Cardinals vs. 49ers
Prediction, Odds & Props
Oct 06 | NFL AI Picks
Updated: 2024-09-29T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Arizona Cardinals (1-3) will face the San Francisco 49ers (2-2) on October 6, 2024, at Levi’s Stadium. The 49ers are coming off a dominant win over the New England Patriots, while the Cardinals are looking to rebound after a disappointing loss to the Washington Commanders.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Oct 06, 2024
Start Time: 4:05 PM EST
Venue: Levi's Stadium
49ers Record: (2-2)
Cardinals Record: (1-3)
OPENING ODDS
ARI Moneyline: +281
SF Moneyline: -355
ARI Spread: +7.5
SF Spread: -7.5
Over/Under: 50.5
ARI
Betting Trends
- The Cardinals have a 3-1 ATS (Against the Spread) record this season. Their strong ATS performance has been due to effective rushing and limiting turnovers, even when their overall win-loss record has struggled.
SF
Betting Trends
- The 49ers are 1-3 ATS this season. Despite their strong statistical performance in yardage and points per game, the 49ers have struggled to cover spreads due to inconsistent offensive production and lapses in critical moments.
MATCHUP TRENDS
- The Cardinals have been effective at covering the spread in division matchups, and they have managed to cover in four of their last six road games against the 49ers. Meanwhile, San Francisco has covered in only two of their last five home games when favored by more than a touchdown.
ARI vs. SF
Best Prop Bet
- Remi's searched hard and found a NFL AI prop bet for this matchup: Trey McBride Anytime TD
LIVE NFL ODDS
NFL ODDS COMPARISON
WANT MORE AI PICKS?
NET UNITS (INCL VIG)
NET PROFIT (INCL VIG) $100/UNIT
NET UNITS (INCL VIG)
NET PROFIT (INCL VIG) $100/UNIT
AI SPORTS PICK PRODUCTS
Create a Free Account
‘Create an Account’ to Get Remi’s Picks Today. Remi Finds New Picks
Remi calculates the probability a team will cover the line. Remi Works 24/7
Remi uses this probability to assign units to each pick.
Get Remi's AI Picks
Get Remi’s Top AI Sports Picks sent direct to your inbox.
Hedge Meaning in Betting | 4 Obvious Times to Hedge
Learn about hedge betting to manage risk and secure profits. Understand...
What is a Push in Betting? | 3 Ways To Use To Your Advantage
Understand what a push in betting means, how it happens in...
What Does the + and – Mean in Sports Betting? | 5 Easy Tips
Learn the basics of sports betting odds, what the plus (+)...
Arizona vs San Francisco Prediction & Odds:
Free NFL Betting Insights for 10/6/24
The rushing attack, led by James Conner with 293 rushing yards, has been a bright spot for Arizona. However, defensive issues have plagued the Cardinals, as they’ve allowed 26.5 points per game and struggled to stop the run. The key to this matchup will be how Arizona’s run defense handles the 49ers’ potent ground game, which is averaging 141.8 rushing yards per game. If San Francisco can control the line of scrimmage, it could be a long day for the Cardinals. On the flip side, Arizona will need to establish their run game early and keep San Francisco’s high-powered offense off the field.
No. 6 pic.twitter.com/L3SDYXvd30
— Arizona Cardinals (@AZCardinals) September 30, 2024
Arizona Cardinals NFL Preview
The Arizona Cardinals are in a rebuilding phase under head coach Jonathan Gannon, and their 1-3 start reflects the challenges they face. Kyler Murray has been efficient, completing 75 of 108 passes for 777 yards and 6 touchdowns. James Conner has been the focal point of the ground game, averaging 4.58 yards per carry and scoring 3 touchdowns. However, the team has struggled to generate explosive plays, ranking near the bottom of the league in passing yards per game. Defensively, the Cardinals have been porous, allowing 26.5 points per game and ranking 28th in rushing defense with 146.5 yards allowed per contest. The key for Arizona will be to tighten up their run defense and put pressure on Brock Purdy to force mistakes. If they can get off the field on third downs and avoid giving up big plays, they may be able to keep the game within reach. To have a chance against San Francisco, the Cardinals will need a near-perfect game from Murray and a strong performance from their offensive line to control the tempo. If they fall behind early, it will be tough for them to catch up against a 49ers defense that excels at playing with a lead
Credit: USA TODAY/IMAGN
San Francisco 49ers NFL Preview
The San Francisco 49ers enter this game looking to gain momentum and improve on their 2-2 record. Brock Purdy has been efficient, completing 84 of 122 passes for 1,130 yards and 5 touchdowns. His primary weapons, Jauan Jennings and Brandon Aiyuk, have combined for over 500 receiving yards. The 49ers’ rushing attack, led by Jordan Mason’s 447 yards, has been the backbone of their offensive strategy. Defensively, the 49ers are allowing just 20.5 points per game, ranking among the top in the league. Their pass rush, led by Kevin Givens, has been dominant, recording 4 sacks this season. The 49ers’ run defense has been even more impressive, allowing just 96.3 rushing yards per game. The team will look to stifle Arizona’s rushing attack and force Kyler Murray into difficult passing situations. If the 49ers can minimize turnovers and continue to capitalize on short-field opportunities, they should be able to control the game and secure a victory at home
Back on the winning side 🙌
— San Francisco 49ers (@49ers) October 2, 2024
Sights and sounds from Week 4 #NEvsSF. pic.twitter.com/EmBsXtLgFY
Arizona vs. San Francisco Prop Picks (AI)
Arizona vs. San Francisco Prediction (AI)
Remi, our AI sports genius, has been pouring over millions of data from every simulation between the Cardinals and 49ers and using recursive machine learning and impressive AI to analyze the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most fixated on the unproportionally assigned factor human bettors tend to put on player performance factors between a Cardinals team going up against a possibly unhealthy 49ers team. We’ve found the true game analytics might reflect a strong lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Arizona vs San Francisco picks, computer picks Cardinals vs 49ers, best bets, model edges, confidence ratings.
 |
DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Cardinals Betting Trends
The Cardinals have a 3-1 ATS (Against the Spread) record this season. Their strong ATS performance has been due to effective rushing and limiting turnovers, even when their overall win-loss record has struggled.
49ers Betting Trends
The 49ers are 1-3 ATS this season. Despite their strong statistical performance in yardage and points per game, the 49ers have struggled to cover spreads due to inconsistent offensive production and lapses in critical moments.
Cardinals vs. 49ers Matchup Trends
The Cardinals have been effective at covering the spread in division matchups, and they have managed to cover in four of their last six road games against the 49ers. Meanwhile, San Francisco has covered in only two of their last five home games when favored by more than a touchdown.
Arizona vs. San Francisco Game Info
What time does Arizona vs San Francisco start on October 06, 2024?
Arizona vs San Francisco starts on October 06, 2024 at 4:05 PM EST.
Where is Arizona vs San Francisco being played?
Venue: Levi's Stadium.
What are the opening odds for Arizona vs San Francisco?
Spread: San Francisco -7.5
Moneyline: Arizona +281, San Francisco -355
Over/Under: 50.5
What are the records for Arizona vs San Francisco?
Arizona: (1-3) | San Francisco: (2-2)
What is the AI best bet for Arizona vs San Francisco?
Remi's searched hard and found a NFL AI prop bet for this matchup: Trey McBride Anytime TD. Prices move—always shop for the best number.
What are Arizona vs San Francisco trending bets?
The Cardinals have been effective at covering the spread in division matchups, and they have managed to cover in four of their last six road games against the 49ers. Meanwhile, San Francisco has covered in only two of their last five home games when favored by more than a touchdown.
What are Arizona trending bets?
ARI trend: The Cardinals have a 3-1 ATS (Against the Spread) record this season. Their strong ATS performance has been due to effective rushing and limiting turnovers, even when their overall win-loss record has struggled.
What are San Francisco trending bets?
SF trend: The 49ers are 1-3 ATS this season. Despite their strong statistical performance in yardage and points per game, the 49ers have struggled to cover spreads due to inconsistent offensive production and lapses in critical moments.
Where can I find AI Picks for Arizona vs San Francisco?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
Arizona vs. San Francisco Odds
Remi is pouring through mountains of data on each team. In fact, anytime the Arizona vs San Francisco trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude almost always follow normal, predictable patterns.
