49ers vs. Seahawks
Prediction, Odds & Props
Oct 10 | NFL AI Picks
Updated: 2024-10-03T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The San Francisco 49ers (2-3) will face the Seattle Seahawks (3-2) on October 10, 2024, at Lumen Field. The game pits the top two NFC West teams against each other, and both are looking to regain momentum after recent losses. This divisional clash is critical, as a victory would solidify Seattle’s lead in the division or help the 49ers gain ground.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Oct 10, 2024
Start Time: 8:15 PM EST
Venue: Lumen Field
Seahawks Record: (2-1)
49ers Record: (0-2)
OPENING ODDS
SF Moneyline: -181
SEA Moneyline: +151
SF Spread: -3.5
SEA Spread: +3.5
Over/Under: 47.5
SF
Betting Trends
- The 49ers have struggled against the spread (ATS) recently, going 1-3-1 overall this season and 0-1-1 ATS in their away games. They have covered the spread only twice in their last nine games.
SEA
Betting Trends
- The Seahawks are 2-1 ATS at home this season but 1-5-1 ATS in their last seven games overall. Despite a strong home-field advantage historically, they’ve struggled to cover the spread consistently.
MATCHUP TRENDS
- The 49ers have dominated this matchup recently, covering the spread in four of the last five meetings against Seattle. However, Seattle is 10-3 straight up in their last 13 home games against San Francisco, making this a tricky game to predict.
SF vs. SEA
Best Prop Bet
- Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.
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San Francisco vs Seattle Prediction & Odds:
Free NFL Betting Insights for 10/10/24
Seattle’s pass rush, led by Derick Hall, needs to step up against a 49ers offensive line that has been vulnerable at times. Geno Smith has been solid under center, throwing for 1,466 yards and five touchdowns, but Seattle’s ground game has been lackluster, ranking near the bottom of the league in rushing yards per game. Both teams need to tighten up defensively to have a chance in this contest. San Francisco’s defense ranks 12th in the league, giving up 21.2 points per game, while Seattle has been less effective, allowing 22.8 points per game. The key to victory will likely come down to which defense can step up and make crucial stops. Given the Seahawks’ strong historical performance at home and San Francisco’s recent struggles in Seattle, this game could go either way.
Brock Purdy became the fastest 49ers QB to 50 passing TDs.
— San Francisco 49ers (@49ers) October 7, 2024
Check out his top plays from Week 5 👇 pic.twitter.com/meFloAz1Xd
San Francisco 49ers NFL Preview
The San Francisco 49ers head into this game with a 2-3 record, needing a win to avoid falling further behind in the NFC West. After a heartbreaking 24-23 loss to the Arizona Cardinals last week, in which they squandered a 13-point lead, the 49ers need to find answers quickly. With Christian McCaffrey still sidelined, the focus will be on Brock Purdy and Jordan Mason to generate offensive production. The 49ers have had a solid offensive showing overall, averaging 25.2 points per game, but turnovers and poor red-zone efficiency have been major issues. Purdy, while talented, needs to be more careful with the ball. Defensively, San Francisco has been better, allowing only 21.2 points per game. Fred Warner and the front seven will be tasked with keeping Geno Smith under control and limiting Seattle’s deep passing game. The absence of McCaffrey has shifted the offensive dynamics, putting more pressure on the passing game. Players like Brandon Aiyuk and Jauan Jennings must step up to fill the void left by their star running back. If the 49ers’ defense can force Smith into turnovers and their offense can establish some balance, San Francisco should have a good shot at victory despite their underdog status.
Credit: USA TODAY/IMAGN
Seattle Seahawks NFL Preview
The Seattle Seahawks are facing a pivotal moment in their season as they prepare to host the 49ers. Coming off back-to-back losses, including a disappointing 29-20 defeat to the New York Giants, the Seahawks must find a way to shore up their defensive lapses. Despite their recent struggles, they still hold a 3-2 record and lead the NFC West. Seattle’s defense has been porous, allowing 71 points in their last two games and struggling against both the pass and run. This inconsistency has prevented them from closing out games, despite Geno Smith’s solid performances. Smith has thrown for 1,466 yards and five touchdowns, and he remains a dual threat with his ability to scramble when needed. Wide receivers DK Metcalf and Tyler Lockett will be key in stretching the 49ers’ secondary, but Seattle needs to establish a more consistent ground game. The defense, led by Hall and linebacker Tyrel Dodson, must find a way to create pressure on Purdy and force the 49ers into mistakes. Given Seattle’s strong record at Lumen Field against San Francisco, the home crowd could be a crucial factor. If they can prevent big plays and limit the 49ers’ rushing attack, Seattle has a chance to stay atop the division.
A record-breaking return. #GoHawks x @Novavax pic.twitter.com/v81g15Mcno
— Seattle Seahawks (@Seahawks) October 7, 2024
San Francisco vs. Seattle Prop Picks (AI)
San Francisco vs. Seattle Prediction (AI)
Remi, our AI sports wizard, has been pouring over tons of data from every simulation between the 49ers and Seahawks and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most focused on the growing emphasis human bettors tend to put on San Francisco’s strength factors between a 49ers team going up against a possibly unhealthy Seahawks team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI San Francisco vs Seattle picks, computer picks 49ers vs Seahawks, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
49ers Betting Trends
The 49ers have struggled against the spread (ATS) recently, going 1-3-1 overall this season and 0-1-1 ATS in their away games. They have covered the spread only twice in their last nine games.
Seahawks Betting Trends
The Seahawks are 2-1 ATS at home this season but 1-5-1 ATS in their last seven games overall. Despite a strong home-field advantage historically, they’ve struggled to cover the spread consistently.
49ers vs. Seahawks Matchup Trends
The 49ers have dominated this matchup recently, covering the spread in four of the last five meetings against Seattle. However, Seattle is 10-3 straight up in their last 13 home games against San Francisco, making this a tricky game to predict.
San Francisco vs. Seattle Game Info
What time does San Francisco vs Seattle start on October 10, 2024?
San Francisco vs Seattle starts on October 10, 2024 at 8:15 PM EST.
Where is San Francisco vs Seattle being played?
Venue: Lumen Field.
What are the opening odds for San Francisco vs Seattle?
Spread: Seattle +3.5
Moneyline: San Francisco -181, Seattle +151
Over/Under: 47.5
What are the records for San Francisco vs Seattle?
San Francisco: (0-2) | Seattle: (2-1)
What is the AI best bet for San Francisco vs Seattle?
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.
What are San Francisco vs Seattle trending bets?
The 49ers have dominated this matchup recently, covering the spread in four of the last five meetings against Seattle. However, Seattle is 10-3 straight up in their last 13 home games against San Francisco, making this a tricky game to predict.
What are San Francisco trending bets?
SF trend: The 49ers have struggled against the spread (ATS) recently, going 1-3-1 overall this season and 0-1-1 ATS in their away games. They have covered the spread only twice in their last nine games.
What are Seattle trending bets?
SEA trend: The Seahawks are 2-1 ATS at home this season but 1-5-1 ATS in their last seven games overall. Despite a strong home-field advantage historically, they’ve struggled to cover the spread consistently.
Where can I find AI Picks for San Francisco vs Seattle?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
San Francisco vs. Seattle Odds
AI algorithm Remi is pouring through tons of stats on each player. In fact, anytime the San Francisco vs Seattle trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable betting trends.
San Francisco vs Seattle Opening Odds
SF Moneyline:
-181 SEA Moneyline: +151
SF Spread: -3.5
SEA Spread: +3.5
Over/Under: 47.5
San Francisco vs Seattle Live Odds
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|---|---|---|---|---|---|
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Sep 28, 2025 8:31AM EDT
Minnesota Vikings
Pittsburgh Steelers
9/28/25 8:31AM
Vikings
Steelers
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–
–
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-142
+120
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-2.5 (-112)
+2.5 (-108)
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O 40.5 (-112)
U 40.5 (-108)
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Sep 28, 2025 12:01PM EDT
Tennessee Titans
Houston Texans
9/28/25 12:01PM
Titans
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–
–
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+310
-390
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+7.5 (-122)
-7.5 (+100)
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O 38.5 (-118)
U 38.5 (-104)
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Sep 28, 2025 12:01PM EDT
Philadelphia Eagles
Tampa Bay Buccaneers
9/28/25 12:01PM
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-188
+158
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-3.5 (-105)
+3.5 (-115)
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O 44.5 (-102)
U 44.5 (-120)
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Washington Commanders
Atlanta Falcons
9/28/25 12:01PM
Commanders
Falcons
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–
–
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+106
-124
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+2.5 (-120)
-2.5 (-102)
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O 43.5 (-110)
U 43.5 (-110)
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Sep 28, 2025 12:01PM EDT
New Orleans Saints
Buffalo Bills
9/28/25 12:01PM
Saints
Bills
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–
–
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+870
-1500
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+14.5 (-105)
-14.5 (-115)
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O 48.5 (-104)
U 48.5 (-118)
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Sep 28, 2025 12:01PM EDT
Carolina Panthers
New England Patriots
9/28/25 12:01PM
Panthers
Patriots
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–
–
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+198
-240
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+5.5 (-110)
-5.5 (-110)
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O 43.5 (-105)
U 43.5 (-115)
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Sep 28, 2025 1:00PM EDT
Cleveland Browns
Detroit Lions
9/28/25 1PM
Browns
Lions
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–
–
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+430
-590
|
+9.5 (-102)
-9.5 (-120)
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O 44.5 (-110)
U 44.5 (-110)
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Sep 28, 2025 1:00PM EDT
Los Angeles Chargers
New York Giants
9/28/25 1PM
Chargers
Giants
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–
–
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-290
+235
|
-6.5 (-106)
+6.5 (-114)
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O 43.5 (-110)
U 43.5 (-110)
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Sep 28, 2025 3:06PM EDT
Jacksonville Jaguars
San Francisco 49ers
9/28/25 3:06PM
Jaguars
49ers
|
–
–
|
+148
-176
|
+3.5 (-120)
-3.5 (-102)
|
O 46.5 (-110)
U 46.5 (-110)
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Sep 28, 2025 3:06PM EDT
Indianapolis Colts
Los Angeles Rams
9/28/25 3:06PM
Colts
Rams
|
–
–
|
+156
-186
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+3.5 (-115)
-3.5 (-105)
|
O 49.5 (-112)
U 49.5 (-108)
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Sep 28, 2025 3:26PM EDT
Chicago Bears
Las Vegas Raiders
9/28/25 3:26PM
Bears
Raiders
|
–
–
|
+108
-126
|
+1.5 (-105)
-1.5 (-115)
|
O 47.5 (-115)
U 47.5 (-105)
|
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Sep 28, 2025 4:25PM EDT
Baltimore Ravens
Kansas City Chiefs
9/28/25 4:25PM
Ravens
Chiefs
|
–
–
|
-144
+122
|
-2.5 (-118)
+2.5 (-104)
|
O 48.5 (-115)
U 48.5 (-105)
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Sep 28, 2025 7:21PM EDT
Green Bay Packers
Dallas Cowboys
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Packers
Cowboys
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–
–
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-320
+260
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-6.5 (-115)
+6.5 (-105)
|
O 46.5 (-110)
U 46.5 (-110)
|
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Sep 29, 2025 7:15PM EDT
New York Jets
Miami Dolphins
9/29/25 7:15PM
Jets
Dolphins
|
–
–
|
+132
-156
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+2.5 (-102)
-2.5 (-120)
|
O 44.5 (-108)
U 44.5 (-112)
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Sep 29, 2025 8:15PM EDT
Cincinnati Bengals
Denver Broncos
9/29/25 8:15PM
Bengals
Broncos
|
–
–
|
+340
-430
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+7.5 (-108)
-7.5 (-112)
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O 43.5 (-115)
U 43.5 (-105)
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Oct 2, 2025 7:16PM EDT
San Francisco 49ers
Los Angeles Rams
10/2/25 7:16PM
49ers
Rams
|
–
–
|
+134
-158
|
+3 (-110)
-3 (-110)
|
O 47.5 (-105)
U 47.5 (-115)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Francisco 49ers vs. Seattle Seahawks on October 10, 2024 at Lumen Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |
| GB@CLE | GB -7 | 54.3% | 4 | LOSS |
| ARI@SF | ARI +3 | 57.7% | 6 | WIN |
| KC@NYG | PATRICK MAHOMES OVER 230.5 PASS YDS | 54.7% | 4 | WIN |
| GB@CLE | JOE FLACCO OVER 37.5 PASS ATT | 56.6% | 6 | LOSS |
| MIA@BUF | TYREEK HILL OVER 5.5 TOTAL RECEPTIONS | 56.8% | 6 | LOSS |
| LAC@LV | LAC -3 | 54.9% | 4 | WIN |
| TB@HOU | BAKER MAYFIELD OVER 1.5 PASS TDS | 54.4% | 4 | WIN |
| CHI@DET | DET -6.5 | 54.3% | 4 | WIN |
| DEN@IND | DEN -118 | 60.1% | 10 | LOSS |
| PHI@KC | PHI -115 | 56.7% | 6 | WIN |
| SF@NO | SF -3 | 58.8% | 8 | WIN |
| SEA@PIT | OVER 40 | 54.9% | 4 | WIN |
| CAR@ARI | BRYCE YOUNG INTERCEPTIONS UNDER 0.5 | 56.4% | 6 | LOSS |
| DEN@IND | JOSH DOWNS RECEPTIONS OVER 3.5 | 54.7% | 4 | WIN |
| ATL@MIN | BIJAN ROBINSON RUSH + REC YDS OVER 94.5 | 53.4% | 3 | WIN |
| WAS@GB | WAS +3.5 | 56.5% | 6 | LOSS |
| WAS@GB | JORDAN LOVE OVER 5.5 RUSH YDS | 54.7% | 4 | WIN |
| MIN@CHI | CALEB WILLIAMS OVER 219.5 PASS YDS | 53.4% | 3 | LOSS |
| TEN@DEN | DEN -8.5 | 55.3% | 5 | LOSS |
| SF@SEA | SF -115 | 54.6% | 4 | WIN |
| SF@SEA | KENNETH WALKER III UNDER 79.5 RUSH+REC YDS | 54.6% | 4 | WIN |
| CAR@JAC | TANK BIGSBY OVER 10.5 RUSH ATT | 56.1% | 6 | LOSS |
| KC@LAC | JUSTIN HERBERT UNDER 0.5 INT | 54.1% | 3 | WIN |
| DAL@PHI | GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS | 54.1% | 4 | LOSS |
| KC@PHI | JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS | 53.90% | 5 | WIN |
| KC@PHI | DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS | 54.40% | 6 | WIN |
| KC@PHI | PATRICK MAHOMES UNDER 68.3% PASS COMP | 55.00% | 8 | WIN |
| KC@PHI | JALEN HURTS LONGEST RUSH OVER 12.5 YDS | 55.60% | 8 | WIN |
| BUF@KC | DALTON KINCAID OVER 29.5 RECV YDS | 55.10% | 8 | LOSS |
| WAS@PHI | DEVONTA SMITH OVER 3.5 RECEPTIONS | 55.80% | 8 | WIN |
| BUF@KC | JAMES COOK ANYTIME TD | 53.00% | 5 | WIN |
| LAR@PHI | SAQUON BARKLEY UNDER 128 RUSH + REC YDS | 53.20% | 5 | LOSS |
| BAL@BUF | LAMAR JACKSON OVER 54.5 RUSH YDS | 54.50% | 6 | LOSS |
| HOU@KC | C.J. STROUD RUSH YDS UNDER 14.5 | 53.10% | 5 | LOSS |
| WAS@DET | JAMESON WILLIAMS RUSH YDS OVER 1.5 | 53.30% | 5 | WIN |
| WAS@DET | JARED GOFF PASS COMP % UNDER 72.3 | 54.30% | 6 | WIN |
| MIN@LAR | COOPER KUPP ANYTIME TOUCHDOWN | 52.60% | 3 | LOSS |
| MIN@LAR | MATTHEW STAFFORD OVER 21.5 PASS COMP | 54.10% | 6 | LOSS |
| WAS@TB | BRIAN ROBINSON JR OVER 1.5 REC TARGETS | 53.50% | 5 | WIN |
| WAS@TB | BAKER MAYFIELD UNDER 33.5 PASS ATT | 54.90% | 6 | WIN |
| GB@PHI | JALEN HURTS OVER 67.1 PASS COMP PERCENTAGE | 54.60% | 6 | LOSS |
| LAC@HOU | J.K. DOBBINS ANYTIME TD | 52.80% | 3 | LOSS |
| LAC@HOU | LAC -2.5 | 53.40% | 3 | LOSS |
| LAC@HOU | JUSTIN HERBERT OVER 19.5 RUSH YDS | 53.40% | 5 | LOSS |