Broncos vs Bills Prediction — AI Finds CAN'T MISS NFL Lines & Props (Jan 12)

Updated: 2025-01-05T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Denver Broncos are set to face the Buffalo Bills in an AFC Wild Card matchup on January 12, 2025, at Highmark Stadium in Buffalo. The Bills, boasting a 13-4 record, are favored by 8.5 points, while the Broncos, entering the playoffs for the first time since their 2016 Super Bowl victory, hold a 10-7 record.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jan 12, 2025

Start Time: 2:00 PM EST​

Venue: Highmark Stadium​

Bills Record: (13-4)

Broncos Record: (10-7)

OPENING ODDS

DEN Moneyline: +346

BUF Moneyline: -446

DEN Spread: +8.5

BUF Spread: -8.5

Over/Under: 47

DEN
Betting Trends

  • The Broncos have demonstrated resilience against the spread (ATS) this season. Notably, they have covered the spread in four of their last five games, indicating a strong finish to the regular season. On the road, Denver has been competitive, achieving a 3-2 ATS record in their last five away games. This suggests that the Broncos have the capability to perform well, even in challenging environments.

BUF
Betting Trends

  • The Bills have been formidable ATS, particularly at home. They have covered the spread in six of their last seven games at Highmark Stadium, showcasing their dominance on home turf. Overall, Buffalo holds a 5-2 ATS record in their last seven games, reflecting consistent performance against betting expectations.

MATCHUP TRENDS

  • An interesting ATS statistic for this matchup is the Bills’ recent success against the Broncos. Buffalo has covered the spread in three of their last four meetings with Denver. This trend may influence betting perspectives, highlighting the Bills’ historical advantage in this pairing.

DEN vs. BUF
Best Prop Bet

  • Remi's searched hard and found the perfect prop bet for this game: WR Amari Cooper Over 3.5 Targets

LIVE NFL ODDS

NFL ODDS COMPARISON

WANT MORE AI PICKS?

VAULT
VS. SPREAD
325-240
VAULT
NET UNITS
(INCL VIG)
+395.4
VAULT
NET PROFIT
(INCL VIG)
$100/UNIT
$39,540
EXECUTIVE
VS. SPREAD
1593-1364
EXECUTIVE
NET UNITS
(INCL VIG)
+371.9
EXECUTIVE
NET PROFIT
(INCL VIG)
$100/UNIT
$37,192

AI SPORTS PICK PRODUCTS

Create a Free Account

‘Create an Account’ to Get Remi’s Picks Today.

Remi Finds New Picks

Remi calculates the probability a team will cover the line.

Remi Works 24/7

Remi uses this probability to assign units to each pick.

Get Remi's AI Picks

Get Remi’s Top AI Sports Picks sent direct to your inbox.

Denver vs Buffalo Prediction & Odds:
Free NFL Betting Insights for 1/12/25

The AFC Wild Card game between the Denver Broncos and the Buffalo Bills is poised to be a compelling contest. The Bills, led by quarterback Josh Allen, have exhibited a high-powered offense throughout the season, averaging over 30 points in eight of their last nine games. Allen’s dual-threat capability makes him a formidable challenge for any defense. The Broncos, under head coach Sean Payton, have shown significant improvement, particularly with rookie quarterback Bo Nix at the helm. Nix’s mobility and arm strength have added a new dimension to Denver’s offense.

Defensively, the Broncos boast a formidable pass rush, with players like Nik Bonitto and Jonathan Cooper achieving double-digit sacks. Buffalo’s defense, while solid, will need to account for Denver’s dynamic offensive weapons, including wide receiver Courtland Sutton. The game is expected to be a strategic battle, with both teams looking to exploit the other’s weaknesses. Weather conditions in Buffalo could also play a role, potentially impacting game plans and execution. Overall, this matchup offers an intriguing blend of veteran leadership and emerging talent, setting the stage for an exciting playoff encounter.

Denver Broncos NFL Preview

The Buffalo Bills enter the playoffs with a 13-4 record, securing the second seed in the AFC. Under head coach Sean McDermott, the Bills have developed into one of the league’s most balanced teams. Offensively, quarterback Josh Allen has been exceptional, leading a unit that has consistently put up high point totals. Wide receivers Stefon Diggs and Gabriel Davis provide Allen with reliable targets, contributing to the team’s explosive passing game. The running game, complemented by running back James Cook, adds balance to the offense. Defensively, the Bills are stout, with a secondary led by Tre’Davious White and a pass rush featuring Von Miller. Buffalo’s defense ranks among the top in the league in points allowed, showcasing their ability to stifle opposing offenses. Special teams, anchored by kicker Tyler Bass, have been reliable throughout the season. The Bills’ home-field advantage at Highmark Stadium has been significant, with the team covering the spread in six of their last seven home games. As they prepare to face the Broncos, the Bills will look to leverage their balanced attack and home-field advantage to advance further in the playoffs.

The Denver Broncos are set to face the Buffalo Bills in an AFC Wild Card matchup on January 12, 2025, at Highmark Stadium in Buffalo. The Bills, boasting a 13-4 record, are favored by 8.5 points, while the Broncos, entering the playoffs for the first time since their 2016 Super Bowl victory, hold a 10-7 record. Denver vs Buffalo AI Prediction: Free NFL Betting Insights for Jan 12. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Buffalo Bills NFL Preview

The Buffalo Bills enter the playoffs with a 13-4 record, securing the second seed in the AFC. Under head coach Sean McDermott, the Bills have developed into one of the league’s most balanced teams. Offensively, quarterback Josh Allen has been exceptional, leading a unit that has consistently put up high point totals. Wide receivers Stefon Diggs and Gabriel Davis provide Allen with reliable targets, contributing to the team’s explosive passing game. The running game, complemented by running back James Cook, adds balance to the offense. Defensively, the Bills are stout, with a secondary led by Tre’Davious White and a pass rush featuring Von Miller. Buffalo’s defense ranks among the top in the league in points allowed, showcasing their ability to stifle opposing offenses. Special teams, anchored by kicker Tyler Bass, have been reliable throughout the season. The Bills’ home-field advantage at Highmark Stadium has been significant, with the team covering the spread in six of their last seven home games. As they prepare to face the Broncos, the Bills will look to leverage their balanced attack and home-field advantage to advance further in the playoffs.

Denver vs. Buffalo Prop Picks (AI)

Remi is pouring through mountains of data on each line. In fact, anytime the Broncos and Bills play there’s always several intriguing trends to key in on. Not to mention games played at Highmark Stadium in Jan rarely follow normal, predictable betting trends.
Remi's searched hard and found the perfect prop bet for this game: WR Amari Cooper Over 3.5 Targets

Denver vs. Buffalo Prediction (AI)

Remi Robot Icon

Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every facet between the Broncos and Bills and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.

Remi has been most watching on the linear correlation of factor emotional bettors regularly put on Denver’s strength factors between a Broncos team going up against a possibly tired Bills team. In reality, the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Denver vs Buffalo picks, computer picks Broncos vs Bills, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NFL 10/20 HOU@SEA UNLOCK THIS PICK 5 INTEL Locked INTEL
NFL 10/20 TB@DET UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/20 TB@DET UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/20 TB@DET UNLOCK THIS PICK 1 INTEL Locked INTEL
NFL 10/20 HOU@SEA UNLOCK THIS PICK 0 INTEL Locked INTEL
NFL 10/20 TB@DET UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Broncos Betting Trends

The Broncos have demonstrated resilience against the spread (ATS) this season. Notably, they have covered the spread in four of their last five games, indicating a strong finish to the regular season. On the road, Denver has been competitive, achieving a 3-2 ATS record in their last five away games. This suggests that the Broncos have the capability to perform well, even in challenging environments.

Bills Betting Trends

The Bills have been formidable ATS, particularly at home. They have covered the spread in six of their last seven games at Highmark Stadium, showcasing their dominance on home turf. Overall, Buffalo holds a 5-2 ATS record in their last seven games, reflecting consistent performance against betting expectations.

Broncos vs. Bills Matchup Trends

An interesting ATS statistic for this matchup is the Bills’ recent success against the Broncos. Buffalo has covered the spread in three of their last four meetings with Denver. This trend may influence betting perspectives, highlighting the Bills’ historical advantage in this pairing.

Denver vs. Buffalo Game Info

Denver vs Buffalo starts on January 12, 2025 at 2:00 PM EST.

Venue: Highmark Stadium.

Spread: Buffalo -8.5
Moneyline: Denver +346, Buffalo -446
Over/Under: 47

Denver: (10-7)  |  Buffalo: (13-4)

Remi's searched hard and found the perfect prop bet for this game: WR Amari Cooper Over 3.5 Targets. Prices move—always shop for the best number.

An interesting ATS statistic for this matchup is the Bills’ recent success against the Broncos. Buffalo has covered the spread in three of their last four meetings with Denver. This trend may influence betting perspectives, highlighting the Bills’ historical advantage in this pairing.

DEN trend: The Broncos have demonstrated resilience against the spread (ATS) this season. Notably, they have covered the spread in four of their last five games, indicating a strong finish to the regular season. On the road, Denver has been competitive, achieving a 3-2 ATS record in their last five away games. This suggests that the Broncos have the capability to perform well, even in challenging environments.

BUF trend: The Bills have been formidable ATS, particularly at home. They have covered the spread in six of their last seven games at Highmark Stadium, showcasing their dominance on home turf. Overall, Buffalo holds a 5-2 ATS record in their last seven games, reflecting consistent performance against betting expectations.

See our latest NFL picks and odds pages for 2025 to compare prices before you bet.

Denver vs. Buffalo Odds

AI algorithm Remi is pouring through tons of data points on each line. In fact, anytime the Denver vs Buffalo trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme altitude almost always follow normal, predictable betting trends.

Denver vs Buffalo Opening Odds

DEN Moneyline: +346
BUF Moneyline: -446
DEN Spread: +8.5
BUF Spread: -8.5
Over/Under: 47

Denver vs Buffalo Live Odds

Games PTS ML SPR O/U
Oct 23, 2025 8:15PM EDT
Minnesota Vikings
Los Angeles Chargers
10/23/25 8:15PM
Vikings
Chargers
+152
-180
+3 (-102)
-3 (-120)
O 44.5 (-112)
U 44.5 (-108)
Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
+290
-360
+7 (-114)
-7 (-106)
O 40.5 (-105)
U 40.5 (-115)
Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
-370
+295
-7.5 (-102)
+7.5 (-120)
O 46.5 (-105)
U 46.5 (-115)
Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
+245
-300
+6.5 (-110)
-6.5 (-110)
O 43.5 (-115)
U 43.5 (-105)
Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
+265
-330
+6.5 (-106)
-6.5 (-114)
O 50.5 (-105)
U 50.5 (-115)
Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
+285
-355
+7 (-108)
-7 (-112)
O 43.5 (-105)
U 43.5 (-115)
Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
-102
-118
+1.5 (-115)
-1.5 (-105)
O 41.5 (-110)
U 41.5 (-110)
Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
+280
-350
+7.5 (-122)
-7.5 (+100)
O 44.5 (-114)
U 44.5 (-106)
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
-225
+188
-4.5 (-106)
+4.5 (-114)
O 46.5 (-114)
U 46.5 (-106)
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
+146
-174
+3.5 (-118)
-3.5 (-104)
O 50.5 (-110)
U 50.5 (-110)
Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
+750
-1200
+14.5 (-118)
-14.5 (-104)
O 46.5 (-114)
U 46.5 (-106)
Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
-176
+148
-3.5 (-104)
+3.5 (-118)
O 44.5 (-115)
U 44.5 (-105)
Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
+430
-590
+10.5 (-110)
-10.5 (-110)
O 47.5 (-110)
U 47.5 (-110)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Denver Broncos vs. Buffalo Bills on January 12, 2025 at Highmark Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS
HOU@BAL HOU -125 58.5% 7 WIN
DET@CIN DET -10 55.6% 5 WIN
DAL@NYJ NYJ +1.5 53.7% 3 LOSS
TB@SEA TB +3.5 54.9% 4 WIN
TEN@ARI ARI -7 (BUY 0.5) 54.9% 4 LOSS
DEN@PHI DEN +4.5 57.5% 7 WIN
MIA@CAR TETAIROA MCMILLAN OVER 58.5 RECV YDS 54.5% 4 WIN
LV@IND ASHTON JEANTY UNDER 67.5 RUSH YDS 54.4% 4 WIN
SF@LAR DEMARCUS ROBINSON OVER 29.5 RECV YDS 55.7% 5 WIN
NYJ@MIA NYJ +3 53.8 3 LOSS
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS
TEN@HOU TEN +7.5 57.9% 7 LOSS
LAC@NYG LAC -6 57.3% 7 LOSS
NO@BUF UNDER 48.5 55.1% 3 LOSS
GB@DAL JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS 55.5% 5 LOSS
CAR@NE DRAKE MAYE TO THROW AN INT 56.6% 6 LOSS
SEA@ARI SEA -125 57.7% 6 WIN
SEA@ARI KYLER MURRAY TO THROW AN INT 56.6% 6 WIN
DET@BAL JAHMYR GIBBS OVER 0.5 RUSH TDS 55.8% 5 WIN
DAL@CHI DAL -120 58.7% 6 LOSS
PIT@NE PIT -116 60.1% 6 WIN
ATL@CAR ATL -4.5 55.4% 5 LOSS
LV@WAS LV +3 54.3% 4 LOSS