49ers vs Bills Prediction — AI Finds CAN'T MISS NFL Lines & Props (Dec 01)
Updated: 2024-11-24T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The San Francisco 49ers (5-6) are set to face the Buffalo Bills (9-2) on December 1, 2024, at Highmark Stadium in Orchard Park, New York. This Week 13 matchup features the 49ers aiming to rebound from recent losses, while the Bills seek to maintain their strong position atop the AFC East.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Dec 01, 2024
Start Time: 9:20 PM EST
Venue: Highmark Stadium
Bills Record: (9-2)
49ers Record: (5-6)
OPENING ODDS
SF Moneyline: +251
BUF Moneyline: -314
SF Spread: +7
BUF Spread: -7.0
Over/Under: 44.5
SF
Betting Trends
- The 49ers have struggled against the spread (ATS) this season, holding a 4-7 record. Their average margin of defeat is 6.5 points, indicating challenges in both offense and defense. Notably, they have failed to cover the spread in their last three games, highlighting ongoing difficulties.
BUF
Betting Trends
- The Bills have been more successful ATS, with a 7-4 record. Their average margin of victory is 8.2 points, reflecting a tendency to win by more than a touchdown. At home, they have covered the spread in four of their five games, showcasing a strong performance in front of their fans.
MATCHUP TRENDS
- An interesting ATS statistic for this game is the Bills being favored by 6.5 points, despite the 49ers’ recent struggles. The over/under is set at 45.5 points, suggesting expectations of a moderately high-scoring game. Bettors should note the Bills’ strong ATS performance at home and the 49ers’ challenges in covering spreads this season.
SF vs. BUF
Best Prop Bet
- Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.
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San Francisco vs Buffalo Prediction & Odds:
Free NFL Betting Insights for 12/1/24
Quarterback Josh Allen continues to be a dual-threat, leading an offense that ranks among the league’s best in both passing and rushing yards. Defensively, the Bills have been formidable, allowing an average of 18.5 points per game, showcasing their ability to stifle opposing offenses. The weather conditions in Orchard Park are expected to be challenging, with forecasts predicting heavy lake-effect snow and temperatures that could feel like single digits due to 30 mph winds. These conditions may favor the Bills, who are more accustomed to playing in harsh weather. This game not only has significant playoff implications but also serves as a test of resilience and adaptability for both teams.
A disclaimer from @gkittle46 ⚠️
— San Francisco 49ers (@49ers) November 27, 2024
Watch the full Mic'd Up powered by @Cisco here: https://t.co/WfUn52SmI0. pic.twitter.com/GVXpqKBOVx
San Francisco 49ers NFL Preview
The San Francisco 49ers approach this game with a 5-6 record, placing them in a precarious position as they strive to keep their playoff hopes alive. Their recent 38-10 loss to the Green Bay Packers exposed several areas of concern, particularly on defense, where they struggled to contain the Packers’ offensive onslaught. The uncertainty surrounding quarterback Brock Purdy’s shoulder injury adds to their challenges, potentially impacting their offensive rhythm. The running game, traditionally a strength, has been inconsistent, placing additional pressure on the passing attack. Defensively, the 49ers have allowed an average of 24.7 points per game, indicating vulnerabilities that need to be addressed. The upcoming game against the Bills, especially under challenging weather conditions, will test their resilience and adaptability. A victory would not only boost their confidence but also keep their playoff aspirations within reach.
Credit: USA TODAY/IMAGN
Buffalo Bills NFL Preview
The Buffalo Bills enter this matchup with a 9-2 record, leading the AFC East and showcasing one of the most balanced teams in the league. Quarterback Josh Allen continues to be a dynamic playmaker, contributing significantly to an offense that averages 28.3 points per game. The running game, led by Devin Singletary and complemented by Allen’s mobility, adds a versatile dimension to their offensive strategy. Defensively, the Bills have been stout, allowing just 18.5 points per game, ranking among the league’s best. Their ability to generate pressure with the front four has been instrumental in disrupting opposing quarterbacks. The upcoming game against the 49ers presents an opportunity to solidify their position atop the division and continue their pursuit of a top seed in the playoffs. The anticipated harsh weather conditions may play to their advantage, given their familiarity with playing in such environments.
SNF in Orchard Park.
— Buffalo Bills (@BuffaloBills) November 26, 2024
REPOST for your chance to be there!!https://t.co/55qeTjwzLm | #BillsMafia pic.twitter.com/AVzwxtGcJu
San Francisco vs. Buffalo Prop Picks (AI)
San Francisco vs. Buffalo Prediction (AI)
Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every angle between the 49ers and Bills and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.
The Algorithm has been most keyed in on the unproportionally assigned emphasis human bettors regularly put on San Francisco’s strength factors between a 49ers team going up against a possibly healthy Bills team. Trends look to say the true game analytics appear to reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI San Francisco vs Buffalo picks, computer picks 49ers vs Bills, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 5 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 1 |
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| NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 0 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
49ers Betting Trends
The 49ers have struggled against the spread (ATS) this season, holding a 4-7 record. Their average margin of defeat is 6.5 points, indicating challenges in both offense and defense. Notably, they have failed to cover the spread in their last three games, highlighting ongoing difficulties.
Bills Betting Trends
The Bills have been more successful ATS, with a 7-4 record. Their average margin of victory is 8.2 points, reflecting a tendency to win by more than a touchdown. At home, they have covered the spread in four of their five games, showcasing a strong performance in front of their fans.
49ers vs. Bills Matchup Trends
An interesting ATS statistic for this game is the Bills being favored by 6.5 points, despite the 49ers’ recent struggles. The over/under is set at 45.5 points, suggesting expectations of a moderately high-scoring game. Bettors should note the Bills’ strong ATS performance at home and the 49ers’ challenges in covering spreads this season.
San Francisco vs. Buffalo Game Info
What time does San Francisco vs Buffalo start on December 01, 2024?
San Francisco vs Buffalo starts on December 01, 2024 at 9:20 PM EST.
Where is San Francisco vs Buffalo being played?
Venue: Highmark Stadium.
What are the opening odds for San Francisco vs Buffalo?
Spread: Buffalo -7.0
Moneyline: San Francisco +251, Buffalo -314
Over/Under: 44.5
What are the records for San Francisco vs Buffalo?
San Francisco: (5-6) | Buffalo: (9-2)
What is the AI best bet for San Francisco vs Buffalo?
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.
What are San Francisco vs Buffalo trending bets?
An interesting ATS statistic for this game is the Bills being favored by 6.5 points, despite the 49ers’ recent struggles. The over/under is set at 45.5 points, suggesting expectations of a moderately high-scoring game. Bettors should note the Bills’ strong ATS performance at home and the 49ers’ challenges in covering spreads this season.
What are San Francisco trending bets?
SF trend: The 49ers have struggled against the spread (ATS) this season, holding a 4-7 record. Their average margin of defeat is 6.5 points, indicating challenges in both offense and defense. Notably, they have failed to cover the spread in their last three games, highlighting ongoing difficulties.
What are Buffalo trending bets?
BUF trend: The Bills have been more successful ATS, with a 7-4 record. Their average margin of victory is 8.2 points, reflecting a tendency to win by more than a touchdown. At home, they have covered the spread in four of their five games, showcasing a strong performance in front of their fans.
Where can I find AI Picks for San Francisco vs Buffalo?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
San Francisco vs. Buffalo Odds
AI algorithm Remi is pouring through mountains of stats on each team. In fact, anytime the San Francisco vs Buffalo trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable patterns.
San Francisco vs Buffalo Opening Odds
SF Moneyline:
+251 BUF Moneyline: -314
SF Spread: +7
BUF Spread: -7.0
Over/Under: 44.5
San Francisco vs Buffalo Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Oct 23, 2025 8:15PM EDT
Minnesota Vikings
Los Angeles Chargers
10/23/25 8:15PM
Vikings
Chargers
|
–
–
|
+133
-167
|
+3 (-114)
-3 (-112)
|
O 44.5 (-113)
U 44.5 (-113)
|
|
|
Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
|
–
–
|
+265
-375
|
+7 (-118)
-7 (-108)
|
O 40.5 (-109)
U 40.5 (-117)
|
|
|
Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
|
–
–
|
-500
+340
|
-7.5 (-115)
+7.5 (-110)
|
O 46.5 (-112)
U 46.5 (-113)
|
|
|
Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
|
–
–
|
+235
-315
|
+6.5 (-112)
-6.5 (-114)
|
O 44 (-109)
U 44 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
|
–
–
|
+260
-360
|
+6.5 (-110)
-6.5 (-115)
|
O 50 (-115)
U 50 (-109)
|
|
|
Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
|
–
–
|
+275
-385
|
+7 (-113)
-7 (-113)
|
O 43 (-114)
U 43 (-112)
|
|
|
Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
|
–
–
|
-109
-117
|
+1 (-115)
-1 (-109)
|
O 41 (-115)
U 41 (-110)
|
|
|
Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
|
–
–
|
+295
-420
|
+7 (-108)
-7 (-118)
|
O 44.5 (-113)
U 44.5 (-113)
|
|
|
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
|
–
–
|
-245
+185
|
-4.5 (-115)
+4.5 (-110)
|
O 47.5 (-109)
U 47.5 (-117)
|
|
|
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
|
–
–
|
+135
-175
|
+3.5 (-118)
-3.5 (-108)
|
O 50 (-109)
U 50 (-117)
|
|
|
Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
|
–
–
|
+650
-1250
|
+14 (-108)
-14 (-118)
|
O 47 (-113)
U 47 (-113)
|
|
|
Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
|
–
–
|
-177
+135
|
-3 (-113)
+3 (-113)
|
O 45 (-112)
U 45 (-113)
|
|
|
Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
|
–
–
|
+420
-670
|
+10.5 (-114)
-10.5 (-112)
|
O 48 (-113)
U 48 (-113)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Francisco 49ers vs. Buffalo Bills on December 01, 2024 at Highmark Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
| CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
| PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
| GB@ARI | ARI +7 | 54.8% | 5 | WIN |
| NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
| WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
| GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
| PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
| BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
| CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
| TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
| DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
| SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
| LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
| ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
| TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
| LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
| SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
| CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
| DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
| KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
| KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
| HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
| DET@CIN | DET -10 | 55.6% | 5 | WIN |
| DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
| TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
| TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
| DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
| MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
| LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
| SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
| NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
| CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
| NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
| CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
| NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
| CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
| WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
| BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
| TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
| LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
| NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
| GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
| CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |