Lions vs Colts Prediction — AI Finds CAN'T MISS NFL Lines & Props (Nov 24)

Updated: 2024-11-17T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On November 24, 2024, the Detroit Lions (9-1) will visit the Indianapolis Colts (5-6) at Lucas Oil Stadium. The Lions aim to extend their eight-game winning streak, while the Colts seek to build momentum after a recent victory.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Nov 24, 2024

Start Time: 2:00 PM EST​

Venue: Lucas Oil Stadium​

Colts Record: (5-5)

Lions Record: (9-1)

OPENING ODDS

DET Moneyline: -380

IND Moneyline: +301

DET Spread: -7.5

IND Spread: +7.5

Over/Under: 50.5

DET
Betting Trends

  • The Lions have been impressive against the spread (ATS) this season, covering in 7 of their last 8 games. Their consistent performance has made them a reliable choice for bettors.

IND
Betting Trends

  • The Colts have also performed well ATS, covering in 7 of their last 9 games. Their ability to exceed betting expectations has been notable, especially considering their overall record.

MATCHUP TRENDS

  • The Lions are favored by 7.5 points in this matchup. Historically, when favored by more than a touchdown on the road, Detroit has covered the spread in 4 of their last 5 games.

DET vs. IND
Best Prop Bet

  • Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.

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Detroit vs Indianapolis Prediction & Odds:
Free NFL Betting Insights for 11/24/24

The Detroit Lions, boasting a 9-1 record, are experiencing their best start since 1934, highlighted by an eight-game winning streak. Their recent 52-6 victory over the Jacksonville Jaguars showcased a potent offense and a stifling defense. Quarterback Jared Goff delivered a stellar performance, surpassing 400 passing yards with a perfect passer rating, setting multiple franchise records. The Lions’ balanced attack, featuring a strong running game and a deep receiving corps, has been difficult for opponents to contain. Defensively, they have been formidable, consistently limiting opponents’ scoring opportunities and creating turnovers. The Indianapolis Colts, with a 5-6 record, have faced a tumultuous season but are hopeful after an encouraging win against the New York Jets.

Quarterback Anthony Richardson returned to the starting lineup and delivered a strong performance, demonstrating maturity following a temporary benching. The Colts’ offense has shown flashes of potential, particularly in the running game, which could be a focal point in this matchup. Defensively, they have been inconsistent, struggling to contain high-powered offenses, which could be a concern against the Lions’ potent attack. Key factors in this game include the Lions’ ability to maintain their offensive efficiency against a Colts defense that has been vulnerable to big plays. The Colts will need to capitalize on any opportunities to exploit the Lions’ defense, particularly through their ground attack. Special teams could also play a crucial role, as field position and clutch kicking may determine the outcome in what is expected to be a closely contested game.

Detroit Lions NFL Preview

The Detroit Lions are enjoying a remarkable season, boasting a 9-1 record and an eight-game winning streak. Quarterback Jared Goff has been instrumental in this success, delivering consistent and efficient performances. His connection with the receiving corps, including standout performances from wide receivers Amon-Ra St. Brown and Jameson Williams, has been a cornerstone of the offense. The running game, featuring D’Andre Swift and Jamaal Williams, has provided balance, keeping defenses honest and opening up opportunities in the passing game. Defensively, the Lions have been formidable, with a front seven that excels in applying pressure and stopping the run. The secondary has been opportunistic, contributing to the team’s impressive turnover margin. Special teams have also been a strength, with reliable kicking and punting units, as well as explosive return capabilities that have provided advantageous field positions. The coaching staff has been praised for effective game planning and in-game adjustments, positioning the Lions as strong contenders in the NFC.

On November 24, 2024, the Detroit Lions (9-1) will visit the Indianapolis Colts (5-6) at Lucas Oil Stadium. The Lions aim to extend their eight-game winning streak, while the Colts seek to build momentum after a recent victory. Detroit vs Indianapolis AI Prediction: Free NFL Betting Insights for Nov 24. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Indianapolis Colts NFL Preview

The Indianapolis Colts have faced a challenging season, entering this game with a 5-6 record. Injuries and inconsistent play have plagued the team, leading to a series of disappointing performances. However, the recent reinstatement of quarterback Anthony Richardson has injected new life into the offense. Richardson’s dual-threat capability adds a dynamic element, allowing for a more versatile offensive scheme. The running game, led by Jonathan Taylor, has been a bright spot, providing stability and setting up play-action opportunities. Defensively, the Colts have struggled to contain high-powered offenses, particularly in the secondary, which has been susceptible to big plays. The pass rush has been inconsistent, failing to generate the pressure needed to disrupt opposing quarterbacks. Special teams have been reliable, with kicker Rodrigo Blankenship providing consistency in the kicking game. The coaching staff faces the challenge of addressing these issues and formulating a game plan to counter the Lions’ potent offense.

Detroit vs. Indianapolis Prop Picks (AI)

Remi is pouring through loads of data on each team. In fact, anytime the Lions and Colts play there’s always several intriguing trends to key in on. Not to mention games played at Lucas Oil Stadium in Nov almost always follow normal, predictable betting trends.
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.

Detroit vs. Indianapolis Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every angle between the Lions and Colts and using recursive machine learning and impressive AI to examine the data to a single cover probability.

Remi has been most fixated on the linear correlation of emphasis knucklehead sportsbettors tend to put on Detroit’s strength factors between a Lions team going up against a possibly healthy Colts team. In reality, the true game analytics appear to reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Detroit vs Indianapolis picks, computer picks Lions vs Colts, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NFL 10/20 HOU@SEA UNLOCK THIS PICK 5 INTEL Locked INTEL
NFL 10/20 TB@DET UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/20 TB@DET UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/20 TB@DET UNLOCK THIS PICK 1 INTEL Locked INTEL
NFL 10/20 HOU@SEA UNLOCK THIS PICK 0 INTEL Locked INTEL
NFL 10/20 TB@DET UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Lions Betting Trends

The Lions have been impressive against the spread (ATS) this season, covering in 7 of their last 8 games. Their consistent performance has made them a reliable choice for bettors.

Colts Betting Trends

The Colts have also performed well ATS, covering in 7 of their last 9 games. Their ability to exceed betting expectations has been notable, especially considering their overall record.

Lions vs. Colts Matchup Trends

The Lions are favored by 7.5 points in this matchup. Historically, when favored by more than a touchdown on the road, Detroit has covered the spread in 4 of their last 5 games.

Detroit vs. Indianapolis Game Info

Detroit vs Indianapolis starts on November 24, 2024 at 2:00 PM EST.

Spread: Indianapolis +7.5
Moneyline: Detroit -380, Indianapolis +301
Over/Under: 50.5

Detroit: (9-1)  |  Indianapolis: (5-5)

Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.

The Lions are favored by 7.5 points in this matchup. Historically, when favored by more than a touchdown on the road, Detroit has covered the spread in 4 of their last 5 games.

DET trend: The Lions have been impressive against the spread (ATS) this season, covering in 7 of their last 8 games. Their consistent performance has made them a reliable choice for bettors.

IND trend: The Colts have also performed well ATS, covering in 7 of their last 9 games. Their ability to exceed betting expectations has been notable, especially considering their overall record.

See our latest NFL picks and odds pages for 2024 to compare prices before you bet.

Detroit vs. Indianapolis Odds

Remi is pouring through tons of data points on each line. In fact, anytime the Detroit vs Indianapolis trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps almost always follow normal, predictable betting trends.

Detroit vs Indianapolis Opening Odds

DET Moneyline: -380
IND Moneyline: +301
DET Spread: -7.5
IND Spread: +7.5
Over/Under: 50.5

Detroit vs Indianapolis Live Odds

Games PTS ML SPR O/U
Oct 23, 2025 8:15PM EDT
Minnesota Vikings
Los Angeles Chargers
10/23/25 8:15PM
Vikings
Chargers
+142
-165
+3 (-110)
-3 (-110)
O 45 (-110)
U 45 (-110)
Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
+290
-360
+7 (-110)
-7 (-110)
O 40.5 (-110)
U 40.5 (-110)
Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
-400
+320
-7.5 (-110)
+7.5 (-110)
O 45.5 (-110)
U 45.5 (-110)
Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
+250
-300
+6.5 (-105)
-6.5 (-115)
O 44.5 (-105)
U 44.5 (-115)
Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
+265
-325
+7 (-120)
-7 (+100)
O 50 (-110)
U 50 (-110)
Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
+290
-360
+7 (-105)
-7 (-115)
O 43.5 (-115)
U 43.5 (-105)
Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
-110
-106
-1.5 (-104)
+1.5 (-118)
O 41.5 (-115)
U 41.5 (-105)
Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
+280
-350
+7 (-110)
-7 (-110)
O 44.5 (-110)
U 44.5 (-110)
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
-220
+184
-4.5 (-112)
+4.5 (-108)
O 47.5 (-105)
U 47.5 (-115)
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
+146
-170
+3 (+100)
-3 (-120)
O 49.5 (-110)
U 49.5 (-110)
Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
+750
-1200
+14 (-110)
-14 (-110)
O 47 (-110)
U 47 (-110)
Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
-185
+159
-3.5 (-105)
+3.5 (-115)
O 45 (-113)
U 45 (-107)
Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
+465
-630
+10.5 (-115)
-10.5 (-105)
O 48.5 (-110)
U 48.5 (-110)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Detroit Lions vs. Indianapolis Colts on November 24, 2024 at Lucas Oil Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS
HOU@BAL HOU -125 58.5% 7 WIN
DET@CIN DET -10 55.6% 5 WIN
DAL@NYJ NYJ +1.5 53.7% 3 LOSS
TB@SEA TB +3.5 54.9% 4 WIN
TEN@ARI ARI -7 (BUY 0.5) 54.9% 4 LOSS
DEN@PHI DEN +4.5 57.5% 7 WIN
MIA@CAR TETAIROA MCMILLAN OVER 58.5 RECV YDS 54.5% 4 WIN
LV@IND ASHTON JEANTY UNDER 67.5 RUSH YDS 54.4% 4 WIN
SF@LAR DEMARCUS ROBINSON OVER 29.5 RECV YDS 55.7% 5 WIN
NYJ@MIA NYJ +3 53.8 3 LOSS
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS
TEN@HOU TEN +7.5 57.9% 7 LOSS
LAC@NYG LAC -6 57.3% 7 LOSS
NO@BUF UNDER 48.5 55.1% 3 LOSS
GB@DAL JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS 55.5% 5 LOSS
CAR@NE DRAKE MAYE TO THROW AN INT 56.6% 6 LOSS
SEA@ARI SEA -125 57.7% 6 WIN
SEA@ARI KYLER MURRAY TO THROW AN INT 56.6% 6 WIN
DET@BAL JAHMYR GIBBS OVER 0.5 RUSH TDS 55.8% 5 WIN
DAL@CHI DAL -120 58.7% 6 LOSS
PIT@NE PIT -116 60.1% 6 WIN
ATL@CAR ATL -4.5 55.4% 5 LOSS
LV@WAS LV +3 54.3% 4 LOSS