Bills vs Colts Prediction — AI Finds CAN'T MISS NFL Lines & Props (Nov 10)

Updated: 2024-11-03T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Buffalo Bills (7-2) will visit the Indianapolis Colts (4-5) on November 10, 2024, at Lucas Oil Stadium. Both teams aim to bolster their playoff prospects in this crucial AFC matchup.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Nov 10, 2024

Start Time: 2:00 PM EST​

Venue: Lucas Oil Stadium​

Colts Record: (4-5)

Bills Record: (7-2)

OPENING ODDS

BUF Moneyline: -212

IND Moneyline: +177

BUF Spread: -4

IND Spread: +4.0

Over/Under: 47

BUF
Betting Trends

  • The Bills have covered the spread in 5 of their last 7 games, showcasing consistent performance against expectations.

IND
Betting Trends

  • The Colts have struggled at home, covering the spread in only 2 of their last 6 games at Lucas Oil Stadium.

MATCHUP TRENDS

  • In their last five head-to-head meetings, the underdog has covered the spread four times, indicating closely contested games between these teams.

BUF vs. IND
Best Prop Bet

  • Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.

LIVE NFL ODDS

NFL ODDS COMPARISON

WANT MORE AI PICKS?

VAULT
VS. SPREAD
325-240
VAULT
NET UNITS
(INCL VIG)
+395.4
VAULT
NET PROFIT
(INCL VIG)
$100/UNIT
$39,540
EXECUTIVE
VS. SPREAD
1593-1364
EXECUTIVE
NET UNITS
(INCL VIG)
+371.9
EXECUTIVE
NET PROFIT
(INCL VIG)
$100/UNIT
$37,192

AI SPORTS PICK PRODUCTS

Create a Free Account

‘Create an Account’ to Get Remi’s Picks Today.

Remi Finds New Picks

Remi calculates the probability a team will cover the line.

Remi Works 24/7

Remi uses this probability to assign units to each pick.

Get Remi's AI Picks

Get Remi’s Top AI Sports Picks sent direct to your inbox.

Buffalo vs Indianapolis Prediction & Odds:
Free NFL Betting Insights for 11/10/24

The upcoming clash between the Buffalo Bills and the Indianapolis Colts is set to be a pivotal encounter for both teams. The Bills, currently holding a 7-2 record, are riding a four-game winning streak and sit as the second seed in the AFC. Their recent victory over the Miami Dolphins was highlighted by a record-breaking 61-yard field goal from Tyler Bass. Quarterback Josh Allen continues to lead a potent offense, complemented by a defense that has been effective in limiting opponents’ scoring opportunities. Conversely, the Colts, standing at 4-5, have faced challenges, particularly at the quarterback position. Rookie Anthony Richardson’s need for further development has led to veteran Joe Flacco taking the helm. Despite Flacco’s experience, the Colts’ offense struggled in their recent 21-13 loss to the Minnesota Vikings, failing to score an offensive touchdown. Running back Jonathan Taylor remains a key asset, but the team’s overall offensive production has been inconsistent.

Defensively, the Colts have shown resilience, with notable performances from players like Grover Stewart, who recorded a strip-sack touchdown against the Vikings. However, containing dynamic offenses has been a challenge, as evidenced by their inability to limit the Vikings’ second-half surge. The Bills’ defense, on the other hand, has been formidable, effectively containing both the run and pass. Their ability to generate turnovers and apply pressure on opposing quarterbacks has been a cornerstone of their success. Special teams could also play a crucial role in this matchup. The Bills’ kicker, Tyler Bass, has demonstrated reliability and range, while the Colts’ special teams unit has had its share of inconsistencies. Coaching strategies will be under scrutiny, with the Bills’ staff likely focusing on exploiting the Colts’ defensive vulnerabilities and maintaining offensive momentum. The Colts’ coaching staff will need to devise a game plan that maximizes their offensive strengths while mitigating the Bills’ defensive pressure. Given the Bills’ current form and the Colts’ recent struggles, Buffalo enters this game as the favorite. However, the Colts’ home-field advantage and potential for offensive resurgence make them a team that cannot be underestimated. This game is expected to be a closely contested battle, with both teams looking to make a statement as the season progresses.

Buffalo Bills NFL Preview

The Buffalo Bills enter this matchup with a 7-2 record, riding a four-game winning streak that has solidified their position as one of the top teams in the AFC. Quarterback Josh Allen continues to be the catalyst for the offense, combining his arm strength and mobility to create explosive plays. In their recent victory over the Miami Dolphins, Allen orchestrated a game-winning drive that culminated in a record-breaking 61-yard field goal by Tyler Bass. The Bills’ receiving corps, featuring Stefon Diggs and Gabriel Davis, has been instrumental in stretching defenses and creating mismatches. The running game, led by James Cook, has provided balance, keeping opposing defenses honest. Defensively, the Bills have been formidable, ranking among the top in points allowed and defensive efficiency. Their ability to generate turnovers and apply pressure on opposing quarterbacks has been a cornerstone of their success. Linebacker Matt Milano and safety Jordan Poyer have been key contributors, providing leadership and playmaking ability. Special teams have also been a strength for the Bills, with kicker Tyler Bass demonstrating reliability and range and consistently converting crucial field goals, including his recent 61-yard game-winner against Miami. Bass’s accuracy and range add an extra layer of confidence for Buffalo’s offense, especially in close-game situations. Punter Sam Martin has also contributed positively to the field position battle, helping keep opposing teams in challenging starting positions. As they prepare to face the Colts, the Bills will focus on exploiting Indianapolis’s defensive vulnerabilities, particularly in pass coverage, where Josh Allen and his strong receiving corps can take advantage of potential mismatches. Establishing an effective ground game with James Cook will be essential to keep the Colts’ defense from focusing solely on Allen and the passing attack. Defensively, the Bills will aim to pressure Joe Flacco and disrupt the Colts’ offensive rhythm, especially by limiting Jonathan Taylor’s production in the running game. The Bills’ front seven, led by standout players like Matt Milano, will focus on closing running lanes and containing Taylor to force the Colts into more predictable passing situations. The coaching staff, led by Sean McDermott, will emphasize disciplined play and capitalizing on scoring opportunities early to establish momentum. The Bills enter this game with high confidence, aiming to extend their winning streak and maintain their position as a top contender in the AFC. By executing their game plan and leveraging their offensive firepower and defensive discipline, Buffalo hopes to secure a valuable road win and continue their march toward the postseason.

The Buffalo Bills (7-2) will visit the Indianapolis Colts (4-5) on November 10, 2024, at Lucas Oil Stadium. Both teams aim to bolster their playoff prospects in this crucial AFC matchup. Buffalo vs Indianapolis AI Prediction: Free NFL Betting Insights for Nov 10. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Indianapolis Colts NFL Preview

The Indianapolis Colts have experienced a tumultuous season, marked by a 4-5 record and ongoing challenges at the quarterback position. Rookie Anthony Richardson’s developmental needs have paved the way for veteran Joe Flacco to assume the starting role. Despite Flacco’s extensive experience, the offense has struggled to find consistency, as highlighted by their inability to score an offensive touchdown in the recent 21-13 loss to the Minnesota Vikings. Running back Jonathan Taylor remains a focal point of the Colts’ offensive strategy. However, without a balanced attack, defenses have been able to concentrate on containing Taylor, limiting his effectiveness. The receiving corps, led by Michael Pittman Jr., has shown potential, but inconsistent quarterback play has hindered their productivity. Defensively, the Colts have exhibited resilience, with standout performances from players like Grover Stewart, who recorded a strip-sack touchdown against the Vikings. Linebacker Zaire Franklin and safety Nick Cross have also contributed with key interceptions. Despite these individual efforts, the defense has faced challenges in containing dynamic offenses, particularly in the second half of games. Special teams have been a mixed bag for the Colts. While kicker Matt Gay has been reliable, the coverage units have allowed significant returns, putting additional pressure on the defense. As they prepare to host the Buffalo Bills, the Colts will need to address their offensive inconsistencies and develop a game plan that leverages their strengths. Establishing a balanced attack that incorporates both the run and pass will be crucial. Defensively, the focus will be on containing Josh Allen and the Bills’ high-powered offense, requiring disciplined play and effective communication. The coaching staff, led by head coach Shane Steichen, will be tasked with instilling confidence and executing a strategy that maximizes the team’s potential. With the support of the home crowd at Lucas Oil Stadium, the Colts have an opportunity to make a statement and turn their season around.

Buffalo vs. Indianapolis Prop Picks (AI)

AI algorithm Remi is pouring through loads of datapoints on each line. In fact, anytime the Bills and Colts play there’s always several intriguing trends to key in on. Not to mention games played at Lucas Oil Stadium in Nov almost always follow normal, predictable betting trends.
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.

Buffalo vs. Indianapolis Prediction (AI)

Remi Robot Icon

Remi, our AI sports algorithm, has been pouring over millions of data from every facet between the Bills and Colts and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.

The Algorithm has been most watching on the linear correlation of emphasis human bettors tend to put on player performance factors between a Bills team going up against a possibly tired Colts team. Trends look to say the true game analytics might reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Buffalo vs Indianapolis picks, computer picks Bills vs Colts, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NFL 10/20 HOU@SEA UNLOCK THIS PICK 5 INTEL Locked INTEL
NFL 10/20 TB@DET UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/20 TB@DET UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/20 TB@DET UNLOCK THIS PICK 1 INTEL Locked INTEL
NFL 10/20 HOU@SEA UNLOCK THIS PICK 0 INTEL Locked INTEL
NFL 10/20 TB@DET UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Bills Betting Trends

The Bills have covered the spread in 5 of their last 7 games, showcasing consistent performance against expectations.

