Lions vs. 49ers
Prediction, Odds & Props
Dec 30 | NFL AI Picks

Updated: 2024-12-23T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Detroit Lions (13-2) will face the San Francisco 49ers (6-9) at Levi’s Stadium on Monday, December 30, 2024, at 5:15 PM PST. This Week 17 matchup holds significant implications for the Lions, who are vying to secure the top seed in the NFC, while the 49ers, eliminated from playoff contention, aim to play spoiler and end their season on a positive note.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Dec 30, 2024

Start Time: 9:15 PM EST​

Venue: Levi's Stadium​

49ers Record: (6-9)

Lions Record: (13-2)

OPENING ODDS

DET Moneyline: -180

SF Moneyline: +151

DET Spread: -3.5

SF Spread: +3.5

Over/Under: 50.5

DET
Betting Trends

  • The Lions have been impressive against the spread (ATS) this season, boasting a 10-5 record. Their recent performances include a commanding 34-17 victory over the Chicago Bears, where they covered the spread as favorites. Detroit’s consistent offensive output and solid defense have contributed to their strong ATS performance throughout the season.

SF
Betting Trends

  • Conversely, the 49ers have struggled ATS, holding a 5-10 record. In their recent 29-17 loss to the Miami Dolphins, San Francisco failed to cover the spread, continuing a trend of underwhelming performances both on the field and for bettors. Injuries and inconsistent play have plagued the 49ers, impacting their ability to meet expectations.

MATCHUP TRENDS

  • An interesting ATS statistic to consider is the Lions’ success as road favorites this season, where they have covered the spread in three out of four games. This trend suggests that Detroit has been reliable when favored away from home, which could influence betting decisions for this matchup.

DET vs. SF
Best Prop Bet

  • Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.

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Detroit vs San Francisco Prediction & Odds:
Free NFL Betting Insights for 12/30/24

The Week 17 Monday Night Football clash between the Detroit Lions and the San Francisco 49ers presents a game with contrasting narratives. The Lions, under head coach Dan Campbell, have enjoyed a stellar season, currently holding a 13-2 record and leading the NFC North. Their high-powered offense, led by quarterback Jared Goff, has been a driving force behind their success. Goff has thrown for over 3,700 yards and 30 touchdowns, efficiently distributing the ball to a talented receiving corps that includes Amon-Ra St. Brown and Jameson Williams. The ground game, featuring running backs D’Andre Swift and David Montgomery, provides balance, making Detroit’s offense multifaceted and challenging to defend. Defensively, the Lions have shown significant improvement compared to previous seasons. Their pass rush, anchored by edge rusher Aidan Hutchinson, has been effective in disrupting opposing quarterbacks.

The secondary, led by cornerback Jeff Okudah, has been opportunistic, contributing to a positive turnover differential that has been pivotal in close games. On the other side, the 49ers have had a disappointing season, sitting at 6-9 and out of playoff contention. Injuries to key players, including defensive linemen Javon Hargrave and Eric Armstead, have hampered their performance. The offense, led by quarterback Brock Purdy, has struggled with consistency, particularly in the passing game. While tight end George Kittle remains a reliable target, the lack of a consistent deep threat has limited the offense’s explosiveness. The running game, featuring Christian McCaffrey, has been a bright spot, but without a balanced attack, defenses have been able to focus on containing the run. Defensively, the 49ers have faced challenges, particularly with their Wide-9 scheme, which has been criticized for its ineffectiveness this season. Analysts have noted that teams are exploiting this alignment, especially targeting defensive end Nick Bosa in the wide set. Injuries to key defensive linemen have further exacerbated these issues, leading to vulnerabilities against both the run and the pass. Special teams could play a crucial role in this matchup. The Lions’ kicker, Riley Patterson, has been reliable, while the 49ers have had some inconsistencies in their kicking game. Field position and the ability to convert scoring opportunities will be essential, especially in a game where the Lions are looking to secure the No. 1 seed in the NFC. In summary, this game features a Lions team with much at stake, aiming to maintain momentum heading into the playoffs, against a 49ers squad playing for pride and evaluating talent for the future. Detroit’s balanced offense and improved defense make them the favorites, but San Francisco’s potential to disrupt plans should not be underestimated. Fans can anticipate a competitive game under the lights at Levi’s Stadium.

