Bills vs Lions Prediction — AI Finds CAN'T MISS NFL Lines & Props (Dec 15)

Updated: 2024-12-08T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Buffalo Bills (10-3) will face the Detroit Lions (12-1) on December 15, 2024, at Ford Field in Detroit. This highly anticipated matchup features two of the NFL’s top offenses, both vying for favorable playoff positioning.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Dec 15, 2024

Start Time: 5:25 PM EST​

Venue: Ford Field​

Lions Record: (12-1)

Bills Record: (10-3)

OPENING ODDS

BUF Moneyline: +118

DET Moneyline: -140

BUF Spread: +2.5

DET Spread: -2.5

Over/Under: 54.5

BUF
Betting Trends

  • The Bills have been strong against the spread (ATS) this season, with a 7-6 record overall and 4-2 ATS on the road. Their offense averages 30.5 points per game, often surpassing projected totals.

DET
Betting Trends

  • The Lions boast an impressive 9-4 ATS record, including 5-2 at home. Their defense allows an average of 18 points per game, contributing to a 1-4 under record in their last five home games.

MATCHUP TRENDS

  • Notably, the over/under for this game is set at 53.5 points, reflecting the high-scoring potential of both teams.

BUF vs. DET
Best Prop Bet

  • Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.

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Buffalo vs Detroit Prediction & Odds:
Free NFL Betting Insights for 12/15/24

The Week 15 clash between the Buffalo Bills and the Detroit Lions is poised to be a marquee matchup, featuring two of the NFL’s most potent offenses. The Lions, with a 12-1 record, lead the NFC North and have secured a postseason berth. Their offense averages 32.1 points per game, ranking first in the league. Quarterback Jared Goff has been instrumental, passing for over 3,200 yards and maintaining a high passer rating. The ground game, led by David Montgomery and Jahmyr Gibbs, contributes significantly, with the team averaging 151.1 rushing yards per game. Wide receiver Amon-Ra St. Brown leads the receiving corps, providing a reliable target for Goff. Defensively, the Lions are formidable, allowing just 18 points per game, the second-best in the NFL. Their run defense is particularly stout, ranking fifth and conceding only 94.9 yards per game. However, the pass defense has shown vulnerability, ranking 25th and allowing 227.2 yards per game. Injuries have impacted the defensive line, with key players like Alim McNeill potentially sidelined, though the return of DJ Reader could bolster their front. The Bills enter the game with a 10-3 record, leading the AFC East.

Their offense averages 30.5 points per game, second only to the Lions. Quarterback Josh Allen is having an MVP-caliber season, accounting for a significant portion of the team’s offensive production. In a recent game against the Los Angeles Rams, Allen threw for 342 yards and three touchdowns, and rushed for 82 yards with three additional scores. The Bills’ defense, however, has been inconsistent, allowing 20.6 points per game and ranking 14th in total defense. Their pass defense is stronger, ranking ninth, but the run defense lags at 19th. Special teams could play a pivotal role in this matchup. The Lions’ special teams have been strong, with reliable kicking and effective return units. Conversely, the Bills have faced challenges, including critical coaching mistakes and special teams errors in recent games. Betting lines reflect the competitiveness of this game. The Lions opened as 2.5-point favorites, with an over/under set at 53.5 points, indicating expectations of a high-scoring affair. The Bills’ recent performance as road underdogs and the Lions’ strong home record add layers of intrigue for bettors. In summary, this game features two high-powered offenses and defenses with distinct strengths and weaknesses. The outcome may hinge on which defense can make critical stops and how effectively each team manages turnovers. With both teams eyeing favorable playoff positioning, fans can anticipate an intense and closely contested battle at Ford Field.

Buffalo Bills NFL Preview

The Buffalo Bills, with a 10-3 record, travel to Detroit to face the 12-1 Lions in a highly anticipated Week 15 matchup. The Bills, sitting atop the AFC East, are in a strong position to secure a playoff spot but face a tough challenge against a Lions team that has been dominant this season. Head coach Sean McDermott has emphasized the importance of maintaining focus and executing at a high level as his team prepares for one of its biggest tests of the season. Offensively, the Bills are a juggernaut, averaging 30.5 points per game, second in the NFL. Quarterback Josh Allen is having an MVP-caliber season, accounting for over 4,200 total yards and 38 touchdowns (32 passing, 6 rushing). Allen’s ability to make plays both through the air and on the ground makes him one of the most difficult players to defend in the league. Wide receiver Stefon Diggs leads the team with 1,214 receiving yards and 10 touchdowns, while rookie tight end Dalton Kincaid has emerged as a reliable target in the red zone. The Bills’ running game, while not the focal point of their offense, has been effective when called upon. James Cook has led the backfield with 728 rushing yards and four touchdowns, providing balance and complementing Allen’s mobility. The offensive line has been solid in pass protection, allowing Allen the time he needs to exploit defenses. However, the Bills’ offensive success has occasionally been hindered by turnovers, an area they will need to clean up against a disciplined Lions defense. Defensively, the Bills rank 14th in the league, allowing 20.6 points per game. Their pass defense has been a strength, ranking ninth and conceding just 209.5 yards per game through the air. However, the run defense has been less consistent, allowing 112.3 yards per game, ranking 19th. The absence of Von Miller, who has been limited by injuries, has impacted their pass rush, though Greg Rousseau and Ed Oliver have stepped up to provide pressure on opposing quarterbacks. The Bills’ secondary, led by Tre’Davious White and Jordan Poyer, has been opportunistic, forcing 14 interceptions this season. The defense’s ability to create turnovers and disrupt Detroit’s offensive rhythm will be critical in this game. Containing Jared Goff and limiting the effectiveness of the Lions’ potent rushing attack will be the primary focus for McDermott and his defensive staff. Special teams have been a mixed bag for Buffalo. Kicker Tyler Bass has been reliable from short distances but has struggled from beyond 50 yards. The return game, led by Deonte Harty, has provided occasional sparks but has not been a consistent factor. The Bills will need a clean performance from their special teams unit to avoid giving the Lions any additional opportunities. As the Bills prepare for this pivotal matchup, their focus will be on playing mistake-free football and capitalizing on scoring opportunities. A win in Detroit would solidify their position in the AFC playoff race and serve as a statement victory against one of the NFL’s best teams. If Buffalo can execute its game plan effectively, the Bills have the talent and experience to prevail in this marquee matchup.

The Buffalo Bills (10-3) will face the Detroit Lions (12-1) on December 15, 2024, at Ford Field in Detroit. This highly anticipated matchup features two of the NFL’s top offenses, both vying for favorable playoff positioning. Buffalo vs Detroit AI Prediction: Free NFL Betting Insights for Dec 15. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Detroit Lions NFL Preview

