Rams vs. 49ers
Prediction, Odds & Props
Dec 12 | NFL AI Picks

Updated: 2024-12-05T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Los Angeles Rams will face the San Francisco 49ers on Thursday, December 12, 2024, at Levi’s Stadium in Santa Clara, California. This NFC West showdown carries significant playoff implications, as both teams are vying for postseason berths.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Dec 12, 2024

Start Time: 9:15 PM EST​

Venue: Levi's Stadium​

49ers Record: (6-7)

Rams Record: (7-6)

OPENING ODDS

LAR Moneyline: +120

SF Moneyline: -142

LAR Spread: +2.5

SF Spread: -2.5

Over/Under: 49

LAR
Betting Trends

  • The Rams have struggled against the spread (ATS) in recent matchups with the 49ers, failing to cover in their last five home games against San Francisco. This trend suggests challenges when hosting their division rival.

SF
Betting Trends

  • Conversely, the 49ers have been strong ATS, covering in 10 of their last 12 games overall. They’ve also dominated this specific matchup, going 7-0 ATS in their last seven games against the Rams.

MATCHUP TRENDS

  • An interesting ATS statistic is that the total has gone UNDER in five of the Rams’ last seven games against the 49ers, indicating that these encounters often result in lower-scoring affairs.

LAR vs. SF
Best Prop Bet

  • Remi's searched hard and found the perfect prop for this matchup: Kyren Williams Over 1.5 Receptions

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Los Angeles vs San Francisco Prediction & Odds:
Free NFL Betting Insights for 12/12/24

The Los Angeles Rams and San Francisco 49ers meet on December 12, 2024, in what promises to be a thrilling NFC West showdown at Levi’s Stadium. This primetime matchup carries significant playoff implications for both teams as they battle for divisional supremacy and postseason positioning. The Rams enter the contest with a slightly better record, sitting at 7-6, while the 49ers, at 6-7, are clawing their way back into the playoff picture after a turbulent season. These two teams have a storied rivalry, and their recent encounters have been marked by high intensity, strategic chess matches between coaches Sean McVay and Kyle Shanahan, and a consistent display of physical football. This game will be no different as both teams are fighting for more than just bragging rights—they’re fighting for their seasons. The Rams come into this game with momentum after an exhilarating victory over the Buffalo Bills, a game that showcased their resilience and ability to make game-changing plays in critical moments. However, injuries remain a significant concern, particularly in the secondary and among their skill position players. Quarterback Matthew Stafford has been steady and reliable, often carrying the team on his back with precision passing and leadership. On offense, players like Tutu Atwell and Kyren Williams have stepped up to fill the void left by injuries, providing Stafford with capable weapons to exploit opposing defenses. The Rams’ defense, led by perennial All-Pro Aaron Donald, continues to be the backbone of the team, though lapses in consistency have occasionally made them vulnerable. On the other side, the 49ers have been fighting through a season of ups and downs.

After snapping a losing streak with a dominant win over the Chicago Bears, they’ll be looking to maintain that momentum against their divisional rivals. San Francisco has faced its fair share of challenges, particularly with injuries to key offensive players like Christian McCaffrey and Deebo Samuel. Brock Purdy, the young quarterback who captured the league’s attention last season, has experienced growing pains but remains a capable playmaker when given time and space. The offensive line has seen its share of struggles due to injuries, but the return of key players like Aaron Banks could stabilize their performance. Defensively, the 49ers are as fierce as ever, with Fred Warner leading a unit that thrives on disrupting opposing offenses. Their ability to pressure quarterbacks and shut down the run has kept them competitive, even in games where their offense has sputtered. Special teams have also been a strong point for the 49ers, with big plays and consistent execution helping them gain an edge in field position battles. This matchup is not only about tactics but also about pride. The 49ers have had the upper hand in recent meetings, including an impressive 7-0 ATS record against the Rams in their last seven games. However, the Rams will be eager to flip the script and prove they can overcome the 49ers’ physical dominance. Expect a hard-fought game that will likely come down to execution in the trenches, turnover margins, and which team can capitalize on high-leverage situations. With playoff hopes on the line, this game has all the makings of a classic NFC West battle.

Los Angeles Rams NFL Preview

The Los Angeles Rams enter this crucial Week 15 matchup with a 7-6 record, fresh off a thrilling 44-42 victory over the Buffalo Bills. This win has propelled them into the thick of the playoff race, with the team controlling its own destiny as the season approaches its climax. However, the Rams’ journey has been marred by injuries, particularly in their receiving corps and offensive line, which have tested the team’s depth and resilience. Quarterback Matthew Stafford has been a stabilizing force for the offense, showcasing his veteran leadership and playmaking ability. Despite the revolving door of personnel around him, Stafford has maintained a high level of performance, keeping the Rams competitive in a tightly contested NFC West. The emergence of wide receiver Tutu Atwell has been a bright spot, especially in the absence of key players like Cooper Kupp and Puka Nacua. Atwell’s ability to stretch the field and make critical catches has added a new dimension to the Rams’ aerial attack. The running game, led by Kyren Williams, has provided balance to the offense. Williams’ versatility as both a runner and receiver out of the backfield has been instrumental, particularly in light of the team’s injury challenges. His knack for finding the end zone, as evidenced by multiple touchdown performances, has alleviated some pressure off Stafford and the passing game. Defensively, the Rams have faced their share of adversity. The potential absence of cornerback Cobie Durant, who sustained a lung contusion in the recent win over the Bills, could leave a significant void in the secondary. Head coach Sean McVay has indicated that Durant’s status is uncertain for the upcoming game, which may necessitate increased roles for players like Emmanuel Forbes Jr., recently acquired from the Washington Commanders. The defense’s ability to adapt and integrate new contributors will be pivotal against a 49ers offense that has found its rhythm. Special teams have also played a crucial role in the Rams’ recent success. A game-changing blocked punt against the Bills underscored the unit’s impact, directly contributing to the team’s victory. Such plays have not only shifted momentum but have also highlighted the importance of all three phases working in unison. Looking ahead, the Rams are acutely aware of the challenges posed by the 49ers. San Francisco’s physical style of play and recent resurgence make them a formidable opponent. The Rams’ coaching staff is likely emphasizing the need for discipline, execution, and capitalizing on opportunities, especially given the team’s recent ATS struggles against the 49ers. Securing a win on Thursday night would not only bolster the Rams’ playoff aspirations but also serve as a statement within the division.

The Los Angeles Rams will face the San Francisco 49ers on Thursday, December 12, 2024, at Levi’s Stadium in Santa Clara, California. This NFC West showdown carries significant playoff implications, as both teams are vying for postseason berths. Los Angeles vs San Francisco AI Prediction: Free NFL Betting Insights for Dec 12. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Francisco 49ers NFL Preview

The San Francisco 49ers approach this pivotal Week 15 clash with a 6-7 record, having recently snapped a two-game losing streak with a commanding 38-13 victory over the Chicago Bears. This win has rekindled their playoff hopes, but the team remains in a precarious position, trailing the NFC West-leading Seattle Seahawks by two games. The upcoming matchup against the Rams is critical, as a victory would not only improve their standing but also provide a significant morale boost. Offensively, the 49ers have been navigating a series of injuries to key players. Running back Christian McCaffrey has been dealing with a calf issue, while wide receiver Deebo Samuel’s production has been below expectations, partly due to defensive adjustments by opponents. Tight end George Kittle has acknowledged these challenges but remains optimistic about Samuel’s potential impact in the upcoming game. Quarterback Brock Purdy has shown resilience, taking accountability for missed opportunities and demonstrating growth in his decision-making. The offensive line has faced its own set of challenges, with players like Trent Williams and Aaron Banks dealing with injuries, though Banks has recently cleared concussion protocols and is expected to return. Defensively, the 49ers have been a formidable unit, consistently applying pressure on opposing quarterbacks and maintaining a strong presence against the run. Linebacker Fred Warner has been a vocal leader, emphasizing the team’s sense of urgency and the need for cohesive efforts to turn the season around. The secondary has also been tested, with injuries to players like Tashaun Gipson Sr. and Ambry Thomas, necessitating adjustments and the elevation of depth players into more prominent roles. Special teams have contributed positively, with strategic plays that have shifted momentum in critical moments. The coaching staff, led by head coach Kyle Shanahan, has been proactive in addressing the team’s challenges, including restructuring contracts to manage the salary cap effectively, as seen with Javon Hargrave’s recent contract adjustment. This financial maneuvering has provided the team with greater flexibility moving forward. The 49ers’ recent history against the Rams has been favorable, with the team covering the spread in 10 of their last 12 games and maintaining a 7-0 ATS record in their last seven matchups against Los Angeles. This trend reflects the team’s preparedness and execution in divisional games, particularly against the Rams. However, the 49ers are not complacent, recognizing the Rams’ recent form and the high stakes of the upcoming game. In preparation for Thursday night’s game, the 49ers are focusing on maintaining their physical style of play and limiting turnovers, which have been a recurring issue in close games. The team understands that controlling the line of scrimmage and winning the battle in the trenches will be key, especially against a Rams defensive front anchored by Aaron Donald. The 49ers’ home-field advantage at Levi’s Stadium is expected to play a significant role, with a passionate fan base providing a hostile environment for their division rival. The team has historically thrived under the bright lights of primetime games, and Shanahan’s track record in these situations suggests the 49ers will be well-prepared for this critical showdown. Ultimately, the 49ers are approaching this game with a heightened sense of urgency, knowing that a win could significantly boost their playoff chances while reaffirming their dominance over the Rams in recent matchups. Their focus on execution, health, and maintaining a balanced attack on both sides of the ball will be crucial as they look to keep their postseason dreams alive.

