Chargers vs. Cardinals
Prediction, Odds & Props
Oct 21 | NFL AI Picks
Updated: 2024-10-14T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
On October 21, 2024, the Los Angeles Chargers (3-2) will face the Arizona Cardinals (2-4) at State Farm Stadium. The Chargers are looking to stay competitive in the AFC West, while the Cardinals hope to bounce back after a tough start to the season.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Oct 21, 2024
Start Time: 9:00 PM EST
Venue: State Farm Stadium
Cardinals Record:
Chargers Record:
OPENING ODDS
LAC Moneyline: -147
ARI Moneyline: +124
LAC Spread: -2.5
ARI Spread: +2.5
Over/Under: 44
LAC
Betting Trends
- The Chargers have been strong against the spread (ATS) this season, covering in three of their last five games. Their ability to move the ball effectively, combined with solid defensive play, has kept them competitive in most of their matchups.
ARI
Betting Trends
- The Cardinals have struggled ATS, covering in just two of their last six games. Their inconsistency, especially on offense, has made it difficult for bettors to trust them, particularly at home where they’ve faced challenges putting points on the board.
MATCHUP TRENDS
- The total points over/under is set at 43.5 for this matchup. Both teams have leaned towards lower-scoring games, with the Chargers’ defense playing well and Arizona’s offense struggling to find consistency this season. As a result, games involving these two teams have often gone under the projected total.
LAC vs. ARI
Best Prop Bet
- Remi searched hard and found the best prop bet prediction for this matchup: Justin Herbert Over 195.5 Passing Yards
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Los Angeles vs Arizona Prediction & Odds:
Free NFL Betting Insights for 10/21/24
Arizona, meanwhile, has had a difficult season so far. The return of Kyler Murray from injury hasn’t provided the spark many expected. He has thrown for over 1,000 yards but has struggled with turnovers, which has derailed the Cardinals’ offensive drives. Their running game, led by James Conner, has been solid, but it hasn’t been enough to cover for their inconsistencies through the air. This game will likely come down to the ability of the Cardinals’ offense to break through against a tough Chargers defense. If Murray can limit his mistakes and take advantage of some of the mismatches against the Chargers’ secondary, Arizona could keep the game competitive. However, given how well the Chargers have played both offensively and defensively, they are favored to win this matchup.
workin' 😁 pic.twitter.com/8xTaGTXJyy
— Los Angeles Chargers (@chargers) October 17, 2024
Los Angeles Chargers NFL Preview
The Los Angeles Chargers are 3-2 and aiming to build on their strong start to the 2024 season. Justin Herbert has been at the center of the team’s success, throwing for over 1,200 yards and providing a steady hand for the offense. Herbert’s connection with wide receivers like Quentin Johnston has helped the Chargers develop a balanced offensive attack. Additionally, J.K. Dobbins has been effective on the ground, giving the Chargers the versatility needed to compete against tough defenses. Defensively, the Chargers have been solid, especially in getting to the quarterback. Joey Bosa and Khalil Mack lead a pass rush that has caused problems for opposing offenses, while Derwin James continues to be a force in the secondary. This defensive unit will look to exploit Arizona’s offensive struggles and force turnovers. If the Chargers can keep the Cardinals’ offense in check and execute their game plan on both sides of the ball, they should be able to secure a road victory in Arizona.
Credit: USA TODAY/IMAGN
Arizona Cardinals NFL Preview
The Arizona Cardinals enter this Week 7 matchup against the Chargers with a 2-4 record and are desperate to turn their season around. The return of Kyler Murray has been a focal point for the Cardinals, but his struggles with turnovers and inconsistency in moving the ball have hindered the team’s progress. Murray has flashed his dynamic playmaking ability but has also thrown key interceptions in tight games. James Conner has been one of the bright spots for Arizona’s offense, leading the team with over 400 rushing yards. He will need to have a big game to relieve some of the pressure off Murray and keep the Chargers’ defense honest. Arizona’s defense, led by safety Budda Baker, has also had its ups and downs. They’ve been good at stopping the run, but the secondary has given up too many big plays. For the Cardinals to pull off an upset, they’ll need to limit the Chargers’ big plays and control the time of possession. This game will be critical in determining whether Arizona can remain in the playoff hunt.
can't forget the details pic.twitter.com/nbTnUyij9b
— Arizona Cardinals (@AZCardinals) October 16, 2024
Los Angeles vs. Arizona Prop Picks (AI)
Los Angeles vs. Arizona Prediction (AI)
Remi, our AI sports wizard, has been pouring over millions of data from every past game between the Chargers and Cardinals and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.
The Algorithm has been most watching on the unproportionally assigned factor knucklehead sportsbettors tend to put on coaching factors between a Chargers team going up against a possibly rested Cardinals team. Trends look to say the true game analytics might reflect a moderate lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Los Angeles vs Arizona picks, computer picks Chargers vs Cardinals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Chargers Betting Trends
The Chargers have been strong against the spread (ATS) this season, covering in three of their last five games. Their ability to move the ball effectively, combined with solid defensive play, has kept them competitive in most of their matchups.
Cardinals Betting Trends
The Cardinals have struggled ATS, covering in just two of their last six games. Their inconsistency, especially on offense, has made it difficult for bettors to trust them, particularly at home where they’ve faced challenges putting points on the board.
Chargers vs. Cardinals Matchup Trends
The total points over/under is set at 43.5 for this matchup. Both teams have leaned towards lower-scoring games, with the Chargers’ defense playing well and Arizona’s offense struggling to find consistency this season. As a result, games involving these two teams have often gone under the projected total.
Los Angeles vs. Arizona Game Info
What time does Los Angeles vs Arizona start on October 21, 2024?
Los Angeles vs Arizona starts on October 21, 2024 at 9:00 PM EST.
Where is Los Angeles vs Arizona being played?
Venue: State Farm Stadium.
What are the opening odds for Los Angeles vs Arizona?
Spread: Arizona +2.5
Moneyline: Los Angeles -147, Arizona +124
Over/Under: 44
What are the records for Los Angeles vs Arizona?
Los Angeles: | Arizona:
What is the AI best bet for Los Angeles vs Arizona?
Remi searched hard and found the best prop bet prediction for this matchup: Justin Herbert Over 195.5 Passing Yards. Prices move—always shop for the best number.
What are Los Angeles vs Arizona trending bets?
The total points over/under is set at 43.5 for this matchup. Both teams have leaned towards lower-scoring games, with the Chargers’ defense playing well and Arizona’s offense struggling to find consistency this season. As a result, games involving these two teams have often gone under the projected total.
What are Los Angeles trending bets?
LAC trend: The Chargers have been strong against the spread (ATS) this season, covering in three of their last five games. Their ability to move the ball effectively, combined with solid defensive play, has kept them competitive in most of their matchups.
What are Arizona trending bets?
ARI trend: The Cardinals have struggled ATS, covering in just two of their last six games. Their inconsistency, especially on offense, has made it difficult for bettors to trust them, particularly at home where they’ve faced challenges putting points on the board.
Where can I find AI Picks for Los Angeles vs Arizona?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
Los Angeles vs. Arizona Odds
Remi is pouring through loads of data points on each team. In fact, anytime the Los Angeles vs Arizona trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable betting trends.
Los Angeles vs Arizona Opening Odds
LAC Moneyline:
-147 ARI Moneyline: +124
LAC Spread: -2.5
ARI Spread: +2.5
Over/Under: 44
Los Angeles vs Arizona Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Sep 28, 2025 9:31AM EDT
Minnesota Vikings
Pittsburgh Steelers
9/28/25 9:31AM
Vikings
Steelers
|
–
–
|
-140
+115
|
-2.5 (-115)
+2.5 (-105)
|
O 41 (-110)
U 41 (-110)
|
|
|
Sep 28, 2025 1:00PM EDT
Cleveland Browns
Detroit Lions
9/28/25 1PM
Browns
Lions
|
–
–
|
+400
-550
|
+10 (-110)
-10 (-110)
|
O 44.5 (-105)
U 44.5 (-115)
|
|
|
Sep 28, 2025 1:00PM EDT
Los Angeles Chargers
New York Giants
9/28/25 1PM
Chargers
Giants
|
–
–
|
-285
+230
|
-6.5 (-105)
+6.5 (-115)
|
O 44 (-110)
U 44 (-110)
|
|
|
Sep 28, 2025 1:01PM EDT
Tennessee Titans
Houston Texans
9/28/25 1:01PM
Titans
Texans
|
–
–
|
+300
-375
|
+7 (-105)
-7 (-115)
|
O 39 (-110)
U 39 (-110)
|
|
|
Sep 28, 2025 1:01PM EDT
Philadelphia Eagles
Tampa Bay Buccaneers
9/28/25 1:01PM
Eagles
Buccaneers
|
–
–
|
-190
+160
|
-3.5 (-105)
+3.5 (-115)
|
O 44 (-110)
U 44 (-110)
|
|
|
Sep 28, 2025 1:01PM EDT
Washington Commanders
Atlanta Falcons
9/28/25 1:01PM
Commanders
Falcons
|
–
–
|
+110
-130
|
+2 (-110)
-2 (-110)
|
O 43.5 (-110)
U 43.5 (-110)
|
|
|
Sep 28, 2025 1:01PM EDT
New Orleans Saints
Buffalo Bills
9/28/25 1:01PM
Saints
Bills
|
–
–
|
+800
-1300
|
+15 (-110)
-15 (-110)
|
O 48 (-110)
U 48 (-110)
|
|
|
Sep 28, 2025 1:01PM EDT
Carolina Panthers
New England Patriots
9/28/25 1:01PM
Panthers
Patriots
|
–
–
|
+200
-250
|
+5.5 (-110)
-5.5 (-110)
|
O 43 (-110)
U 43 (-110)
|
|
|
Sep 28, 2025 4:06PM EDT
Jacksonville Jaguars
San Francisco 49ers
9/28/25 4:06PM
Jaguars
49ers
|
–
–
|
+150
-180
|
+3.5 (-115)
-3.5 (-105)
|
O 46.5 (-110)
U 46.5 (-110)
|
|
|
Sep 28, 2025 4:06PM EDT
Indianapolis Colts
Los Angeles Rams
9/28/25 4:06PM
Colts
Rams
|
–
–
|
+160
-190
|
+3.5 (-110)
-3.5 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
|
Sep 28, 2025 4:25PM EDT
Baltimore Ravens
Kansas City Chiefs
9/28/25 4:25PM
Ravens
Chiefs
|
–
–
|
-150
+125
|
-2.5 (-120)
+2.5 (+100)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
|
Sep 28, 2025 4:26PM EDT
Chicago Bears
Las Vegas Raiders
9/28/25 4:26PM
Bears
Raiders
|
–
–
|
+100
-120
|
+1 (-110)
-1 (-110)
|
O 48 (-110)
U 48 (-110)
|
|
|
Sep 28, 2025 8:21PM EDT
Green Bay Packers
Dallas Cowboys
9/28/25 8:21PM
Packers
Cowboys
|
–
–
|
-325
+250
|
-7 (-105)
+7 (-115)
|
O 47 (-110)
U 47 (-110)
|
|
|
Sep 29, 2025 7:15PM EDT
New York Jets
Miami Dolphins
9/29/25 7:15PM
Jets
Dolphins
|
–
–
|
+125
-150
|
+3 (-115)
-3 (-105)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Sep 29, 2025 8:15PM EDT
Cincinnati Bengals
Denver Broncos
9/29/25 8:15PM
Bengals
Broncos
|
–
–
|
+310
-400
|
+7.5 (-110)
-7.5 (-110)
|
O 44 (-110)
U 44 (-110)
|
|
|
Oct 2, 2025 8:16PM EDT
San Francisco 49ers
Los Angeles Rams
10/2/25 8:16PM
49ers
Rams
|
–
–
|
+134
-158
|
+3 (-105)
-3 (-115)
|
O 47 (-110)
U 47 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Los Angeles Chargers vs. Arizona Cardinals on October 21, 2024 at State Farm Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |
| GB@CLE | GB -7 | 54.3% | 4 | LOSS |
| ARI@SF | ARI +3 | 57.7% | 6 | WIN |
| KC@NYG | PATRICK MAHOMES OVER 230.5 PASS YDS | 54.7% | 4 | WIN |
| GB@CLE | JOE FLACCO OVER 37.5 PASS ATT | 56.6% | 6 | LOSS |
| MIA@BUF | TYREEK HILL OVER 5.5 TOTAL RECEPTIONS | 56.8% | 6 | LOSS |
| LAC@LV | LAC -3 | 54.9% | 4 | WIN |
| TB@HOU | BAKER MAYFIELD OVER 1.5 PASS TDS | 54.4% | 4 | WIN |
| CHI@DET | DET -6.5 | 54.3% | 4 | WIN |
| DEN@IND | DEN -118 | 60.1% | 10 | LOSS |
| PHI@KC | PHI -115 | 56.7% | 6 | WIN |
| SF@NO | SF -3 | 58.8% | 8 | WIN |
| SEA@PIT | OVER 40 | 54.9% | 4 | WIN |
| CAR@ARI | BRYCE YOUNG INTERCEPTIONS UNDER 0.5 | 56.4% | 6 | LOSS |
| DEN@IND | JOSH DOWNS RECEPTIONS OVER 3.5 | 54.7% | 4 | WIN |
| ATL@MIN | BIJAN ROBINSON RUSH + REC YDS OVER 94.5 | 53.4% | 3 | WIN |
| WAS@GB | WAS +3.5 | 56.5% | 6 | LOSS |
| WAS@GB | JORDAN LOVE OVER 5.5 RUSH YDS | 54.7% | 4 | WIN |
| MIN@CHI | CALEB WILLIAMS OVER 219.5 PASS YDS | 53.4% | 3 | LOSS |
| TEN@DEN | DEN -8.5 | 55.3% | 5 | LOSS |
| SF@SEA | SF -115 | 54.6% | 4 | WIN |
| SF@SEA | KENNETH WALKER III UNDER 79.5 RUSH+REC YDS | 54.6% | 4 | WIN |
| CAR@JAC | TANK BIGSBY OVER 10.5 RUSH ATT | 56.1% | 6 | LOSS |
| KC@LAC | JUSTIN HERBERT UNDER 0.5 INT | 54.1% | 3 | WIN |
| DAL@PHI | GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS | 54.1% | 4 | LOSS |
| KC@PHI | JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS | 53.90% | 5 | WIN |
| KC@PHI | DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS | 54.40% | 6 | WIN |
| KC@PHI | PATRICK MAHOMES UNDER 68.3% PASS COMP | 55.00% | 8 | WIN |
| KC@PHI | JALEN HURTS LONGEST RUSH OVER 12.5 YDS | 55.60% | 8 | WIN |
| BUF@KC | DALTON KINCAID OVER 29.5 RECV YDS | 55.10% | 8 | LOSS |
| WAS@PHI | DEVONTA SMITH OVER 3.5 RECEPTIONS | 55.80% | 8 | WIN |
| BUF@KC | JAMES COOK ANYTIME TD | 53.00% | 5 | WIN |
| LAR@PHI | SAQUON BARKLEY UNDER 128 RUSH + REC YDS | 53.20% | 5 | LOSS |
| BAL@BUF | LAMAR JACKSON OVER 54.5 RUSH YDS | 54.50% | 6 | LOSS |
| HOU@KC | C.J. STROUD RUSH YDS UNDER 14.5 | 53.10% | 5 | LOSS |
| WAS@DET | JAMESON WILLIAMS RUSH YDS OVER 1.5 | 53.30% | 5 | WIN |
| WAS@DET | JARED GOFF PASS COMP % UNDER 72.3 | 54.30% | 6 | WIN |
| MIN@LAR | COOPER KUPP ANYTIME TOUCHDOWN | 52.60% | 3 | LOSS |
| MIN@LAR | MATTHEW STAFFORD OVER 21.5 PASS COMP | 54.10% | 6 | LOSS |
| WAS@TB | BRIAN ROBINSON JR OVER 1.5 REC TARGETS | 53.50% | 5 | WIN |
| WAS@TB | BAKER MAYFIELD UNDER 33.5 PASS ATT | 54.90% | 6 | WIN |
| GB@PHI | JALEN HURTS OVER 67.1 PASS COMP PERCENTAGE | 54.60% | 6 | LOSS |
| LAC@HOU | J.K. DOBBINS ANYTIME TD | 52.80% | 3 | LOSS |
| LAC@HOU | LAC -2.5 | 53.40% | 3 | LOSS |
| LAC@HOU | JUSTIN HERBERT OVER 19.5 RUSH YDS | 53.40% | 5 | LOSS |