Bills vs Lions Prediction — AI Finds CAN'T MISS NFL Lines & Props (Dec 15)
Updated: 2024-12-08T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Buffalo Bills (10-3) will face the Detroit Lions (12-1) on December 15, 2024, at Ford Field in Detroit. This highly anticipated matchup features two of the NFL’s top offenses, both vying for favorable playoff positioning.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Dec 15, 2024
Start Time: 5:25 PM EST
Venue: Ford Field
Lions Record: (12-1)
Bills Record: (10-3)
OPENING ODDS
BUF Moneyline: +118
DET Moneyline: -140
BUF Spread: +2.5
DET Spread: -2.5
Over/Under: 54.5
BUF
Betting Trends
- The Bills have been strong against the spread (ATS) this season, with a 7-6 record overall and 4-2 ATS on the road. Their offense averages 30.5 points per game, often surpassing projected totals.
DET
Betting Trends
- The Lions boast an impressive 9-4 ATS record, including 5-2 at home. Their defense allows an average of 18 points per game, contributing to a 1-4 under record in their last five home games.
MATCHUP TRENDS
- Notably, the over/under for this game is set at 53.5 points, reflecting the high-scoring potential of both teams.
BUF vs. DET
Best Prop Bet
- Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.
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Buffalo vs Detroit Prediction & Odds:
Free NFL Betting Insights for 12/15/24
Their offense averages 30.5 points per game, second only to the Lions. Quarterback Josh Allen is having an MVP-caliber season, accounting for a significant portion of the team’s offensive production. In a recent game against the Los Angeles Rams, Allen threw for 342 yards and three touchdowns, and rushed for 82 yards with three additional scores. The Bills’ defense, however, has been inconsistent, allowing 20.6 points per game and ranking 14th in total defense. Their pass defense is stronger, ranking ninth, but the run defense lags at 19th. Special teams could play a pivotal role in this matchup. The Lions’ special teams have been strong, with reliable kicking and effective return units. Conversely, the Bills have faced challenges, including critical coaching mistakes and special teams errors in recent games. Betting lines reflect the competitiveness of this game. The Lions opened as 2.5-point favorites, with an over/under set at 53.5 points, indicating expectations of a high-scoring affair. The Bills’ recent performance as road underdogs and the Lions’ strong home record add layers of intrigue for bettors. In summary, this game features two high-powered offenses and defenses with distinct strengths and weaknesses. The outcome may hinge on which defense can make critical stops and how effectively each team manages turnovers. With both teams eyeing favorable playoff positioning, fans can anticipate an intense and closely contested battle at Ford Field.
The HEARTS Act has passed!
— Buffalo Bills (@BuffaloBills) December 11, 2024
Learn more about how this law will provide access to AEDs and CPR education in schools: https://t.co/ZS3DJVOwXi pic.twitter.com/HY8ZS4jrI8
Buffalo Bills NFL Preview
The Buffalo Bills, with a 10-3 record, travel to Detroit to face the 12-1 Lions in a highly anticipated Week 15 matchup. The Bills, sitting atop the AFC East, are in a strong position to secure a playoff spot but face a tough challenge against a Lions team that has been dominant this season. Head coach Sean McDermott has emphasized the importance of maintaining focus and executing at a high level as his team prepares for one of its biggest tests of the season. Offensively, the Bills are a juggernaut, averaging 30.5 points per game, second in the NFL. Quarterback Josh Allen is having an MVP-caliber season, accounting for over 4,200 total yards and 38 touchdowns (32 passing, 6 rushing). Allen’s ability to make plays both through the air and on the ground makes him one of the most difficult players to defend in the league. Wide receiver Stefon Diggs leads the team with 1,214 receiving yards and 10 touchdowns, while rookie tight end Dalton Kincaid has emerged as a reliable target in the red zone. The Bills’ running game, while not the focal point of their offense, has been effective when called upon. James Cook has led the backfield with 728 rushing yards and four touchdowns, providing balance and complementing Allen’s mobility. The offensive line has been solid in pass protection, allowing Allen the time he needs to exploit defenses. However, the Bills’ offensive success has occasionally been hindered by turnovers, an area they will need to clean up against a disciplined Lions defense. Defensively, the Bills rank 14th in the league, allowing 20.6 points per game. Their pass defense has been a strength, ranking ninth and conceding just 209.5 yards per game through the air. However, the run defense has been less consistent, allowing 112.3 yards per game, ranking 19th. The absence of Von Miller, who has been limited by injuries, has impacted their pass rush, though Greg Rousseau and Ed Oliver have stepped up to provide pressure on opposing quarterbacks. The Bills’ secondary, led by Tre’Davious White and Jordan Poyer, has been opportunistic, forcing 14 interceptions this season. The defense’s ability to create turnovers and disrupt Detroit’s offensive rhythm will be critical in this game. Containing Jared Goff and limiting the effectiveness of the Lions’ potent rushing attack will be the primary focus for McDermott and his defensive staff. Special teams have been a mixed bag for Buffalo. Kicker Tyler Bass has been reliable from short distances but has struggled from beyond 50 yards. The return game, led by Deonte Harty, has provided occasional sparks but has not been a consistent factor. The Bills will need a clean performance from their special teams unit to avoid giving the Lions any additional opportunities. As the Bills prepare for this pivotal matchup, their focus will be on playing mistake-free football and capitalizing on scoring opportunities. A win in Detroit would solidify their position in the AFC playoff race and serve as a statement victory against one of the NFL’s best teams. If Buffalo can execute its game plan effectively, the Bills have the talent and experience to prevail in this marquee matchup.