Arizona vs San Francisco Opening Odds
ARI Moneyline:
+281 SF Moneyline: -355
ARI Spread: +7.5
SF Spread: -7.5
Over/Under: 50.5
Arizona vs San Francisco Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Sep 28, 2025 9:31AM EDT
Minnesota Vikings
Pittsburgh Steelers
9/28/25 9:31AM
Vikings
Steelers
|
–
–
|
-140
+115
|
-2.5 (-115)
+2.5 (-105)
|
O 41 (-110)
U 41 (-110)
|
|
|
Sep 28, 2025 1:00PM EDT
Cleveland Browns
Detroit Lions
9/28/25 1PM
Browns
Lions
|
–
–
|
+400
-550
|
+10 (-110)
-10 (-110)
|
O 44.5 (-105)
U 44.5 (-115)
|
|
|
Sep 28, 2025 1:00PM EDT
Los Angeles Chargers
New York Giants
9/28/25 1PM
Chargers
Giants
|
–
–
|
-285
+230
|
-6.5 (-105)
+6.5 (-115)
|
O 44 (-110)
U 44 (-110)
|
|
|
Sep 28, 2025 1:01PM EDT
Tennessee Titans
Houston Texans
9/28/25 1:01PM
Titans
Texans
|
–
–
|
+300
-375
|
+7 (-105)
-7 (-115)
|
O 39 (-110)
U 39 (-110)
|
|
|
Sep 28, 2025 1:01PM EDT
Philadelphia Eagles
Tampa Bay Buccaneers
9/28/25 1:01PM
Eagles
Buccaneers
|
–
–
|
-190
+160
|
-3.5 (-105)
+3.5 (-115)
|
O 44 (-110)
U 44 (-110)
|
|
|
Sep 28, 2025 1:01PM EDT
Washington Commanders
Atlanta Falcons
9/28/25 1:01PM
Commanders
Falcons
|
–
–
|
+110
-130
|
+2 (-110)
-2 (-110)
|
O 43.5 (-110)
U 43.5 (-110)
|
|
|
Sep 28, 2025 1:01PM EDT
New Orleans Saints
Buffalo Bills
9/28/25 1:01PM
Saints
Bills
|
–
–
|
+800
-1300
|
+15 (-110)
-15 (-110)
|
O 48 (-110)
U 48 (-110)
|
|
|
Sep 28, 2025 1:01PM EDT
Carolina Panthers
New England Patriots
9/28/25 1:01PM
Panthers
Patriots
|
–
–
|
+200
-250
|
+5.5 (-110)
-5.5 (-110)
|
O 43 (-110)
U 43 (-110)
|
|
|
Sep 28, 2025 4:06PM EDT
Jacksonville Jaguars
San Francisco 49ers
9/28/25 4:06PM
Jaguars
49ers
|
–
–
|
+150
-180
|
+3.5 (-115)
-3.5 (-105)
|
O 46.5 (-110)
U 46.5 (-110)
|
|
|
Sep 28, 2025 4:06PM EDT
Indianapolis Colts
Los Angeles Rams
9/28/25 4:06PM
Colts
Rams
|
–
–
|
+160
-190
|
+3.5 (-110)
-3.5 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
|
Sep 28, 2025 4:25PM EDT
Baltimore Ravens
Kansas City Chiefs
9/28/25 4:25PM
Ravens
Chiefs
|
–
–
|
-150
+125
|
-2.5 (-120)
+2.5 (+100)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
|
Sep 28, 2025 4:26PM EDT
Chicago Bears
Las Vegas Raiders
9/28/25 4:26PM
Bears
Raiders
|
–
–
|
+100
-120
|
+1 (-110)
-1 (-110)
|
O 48 (-110)
U 48 (-110)
|
|
|
Sep 28, 2025 8:21PM EDT
Green Bay Packers
Dallas Cowboys
9/28/25 8:21PM
Packers
Cowboys
|
–
–
|
-325
+250
|
-7 (-105)
+7 (-115)
|
O 47 (-110)
U 47 (-110)
|
|
|
Sep 29, 2025 7:15PM EDT
New York Jets
Miami Dolphins
9/29/25 7:15PM
Jets
Dolphins
|
–
–
|
+125
-150
|
+3 (-115)
-3 (-105)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Sep 29, 2025 8:15PM EDT
Cincinnati Bengals
Denver Broncos
9/29/25 8:15PM
Bengals
Broncos
|
–
–
|
+310
-400
|
+7.5 (-110)
-7.5 (-110)
|
O 44 (-110)
U 44 (-110)
|
|
|
Oct 2, 2025 8:16PM EDT
San Francisco 49ers
Los Angeles Rams
10/2/25 8:16PM
49ers
Rams
|
–
–
|
+134
-158
|
+3 (-105)
-3 (-115)
|
O 47 (-110)
U 47 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Arizona Cardinals vs. San Francisco 49ers on October 06, 2024 at Levi's Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |
| GB@CLE | GB -7 | 54.3% | 4 | LOSS |
| ARI@SF | ARI +3 | 57.7% | 6 | WIN |
| KC@NYG | PATRICK MAHOMES OVER 230.5 PASS YDS | 54.7% | 4 | WIN |
| GB@CLE | JOE FLACCO OVER 37.5 PASS ATT | 56.6% | 6 | LOSS |
| MIA@BUF | TYREEK HILL OVER 5.5 TOTAL RECEPTIONS | 56.8% | 6 | LOSS |
| LAC@LV | LAC -3 | 54.9% | 4 | WIN |
| TB@HOU | BAKER MAYFIELD OVER 1.5 PASS TDS | 54.4% | 4 | WIN |
| CHI@DET | DET -6.5 | 54.3% | 4 | WIN |
| DEN@IND | DEN -118 | 60.1% | 10 | LOSS |
| PHI@KC | PHI -115 | 56.7% | 6 | WIN |
| SF@NO | SF -3 | 58.8% | 8 | WIN |
| SEA@PIT | OVER 40 | 54.9% | 4 | WIN |
| CAR@ARI | BRYCE YOUNG INTERCEPTIONS UNDER 0.5 | 56.4% | 6 | LOSS |
| DEN@IND | JOSH DOWNS RECEPTIONS OVER 3.5 | 54.7% | 4 | WIN |
| ATL@MIN | BIJAN ROBINSON RUSH + REC YDS OVER 94.5 | 53.4% | 3 | WIN |
| WAS@GB | WAS +3.5 | 56.5% | 6 | LOSS |
| WAS@GB | JORDAN LOVE OVER 5.5 RUSH YDS | 54.7% | 4 | WIN |
| MIN@CHI | CALEB WILLIAMS OVER 219.5 PASS YDS | 53.4% | 3 | LOSS |
| TEN@DEN | DEN -8.5 | 55.3% | 5 | LOSS |
| SF@SEA | SF -115 | 54.6% | 4 | WIN |
| SF@SEA | KENNETH WALKER III UNDER 79.5 RUSH+REC YDS | 54.6% | 4 | WIN |
| CAR@JAC | TANK BIGSBY OVER 10.5 RUSH ATT | 56.1% | 6 | LOSS |
| KC@LAC | JUSTIN HERBERT UNDER 0.5 INT | 54.1% | 3 | WIN |
| DAL@PHI | GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS | 54.1% | 4 | LOSS |
| KC@PHI | JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS | 53.90% | 5 | WIN |
| KC@PHI | DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS | 54.40% | 6 | WIN |
| KC@PHI | PATRICK MAHOMES UNDER 68.3% PASS COMP | 55.00% | 8 | WIN |
| KC@PHI | JALEN HURTS LONGEST RUSH OVER 12.5 YDS | 55.60% | 8 | WIN |
| BUF@KC | DALTON KINCAID OVER 29.5 RECV YDS | 55.10% | 8 | LOSS |
| WAS@PHI | DEVONTA SMITH OVER 3.5 RECEPTIONS | 55.80% | 8 | WIN |
| BUF@KC | JAMES COOK ANYTIME TD | 53.00% | 5 | WIN |
| LAR@PHI | SAQUON BARKLEY UNDER 128 RUSH + REC YDS | 53.20% | 5 | LOSS |
| BAL@BUF | LAMAR JACKSON OVER 54.5 RUSH YDS | 54.50% | 6 | LOSS |
| HOU@KC | C.J. STROUD RUSH YDS UNDER 14.5 | 53.10% | 5 | LOSS |
| WAS@DET | JAMESON WILLIAMS RUSH YDS OVER 1.5 | 53.30% | 5 | WIN |
| WAS@DET | JARED GOFF PASS COMP % UNDER 72.3 | 54.30% | 6 | WIN |
| MIN@LAR | COOPER KUPP ANYTIME TOUCHDOWN | 52.60% | 3 | LOSS |
| MIN@LAR | MATTHEW STAFFORD OVER 21.5 PASS COMP | 54.10% | 6 | LOSS |
| WAS@TB | BRIAN ROBINSON JR OVER 1.5 REC TARGETS | 53.50% | 5 | WIN |
| WAS@TB | BAKER MAYFIELD UNDER 33.5 PASS ATT | 54.90% | 6 | WIN |
| GB@PHI | JALEN HURTS OVER 67.1 PASS COMP PERCENTAGE | 54.60% | 6 | LOSS |
| LAC@HOU | J.K. DOBBINS ANYTIME TD | 52.80% | 3 | LOSS |
| LAC@HOU | LAC -2.5 | 53.40% | 3 | LOSS |
| LAC@HOU | JUSTIN HERBERT OVER 19.5 RUSH YDS | 53.40% | 5 | LOSS |