Rams vs 49ers Prediction — AI Finds CAN'T MISS NFL Lines & Props (Dec 12)
Updated: 2024-12-05T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Los Angeles Rams will face the San Francisco 49ers on Thursday, December 12, 2024, at Levi’s Stadium in Santa Clara, California. This NFC West showdown carries significant playoff implications, as both teams are vying for postseason berths.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Dec 12, 2024
Start Time: 9:15 PM EST
Venue: Levi's Stadium
49ers Record: (6-7)
Rams Record: (7-6)
OPENING ODDS
LAR Moneyline: +120
SF Moneyline: -142
LAR Spread: +2.5
SF Spread: -2.5
Over/Under: 49
LAR
Betting Trends
- The Rams have struggled against the spread (ATS) in recent matchups with the 49ers, failing to cover in their last five home games against San Francisco. This trend suggests challenges when hosting their division rival.
SF
Betting Trends
- Conversely, the 49ers have been strong ATS, covering in 10 of their last 12 games overall. They’ve also dominated this specific matchup, going 7-0 ATS in their last seven games against the Rams.
MATCHUP TRENDS
- An interesting ATS statistic is that the total has gone UNDER in five of the Rams’ last seven games against the 49ers, indicating that these encounters often result in lower-scoring affairs.
LAR vs. SF
Best Prop Bet
- Remi's searched hard and found the perfect prop for this matchup: Kyren Williams Over 1.5 Receptions
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Los Angeles vs San Francisco Prediction & Odds:
Free NFL Betting Insights for 12/12/24
After snapping a losing streak with a dominant win over the Chicago Bears, they’ll be looking to maintain that momentum against their divisional rivals. San Francisco has faced its fair share of challenges, particularly with injuries to key offensive players like Christian McCaffrey and Deebo Samuel. Brock Purdy, the young quarterback who captured the league’s attention last season, has experienced growing pains but remains a capable playmaker when given time and space. The offensive line has seen its share of struggles due to injuries, but the return of key players like Aaron Banks could stabilize their performance. Defensively, the 49ers are as fierce as ever, with Fred Warner leading a unit that thrives on disrupting opposing offenses. Their ability to pressure quarterbacks and shut down the run has kept them competitive, even in games where their offense has sputtered. Special teams have also been a strong point for the 49ers, with big plays and consistent execution helping them gain an edge in field position battles. This matchup is not only about tactics but also about pride. The 49ers have had the upper hand in recent meetings, including an impressive 7-0 ATS record against the Rams in their last seven games. However, the Rams will be eager to flip the script and prove they can overcome the 49ers’ physical dominance. Expect a hard-fought game that will likely come down to execution in the trenches, turnover margins, and which team can capitalize on high-leverage situations. With playoff hopes on the line, this game has all the makings of a classic NFC West battle.
🗣️MUST SEE TV! pic.twitter.com/T8QsHsxDNq
— Los Angeles Rams (@RamsNFL) December 11, 2024
Los Angeles Rams NFL Preview
The Los Angeles Rams enter this crucial Week 15 matchup with a 7-6 record, fresh off a thrilling 44-42 victory over the Buffalo Bills. This win has propelled them into the thick of the playoff race, with the team controlling its own destiny as the season approaches its climax. However, the Rams’ journey has been marred by injuries, particularly in their receiving corps and offensive line, which have tested the team’s depth and resilience. Quarterback Matthew Stafford has been a stabilizing force for the offense, showcasing his veteran leadership and playmaking ability. Despite the revolving door of personnel around him, Stafford has maintained a high level of performance, keeping the Rams competitive in a tightly contested NFC West. The emergence of wide receiver Tutu Atwell has been a bright spot, especially in the absence of key players like Cooper Kupp and Puka Nacua. Atwell’s ability to stretch the field and make critical catches has added a new dimension to the Rams’ aerial attack. The running game, led by Kyren Williams, has provided balance to the offense. Williams’ versatility as both a runner and receiver out of the backfield has been instrumental, particularly in light of the team’s injury challenges. His knack for finding the end zone, as evidenced by multiple touchdown performances, has alleviated some pressure off Stafford and the passing game. Defensively, the Rams have faced their share of adversity. The potential absence of cornerback Cobie Durant, who sustained a lung contusion in the recent win over the Bills, could leave a significant void in the secondary. Head coach Sean McVay has indicated that Durant’s status is uncertain for the upcoming game, which may necessitate increased roles for players like Emmanuel Forbes Jr., recently acquired from the Washington Commanders. The defense’s ability to adapt and integrate new contributors will be pivotal against a 49ers offense that has found its rhythm. Special teams have also played a crucial role in the Rams’ recent success. A game-changing blocked punt against the Bills underscored the unit’s impact, directly contributing to the team’s victory. Such plays have not only shifted momentum but have also highlighted the importance of all three phases working in unison. Looking ahead, the Rams are acutely aware of the challenges posed by the 49ers. San Francisco’s physical style of play and recent resurgence make them a formidable opponent. The Rams’ coaching staff is likely emphasizing the need for discipline, execution, and capitalizing on opportunities, especially given the team’s recent ATS struggles against the 49ers. Securing a win on Thursday night would not only bolster the Rams’ playoff aspirations but also serve as a statement within the division.