Credit: USA TODAY/IMAGN
Detroit Lions NFL Preview
The Detroit Lions, boasting a 12-1 record, have emerged as one of the NFL’s premier teams in the 2024 season. Under head coach Dan Campbell’s leadership, the Lions have secured a postseason berth and are focused on maintaining their momentum as they host the Buffalo Bills in Week 15. Offensively, the Lions lead the league with an average of 32.1 points per game. Quarterback Jared Goff has been a catalyst, passing for over 3,200 yards and maintaining a high passer rating. His command of the offense and ability to distribute the ball effectively have been key to the team’s success. The running back duo of David Montgomery and rookie Jahmyr Gibbs has been formidable, contributing to the team’s 151.1 rushing yards per game, ranking fourth in the NFL. Montgomery’s power running complements Gibbs’ speed and agility, creating a balanced and dynamic ground attack. Wide receiver Amon-Ra St. Brown leads the receiving corps with 863 yards, providing a reliable target and demonstrating exceptional route-running and hands. Defensively, the Lions have been impressive, allowing just 18 points per game, the second-best mark in the league. Their run defense is particularly strong, conceding only 94.9 yards per game, ranking fifth. This stout run defense forces opponents into passing situations, allowing the Lions’ pass rush to capitalize. However, the pass defense has been a point of concern, allowing 227.2 yards per game, ranking 25th. Injuries have impacted the defensive line, with key players like Alim McNeill potentially sidelined. The anticipated return of DJ Reader could bolster the front line, providing much-needed depth and experience. Linebacker Alex Anzalone has been a leader on defense, orchestrating plays and contributing significantly in tackles. Special teams have been a consistent asset for the Lions. Kicker Riley Patterson has been reliable, converting key field goals and extra points. The return game, led by Kalif Raymond, has provided advantageous field positions, contributing to the offense’s efficiency. Special teams coordinator Dave Fipp has emphasized discipline and execution, resulting in minimal errors and solid performances across all units. As the Lions prepare to host the Bills, their focus will be on maintaining offensive balance and controlling the clock. Establishing the run game early with David Montgomery and Jahmyr Gibbs will be critical to keeping Buffalo’s high-powered offense, led by Josh Allen, off the field. Jared Goff’s ability to make smart decisions and capitalize on scoring opportunities in the red zone will also play a key role. The offensive line, one of the best in the league, must continue its dominance to protect Goff and open running lanes. Defensively, the Lions must prioritize limiting explosive plays from Allen and the Bills’ passing attack. Maintaining gap discipline and containing Allen’s scrambling ability will be crucial, as his mobility can turn broken plays into significant gains. Detroit’s pass rush, led by Aidan Hutchinson, will need to apply consistent pressure to disrupt Allen’s timing and force him into mistakes. The secondary, which has struggled at times, will need to tighten its coverage against Stefon Diggs and the Bills’ talented receiving corps. Special teams will also be an area of emphasis. Winning the field position battle and avoiding costly mistakes in the kicking and return game could swing the momentum in what is expected to be a close contest. The Lions’ attention to detail and execution in this phase could give them an edge in a high-stakes game. For head coach Dan Campbell, the message to his team will be clear: maintain focus and play with the intensity that has defined their season. With the playoffs already secured, the Lions have the opportunity to make a statement against one of the AFC’s elite teams. A win against the Bills would not only solidify their position as a top contender in the NFC but also provide invaluable momentum heading into the postseason. Ultimately, this game represents a chance for the Lions to prove they can compete with and defeat the NFL’s best. If they can execute their game plan effectively on both sides of the ball, Detroit has the talent and confidence to emerge victorious in what promises to be one of the most exciting matchups of the season.
Among all @NFL punters this season, @Lions P @MrJackFox ranks:
— Detroit Lions PR (@LionsPR) December 11, 2024
- 1st in net punting average (46.3)
- 3rd in gross punting average (50.7)
- 6th in percentage of punts pinned inside the 20 (51.3%)#ProBowlVote#OnePride pic.twitter.com/qZEv7uztzs
Buffalo vs. Detroit Prop Picks (AI)
Buffalo vs. Detroit Prediction (AI)

Remi, our AI sports algorithm, has been pouring over tons of data from every angle between the Bills and Lions and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.