Detroit Lions NFL Preview

The Detroit Lions come into Week 17 with a 13-2 record, leading the NFC North and on the verge of clinching the top seed in the NFC playoffs. Under the guidance of head coach Dan Campbell, the Lions have emerged as one of the most balanced and formidable teams in the league, combining a high-powered offense with an improving defense. Offensively, quarterback Jared Goff has been the driving force behind the Lions’ success. Goff has thrown for over 3,700 yards and 30 touchdowns, demonstrating precision and confidence in leading the offense. His connection with wide receiver Amon-Ra St. Brown has been particularly impactful, with St. Brown excelling as both a possession receiver and a downfield threat. Second-year receiver Jameson Williams has added a vertical element to the passing game, complementing St. Brown and creating additional challenges for defenses. The Lions’ ground game, led by D’Andre Swift and David Montgomery, provides a dynamic and balanced attack. Swift’s ability to break runs to the outside and contribute as a receiver out of the backfield pairs well with Montgomery’s physical, between-the-tackles running style. The offensive line, anchored by Penei Sewell and Frank Ragnow, has been one of the league’s best, excelling in both pass protection and run blocking. Defensively, the Lions have made significant strides, with edge rusher Aidan Hutchinson leading the way. Hutchinson has been a force off the edge, tallying double-digit sacks and consistently applying pressure on opposing quarterbacks. The interior of the defensive line has also been stout against the run, while the linebacking corps, led by Alex Anzalone, has provided stability in both run defense and coverage. The secondary, featuring cornerback Jeff Okudah, has shown improvement, though it remains a work in progress. Okudah’s ability to shadow top receivers has been valuable, but the unit as a whole has struggled at times against elite passing attacks. The Lions’ opportunistic defense has been effective in creating turnovers, helping to swing momentum in critical moments. Special teams have been a strength for Detroit, with kicker Riley Patterson delivering reliable performances and punter Jack Fox excelling in flipping field position. The return game has also been effective, occasionally setting up the offense with favorable starting field positions. Against the 49ers, the Lions will look to exploit San Francisco’s defensive vulnerabilities, particularly targeting the weaknesses in their Wide-9 scheme. Establishing the run early with Swift and Montgomery will be key to setting up play-action opportunities for Goff to connect with his receivers. Defensively, Detroit must focus on containing Christian McCaffrey and forcing Brock Purdy into mistakes by applying consistent pressure. With the No. 1 seed on the line, the Lions are motivated to deliver a strong performance. A win would solidify their position as the team to beat in the NFC and provide momentum heading into the playoffs. Expect Detroit to bring their best effort in this high-stakes matchup at Levi’s Stadium.

The Detroit Lions (13-2) will face the San Francisco 49ers (6-9) at Levi’s Stadium on Monday, December 30, 2024, at 5:15 PM PST. This Week 17 matchup holds significant implications for the Lions, who are vying to secure the top seed in the NFC, while the 49ers, eliminated from playoff contention, aim to play spoiler and end their season on a positive note. Detroit vs San Francisco AI Prediction: Free NFL Betting Insights for Dec 30. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Francisco 49ers NFL Preview

The San Francisco 49ers enter Week 17 with a 6-9 record, marking a season that has fallen short of expectations. Under head coach Kyle Shanahan, the team has faced numerous challenges, including a series of injuries to key players and inconsistencies on both sides of the ball. As they prepare to host the Detroit Lions, the 49ers aim to finish the season strong and build momentum for the future. Offensively, the 49ers have been led by quarterback Brock Purdy, who has shown flashes of potential but has also experienced typical growing pains associated with a young signal-caller. Purdy has passed for over 2,800 yards and 18 touchdowns but has also been prone to turnovers, with 12 interceptions on the season. Tight end George Kittle remains a cornerstone of the offense, leading the team in receptions and receiving yards, providing a reliable target in both intermediate and deep routes. The running game, anchored by Christian McCaffrey, has been a consistent positive, with McCaffrey accumulating over 1,200 rushing yards and 10 touchdowns, showcasing his versatility as both a runner and receiver out of the backfield. The offensive line has faced its share of challenges, particularly with injuries that have led to a lack of continuity. The recent signing of offensive lineman Charlie Heck aims to address some of these issues, providing additional depth and experience. Protecting Purdy and creating running lanes for McCaffrey will be crucial against a Lions defense known for its aggressive pass rush. Defensively, the 49ers have struggled, particularly with their implementation of the Wide -9 scheme, which has been exploited by opposing offenses throughout the season. Despite the presence of elite talent like Nick Bosa, the defensive line has underperformed, largely due to injuries to key players such as Javon Hargrave and Eric Armstead. Teams have successfully targeted the gaps created by the wide alignments, making it difficult for the 49ers to consistently stop the run and pressure quarterbacks. The secondary, led by veteran safety Talanoa Hufanga, has been inconsistent. Hufanga has provided standout moments with his ball-hawking abilities, but the overall unit has struggled with communication and coverage breakdowns, leading to big plays against them. The linebacking corps, headlined by Fred Warner, remains a strength, with Warner’s leadership and ability to cover sideline-to-sideline continuing to shine despite the team’s struggles. Special teams have been a point of inconsistency for the 49ers. Kicker Jake Moody has faced challenges in critical situations, missing a few key field goals that have cost the team in close games. The return game, while occasionally providing sparks, has not been a consistent source of field position advantage. Heading into this game against the Lions, the 49ers will need to focus on their strengths, particularly utilizing Christian McCaffrey in a variety of roles to keep Detroit’s defense off balance. Brock Purdy must make quick decisions to avoid turnovers, especially against a Lions defense that thrives on creating pressure. Defensively, limiting Jared Goff’s effectiveness and finding ways to disrupt the timing of Detroit’s receivers will be essential to slowing down their potent offense. Although the playoffs are out of reach, this game presents an opportunity for the 49ers to end their season on a high note and evaluate younger players for the future. Competing against a top-tier team like the Lions provides a valuable test of the roster’s depth and potential heading into the offseason.

