Titans vs Colts Prediction — AI Finds CAN'T MISS NFL Lines & Props (Dec 22)

Updated: 2024-12-15T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Tennessee Titans (3-11) are set to face the Indianapolis Colts (6-8) on December 22, 2024, at Lucas Oil Stadium in Indianapolis. Both teams are looking to rebound from recent losses, with the Titans aiming to end a four-game losing streak and the Colts striving to keep their slim playoff hopes alive.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Dec 22, 2024

Start Time: 2:00 PM EST​

Venue: Lucas Oil Stadium​

Colts Record: (6-8)

Titans Record: (3-11)

OPENING ODDS

TEN Moneyline: +179

IND Moneyline: -218

TEN Spread: +4.5

IND Spread: -4.5

Over/Under: 42.5

TEN
Betting Trends

  • The Titans have struggled against the spread (ATS) this season, holding a 4-10 ATS record. Their recent 37-27 loss to the Cincinnati Bengals marked their fourth consecutive game failing to cover the spread. Quarterback uncertainty and defensive lapses have contributed to their inability to meet betting expectations.

IND
Betting Trends

  • The Colts have been inconsistent ATS, standing at 7-7 for the season. In their latest outing, a 24-6 loss to the Detroit Lions, they failed to cover the spread as 7-point underdogs. Offensive struggles, particularly in the passing game, have hindered their performance against betting lines.

MATCHUP TRENDS

  • An interesting ATS statistic is the Titans’ performance as road underdogs. This season, they are 2-5 ATS when playing away from home and receiving points. Their inability to cover in these situations highlights challenges in overcoming deficits on the road.

TEN vs. IND
Best Prop Bet

  • Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.

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Tennessee vs Indianapolis Prediction & Odds:
Free NFL Betting Insights for 12/22/24

The Tennessee Titans and Indianapolis Colts renew their AFC South rivalry in a Week 16 matchup at Lucas Oil Stadium. The Titans, enduring a challenging season with a 3-11 record, are looking to play spoiler against the Colts, who at 6-8, are clinging to fading playoff aspirations. Tennessee’s offense has been in flux, particularly at the quarterback position. Head coach Brian Callahan has not committed to a starter for this game, following Will Levis’s benching after throwing three interceptions in the recent loss to the Bengals. Backup Mason Rudolph provided a spark, completing 21 of 26 passes for 209 yards and two touchdowns, but also threw an interception. The uncertainty under center has contributed to the Titans’ offensive inconsistencies. Running back Derrick Henry remains the focal point of Tennessee’s offense, amassing over 1,100 rushing yards and 10 touchdowns this season. However, without a reliable passing attack, defenses have focused on containing Henry, limiting his effectiveness. Wide receiver Treylon Burks has shown potential, leading the team with 700 receiving yards, but the passing game has lacked consistency. Defensively, the Titans have struggled, allowing an average of 28 points per game. The pass rush, led by Harold Landry III with 8 sacks, has been inconsistent, and the secondary has been vulnerable, surrendering big plays. Tennessee’s defense will need to tighten up to contain the Colts’ offense, which has its own set of challenges. The Colts are coming off a 24-6 loss to the Detroit Lions, a game that exposed their offensive deficiencies. Quarterback Anthony Richardson has had an up-and-down rookie season, showing flashes of brilliance but also making typical rookie mistakes.

He has thrown for over 2,800 yards with 18 touchdowns and 12 interceptions, adding 500 rushing yards and 6 touchdowns on the ground. Richardson’s dual-threat ability makes him a dangerous opponent, but ball security has been an issue. Running back Jonathan Taylor has been a bright spot, rushing for over 1,200 yards and 10 touchdowns. His ability to break big runs provides a spark for the offense. Wide receiver Michael Pittman Jr. leads the receiving corps with 900 yards and 6 touchdowns, but the passing game has lacked depth beyond him. Defensively, Indianapolis has been solid against the run, allowing just 105 rushing yards per game, which will be crucial against Derrick Henry. The pass defense, however, has been susceptible, giving up 250 yards per game through the air. Linebacker Shaquille Leonard anchors the defense with 110 tackles, and defensive end Kwity Paye leads the team with 9 sacks. Special teams could play a pivotal role in this matchup. Titans kicker Randy Bullock has been reliable, converting 85% of his field goal attempts, while Colts kicker Rodrigo Blankenship has been consistent as well. Field position and the ability to capitalize on scoring opportunities will be crucial for both teams. The betting line favors the Colts by 4.5 points, with an over/under set at 41.5 points. Given the Titans’ quarterback uncertainty and the Colts’ solid run defense, Indianapolis is expected to cover the spread. However, divisional games often defy expectations, and the Titans, despite their struggles, have the potential to keep the game competitive, especially if Derrick Henry can find success against the Colts’ front seven. In summary, this matchup features two teams with contrasting seasons. The Colts are fighting to keep their playoff hopes alive, while the Titans are looking to salvage pride in a disappointing campaign. The outcome will hinge on quarterback play, the effectiveness of the running games, and which defense can make pivotal stops.

Tennessee Titans NFL Preview

The Tennessee Titans enter Week 16 with a 3-11 record, traveling to Lucas Oil Stadium to face their division rival, the Indianapolis Colts. It has been a challenging season for Tennessee, marked by quarterback instability, inconsistent play on both sides of the ball, and struggles to close out games. Head coach Brian Callahan and his staff will look to rally the team for a strong finish to the season while embracing the role of spoiler. The Titans’ offense revolves around star running back Derrick Henry, who remains the heartbeat of the unit. Despite facing stacked boxes and defenses keying in on the run, Henry has rushed for over 1,100 yards and 10 touchdowns this season. His physical running style and ability to wear down defenses will be critical for Tennessee to stay competitive, particularly against an Indianapolis defense that has excelled at stopping the run. If Henry can establish himself early, it will open up play-action opportunities for the passing game. The quarterback position remains a significant question mark. Rookie Will Levis, who showed promise earlier in the season, has struggled in recent weeks, including a three-interception performance against the Bengals. Backup Mason Rudolph provided a spark in relief, completing 21 of 26 passes for 209 yards and two touchdowns. Whether Callahan sticks with Levis or gives Rudolph the start will be a key storyline heading into the game. Regardless of who plays, consistency and avoiding turnovers will be essential. Tennessee’s receiving corps, led by Treylon Burks, has shown flashes but remains inconsistent. Burks has totaled 700 receiving yards and has the size and athleticism to create mismatches, but injuries and quarterback struggles have limited his impact. Veteran wideout DeAndre Hopkins provides a reliable presence, though his production has dipped compared to his earlier years. Tight end Chigoziem Okonkwo has also been a solid target in short-yardage situations, but Tennessee’s passing attack ranks near the bottom of the league, averaging just 192 yards per game. Defensively, the Titans have struggled, allowing 28 points per game and often failing to make key stops. Linebacker Harold Landry III leads the team with 8 sacks, but the pass rush has been inconsistent. Without consistent pressure on opposing quarterbacks, the secondary has been exposed, giving up big plays and allowing an average of 260 passing yards per game. Cornerbacks Kristian Fulton and Roger McCreary will face a tough challenge against Michael Pittman Jr. and the Colts’ passing attack. The Titans’ run defense, typically a strength, has been less reliable this season, allowing 126 rushing yards per game. Stopping Jonathan Taylor will be a top priority, as the Colts’ offense is built around their star running back. Linebackers Azeez Al-Shaair and Monty Rice must play disciplined football to limit Taylor’s effectiveness and force the Colts into third-and-long situations. Special teams remain one of Tennessee’s more consistent areas, with kicker Randy Bullock converting 85% of his field goal attempts. However, the Titans will need to capitalize on all scoring opportunities, as points may be difficult to come by if their offense continues to struggle. For Tennessee to pull off an upset, they must lean heavily on Derrick Henry to control the tempo and keep the Colts’ offense off the field. Defensively, they will need to pressure Anthony Richardson and force him into mistakes, while the secondary must limit big plays. With pride on the line and the chance to disrupt the Colts’ playoff hopes, the Titans will look to play spoiler and finish the season with a competitive performance.

The Tennessee Titans (3-11) are set to face the Indianapolis Colts (6-8) on December 22, 2024, at Lucas Oil Stadium in Indianapolis. Both teams are looking to rebound from recent losses, with the Titans aiming to end a four-game losing streak and the Colts striving to keep their slim playoff hopes alive. Tennessee vs Indianapolis AI Prediction: Free NFL Betting Insights for Dec 22. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Indianapolis Colts NFL Preview

The Indianapolis Colts enter Week 16 with a 6-8 record, hosting the Tennessee Titans at Lucas Oil Stadium. Under head coach Shane Steichen, the Colts are striving to keep their slim playoff hopes alive, needing a win to stay in contention. Offensively, rookie quarterback Anthony Richardson has been at the helm, displaying both promise and growing pains. Richardson has accumulated over 2,800 passing yards, 18 touchdowns, and 12 interceptions, while also contributing 500 rushing yards and 6 touchdowns. His athleticism and arm strength have been evident, but decision-making and ball security remain areas for improvement. The ground game is spearheaded by Jonathan Taylor, who has rushed for over 1,200 yards and 10 touchdowns this season. Taylor’s physical running style and ability to break big plays make him the focal point of the Colts’ offense. Against a struggling Titans defense, Taylor has an opportunity to have a significant impact, especially if Indianapolis can control the clock and wear down Tennessee’s front seven. Backup running back Zack Moss has also been productive in a complementary role, giving the Colts flexibility in their rushing attack. In the passing game, Michael Pittman Jr. has been the standout receiver, leading the team with over 900 receiving yards and 6 touchdowns. Pittman’s size and reliable hands make him a go-to option for Richardson, particularly in contested catch situations. Rookie Josh Downs has emerged as a solid secondary option in the slot, while tight ends Kylen Granson and Jelani Woods provide Richardson with reliable targets in short-yardage and red-zone situations. However, the Colts’ passing attack remains inconsistent, often struggling to stretch the field against more disciplined secondaries. The offensive line, anchored by Quenton Nelson, has had an up-and-down season but remains capable of dominating at the point of attack. Protecting Richardson will be key in this matchup, especially against a Titans defense that, while inconsistent, features playmakers like Harold Landry III who can disrupt the pocket. Defensively, the Colts have been solid, particularly against the run, where they rank in the top 10 in the NFL, allowing just 105 rushing yards per game. This strength will be critical as they face Derrick Henry, one of the league’s premier power backs. Defensive tackles DeForest Buckner and Grover Stewart anchor the interior and will need to win their battles at the line of scrimmage to keep Henry contained. The Colts’ pass rush, led by Kwity Paye and Samson Ebukam, has been effective at times, tallying 36 sacks this season. Generating consistent pressure on Tennessee’s quarterback—whether it’s Will Levis or Mason Rudolph—will be key in forcing mistakes and keeping the Titans’ offense off balance. Linebacker Shaquille Leonard remains the leader of the defense, with his 110 tackles and playmaking ability setting the tone for the unit. The secondary, however, has been more vulnerable, allowing over 250 passing yards per game. Cornerbacks Kenny Moore II and JuJu Brents will need to step up against the Titans’ receiving corps, particularly Treylon Burks, who has the potential to create big plays downfield. Safeties Julian Blackmon and Rodney Thomas II must also remain disciplined to prevent Tennessee from exploiting soft zones. On special teams, kicker Rodrigo Blankenship has been steady, converting 86% of his field goal attempts, while punter Rigoberto Sanchez continues to excel at flipping field position. With the Colts likely to rely on field position and clock management, special teams could play a critical role in securing a victory. The Colts’ path to victory hinges on their ability to dominate the line of scrimmage on both sides of the ball. Offensively, they will look to establish Jonathan Taylor early and allow Richardson to play within the system without forcing risky throws. Defensively, they must contain Derrick Henry and pressure Tennessee’s quarterback into mistakes. With slim playoff hopes on the line, expect the Colts to approach this game with urgency and focus as they aim to take care of business at home.

Tennessee vs. Indianapolis Prop Picks (AI)

AI algorithm Remi is pouring through tons of datapoints on each player. In fact, anytime the Titans and Colts play there’s always several intriguing observations to key in on. Not to mention games played at Lucas Oil Stadium in Dec seemingly never follow normal, predictable patterns.
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.

Tennessee vs. Indianapolis Prediction (AI)

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Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every simulation between the Titans and Colts and using recursive machine learning and kick-ass AI to crunch the data to a single cover probability.

Remi has been most fixated on the trending emphasis emotional bettors tend to put on Tennessee’s strength factors between a Titans team going up against a possibly deflated Colts team. It appears the true game analytics might reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Tennessee vs Indianapolis picks, computer picks Titans vs Colts, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NFL 10/20 HOU@SEA UNLOCK THIS PICK 5 INTEL Locked INTEL
NFL 10/20 TB@DET UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/20 TB@DET UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/20 TB@DET UNLOCK THIS PICK 1 INTEL Locked INTEL
NFL 10/20 HOU@SEA UNLOCK THIS PICK 0 INTEL Locked INTEL
NFL 10/20 TB@DET UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Titans Betting Trends

The Titans have struggled against the spread (ATS) this season, holding a 4-10 ATS record. Their recent 37-27 loss to the Cincinnati Bengals marked their fourth consecutive game failing to cover the spread. Quarterback uncertainty and defensive lapses have contributed to their inability to meet betting expectations.

Colts Betting Trends

The Colts have been inconsistent ATS, standing at 7-7 for the season. In their latest outing, a 24-6 loss to the Detroit Lions, they failed to cover the spread as 7-point underdogs. Offensive struggles, particularly in the passing game, have hindered their performance against betting lines.

Titans vs. Colts Matchup Trends

An interesting ATS statistic is the Titans’ performance as road underdogs. This season, they are 2-5 ATS when playing away from home and receiving points. Their inability to cover in these situations highlights challenges in overcoming deficits on the road.

Tennessee vs. Indianapolis Game Info

Tennessee vs Indianapolis starts on December 22, 2024 at 2:00 PM EST.

Spread: Indianapolis -4.5
Moneyline: Tennessee +179, Indianapolis -218
Over/Under: 42.5

Tennessee: (3-11)  |  Indianapolis: (6-8)

Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.

An interesting ATS statistic is the Titans’ performance as road underdogs. This season, they are 2-5 ATS when playing away from home and receiving points. Their inability to cover in these situations highlights challenges in overcoming deficits on the road.

TEN trend: The Titans have struggled against the spread (ATS) this season, holding a 4-10 ATS record. Their recent 37-27 loss to the Cincinnati Bengals marked their fourth consecutive game failing to cover the spread. Quarterback uncertainty and defensive lapses have contributed to their inability to meet betting expectations.

IND trend: The Colts have been inconsistent ATS, standing at 7-7 for the season. In their latest outing, a 24-6 loss to the Detroit Lions, they failed to cover the spread as 7-point underdogs. Offensive struggles, particularly in the passing game, have hindered their performance against betting lines.

See our latest NFL picks and odds pages for 2024 to compare prices before you bet.

Tennessee vs. Indianapolis Odds

AI algorithm Remi is pouring through loads of data on each player. In fact, anytime the Tennessee vs Indianapolis trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable betting trends.

Tennessee vs Indianapolis Opening Odds

TEN Moneyline: +179
IND Moneyline: -218
TEN Spread: +4.5
IND Spread: -4.5
Over/Under: 42.5

Tennessee vs Indianapolis Live Odds

Games PTS ML SPR O/U
Oct 23, 2025 8:15PM EDT
Minnesota Vikings
Los Angeles Chargers
10/23/25 8:15PM
Vikings
Chargers
+133
-167
+3 (-114)
-3 (-112)
O 44.5 (-113)
U 44.5 (-113)
Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
+265
-375
+7 (-118)
-7 (-108)
O 40.5 (-109)
U 40.5 (-117)
Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
-500
+340
-7.5 (-115)
+7.5 (-110)
O 46.5 (-112)
U 46.5 (-113)
Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
+235
-315
+6.5 (-112)
-6.5 (-114)
O 44 (-109)
U 44 (-115)
Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
+260
-360
+6.5 (-110)
-6.5 (-115)
O 50 (-115)
U 50 (-109)
Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
+275
-385
+7 (-113)
-7 (-113)
O 43 (-114)
U 43 (-112)
Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
-109
-117
+1 (-115)
-1 (-109)
O 41 (-115)
U 41 (-110)
Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
+295
-420
+7 (-108)
-7 (-118)
O 44.5 (-113)
U 44.5 (-113)
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
-245
+185
-4.5 (-115)
+4.5 (-110)
O 47.5 (-109)
U 47.5 (-117)
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
+135
-175
+3.5 (-118)
-3.5 (-108)
O 50 (-109)
U 50 (-117)
Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
+650
-1250
+14 (-108)
-14 (-118)
O 47 (-113)
U 47 (-113)
Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
-177
+135
-3 (-113)
+3 (-113)
O 45 (-112)
U 45 (-113)
Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
+420
-670
+10.5 (-114)
-10.5 (-112)
O 48 (-113)
U 48 (-113)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Tennessee Titans vs. Indianapolis Colts on December 22, 2024 at Lucas Oil Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS
HOU@BAL HOU -125 58.5% 7 WIN
DET@CIN DET -10 55.6% 5 WIN
DAL@NYJ NYJ +1.5 53.7% 3 LOSS
TB@SEA TB +3.5 54.9% 4 WIN
TEN@ARI ARI -7 (BUY 0.5) 54.9% 4 LOSS
DEN@PHI DEN +4.5 57.5% 7 WIN
MIA@CAR TETAIROA MCMILLAN OVER 58.5 RECV YDS 54.5% 4 WIN
LV@IND ASHTON JEANTY UNDER 67.5 RUSH YDS 54.4% 4 WIN
SF@LAR DEMARCUS ROBINSON OVER 29.5 RECV YDS 55.7% 5 WIN
NYJ@MIA NYJ +3 53.8 3 LOSS
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS
TEN@HOU TEN +7.5 57.9% 7 LOSS
LAC@NYG LAC -6 57.3% 7 LOSS
NO@BUF UNDER 48.5 55.1% 3 LOSS
GB@DAL JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS 55.5% 5 LOSS
CAR@NE DRAKE MAYE TO THROW AN INT 56.6% 6 LOSS
SEA@ARI SEA -125 57.7% 6 WIN
SEA@ARI KYLER MURRAY TO THROW AN INT 56.6% 6 WIN
DET@BAL JAHMYR GIBBS OVER 0.5 RUSH TDS 55.8% 5 WIN
DAL@CHI DAL -120 58.7% 6 LOSS
PIT@NE PIT -116 60.1% 6 WIN
ATL@CAR ATL -4.5 55.4% 5 LOSS
LV@WAS LV +3 54.3% 4 LOSS