49ers vs. Bills
Prediction, Odds & Props
Dec 01 | NFL AI Picks
Updated: 2024-11-24T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The San Francisco 49ers (5-6) are set to face the Buffalo Bills (9-2) on December 1, 2024, at Highmark Stadium in Orchard Park, New York. This Week 13 matchup features the 49ers aiming to rebound from recent losses, while the Bills seek to maintain their strong position atop the AFC East.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Dec 01, 2024
Start Time: 9:20 PM EST
Venue: Highmark Stadium
Bills Record: (9-2)
49ers Record: (5-6)
OPENING ODDS
SF Moneyline: +251
BUF Moneyline: -314
SF Spread: +7
BUF Spread: -7.0
Over/Under: 44.5
SF
Betting Trends
- The 49ers have struggled against the spread (ATS) this season, holding a 4-7 record. Their average margin of defeat is 6.5 points, indicating challenges in both offense and defense. Notably, they have failed to cover the spread in their last three games, highlighting ongoing difficulties.
BUF
Betting Trends
- The Bills have been more successful ATS, with a 7-4 record. Their average margin of victory is 8.2 points, reflecting a tendency to win by more than a touchdown. At home, they have covered the spread in four of their five games, showcasing a strong performance in front of their fans.
MATCHUP TRENDS
- An interesting ATS statistic for this game is the Bills being favored by 6.5 points, despite the 49ers’ recent struggles. The over/under is set at 45.5 points, suggesting expectations of a moderately high-scoring game. Bettors should note the Bills’ strong ATS performance at home and the 49ers’ challenges in covering spreads this season.
SF vs. BUF
Best Prop Bet
- Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.
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San Francisco vs Buffalo Prediction & Odds:
Free NFL Betting Insights for 12/1/24
Quarterback Josh Allen continues to be a dual-threat, leading an offense that ranks among the league’s best in both passing and rushing yards. Defensively, the Bills have been formidable, allowing an average of 18.5 points per game, showcasing their ability to stifle opposing offenses. The weather conditions in Orchard Park are expected to be challenging, with forecasts predicting heavy lake-effect snow and temperatures that could feel like single digits due to 30 mph winds. These conditions may favor the Bills, who are more accustomed to playing in harsh weather. This game not only has significant playoff implications but also serves as a test of resilience and adaptability for both teams.
A disclaimer from @gkittle46 ⚠️
— San Francisco 49ers (@49ers) November 27, 2024
Watch the full Mic'd Up powered by @Cisco here: https://t.co/WfUn52SmI0. pic.twitter.com/GVXpqKBOVx
San Francisco 49ers NFL Preview
The San Francisco 49ers approach this game with a 5-6 record, placing them in a precarious position as they strive to keep their playoff hopes alive. Their recent 38-10 loss to the Green Bay Packers exposed several areas of concern, particularly on defense, where they struggled to contain the Packers’ offensive onslaught. The uncertainty surrounding quarterback Brock Purdy’s shoulder injury adds to their challenges, potentially impacting their offensive rhythm. The running game, traditionally a strength, has been inconsistent, placing additional pressure on the passing attack. Defensively, the 49ers have allowed an average of 24.7 points per game, indicating vulnerabilities that need to be addressed. The upcoming game against the Bills, especially under challenging weather conditions, will test their resilience and adaptability. A victory would not only boost their confidence but also keep their playoff aspirations within reach.
Credit: USA TODAY/IMAGN
Buffalo Bills NFL Preview
The Buffalo Bills enter this matchup with a 9-2 record, leading the AFC East and showcasing one of the most balanced teams in the league. Quarterback Josh Allen continues to be a dynamic playmaker, contributing significantly to an offense that averages 28.3 points per game. The running game, led by Devin Singletary and complemented by Allen’s mobility, adds a versatile dimension to their offensive strategy. Defensively, the Bills have been stout, allowing just 18.5 points per game, ranking among the league’s best. Their ability to generate pressure with the front four has been instrumental in disrupting opposing quarterbacks. The upcoming game against the 49ers presents an opportunity to solidify their position atop the division and continue their pursuit of a top seed in the playoffs. The anticipated harsh weather conditions may play to their advantage, given their familiarity with playing in such environments.
SNF in Orchard Park.
— Buffalo Bills (@BuffaloBills) November 26, 2024
REPOST for your chance to be there!!https://t.co/55qeTjwzLm | #BillsMafia pic.twitter.com/AVzwxtGcJu
San Francisco vs. Buffalo Prop Picks (AI)
San Francisco vs. Buffalo Prediction (AI)
Remi, our AI sports wizard, has been pouring over tons of data from every past game between the 49ers and Bills and using recursive machine learning and industry leading AI to examine the data to a single cover probability.
Remi has been most watching on the trending emphasis knucklehead sportsbettors often put on coaching factors between a 49ers team going up against a possibly healthy Bills team. In reality, the true game analytics might reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI San Francisco vs Buffalo picks, computer picks 49ers vs Bills, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
49ers Betting Trends
The 49ers have struggled against the spread (ATS) this season, holding a 4-7 record. Their average margin of defeat is 6.5 points, indicating challenges in both offense and defense. Notably, they have failed to cover the spread in their last three games, highlighting ongoing difficulties.
Bills Betting Trends
The Bills have been more successful ATS, with a 7-4 record. Their average margin of victory is 8.2 points, reflecting a tendency to win by more than a touchdown. At home, they have covered the spread in four of their five games, showcasing a strong performance in front of their fans.
49ers vs. Bills Matchup Trends
An interesting ATS statistic for this game is the Bills being favored by 6.5 points, despite the 49ers’ recent struggles. The over/under is set at 45.5 points, suggesting expectations of a moderately high-scoring game. Bettors should note the Bills’ strong ATS performance at home and the 49ers’ challenges in covering spreads this season.
San Francisco vs. Buffalo Game Info
What time does San Francisco vs Buffalo start on December 01, 2024?
San Francisco vs Buffalo starts on December 01, 2024 at 9:20 PM EST.
Where is San Francisco vs Buffalo being played?
Venue: Highmark Stadium.
What are the opening odds for San Francisco vs Buffalo?
Spread: Buffalo -7.0
Moneyline: San Francisco +251, Buffalo -314
Over/Under: 44.5
What are the records for San Francisco vs Buffalo?
San Francisco: (5-6) | Buffalo: (9-2)
What is the AI best bet for San Francisco vs Buffalo?
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.
What are San Francisco vs Buffalo trending bets?
An interesting ATS statistic for this game is the Bills being favored by 6.5 points, despite the 49ers’ recent struggles. The over/under is set at 45.5 points, suggesting expectations of a moderately high-scoring game. Bettors should note the Bills’ strong ATS performance at home and the 49ers’ challenges in covering spreads this season.
What are San Francisco trending bets?
SF trend: The 49ers have struggled against the spread (ATS) this season, holding a 4-7 record. Their average margin of defeat is 6.5 points, indicating challenges in both offense and defense. Notably, they have failed to cover the spread in their last three games, highlighting ongoing difficulties.
What are Buffalo trending bets?
BUF trend: The Bills have been more successful ATS, with a 7-4 record. Their average margin of victory is 8.2 points, reflecting a tendency to win by more than a touchdown. At home, they have covered the spread in four of their five games, showcasing a strong performance in front of their fans.
Where can I find AI Picks for San Francisco vs Buffalo?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
San Francisco vs. Buffalo Odds
Remi is pouring through tons of stats on each line. In fact, anytime the San Francisco vs Buffalo trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps can often follow normal, predictable betting trends.
San Francisco vs Buffalo Opening Odds
SF Moneyline:
+251 BUF Moneyline: -314
SF Spread: +7
BUF Spread: -7.0
Over/Under: 44.5
San Francisco vs Buffalo Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Sep 28, 2025 9:31AM EDT
Minnesota Vikings
Pittsburgh Steelers
9/28/25 9:31AM
Vikings
Steelers
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–
–
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-140
+118
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-2.5 (-115)
+2.5 (-105)
|
O 41 (-110)
U 41 (-110)
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|
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Sep 28, 2025 1:00PM EDT
Cleveland Browns
Detroit Lions
9/28/25 1PM
Browns
Lions
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–
–
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+400
-590
|
+10 (-107)
-10 (-112)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Sep 28, 2025 1:00PM EDT
Los Angeles Chargers
New York Giants
9/28/25 1PM
Chargers
Giants
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–
–
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-305
+240
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-6.5 (-105)
+6.5 (-115)
|
O 43.5 (-110)
U 43.5 (-110)
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Sep 28, 2025 1:01PM EDT
Tennessee Titans
Houston Texans
9/28/25 1:01PM
Titans
Texans
|
–
–
|
+295
-400
|
+7 (-108)
-7 (-112)
|
O 39.5 (-106)
U 39.5 (-115)
|
|
|
Sep 28, 2025 1:01PM EDT
Philadelphia Eagles
Tampa Bay Buccaneers
9/28/25 1:01PM
Eagles
Buccaneers
|
–
–
|
-195
+162
|
-3.5 (-110)
+3.5 (-110)
|
O 44 (-110)
U 44 (-110)
|
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Sep 28, 2025 1:01PM EDT
Washington Commanders
Atlanta Falcons
9/28/25 1:01PM
Commanders
Falcons
|
–
–
|
+110
-136
|
+2 (-108)
-2 (-112)
|
O 43.5 (-107)
U 43.5 (-112)
|
|
|
Sep 28, 2025 1:01PM EDT
New Orleans Saints
Buffalo Bills
9/28/25 1:01PM
Saints
Bills
|
–
–
|
+800
-1700
|
+14.5 (-107)
-14.5 (-114)
|
O 48 (-113)
U 48 (-108)
|
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|
Sep 28, 2025 1:01PM EDT
Carolina Panthers
New England Patriots
9/28/25 1:01PM
Panthers
Patriots
|
–
–
|
+195
-245
|
+5.5 (-110)
-5.5 (-109)
|
O 43 (-114)
U 43 (-108)
|
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|
Sep 28, 2025 4:06PM EDT
Jacksonville Jaguars
San Francisco 49ers
9/28/25 4:06PM
Jaguars
49ers
|
–
–
|
+150
-190
|
+3.5 (-120)
-3.5 (+100)
|
O 46.5 (-110)
U 46.5 (-112)
|
|
|
Sep 28, 2025 4:06PM EDT
Indianapolis Colts
Los Angeles Rams
9/28/25 4:06PM
Colts
Rams
|
–
–
|
+158
-190
|
+3.5 (-110)
-3.5 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
|
Sep 28, 2025 4:25PM EDT
Baltimore Ravens
Kansas City Chiefs
9/28/25 4:25PM
Ravens
Chiefs
|
–
–
|
-145
+122
|
-2.5 (-115)
+2.5 (-105)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
|
Sep 28, 2025 4:26PM EDT
Chicago Bears
Las Vegas Raiders
9/28/25 4:26PM
Bears
Raiders
|
–
–
|
+100
-125
|
+1.5 (-108)
-1.5 (-112)
|
O 48 (-113)
U 48 (-108)
|
|
|
Sep 28, 2025 8:21PM EDT
Green Bay Packers
Dallas Cowboys
9/28/25 8:21PM
Packers
Cowboys
|
–
–
|
-355
+278
|
-6.5 (-115)
+6.5 (-105)
|
O 46.5 (-110)
U 46.5 (-110)
|
|
|
Sep 29, 2025 7:15PM EDT
New York Jets
Miami Dolphins
9/29/25 7:15PM
Jets
Dolphins
|
–
–
|
+125
-154
|
+2.5 (-105)
-2.5 (-115)
|
O 44.5 (-113)
U 44.5 (-108)
|
|
|
Sep 29, 2025 8:15PM EDT
Cincinnati Bengals
Denver Broncos
9/29/25 8:15PM
Bengals
Broncos
|
–
–
|
+345
-455
|
+7.5 (-105)
-7.5 (-115)
|
O 44 (-110)
U 44 (-110)
|
|
|
Oct 2, 2025 8:16PM EDT
San Francisco 49ers
Los Angeles Rams
10/2/25 8:16PM
49ers
Rams
|
–
–
|
+134
-158
|
+3 (-110)
-3 (-110)
|
O 47.5 (-110)
U 47.5 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Francisco 49ers vs. Buffalo Bills on December 01, 2024 at Highmark Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |
| GB@CLE | GB -7 | 54.3% | 4 | LOSS |
| ARI@SF | ARI +3 | 57.7% | 6 | WIN |
| KC@NYG | PATRICK MAHOMES OVER 230.5 PASS YDS | 54.7% | 4 | WIN |
| GB@CLE | JOE FLACCO OVER 37.5 PASS ATT | 56.6% | 6 | LOSS |
| MIA@BUF | TYREEK HILL OVER 5.5 TOTAL RECEPTIONS | 56.8% | 6 | LOSS |
| LAC@LV | LAC -3 | 54.9% | 4 | WIN |
| TB@HOU | BAKER MAYFIELD OVER 1.5 PASS TDS | 54.4% | 4 | WIN |
| CHI@DET | DET -6.5 | 54.3% | 4 | WIN |
| DEN@IND | DEN -118 | 60.1% | 10 | LOSS |
| PHI@KC | PHI -115 | 56.7% | 6 | WIN |
| SF@NO | SF -3 | 58.8% | 8 | WIN |
| SEA@PIT | OVER 40 | 54.9% | 4 | WIN |
| CAR@ARI | BRYCE YOUNG INTERCEPTIONS UNDER 0.5 | 56.4% | 6 | LOSS |
| DEN@IND | JOSH DOWNS RECEPTIONS OVER 3.5 | 54.7% | 4 | WIN |
| ATL@MIN | BIJAN ROBINSON RUSH + REC YDS OVER 94.5 | 53.4% | 3 | WIN |
| WAS@GB | WAS +3.5 | 56.5% | 6 | LOSS |
| WAS@GB | JORDAN LOVE OVER 5.5 RUSH YDS | 54.7% | 4 | WIN |
| MIN@CHI | CALEB WILLIAMS OVER 219.5 PASS YDS | 53.4% | 3 | LOSS |
| TEN@DEN | DEN -8.5 | 55.3% | 5 | LOSS |
| SF@SEA | SF -115 | 54.6% | 4 | WIN |
| SF@SEA | KENNETH WALKER III UNDER 79.5 RUSH+REC YDS | 54.6% | 4 | WIN |
| CAR@JAC | TANK BIGSBY OVER 10.5 RUSH ATT | 56.1% | 6 | LOSS |
| KC@LAC | JUSTIN HERBERT UNDER 0.5 INT | 54.1% | 3 | WIN |
| DAL@PHI | GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS | 54.1% | 4 | LOSS |
| KC@PHI | JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS | 53.90% | 5 | WIN |
| KC@PHI | DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS | 54.40% | 6 | WIN |
| KC@PHI | PATRICK MAHOMES UNDER 68.3% PASS COMP | 55.00% | 8 | WIN |
| KC@PHI | JALEN HURTS LONGEST RUSH OVER 12.5 YDS | 55.60% | 8 | WIN |
| BUF@KC | DALTON KINCAID OVER 29.5 RECV YDS | 55.10% | 8 | LOSS |
| WAS@PHI | DEVONTA SMITH OVER 3.5 RECEPTIONS | 55.80% | 8 | WIN |
| BUF@KC | JAMES COOK ANYTIME TD | 53.00% | 5 | WIN |
| LAR@PHI | SAQUON BARKLEY UNDER 128 RUSH + REC YDS | 53.20% | 5 | LOSS |
| BAL@BUF | LAMAR JACKSON OVER 54.5 RUSH YDS | 54.50% | 6 | LOSS |
| HOU@KC | C.J. STROUD RUSH YDS UNDER 14.5 | 53.10% | 5 | LOSS |
| WAS@DET | JAMESON WILLIAMS RUSH YDS OVER 1.5 | 53.30% | 5 | WIN |
| WAS@DET | JARED GOFF PASS COMP % UNDER 72.3 | 54.30% | 6 | WIN |
| MIN@LAR | COOPER KUPP ANYTIME TOUCHDOWN | 52.60% | 3 | LOSS |
| MIN@LAR | MATTHEW STAFFORD OVER 21.5 PASS COMP | 54.10% | 6 | LOSS |
| WAS@TB | BRIAN ROBINSON JR OVER 1.5 REC TARGETS | 53.50% | 5 | WIN |
| WAS@TB | BAKER MAYFIELD UNDER 33.5 PASS ATT | 54.90% | 6 | WIN |
| GB@PHI | JALEN HURTS OVER 67.1 PASS COMP PERCENTAGE | 54.60% | 6 | LOSS |
| LAC@HOU | J.K. DOBBINS ANYTIME TD | 52.80% | 3 | LOSS |
| LAC@HOU | LAC -2.5 | 53.40% | 3 | LOSS |
| LAC@HOU | JUSTIN HERBERT OVER 19.5 RUSH YDS | 53.40% | 5 | LOSS |