The Detroit Lions, boasting a 12-1 record, have emerged as one of the NFL’s premier teams in the 2024 season. Under head coach Dan Campbell’s leadership, the Lions have secured a postseason berth and are focused on maintaining their momentum as they host the Buffalo Bills in Week 15. Offensively, the Lions lead the league with an average of 32.1 points per game. Quarterback Jared Goff has been a catalyst, passing for over 3,200 yards and maintaining a high passer rating. His command of the offense and ability to distribute the ball effectively have been key to the team’s success. The running back duo of David Montgomery and rookie Jahmyr Gibbs has been formidable, contributing to the team’s 151.1 rushing yards per game, ranking fourth in the NFL. Montgomery’s power running complements Gibbs’ speed and agility, creating a balanced and dynamic ground attack. Wide receiver Amon-Ra St. Brown leads the receiving corps with 863 yards, providing a reliable target and demonstrating exceptional route-running and hands. Defensively, the Lions have been impressive, allowing just 18 points per game, the second-best mark in the league. Their run defense is particularly strong, conceding only 94.9 yards per game, ranking fifth. This stout run defense forces opponents into passing situations, allowing the Lions’ pass rush to capitalize. However, the pass defense has been a point of concern, allowing 227.2 yards per game, ranking 25th. Injuries have impacted the defensive line, with key players like Alim McNeill potentially sidelined. The anticipated return of DJ Reader could bolster the front line, providing much-needed depth and experience. Linebacker Alex Anzalone has been a leader on defense, orchestrating plays and contributing significantly in tackles. Special teams have been a consistent asset for the Lions. Kicker Riley Patterson has been reliable, converting key field goals and extra points. The return game, led by Kalif Raymond, has provided advantageous field positions, contributing to the offense’s efficiency. Special teams coordinator Dave Fipp has emphasized discipline and execution, resulting in minimal errors and solid performances across all units. As the Lions prepare to host the Bills, their focus will be on maintaining offensive balance and controlling the clock. Establishing the run game early with David Montgomery and Jahmyr Gibbs will be critical to keeping Buffalo’s high-powered offense, led by Josh Allen, off the field. Jared Goff’s ability to make smart decisions and capitalize on scoring opportunities in the red zone will also play a key role. The offensive line, one of the best in the league, must continue its dominance to protect Goff and open running lanes. Defensively, the Lions must prioritize limiting explosive plays from Allen and the Bills’ passing attack. Maintaining gap discipline and containing Allen’s scrambling ability will be crucial, as his mobility can turn broken plays into significant gains. Detroit’s pass rush, led by Aidan Hutchinson, will need to apply consistent pressure to disrupt Allen’s timing and force him into mistakes. The secondary, which has struggled at times, will need to tighten its coverage against Stefon Diggs and the Bills’ talented receiving corps. Special teams will also be an area of emphasis. Winning the field position battle and avoiding costly mistakes in the kicking and return game could swing the momentum in what is expected to be a close contest. The Lions’ attention to detail and execution in this phase could give them an edge in a high-stakes game. For head coach Dan Campbell, the message to his team will be clear: maintain focus and play with the intensity that has defined their season. With the playoffs already secured, the Lions have the opportunity to make a statement against one of the AFC’s elite teams. A win against the Bills would not only solidify their position as a top contender in the NFC but also provide invaluable momentum heading into the postseason. Ultimately, this game represents a chance for the Lions to prove they can compete with and defeat the NFL’s best. If they can execute their game plan effectively on both sides of the ball, Detroit has the talent and confidence to emerge victorious in what promises to be one of the most exciting matchups of the season.

Buffalo vs. Detroit Prop Picks (AI)

Remi is pouring through tons of datapoints on each team. In fact, anytime the Bills and Lions play there’s always several intriguing trends to key in on. Not to mention games played at Ford Field in Dec rarely follow normal, predictable betting trends.
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.

Buffalo vs. Detroit Prediction (AI)

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Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every facet between the Bills and Lions and using recursive machine learning and industry leading AI to analyze the data to a single cover probability.

The Algorithm has been most focused on the trending weight emotional bettors tend to put on coaching factors between a Bills team going up against a possibly tired Lions team. It appears the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Buffalo vs Detroit picks, computer picks Bills vs Lions, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NFL 11/10 PHI@GB UNLOCK THIS PICK 6 VAULT v3 Locked VAULT v3
NFL 11/10 PHI@GB UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 11/10 PHI@GB UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 11/10 PHI@GB UNLOCK THIS PICK 1 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Bills Betting Trends

The Bills have been strong against the spread (ATS) this season, with a 7-6 record overall and 4-2 ATS on the road. Their offense averages 30.5 points per game, often surpassing projected totals.

Lions Betting Trends

The Lions boast an impressive 9-4 ATS record, including 5-2 at home. Their defense allows an average of 18 points per game, contributing to a 1-4 under record in their last five home games.

Bills vs. Lions Matchup Trends

Notably, the over/under for this game is set at 53.5 points, reflecting the high-scoring potential of both teams.

Buffalo vs. Detroit Game Info

Buffalo vs Detroit starts on December 15, 2024 at 5:25 PM EST.

Spread: Detroit -2.5
Moneyline: Buffalo +118, Detroit -140
Over/Under: 54.5

Buffalo: (10-3)  |  Detroit: (12-1)

Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.

Notably, the over/under for this game is set at 53.5 points, reflecting the high-scoring potential of both teams.

BUF trend: The Bills have been strong against the spread (ATS) this season, with a 7-6 record overall and 4-2 ATS on the road. Their offense averages 30.5 points per game, often surpassing projected totals.

DET trend: The Lions boast an impressive 9-4 ATS record, including 5-2 at home. Their defense allows an average of 18 points per game, contributing to a 1-4 under record in their last five home games.

See our latest NFL picks and odds pages for 2024 to compare prices before you bet.

Buffalo vs. Detroit Odds

AI algorithm Remi is pouring through loads of data on each player. In fact, anytime the Buffalo vs Detroit trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable patterns.

Buffalo vs Detroit Opening Odds

BUF Moneyline: +118
DET Moneyline: -140
BUF Spread: +2.5
DET Spread: -2.5
Over/Under: 54.5

