Steelers vs Colts Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 29)
Updated: 2024-09-22T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Pittsburgh Steelers will face the Indianapolis Colts on September 29, 2024, at Lucas Oil Stadium. The Steelers come in undefeated at 3-0, while the Colts sit at 1-2, aiming to rebound after a mixed start to the season. This AFC matchup pits the Steelers’ dominant defense against the Colts’ improving offense led by Anthony Richardson.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 29, 2024
Start Time: 1:00 PM EST
Venue: Lucas Oil Stadium
Colts Record: (1-2)
Steelers Record: (3-0)
OPENING ODDS
PIT Moneyline: -126
IND Moneyline: +106
PIT Spread: -1.5
IND Spread: +1.5
Over/Under: 40
PIT
Betting Trends
- The Steelers have been strong ATS this season, covering the spread in all three of their games. They’ve maintained solid performances, especially as favorites, going 5-2 ATS in their last seven road games.
IND
Betting Trends
- The Colts are 2-1 ATS so far in 2024, but they have been inconsistent, especially at home. They failed to cover the spread in their Week 2 loss to the Packers but bounced back ATS in their last outing against the Bears.
MATCHUP TRENDS
- In their last five head-to-head matchups, the Steelers have gone 4-1 ATS against the Colts, showing dominance in recent years. Additionally, the UNDER has hit in 7 of the last 10 meetings between these teams, suggesting a trend toward lower-scoring games.
PIT vs. IND
Best Prop Bet
- Remi's searched hard and found the best Prop Bet for this matchup: Najee Harris Anytime Touchdown.
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Pittsburgh vs Indianapolis Prediction & Odds:
Free NFL Betting Insights for 9/29/24
Despite their 1-2 record, Richardson has shown flashes of brilliance, particularly with his dual-threat capabilities. Indianapolis’ offensive focal point remains running back Jonathan Taylor, who has been the workhorse with 261 rushing yards and 2 touchdowns through three games. Taylor will be critical in helping the Colts control the clock and keep the Steelers’ pass rush at bay. The Steelers are favored by 1.5 points heading into the game, and their recent dominance over the Colts gives them an edge. Pittsburgh’s defense will likely key in on limiting Taylor’s production and forcing Richardson to beat them through the air. For the Colts to pull off an upset, they will need to protect Richardson and create opportunities for Taylor to exploit Pittsburgh’s defense. The game total is set at 40 points, indicating expectations of a low-scoring contest, which aligns with both teams’ recent performances.
No traffic when you create your own lane 💨 @justnfields
— Pittsburgh Steelers (@steelers) September 24, 2024
📺: #PITvsIND 9/29 at 1 PM ET on CBS pic.twitter.com/9zstw5RUKb
Pittsburgh Steelers NFL Preview
The Pittsburgh Steelers have started the 2024 season red-hot with a 3-0 record, and they’ll look to keep the momentum going against the Colts. Pittsburgh’s success has been largely driven by their defense, which has allowed a league-low 8.7 points per game. Linebacker T.J. Watt has been dominant, leading the team with 3 sacks and numerous pressures on opposing quarterbacks. The Steelers’ defense has also excelled at stopping the run, allowing just 71.3 rushing yards per game, which will be key in neutralizing Jonathan Taylor. Offensively, Justin Fields has managed games well, throwing for 518 yards and 3 touchdowns. While the Steelers’ passing game hasn’t been explosive, wide receiver George Pickens has emerged as a reliable target, leading the team with 171 receiving yards. Running back Najee Harris is still the centerpiece of the ground attack, amassing 209 rushing yards, and he will be critical in wearing down the Colts’ vulnerable run defense. Pittsburgh’s recent success ATS, covering in all three games this season, makes them the favorites in this matchup. Their defensive strength and ability to control the pace of the game give them a significant advantage over the Colts. For Pittsburgh to continue their unbeaten run, they’ll need to pressure Richardson into mistakes and establish the run early to control the tempo.

Credit: USA TODAY/IMAGN
Indianapolis Colts NFL Preview
The Indianapolis Colts have had an up-and-down start to the 2024 season, entering Week 4 with a 1-2 record. Under head coach Shane Steichen, the Colts are gradually building an offense around quarterback Anthony Richardson and running back Jonathan Taylor. Richardson has flashed potential but remains a work in progress, with 583 passing yards and 4 touchdowns through three games. Taylor, the engine of the offense, is off to a solid start, rushing for 261 yards and 2 touchdowns, and he’ll be crucial in slowing down the Steelers’ aggressive defense. Defensively, the Colts have struggled to stop the run, allowing an average of 179 rushing yards per game. This weakness will be particularly concerning against a Pittsburgh offense that relies on balance, with Najee Harris and Jaylen Warren contributing effectively on the ground. Indianapolis will need a strong performance from DeForest Buckner and the defensive front to limit the Steelers’ rushing attack and generate pressure on Fields. The Colts are 1-1 at home this season but have struggled to cover the spread in key games. If they can establish the run with Taylor and protect Richardson from Pittsburgh’s fierce pass rush, they’ll have a chance to pull off an upset. However, without a clean game from their young quarterback, the Colts could find themselves overwhelmed by Pittsburgh’s disciplined defense.
Our unofficial depth chart for #PITvsIND.
— Indianapolis Colts (@Colts) September 24, 2024
Pittsburgh vs. Indianapolis Prop Picks (AI)
Pittsburgh vs. Indianapolis Prediction (AI)

Remi, our AI sports genius, has been pouring over tons of data from every angle between the Steelers and Colts and using recursive machine learning and industry leading AI to examine the data to a single cover probability.
Remi has been most fixated on the unproportionally assigned emphasis human bettors tend to put on Pittsburgh’s strength factors between a Steelers team going up against a possibly tired Colts team. In reality, the true game analytics might reflect a strong lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Pittsburgh vs Indianapolis picks, computer picks Steelers vs Colts, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 5 |
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NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 1 |
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NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 0 |
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NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Steelers Betting Trends
The Steelers have been strong ATS this season, covering the spread in all three of their games. They’ve maintained solid performances, especially as favorites, going 5-2 ATS in their last seven road games.
Colts Betting Trends
The Colts are 2-1 ATS so far in 2024, but they have been inconsistent, especially at home. They failed to cover the spread in their Week 2 loss to the Packers but bounced back ATS in their last outing against the Bears.
Steelers vs. Colts Matchup Trends
In their last five head-to-head matchups, the Steelers have gone 4-1 ATS against the Colts, showing dominance in recent years. Additionally, the UNDER has hit in 7 of the last 10 meetings between these teams, suggesting a trend toward lower-scoring games.
Pittsburgh vs. Indianapolis Game Info
What time does Pittsburgh vs Indianapolis start on September 29, 2024?
Pittsburgh vs Indianapolis starts on September 29, 2024 at 1:00 PM EST.
Where is Pittsburgh vs Indianapolis being played?
Venue: Lucas Oil Stadium.
What are the opening odds for Pittsburgh vs Indianapolis?
Spread: Indianapolis +1.5
Moneyline: Pittsburgh -126, Indianapolis +106
Over/Under: 40
What are the records for Pittsburgh vs Indianapolis?
Pittsburgh: (3-0) | Indianapolis: (1-2)
What is the AI best bet for Pittsburgh vs Indianapolis?
Remi's searched hard and found the best Prop Bet for this matchup: Najee Harris Anytime Touchdown.. Prices move—always shop for the best number.
What are Pittsburgh vs Indianapolis trending bets?
In their last five head-to-head matchups, the Steelers have gone 4-1 ATS against the Colts, showing dominance in recent years. Additionally, the UNDER has hit in 7 of the last 10 meetings between these teams, suggesting a trend toward lower-scoring games.
What are Pittsburgh trending bets?
PIT trend: The Steelers have been strong ATS this season, covering the spread in all three of their games. They’ve maintained solid performances, especially as favorites, going 5-2 ATS in their last seven road games.
What are Indianapolis trending bets?
IND trend: The Colts are 2-1 ATS so far in 2024, but they have been inconsistent, especially at home. They failed to cover the spread in their Week 2 loss to the Packers but bounced back ATS in their last outing against the Bears.
Where can I find AI Picks for Pittsburgh vs Indianapolis?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
Pittsburgh vs. Indianapolis Odds
Remi is pouring through mountains of data points on each team. In fact, anytime the Pittsburgh vs Indianapolis trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable betting trends.
Pittsburgh vs Indianapolis Opening Odds
PIT Moneyline:
-126 IND Moneyline: +106
PIT Spread: -1.5
IND Spread: +1.5
Over/Under: 40
Pittsburgh vs Indianapolis Live Odds
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-110
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+1 (-110)
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O 41.5 (-110)
U 41.5 (-110)
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Oct 26, 2025 1:00PM EDT
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Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
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-220
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U 50 (-110)
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O 47 (-110)
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-192
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O 44.5 (-110)
U 44.5 (-110)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Pittsburgh Steelers vs. Indianapolis Colts on September 29, 2024 at Lucas Oil Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
GB@ARI | ARI +7 | 54.8% | 5 | WIN |
NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
DET@CIN | DET -10 | 55.6% | 5 | WIN |
DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
PIT@NE | PIT -116 | 60.1% | 6 | WIN |
ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
LV@WAS | LV +3 | 54.3% | 4 | LOSS |