Los Angeles vs. San Francisco Prop Picks (AI)

AI algorithm Remi is pouring through tons of stats on each team. In fact, anytime the Rams and 49ers play there’s always several intriguing angles to key in on. Not to mention games played at Levi's Stadium in Dec can often follow normal, predictable betting trends.
Remi's searched hard and found the perfect prop for this matchup: Kyren Williams Over 1.5 Receptions

Los Angeles vs. San Francisco Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over mountains of data from every past game between the Rams and 49ers and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.

The Algorithm has been most watching on the unproportionally assigned factor knucklehead sportsbettors regularly put on coaching factors between a Rams team going up against a possibly rested 49ers team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Los Angeles vs San Francisco picks, computer picks Rams vs 49ers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Rams Betting Trends

The Rams have struggled against the spread (ATS) in recent matchups with the 49ers, failing to cover in their last five home games against San Francisco. This trend suggests challenges when hosting their division rival.

49ers Betting Trends

Conversely, the 49ers have been strong ATS, covering in 10 of their last 12 games overall. They’ve also dominated this specific matchup, going 7-0 ATS in their last seven games against the Rams.

Rams vs. 49ers Matchup Trends

An interesting ATS statistic is that the total has gone UNDER in five of the Rams’ last seven games against the 49ers, indicating that these encounters often result in lower-scoring affairs.

Los Angeles vs. San Francisco Game Info

Los Angeles vs San Francisco starts on December 12, 2024 at 9:15 PM EST.

Spread: San Francisco -2.5
Moneyline: Los Angeles +120, San Francisco -142
Over/Under: 49

Los Angeles: (7-6)  |  San Francisco: (6-7)

Remi's searched hard and found the perfect prop for this matchup: Kyren Williams Over 1.5 Receptions. Prices move—always shop for the best number.

An interesting ATS statistic is that the total has gone UNDER in five of the Rams’ last seven games against the 49ers, indicating that these encounters often result in lower-scoring affairs.

LAR trend: The Rams have struggled against the spread (ATS) in recent matchups with the 49ers, failing to cover in their last five home games against San Francisco. This trend suggests challenges when hosting their division rival.

SF trend: Conversely, the 49ers have been strong ATS, covering in 10 of their last 12 games overall. They’ve also dominated this specific matchup, going 7-0 ATS in their last seven games against the Rams.

See our latest NFL picks and odds pages for 2024 to compare prices before you bet.

Los Angeles vs. San Francisco Odds

AI algorithm Remi is pouring through loads of data points on each player. In fact, anytime the Los Angeles vs San Francisco trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable patterns.

Los Angeles vs San Francisco Opening Odds

LAR Moneyline: +120
SF Moneyline: -142
LAR Spread: +2.5
SF Spread: -2.5
Over/Under: 49

Los Angeles vs San Francisco Live Odds

Games PTS ML SPR O/U
Sep 28, 2025 9:31AM EDT
Minnesota Vikings
Pittsburgh Steelers
9/28/25 9:31AM
Vikings
Steelers
-140
+115
-2.5 (-115)
+2.5 (-105)
O 41 (-110)
U 41 (-110)
Sep 28, 2025 1:00PM EDT
Cleveland Browns
Detroit Lions
9/28/25 1PM
Browns
Lions
+400
-550
+10 (-110)
-10 (-110)
O 44.5 (-105)
U 44.5 (-115)
Sep 28, 2025 1:00PM EDT
Los Angeles Chargers
New York Giants
9/28/25 1PM
Chargers
Giants
-285
+230
-6.5 (-105)
+6.5 (-115)
O 44 (-110)
U 44 (-110)
Sep 28, 2025 1:01PM EDT
Tennessee Titans
Houston Texans
9/28/25 1:01PM
Titans
Texans
+300
-375
+7 (-105)
-7 (-115)
O 39 (-110)
U 39 (-110)
Sep 28, 2025 1:01PM EDT
Philadelphia Eagles
Tampa Bay Buccaneers
9/28/25 1:01PM
Eagles
Buccaneers
-190
+160
-3.5 (-105)
+3.5 (-115)
O 44 (-110)
U 44 (-110)
Sep 28, 2025 1:01PM EDT
Washington Commanders
Atlanta Falcons
9/28/25 1:01PM
Commanders
Falcons
+110
-130
+2 (-110)
-2 (-110)
O 43.5 (-110)
U 43.5 (-110)
Sep 28, 2025 1:01PM EDT
New Orleans Saints
Buffalo Bills
9/28/25 1:01PM
Saints
Bills
+800
-1300
+15 (-110)
-15 (-110)
O 48 (-110)
U 48 (-110)
Sep 28, 2025 1:01PM EDT
Carolina Panthers
New England Patriots
9/28/25 1:01PM
Panthers
Patriots
+200
-250
+5.5 (-110)
-5.5 (-110)
O 43 (-110)
U 43 (-110)
Sep 28, 2025 4:06PM EDT
Jacksonville Jaguars
San Francisco 49ers
9/28/25 4:06PM
Jaguars
49ers
+150
-180
+3.5 (-115)
-3.5 (-105)
O 46.5 (-110)
U 46.5 (-110)
Sep 28, 2025 4:06PM EDT
Indianapolis Colts
Los Angeles Rams
9/28/25 4:06PM
Colts
Rams
+160
-190
+3.5 (-110)
-3.5 (-110)
O 49.5 (-110)
U 49.5 (-110)
Sep 28, 2025 4:25PM EDT
Baltimore Ravens
Kansas City Chiefs
9/28/25 4:25PM
Ravens
Chiefs
-150
+125
-2.5 (-120)
+2.5 (+100)
O 48.5 (-110)
U 48.5 (-110)
Sep 28, 2025 4:26PM EDT
Chicago Bears
Las Vegas Raiders
9/28/25 4:26PM
Bears
Raiders
+100
-120
+1 (-110)
-1 (-110)
O 48 (-110)
U 48 (-110)
Sep 28, 2025 8:21PM EDT
Green Bay Packers
Dallas Cowboys
9/28/25 8:21PM
Packers
Cowboys
-325
+250
-7 (-105)
+7 (-115)
O 47 (-110)
U 47 (-110)
Sep 29, 2025 7:15PM EDT
New York Jets
Miami Dolphins
9/29/25 7:15PM
Jets
Dolphins
+125
-150
+3 (-115)
-3 (-105)
O 44.5 (-110)
U 44.5 (-110)
Sep 29, 2025 8:15PM EDT
Cincinnati Bengals
Denver Broncos
9/29/25 8:15PM
Bengals
Broncos
+310
-400
+7.5 (-110)
-7.5 (-110)
O 44 (-110)
U 44 (-110)
Oct 2, 2025 8:16PM EDT
San Francisco 49ers
Los Angeles Rams
10/2/25 8:16PM
49ers
Rams
+134
-158
+3 (-105)
-3 (-115)
O 47 (-110)
U 47 (-110)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Los Angeles Rams vs. San Francisco 49ers on December 12, 2024 at Levi's Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
SEA@ARI SEA -125 57.7% 6 WIN
SEA@ARI KYLER MURRAY TO THROW AN INT 56.6% 6 WIN
DET@BAL JAHMYR GIBBS OVER 0.5 RUSH TDS 55.8% 5 WIN
DAL@CHI DAL -120 58.7% 6 LOSS
PIT@NE PIT -116 60.1% 6 WIN
ATL@CAR ATL -4.5 55.4% 5 LOSS
LV@WAS LV +3 54.3% 4 LOSS
GB@CLE GB -7 54.3% 4 LOSS
ARI@SF ARI +3 57.7% 6 WIN
KC@NYG PATRICK MAHOMES OVER 230.5 PASS YDS 54.7% 4 WIN
GB@CLE JOE FLACCO OVER 37.5 PASS ATT 56.6% 6 LOSS
MIA@BUF TYREEK HILL OVER 5.5 TOTAL RECEPTIONS 56.8% 6 LOSS
LAC@LV LAC -3 54.9% 4 WIN
TB@HOU BAKER MAYFIELD OVER 1.5 PASS TDS 54.4% 4 WIN
CHI@DET DET -6.5 54.3% 4 WIN
DEN@IND DEN -118 60.1% 10 LOSS
PHI@KC PHI -115 56.7% 6 WIN
SF@NO SF -3 58.8% 8 WIN
SEA@PIT OVER 40 54.9% 4 WIN
CAR@ARI BRYCE YOUNG INTERCEPTIONS UNDER 0.5 56.4% 6 LOSS
DEN@IND JOSH DOWNS RECEPTIONS OVER 3.5 54.7% 4 WIN
ATL@MIN BIJAN ROBINSON RUSH + REC YDS OVER 94.5 53.4% 3 WIN
WAS@GB WAS +3.5 56.5% 6 LOSS
WAS@GB JORDAN LOVE OVER 5.5 RUSH YDS 54.7% 4 WIN
MIN@CHI CALEB WILLIAMS OVER 219.5 PASS YDS 53.4% 3 LOSS
TEN@DEN DEN -8.5 55.3% 5 LOSS
SF@SEA SF -115 54.6% 4 WIN
SF@SEA KENNETH WALKER III UNDER 79.5 RUSH+REC YDS 54.6% 4 WIN
CAR@JAC TANK BIGSBY OVER 10.5 RUSH ATT 56.1% 6 LOSS
KC@LAC JUSTIN HERBERT UNDER 0.5 INT 54.1% 3 WIN
DAL@PHI GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS 54.1% 4 LOSS
KC@PHI JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS 53.90% 5 WIN
KC@PHI DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS 54.40% 6 WIN
KC@PHI PATRICK MAHOMES UNDER 68.3% PASS COMP 55.00% 8 WIN
KC@PHI JALEN HURTS LONGEST RUSH OVER 12.5 YDS 55.60% 8 WIN
BUF@KC DALTON KINCAID OVER 29.5 RECV YDS 55.10% 8 LOSS
WAS@PHI DEVONTA SMITH OVER 3.5 RECEPTIONS 55.80% 8 WIN
BUF@KC JAMES COOK ANYTIME TD 53.00% 5 WIN
LAR@PHI SAQUON BARKLEY UNDER 128 RUSH + REC YDS 53.20% 5 LOSS
BAL@BUF LAMAR JACKSON OVER 54.5 RUSH YDS 54.50% 6 LOSS
HOU@KC C.J. STROUD RUSH YDS UNDER 14.5 53.10% 5 LOSS
WAS@DET JAMESON WILLIAMS RUSH YDS OVER 1.5 53.30% 5 WIN
WAS@DET JARED GOFF PASS COMP % UNDER 72.3 54.30% 6 WIN
MIN@LAR COOPER KUPP ANYTIME TOUCHDOWN 52.60% 3 LOSS
MIN@LAR MATTHEW STAFFORD OVER 21.5 PASS COMP 54.10% 6 LOSS
WAS@TB BRIAN ROBINSON JR OVER 1.5 REC TARGETS 53.50% 5 WIN
WAS@TB BAKER MAYFIELD UNDER 33.5 PASS ATT 54.90% 6 WIN
GB@PHI JALEN HURTS OVER 67.1 PASS COMP PERCENTAGE 54.60% 6 LOSS
LAC@HOU J.K. DOBBINS ANYTIME TD 52.80% 3 LOSS
LAC@HOU LAC -2.5 53.40% 3 LOSS
LAC@HOU JUSTIN HERBERT OVER 19.5 RUSH YDS 53.40% 5 LOSS