Bills vs. Colts
Prediction, Odds & Props
Nov 10 | NFL AI Picks
Updated: 2024-11-03T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Buffalo Bills (7-2) will visit the Indianapolis Colts (4-5) on November 10, 2024, at Lucas Oil Stadium. Both teams aim to bolster their playoff prospects in this crucial AFC matchup.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Nov 10, 2024
Start Time: 2:00 PM EST​
Venue: Lucas Oil Stadium​
Colts Record: (4-5)
Bills Record: (7-2)
OPENING ODDS
BUF Moneyline: -212
IND Moneyline: +177
BUF Spread: -4
IND Spread: +4.0
Over/Under: 47
BUF
Betting Trends
- The Bills have covered the spread in 5 of their last 7 games, showcasing consistent performance against expectations.
IND
Betting Trends
- The Colts have struggled at home, covering the spread in only 2 of their last 6 games at Lucas Oil Stadium.
MATCHUP TRENDS
- In their last five head-to-head meetings, the underdog has covered the spread four times, indicating closely contested games between these teams.
BUF vs. IND
Best Prop Bet
- Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.
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Buffalo vs Indianapolis Prediction & Odds:
Free NFL Betting Insights for 11/10/24
Defensively, the Colts have shown resilience, with notable performances from players like Grover Stewart, who recorded a strip-sack touchdown against the Vikings. However, containing dynamic offenses has been a challenge, as evidenced by their inability to limit the Vikings’ second-half surge. The Bills’ defense, on the other hand, has been formidable, effectively containing both the run and pass. Their ability to generate turnovers and apply pressure on opposing quarterbacks has been a cornerstone of their success. Special teams could also play a crucial role in this matchup. The Bills’ kicker, Tyler Bass, has demonstrated reliability and range, while the Colts’ special teams unit has had its share of inconsistencies. Coaching strategies will be under scrutiny, with the Bills’ staff likely focusing on exploiting the Colts’ defensive vulnerabilities and maintaining offensive momentum. The Colts’ coaching staff will need to devise a game plan that maximizes their offensive strengths while mitigating the Bills’ defensive pressure. Given the Bills’ current form and the Colts’ recent struggles, Buffalo enters this game as the favorite. However, the Colts’ home-field advantage and potential for offensive resurgence make them a team that cannot be underestimated. This game is expected to be a closely contested battle, with both teams looking to make a statement as the season progresses.
WHAT A WIN!!!!!!!#MIAvsBUF | #BillsMafia pic.twitter.com/viYo8jVTmV
— Buffalo Bills (@BuffaloBills) November 3, 2024
Buffalo Bills NFL Preview
The Buffalo Bills enter this matchup with a 7-2 record, riding a four-game winning streak that has solidified their position as one of the top teams in the AFC. Quarterback Josh Allen continues to be the catalyst for the offense, combining his arm strength and mobility to create explosive plays. In their recent victory over the Miami Dolphins, Allen orchestrated a game-winning drive that culminated in a record-breaking 61-yard field goal by Tyler Bass. The Bills’ receiving corps, featuring Stefon Diggs and Gabriel Davis, has been instrumental in stretching defenses and creating mismatches. The running game, led by James Cook, has provided balance, keeping opposing defenses honest. Defensively, the Bills have been formidable, ranking among the top in points allowed and defensive efficiency. Their ability to generate turnovers and apply pressure on opposing quarterbacks has been a cornerstone of their success. Linebacker Matt Milano and safety Jordan Poyer have been key contributors, providing leadership and playmaking ability. Special teams have also been a strength for the Bills, with kicker Tyler Bass demonstrating reliability and range and consistently converting crucial field goals, including his recent 61-yard game-winner against Miami. Bass’s accuracy and range add an extra layer of confidence for Buffalo’s offense, especially in close-game situations. Punter Sam Martin has also contributed positively to the field position battle, helping keep opposing teams in challenging starting positions. As they prepare to face the Colts, the Bills will focus on exploiting Indianapolis’s defensive vulnerabilities, particularly in pass coverage, where Josh Allen and his strong receiving corps can take advantage of potential mismatches. Establishing an effective ground game with James Cook will be essential to keep the Colts’ defense from focusing solely on Allen and the passing attack. Defensively, the Bills will aim to pressure Joe Flacco and disrupt the Colts’ offensive rhythm, especially by limiting Jonathan Taylor’s production in the running game. The Bills’ front seven, led by standout players like Matt Milano, will focus on closing running lanes and containing Taylor to force the Colts into more predictable passing situations. The coaching staff, led by Sean McDermott, will emphasize disciplined play and capitalizing on scoring opportunities early to establish momentum. The Bills enter this game with high confidence, aiming to extend their winning streak and maintain their position as a top contender in the AFC. By executing their game plan and leveraging their offensive firepower and defensive discipline, Buffalo hopes to secure a valuable road win and continue their march toward the postseason.

Credit: USA TODAY/IMAGN
Indianapolis Colts NFL Preview
The Indianapolis Colts have experienced a tumultuous season, marked by a 4-5 record and ongoing challenges at the quarterback position. Rookie Anthony Richardson’s developmental needs have paved the way for veteran Joe Flacco to assume the starting role. Despite Flacco’s extensive experience, the offense has struggled to find consistency, as highlighted by their inability to score an offensive touchdown in the recent 21-13 loss to the Minnesota Vikings. Running back Jonathan Taylor remains a focal point of the Colts’ offensive strategy. However, without a balanced attack, defenses have been able to concentrate on containing Taylor, limiting his effectiveness. The receiving corps, led by Michael Pittman Jr., has shown potential, but inconsistent quarterback play has hindered their productivity. Defensively, the Colts have exhibited resilience, with standout performances from players like Grover Stewart, who recorded a strip-sack touchdown against the Vikings. Linebacker Zaire Franklin and safety Nick Cross have also contributed with key interceptions. Despite these individual efforts, the defense has faced challenges in containing dynamic offenses, particularly in the second half of games. Special teams have been a mixed bag for the Colts. While kicker Matt Gay has been reliable, the coverage units have allowed significant returns, putting additional pressure on the defense. As they prepare to host the Buffalo Bills, the Colts will need to address their offensive inconsistencies and develop a game plan that leverages their strengths. Establishing a balanced attack that incorporates both the run and pass will be crucial. Defensively, the focus will be on containing Josh Allen and the Bills’ high-powered offense, requiring disciplined play and effective communication. The coaching staff, led by head coach Shane Steichen, will be tasked with instilling confidence and executing a strategy that maximizes the team’s potential. With the support of the home crowd at Lucas Oil Stadium, the Colts have an opportunity to make a statement and turn their season around.
Our Week 11 game against the Jets will now take place at 1pm ET on CBS. pic.twitter.com/QvSmZmnUug
— Indianapolis Colts (@Colts) November 4, 2024
Buffalo vs. Indianapolis Prop Picks (AI)
Buffalo vs. Indianapolis Prediction (AI)

Remi, our AI sports algorithm, has been pouring over tons of data from every angle between the Bills and Colts and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.
Interestingly enough, the data has been most fixated on the trending emphasis human bettors regularly put on coaching factors between a Bills team going up against a possibly improved Colts team. It appears the true game analytics appear to reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Buffalo vs Indianapolis picks, computer picks Bills vs Colts, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Bills Betting Trends
The Bills have covered the spread in 5 of their last 7 games, showcasing consistent performance against expectations.
Colts Betting Trends
The Colts have struggled at home, covering the spread in only 2 of their last 6 games at Lucas Oil Stadium.
Bills vs. Colts Matchup Trends
In their last five head-to-head meetings, the underdog has covered the spread four times, indicating closely contested games between these teams.
Buffalo vs. Indianapolis Game Info
What time does Buffalo vs Indianapolis start on November 10, 2024?
Buffalo vs Indianapolis starts on November 10, 2024 at 2:00 PM EST.
Where is Buffalo vs Indianapolis being played?
Venue: Lucas Oil Stadium.
What are the opening odds for Buffalo vs Indianapolis?
Spread: Indianapolis +4.0
Moneyline: Buffalo -212, Indianapolis +177
Over/Under: 47
What are the records for Buffalo vs Indianapolis?
Buffalo: (7-2) Â |Â Indianapolis: (4-5)
What is the AI best bet for Buffalo vs Indianapolis?
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.
What are Buffalo vs Indianapolis trending bets?
In their last five head-to-head meetings, the underdog has covered the spread four times, indicating closely contested games between these teams.
What are Buffalo trending bets?
BUF trend: The Bills have covered the spread in 5 of their last 7 games, showcasing consistent performance against expectations.
What are Indianapolis trending bets?
IND trend: The Colts have struggled at home, covering the spread in only 2 of their last 6 games at Lucas Oil Stadium.
Where can I find AI Picks for Buffalo vs Indianapolis?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
Buffalo vs. Indianapolis Odds
AI algorithm Remi is pouring through loads of stats on each line. In fact, anytime the Buffalo vs Indianapolis trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable betting trends.
Buffalo vs Indianapolis Opening Odds
BUF Moneyline:
-212 IND Moneyline: +177
BUF Spread: -4
IND Spread: +4.0
Over/Under: 47
Buffalo vs Indianapolis Live Odds
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Vikings
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–
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-140
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O 41 (-110)
U 41 (-110)
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-285
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O 44 (-110)
U 44 (-110)
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–
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+300
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+7 (-105)
-7 (-115)
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O 39 (-110)
U 39 (-110)
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Sep 28, 2025 1:01PM EDT
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Eagles
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–
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-190
+160
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-3.5 (-105)
+3.5 (-115)
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O 44 (-110)
U 44 (-110)
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–
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+105
-125
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+2.5 (-110)
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O 43.5 (-110)
U 43.5 (-110)
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Sep 28, 2025 1:01PM EDT
New Orleans Saints
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9/28/25 1:01PM
Saints
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–
–
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+800
-1300
|
+15 (-110)
-15 (-110)
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O 48 (-110)
U 48 (-110)
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Sep 28, 2025 1:01PM EDT
Carolina Panthers
New England Patriots
9/28/25 1:01PM
Panthers
Patriots
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–
–
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+200
-250
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+5.5 (-110)
-5.5 (-110)
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O 43.5 (-105)
U 43.5 (-115)
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Sep 28, 2025 4:06PM EDT
Jacksonville Jaguars
San Francisco 49ers
9/28/25 4:06PM
Jaguars
49ers
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–
–
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+150
-180
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+3.5 (-115)
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O 46.5 (-110)
U 46.5 (-110)
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Sep 28, 2025 4:06PM EDT
Indianapolis Colts
Los Angeles Rams
9/28/25 4:06PM
Colts
Rams
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–
–
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+160
-190
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+3.5 (-110)
-3.5 (-110)
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O 49.5 (-110)
U 49.5 (-110)
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Sep 28, 2025 4:25PM EDT
Baltimore Ravens
Kansas City Chiefs
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Ravens
Chiefs
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–
–
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-150
+125
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-2.5 (-120)
+2.5 (+100)
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O 48.5 (-110)
U 48.5 (-110)
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Sep 28, 2025 4:26PM EDT
Chicago Bears
Las Vegas Raiders
9/28/25 4:26PM
Bears
Raiders
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–
–
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+100
-120
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+1 (-110)
-1 (-110)
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O 48 (-110)
U 48 (-110)
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Sep 28, 2025 8:21PM EDT
Green Bay Packers
Dallas Cowboys
9/28/25 8:21PM