The Algorithm has been most keyed in on the linear correlation of weight human bettors tend to put on Detroit’s strength factors between a Bills team going up against a possibly healthy Lions team. We’ve found the true game analytics appear to reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Buffalo vs Detroit picks, computer picks Bills vs Lions, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 5 |
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NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 1 |
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NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 0 |
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NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Bills Betting Trends
The Bills have been strong against the spread (ATS) this season, with a 7-6 record overall and 4-2 ATS on the road. Their offense averages 30.5 points per game, often surpassing projected totals.
Lions Betting Trends
The Lions boast an impressive 9-4 ATS record, including 5-2 at home. Their defense allows an average of 18 points per game, contributing to a 1-4 under record in their last five home games.
Bills vs. Lions Matchup Trends
Notably, the over/under for this game is set at 53.5 points, reflecting the high-scoring potential of both teams.
Buffalo vs. Detroit Game Info
What time does Buffalo vs Detroit start on December 15, 2024?
Buffalo vs Detroit starts on December 15, 2024 at 5:25 PM EST.
Where is Buffalo vs Detroit being played?
Venue: Ford Field.
What are the opening odds for Buffalo vs Detroit?
Spread: Detroit -2.5
Moneyline: Buffalo +118, Detroit -140
Over/Under: 54.5
What are the records for Buffalo vs Detroit?
Buffalo: (10-3) | Detroit: (12-1)
What is the AI best bet for Buffalo vs Detroit?
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.
What are Buffalo vs Detroit trending bets?
Notably, the over/under for this game is set at 53.5 points, reflecting the high-scoring potential of both teams.
What are Buffalo trending bets?
BUF trend: The Bills have been strong against the spread (ATS) this season, with a 7-6 record overall and 4-2 ATS on the road. Their offense averages 30.5 points per game, often surpassing projected totals.
What are Detroit trending bets?
DET trend: The Lions boast an impressive 9-4 ATS record, including 5-2 at home. Their defense allows an average of 18 points per game, contributing to a 1-4 under record in their last five home games.
Where can I find AI Picks for Buffalo vs Detroit?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
Buffalo vs. Detroit Odds
AI algorithm Remi is pouring through loads of stats on each player. In fact, anytime the Buffalo vs Detroit trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable betting trends.
Buffalo vs Detroit Opening Odds
BUF Moneyline:
+118 DET Moneyline: -140
BUF Spread: +2.5
DET Spread: -2.5
Over/Under: 54.5
Buffalo vs Detroit Live Odds
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–
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+148
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O 44.5 (-110)
U 44.5 (-110)
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Patriots
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+270
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-7 (-110)
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O 40.5 (-110)
U 40.5 (-110)
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Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
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Bills
Panthers
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–
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-463
+321
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-7.5 (-110)
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O 46 (-110)
U 46 (-110)
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10/26/25 1PM
Jets
Bengals
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–
–
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+242
-330
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+7 (-110)
-7 (-110)
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O 44.5 (-110)
U 44.5 (-110)
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Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
|
–
–
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+229
-315
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+6.5 (+100)
-6.5 (-120)
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O 50.5 (-110)
U 50.5 (-110)
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Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
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–
–
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+287
-407
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+7 (-110)
-7 (-110)
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O 43.5 (-110)
U 43.5 (-110)
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Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
|
–
–
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-110
-116
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+1 (-110)
-1 (-110)
|
O 41.5 (-110)
U 41.5 (-110)
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Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
|
–
–
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+257
-355
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+7 (-110)
-7 (-110)
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O 44.5 (-110)
U 44.5 (-110)
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Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
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–
–
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-220
+169
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-4.5 (-110)
+4.5 (-110)
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O 47 (-110)
U 47 (-110)
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Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
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–
–
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+141
-181
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+3.5 (-120)
-3.5 (+100)
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O 50 (-110)
U 50 (-110)
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Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
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–
–
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+682
-1442
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+14 (-110)
-14 (-110)
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O 47 (-110)
U 47 (-110)
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Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
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–
–
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-192
+148
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-3.5 (+100)
+3.5 (-120)
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O 44.5 (-110)
U 44.5 (-110)
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Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
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–
–
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+390
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+10.5 (-110)
-10.5 (-110)
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O 47.5 (-110)
U 47.5 (-110)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Buffalo Bills vs. Detroit Lions on December 15, 2024 at Ford Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
GB@ARI | ARI +7 | 54.8% | 5 | WIN |
NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
DET@CIN | DET -10 | 55.6% | 5 | WIN |
DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
PIT@NE | PIT -116 | 60.1% | 6 | WIN |
ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
LV@WAS | LV +3 | 54.3% | 4 | LOSS |