Lions vs 49ers Prediction — AI Finds CAN'T MISS NFL Lines & Props (Dec 30)

Updated: 2024-12-23T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Detroit Lions (13-2) will face the San Francisco 49ers (6-9) at Levi’s Stadium on Monday, December 30, 2024, at 5:15 PM PST. This Week 17 matchup holds significant implications for the Lions, who are vying to secure the top seed in the NFC, while the 49ers, eliminated from playoff contention, aim to play spoiler and end their season on a positive note.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Dec 30, 2024

Start Time: 9:15 PM EST​

Venue: Levi's Stadium​

49ers Record: (6-9)

Lions Record: (13-2)

OPENING ODDS

DET Moneyline: -180

SF Moneyline: +151

DET Spread: -3.5

SF Spread: +3.5

Over/Under: 50.5

DET
Betting Trends

  • The Lions have been impressive against the spread (ATS) this season, boasting a 10-5 record. Their recent performances include a commanding 34-17 victory over the Chicago Bears, where they covered the spread as favorites. Detroit’s consistent offensive output and solid defense have contributed to their strong ATS performance throughout the season.

SF
Betting Trends

  • Conversely, the 49ers have struggled ATS, holding a 5-10 record. In their recent 29-17 loss to the Miami Dolphins, San Francisco failed to cover the spread, continuing a trend of underwhelming performances both on the field and for bettors. Injuries and inconsistent play have plagued the 49ers, impacting their ability to meet expectations.

MATCHUP TRENDS

  • An interesting ATS statistic to consider is the Lions’ success as road favorites this season, where they have covered the spread in three out of four games. This trend suggests that Detroit has been reliable when favored away from home, which could influence betting decisions for this matchup.

DET vs. SF
Best Prop Bet

  • Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.

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Detroit vs San Francisco Prediction & Odds:
Free NFL Betting Insights for 12/30/24

The Week 17 Monday Night Football clash between the Detroit Lions and the San Francisco 49ers presents a game with contrasting narratives. The Lions, under head coach Dan Campbell, have enjoyed a stellar season, currently holding a 13-2 record and leading the NFC North. Their high-powered offense, led by quarterback Jared Goff, has been a driving force behind their success. Goff has thrown for over 3,700 yards and 30 touchdowns, efficiently distributing the ball to a talented receiving corps that includes Amon-Ra St. Brown and Jameson Williams. The ground game, featuring running backs D’Andre Swift and David Montgomery, provides balance, making Detroit’s offense multifaceted and challenging to defend. Defensively, the Lions have shown significant improvement compared to previous seasons. Their pass rush, anchored by edge rusher Aidan Hutchinson, has been effective in disrupting opposing quarterbacks.

The secondary, led by cornerback Jeff Okudah, has been opportunistic, contributing to a positive turnover differential that has been pivotal in close games. On the other side, the 49ers have had a disappointing season, sitting at 6-9 and out of playoff contention. Injuries to key players, including defensive linemen Javon Hargrave and Eric Armstead, have hampered their performance. The offense, led by quarterback Brock Purdy, has struggled with consistency, particularly in the passing game. While tight end George Kittle remains a reliable target, the lack of a consistent deep threat has limited the offense’s explosiveness. The running game, featuring Christian McCaffrey, has been a bright spot, but without a balanced attack, defenses have been able to focus on containing the run. Defensively, the 49ers have faced challenges, particularly with their Wide-9 scheme, which has been criticized for its ineffectiveness this season. Analysts have noted that teams are exploiting this alignment, especially targeting defensive end Nick Bosa in the wide set. Injuries to key defensive linemen have further exacerbated these issues, leading to vulnerabilities against both the run and the pass. Special teams could play a crucial role in this matchup. The Lions’ kicker, Riley Patterson, has been reliable, while the 49ers have had some inconsistencies in their kicking game. Field position and the ability to convert scoring opportunities will be essential, especially in a game where the Lions are looking to secure the No. 1 seed in the NFC. In summary, this game features a Lions team with much at stake, aiming to maintain momentum heading into the playoffs, against a 49ers squad playing for pride and evaluating talent for the future. Detroit’s balanced offense and improved defense make them the favorites, but San Francisco’s potential to disrupt plans should not be underestimated. Fans can anticipate a competitive game under the lights at Levi’s Stadium.

Detroit Lions NFL Preview

The Detroit Lions come into Week 17 with a 13-2 record, leading the NFC North and on the verge of clinching the top seed in the NFC playoffs. Under the guidance of head coach Dan Campbell, the Lions have emerged as one of the most balanced and formidable teams in the league, combining a high-powered offense with an improving defense. Offensively, quarterback Jared Goff has been the driving force behind the Lions’ success. Goff has thrown for over 3,700 yards and 30 touchdowns, demonstrating precision and confidence in leading the offense. His connection with wide receiver Amon-Ra St. Brown has been particularly impactful, with St. Brown excelling as both a possession receiver and a downfield threat. Second-year receiver Jameson Williams has added a vertical element to the passing game, complementing St. Brown and creating additional challenges for defenses. The Lions’ ground game, led by D’Andre Swift and David Montgomery, provides a dynamic and balanced attack. Swift’s ability to break runs to the outside and contribute as a receiver out of the backfield pairs well with Montgomery’s physical, between-the-tackles running style. The offensive line, anchored by Penei Sewell and Frank Ragnow, has been one of the league’s best, excelling in both pass protection and run blocking. Defensively, the Lions have made significant strides, with edge rusher Aidan Hutchinson leading the way. Hutchinson has been a force off the edge, tallying double-digit sacks and consistently applying pressure on opposing quarterbacks. The interior of the defensive line has also been stout against the run, while the linebacking corps, led by Alex Anzalone, has provided stability in both run defense and coverage. The secondary, featuring cornerback Jeff Okudah, has shown improvement, though it remains a work in progress. Okudah’s ability to shadow top receivers has been valuable, but the unit as a whole has struggled at times against elite passing attacks. The Lions’ opportunistic defense has been effective in creating turnovers, helping to swing momentum in critical moments. Special teams have been a strength for Detroit, with kicker Riley Patterson delivering reliable performances and punter Jack Fox excelling in flipping field position. The return game has also been effective, occasionally setting up the offense with favorable starting field positions. Against the 49ers, the Lions will look to exploit San Francisco’s defensive vulnerabilities, particularly targeting the weaknesses in their Wide-9 scheme. Establishing the run early with Swift and Montgomery will be key to setting up play-action opportunities for Goff to connect with his receivers. Defensively, Detroit must focus on containing Christian McCaffrey and forcing Brock Purdy into mistakes by applying consistent pressure. With the No. 1 seed on the line, the Lions are motivated to deliver a strong performance. A win would solidify their position as the team to beat in the NFC and provide momentum heading into the playoffs. Expect Detroit to bring their best effort in this high-stakes matchup at Levi’s Stadium.

The Detroit Lions (13-2) will face the San Francisco 49ers (6-9) at Levi’s Stadium on Monday, December 30, 2024, at 5:15 PM PST. This Week 17 matchup holds significant implications for the Lions, who are vying to secure the top seed in the NFC, while the 49ers, eliminated from playoff contention, aim to play spoiler and end their season on a positive note. Detroit vs San Francisco AI Prediction: Free NFL Betting Insights for Dec 30. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Francisco 49ers NFL Preview

The San Francisco 49ers enter Week 17 with a 6-9 record, marking a season that has fallen short of expectations. Under head coach Kyle Shanahan, the team has faced numerous challenges, including a series of injuries to key players and inconsistencies on both sides of the ball. As they prepare to host the Detroit Lions, the 49ers aim to finish the season strong and build momentum for the future. Offensively, the 49ers have been led by quarterback Brock Purdy, who has shown flashes of potential but has also experienced typical growing pains associated with a young signal-caller. Purdy has passed for over 2,800 yards and 18 touchdowns but has also been prone to turnovers, with 12 interceptions on the season. Tight end George Kittle remains a cornerstone of the offense, leading the team in receptions and receiving yards, providing a reliable target in both intermediate and deep routes. The running game, anchored by Christian McCaffrey, has been a consistent positive, with McCaffrey accumulating over 1,200 rushing yards and 10 touchdowns, showcasing his versatility as both a runner and receiver out of the backfield. The offensive line has faced its share of challenges, particularly with injuries that have led to a lack of continuity. The recent signing of offensive lineman Charlie Heck aims to address some of these issues, providing additional depth and experience. Protecting Purdy and creating running lanes for McCaffrey will be crucial against a Lions defense known for its aggressive pass rush. Defensively, the 49ers have struggled, particularly with their implementation of the Wide -9 scheme, which has been exploited by opposing offenses throughout the season. Despite the presence of elite talent like Nick Bosa, the defensive line has underperformed, largely due to injuries to key players such as Javon Hargrave and Eric Armstead. Teams have successfully targeted the gaps created by the wide alignments, making it difficult for the 49ers to consistently stop the run and pressure quarterbacks. The secondary, led by veteran safety Talanoa Hufanga, has been inconsistent. Hufanga has provided standout moments with his ball-hawking abilities, but the overall unit has struggled with communication and coverage breakdowns, leading to big plays against them. The linebacking corps, headlined by Fred Warner, remains a strength, with Warner’s leadership and ability to cover sideline-to-sideline continuing to shine despite the team’s struggles. Special teams have been a point of inconsistency for the 49ers. Kicker Jake Moody has faced challenges in critical situations, missing a few key field goals that have cost the team in close games. The return game, while occasionally providing sparks, has not been a consistent source of field position advantage. Heading into this game against the Lions, the 49ers will need to focus on their strengths, particularly utilizing Christian McCaffrey in a variety of roles to keep Detroit’s defense off balance. Brock Purdy must make quick decisions to avoid turnovers, especially against a Lions defense that thrives on creating pressure. Defensively, limiting Jared Goff’s effectiveness and finding ways to disrupt the timing of Detroit’s receivers will be essential to slowing down their potent offense. Although the playoffs are out of reach, this game presents an opportunity for the 49ers to end their season on a high note and evaluate younger players for the future. Competing against a top-tier team like the Lions provides a valuable test of the roster’s depth and potential heading into the offseason.

Detroit vs. San Francisco Prop Picks (AI)

AI algorithm Remi is pouring through tons of data on each team. In fact, anytime the Lions and 49ers play there’s always several intriguing observations to key in on. Not to mention games played at Levi's Stadium in Dec can often follow normal, predictable betting trends.
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.

Detroit vs. San Francisco Prediction (AI)

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Remi, our AI sports genius, has been pouring over mountains of data from every facet between the Lions and 49ers and using recursive machine learning and impressive AI to examine the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most watching on the trending weight knucklehead sportsbettors often put on player performance factors between a Lions team going up against a possibly improved 49ers team. It appears the true game analytics appear to reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Detroit vs San Francisco picks, computer picks Lions vs 49ers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NFL 11/10 PHI@GB UNLOCK THIS PICK 6 VAULT v3 Locked VAULT v3
NFL 11/10 PHI@GB UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 11/10 PHI@GB UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 11/10 PHI@GB UNLOCK THIS PICK 1 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Lions Betting Trends

The Lions have been impressive against the spread (ATS) this season, boasting a 10-5 record. Their recent performances include a commanding 34-17 victory over the Chicago Bears, where they covered the spread as favorites. Detroit’s consistent offensive output and solid defense have contributed to their strong ATS performance throughout the season.

49ers Betting Trends

Conversely, the 49ers have struggled ATS, holding a 5-10 record. In their recent 29-17 loss to the Miami Dolphins, San Francisco failed to cover the spread, continuing a trend of underwhelming performances both on the field and for bettors. Injuries and inconsistent play have plagued the 49ers, impacting their ability to meet expectations.

