-166
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+3 (-110)
-3 (-110)
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O 47.5 (-110)
U 47.5 (-110)
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Oct 5, 2025 3:26PM EDT
Detroit Lions
Cincinnati Bengals
10/5/25 3:26PM
Lions
Bengals
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–
–
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-440
+340
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-8.5 (-110)
+8.5 (-110)
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O 48.5 (-110)
U 48.5 (-110)
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Oct 5, 2025 7:21PM EDT
New England Patriots
Buffalo Bills
10/5/25 7:21PM
Patriots
Bills
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–
–
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+360
-470
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+8.5 (-110)
-8.5 (-110)
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O 50.5 (-110)
U 50.5 (-110)
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Oct 6, 2025 7:16PM EDT
Kansas City Chiefs
Jacksonville Jaguars
10/6/25 7:16PM
Chiefs
Jaguars
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–
–
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-166
+140
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-3 (-115)
+3 (-105)
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O 45.5 (-110)
U 45.5 (-110)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Denver Broncos vs. Buffalo Bills on January 12, 2025 at Highmark Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |
| GB@CLE | GB -7 | 54.3% | 4 | LOSS |
| ARI@SF | ARI +3 | 57.7% | 6 | WIN |
| KC@NYG | PATRICK MAHOMES OVER 230.5 PASS YDS | 54.7% | 4 | WIN |
| GB@CLE | JOE FLACCO OVER 37.5 PASS ATT | 56.6% | 6 | LOSS |
| MIA@BUF | TYREEK HILL OVER 5.5 TOTAL RECEPTIONS | 56.8% | 6 | LOSS |
| LAC@LV | LAC -3 | 54.9% | 4 | WIN |
| TB@HOU | BAKER MAYFIELD OVER 1.5 PASS TDS | 54.4% | 4 | WIN |
| CHI@DET | DET -6.5 | 54.3% | 4 | WIN |
| DEN@IND | DEN -118 | 60.1% | 10 | LOSS |
| PHI@KC | PHI -115 | 56.7% | 6 | WIN |
| SF@NO | SF -3 | 58.8% | 8 | WIN |
| SEA@PIT | OVER 40 | 54.9% | 4 | WIN |
| CAR@ARI | BRYCE YOUNG INTERCEPTIONS UNDER 0.5 | 56.4% | 6 | LOSS |
| DEN@IND | JOSH DOWNS RECEPTIONS OVER 3.5 | 54.7% | 4 | WIN |
| ATL@MIN | BIJAN ROBINSON RUSH + REC YDS OVER 94.5 | 53.4% | 3 | WIN |
| WAS@GB | WAS +3.5 | 56.5% | 6 | LOSS |
| WAS@GB | JORDAN LOVE OVER 5.5 RUSH YDS | 54.7% | 4 | WIN |
| MIN@CHI | CALEB WILLIAMS OVER 219.5 PASS YDS | 53.4% | 3 | LOSS |
| TEN@DEN | DEN -8.5 | 55.3% | 5 | LOSS |
| SF@SEA | SF -115 | 54.6% | 4 | WIN |
| SF@SEA | KENNETH WALKER III UNDER 79.5 RUSH+REC YDS | 54.6% | 4 | WIN |
| CAR@JAC | TANK BIGSBY OVER 10.5 RUSH ATT | 56.1% | 6 | LOSS |
| KC@LAC | JUSTIN HERBERT UNDER 0.5 INT | 54.1% | 3 | WIN |
| DAL@PHI | GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS | 54.1% | 4 | LOSS |
| KC@PHI | JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS | 53.90% | 5 | WIN |
| KC@PHI | DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS | 54.40% | 6 | WIN |
| KC@PHI | PATRICK MAHOMES UNDER 68.3% PASS COMP | 55.00% | 8 | WIN |
| KC@PHI | JALEN HURTS LONGEST RUSH OVER 12.5 YDS | 55.60% | 8 | WIN |
| BUF@KC | DALTON KINCAID OVER 29.5 RECV YDS | 55.10% | 8 | LOSS |
| WAS@PHI | DEVONTA SMITH OVER 3.5 RECEPTIONS | 55.80% | 8 | WIN |
| BUF@KC | JAMES COOK ANYTIME TD | 53.00% | 5 | WIN |
| LAR@PHI | SAQUON BARKLEY UNDER 128 RUSH + REC YDS | 53.20% | 5 | LOSS |
| BAL@BUF | LAMAR JACKSON OVER 54.5 RUSH YDS | 54.50% | 6 | LOSS |
| HOU@KC | C.J. STROUD RUSH YDS UNDER 14.5 | 53.10% | 5 | LOSS |
| WAS@DET | JAMESON WILLIAMS RUSH YDS OVER 1.5 | 53.30% | 5 | WIN |
| WAS@DET | JARED GOFF PASS COMP % UNDER 72.3 | 54.30% | 6 | WIN |
| MIN@LAR | COOPER KUPP ANYTIME TOUCHDOWN | 52.60% | 3 | LOSS |
| MIN@LAR | MATTHEW STAFFORD OVER 21.5 PASS COMP | 54.10% | 6 | LOSS |
| WAS@TB | BRIAN ROBINSON JR OVER 1.5 REC TARGETS | 53.50% | 5 | WIN |
| WAS@TB | BAKER MAYFIELD UNDER 33.5 PASS ATT | 54.90% | 6 | WIN |
| GB@PHI | JALEN HURTS OVER 67.1 PASS COMP PERCENTAGE | 54.60% | 6 | LOSS |
| LAC@HOU | J.K. DOBBINS ANYTIME TD | 52.80% | 3 | LOSS |
| LAC@HOU | LAC -2.5 | 53.40% | 3 | LOSS |
| LAC@HOU | JUSTIN HERBERT OVER 19.5 RUSH YDS | 53.40% | 5 | LOSS |