Packers
Cowboys
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–
–
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-325
+250
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-7 (-105)
+7 (-115)
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O 47 (-110)
U 47 (-110)
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Sep 29, 2025 7:15PM EDT
New York Jets
Miami Dolphins
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Jets
Dolphins
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–
–
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+125
-150
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+3 (-115)
-3 (-105)
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O 44.5 (-115)
U 44.5 (-105)
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Sep 29, 2025 8:15PM EDT
Cincinnati Bengals
Denver Broncos
9/29/25 8:15PM
Bengals
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–
–
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+310
-400
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+7.5 (-110)
-7.5 (-110)
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O 44 (-110)
U 44 (-110)
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Oct 2, 2025 8:16PM EDT
San Francisco 49ers
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–
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+134
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+3 (-110)
-3 (-110)
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O 47.5 (-105)
U 47.5 (-115)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Buffalo Bills vs. Indianapolis Colts on November 10, 2024 at Lucas Oil Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
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   LEAN |    %WIN |    UNITS | RESULT |
---|---|---|---|---|
SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
PIT@NE | PIT -116 | 60.1% | 6 | WIN |
ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
LV@WAS | LV +3 | 54.3% | 4 | LOSS |
GB@CLE | GB -7 | 54.3% | 4 | LOSS |
ARI@SF | ARI +3 | 57.7% | 6 | WIN |
KC@NYG | PATRICK MAHOMES OVER 230.5 PASS YDS | 54.7% | 4 | WIN |
GB@CLE | JOE FLACCO OVER 37.5 PASS ATT | 56.6% | 6 | LOSS |
MIA@BUF | TYREEK HILL OVER 5.5 TOTAL RECEPTIONS | 56.8% | 6 | LOSS |
LAC@LV | LAC -3 | 54.9% | 4 | WIN |
TB@HOU | BAKER MAYFIELD OVER 1.5 PASS TDS | 54.4% | 4 | WIN |
CHI@DET | DET -6.5 | 54.3% | 4 | WIN |
DEN@IND | DEN -118 | 60.1% | 10 | LOSS |
PHI@KC | PHI -115 | 56.7% | 6 | WIN |
SF@NO | SF -3 | 58.8% | 8 | WIN |
SEA@PIT | OVER 40 | 54.9% | 4 | WIN |
CAR@ARI | BRYCE YOUNG INTERCEPTIONS UNDER 0.5 | 56.4% | 6 | LOSS |
DEN@IND | JOSH DOWNS RECEPTIONS OVER 3.5 | 54.7% | 4 | WIN |
ATL@MIN | BIJAN ROBINSON RUSH + REC YDS OVER 94.5 | 53.4% | 3 | WIN |
WAS@GB | WAS +3.5 | 56.5% | 6 | LOSS |
WAS@GB | JORDAN LOVE OVER 5.5 RUSH YDS | 54.7% | 4 | WIN |
MIN@CHI | CALEB WILLIAMS OVER 219.5 PASS YDS | 53.4% | 3 | LOSS |
TEN@DEN | DEN -8.5 | 55.3% | 5 | LOSS |
SF@SEA | SF -115 | 54.6% | 4 | WIN |
SF@SEA | KENNETH WALKER III UNDER 79.5 RUSH+REC YDS | 54.6% | 4 | WIN |
CAR@JAC | TANK BIGSBY OVER 10.5 RUSH ATT | 56.1% | 6 | LOSS |
KC@LAC | JUSTIN HERBERT UNDER 0.5 INT | 54.1% | 3 | WIN |
DAL@PHI | GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS | 54.1% | 4 | LOSS |
KC@PHI | JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS | 53.90% | 5 | WIN |
KC@PHI | DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS | 54.40% | 6 | WIN |
KC@PHI | PATRICK MAHOMES UNDER 68.3% PASS COMP | 55.00% | 8 | WIN |
KC@PHI | JALEN HURTS LONGEST RUSH OVER 12.5 YDS | 55.60% | 8 | WIN |
BUF@KC | DALTON KINCAID OVER 29.5 RECV YDS | 55.10% | 8 | LOSS |
WAS@PHI | DEVONTA SMITH OVER 3.5 RECEPTIONS | 55.80% | 8 | WIN |
BUF@KC | JAMES COOK ANYTIME TD | 53.00% | 5 | WIN |
LAR@PHI | SAQUON BARKLEY UNDER 128 RUSH + REC YDS | 53.20% | 5 | LOSS |
BAL@BUF | LAMAR JACKSON OVER 54.5 RUSH YDS | 54.50% | 6 | LOSS |
HOU@KC | C.J. STROUD RUSH YDS UNDER 14.5 | 53.10% | 5 | LOSS |
WAS@DET | JAMESON WILLIAMS RUSH YDS OVER 1.5 | 53.30% | 5 | WIN |
WAS@DET | JARED GOFF PASS COMP % UNDER 72.3 | 54.30% | 6 | WIN |
MIN@LAR | COOPER KUPP ANYTIME TOUCHDOWN | 52.60% | 3 | LOSS |
MIN@LAR | MATTHEW STAFFORD OVER 21.5 PASS COMP | 54.10% | 6 | LOSS |
WAS@TB | BRIAN ROBINSON JR OVER 1.5 REC TARGETS | 53.50% | 5 | WIN |
WAS@TB | BAKER MAYFIELD UNDER 33.5 PASS ATT | 54.90% | 6 | WIN |
GB@PHI | JALEN HURTS OVER 67.1 PASS COMP PERCENTAGE | 54.60% | 6 | LOSS |
LAC@HOU | J.K. DOBBINS ANYTIME TD | 52.80% | 3 | LOSS |
LAC@HOU | LAC -2.5 | 53.40% | 3 | LOSS |
LAC@HOU | JUSTIN HERBERT OVER 19.5 RUSH YDS | 53.40% | 5 | LOSS |