Credit: USA TODAY/IMAGN
San Francisco 49ers NFL Preview
The San Francisco 49ers approach this pivotal Week 15 clash with a 6-7 record, having recently snapped a two-game losing streak with a commanding 38-13 victory over the Chicago Bears. This win has rekindled their playoff hopes, but the team remains in a precarious position, trailing the NFC West-leading Seattle Seahawks by two games. The upcoming matchup against the Rams is critical, as a victory would not only improve their standing but also provide a significant morale boost. Offensively, the 49ers have been navigating a series of injuries to key players. Running back Christian McCaffrey has been dealing with a calf issue, while wide receiver Deebo Samuel’s production has been below expectations, partly due to defensive adjustments by opponents. Tight end George Kittle has acknowledged these challenges but remains optimistic about Samuel’s potential impact in the upcoming game. Quarterback Brock Purdy has shown resilience, taking accountability for missed opportunities and demonstrating growth in his decision-making. The offensive line has faced its own set of challenges, with players like Trent Williams and Aaron Banks dealing with injuries, though Banks has recently cleared concussion protocols and is expected to return. Defensively, the 49ers have been a formidable unit, consistently applying pressure on opposing quarterbacks and maintaining a strong presence against the run. Linebacker Fred Warner has been a vocal leader, emphasizing the team’s sense of urgency and the need for cohesive efforts to turn the season around. The secondary has also been tested, with injuries to players like Tashaun Gipson Sr. and Ambry Thomas, necessitating adjustments and the elevation of depth players into more prominent roles. Special teams have contributed positively, with strategic plays that have shifted momentum in critical moments. The coaching staff, led by head coach Kyle Shanahan, has been proactive in addressing the team’s challenges, including restructuring contracts to manage the salary cap effectively, as seen with Javon Hargrave’s recent contract adjustment. This financial maneuvering has provided the team with greater flexibility moving forward. The 49ers’ recent history against the Rams has been favorable, with the team covering the spread in 10 of their last 12 games and maintaining a 7-0 ATS record in their last seven matchups against Los Angeles. This trend reflects the team’s preparedness and execution in divisional games, particularly against the Rams. However, the 49ers are not complacent, recognizing the Rams’ recent form and the high stakes of the upcoming game. In preparation for Thursday night’s game, the 49ers are focusing on maintaining their physical style of play and limiting turnovers, which have been a recurring issue in close games. The team understands that controlling the line of scrimmage and winning the battle in the trenches will be key, especially against a Rams defensive front anchored by Aaron Donald. The 49ers’ home-field advantage at Levi’s Stadium is expected to play a significant role, with a passionate fan base providing a hostile environment for their division rival. The team has historically thrived under the bright lights of primetime games, and Shanahan’s track record in these situations suggests the 49ers will be well-prepared for this critical showdown. Ultimately, the 49ers are approaching this game with a heightened sense of urgency, knowing that a win could significantly boost their playoff chances while reaffirming their dominance over the Rams in recent matchups. Their focus on execution, health, and maintaining a balanced attack on both sides of the ball will be crucial as they look to keep their postseason dreams alive.
This is proof that Fred stays on 💯
— San Francisco 49ers (@49ers) December 11, 2024
Mic'd Up powered by @Cisco. pic.twitter.com/19Wa6mMLj1
Los Angeles vs. San Francisco Prop Picks (AI)
Los Angeles vs. San Francisco Prediction (AI)

Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every facet between the Rams and 49ers and using recursive machine learning and impressive AI to analyze the data to a single cover probability.
Remi has been most fixated on the linear correlation of emphasis human bettors tend to put on coaching factors between a Rams team going up against a possibly strong 49ers team. We’ve found the true game analytics might reflect a moderate lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Los Angeles vs San Francisco picks, computer picks Rams vs 49ers, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 5 |
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NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 1 |
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NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 0 |
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NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Rams Betting Trends
The Rams have struggled against the spread (ATS) in recent matchups with the 49ers, failing to cover in their last five home games against San Francisco. This trend suggests challenges when hosting their division rival.
49ers Betting Trends
Conversely, the 49ers have been strong ATS, covering in 10 of their last 12 games overall. They’ve also dominated this specific matchup, going 7-0 ATS in their last seven games against the Rams.
Rams vs. 49ers Matchup Trends
An interesting ATS statistic is that the total has gone UNDER in five of the Rams’ last seven games against the 49ers, indicating that these encounters often result in lower-scoring affairs.
Los Angeles vs. San Francisco Game Info
What time does Los Angeles vs San Francisco start on December 12, 2024?
Los Angeles vs San Francisco starts on December 12, 2024 at 9:15 PM EST.
Where is Los Angeles vs San Francisco being played?
Venue: Levi's Stadium.
What are the opening odds for Los Angeles vs San Francisco?
Spread: San Francisco -2.5
Moneyline: Los Angeles +120, San Francisco -142
Over/Under: 49
What are the records for Los Angeles vs San Francisco?
Los Angeles: (7-6) | San Francisco: (6-7)
What is the AI best bet for Los Angeles vs San Francisco?
Remi's searched hard and found the perfect prop for this matchup: Kyren Williams Over 1.5 Receptions. Prices move—always shop for the best number.
What are Los Angeles vs San Francisco trending bets?
An interesting ATS statistic is that the total has gone UNDER in five of the Rams’ last seven games against the 49ers, indicating that these encounters often result in lower-scoring affairs.
What are Los Angeles trending bets?
LAR trend: The Rams have struggled against the spread (ATS) in recent matchups with the 49ers, failing to cover in their last five home games against San Francisco. This trend suggests challenges when hosting their division rival.
What are San Francisco trending bets?
SF trend: Conversely, the 49ers have been strong ATS, covering in 10 of their last 12 games overall. They’ve also dominated this specific matchup, going 7-0 ATS in their last seven games against the Rams.
Where can I find AI Picks for Los Angeles vs San Francisco?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
Los Angeles vs. San Francisco Odds
Remi is pouring through loads of data points on each team. In fact, anytime the Los Angeles vs San Francisco trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme altitude can often follow normal, predictable patterns.
Los Angeles vs San Francisco Opening Odds
LAR Moneyline:
+120 SF Moneyline: -142
LAR Spread: +2.5
SF Spread: -2.5
Over/Under: 49
Los Angeles vs San Francisco Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 23, 2025 8:15PM EDT
Minnesota Vikings
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10/23/25 8:15PM
Vikings
Chargers
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–
–
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+142
-165
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+3 (-110)
-3 (-110)
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O 45 (-110)
U 45 (-110)
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Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
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–
–
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+290
-360
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+7 (-110)
-7 (-110)
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O 40.5 (-110)
U 40.5 (-110)
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Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
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–
–
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-400
+320
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-7.5 (-110)
+7.5 (-110)
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O 45.5 (-110)
U 45.5 (-110)
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Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
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–
–
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+250
-300
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+6.5 (-105)
-6.5 (-115)
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O 44.5 (-105)
U 44.5 (-115)
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Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
|
–
–
|
+265
-325
|
+7 (-120)
-7 (+100)
|
O 50 (-110)
U 50 (-110)
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Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
|
–
–
|
+290
-360
|
+7 (-105)
-7 (-115)
|
O 43.5 (-115)
U 43.5 (-105)
|
|
Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
|
–
–
|
-110
-106
|
-1.5 (-104)
+1.5 (-118)
|
O 41.5 (-115)
U 41.5 (-105)
|
|
Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
|
–
–
|
+280
-350
|
+7 (-110)
-7 (-110)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
|
–
–
|
-220
+184
|
-4.5 (-112)
+4.5 (-108)
|
O 47.5 (-105)
U 47.5 (-115)
|
|
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
|
–
–
|
+146
-170
|
+3 (+100)
-3 (-120)
|
O 49.5 (-110)
U 49.5 (-110)
|
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Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
|
–
–
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+750
-1200
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+14 (-110)
-14 (-110)
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O 47 (-110)
U 47 (-110)
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Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
|
–
–
|
-185
+159
|
-3.5 (-105)
+3.5 (-115)
|
O 45 (-113)
U 45 (-107)
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Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
|
–
–
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+465
-630
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+10.5 (-115)
-10.5 (-105)
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O 48.5 (-110)
U 48.5 (-110)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Los Angeles Rams vs. San Francisco 49ers on December 12, 2024 at Levi's Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
GB@ARI | ARI +7 | 54.8% | 5 | WIN |
NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
DET@CIN | DET -10 | 55.6% | 5 | WIN |
DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
PIT@NE | PIT -116 | 60.1% | 6 | WIN |
ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
LV@WAS | LV +3 | 54.3% | 4 | LOSS |