Lions vs. 49ers
Prediction, Odds & Props
Dec 30 | NFL AI Picks
Updated: 2024-12-23T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Detroit Lions (13-2) will face the San Francisco 49ers (6-9) at Levi’s Stadium on Monday, December 30, 2024, at 5:15 PM PST. This Week 17 matchup holds significant implications for the Lions, who are vying to secure the top seed in the NFC, while the 49ers, eliminated from playoff contention, aim to play spoiler and end their season on a positive note.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Dec 30, 2024
Start Time: 9:15 PM EST
Venue: Levi's Stadium
49ers Record: (6-9)
Lions Record: (13-2)
OPENING ODDS
DET Moneyline: -180
SF Moneyline: +151
DET Spread: -3.5
SF Spread: +3.5
Over/Under: 50.5
DET
Betting Trends
- The Lions have been impressive against the spread (ATS) this season, boasting a 10-5 record. Their recent performances include a commanding 34-17 victory over the Chicago Bears, where they covered the spread as favorites. Detroit’s consistent offensive output and solid defense have contributed to their strong ATS performance throughout the season.
SF
Betting Trends
- Conversely, the 49ers have struggled ATS, holding a 5-10 record. In their recent 29-17 loss to the Miami Dolphins, San Francisco failed to cover the spread, continuing a trend of underwhelming performances both on the field and for bettors. Injuries and inconsistent play have plagued the 49ers, impacting their ability to meet expectations.
MATCHUP TRENDS
- An interesting ATS statistic to consider is the Lions’ success as road favorites this season, where they have covered the spread in three out of four games. This trend suggests that Detroit has been reliable when favored away from home, which could influence betting decisions for this matchup.
DET vs. SF
Best Prop Bet
- Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.
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Detroit vs San Francisco Prediction & Odds:
Free NFL Betting Insights for 12/30/24
The secondary, led by cornerback Jeff Okudah, has been opportunistic, contributing to a positive turnover differential that has been pivotal in close games. On the other side, the 49ers have had a disappointing season, sitting at 6-9 and out of playoff contention. Injuries to key players, including defensive linemen Javon Hargrave and Eric Armstead, have hampered their performance. The offense, led by quarterback Brock Purdy, has struggled with consistency, particularly in the passing game. While tight end George Kittle remains a reliable target, the lack of a consistent deep threat has limited the offense’s explosiveness. The running game, featuring Christian McCaffrey, has been a bright spot, but without a balanced attack, defenses have been able to focus on containing the run. Defensively, the 49ers have faced challenges, particularly with their Wide-9 scheme, which has been criticized for its ineffectiveness this season. Analysts have noted that teams are exploiting this alignment, especially targeting defensive end Nick Bosa in the wide set. Injuries to key defensive linemen have further exacerbated these issues, leading to vulnerabilities against both the run and the pass. Special teams could play a crucial role in this matchup. The Lions’ kicker, Riley Patterson, has been reliable, while the 49ers have had some inconsistencies in their kicking game. Field position and the ability to convert scoring opportunities will be essential, especially in a game where the Lions are looking to secure the No. 1 seed in the NFC. In summary, this game features a Lions team with much at stake, aiming to maintain momentum heading into the playoffs, against a 49ers squad playing for pride and evaluating talent for the future. Detroit’s balanced offense and improved defense make them the favorites, but San Francisco’s potential to disrupt plans should not be underestimated. Fans can anticipate a competitive game under the lights at Levi’s Stadium.
#DetroitPeopleMovers > Chicago's L pic.twitter.com/8h30mpBqGj
— Detroit Lions (@Lions) December 27, 2024
Detroit Lions NFL Preview
The Detroit Lions come into Week 17 with a 13-2 record, leading the NFC North and on the verge of clinching the top seed in the NFC playoffs. Under the guidance of head coach Dan Campbell, the Lions have emerged as one of the most balanced and formidable teams in the league, combining a high-powered offense with an improving defense. Offensively, quarterback Jared Goff has been the driving force behind the Lions’ success. Goff has thrown for over 3,700 yards and 30 touchdowns, demonstrating precision and confidence in leading the offense. His connection with wide receiver Amon-Ra St. Brown has been particularly impactful, with St. Brown excelling as both a possession receiver and a downfield threat. Second-year receiver Jameson Williams has added a vertical element to the passing game, complementing St. Brown and creating additional challenges for defenses. The Lions’ ground game, led by D’Andre Swift and David Montgomery, provides a dynamic and balanced attack. Swift’s ability to break runs to the outside and contribute as a receiver out of the backfield pairs well with Montgomery’s physical, between-the-tackles running style. The offensive line, anchored by Penei Sewell and Frank Ragnow, has been one of the league’s best, excelling in both pass protection and run blocking. Defensively, the Lions have made significant strides, with edge rusher Aidan Hutchinson leading the way. Hutchinson has been a force off the edge, tallying double-digit sacks and consistently applying pressure on opposing quarterbacks. The interior of the defensive line has also been stout against the run, while the linebacking corps, led by Alex Anzalone, has provided stability in both run defense and coverage. The secondary, featuring cornerback Jeff Okudah, has shown improvement, though it remains a work in progress. Okudah’s ability to shadow top receivers has been valuable, but the unit as a whole has struggled at times against elite passing attacks. The Lions’ opportunistic defense has been effective in creating turnovers, helping to swing momentum in critical moments. Special teams have been a strength for Detroit, with kicker Riley Patterson delivering reliable performances and punter Jack Fox excelling in flipping field position. The return game has also been effective, occasionally setting up the offense with favorable starting field positions. Against the 49ers, the Lions will look to exploit San Francisco’s defensive vulnerabilities, particularly targeting the weaknesses in their Wide-9 scheme. Establishing the run early with Swift and Montgomery will be key to setting up play-action opportunities for Goff to connect with his receivers. Defensively, Detroit must focus on containing Christian McCaffrey and forcing Brock Purdy into mistakes by applying consistent pressure. With the No. 1 seed on the line, the Lions are motivated to deliver a strong performance. A win would solidify their position as the team to beat in the NFC and provide momentum heading into the playoffs. Expect Detroit to bring their best effort in this high-stakes matchup at Levi’s Stadium.

Credit: USA TODAY/IMAGN
San Francisco 49ers NFL Preview
The San Francisco 49ers enter Week 17 with a 6-9 record, marking a season that has fallen short of expectations. Under head coach Kyle Shanahan, the team has faced numerous challenges, including a series of injuries to key players and inconsistencies on both sides of the ball. As they prepare to host the Detroit Lions, the 49ers aim to finish the season strong and build momentum for the future. Offensively, the 49ers have been led by quarterback Brock Purdy, who has shown flashes of potential but has also experienced typical growing pains associated with a young signal-caller. Purdy has passed for over 2,800 yards and 18 touchdowns but has also been prone to turnovers, with 12 interceptions on the season. Tight end George Kittle remains a cornerstone of the offense, leading the team in receptions and receiving yards, providing a reliable target in both intermediate and deep routes. The running game, anchored by Christian McCaffrey, has been a consistent positive, with McCaffrey accumulating over 1,200 rushing yards and 10 touchdowns, showcasing his versatility as both a runner and receiver out of the backfield. The offensive line has faced its share of challenges, particularly with injuries that have led to a lack of continuity. The recent signing of offensive lineman Charlie Heck aims to address some of these issues, providing additional depth and experience. Protecting Purdy and creating running lanes for McCaffrey will be crucial against a Lions defense known for its aggressive pass rush. Defensively, the 49ers have struggled, particularly with their implementation of the Wide -9 scheme, which has been exploited by opposing offenses throughout the season. Despite the presence of elite talent like Nick Bosa, the defensive line has underperformed, largely due to injuries to key players such as Javon Hargrave and Eric Armstead. Teams have successfully targeted the gaps created by the wide alignments, making it difficult for the 49ers to consistently stop the run and pressure quarterbacks. The secondary, led by veteran safety Talanoa Hufanga, has been inconsistent. Hufanga has provided standout moments with his ball-hawking abilities, but the overall unit has struggled with communication and coverage breakdowns, leading to big plays against them. The linebacking corps, headlined by Fred Warner, remains a strength, with Warner’s leadership and ability to cover sideline-to-sideline continuing to shine despite the team’s struggles. Special teams have been a point of inconsistency for the 49ers. Kicker Jake Moody has faced challenges in critical situations, missing a few key field goals that have cost the team in close games. The return game, while occasionally providing sparks, has not been a consistent source of field position advantage. Heading into this game against the Lions, the 49ers will need to focus on their strengths, particularly utilizing Christian McCaffrey in a variety of roles to keep Detroit’s defense off balance. Brock Purdy must make quick decisions to avoid turnovers, especially against a Lions defense that thrives on creating pressure. Defensively, limiting Jared Goff’s effectiveness and finding ways to disrupt the timing of Detroit’s receivers will be essential to slowing down their potent offense. Although the playoffs are out of reach, this game presents an opportunity for the 49ers to end their season on a high note and evaluate younger players for the future. Competing against a top-tier team like the Lions provides a valuable test of the roster’s depth and potential heading into the offseason.
All the ways to watch and listen to Monday Night Football versus the Lions 👇
— San Francisco 49ers (@49ers) December 27, 2024
Detroit vs. San Francisco Prop Picks (AI)
Detroit vs. San Francisco Prediction (AI)

Remi, our AI sports algorithm, has been pouring over tons of data from every angle between the Lions and 49ers and using recursive machine learning and industry leading AI to examine the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most keyed in on the growing emphasis knucklehead sportsbettors tend to put on Detroit’s strength factors between a Lions team going up against a possibly unhealthy 49ers team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Detroit vs San Francisco picks, computer picks Lions vs 49ers, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Lions Betting Trends
The Lions have been impressive against the spread (ATS) this season, boasting a 10-5 record. Their recent performances include a commanding 34-17 victory over the Chicago Bears, where they covered the spread as favorites. Detroit’s consistent offensive output and solid defense have contributed to their strong ATS performance throughout the season.
49ers Betting Trends
Conversely, the 49ers have struggled ATS, holding a 5-10 record. In their recent 29-17 loss to the Miami Dolphins, San Francisco failed to cover the spread, continuing a trend of underwhelming performances both on the field and for bettors. Injuries and inconsistent play have plagued the 49ers, impacting their ability to meet expectations.
Lions vs. 49ers Matchup Trends
An interesting ATS statistic to consider is the Lions’ success as road favorites this season, where they have covered the spread in three out of four games. This trend suggests that Detroit has been reliable when favored away from home, which could influence betting decisions for this matchup.
Detroit vs. San Francisco Game Info
What time does Detroit vs San Francisco start on December 30, 2024?
Detroit vs San Francisco starts on December 30, 2024 at 9:15 PM EST.
Where is Detroit vs San Francisco being played?
Venue: Levi's Stadium.
What are the opening odds for Detroit vs San Francisco?
Spread: San Francisco +3.5
Moneyline: Detroit -180, San Francisco +151
Over/Under: 50.5
What are the records for Detroit vs San Francisco?
Detroit: (13-2) | San Francisco: (6-9)
What is the AI best bet for Detroit vs San Francisco?
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.
What are Detroit vs San Francisco trending bets?
An interesting ATS statistic to consider is the Lions’ success as road favorites this season, where they have covered the spread in three out of four games. This trend suggests that Detroit has been reliable when favored away from home, which could influence betting decisions for this matchup.
What are Detroit trending bets?
DET trend: The Lions have been impressive against the spread (ATS) this season, boasting a 10-5 record. Their recent performances include a commanding 34-17 victory over the Chicago Bears, where they covered the spread as favorites. Detroit’s consistent offensive output and solid defense have contributed to their strong ATS performance throughout the season.
What are San Francisco trending bets?
SF trend: Conversely, the 49ers have struggled ATS, holding a 5-10 record. In their recent 29-17 loss to the Miami Dolphins, San Francisco failed to cover the spread, continuing a trend of underwhelming performances both on the field and for bettors. Injuries and inconsistent play have plagued the 49ers, impacting their ability to meet expectations.
Where can I find AI Picks for Detroit vs San Francisco?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
Detroit vs. San Francisco Odds
Remi is pouring through mountains of data points on each player. In fact, anytime the Detroit vs San Francisco trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable betting trends.
Detroit vs San Francisco Opening Odds
DET Moneyline:
-180 SF Moneyline: +151
DET Spread: -3.5
SF Spread: +3.5
Over/Under: 50.5
Detroit vs San Francisco Live Odds
Games | PTS | ML | SPR | O/U | |
---|---|---|---|---|---|
Sep 28, 2025 9:31AM EDT
Minnesota Vikings
Pittsburgh Steelers
9/28/25 9:31AM
Vikings
Steelers
|
–
–
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-140
+115
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-2.5 (-115)
+2.5 (-105)
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O 41 (-110)
U 41 (-110)
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Sep 28, 2025 1:00PM EDT
Cleveland Browns
Detroit Lions
9/28/25 1PM
Browns
Lions
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–
–
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+400
-550
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+10 (-110)
-10 (-110)
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O 44.5 (-105)
U 44.5 (-115)
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Sep 28, 2025 1:00PM EDT
Los Angeles Chargers
New York Giants
9/28/25 1PM
Chargers
Giants
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–
–
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-285
+230
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-6.5 (-105)
+6.5 (-115)
|
O 44 (-110)
U 44 (-110)
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Sep 28, 2025 1:01PM EDT
Tennessee Titans
Houston Texans
9/28/25 1:01PM
Titans
Texans
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–
–
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+300
-375
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+7 (-105)
-7 (-115)
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O 39 (-110)
U 39 (-110)
|
|
Sep 28, 2025 1:01PM EDT
Philadelphia Eagles
Tampa Bay Buccaneers
9/28/25 1:01PM
Eagles
Buccaneers
|
–
–
|
-190
+160
|
-3.5 (-105)
+3.5 (-115)
|
O 44 (-110)
U 44 (-110)
|
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Sep 28, 2025 1:01PM EDT
Washington Commanders
Atlanta Falcons
9/28/25 1:01PM
Commanders
Falcons
|
–
–
|
+110
-130
|
+2 (-110)
-2 (-110)
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O 43.5 (-110)
U 43.5 (-110)
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Sep 28, 2025 1:01PM EDT
New Orleans Saints
Buffalo Bills
9/28/25 1:01PM
Saints
Bills
|
–
–
|
+800
-1300
|
+15 (-110)
-15 (-110)
|
O 48 (-110)
U 48 (-110)
|
|
Sep 28, 2025 1:01PM EDT
Carolina Panthers
New England Patriots
9/28/25 1:01PM
Panthers
Patriots
|
–
–
|
+200
-250
|
+5.5 (-110)
-5.5 (-110)
|
O 43 (-110)
U 43 (-110)
|
|
Sep 28, 2025 4:06PM EDT
Jacksonville Jaguars
San Francisco 49ers
9/28/25 4:06PM
Jaguars
49ers
|
–
–
|
+150
-180
|
+3.5 (-115)
-3.5 (-105)
|
O 46.5 (-110)
U 46.5 (-110)
|
|
Sep 28, 2025 4:06PM EDT
Indianapolis Colts
Los Angeles Rams
9/28/25 4:06PM
Colts
Rams
|
–
–
|
+160
-190
|
+3.5 (-110)
-3.5 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
Sep 28, 2025 4:25PM EDT
Baltimore Ravens
Kansas City Chiefs
9/28/25 4:25PM
Ravens
Chiefs
|
–
–
|
-150
+125
|
-2.5 (-120)
+2.5 (+100)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
Sep 28, 2025 4:26PM EDT
Chicago Bears
Las Vegas Raiders
9/28/25 4:26PM
Bears
Raiders
|
–
–
|
+100
-120
|
+1 (-110)
-1 (-110)
|
O 48 (-110)
U 48 (-110)
|
|
Sep 28, 2025 8:21PM EDT
Green Bay Packers
Dallas Cowboys
9/28/25 8:21PM
Packers
Cowboys
|
–
–
|
-325
+250
|
-7 (-105)
+7 (-115)
|
O 47 (-110)
U 47 (-110)
|
|
Sep 29, 2025 7:15PM EDT
New York Jets
Miami Dolphins
9/29/25 7:15PM
Jets
Dolphins
|
–
–
|
+125
-150
|
+3 (-115)
-3 (-105)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
Sep 29, 2025 8:15PM EDT
Cincinnati Bengals
Denver Broncos
9/29/25 8:15PM
Bengals
Broncos
|
–
–
|
+310
-400
|
+7.5 (-110)
-7.5 (-110)
|
O 44 (-110)
U 44 (-110)
|
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Oct 2, 2025 8:16PM EDT
San Francisco 49ers
Los Angeles Rams
10/2/25 8:16PM
49ers
Rams
|
–
–
|
+134
-158
|
+3 (-105)
-3 (-115)
|
O 47 (-110)
U 47 (-110)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Detroit Lions vs. San Francisco 49ers on December 30, 2024 at Levi's Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
PIT@NE | PIT -116 | 60.1% | 6 | WIN |
ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
LV@WAS | LV +3 | 54.3% | 4 | LOSS |
GB@CLE | GB -7 | 54.3% | 4 | LOSS |
ARI@SF | ARI +3 | 57.7% | 6 | WIN |
KC@NYG | PATRICK MAHOMES OVER 230.5 PASS YDS | 54.7% | 4 | WIN |
GB@CLE | JOE FLACCO OVER 37.5 PASS ATT | 56.6% | 6 | LOSS |
MIA@BUF | TYREEK HILL OVER 5.5 TOTAL RECEPTIONS | 56.8% | 6 | LOSS |
LAC@LV | LAC -3 | 54.9% | 4 | WIN |
TB@HOU | BAKER MAYFIELD OVER 1.5 PASS TDS | 54.4% | 4 | WIN |
CHI@DET | DET -6.5 | 54.3% | 4 | WIN |
DEN@IND | DEN -118 | 60.1% | 10 | LOSS |
PHI@KC | PHI -115 | 56.7% | 6 | WIN |
SF@NO | SF -3 | 58.8% | 8 | WIN |
SEA@PIT | OVER 40 | 54.9% | 4 | WIN |
CAR@ARI | BRYCE YOUNG INTERCEPTIONS UNDER 0.5 | 56.4% | 6 | LOSS |
DEN@IND | JOSH DOWNS RECEPTIONS OVER 3.5 | 54.7% | 4 | WIN |
ATL@MIN | BIJAN ROBINSON RUSH + REC YDS OVER 94.5 | 53.4% | 3 | WIN |
WAS@GB | WAS +3.5 | 56.5% | 6 | LOSS |
WAS@GB | JORDAN LOVE OVER 5.5 RUSH YDS | 54.7% | 4 | WIN |
MIN@CHI | CALEB WILLIAMS OVER 219.5 PASS YDS | 53.4% | 3 | LOSS |
TEN@DEN | DEN -8.5 | 55.3% | 5 | LOSS |
SF@SEA | SF -115 | 54.6% | 4 | WIN |
SF@SEA | KENNETH WALKER III UNDER 79.5 RUSH+REC YDS | 54.6% | 4 | WIN |
CAR@JAC | TANK BIGSBY OVER 10.5 RUSH ATT | 56.1% | 6 | LOSS |
KC@LAC | JUSTIN HERBERT UNDER 0.5 INT | 54.1% | 3 | WIN |
DAL@PHI | GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS | 54.1% | 4 | LOSS |
KC@PHI | JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS | 53.90% | 5 | WIN |
KC@PHI | DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS | 54.40% | 6 | WIN |
KC@PHI | PATRICK MAHOMES UNDER 68.3% PASS COMP | 55.00% | 8 | WIN |
KC@PHI | JALEN HURTS LONGEST RUSH OVER 12.5 YDS | 55.60% | 8 | WIN |
BUF@KC | DALTON KINCAID OVER 29.5 RECV YDS | 55.10% | 8 | LOSS |
WAS@PHI | DEVONTA SMITH OVER 3.5 RECEPTIONS | 55.80% | 8 | WIN |
BUF@KC | JAMES COOK ANYTIME TD | 53.00% | 5 | WIN |
LAR@PHI | SAQUON BARKLEY UNDER 128 RUSH + REC YDS | 53.20% | 5 | LOSS |
BAL@BUF | LAMAR JACKSON OVER 54.5 RUSH YDS | 54.50% | 6 | LOSS |
HOU@KC | C.J. STROUD RUSH YDS UNDER 14.5 | 53.10% | 5 | LOSS |
WAS@DET | JAMESON WILLIAMS RUSH YDS OVER 1.5 | 53.30% | 5 | WIN |
WAS@DET | JARED GOFF PASS COMP % UNDER 72.3 | 54.30% | 6 | WIN |
MIN@LAR | COOPER KUPP ANYTIME TOUCHDOWN | 52.60% | 3 | LOSS |
MIN@LAR | MATTHEW STAFFORD OVER 21.5 PASS COMP | 54.10% | 6 | LOSS |
WAS@TB | BRIAN ROBINSON JR OVER 1.5 REC TARGETS | 53.50% | 5 | WIN |
WAS@TB | BAKER MAYFIELD UNDER 33.5 PASS ATT | 54.90% | 6 | WIN |
GB@PHI | JALEN HURTS OVER 67.1 PASS COMP PERCENTAGE | 54.60% | 6 | LOSS |
LAC@HOU | J.K. DOBBINS ANYTIME TD | 52.80% | 3 | LOSS |
LAC@HOU | LAC -2.5 | 53.40% | 3 | LOSS |
LAC@HOU | JUSTIN HERBERT OVER 19.5 RUSH YDS | 53.40% | 5 | LOSS |