Buffalo vs Detroit Live Odds

Games PTS ML SPR O/U
Nov 10, 2025 8:15PM EST
Philadelphia Eagles
Green Bay Packers
11/10/25 8:15PM
Eagles
Packers
-105
-115
-1 (-110)
+1 (-110)
O 45 (-110)
U 45 (-110)
Nov 13, 2025 8:15PM EST
New York Jets
New England Patriots
11/13/25 8:15PM
Jets
Patriots
+550
-850
+12 (-110)
-12 (-110)
O 43 (-115)
U 43 (-105)
Nov 16, 2025 9:30AM EST
Washington Commanders
Miami Dolphins
11/16/25 9:30AM
Commanders
Dolphins
+130
-150
+2.5 (+100)
-2.5 (-120)
O 47.5 (-110)
U 47.5 (-110)
Nov 16, 2025 1:00PM EST
Carolina Panthers
Atlanta Falcons
11/16/25 1PM
Panthers
Falcons
+165
-195
+3.5 (-115)
-3.5 (-105)
O 42.5 (-110)
U 42.5 (-110)
Nov 16, 2025 1:00PM EST
Chicago Bears
Minnesota Vikings
11/16/25 1PM
Bears
Vikings
+140
-165
+3 (-110)
-3 (-110)
O 48 (-110)
U 48 (-110)
Nov 16, 2025 1:00PM EST
Los Angeles Chargers
Jacksonville Jaguars
11/16/25 1PM
Chargers
Jaguars
-150
+130
-3 (+100)
+3 (-120)
O 44 (-110)
U 44 (-110)
Nov 16, 2025 1:00PM EST
Green Bay Packers
New York Giants
11/16/25 1PM
Packers
Giants
-460
+360
-7.5 (-120)
+7.5 (-102)
O 44.5 (-110)
U 44.5 (-110)
Nov 16, 2025 1:00PM EST
Cincinnati Bengals
Pittsburgh Steelers
11/16/25 1PM
Bengals
Steelers
+205
-245
+5.5 (-110)
-5.5 (-110)
O 49.5 (-110)
U 49.5 (-110)
Nov 16, 2025 1:00PM EST
Tampa Bay Buccaneers
Buffalo Bills
11/16/25 1PM
Buccaneers
Bills
+225
-275
+5.5 (-110)
-5.5 (-110)
O 49.5 (-110)
U 49.5 (-110)
Nov 16, 2025 1:00PM EST
Houston Texans
Tennessee Titans
11/16/25 1PM
Texans
Titans
-370
+285
-7 (-110)
+7 (-110)
O 39.5 (-105)
U 39.5 (-115)
Nov 16, 2025 4:05PM EST
San Francisco 49ers
Arizona Cardinals
11/16/25 4:05PM
49ers
Cardinals
-150
+130
-2.5 (-120)
+2.5 (+100)
O 49 (-115)
U 49 (-105)
Nov 16, 2025 4:05PM EST
Seattle Seahawks
Los Angeles Rams
11/16/25 4:05PM
Seahawks
Rams
+130
-150
+2.5 (+100)
-2.5 (-120)
O 48 (-115)
U 48 (-105)
Nov 16, 2025 4:25PM EST
Kansas City Chiefs
Denver Broncos
11/16/25 4:25PM
Chiefs
Broncos
-210
+175
-4 (-110)
+4 (-110)
O 44.5 (-115)
U 44.5 (-105)
Nov 16, 2025 4:25PM EST
Baltimore Ravens
Cleveland Browns
11/16/25 4:25PM
Ravens
Browns
-470
+345
-8 (-110)
+8 (-110)
O 41.5 (-115)
U 41.5 (-105)
Nov 16, 2025 8:20PM EST
Detroit Lions
Philadelphia Eagles
11/16/25 8:20PM
Lions
Eagles
+104
-122
+1.5 (-112)
-1.5 (-108)
O 48.5 (-110)
U 48.5 (-110)
Nov 17, 2025 8:15PM EST
Dallas Cowboys
Las Vegas Raiders
11/17/25 8:15PM
Cowboys
Raiders
-185
+160
-3.5 (+100)
+3.5 (-120)
O 50 (-110)
U 50 (-110)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Buffalo Bills vs. Detroit Lions on December 15, 2024 at Ford Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
LV@DEN RILEY MOSS OVER 4.5 TACKLE + ASST 54.8% 4 WIN
LV@DEN UNDER 43 53.4% 2 WIN
ARI@DAL BUDDA BAKER OVER 7.5 TACKLES + ASSTS 54.4% 4 WIN
ARI@DAL GEORGE PICKENS OVER 4.5 RECEPTIONS 56.6% 6 WIN
DEN@HOU WIL LUTZ OVER 1.5 MADE FIELD GOALS 54.2% 3 LOSS
SEA@WAS SEA -3 56.7% 6 WIN
IND@PIT IND -3 56.8% 6 LOSS
LAC@TEN LAC -9.5 56.2% 6 LOSS
CHI@CIN CHI -2.5 52.6% 2 WIN
SEA@WAS OVER 48 52.9% 2 WIN
SEA@WAS JAYDEN DANIELS OVER 20.5 PASS COMP 56.7% 6 LOSS
JAC@LV JAC -140 64.2% 7 WIN
NO@LAR LAR -14 55.0% 4 WIN
DEN@HOU HOU -1.5 54.2% 3 LOSS
CAR@GB GB -12.5 55.4% 5 LOSS
SF@NYG NYG +2.5 56.1% 5 LOSS
BAL@MIA TUA TAGOVAILOA UNDER 0.5 INT 55.3% 5 LOSS
TB@NO TB -3.5 52.3% 1 WIN
GB@PIT GB -2.5 52.3% 1 WIN
SF@HOU SF +2.5 56.0% 6 LOSS
NYG@PHI NYG +7.5 53.9% 3 LOSS
BUF@CAR CAR +7.5 54.2% 3 LOSS
DAL@DEN DAL +3.5 55.0% 4 LOSS
MIA@ATL MIA +7 54.3% 4 WIN
CLE@NE CLE +7 56.8% 6 LOSS
TB@NO BAKER MAYFIELD OVER 15.5 RUSH YDS 56.6% 6 LOSS
MIN@LAC JUSTIN HERBERT PASS ATT UNDER 35.5 55.5% 5 WIN
TB@DET TB +6.5 54.4% 4 LOSS
TB@DET RACHAAD WHITE UNDER 14.5 RUSH ATT 54.4% 4 WIN
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS