Chargers vs Cardinals Prediction — AI Finds CAN'T MISS NFL Lines & Props (Oct 21)
Updated: 2024-10-14T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
On October 21, 2024, the Los Angeles Chargers (3-2) will face the Arizona Cardinals (2-4) at State Farm Stadium. The Chargers are looking to stay competitive in the AFC West, while the Cardinals hope to bounce back after a tough start to the season.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Oct 21, 2024
Start Time: 9:00 PM EST
Venue: State Farm Stadium
Cardinals Record:
Chargers Record:
OPENING ODDS
LAC Moneyline: -147
ARI Moneyline: +124
LAC Spread: -2.5
ARI Spread: +2.5
Over/Under: 44
LAC
Betting Trends
- The Chargers have been strong against the spread (ATS) this season, covering in three of their last five games. Their ability to move the ball effectively, combined with solid defensive play, has kept them competitive in most of their matchups.
ARI
Betting Trends
- The Cardinals have struggled ATS, covering in just two of their last six games. Their inconsistency, especially on offense, has made it difficult for bettors to trust them, particularly at home where they’ve faced challenges putting points on the board.
MATCHUP TRENDS
- The total points over/under is set at 43.5 for this matchup. Both teams have leaned towards lower-scoring games, with the Chargers’ defense playing well and Arizona’s offense struggling to find consistency this season. As a result, games involving these two teams have often gone under the projected total.
LAC vs. ARI
Best Prop Bet
- Remi searched hard and found the best prop bet prediction for this matchup: Justin Herbert Over 195.5 Passing Yards
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Los Angeles vs Arizona Prediction & Odds:
Free NFL Betting Insights for 10/21/24
Arizona, meanwhile, has had a difficult season so far. The return of Kyler Murray from injury hasn’t provided the spark many expected. He has thrown for over 1,000 yards but has struggled with turnovers, which has derailed the Cardinals’ offensive drives. Their running game, led by James Conner, has been solid, but it hasn’t been enough to cover for their inconsistencies through the air. This game will likely come down to the ability of the Cardinals’ offense to break through against a tough Chargers defense. If Murray can limit his mistakes and take advantage of some of the mismatches against the Chargers’ secondary, Arizona could keep the game competitive. However, given how well the Chargers have played both offensively and defensively, they are favored to win this matchup.
workin' 😁 pic.twitter.com/8xTaGTXJyy
— Los Angeles Chargers (@chargers) October 17, 2024
Los Angeles Chargers NFL Preview
The Los Angeles Chargers are 3-2 and aiming to build on their strong start to the 2024 season. Justin Herbert has been at the center of the team’s success, throwing for over 1,200 yards and providing a steady hand for the offense. Herbert’s connection with wide receivers like Quentin Johnston has helped the Chargers develop a balanced offensive attack. Additionally, J.K. Dobbins has been effective on the ground, giving the Chargers the versatility needed to compete against tough defenses. Defensively, the Chargers have been solid, especially in getting to the quarterback. Joey Bosa and Khalil Mack lead a pass rush that has caused problems for opposing offenses, while Derwin James continues to be a force in the secondary. This defensive unit will look to exploit Arizona’s offensive struggles and force turnovers. If the Chargers can keep the Cardinals’ offense in check and execute their game plan on both sides of the ball, they should be able to secure a road victory in Arizona.
Credit: USA TODAY/IMAGN
Arizona Cardinals NFL Preview
The Arizona Cardinals enter this Week 7 matchup against the Chargers with a 2-4 record and are desperate to turn their season around. The return of Kyler Murray has been a focal point for the Cardinals, but his struggles with turnovers and inconsistency in moving the ball have hindered the team’s progress. Murray has flashed his dynamic playmaking ability but has also thrown key interceptions in tight games. James Conner has been one of the bright spots for Arizona’s offense, leading the team with over 400 rushing yards. He will need to have a big game to relieve some of the pressure off Murray and keep the Chargers’ defense honest. Arizona’s defense, led by safety Budda Baker, has also had its ups and downs. They’ve been good at stopping the run, but the secondary has given up too many big plays. For the Cardinals to pull off an upset, they’ll need to limit the Chargers’ big plays and control the time of possession. This game will be critical in determining whether Arizona can remain in the playoff hunt.
can't forget the details pic.twitter.com/nbTnUyij9b
— Arizona Cardinals (@AZCardinals) October 16, 2024
Los Angeles vs. Arizona Prop Picks (AI)
Los Angeles vs. Arizona Prediction (AI)
Remi, our AI sports genius, has been pouring over millions of data from every simulation between the Chargers and Cardinals and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.
The Algorithm has been most focused on the trending weight human bettors often put on player performance factors between a Chargers team going up against a possibly tired Cardinals team. We’ve found the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Los Angeles vs Arizona picks, computer picks Chargers vs Cardinals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 6 |
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| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 4 |
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| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 4 |
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| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 1 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Chargers Betting Trends
The Chargers have been strong against the spread (ATS) this season, covering in three of their last five games. Their ability to move the ball effectively, combined with solid defensive play, has kept them competitive in most of their matchups.
Cardinals Betting Trends
The Cardinals have struggled ATS, covering in just two of their last six games. Their inconsistency, especially on offense, has made it difficult for bettors to trust them, particularly at home where they’ve faced challenges putting points on the board.
Chargers vs. Cardinals Matchup Trends
The total points over/under is set at 43.5 for this matchup. Both teams have leaned towards lower-scoring games, with the Chargers’ defense playing well and Arizona’s offense struggling to find consistency this season. As a result, games involving these two teams have often gone under the projected total.
Los Angeles vs. Arizona Game Info
What time does Los Angeles vs Arizona start on October 21, 2024?
Los Angeles vs Arizona starts on October 21, 2024 at 9:00 PM EST.
Where is Los Angeles vs Arizona being played?
Venue: State Farm Stadium.
What are the opening odds for Los Angeles vs Arizona?
Spread: Arizona +2.5
Moneyline: Los Angeles -147, Arizona +124
Over/Under: 44
What are the records for Los Angeles vs Arizona?
Los Angeles: | Arizona:
What is the AI best bet for Los Angeles vs Arizona?
Remi searched hard and found the best prop bet prediction for this matchup: Justin Herbert Over 195.5 Passing Yards. Prices move—always shop for the best number.
What are Los Angeles vs Arizona trending bets?
The total points over/under is set at 43.5 for this matchup. Both teams have leaned towards lower-scoring games, with the Chargers’ defense playing well and Arizona’s offense struggling to find consistency this season. As a result, games involving these two teams have often gone under the projected total.
What are Los Angeles trending bets?
LAC trend: The Chargers have been strong against the spread (ATS) this season, covering in three of their last five games. Their ability to move the ball effectively, combined with solid defensive play, has kept them competitive in most of their matchups.
What are Arizona trending bets?
ARI trend: The Cardinals have struggled ATS, covering in just two of their last six games. Their inconsistency, especially on offense, has made it difficult for bettors to trust them, particularly at home where they’ve faced challenges putting points on the board.
Where can I find AI Picks for Los Angeles vs Arizona?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
Los Angeles vs. Arizona Odds
Remi is pouring through mountains of data points on each line. In fact, anytime the Los Angeles vs Arizona trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme altitude can often follow normal, predictable patterns.
Los Angeles vs Arizona Opening Odds
LAC Moneyline:
-147 ARI Moneyline: +124
LAC Spread: -2.5
ARI Spread: +2.5
Over/Under: 44
Los Angeles vs Arizona Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
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Nov 10, 2025 8:15PM EST
Philadelphia Eagles
Green Bay Packers
11/10/25 8:15PM
Eagles
Packers
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–
–
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-105
-115
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-1 (-110)
+1 (-110)
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O 45 (-110)
U 45 (-110)
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+550
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O 43 (-115)
U 43 (-105)
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–
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+130
-150
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+2.5 (+100)
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O 47.5 (-110)
U 47.5 (-110)
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Atlanta Falcons
11/16/25 1PM
Panthers
Falcons
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–
–
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+165
-195
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+3.5 (-115)
-3.5 (-105)
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O 42.5 (-110)
U 42.5 (-110)
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Nov 16, 2025 1:00PM EST
Chicago Bears
Minnesota Vikings
11/16/25 1PM
Bears
Vikings
|
–
–
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+140
-165
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+3 (-110)
-3 (-110)
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O 48 (-110)
U 48 (-110)
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Nov 16, 2025 1:00PM EST
Los Angeles Chargers
Jacksonville Jaguars
11/16/25 1PM
Chargers
Jaguars
|
–
–
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-150
+130
|
-3 (+100)
+3 (-120)
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O 44 (-110)
U 44 (-110)
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Nov 16, 2025 1:00PM EST
Green Bay Packers
New York Giants
11/16/25 1PM
Packers
Giants
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–
–
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-460
+360
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-7.5 (-120)
+7.5 (-102)
|
O 44.5 (-110)
U 44.5 (-110)
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Nov 16, 2025 1:00PM EST
Cincinnati Bengals
Pittsburgh Steelers
11/16/25 1PM
Bengals
Steelers
|
–
–
|
+205
-245
|
+5.5 (-110)
-5.5 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
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Nov 16, 2025 1:00PM EST
Tampa Bay Buccaneers
Buffalo Bills
11/16/25 1PM
Buccaneers
Bills
|
–
–
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+225
-275
|
+5.5 (-110)
-5.5 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
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Nov 16, 2025 1:00PM EST
Houston Texans
Tennessee Titans
11/16/25 1PM
Texans
Titans
|
–
–
|
-370
+285
|
-7 (-110)
+7 (-110)
|
O 39.5 (-105)
U 39.5 (-115)
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Nov 16, 2025 4:05PM EST
San Francisco 49ers
Arizona Cardinals
11/16/25 4:05PM
49ers
Cardinals
|
–
–
|
-150
+130
|
-2.5 (-120)
+2.5 (+100)
|
O 49 (-115)
U 49 (-105)
|
|
|
Nov 16, 2025 4:05PM EST
Seattle Seahawks
Los Angeles Rams
11/16/25 4:05PM
Seahawks
Rams
|
–
–
|
+130
-150
|
+2.5 (+100)
-2.5 (-120)
|
O 48 (-115)
U 48 (-105)
|
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Nov 16, 2025 4:25PM EST
Kansas City Chiefs
Denver Broncos
11/16/25 4:25PM
Chiefs
Broncos
|
–
–
|
-210
+175
|
-4 (-110)
+4 (-110)
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O 44.5 (-115)
U 44.5 (-105)
|
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Nov 16, 2025 4:25PM EST
Baltimore Ravens
Cleveland Browns
11/16/25 4:25PM
Ravens
Browns
|
–
–
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-470
+345
|
-8 (-110)
+8 (-110)
|
O 41.5 (-115)
U 41.5 (-105)
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Nov 16, 2025 8:20PM EST
Detroit Lions
Philadelphia Eagles
11/16/25 8:20PM
Lions
Eagles
|
–
–
|
+104
-122
|
+1.5 (-112)
-1.5 (-108)
|
O 48.5 (-110)
U 48.5 (-110)
|
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Nov 17, 2025 8:15PM EST
Dallas Cowboys
Las Vegas Raiders
11/17/25 8:15PM
Cowboys
Raiders
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–
–
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-185
+160
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-3.5 (+100)
+3.5 (-120)
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O 50 (-110)
U 50 (-110)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Los Angeles Chargers vs. Arizona Cardinals on October 21, 2024 at State Farm Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| LV@DEN | RILEY MOSS OVER 4.5 TACKLE + ASST | 54.8% | 4 | WIN |
| LV@DEN | UNDER 43 | 53.4% | 2 | WIN |
| ARI@DAL | BUDDA BAKER OVER 7.5 TACKLES + ASSTS | 54.4% | 4 | WIN |
| ARI@DAL | GEORGE PICKENS OVER 4.5 RECEPTIONS | 56.6% | 6 | WIN |
| DEN@HOU | WIL LUTZ OVER 1.5 MADE FIELD GOALS | 54.2% | 3 | LOSS |
| SEA@WAS | SEA -3 | 56.7% | 6 | WIN |
| IND@PIT | IND -3 | 56.8% | 6 | LOSS |
| LAC@TEN | LAC -9.5 | 56.2% | 6 | LOSS |
| CHI@CIN | CHI -2.5 | 52.6% | 2 | WIN |
| SEA@WAS | OVER 48 | 52.9% | 2 | WIN |
| SEA@WAS | JAYDEN DANIELS OVER 20.5 PASS COMP | 56.7% | 6 | LOSS |
| JAC@LV | JAC -140 | 64.2% | 7 | WIN |
| NO@LAR | LAR -14 | 55.0% | 4 | WIN |
| DEN@HOU | HOU -1.5 | 54.2% | 3 | LOSS |
| CAR@GB | GB -12.5 | 55.4% | 5 | LOSS |
| SF@NYG | NYG +2.5 | 56.1% | 5 | LOSS |
| BAL@MIA | TUA TAGOVAILOA UNDER 0.5 INT | 55.3% | 5 | LOSS |
| TB@NO | TB -3.5 | 52.3% | 1 | WIN |
| GB@PIT | GB -2.5 | 52.3% | 1 | WIN |
| SF@HOU | SF +2.5 | 56.0% | 6 | LOSS |
| NYG@PHI | NYG +7.5 | 53.9% | 3 | LOSS |
| BUF@CAR | CAR +7.5 | 54.2% | 3 | LOSS |
| DAL@DEN | DAL +3.5 | 55.0% | 4 | LOSS |
| MIA@ATL | MIA +7 | 54.3% | 4 | WIN |
| CLE@NE | CLE +7 | 56.8% | 6 | LOSS |
| TB@NO | BAKER MAYFIELD OVER 15.5 RUSH YDS | 56.6% | 6 | LOSS |
| MIN@LAC | JUSTIN HERBERT PASS ATT UNDER 35.5 | 55.5% | 5 | WIN |
| TB@DET | TB +6.5 | 54.4% | 4 | LOSS |
| TB@DET | RACHAAD WHITE UNDER 14.5 RUSH ATT | 54.4% | 4 | WIN |
| NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
| CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
| PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
| GB@ARI | ARI +7 | 54.8% | 5 | WIN |
| NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
| WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
| GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
| PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
| BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
| CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
| TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
| DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
| SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
| LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
| ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
| TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
| LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
| SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
| CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
| DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
| KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
| KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |