Chiefs vs 49ers Prediction — AI Finds CAN'T MISS NFL Lines & Props (Oct 20)

Updated: 2024-10-13T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Kansas City Chiefs, undefeated at 5-0, will face the San Francisco 49ers, currently 3-3, at Levi’s Stadium on October 20, 2024. The Chiefs, led by Patrick Mahomes, aim to stay perfect, while the 49ers, featuring Brock Purdy, seek to snap their recent skid in what could be a thrilling offensive showdown.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Oct 20, 2024

Start Time: 4:25 PM EST​

Venue: Levi's Stadium​

49ers Record:

Chiefs Record:

OPENING ODDS

KC Moneyline: +101

SF Moneyline: -121

KC Spread: +1.5

SF Spread: -1.5

Over/Under: 47

KC
Betting Trends

  • The Chiefs have been strong against the spread (ATS), covering in 7 of their last 10 games. Their high-powered offense and Mahomes’ playmaking ability make them a solid bet, even when favored on the road.

SF
Betting Trends

  • The 49ers have been slightly better ATS at home, covering 6 times in their last 10 games. Their dominant rushing attack, led by Jordan Mason, has helped control games at Levi’s Stadium .

MATCHUP TRENDS

  • The over/under is set at 47.5 points. Both teams boast top offenses—San Francisco ranks 3rd in total offense while Kansas City sits at 11th. Given both teams’ explosive playmakers, the over has hit in several recent matchups involving these squads.

KC vs. SF
Best Prop Bet

  • Remi searched hard and found the best prop bet prediction for this matchup: George Kittle Over 48.5 Total Receiving Yards

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Kansas City vs San Francisco Prediction & Odds:
Free NFL Betting Insights for 10/20/24

The Kansas City Chiefs and San Francisco 49ers are set to clash in a marquee Week 7 matchup on October 20, 2024. The game, taking place at Levi’s Stadium, pits the unbeaten Chiefs (5-0) against the 3-3 49ers in what could be a potential playoff preview. Both teams come into the game with potent offenses and defenses capable of making game-changing plays, setting up a thrilling contest.

The Chiefs, led by quarterback Patrick Mahomes, have looked dominant through the first five weeks. Mahomes has passed for 1,235 yards and 6 touchdowns, continuing to show why he’s one of the NFL’s elite. His connection with tight end Travis Kelce remains crucial, though the team’s offense has been balanced by the emergence of running back Kareem Hunt, who has added over 170 rushing yards. Kansas City’s offense ranks 11th in total yards but will face a stiff challenge against a strong 49ers defense. San Francisco’s offense, orchestrated by Brock Purdy, has been one of the league’s most productive, averaging 429.5 yards per game. Purdy has passed for over 1,600 yards, with 9 touchdowns through six games. The 49ers’ ground game, led by Jordan Mason, who has racked up 609 rushing yards, has kept opposing defenses on their heels. Wide receiver Brandon Aiyuk has been Purdy’s primary target, with 351 receiving yards on the season. On defense, the Chiefs have been solid, allowing just 17 points per game, good for 6th in the league. Their ability to shut down opposing offenses, especially in the red zone, will be crucial as they look to contain San Francisco’s rushing attack. The 49ers, on the other hand, are strong against both the run and the pass, ranking in the top 10 in total defense. This matchup is expected to be closely contested, with both teams needing to execute on both sides of the ball to come out on top. The 49ers’ balanced attack and home-field advantage give them a slight edge, but the Chiefs, with Mahomes leading the way, are always a threat to pull off a victory.

Kansas City Chiefs NFL Preview

The Kansas City Chiefs, at 5-0, have once again looked like Super Bowl contenders. Patrick Mahomes is having another stellar season, throwing for over 1,200 yards and 6 touchdowns. Tight end Travis Kelce remains a key part of the offense, while the addition of Kareem Hunt in the backfield has added balance to Kansas City’s attack. On defense, the Chiefs have quietly been one of the league’s best units. They rank 7th in total defense and have been particularly effective at stopping the run, allowing just 88.4 rushing yards per game. The Chiefs’ pass rush, led by Chris Jones, will look to disrupt Brock Purdy and force turnovers, which could swing the game in Kansas City’s favor. In what promises to be a high-stakes battle, Kansas City will need to limit San Francisco’s ground game and continue their balanced offensive approach to remain unbeaten.

The Kansas City Chiefs, undefeated at 5-0, will face the San Francisco 49ers, currently 3-3, at Levi’s Stadium on October 20, 2024. The Chiefs, led by Patrick Mahomes, aim to stay perfect, while the 49ers, featuring Brock Purdy, seek to snap their recent skid in what could be a thrilling offensive showdown. Kansas City vs San Francisco AI Prediction: Free NFL Betting Insights for Oct 20. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Francisco 49ers NFL Preview

The San Francisco 49ers come into this Week 7 matchup with a 3-3 record, needing a win to regain momentum in the NFC West. Quarterback Brock Purdy has been efficient, passing for over 1,600 yards and 9 touchdowns. Purdy’s chemistry with wide receiver Brandon Aiyuk has been critical for San Francisco’s success in the passing game. The 49ers’ offense has relied heavily on their ground game, with Jordan Mason having a breakout season, rushing for 609 yards at a 5.34 yards-per-carry clip. Defensively, the 49ers have been stout, particularly against the run, allowing just 101 rushing yards per game. Led by linebacker Fred Warner and defensive end Nick Bosa, San Francisco’s defense has the ability to make game-changing plays. If the defense can pressure Mahomes and force Kansas City into third-and-long situations, they can keep the game within reach.

Kansas City vs. San Francisco Prop Picks (AI)

Remi is pouring through loads of datapoints on each line. In fact, anytime the Chiefs and 49ers play there’s always several intriguing trends to key in on. Not to mention games played at Levi's Stadium in Oct can often follow normal, predictable patterns.
Remi searched hard and found the best prop bet prediction for this matchup: George Kittle Over 48.5 Total Receiving Yards

Kansas City vs. San Francisco Prediction (AI)

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Remi, our AI sports genius, has been pouring over millions of data from every angle between the Chiefs and 49ers and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.

The Algorithm has been most keyed in on the linear correlation of emphasis knucklehead sportsbettors often put on coaching factors between a Chiefs team going up against a possibly strong 49ers team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Kansas City vs San Francisco picks, computer picks Chiefs vs 49ers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NFL 10/20 HOU@SEA UNLOCK THIS PICK 5 INTEL Locked INTEL
NFL 10/20 TB@DET UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/20 TB@DET UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/20 TB@DET UNLOCK THIS PICK 1 INTEL Locked INTEL
NFL 10/20 HOU@SEA UNLOCK THIS PICK 0 INTEL Locked INTEL
NFL 10/20 TB@DET UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Chiefs Betting Trends

The Chiefs have been strong against the spread (ATS), covering in 7 of their last 10 games. Their high-powered offense and Mahomes’ playmaking ability make them a solid bet, even when favored on the road.

49ers Betting Trends

The 49ers have been slightly better ATS at home, covering 6 times in their last 10 games. Their dominant rushing attack, led by Jordan Mason, has helped control games at Levi’s Stadium .

Chiefs vs. 49ers Matchup Trends

The over/under is set at 47.5 points. Both teams boast top offenses—San Francisco ranks 3rd in total offense while Kansas City sits at 11th. Given both teams’ explosive playmakers, the over has hit in several recent matchups involving these squads.

Kansas City vs. San Francisco Game Info

Kansas City vs San Francisco starts on October 20, 2024 at 4:25 PM EST.

Spread: San Francisco -1.5
Moneyline: Kansas City +101, San Francisco -121
Over/Under: 47

Kansas City:  |  San Francisco:

Remi searched hard and found the best prop bet prediction for this matchup: George Kittle Over 48.5 Total Receiving Yards . Prices move—always shop for the best number.

The over/under is set at 47.5 points. Both teams boast top offenses—San Francisco ranks 3rd in total offense while Kansas City sits at 11th. Given both teams’ explosive playmakers, the over has hit in several recent matchups involving these squads.

KC trend: The Chiefs have been strong against the spread (ATS), covering in 7 of their last 10 games. Their high-powered offense and Mahomes’ playmaking ability make them a solid bet, even when favored on the road.

SF trend: The 49ers have been slightly better ATS at home, covering 6 times in their last 10 games. Their dominant rushing attack, led by Jordan Mason, has helped control games at Levi’s Stadium .

See our latest NFL picks and odds pages for 2024 to compare prices before you bet.

Kansas City vs. San Francisco Odds

Remi is pouring through mountains of data points on each line. In fact, anytime the Kansas City vs San Francisco trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable patterns.

Kansas City vs San Francisco Opening Odds

KC Moneyline: +101
SF Moneyline: -121
KC Spread: +1.5
SF Spread: -1.5
Over/Under: 47

Kansas City vs San Francisco Live Odds

Games PTS ML SPR O/U
Oct 23, 2025 8:15PM EDT
Minnesota Vikings
Los Angeles Chargers
10/23/25 8:15PM
Vikings
Chargers
+133
-167
+3 (-114)
-3 (-112)
O 44.5 (-113)
U 44.5 (-113)
Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
+265
-375
+7 (-118)
-7 (-108)
O 40.5 (-109)
U 40.5 (-117)
Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
-500
+340
-7.5 (-115)
+7.5 (-110)
O 46.5 (-112)
U 46.5 (-113)
Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
+235
-315
+6.5 (-112)
-6.5 (-114)
O 44 (-109)
U 44 (-115)
Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
+260
-360
+6.5 (-110)
-6.5 (-115)
O 50 (-115)
U 50 (-109)
Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
+275
-385
+7 (-113)
-7 (-113)
O 43 (-114)
U 43 (-112)
Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
-109
-117
+1 (-115)
-1 (-109)
O 41 (-115)
U 41 (-110)
Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
+295
-420
+7 (-108)
-7 (-118)
O 44.5 (-113)
U 44.5 (-113)
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
-245
+185
-4.5 (-115)
+4.5 (-110)
O 47.5 (-109)
U 47.5 (-117)
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
+135
-175
+3.5 (-118)
-3.5 (-108)
O 50 (-109)
U 50 (-117)
Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
+650
-1250
+14 (-108)
-14 (-118)
O 47 (-113)
U 47 (-113)
Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
-177
+135
-3 (-113)
+3 (-113)
O 45 (-112)
U 45 (-113)
Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
+420
-670
+10.5 (-114)
-10.5 (-112)
O 48 (-113)
U 48 (-113)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Kansas City Chiefs vs. San Francisco 49ers on October 20, 2024 at Levi's Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS
HOU@BAL HOU -125 58.5% 7 WIN
DET@CIN DET -10 55.6% 5 WIN
DAL@NYJ NYJ +1.5 53.7% 3 LOSS
TB@SEA TB +3.5 54.9% 4 WIN
TEN@ARI ARI -7 (BUY 0.5) 54.9% 4 LOSS
DEN@PHI DEN +4.5 57.5% 7 WIN
MIA@CAR TETAIROA MCMILLAN OVER 58.5 RECV YDS 54.5% 4 WIN
LV@IND ASHTON JEANTY UNDER 67.5 RUSH YDS 54.4% 4 WIN
SF@LAR DEMARCUS ROBINSON OVER 29.5 RECV YDS 55.7% 5 WIN
NYJ@MIA NYJ +3 53.8 3 LOSS
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS
TEN@HOU TEN +7.5 57.9% 7 LOSS
LAC@NYG LAC -6 57.3% 7 LOSS
NO@BUF UNDER 48.5 55.1% 3 LOSS
GB@DAL JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS 55.5% 5 LOSS
CAR@NE DRAKE MAYE TO THROW AN INT 56.6% 6 LOSS
SEA@ARI SEA -125 57.7% 6 WIN
SEA@ARI KYLER MURRAY TO THROW AN INT 56.6% 6 WIN
DET@BAL JAHMYR GIBBS OVER 0.5 RUSH TDS 55.8% 5 WIN
DAL@CHI DAL -120 58.7% 6 LOSS
PIT@NE PIT -116 60.1% 6 WIN
ATL@CAR ATL -4.5 55.4% 5 LOSS
LV@WAS LV +3 54.3% 4 LOSS