Detroit vs. San Francisco Prop Picks (AI)

AI algorithm Remi is pouring through tons of datapoints on each team. In fact, anytime the Lions and 49ers play there’s always several intriguing trends to key in on. Not to mention games played at Levi's Stadium in Dec can often follow normal, predictable betting trends.
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.

Detroit vs. San Francisco Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over tons of data from every angle between the Lions and 49ers and using recursive machine learning and industry leading AI to examine the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most keyed in on the growing emphasis knucklehead sportsbettors tend to put on Detroit’s strength factors between a Lions team going up against a possibly unhealthy 49ers team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Detroit vs San Francisco picks, computer picks Lions vs 49ers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Lions Betting Trends

The Lions have been impressive against the spread (ATS) this season, boasting a 10-5 record. Their recent performances include a commanding 34-17 victory over the Chicago Bears, where they covered the spread as favorites. Detroit’s consistent offensive output and solid defense have contributed to their strong ATS performance throughout the season.

49ers Betting Trends

Conversely, the 49ers have struggled ATS, holding a 5-10 record. In their recent 29-17 loss to the Miami Dolphins, San Francisco failed to cover the spread, continuing a trend of underwhelming performances both on the field and for bettors. Injuries and inconsistent play have plagued the 49ers, impacting their ability to meet expectations.

Lions vs. 49ers Matchup Trends

An interesting ATS statistic to consider is the Lions’ success as road favorites this season, where they have covered the spread in three out of four games. This trend suggests that Detroit has been reliable when favored away from home, which could influence betting decisions for this matchup.

Detroit vs. San Francisco Game Info

Detroit vs San Francisco starts on December 30, 2024 at 9:15 PM EST.

Spread: San Francisco +3.5
Moneyline: Detroit -180, San Francisco +151
Over/Under: 50.5

Detroit: (13-2)  |  San Francisco: (6-9)

Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.

An interesting ATS statistic to consider is the Lions’ success as road favorites this season, where they have covered the spread in three out of four games. This trend suggests that Detroit has been reliable when favored away from home, which could influence betting decisions for this matchup.

DET trend: The Lions have been impressive against the spread (ATS) this season, boasting a 10-5 record. Their recent performances include a commanding 34-17 victory over the Chicago Bears, where they covered the spread as favorites. Detroit’s consistent offensive output and solid defense have contributed to their strong ATS performance throughout the season.

SF trend: Conversely, the 49ers have struggled ATS, holding a 5-10 record. In their recent 29-17 loss to the Miami Dolphins, San Francisco failed to cover the spread, continuing a trend of underwhelming performances both on the field and for bettors. Injuries and inconsistent play have plagued the 49ers, impacting their ability to meet expectations.

See our latest NFL picks and odds pages for 2024 to compare prices before you bet.

Detroit vs. San Francisco Odds

Remi is pouring through mountains of data points on each player. In fact, anytime the Detroit vs San Francisco trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable betting trends.

Detroit vs San Francisco Opening Odds

DET Moneyline: -180
SF Moneyline: +151
DET Spread: -3.5
SF Spread: +3.5
Over/Under: 50.5

Detroit vs San Francisco Live Odds

Games PTS ML SPR O/U
Sep 28, 2025 9:31AM EDT
Minnesota Vikings
Pittsburgh Steelers
9/28/25 9:31AM
Vikings
Steelers
-140
+115
-2.5 (-115)
+2.5 (-105)
O 41 (-110)
U 41 (-110)
Sep 28, 2025 1:00PM EDT
Cleveland Browns
Detroit Lions
9/28/25 1PM
Browns
Lions
+400
-550
+10 (-110)
-10 (-110)
O 44.5 (-105)
U 44.5 (-115)
Sep 28, 2025 1:00PM EDT
Los Angeles Chargers
New York Giants
9/28/25 1PM
Chargers
Giants
-285
+230
-6.5 (-105)
+6.5 (-115)
O 44 (-110)
U 44 (-110)
Sep 28, 2025 1:01PM EDT
Tennessee Titans
Houston Texans
9/28/25 1:01PM
Titans
Texans
+300
-375
+7 (-105)
-7 (-115)
O 39 (-110)
U 39 (-110)
Sep 28, 2025 1:01PM EDT
Philadelphia Eagles
Tampa Bay Buccaneers
9/28/25 1:01PM
Eagles
Buccaneers
-190
+160
-3.5 (-105)
+3.5 (-115)
O 44 (-110)
U 44 (-110)
Sep 28, 2025 1:01PM EDT
Washington Commanders
Atlanta Falcons
9/28/25 1:01PM
Commanders
Falcons
+110
-130
+2 (-110)
-2 (-110)
O 43.5 (-110)
U 43.5 (-110)
Sep 28, 2025 1:01PM EDT
New Orleans Saints
Buffalo Bills
9/28/25 1:01PM
Saints
Bills
+800
-1300
+15 (-110)
-15 (-110)
O 48 (-110)
U 48 (-110)
Sep 28, 2025 1:01PM EDT
Carolina Panthers
New England Patriots
9/28/25 1:01PM
Panthers
Patriots
+200
-250
+5.5 (-110)
-5.5 (-110)
O 43 (-110)
U 43 (-110)
Sep 28, 2025 4:06PM EDT
Jacksonville Jaguars
San Francisco 49ers
9/28/25 4:06PM
Jaguars
49ers
+150
-180
+3.5 (-115)
-3.5 (-105)
O 46.5 (-110)
U 46.5 (-110)
Sep 28, 2025 4:06PM EDT
Indianapolis Colts
Los Angeles Rams
9/28/25 4:06PM
Colts
Rams
+160
-190
+3.5 (-110)
-3.5 (-110)
O 49.5 (-110)
U 49.5 (-110)
Sep 28, 2025 4:25PM EDT
Baltimore Ravens
Kansas City Chiefs
9/28/25 4:25PM
Ravens
Chiefs
-150
+125
-2.5 (-120)
+2.5 (+100)
O 48.5 (-110)
U 48.5 (-110)
Sep 28, 2025 4:26PM EDT
Chicago Bears
Las Vegas Raiders
9/28/25 4:26PM
Bears
Raiders
+100
-120
+1 (-110)
-1 (-110)
O 48 (-110)
U 48 (-110)
Sep 28, 2025 8:21PM EDT
Green Bay Packers
Dallas Cowboys
9/28/25 8:21PM
Packers
Cowboys
-325
+250
-7 (-105)
+7 (-115)
O 47 (-110)
U 47 (-110)
Sep 29, 2025 7:15PM EDT
New York Jets
Miami Dolphins
9/29/25 7:15PM
Jets
Dolphins
+125
-150
+3 (-115)
-3 (-105)
O 44.5 (-110)
U 44.5 (-110)
Sep 29, 2025 8:15PM EDT
Cincinnati Bengals
Denver Broncos
9/29/25 8:15PM
Bengals
Broncos
+310
-400
+7.5 (-110)
-7.5 (-110)
O 44 (-110)
U 44 (-110)
Oct 2, 2025 8:16PM EDT
San Francisco 49ers
Los Angeles Rams
10/2/25 8:16PM
49ers
Rams
+134
-158
+3 (-105)
-3 (-115)
O 47 (-110)
U 47 (-110)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Detroit Lions vs. San Francisco 49ers on December 30, 2024 at Levi's Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
SEA@ARI SEA -125 57.7% 6 WIN
SEA@ARI KYLER MURRAY TO THROW AN INT 56.6% 6 WIN
DET@BAL JAHMYR GIBBS OVER 0.5 RUSH TDS 55.8% 5 WIN
DAL@CHI DAL -120 58.7% 6 LOSS
PIT@NE PIT -116 60.1% 6 WIN
ATL@CAR ATL -4.5 55.4% 5 LOSS
LV@WAS LV +3 54.3% 4 LOSS
GB@CLE GB -7 54.3% 4 LOSS
ARI@SF ARI +3 57.7% 6 WIN
KC@NYG PATRICK MAHOMES OVER 230.5 PASS YDS 54.7% 4 WIN
GB@CLE JOE FLACCO OVER 37.5 PASS ATT 56.6% 6 LOSS
MIA@BUF TYREEK HILL OVER 5.5 TOTAL RECEPTIONS 56.8% 6 LOSS
LAC@LV LAC -3 54.9% 4 WIN
TB@HOU BAKER MAYFIELD OVER 1.5 PASS TDS 54.4% 4 WIN
CHI@DET DET -6.5 54.3% 4 WIN
DEN@IND DEN -118 60.1% 10 LOSS
PHI@KC PHI -115 56.7% 6 WIN
SF@NO SF -3 58.8% 8 WIN
SEA@PIT OVER 40 54.9% 4 WIN
CAR@ARI BRYCE YOUNG INTERCEPTIONS UNDER 0.5 56.4% 6 LOSS
DEN@IND JOSH DOWNS RECEPTIONS OVER 3.5 54.7% 4 WIN
ATL@MIN BIJAN ROBINSON RUSH + REC YDS OVER 94.5 53.4% 3 WIN
WAS@GB WAS +3.5 56.5% 6 LOSS
WAS@GB JORDAN LOVE OVER 5.5 RUSH YDS 54.7% 4 WIN
MIN@CHI CALEB WILLIAMS OVER 219.5 PASS YDS 53.4% 3 LOSS
TEN@DEN DEN -8.5 55.3% 5 LOSS
SF@SEA SF -115 54.6% 4 WIN
SF@SEA KENNETH WALKER III UNDER 79.5 RUSH+REC YDS 54.6% 4 WIN
CAR@JAC TANK BIGSBY OVER 10.5 RUSH ATT 56.1% 6 LOSS
KC@LAC JUSTIN HERBERT UNDER 0.5 INT 54.1% 3 WIN
DAL@PHI GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS 54.1% 4 LOSS
KC@PHI JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS 53.90% 5 WIN
KC@PHI DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS 54.40% 6 WIN
KC@PHI PATRICK MAHOMES UNDER 68.3% PASS COMP 55.00% 8 WIN
KC@PHI JALEN HURTS LONGEST RUSH OVER 12.5 YDS 55.60% 8 WIN
BUF@KC DALTON KINCAID OVER 29.5 RECV YDS 55.10% 8 LOSS
WAS@PHI DEVONTA SMITH OVER 3.5 RECEPTIONS 55.80% 8 WIN
BUF@KC JAMES COOK ANYTIME TD 53.00% 5 WIN
LAR@PHI SAQUON BARKLEY UNDER 128 RUSH + REC YDS 53.20% 5 LOSS
BAL@BUF LAMAR JACKSON OVER 54.5 RUSH YDS 54.50% 6 LOSS
HOU@KC C.J. STROUD RUSH YDS UNDER 14.5 53.10% 5 LOSS
WAS@DET JAMESON WILLIAMS RUSH YDS OVER 1.5 53.30% 5 WIN
WAS@DET JARED GOFF PASS COMP % UNDER 72.3 54.30% 6 WIN
MIN@LAR COOPER KUPP ANYTIME TOUCHDOWN 52.60% 3 LOSS
MIN@LAR MATTHEW STAFFORD OVER 21.5 PASS COMP 54.10% 6 LOSS
WAS@TB BRIAN ROBINSON JR OVER 1.5 REC TARGETS 53.50% 5 WIN
WAS@TB BAKER MAYFIELD UNDER 33.5 PASS ATT 54.90% 6 WIN
GB@PHI JALEN HURTS OVER 67.1 PASS COMP PERCENTAGE 54.60% 6 LOSS
LAC@HOU J.K. DOBBINS ANYTIME TD 52.80% 3 LOSS
LAC@HOU LAC -2.5 53.40% 3 LOSS
LAC@HOU JUSTIN HERBERT OVER 19.5 RUSH YDS 53.40% 5 LOSS