49ers vs Buccaneers Prediction — AI Finds CAN'T MISS NFL Lines & Props (Nov 10)

Updated: 2024-11-03T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The San Francisco 49ers (4-4) will face the Tampa Bay Buccaneers (4-4) on November 10, 2024, at Raymond James Stadium in Tampa, Florida. Both teams are seeking to improve their records and strengthen their positions in their respective divisions.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Nov 10, 2024

Start Time: 2:00 PM EST​

Venue: Raymond James Stadium​

Buccaneers Record: (4-5)

49ers Record: (4-4)

OPENING ODDS

SF Moneyline: -278

TB Moneyline: +227

SF Spread: -6.5

TB Spread: +6.5

Over/Under: 48.5

SF
Betting Trends

  • The 49ers have covered the spread in 5 of their last 8 games this season, indicating a 62.5% success rate against the spread (ATS).

TB
Betting Trends

  • The Buccaneers have covered the spread in 3 of their last 8 games this season, reflecting a 37.5% ATS success rate.

MATCHUP TRENDS

  • In their last five head-to-head matchups, the 49ers have covered the spread four times against the Buccaneers, suggesting a favorable trend for San Francisco in this series.

SF vs. TB
Best Prop Bet

  • Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.

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San Francisco vs Tampa Bay Prediction & Odds:
Free NFL Betting Insights for 11/10/24

The San Francisco 49ers and Tampa Bay Buccaneers, both holding 4-4 records, are set to clash in a pivotal Week 10 matchup. The 49ers are coming off a bye week, providing them with additional time to recover and strategize. Quarterback Brock Purdy has shown promise, amassing over 2,100 passing yards and 10 touchdowns this season. The potential return of running back Christian McCaffrey, who has been sidelined with an Achilles injury, could significantly bolster the 49ers’ offensive dynamics. Defensively, San Francisco has been formidable, with linebacker Fred Warner leading the charge and earning midseason All-Pro honors.

Conversely, the Buccaneers are grappling with a two-game losing streak and have been plagued by injuries, notably to key receivers Mike Evans and Chris Godwin. Quarterback Baker Mayfield has been inconsistent, and the team’s defense has allowed over 30 points per game in recent outings. The Buccaneers’ struggles in both offensive production and defensive resilience have contributed to their current challenges. This game is crucial for both teams as they vie for playoff contention. The 49ers’ balanced attack and defensive prowess position them as favorites, while the Buccaneers must address their vulnerabilities to secure a home victory.

San Francisco 49ers NFL Preview

The San Francisco 49ers, holding a 4-4 record, are looking to build momentum in the second half of the season. Quarterback Brock Purdy has been effective, completing 156 of 242 passes for 2,101 yards, 10 touchdowns, and 7 interceptions. Tight end George Kittle has been a reliable target, recording 40 receptions for 503 yards and 6 touchdowns. The potential return of running back Christian McCaffrey, who has been on injured reserve, could provide a significant boost to the running game. Defensively, the 49ers have been strong, with linebacker Fred Warner leading the team with multiple interceptions and forced fumbles. The secondary has been solid, with cornerback Deommodore Lenoir excelling in coverage. The defensive line, however, has faced challenges in consistently pressuring opposing quarterbacks. Special teams have been reliable, with kicker Jake Moody converting key field goals and the return units providing favorable field positions. Head coach Kyle Shanahan emphasizes discipline and execution as the team prepares for the Buccaneers. The 49ers aim to capitalize on the Buccaneers’ recent struggles and leverage their balanced attack to secure a road victory.

The San Francisco 49ers (4-4) will face the Tampa Bay Buccaneers (4-4) on November 10, 2024, at Raymond James Stadium in Tampa, Florida. Both teams are seeking to improve their records and strengthen their positions in their respective divisions. San Francisco vs Tampa Bay AI Prediction: Free NFL Betting Insights for Nov 10. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Tampa Bay Buccaneers NFL Preview

The Tampa Bay Buccaneers enter Week 10 with a 4-4 record, facing challenges on both sides of the ball. Offensively, quarterback Baker Mayfield has thrown for over 2,100 yards and 21 touchdowns but has also committed 9 interceptions, reflecting inconsistency. The absence of top receivers Mike Evans and Chris Godwin due to injuries has further hampered the passing game. Running back Brian Irving has been a bright spot, rushing for 395 yards and 3 touchdowns, but the overall offensive output has been insufficient. Defensively, the Buccaneers have struggled, allowing an average of over 30 points per game in their last five contests. The secondary has been particularly vulnerable, giving up significant yardage through the air. Linebacker Lavonte David continues to be a leader on defense, but the unit as a whole has been unable to contain opposing offenses effectively. Special teams have been inconsistent, with missed field goals and subpar return coverage contributing to unfavorable field positions. Head coach Todd Bowles faces the challenge of addressing these issues to prevent the season from slipping further. Hosting the 49ers, the Buccaneers must improve their defensive performance and find ways to compensate for the injuries on offense to secure a win.

San Francisco vs. Tampa Bay Prop Picks (AI)

AI algorithm Remi is pouring through mountains of data on each team. In fact, anytime the 49ers and Buccaneers play there’s always several intriguing angles to key in on. Not to mention games played at Raymond James Stadium in Nov can often follow normal, predictable patterns.
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.

San Francisco vs. Tampa Bay Prediction (AI)

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Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every simulation between the 49ers and Buccaneers and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.

The Algorithm has been most keyed in on the growing factor emotional bettors often put on San Francisco’s strength factors between a 49ers team going up against a possibly deflated Buccaneers team. In reality, the true game analytics might reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI San Francisco vs Tampa Bay picks, computer picks 49ers vs Buccaneers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NFL 11/10 PHI@GB UNLOCK THIS PICK 6 VAULT v3 Locked VAULT v3
NFL 11/10 PHI@GB UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 11/10 PHI@GB UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 11/10 PHI@GB UNLOCK THIS PICK 1 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

49ers Betting Trends

The 49ers have covered the spread in 5 of their last 8 games this season, indicating a 62.5% success rate against the spread (ATS).

Buccaneers Betting Trends

The Buccaneers have covered the spread in 3 of their last 8 games this season, reflecting a 37.5% ATS success rate.

49ers vs. Buccaneers Matchup Trends

In their last five head-to-head matchups, the 49ers have covered the spread four times against the Buccaneers, suggesting a favorable trend for San Francisco in this series.

San Francisco vs. Tampa Bay Game Info

San Francisco vs Tampa Bay starts on November 10, 2024 at 2:00 PM EST.

Spread: Tampa Bay +6.5
Moneyline: San Francisco -278, Tampa Bay +227
Over/Under: 48.5

San Francisco: (4-4)  |  Tampa Bay: (4-5)

Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.

In their last five head-to-head matchups, the 49ers have covered the spread four times against the Buccaneers, suggesting a favorable trend for San Francisco in this series.

SF trend: The 49ers have covered the spread in 5 of their last 8 games this season, indicating a 62.5% success rate against the spread (ATS).

TB trend: The Buccaneers have covered the spread in 3 of their last 8 games this season, reflecting a 37.5% ATS success rate.

See our latest NFL picks and odds pages for 2024 to compare prices before you bet.

San Francisco vs. Tampa Bay Odds

AI algorithm Remi is pouring through loads of data on each team. In fact, anytime the San Francisco vs Tampa Bay trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable patterns.

San Francisco vs Tampa Bay Opening Odds

SF Moneyline: -278
TB Moneyline: +227
SF Spread: -6.5
TB Spread: +6.5
Over/Under: 48.5

San Francisco vs Tampa Bay Live Odds

Games PTS ML SPR O/U
Nov 10, 2025 8:15PM EST
Philadelphia Eagles
Green Bay Packers
11/10/25 8:15PM
Eagles
Packers
-105
-115
-1 (-110)
+1 (-110)
O 45 (-110)
U 45 (-110)
Nov 13, 2025 8:15PM EST
New York Jets
New England Patriots
11/13/25 8:15PM
Jets
Patriots
+550
-850
+12 (-110)
-12 (-110)
O 43 (-115)
U 43 (-105)
Nov 16, 2025 9:30AM EST
Washington Commanders
Miami Dolphins
11/16/25 9:30AM
Commanders
Dolphins
+130
-150
+2.5 (+100)
-2.5 (-120)
O 47.5 (-110)
U 47.5 (-110)
Nov 16, 2025 1:00PM EST
Carolina Panthers
Atlanta Falcons
11/16/25 1PM
Panthers
Falcons
+165
-195
+3.5 (-115)
-3.5 (-105)
O 42.5 (-110)
U 42.5 (-110)
Nov 16, 2025 1:00PM EST
Chicago Bears
Minnesota Vikings
11/16/25 1PM
Bears
Vikings
+140
-165
+3 (-110)
-3 (-110)
O 48 (-110)
U 48 (-110)
Nov 16, 2025 1:00PM EST
Los Angeles Chargers
Jacksonville Jaguars
11/16/25 1PM
Chargers
Jaguars
-150
+130
-3 (+100)
+3 (-120)
O 44 (-110)
U 44 (-110)
Nov 16, 2025 1:00PM EST
Green Bay Packers
New York Giants
11/16/25 1PM
Packers
Giants
-460
+360
-7.5 (-120)
+7.5 (-102)
O 44.5 (-110)
U 44.5 (-110)
Nov 16, 2025 1:00PM EST
Cincinnati Bengals
Pittsburgh Steelers
11/16/25 1PM
Bengals
Steelers
+205
-245
+5.5 (-110)
-5.5 (-110)
O 49.5 (-110)
U 49.5 (-110)
Nov 16, 2025 1:00PM EST
Tampa Bay Buccaneers
Buffalo Bills
11/16/25 1PM
Buccaneers
Bills
+225
-275
+5.5 (-110)
-5.5 (-110)
O 49.5 (-110)
U 49.5 (-110)
Nov 16, 2025 1:00PM EST
Houston Texans
Tennessee Titans
11/16/25 1PM
Texans
Titans
-370
+285
-7 (-110)
+7 (-110)
O 39.5 (-105)
U 39.5 (-115)
Nov 16, 2025 4:05PM EST
San Francisco 49ers
Arizona Cardinals
11/16/25 4:05PM
49ers
Cardinals
-150
+130
-2.5 (-120)
+2.5 (+100)
O 49 (-115)
U 49 (-105)
Nov 16, 2025 4:05PM EST
Seattle Seahawks
Los Angeles Rams
11/16/25 4:05PM
Seahawks
Rams
+130
-150
+2.5 (+100)
-2.5 (-120)
O 48 (-115)
U 48 (-105)
Nov 16, 2025 4:25PM EST
Kansas City Chiefs
Denver Broncos
11/16/25 4:25PM
Chiefs
Broncos
-210
+175
-4 (-110)
+4 (-110)
O 44.5 (-115)
U 44.5 (-105)
Nov 16, 2025 4:25PM EST
Baltimore Ravens
Cleveland Browns
11/16/25 4:25PM
Ravens
Browns
-470
+345
-8 (-110)
+8 (-110)
O 41.5 (-115)
U 41.5 (-105)
Nov 16, 2025 8:20PM EST
Detroit Lions
Philadelphia Eagles
11/16/25 8:20PM
Lions
Eagles
+104
-122
+1.5 (-112)
-1.5 (-108)
O 48.5 (-110)
U 48.5 (-110)
Nov 17, 2025 8:15PM EST
Dallas Cowboys
Las Vegas Raiders
11/17/25 8:15PM
Cowboys
Raiders
-185
+160
-3.5 (+100)
+3.5 (-120)
O 50 (-110)
U 50 (-110)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Francisco 49ers vs. Tampa Bay Buccaneers on November 10, 2024 at Raymond James Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
LV@DEN RILEY MOSS OVER 4.5 TACKLE + ASST 54.8% 4 WIN
LV@DEN UNDER 43 53.4% 2 WIN
ARI@DAL BUDDA BAKER OVER 7.5 TACKLES + ASSTS 54.4% 4 WIN
ARI@DAL GEORGE PICKENS OVER 4.5 RECEPTIONS 56.6% 6 WIN
DEN@HOU WIL LUTZ OVER 1.5 MADE FIELD GOALS 54.2% 3 LOSS
SEA@WAS SEA -3 56.7% 6 WIN
IND@PIT IND -3 56.8% 6 LOSS
LAC@TEN LAC -9.5 56.2% 6 LOSS
CHI@CIN CHI -2.5 52.6% 2 WIN
SEA@WAS OVER 48 52.9% 2 WIN
SEA@WAS JAYDEN DANIELS OVER 20.5 PASS COMP 56.7% 6 LOSS
JAC@LV JAC -140 64.2% 7 WIN
NO@LAR LAR -14 55.0% 4 WIN
DEN@HOU HOU -1.5 54.2% 3 LOSS
CAR@GB GB -12.5 55.4% 5 LOSS
SF@NYG NYG +2.5 56.1% 5 LOSS
BAL@MIA TUA TAGOVAILOA UNDER 0.5 INT 55.3% 5 LOSS
TB@NO TB -3.5 52.3% 1 WIN
GB@PIT GB -2.5 52.3% 1 WIN
SF@HOU SF +2.5 56.0% 6 LOSS
NYG@PHI NYG +7.5 53.9% 3 LOSS
BUF@CAR CAR +7.5 54.2% 3 LOSS
DAL@DEN DAL +3.5 55.0% 4 LOSS
MIA@ATL MIA +7 54.3% 4 WIN
CLE@NE CLE +7 56.8% 6 LOSS
TB@NO BAKER MAYFIELD OVER 15.5 RUSH YDS 56.6% 6 LOSS
MIN@LAC JUSTIN HERBERT PASS ATT UNDER 35.5 55.5% 5 WIN
TB@DET TB +6.5 54.4% 4 LOSS
TB@DET RACHAAD WHITE UNDER 14.5 RUSH ATT 54.4% 4 WIN
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS