Lions vs. Colts
Prediction, Odds & Props
Nov 24 | NFL AI Picks
Updated: 2024-11-17T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
On November 24, 2024, the Detroit Lions (9-1) will visit the Indianapolis Colts (5-6) at Lucas Oil Stadium. The Lions aim to extend their eight-game winning streak, while the Colts seek to build momentum after a recent victory.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Nov 24, 2024
Start Time: 2:00 PM EST​
Venue: Lucas Oil Stadium​
Colts Record: (5-5)
Lions Record: (9-1)
OPENING ODDS
DET Moneyline: -380
IND Moneyline: +301
DET Spread: -7.5
IND Spread: +7.5
Over/Under: 50.5
DET
Betting Trends
- The Lions have been impressive against the spread (ATS) this season, covering in 7 of their last 8 games. Their consistent performance has made them a reliable choice for bettors.
IND
Betting Trends
- The Colts have also performed well ATS, covering in 7 of their last 9 games. Their ability to exceed betting expectations has been notable, especially considering their overall record.
MATCHUP TRENDS
- The Lions are favored by 7.5 points in this matchup. Historically, when favored by more than a touchdown on the road, Detroit has covered the spread in 4 of their last 5 games.
DET vs. IND
Best Prop Bet
- Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.
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Detroit vs Indianapolis Prediction & Odds:
Free NFL Betting Insights for 11/24/24
Quarterback Anthony Richardson returned to the starting lineup and delivered a strong performance, demonstrating maturity following a temporary benching. The Colts’ offense has shown flashes of potential, particularly in the running game, which could be a focal point in this matchup. Defensively, they have been inconsistent, struggling to contain high-powered offenses, which could be a concern against the Lions’ potent attack. Key factors in this game include the Lions’ ability to maintain their offensive efficiency against a Colts defense that has been vulnerable to big plays. The Colts will need to capitalize on any opportunities to exploit the Lions’ defense, particularly through their ground attack. Special teams could also play a crucial role, as field position and clutch kicking may determine the outcome in what is expected to be a closely contested game.
J🔥RED G🔥FF pic.twitter.com/wlczgYDHhr
— Detroit Lions (@Lions) November 19, 2024
Detroit Lions NFL Preview
The Detroit Lions are enjoying a remarkable season, boasting a 9-1 record and an eight-game winning streak. Quarterback Jared Goff has been instrumental in this success, delivering consistent and efficient performances. His connection with the receiving corps, including standout performances from wide receivers Amon-Ra St. Brown and Jameson Williams, has been a cornerstone of the offense. The running game, featuring D’Andre Swift and Jamaal Williams, has provided balance, keeping defenses honest and opening up opportunities in the passing game. Defensively, the Lions have been formidable, with a front seven that excels in applying pressure and stopping the run. The secondary has been opportunistic, contributing to the team’s impressive turnover margin. Special teams have also been a strength, with reliable kicking and punting units, as well as explosive return capabilities that have provided advantageous field positions. The coaching staff has been praised for effective game planning and in-game adjustments, positioning the Lions as strong contenders in the NFC.
Credit: USA TODAY/IMAGN
Indianapolis Colts NFL Preview
The Indianapolis Colts have faced a challenging season, entering this game with a 5-6 record. Injuries and inconsistent play have plagued the team, leading to a series of disappointing performances. However, the recent reinstatement of quarterback Anthony Richardson has injected new life into the offense. Richardson’s dual-threat capability adds a dynamic element, allowing for a more versatile offensive scheme. The running game, led by Jonathan Taylor, has been a bright spot, providing stability and setting up play-action opportunities. Defensively, the Colts have struggled to contain high-powered offenses, particularly in the secondary, which has been susceptible to big plays. The pass rush has been inconsistent, failing to generate the pressure needed to disrupt opposing quarterbacks. Special teams have been reliable, with kicker Rodrigo Blankenship providing consistency in the kicking game. The coaching staff faces the challenge of addressing these issues and formulating a game plan to counter the Lions’ potent offense.
Per Coach Steichen, Tyquan Lewis has been designated to return to practice. pic.twitter.com/GAGb8nGodT
— Indianapolis Colts (@Colts) November 20, 2024
Detroit vs. Indianapolis Prop Picks (AI)
Detroit vs. Indianapolis Prediction (AI)
Remi, our AI sports genius, has been pouring over mountains of data from every simulation between the Lions and Colts and using recursive machine learning and impressive AI to analyze the data to a single cover probability.
Remi has been most watching on the trending emphasis knucklehead sportsbettors often put on Indianapolis’s strength factors between a Lions team going up against a possibly tired Colts team. We’ve found the true game analytics appear to reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Detroit vs Indianapolis picks, computer picks Lions vs Colts, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NFL | 9/28 | LAC@NYG | UNLOCK THIS PICK | 7 |
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| NFL | 9/28 | TEN@HOU | UNLOCK THIS PICK | 7 |
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| NFL | 9/28 | CAR@NE | UNLOCK THIS PICK | 6 |
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| NFL | 9/28 | BAL@KC | UNLOCK THIS PICK | 6 |
VAULT v2
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| NFL | 9/28 | GB@DAL | UNLOCK THIS PICK | 5 |
EXECUTIVE
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| NFL | 9/28 | WAS@ATL | UNLOCK THIS PICK | 4 |
EXECUTIVE
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| NFL | 9/28 | NO@BUF | UNLOCK THIS PICK | 3 |
EXECUTIVE
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| NFL | 9/28 | GB@DAL | UNLOCK THIS PICK | 2 |
INTEL
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| NFL | 9/28 | CHI@LV | GET FREE PICK NOW | 2 | – | |
| NFL | 9/28 | PHI@TB | UNLOCK THIS PICK | 10 |
INTEL
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| NFL | 9/28 | BAL@KC | UNLOCK THIS PICK | 0 |
INTEL
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| NFL | 9/28 | IND@LAR | UNLOCK THIS PICK | 1 |
INTEL
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| NFL | 9/28 | CAR@NE | UNLOCK THIS PICK | 0 |
INTEL
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| NFL | 9/28 | GB@DAL | UNLOCK THIS PICK | 0 |
INTEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Lions Betting Trends
The Lions have been impressive against the spread (ATS) this season, covering in 7 of their last 8 games. Their consistent performance has made them a reliable choice for bettors.
Colts Betting Trends
The Colts have also performed well ATS, covering in 7 of their last 9 games. Their ability to exceed betting expectations has been notable, especially considering their overall record.
Lions vs. Colts Matchup Trends
The Lions are favored by 7.5 points in this matchup. Historically, when favored by more than a touchdown on the road, Detroit has covered the spread in 4 of their last 5 games.
Detroit vs. Indianapolis Game Info
What time does Detroit vs Indianapolis start on November 24, 2024?
Detroit vs Indianapolis starts on November 24, 2024 at 2:00 PM EST.
Where is Detroit vs Indianapolis being played?
Venue: Lucas Oil Stadium.
What are the opening odds for Detroit vs Indianapolis?
Spread: Indianapolis +7.5
Moneyline: Detroit -380, Indianapolis +301
Over/Under: 50.5
What are the records for Detroit vs Indianapolis?
Detroit: (9-1) Â |Â Indianapolis: (5-5)
What is the AI best bet for Detroit vs Indianapolis?
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.
What are Detroit vs Indianapolis trending bets?
The Lions are favored by 7.5 points in this matchup. Historically, when favored by more than a touchdown on the road, Detroit has covered the spread in 4 of their last 5 games.
What are Detroit trending bets?
DET trend: The Lions have been impressive against the spread (ATS) this season, covering in 7 of their last 8 games. Their consistent performance has made them a reliable choice for bettors.
What are Indianapolis trending bets?
IND trend: The Colts have also performed well ATS, covering in 7 of their last 9 games. Their ability to exceed betting expectations has been notable, especially considering their overall record.
Where can I find AI Picks for Detroit vs Indianapolis?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
Detroit vs. Indianapolis Odds
AI algorithm Remi is pouring through mountains of data on each player. In fact, anytime the Detroit vs Indianapolis trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance seemingly never follow normal, predictable patterns.
Detroit vs Indianapolis Opening Odds
DET Moneyline:
-380 IND Moneyline: +301
DET Spread: -7.5
IND Spread: +7.5
Over/Under: 50.5
Detroit vs Indianapolis Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
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In Progress
New Orleans Saints
Buffalo Bills
In Progress
Saints
Bills
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10
14
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+450
-720
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+7.5 (-118)
-7.5 (-112)
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O 54.5 (-125)
U 54.5 (-106)
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In Progress
Philadelphia Eagles
Tampa Bay Buccaneers
In Progress
Eagles
Buccaneers
|
21
3
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-10000
+1700
|
-20.5 (-130)
+20.5 (-102)
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O 47.5 (-102)
U 47.5 (-130)
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|
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In Progress
Cleveland Browns
Detroit Lions
In Progress
Browns
Lions
|
7
17
|
+1060
-3500
|
+15.5 (-118)
-15.5 (-112)
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O 47.5 (-118)
U 47.5 (-112)
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In Progress
Los Angeles Chargers
New York Giants
In Progress
Chargers
Giants
|
3
10
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+180
-235
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+5.5 (-130)
-5.5 (-102)
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O 40.5 (-102)
U 40.5 (-130)
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In Progress
Washington Commanders
Atlanta Falcons
In Progress
Commanders
Falcons
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10
17
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+265
-400
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+6.5 (-109)
-6.5 (-129)
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O 50 (-125)
U 50 (-113)
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In Progress
Tennessee Titans
Houston Texans
In Progress
Titans
Texans
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0
6
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+380
-670
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+7 (-109)
-7 (-129)
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O 27.5 (-115)
U 27.5 (-121)
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In Progress
Carolina Panthers
New England Patriots
In Progress
Panthers
Patriots
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6
21
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+4000
-20000
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+23.5 (-114)
-23.5 (-114)
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O 55.5 (-132)
U 55.5 (+100)
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Sep 28, 2025 4:06PM EDT
Jacksonville Jaguars
San Francisco 49ers
9/28/25 4:06PM
Jaguars
49ers
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–
–
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+142
-168
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+3.5 (-122)
-3.5 (+100)
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O 45.5 (-108)
U 45.5 (-112)
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Sep 28, 2025 4:06PM EDT
Indianapolis Colts
Los Angeles Rams
9/28/25 4:06PM
Colts
Rams
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–
–
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+158
-188
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+3.5 (-115)
-3.5 (-105)
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O 49.5 (-112)
U 49.5 (-108)
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Sep 28, 2025 4:25PM EDT
Baltimore Ravens
Kansas City Chiefs
9/28/25 4:25PM
Ravens
Chiefs
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–
–
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-154
+130
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-2.5 (-120)
+2.5 (-102)
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O 48.5 (-115)
U 48.5 (-105)
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Sep 28, 2025 4:26PM EDT
Chicago Bears
Las Vegas Raiders
9/28/25 4:26PM
Bears
Raiders
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–
–
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+110
-130
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+1.5 (-105)
-1.5 (-115)
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O 47.5 (-118)
U 47.5 (-104)
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Sep 28, 2025 8:21PM EDT
Green Bay Packers
Dallas Cowboys
9/28/25 8:21PM
Packers
Cowboys
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–
–
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-320
+260
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-6.5 (-115)
+6.5 (-105)
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O 46.5 (-112)
U 46.5 (-108)
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Sep 29, 2025 7:16PM EDT
New York Jets
Miami Dolphins
9/29/25 7:16PM
Jets
Dolphins
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–
–
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+132
-156
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+2.5 (-102)
-2.5 (-120)
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O 44.5 (-108)
U 44.5 (-112)
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Sep 29, 2025 8:16PM EDT
Cincinnati Bengals
Denver Broncos
9/29/25 8:16PM
Bengals
Broncos
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–
–
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+360
-460
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+7.5 (-108)
-7.5 (-112)
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O 43.5 (-118)
U 43.5 (-104)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Detroit Lions vs. Indianapolis Colts on November 24, 2024 at Lucas Oil Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
   LEAN |    %WIN |    UNITS | RESULT |
|---|---|---|---|---|
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |
| GB@CLE | GB -7 | 54.3% | 4 | LOSS |
| ARI@SF | ARI +3 | 57.7% | 6 | WIN |
| KC@NYG | PATRICK MAHOMES OVER 230.5 PASS YDS | 54.7% | 4 | WIN |
| GB@CLE | JOE FLACCO OVER 37.5 PASS ATT | 56.6% | 6 | LOSS |
| MIA@BUF | TYREEK HILL OVER 5.5 TOTAL RECEPTIONS | 56.8% | 6 | LOSS |
| LAC@LV | LAC -3 | 54.9% | 4 | WIN |
| TB@HOU | BAKER MAYFIELD OVER 1.5 PASS TDS | 54.4% | 4 | WIN |
| CHI@DET | DET -6.5 | 54.3% | 4 | WIN |
| DEN@IND | DEN -118 | 60.1% | 10 | LOSS |
| PHI@KC | PHI -115 | 56.7% | 6 | WIN |
| SF@NO | SF -3 | 58.8% | 8 | WIN |
| SEA@PIT | OVER 40 | 54.9% | 4 | WIN |
| CAR@ARI | BRYCE YOUNG INTERCEPTIONS UNDER 0.5 | 56.4% | 6 | LOSS |
| DEN@IND | JOSH DOWNS RECEPTIONS OVER 3.5 | 54.7% | 4 | WIN |
| ATL@MIN | BIJAN ROBINSON RUSH + REC YDS OVER 94.5 | 53.4% | 3 | WIN |
| WAS@GB | WAS +3.5 | 56.5% | 6 | LOSS |
| WAS@GB | JORDAN LOVE OVER 5.5 RUSH YDS | 54.7% | 4 | WIN |
| MIN@CHI | CALEB WILLIAMS OVER 219.5 PASS YDS | 53.4% | 3 | LOSS |
| TEN@DEN | DEN -8.5 | 55.3% | 5 | LOSS |
| SF@SEA | SF -115 | 54.6% | 4 | WIN |
| SF@SEA | KENNETH WALKER III UNDER 79.5 RUSH+REC YDS | 54.6% | 4 | WIN |
| CAR@JAC | TANK BIGSBY OVER 10.5 RUSH ATT | 56.1% | 6 | LOSS |
| KC@LAC | JUSTIN HERBERT UNDER 0.5 INT | 54.1% | 3 | WIN |
| DAL@PHI | GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS | 54.1% | 4 | LOSS |
| KC@PHI | JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS | 53.90% | 5 | WIN |
| KC@PHI | DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS | 54.40% | 6 | WIN |
| KC@PHI | PATRICK MAHOMES UNDER 68.3% PASS COMP | 55.00% | 8 | WIN |
| KC@PHI | JALEN HURTS LONGEST RUSH OVER 12.5 YDS | 55.60% | 8 | WIN |
| BUF@KC | DALTON KINCAID OVER 29.5 RECV YDS | 55.10% | 8 | LOSS |
| WAS@PHI | DEVONTA SMITH OVER 3.5 RECEPTIONS | 55.80% | 8 | WIN |
| BUF@KC | JAMES COOK ANYTIME TD | 53.00% | 5 | WIN |
| LAR@PHI | SAQUON BARKLEY UNDER 128 RUSH + REC YDS | 53.20% | 5 | LOSS |
| BAL@BUF | LAMAR JACKSON OVER 54.5 RUSH YDS | 54.50% | 6 | LOSS |
| HOU@KC | C.J. STROUD RUSH YDS UNDER 14.5 | 53.10% | 5 | LOSS |
| WAS@DET | JAMESON WILLIAMS RUSH YDS OVER 1.5 | 53.30% | 5 | WIN |
| WAS@DET | JARED GOFF PASS COMP % UNDER 72.3 | 54.30% | 6 | WIN |
| MIN@LAR | COOPER KUPP ANYTIME TOUCHDOWN | 52.60% | 3 | LOSS |
| MIN@LAR | MATTHEW STAFFORD OVER 21.5 PASS COMP | 54.10% | 6 | LOSS |
| WAS@TB | BRIAN ROBINSON JR OVER 1.5 REC TARGETS | 53.50% | 5 | WIN |
| WAS@TB | BAKER MAYFIELD UNDER 33.5 PASS ATT | 54.90% | 6 | WIN |
| GB@PHI | JALEN HURTS OVER 67.1 PASS COMP PERCENTAGE | 54.60% | 6 | LOSS |
| LAC@HOU | J.K. DOBBINS ANYTIME TD | 52.80% | 3 | LOSS |
| LAC@HOU | LAC -2.5 | 53.40% | 3 | LOSS |
| LAC@HOU | JUSTIN HERBERT OVER 19.5 RUSH YDS | 53.40% | 5 | LOSS |