Colts Betting Trends

The Colts have struggled at home, covering the spread in only 2 of their last 6 games at Lucas Oil Stadium.

Bills vs. Colts Matchup Trends

In their last five head-to-head meetings, the underdog has covered the spread four times, indicating closely contested games between these teams.

Buffalo vs. Indianapolis Game Info

Buffalo vs Indianapolis starts on November 10, 2024 at 2:00 PM EST.

Spread: Indianapolis +4.0
Moneyline: Buffalo -212, Indianapolis +177
Over/Under: 47

Buffalo: (7-2)  |  Indianapolis: (4-5)

Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.

In their last five head-to-head meetings, the underdog has covered the spread four times, indicating closely contested games between these teams.

BUF trend: The Bills have covered the spread in 5 of their last 7 games, showcasing consistent performance against expectations.

IND trend: The Colts have struggled at home, covering the spread in only 2 of their last 6 games at Lucas Oil Stadium.

See our latest NFL picks and odds pages for 2024 to compare prices before you bet.

Buffalo vs. Indianapolis Odds

Remi is pouring through tons of data points on each player. In fact, anytime the Buffalo vs Indianapolis trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable patterns.

Buffalo vs Indianapolis Opening Odds

BUF Moneyline: -212
IND Moneyline: +177
BUF Spread: -4
IND Spread: +4.0
Over/Under: 47

Buffalo vs Indianapolis Live Odds

Games PTS ML SPR O/U
Oct 23, 2025 8:15PM EDT
Minnesota Vikings
Los Angeles Chargers
10/23/25 8:15PM
Vikings
Chargers
+148
-185
+3 (+100)
-3 (-120)
O 44.5 (-110)
U 44.5 (-110)
Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
+270
-374
+7 (-110)
-7 (-110)
O 40.5 (-110)
U 40.5 (-110)
Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
-463
+321
-7.5 (-110)
+7.5 (-110)
O 46 (-110)
U 46 (-110)
Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
+242
-330
+7 (-110)
-7 (-110)
O 44.5 (-110)
U 44.5 (-110)
Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
+229
-315
+6.5 (+100)
-6.5 (-120)
O 50.5 (-110)
U 50.5 (-110)
Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
+287
-407
+7 (-110)
-7 (-110)
O 43.5 (-110)
U 43.5 (-110)
Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
-110
-116
+1 (-110)
-1 (-110)
O 41.5 (-110)
U 41.5 (-110)
Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
+257
-355
+7 (-110)
-7 (-110)
O 44.5 (-110)
U 44.5 (-110)
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
-220
+169
-4.5 (-110)
+4.5 (-110)
O 47 (-110)
U 47 (-110)
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
+141
-181
+3.5 (-120)
-3.5 (+100)
O 50 (-110)
U 50 (-110)
Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
+682
-1442
+14 (-110)
-14 (-110)
O 47 (-110)
U 47 (-110)
Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
-192
+148
-3.5 (+100)
+3.5 (-120)
O 44.5 (-110)
U 44.5 (-110)
Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
+390
-599
+10.5 (-110)
-10.5 (-110)
O 47.5 (-110)
U 47.5 (-110)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Buffalo Bills vs. Indianapolis Colts on November 10, 2024 at Lucas Oil Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS
HOU@BAL HOU -125 58.5% 7 WIN
DET@CIN DET -10 55.6% 5 WIN
DAL@NYJ NYJ +1.5 53.7% 3 LOSS
TB@SEA TB +3.5 54.9% 4 WIN
TEN@ARI ARI -7 (BUY 0.5) 54.9% 4 LOSS
DEN@PHI DEN +4.5 57.5% 7 WIN
MIA@CAR TETAIROA MCMILLAN OVER 58.5 RECV YDS 54.5% 4 WIN
LV@IND ASHTON JEANTY UNDER 67.5 RUSH YDS 54.4% 4 WIN
SF@LAR DEMARCUS ROBINSON OVER 29.5 RECV YDS 55.7% 5 WIN
NYJ@MIA NYJ +3 53.8 3 LOSS
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS
TEN@HOU TEN +7.5 57.9% 7 LOSS
LAC@NYG LAC -6 57.3% 7 LOSS
NO@BUF UNDER 48.5 55.1% 3 LOSS
GB@DAL JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS 55.5% 5 LOSS
CAR@NE DRAKE MAYE TO THROW AN INT 56.6% 6 LOSS
SEA@ARI SEA -125 57.7% 6 WIN
SEA@ARI KYLER MURRAY TO THROW AN INT 56.6% 6 WIN
DET@BAL JAHMYR GIBBS OVER 0.5 RUSH TDS 55.8% 5 WIN
DAL@CHI DAL -120 58.7% 6 LOSS
PIT@NE PIT -116 60.1% 6 WIN
ATL@CAR ATL -4.5 55.4% 5 LOSS
LV@WAS LV +3 54.3% 4 LOSS