Chiefs vs Bills Prediction — AI Finds CAN'T MISS NFL Lines & Props (Nov 17)
Updated: 2024-11-10T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
On November 17, 2024, the Kansas City Chiefs (9-0) will visit the Buffalo Bills (8-2) at Highmark Stadium in Orchard Park, New York. This highly anticipated matchup features two of the AFC’s top teams, both aiming to solidify their standings as the playoffs approach.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Nov 17, 2024
Start Time: 5:25 PM EST
Venue: Highmark Stadium
Bills Record: (8-2)
Chiefs Record: (9-0)
OPENING ODDS
KC Moneyline: +110
BUF Moneyline: -130
KC Spread: +2.5
BUF Spread: -2.5
Over/Under: 45.5
KC
Betting Trends
- The Chiefs have been impressive against the spread (ATS) this season, covering in 5 of their 7 games, reflecting a 71.4% success rate.
BUF
Betting Trends
- The Bills have also performed well ATS, covering in 5 of their 8 games, indicating a 62.5% success rate.
MATCHUP TRENDS
- Patrick Mahomes and the Chiefs are 12-1-1 ATS in the underdog role, including an 11-3 mark outright, showcasing their resilience when not favored.
KC vs. BUF
Best Prop Bet
- Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.
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Kansas City vs Buffalo Prediction & Odds:
Free NFL Betting Insights for 11/17/24
Defensively, Buffalo allows an average of 19 points per game. Linebacker Matt Milano anchors the defense with 80 tackles and 4 sacks, providing leadership and playmaking ability. The secondary, led by cornerback Tre’Davious White, has been formidable, contributing to the team’s 12 interceptions. The defense excels in pass coverage and creating turnovers, posing a challenge for opposing offenses. Special teams could play a pivotal role in this matchup. Chiefs kicker Harrison Butker has been reliable, converting 90% of his field goal attempts, while Bills kicker Tyler Bass has maintained an 88% conversion rate. Field position and the kicking game may influence the outcome in what is expected to be a closely contested battle. In summary, this game features two high-powered offenses and opportunistic defenses. The Chiefs will aim to exploit the Bills’ run defense, while Buffalo seeks to capitalize on Kansas City’s secondary. Turnovers and third-down efficiency are likely to be key factors in determining the winner of this contest.
You won’t see him coming 🤫@lchenal54 x @PatrickMahomes pic.twitter.com/AG1cJEfmHx
— Kansas City Chiefs (@Chiefs) November 11, 2024
Kansas City Chiefs NFL Preview
The Buffalo Bills have had a successful season, with an 8-2 record, showcasing one of the league’s most balanced teams. Quarterback Josh Allen continues to lead a potent offense, throwing for over 2,800 yards and 24 touchdowns while adding 400 rushing yards and 5 rushing touchdowns. Wide receiver Stefon Diggs has been his go-to target, with 900 receiving yards and 9 touchdowns, while tight end Dalton Kincaid has emerged as a reliable option in the red zone. Running back James Cook has been a valuable asset, rushing for 600 yards and 5 touchdowns, providing balance and allowing Buffalo to vary its offensive strategies. On defense, the Bills allow an average of 19 points per game, emphasizing a disciplined and effective approach. Linebacker Matt Milano has been instrumental, recording 80 tackles and 4 sacks, while Tre’Davious White has anchored the secondary with strong coverage skills and interceptions. The defensive front has been effective in generating pressure, with defensive end Greg Rousseau recording 6 sacks. The Bills’ defense has excelled in creating turnovers, with a season total of 12 interceptions, making it difficult for opposing offenses to sustain drives. Special teams play has been solid for Buffalo as well. Kicker Tyler Bass has been reliable, converting 88% of his field goal attempts, and punter Sam Martin has helped control field position with an average punt distance of 47 yards. The return game, led by Khalil Shakir, has provided steady field position for Allen and the offense. Head coach Sean McDermott has built a cohesive unit that excels on both sides of the ball. Offensive coordinator Ken Dorsey has maximized Allen’s abilities while creating opportunities for the receiving corps. Defensive coordinator Leslie Frazier has emphasized discipline and aggression, leading to high turnover rates and effective pass coverage. For the Bills, maintaining their efficient offense and disruptive defense will be essential as they look to challenge Kansas City’s high-powered attack. In the upcoming games, Buffalo will look to solidify their playoff position by building on their defensive discipline and capitalizing on Allen’s dual-threat abilities. The Bills’ emphasis on balanced offense and turnover creation will be crucial in their quest to advance deep into the postseason.
Credit: USA TODAY/IMAGN
Buffalo Bills NFL Preview
The Kansas City Chiefs have experienced a stellar season, currently holding a 9-0 record. Offensively, quarterback Patrick Mahomes has been instrumental, throwing for over 3,000 yards and 25 touchdowns. His rapport with tight end Travis Kelce remains strong, with Kelce amassing 800 receiving yards and 8 touchdowns. The addition of wide receiver DeAndre Hopkins has provided an additional target, contributing 600 receiving yards and 5 touchdowns. The running game, led by Isiah Pacheco, has added balance, with Pacheco rushing for 700 yards and 6 touchdowns. The offensive line has performed well, allowing only 15 sacks, which has kept Mahomes upright and the offense in rhythm. Defensively, the Chiefs have been anchored by linebacker Nick Bolton, who has recorded 85 tackles and consistently disrupted opposing offenses. Defensive end George Karlaftis leads the team with 8 sacks, showcasing his ability to pressure quarterbacks. The secondary, featuring cornerback L’Jarius Sneed, has been effective, with the team recording 10 interceptions. The defense has shown improvement against the run, allowing 110 rushing yards per game, indicating a more balanced defensive unit. Special teams have been a consistent asset for the Chiefs. Kicker Harrison Butker has been reliable, converting 90% of his field goal attempts, including several from beyond 50 yards. Punter Tommy Townsend has been effective in flipping field position, averaging 48 yards per punt. The return game, led by rookie wide receiver Rashee Rice, has provided solid field position, contributing to the offense’s success. The coaching staff, under head coach Andy Reid, has emphasized a balanced offensive attack and aggressive defensive schemes. Offensive coordinator Eric Bieniemy has implemented creative play designs that maximize the talents of Mahomes and the receiving corps. Defensive coordinator Steve Spagnuolo has focused on leveraging the strengths of key players like Bolton and Karlaftis to create pressure and force turnovers. Looking ahead, the Chiefs aim to maintain their undefeated streak and secure the top seed in the AFC. Maintaining offensive balance and continuing defensive improvement will be crucial as they face formidable opponents in the latter part of the season.
BILLS WIN!!!!#BUFvsIND | #BillsMafia pic.twitter.com/rOm5yIWqDy
— Buffalo Bills (@BuffaloBills) November 10, 2024
Kansas City vs. Buffalo Prop Picks (AI)
Kansas City vs. Buffalo Prediction (AI)
Remi, our AI sports wizard, has been pouring over mountains of data from every simulation between the Chiefs and Bills and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most keyed in on the growing factor emotional bettors regularly put on coaching factors between a Chiefs team going up against a possibly improved Bills team. Trends look to say the true game analytics appear to reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Kansas City vs Buffalo picks, computer picks Chiefs vs Bills, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 5 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 1 |
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| NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 0 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Chiefs Betting Trends
The Chiefs have been impressive against the spread (ATS) this season, covering in 5 of their 7 games, reflecting a 71.4% success rate.
Bills Betting Trends
The Bills have also performed well ATS, covering in 5 of their 8 games, indicating a 62.5% success rate.
Chiefs vs. Bills Matchup Trends
Patrick Mahomes and the Chiefs are 12-1-1 ATS in the underdog role, including an 11-3 mark outright, showcasing their resilience when not favored.
Kansas City vs. Buffalo Game Info
What time does Kansas City vs Buffalo start on November 17, 2024?
Kansas City vs Buffalo starts on November 17, 2024 at 5:25 PM EST.
Where is Kansas City vs Buffalo being played?
Venue: Highmark Stadium.
What are the opening odds for Kansas City vs Buffalo?