Lions vs. 49ers Matchup Trends

An interesting ATS statistic to consider is the Lions’ success as road favorites this season, where they have covered the spread in three out of four games. This trend suggests that Detroit has been reliable when favored away from home, which could influence betting decisions for this matchup.

Detroit vs. San Francisco Game Info

Detroit vs San Francisco starts on December 30, 2024 at 9:15 PM EST.

Spread: San Francisco +3.5
Moneyline: Detroit -180, San Francisco +151
Over/Under: 50.5

Detroit: (13-2)  |  San Francisco: (6-9)

Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.

An interesting ATS statistic to consider is the Lions’ success as road favorites this season, where they have covered the spread in three out of four games. This trend suggests that Detroit has been reliable when favored away from home, which could influence betting decisions for this matchup.

DET trend: The Lions have been impressive against the spread (ATS) this season, boasting a 10-5 record. Their recent performances include a commanding 34-17 victory over the Chicago Bears, where they covered the spread as favorites. Detroit’s consistent offensive output and solid defense have contributed to their strong ATS performance throughout the season.

SF trend: Conversely, the 49ers have struggled ATS, holding a 5-10 record. In their recent 29-17 loss to the Miami Dolphins, San Francisco failed to cover the spread, continuing a trend of underwhelming performances both on the field and for bettors. Injuries and inconsistent play have plagued the 49ers, impacting their ability to meet expectations.

See our latest NFL picks and odds pages for 2024 to compare prices before you bet.

Detroit vs. San Francisco Odds

AI algorithm Remi is pouring through mountains of stats on each line. In fact, anytime the Detroit vs San Francisco trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable patterns.

Detroit vs San Francisco Opening Odds

DET Moneyline: -180
SF Moneyline: +151
DET Spread: -3.5
SF Spread: +3.5
Over/Under: 50.5

Detroit vs San Francisco Live Odds

Games PTS ML SPR O/U
Nov 13, 2025 8:15PM EST
New York Jets
New England Patriots
11/13/25 8:15PM
Jets
Patriots
+550
-800
+11.5 (-110)
-11.5 (-110)
O 43.5 (-105)
U 43.5 (-115)
Nov 16, 2025 9:30AM EST
Washington Commanders
Miami Dolphins
11/16/25 9:30AM
Commanders
Dolphins
+125
-150
+3 (-110)
-3 (-110)
O 47.5 (-110)
U 47.5 (-110)
Nov 16, 2025 1:00PM EST
Carolina Panthers
Atlanta Falcons
11/16/25 1PM
Panthers
Falcons
+160
-190
+3.5 (-110)
-3.5 (-110)
O 42.5 (-110)
U 42.5 (-110)
Nov 16, 2025 1:00PM EST
Chicago Bears
Minnesota Vikings
11/16/25 1PM
Bears
Vikings
+140
-170
+3 (-105)
-3 (-115)
O 48.5 (-110)
U 48.5 (-110)
Nov 16, 2025 1:00PM EST
Los Angeles Chargers
Jacksonville Jaguars
11/16/25 1PM
Chargers
Jaguars
-150
+125
-3 (-110)
+3 (-110)
O 44 (-110)
U 44 (-110)
Nov 16, 2025 1:00PM EST
Green Bay Packers
New York Giants
11/16/25 1PM
Packers
Giants
-400
+310
-7.5 (-110)
+7.5 (-110)
O 44.5 (-110)
U 44.5 (-110)
Nov 16, 2025 1:00PM EST
Cincinnati Bengals
Pittsburgh Steelers
11/16/25 1PM
Bengals
Steelers
+190
-240
+5.5 (-110)
-5.5 (-110)
O 49 (-110)
U 49 (-110)
Nov 16, 2025 1:00PM EST
Tampa Bay Buccaneers
Buffalo Bills
11/16/25 1PM
Buccaneers
Bills
+210
-260
+5.5 (-110)
-5.5 (-110)
O 49.5 (-110)
U 49.5 (-110)
Nov 16, 2025 1:00PM EST
Houston Texans
Tennessee Titans
11/16/25 1PM
Texans
Titans
-375
+300
-7 (-115)
+7 (-105)
O 39.5 (-110)
U 39.5 (-110)
Nov 16, 2025 4:05PM EST
San Francisco 49ers
Arizona Cardinals
11/16/25 4:05PM
49ers
Cardinals
-145
+120
-2.5 (-115)
+2.5 (-105)
O 49 (-110)
U 49 (-110)
Nov 16, 2025 4:05PM EST
Seattle Seahawks
Los Angeles Rams
11/16/25 4:05PM
Seahawks
Rams
+130
-160
+3 (-115)
-3 (-105)
O 48.5 (-110)
U 48.5 (-110)
Nov 16, 2025 4:25PM EST
Kansas City Chiefs
Denver Broncos
11/16/25 4:25PM
Chiefs
Broncos
-200
+165
-3.5 (-115)
+3.5 (-105)
O 44.5 (-110)
U 44.5 (-110)
Nov 16, 2025 4:25PM EST
Baltimore Ravens
Cleveland Browns
11/16/25 4:25PM
Ravens
Browns
-450
+350
-8.5 (-105)
+8.5 (-115)
O 41.5 (-110)
U 41.5 (-110)
Nov 16, 2025 8:20PM EST
Detroit Lions
Philadelphia Eagles
11/16/25 8:20PM
Lions
Eagles
+100
-120
+1.5 (-110)
-1.5 (-110)
O 48.5 (-115)
U 48.5 (-105)
Nov 17, 2025 8:15PM EST
Dallas Cowboys
Las Vegas Raiders
11/17/25 8:15PM
Cowboys
Raiders
-190
+160
-3.5 (-105)
+3.5 (-115)
O 50 (-110)
U 50 (-110)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Detroit Lions vs. San Francisco 49ers on December 30, 2024 at Levi's Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
LV@DEN RILEY MOSS OVER 4.5 TACKLE + ASST 54.8% 4 WIN
LV@DEN UNDER 43 53.4% 2 WIN
ARI@DAL BUDDA BAKER OVER 7.5 TACKLES + ASSTS 54.4% 4 WIN
ARI@DAL GEORGE PICKENS OVER 4.5 RECEPTIONS 56.6% 6 WIN
DEN@HOU WIL LUTZ OVER 1.5 MADE FIELD GOALS 54.2% 3 LOSS
SEA@WAS SEA -3 56.7% 6 WIN
IND@PIT IND -3 56.8% 6 LOSS
LAC@TEN LAC -9.5 56.2% 6 LOSS
CHI@CIN CHI -2.5 52.6% 2 WIN
SEA@WAS OVER 48 52.9% 2 WIN
SEA@WAS JAYDEN DANIELS OVER 20.5 PASS COMP 56.7% 6 LOSS
JAC@LV JAC -140 64.2% 7 WIN
NO@LAR LAR -14 55.0% 4 WIN
DEN@HOU HOU -1.5 54.2% 3 LOSS
CAR@GB GB -12.5 55.4% 5 LOSS
SF@NYG NYG +2.5 56.1% 5 LOSS
BAL@MIA TUA TAGOVAILOA UNDER 0.5 INT 55.3% 5 LOSS
TB@NO TB -3.5 52.3% 1 WIN
GB@PIT GB -2.5 52.3% 1 WIN
SF@HOU SF +2.5 56.0% 6 LOSS
NYG@PHI NYG +7.5 53.9% 3 LOSS
BUF@CAR CAR +7.5 54.2% 3 LOSS
DAL@DEN DAL +3.5 55.0% 4 LOSS
MIA@ATL MIA +7 54.3% 4 WIN
CLE@NE CLE +7 56.8% 6 LOSS
TB@NO BAKER MAYFIELD OVER 15.5 RUSH YDS 56.6% 6 LOSS
MIN@LAC JUSTIN HERBERT PASS ATT UNDER 35.5 55.5% 5 WIN
TB@DET TB +6.5 54.4% 4 LOSS
TB@DET RACHAAD WHITE UNDER 14.5 RUSH ATT 54.4% 4 WIN
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS