Steelers vs Colts Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 29)

Updated: 2024-09-22T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Pittsburgh Steelers will face the Indianapolis Colts on September 29, 2024, at Lucas Oil Stadium. The Steelers come in undefeated at 3-0, while the Colts sit at 1-2, aiming to rebound after a mixed start to the season. This AFC matchup pits the Steelers’ dominant defense against the Colts’ improving offense led by Anthony Richardson.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 29, 2024

Start Time: 1:00 PM EST​

Venue: Lucas Oil Stadium​

Colts Record: (1-2)

Steelers Record: (3-0)

OPENING ODDS

PIT Moneyline: -126

IND Moneyline: +106

PIT Spread: -1.5

IND Spread: +1.5

Over/Under: 40

PIT
Betting Trends

  • The Steelers have been strong ATS this season, covering the spread in all three of their games. They’ve maintained solid performances, especially as favorites, going 5-2 ATS in their last seven road games.

IND
Betting Trends

  • The Colts are 2-1 ATS so far in 2024, but they have been inconsistent, especially at home. They failed to cover the spread in their Week 2 loss to the Packers but bounced back ATS in their last outing against the Bears.

MATCHUP TRENDS

  • In their last five head-to-head matchups, the Steelers have gone 4-1 ATS against the Colts, showing dominance in recent years. Additionally, the UNDER has hit in 7 of the last 10 meetings between these teams, suggesting a trend toward lower-scoring games.

PIT vs. IND
Best Prop Bet

  • Remi's searched hard and found the best Prop Bet for this matchup: Najee Harris Anytime Touchdown.

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Pittsburgh vs Indianapolis Prediction & Odds:
Free NFL Betting Insights for 9/29/24

The Pittsburgh Steelers and Indianapolis Colts square off in a Week 4 AFC showdown with both teams heading in different directions early in the 2024 season. The Steelers come into the game with a perfect 3-0 record, largely due to their top-ranked defense, which has allowed only 8.7 points per game. Led by Justin Fields, the Steelers’ offense has been efficient but has relied heavily on their defensive unit, spearheaded by T.J. Watt, who leads the team with 3 sacks. The Colts, meanwhile, are still finding their footing under second-year quarterback Anthony Richardson.

Despite their 1-2 record, Richardson has shown flashes of brilliance, particularly with his dual-threat capabilities. Indianapolis’ offensive focal point remains running back Jonathan Taylor, who has been the workhorse with 261 rushing yards and 2 touchdowns through three games. Taylor will be critical in helping the Colts control the clock and keep the Steelers’ pass rush at bay. The Steelers are favored by 1.5 points heading into the game, and their recent dominance over the Colts gives them an edge. Pittsburgh’s defense will likely key in on limiting Taylor’s production and forcing Richardson to beat them through the air. For the Colts to pull off an upset, they will need to protect Richardson and create opportunities for Taylor to exploit Pittsburgh’s defense. The game total is set at 40 points, indicating expectations of a low-scoring contest, which aligns with both teams’ recent performances.

Pittsburgh Steelers NFL Preview

The Pittsburgh Steelers have started the 2024 season red-hot with a 3-0 record, and they’ll look to keep the momentum going against the Colts. Pittsburgh’s success has been largely driven by their defense, which has allowed a league-low 8.7 points per game. Linebacker T.J. Watt has been dominant, leading the team with 3 sacks and numerous pressures on opposing quarterbacks. The Steelers’ defense has also excelled at stopping the run, allowing just 71.3 rushing yards per game, which will be key in neutralizing Jonathan Taylor. Offensively, Justin Fields has managed games well, throwing for 518 yards and 3 touchdowns. While the Steelers’ passing game hasn’t been explosive, wide receiver George Pickens has emerged as a reliable target, leading the team with 171 receiving yards. Running back Najee Harris is still the centerpiece of the ground attack, amassing 209 rushing yards, and he will be critical in wearing down the Colts’ vulnerable run defense. Pittsburgh’s recent success ATS, covering in all three games this season, makes them the favorites in this matchup. Their defensive strength and ability to control the pace of the game give them a significant advantage over the Colts. For Pittsburgh to continue their unbeaten run, they’ll need to pressure Richardson into mistakes and establish the run early to control the tempo.

The Pittsburgh Steelers will face the Indianapolis Colts on September 29, 2024, at Lucas Oil Stadium. The Steelers come in undefeated at 3-0, while the Colts sit at 1-2, aiming to rebound after a mixed start to the season. This AFC matchup pits the Steelers’ dominant defense against the Colts’ improving offense led by Anthony Richardson. Pittsburgh vs Indianapolis AI Prediction: Free NFL Betting Insights for Sep 29. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Indianapolis Colts NFL Preview

The Indianapolis Colts have had an up-and-down start to the 2024 season, entering Week 4 with a 1-2 record. Under head coach Shane Steichen, the Colts are gradually building an offense around quarterback Anthony Richardson and running back Jonathan Taylor. Richardson has flashed potential but remains a work in progress, with 583 passing yards and 4 touchdowns through three games. Taylor, the engine of the offense, is off to a solid start, rushing for 261 yards and 2 touchdowns, and he’ll be crucial in slowing down the Steelers’ aggressive defense. Defensively, the Colts have struggled to stop the run, allowing an average of 179 rushing yards per game. This weakness will be particularly concerning against a Pittsburgh offense that relies on balance, with Najee Harris and Jaylen Warren contributing effectively on the ground. Indianapolis will need a strong performance from DeForest Buckner and the defensive front to limit the Steelers’ rushing attack and generate pressure on Fields. The Colts are 1-1 at home this season but have struggled to cover the spread in key games. If they can establish the run with Taylor and protect Richardson from Pittsburgh’s fierce pass rush, they’ll have a chance to pull off an upset. However, without a clean game from their young quarterback, the Colts could find themselves overwhelmed by Pittsburgh’s disciplined defense.

Pittsburgh vs. Indianapolis Prop Picks (AI)

Remi is pouring through loads of datapoints on each line. In fact, anytime the Steelers and Colts play there’s always several intriguing trends to key in on. Not to mention games played at Lucas Oil Stadium in Sep almost always follow normal, predictable betting trends.
Remi's searched hard and found the best Prop Bet for this matchup: Najee Harris Anytime Touchdown.

Pittsburgh vs. Indianapolis Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every angle between the Steelers and Colts and using recursive machine learning and industry leading AI to examine the data to a single cover probability.

Remi has been most fixated on the unproportionally assigned emphasis human bettors tend to put on Pittsburgh’s strength factors between a Steelers team going up against a possibly tired Colts team. In reality, the true game analytics might reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Pittsburgh vs Indianapolis picks, computer picks Steelers vs Colts, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NFL 10/20 HOU@SEA UNLOCK THIS PICK 5 INTEL Locked INTEL
NFL 10/20 TB@DET UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/20 TB@DET UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/20 TB@DET UNLOCK THIS PICK 1 INTEL Locked INTEL
NFL 10/20 HOU@SEA UNLOCK THIS PICK 0 INTEL Locked INTEL
NFL 10/20 TB@DET UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Steelers Betting Trends

The Steelers have been strong ATS this season, covering the spread in all three of their games. They’ve maintained solid performances, especially as favorites, going 5-2 ATS in their last seven road games.

Colts Betting Trends

The Colts are 2-1 ATS so far in 2024, but they have been inconsistent, especially at home. They failed to cover the spread in their Week 2 loss to the Packers but bounced back ATS in their last outing against the Bears.

Steelers vs. Colts Matchup Trends

In their last five head-to-head matchups, the Steelers have gone 4-1 ATS against the Colts, showing dominance in recent years. Additionally, the UNDER has hit in 7 of the last 10 meetings between these teams, suggesting a trend toward lower-scoring games.

Pittsburgh vs. Indianapolis Game Info

Pittsburgh vs Indianapolis starts on September 29, 2024 at 1:00 PM EST.

Spread: Indianapolis +1.5
Moneyline: Pittsburgh -126, Indianapolis +106
Over/Under: 40

Pittsburgh: (3-0)  |  Indianapolis: (1-2)

Remi's searched hard and found the best Prop Bet for this matchup: Najee Harris Anytime Touchdown.. Prices move—always shop for the best number.

In their last five head-to-head matchups, the Steelers have gone 4-1 ATS against the Colts, showing dominance in recent years. Additionally, the UNDER has hit in 7 of the last 10 meetings between these teams, suggesting a trend toward lower-scoring games.

PIT trend: The Steelers have been strong ATS this season, covering the spread in all three of their games. They’ve maintained solid performances, especially as favorites, going 5-2 ATS in their last seven road games.

IND trend: The Colts are 2-1 ATS so far in 2024, but they have been inconsistent, especially at home. They failed to cover the spread in their Week 2 loss to the Packers but bounced back ATS in their last outing against the Bears.

See our latest NFL picks and odds pages for 2024 to compare prices before you bet.

Pittsburgh vs. Indianapolis Odds

Remi is pouring through mountains of data points on each team. In fact, anytime the Pittsburgh vs Indianapolis trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable betting trends.

Pittsburgh vs Indianapolis Opening Odds

PIT Moneyline: -126
IND Moneyline: +106
PIT Spread: -1.5
IND Spread: +1.5
Over/Under: 40

Pittsburgh vs Indianapolis Live Odds

Games PTS ML SPR O/U
Oct 23, 2025 8:15PM EDT
Minnesota Vikings
Los Angeles Chargers
10/23/25 8:15PM
Vikings
Chargers
+148
-185
+3 (+100)
-3 (-120)
O 44.5 (-110)
U 44.5 (-110)
Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
+270
-374
+7 (-110)
-7 (-110)
O 40.5 (-110)
U 40.5 (-110)
Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
-463
+321
-7.5 (-110)
+7.5 (-110)
O 46 (-110)
U 46 (-110)
Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
+242
-330
+7 (-110)
-7 (-110)
O 44.5 (-110)
U 44.5 (-110)
Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
+229
-315
+6.5 (+100)
-6.5 (-120)
O 50.5 (-110)
U 50.5 (-110)
Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
+287
-407
+7 (-110)
-7 (-110)
O 43.5 (-110)
U 43.5 (-110)
Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
-110
-116
+1 (-110)
-1 (-110)
O 41.5 (-110)
U 41.5 (-110)
Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
+257
-355
+7 (-110)
-7 (-110)
O 44.5 (-110)
U 44.5 (-110)
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
-220
+169
-4.5 (-110)
+4.5 (-110)
O 47 (-110)
U 47 (-110)
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
+141
-181
+3.5 (-120)
-3.5 (+100)
O 50 (-110)
U 50 (-110)
Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
+682
-1442
+14 (-110)
-14 (-110)
O 47 (-110)
U 47 (-110)
Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
-192
+148
-3.5 (+100)
+3.5 (-120)
O 44.5 (-110)
U 44.5 (-110)
Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
+390
-599
+10.5 (-110)
-10.5 (-110)
O 47.5 (-110)
U 47.5 (-110)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Pittsburgh Steelers vs. Indianapolis Colts on September 29, 2024 at Lucas Oil Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS
HOU@BAL HOU -125 58.5% 7 WIN
DET@CIN DET -10 55.6% 5 WIN
DAL@NYJ NYJ +1.5 53.7% 3 LOSS
TB@SEA TB +3.5 54.9% 4 WIN
TEN@ARI ARI -7 (BUY 0.5) 54.9% 4 LOSS
DEN@PHI DEN +4.5 57.5% 7 WIN
MIA@CAR TETAIROA MCMILLAN OVER 58.5 RECV YDS 54.5% 4 WIN
LV@IND ASHTON JEANTY UNDER 67.5 RUSH YDS 54.4% 4 WIN
SF@LAR DEMARCUS ROBINSON OVER 29.5 RECV YDS 55.7% 5 WIN
NYJ@MIA NYJ +3 53.8 3 LOSS
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS
TEN@HOU TEN +7.5 57.9% 7 LOSS
LAC@NYG LAC -6 57.3% 7 LOSS
NO@BUF UNDER 48.5 55.1% 3 LOSS
GB@DAL JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS 55.5% 5 LOSS
CAR@NE DRAKE MAYE TO THROW AN INT 56.6% 6 LOSS
SEA@ARI SEA -125 57.7% 6 WIN
SEA@ARI KYLER MURRAY TO THROW AN INT 56.6% 6 WIN
DET@BAL JAHMYR GIBBS OVER 0.5 RUSH TDS 55.8% 5 WIN
DAL@CHI DAL -120 58.7% 6 LOSS
PIT@NE PIT -116 60.1% 6 WIN
ATL@CAR ATL -4.5 55.4% 5 LOSS
LV@WAS LV +3 54.3% 4 LOSS