49ers vs Dolphins Prediction — AI Finds CAN'T MISS NFL Lines & Props (Dec 22)
Updated: 2024-12-15T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The San Francisco 49ers (6-8) are set to face the Miami Dolphins (7-7) on December 22, 2024, at Hard Rock Stadium in Miami. Both teams are vying for playoff positions, making this matchup crucial for their postseason aspirations.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Dec 22, 2024
Start Time: 5:25 PM EST
Venue: Hard Rock Stadium
Dolphins Record: (6-8)
49ers Record: (6-8)
OPENING ODDS
SF Moneyline: +105
MIA Moneyline: -124
SF Spread: +1.5
MIA Spread: -1.5
Over/Under: 46
SF
Betting Trends
- The 49ers have been inconsistent against the spread (ATS) this season, holding a 6-8 record. They have failed to cover the spread in their last two games, including a 35-10 loss to the Buffalo Bills, where they were 6.5-point underdogs. Injuries to key players, such as wide receiver Brandon Aiyuk and safety Talanoa Hufanga, have significantly impacted their performance and betting outcomes.
MIA
Betting Trends
- The Dolphins have fared slightly better ATS, with a 7-7 record this season. They have covered the spread in three of their last four games, including a 34-15 victory over the New England Patriots, where they were favored by 7.5 points. Quarterback Tua Tagovailoa’s improved play and a dynamic offense have been pivotal in meeting betting expectations.
MATCHUP TRENDS
- An interesting ATS statistic is that the 49ers are 4-2 ATS in their last six games against the Dolphins. However, with the 49ers’ recent struggles and the Dolphins’ momentum, this trend may be tested in the upcoming matchup.
SF vs. MIA
Best Prop Bet
- Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.
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San Francisco vs Miami Prediction & Odds:
Free NFL Betting Insights for 12/22/24
The offensive line has been effective, allowing Tagovailoa to operate efficiently from the pocket. Defensively, Miami allows 318.5 yards per game, ranking sixth in the league. The pass defense has been sturdy, conceding 197.5 yards per game. The defensive front, even after the loss of linebacker Jaelan Phillips to injury, has managed to maintain pressure, recording 32 sacks on the season. The secondary, led by cornerback Xavien Howard, has been opportunistic, contributing to a positive turnover differential. Special teams could play a crucial role in this matchup. The 49ers’ kicker, Jake Moody, has been reliable, converting 85% of his field goal attempts, while punter Mitch Wishnowsky has been effective in pinning opponents deep. The Dolphins’ special teams unit has also been solid, with kicker Jason Sanders displaying consistency and the return game providing advantageous field positions. For the 49ers to succeed, establishing the run with McCaffrey to control the clock and setting up play-action opportunities will be essential. Defensively, generating pressure on Tagovailoa and containing the deep threats of Hill and Waddle will be critical to limiting Miami’s explosive plays. The Dolphins will aim to exploit the 49ers’ secondary, utilizing their speed on the outside, while maintaining a balanced attack to keep San Francisco’s defense off balance. Defensively, focusing on stopping the run and forcing Purdy into third-and-long situations will enhance their chances of creating turnovers. In summary, this game features two teams with playoff aspirations hanging in the balance. The outcome may hinge on each team’s ability to execute their game plan effectively, manage turnovers, and capitalize on key opportunities. With both teams facing pressure to secure a win, fans can anticipate a highly competitive and strategically intense matchup.
Final. #ATLvsLV pic.twitter.com/bBALzZ1D3X
— Las Vegas Raiders (@Raiders) December 17, 2024
San Francisco 49ers NFL Preview
The San Francisco 49ers enter Week 16 with a 6-8 record, fighting to keep their slim playoff hopes alive as they travel to face the Miami Dolphins at Hard Rock Stadium. The 49ers’ season has been marked by inconsistency, stemming from injuries to key contributors and fluctuating performances on both sides of the ball. Nevertheless, San Francisco remains a dangerous team capable of competing with any opponent when firing on all cylinders. Offensively, the 49ers have relied heavily on their star running back Christian McCaffrey, who continues to be one of the league’s most dynamic playmakers. McCaffrey has rushed for over 1,200 yards and 10 touchdowns this season while adding 500 receiving yards and 4 scores through the air. His versatility allows head coach Kyle Shanahan to scheme creative plays, utilizing McCaffrey as both a rusher and a receiver to keep defenses guessing. Against a strong Dolphins run defense, McCaffrey’s ability to break tackles and create yards after contact will be critical. Quarterback Brock Purdy has stepped in as the starter and has performed admirably under the circumstances. Purdy has thrown for 2,500 yards and 18 touchdowns, but he has struggled with turnovers in recent weeks, throwing 6 interceptions over the past four games. Without key receiving options like Brandon Aiyuk, who has been sidelined with injury, Purdy has leaned heavily on tight end George Kittle. Kittle leads the team with 850 receiving yards and 6 touchdowns, serving as a safety valve in critical situations. Wide receiver Deebo Samuel’s return provides a much-needed spark, as his physicality and versatility create mismatches all over the field. San Francisco’s offensive line has been inconsistent, allowing 30 sacks this season. Left tackle Trent Williams remains one of the league’s best, but injuries and rotational struggles on the right side have left Purdy vulnerable to pressure. Against a Dolphins pass rush led by Bradley Chubb and Christian Wilkins, the 49ers must prioritize protection and quick throws to avoid costly turnovers. Defensively, the 49ers have been solid despite some setbacks. Edge rusher Nick Bosa remains the anchor of the defensive line, recording 11 sacks and generating consistent pressure. However, injuries to key players like safety Talanoa Hufanga and linebacker Dre Greenlaw have created gaps in the defense, particularly in the middle of the field. Linebacker Fred Warner continues to lead the unit with 110 tackles, providing leadership and playmaking ability. The secondary will face a daunting challenge against Miami’s elite wide receivers Tyreek Hill and Jaylen Waddle. Cornerbacks Charvarius Ward and Deommodore Lenoir will need to play disciplined football, while the pass rush must limit Tua Tagovailoa’s time in the pocket. If the 49ers can generate consistent pressure and disrupt Miami’s rhythm, they will have a chance to force turnovers and keep the game within reach. Special teams have been a bright spot for San Francisco, with kicker Jake Moody converting 85% of his field goal attempts and punter Mitch Wishnowsky excelling in pinning opponents deep. In a close contest, field position and special teams execution could play a pivotal role. The 49ers’ path to victory relies on establishing the run game with McCaffrey to control the clock and limit Miami’s offensive opportunities. Brock Purdy must play efficiently, avoiding turnovers while finding creative ways to get the ball to Kittle and Samuel. Defensively, containing Hill and Waddle will be the top priority, with Bosa and the defensive line tasked with generating pressure on Tagovailoa. Facing a must-win scenario, the 49ers will look to bring their trademark physicality and execute Shanahan’s balanced game plan. A victory in Miami would keep San Francisco’s playoff hopes alive while providing momentum heading into the final stretch of the season.

Credit: USA TODAY/IMAGN
Miami Dolphins NFL Preview
The Miami Dolphins, standing at 7-7, are set to host the San Francisco 49ers in a critical Week 16 matchup at Hard Rock Stadium. With playoff implications on the line, the Dolphins are focused on leveraging their home-field advantage to secure a pivotal victory. Offensively, the Dolphins have been dynamic, averaging 394 yards per game, which ranks fourth in the NFL. Quarterback Tua Tagovailoa has been at the helm of this high-powered offense, throwing for over 3,500 yards and 25 touchdowns. His accuracy and quick decision-making have been instrumental in the team’s success. Tagovailoa’s chemistry with his elite receiving duo, Tyreek Hill and Jaylen Waddle, has been the cornerstone of Miami’s passing attack. Hill, leading the NFL with over 1,300 receiving yards and 11 touchdowns, remains a matchup nightmare for any defense with his speed and ability to stretch the field. Waddle, complementing Hill, has added 900 receiving yards and 7 touchdowns, thriving in underneath routes and yards-after-catch situations. This duo creates challenges for opposing secondaries and allows Miami to attack all areas of the field. The Dolphins’ ground game has been equally important in balancing the offense. Running back Raheem Mostert has emerged as the team’s top back, rushing for 1,000 yards and 9 touchdowns while showcasing his speed and vision. Jeff Wilson Jr. has been an effective complementary option, particularly in short-yardage and goal-line situations. Miami’s ability to run the ball has forced defenses to respect play-action, creating further opportunities for Tagovailoa to exploit mismatches downfield. Miami’s offensive line has shown improvement, allowing fewer sacks and giving Tagovailoa the time needed to execute the quick passing game. Terron Armstead, anchoring the left side of the line, has been key in pass protection and setting the tone in the run game. Against a San Francisco defense featuring Nick Bosa, the line’s performance will be critical in ensuring Tagovailoa stays upright and avoids costly turnovers. Defensively, the Dolphins have been impressive, ranking sixth in total defense and allowing just 318.5 yards per game. The pass defense has been a particular strength, holding opponents to under 200 yards per game through the air. Cornerback Xavien Howard remains the leader of the secondary, often tasked with shutting down the opposing team’s top receiver. His experience and ball-hawking skills have been vital in creating turnovers, while safety Jevon Holland provides support over the top and is a force in run defense. The Dolphins’ pass rush has been effective despite injuries to key contributors like linebacker Jaelan Phillips. Christian Wilkins and Bradley Chubb have stepped up, combining for 12 sacks and providing consistent pressure on opposing quarterbacks. Against a 49ers offense that relies on Brock Purdy’s efficiency and Christian McCaffrey’s explosiveness, Miami’s front seven will focus on limiting the run game and forcing Purdy into uncomfortable passing situations. Special teams have been solid for Miami, with kicker Jason Sanders converting 87% of his field goal attempts this season. Sanders’ reliability in close games has been crucial, and punter Jake Bailey has effectively pinned opponents deep, flipping field position when necessary. Miami’s return game, led by Braxton Berrios, has provided sparks, helping set up favorable field position for the offense. The key to Miami’s success in this game will be establishing an early lead and forcing the 49ers to play from behind. The Dolphins’ quick-strike offense, paired with a physical defense, is well-suited to put pressure on teams that struggle to play catch-up. Tagovailoa’s ability to distribute the ball effectively to Hill, Waddle, and his tight ends will be central to their game plan, while Mostert and Wilson will need to maintain balance with the run. Defensively, the Dolphins must contain Christian McCaffrey, as his ability to impact both the run and passing games can keep San Francisco in rhythm. Generating pressure on Brock Purdy and forcing him into mistakes will allow Miami to capitalize on any turnovers and control momentum. With playoff positioning on the line, expect the Dolphins to bring intensity and energy in front of their home crowd as they look to secure a crucial victory.
Final. pic.twitter.com/SIHHStRsAc
— Miami Dolphins (@MiamiDolphins) December 15, 2024
San Francisco vs. Miami Prop Picks (AI)
San Francisco vs. Miami Prediction (AI)

Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every facet between the 49ers and Dolphins and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most watching on the linear correlation of weight human bettors tend to put on player performance factors between a 49ers team going up against a possibly deflated Dolphins team. Trends look to say the true game analytics might reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI San Francisco vs Miami picks, computer picks 49ers vs Dolphins, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 5 |
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NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 1 |
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NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 0 |
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NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
49ers Betting Trends
The 49ers have been inconsistent against the spread (ATS) this season, holding a 6-8 record. They have failed to cover the spread in their last two games, including a 35-10 loss to the Buffalo Bills, where they were 6.5-point underdogs. Injuries to key players, such as wide receiver Brandon Aiyuk and safety Talanoa Hufanga, have significantly impacted their performance and betting outcomes.
Dolphins Betting Trends
The Dolphins have fared slightly better ATS, with a 7-7 record this season. They have covered the spread in three of their last four games, including a 34-15 victory over the New England Patriots, where they were favored by 7.5 points. Quarterback Tua Tagovailoa’s improved play and a dynamic offense have been pivotal in meeting betting expectations.
49ers vs. Dolphins Matchup Trends
An interesting ATS statistic is that the 49ers are 4-2 ATS in their last six games against the Dolphins. However, with the 49ers’ recent struggles and the Dolphins’ momentum, this trend may be tested in the upcoming matchup.
San Francisco vs. Miami Game Info
What time does San Francisco vs Miami start on December 22, 2024?
San Francisco vs Miami starts on December 22, 2024 at 5:25 PM EST.
Where is San Francisco vs Miami being played?
Venue: Hard Rock Stadium.
What are the opening odds for San Francisco vs Miami?
Spread: Miami -1.5
Moneyline: San Francisco +105, Miami -124
Over/Under: 46
What are the records for San Francisco vs Miami?
San Francisco: (6-8) | Miami: (6-8)
What is the AI best bet for San Francisco vs Miami?
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.
What are San Francisco vs Miami trending bets?
An interesting ATS statistic is that the 49ers are 4-2 ATS in their last six games against the Dolphins. However, with the 49ers’ recent struggles and the Dolphins’ momentum, this trend may be tested in the upcoming matchup.
What are San Francisco trending bets?
SF trend: The 49ers have been inconsistent against the spread (ATS) this season, holding a 6-8 record. They have failed to cover the spread in their last two games, including a 35-10 loss to the Buffalo Bills, where they were 6.5-point underdogs. Injuries to key players, such as wide receiver Brandon Aiyuk and safety Talanoa Hufanga, have significantly impacted their performance and betting outcomes.
What are Miami trending bets?
MIA trend: The Dolphins have fared slightly better ATS, with a 7-7 record this season. They have covered the spread in three of their last four games, including a 34-15 victory over the New England Patriots, where they were favored by 7.5 points. Quarterback Tua Tagovailoa’s improved play and a dynamic offense have been pivotal in meeting betting expectations.
Where can I find AI Picks for San Francisco vs Miami?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
San Francisco vs. Miami Odds
Remi is pouring through loads of stats on each player. In fact, anytime the San Francisco vs Miami trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance seemingly never follow normal, predictable patterns.
San Francisco vs Miami Opening Odds
SF Moneyline:
+105 MIA Moneyline: -124
SF Spread: +1.5
MIA Spread: -1.5
Over/Under: 46
San Francisco vs Miami Live Odds
Games | PTS | ML | SPR | O/U | |
---|---|---|---|---|---|
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Minnesota Vikings
Los Angeles Chargers
10/23/25 8:15PM
Vikings
Chargers
|
–
–
|
+148
-185
|
+3 (+100)
-3 (-120)
|
O 44.5 (-110)
U 44.5 (-110)
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Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
|
–
–
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+270
-374
|
+7 (-110)
-7 (-110)
|
O 40.5 (-110)
U 40.5 (-110)
|
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Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
|
–
–
|
-463
+321
|
-7.5 (-110)
+7.5 (-110)
|
O 46 (-110)
U 46 (-110)
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|
Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
|
–
–
|
+242
-330
|
+7 (-110)
-7 (-110)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
|
–
–
|
+229
-315
|
+6.5 (+100)
-6.5 (-120)
|
O 50.5 (-110)
U 50.5 (-110)
|
|
Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
|
–
–
|
+287
-407
|
+7 (-110)
-7 (-110)
|
O 43.5 (-110)
U 43.5 (-110)
|
|
Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
|
–
–
|
-110
-116
|
+1 (-110)
-1 (-110)
|
O 41.5 (-110)
U 41.5 (-110)
|
|
Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
|
–
–
|
+257
-355
|
+7 (-110)
-7 (-110)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
|
–
–
|
-220
+169
|
-4.5 (-110)
+4.5 (-110)
|
O 47 (-110)
U 47 (-110)
|
|
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
|
–
–
|
+141
-181
|
+3.5 (-120)
-3.5 (+100)
|
O 50 (-110)
U 50 (-110)
|
|
Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
|
–
–
|
+682
-1442
|
+14 (-110)
-14 (-110)
|
O 47 (-110)
U 47 (-110)
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Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
|
–
–
|
-192
+148
|
-3.5 (+100)
+3.5 (-120)
|
O 44.5 (-110)
U 44.5 (-110)
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Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
|
–
–
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+390
-599
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+10.5 (-110)
-10.5 (-110)
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O 47.5 (-110)
U 47.5 (-110)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Francisco 49ers vs. Miami Dolphins on December 22, 2024 at Hard Rock Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
GB@ARI | ARI +7 | 54.8% | 5 | WIN |
NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
DET@CIN | DET -10 | 55.6% | 5 | WIN |
DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
PIT@NE | PIT -116 | 60.1% | 6 | WIN |
ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
LV@WAS | LV +3 | 54.3% | 4 | LOSS |