Spread: Buffalo -2.5
Moneyline: Kansas City +110, Buffalo -130
Over/Under: 45.5
What are the records for Kansas City vs Buffalo?
Kansas City: (9-0) | Buffalo: (8-2)
What is the AI best bet for Kansas City vs Buffalo?
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.
What are Kansas City vs Buffalo trending bets?
Patrick Mahomes and the Chiefs are 12-1-1 ATS in the underdog role, including an 11-3 mark outright, showcasing their resilience when not favored.
What are Kansas City trending bets?
KC trend: The Chiefs have been impressive against the spread (ATS) this season, covering in 5 of their 7 games, reflecting a 71.4% success rate.
What are Buffalo trending bets?
BUF trend: The Bills have also performed well ATS, covering in 5 of their 8 games, indicating a 62.5% success rate.
Where can I find AI Picks for Kansas City vs Buffalo?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
Kansas City vs. Buffalo Odds
AI algorithm Remi is pouring through loads of data on each player. In fact, anytime the Kansas City vs Buffalo trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable betting trends.
Kansas City vs Buffalo Opening Odds
KC Moneyline:
+110 BUF Moneyline: -130
KC Spread: +2.5
BUF Spread: -2.5
Over/Under: 45.5
Kansas City vs Buffalo Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Oct 23, 2025 8:15PM EDT
Minnesota Vikings
Los Angeles Chargers
10/23/25 8:15PM
Vikings
Chargers
|
–
–
|
+146
-174
|
+3 (-102)
-3 (-120)
|
O 44.5 (-112)
U 44.5 (-108)
|
|
|
Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
|
–
–
|
+290
-360
|
+7 (-114)
-7 (-106)
|
O 40.5 (-105)
U 40.5 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
|
–
–
|
-370
+295
|
-7.5 (-102)
+7.5 (-120)
|
O 46.5 (-105)
U 46.5 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
|
–
–
|
+245
-300
|
+6.5 (-110)
-6.5 (-110)
|
O 43.5 (-115)
U 43.5 (-105)
|
|
|
Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
|
–
–
|
+265
-330
|
+6.5 (-106)
-6.5 (-114)
|
O 50.5 (-105)
U 50.5 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
|
–
–
|
+285
-355
|
+7 (-108)
-7 (-112)
|
O 43.5 (-105)
U 43.5 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
|
–
–
|
-102
-118
|
+1.5 (-115)
-1.5 (-105)
|
O 41.5 (-110)
U 41.5 (-110)
|
|
|
Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
|
–
–
|
+280
-350
|
+7.5 (-122)
-7.5 (+100)
|
O 44.5 (-114)
U 44.5 (-106)
|
|
|
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
|
–
–
|
-225
+188
|
-4.5 (-106)
+4.5 (-114)
|
O 46.5 (-114)
U 46.5 (-106)
|
|
|
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
|
–
–
|
+146
-174
|
+3.5 (-118)
-3.5 (-104)
|
O 49.5 (-120)
U 49.5 (-102)
|
|
|
Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
|
–
–
|
+750
-1200
|
+14.5 (-118)
-14.5 (-104)
|
O 46.5 (-114)
U 46.5 (-106)
|
|
|
Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
|
–
–
|
-176
+148
|
-3.5 (-104)
+3.5 (-118)
|
O 44.5 (-115)
U 44.5 (-105)
|
|
|
Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
|
–
–
|
+430
-590
|
+10.5 (-110)
-10.5 (-110)
|
O 47.5 (-110)
U 47.5 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Kansas City Chiefs vs. Buffalo Bills on November 17, 2024 at Highmark Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
| CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
| PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
| GB@ARI | ARI +7 | 54.8% | 5 | WIN |
| NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
| WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
| GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
| PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
| BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
| CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
| TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
| DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
| SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
| LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
| ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
| TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
| LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
| SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
| CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
| DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
| KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
| KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
| HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
| DET@CIN | DET -10 | 55.6% | 5 | WIN |
| DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
| TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
| TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
| DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
| MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
| LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
| SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
| NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
| CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
| NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
| CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
| NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
| CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
| WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
| BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
| TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
| LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
| NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
| GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
| CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |