Patriots vs. 49ers
Prediction, Odds & Props
Sep 29 | NFL AI Picks
Updated: 2024-09-22T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The New England Patriots travel to face the San Francisco 49ers on September 29, 2024, at Levi’s Stadium. Both teams enter the matchup with 1-2 records and are in desperate need of a win to avoid falling further in their respective divisions.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 29, 2024
Start Time: 4:05 PM EST
Venue: Levi's Stadium
49ers Record: (1-2)
Patriots Record: (1-2)
OPENING ODDS
NE Moneyline: +400
SF Moneyline: -543
NE Spread: +10
SF Spread: -10.0
Over/Under: 39.5
NE
Betting Trends
- The Patriots have struggled against the spread (ATS) this season, going 1-2 overall. They are 4-1 ATS in their last five road games, though they’ve lost six consecutive games against NFC opponents.
SF
Betting Trends
- The 49ers are 1-2 ATS this season, and they’ve gone 1-7 ATS in their last eight home games, reflecting some inconsistency in covering spreads, especially at Levi’s Stadium.
MATCHUP TRENDS
- In their last six matchups, the UNDER has hit in five of those games between the Patriots and 49ers, suggesting a trend of lower-scoring affairs when these teams meet.
NE vs. SF
Best Prop Bet
- Remi's searched hard and found the best Prop Bet for this matchup :Brandon Aiyuk Anytime Touchdown.
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New England vs San Francisco Prediction & Odds:
Free NFL Betting Insights for 9/29/24
The Patriots’ offense has been one of the worst in the league, averaging just 13 points per game. Quarterback Jacoby Brissett has struggled behind an underperforming offensive line, and their run game, featuring Rhamondre Stevenson and Antonio Gibson, has failed to get off the ground. New England’s defense, however, remains solid, allowing just 19 points per game. They will need to find a way to contain the 49ers’ balanced attack, especially if they hope to turn their season around. San Francisco, led by Brock Purdy, has been efficient offensively, averaging 24.3 points per game. However, injuries to key players like Christian McCaffrey and George Kittle have hindered their production. Despite the injuries, Jordan Mason has filled in admirably at running back, and the 49ers will look to exploit the Patriots’ vulnerable offensive line with their star pass rusher, Nick Bosa. The 49ers enter as 10-point favorites, and this game could come down to how well their defense handles the Patriots’ struggling offense. Given New England’s difficulties moving the ball and San Francisco’s potent offense, the 49ers will be looking to secure a much-needed home win.
Join us at home for a match with Miami.
— New England Patriots (@Patriots) September 24, 2024
Enter for the chance to win tickets to Week 5 at @GilletteStadium: https://t.co/y47HztHQb6 pic.twitter.com/evo1LaHN8K
New England Patriots NFL Preview
The New England Patriots are coming off a demoralizing 24-3 loss to the Jets, and they’ll need to quickly fix their offensive woes to avoid falling further in the standings. Jacoby Brissett has struggled under center, completing just 12 of 18 passes for 98 yards in their last outing. The running game, featuring Rhamondre Stevenson, has been underwhelming, and the Patriots’ offensive line has been unable to protect Brissett or open lanes for the rushing attack. Defensively, New England continues to be a bright spot. They rank 10th in points allowed per game, giving up just 19 points per contest. However, the unit will face a tough challenge against a balanced 49ers offense led by Brock Purdy. The Patriots’ secondary will need to limit the deep passes to Jauan Jennings, while their front seven will be tasked with slowing down Jordan Mason on the ground. For the Patriots to stand a chance, they’ll need a much-improved performance from their offense. They have to establish the run early and keep the 49ers’ defense on their heels. If New England can avoid turnovers and control time of possession, they might be able to keep this game closer than expected.
Credit: USA TODAY/IMAGN
San Francisco 49ers NFL Preview
The San Francisco 49ers enter this game eager to bounce back from a narrow loss to the Rams, which saw them lose a 4th-quarter lead. Brock Purdy has been solid this season, throwing for 842 yards and four touchdowns, but the injuries to key players like Christian McCaffrey and George Kittle have impacted the offense’s ability to close out games. Running back Jordan Mason has stepped in well, rushing for 324 yards, and wide receiver Jauan Jennings has become a reliable target in the passing game. Defensively, the 49ers’ front seven remains one of the strongest in the league, led by Nick Bosa and Fred Warner. They have allowed 104 rushing yards per game, and Bosa will look to disrupt Brissett behind the Patriots’ struggling offensive line. With the Patriots’ offense ranking near the bottom of the league, the 49ers’ defense will aim to dominate the line of scrimmage and force turnovers. At home, the 49ers will be looking to improve their 1-1 record and avoid falling to 1-3, especially in a competitive NFC West division. Their ability to pressure Brissett and control the clock with their ground game will be key to securing a win.
For the culture ❤️
— San Francisco 49ers (@49ers) September 18, 2024
¡Somos Los 49ers y somos fiel a la cultura! pic.twitter.com/J6dWIXbip5
New England vs. San Francisco Prop Picks (AI)
New England vs. San Francisco Prediction (AI)
Remi, our AI sports algorithm, has been pouring over millions of data from every simulation between the Patriots and 49ers and using recursive machine learning and cutting-edge AI to boil down the data to a single cover probability.
Interestingly enough, the data has been most watching on the growing emphasis knucklehead sportsbettors often put on coaching factors between a Patriots team going up against a possibly deflated 49ers team. Trends look to say the true game analytics might reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI New England vs San Francisco picks, computer picks Patriots vs 49ers, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Patriots Betting Trends
The Patriots have struggled against the spread (ATS) this season, going 1-2 overall. They are 4-1 ATS in their last five road games, though they’ve lost six consecutive games against NFC opponents.
49ers Betting Trends
The 49ers are 1-2 ATS this season, and they’ve gone 1-7 ATS in their last eight home games, reflecting some inconsistency in covering spreads, especially at Levi’s Stadium.
Patriots vs. 49ers Matchup Trends
In their last six matchups, the UNDER has hit in five of those games between the Patriots and 49ers, suggesting a trend of lower-scoring affairs when these teams meet.
New England vs. San Francisco Game Info
What time does New England vs San Francisco start on September 29, 2024?
New England vs San Francisco starts on September 29, 2024 at 4:05 PM EST.
Where is New England vs San Francisco being played?
Venue: Levi's Stadium.
What are the opening odds for New England vs San Francisco?
Spread: San Francisco -10.0
Moneyline: New England +400, San Francisco -543
Over/Under: 39.5
What are the records for New England vs San Francisco?
New England: (1-2) | San Francisco: (1-2)
What is the AI best bet for New England vs San Francisco?
Remi's searched hard and found the best Prop Bet for this matchup :Brandon Aiyuk Anytime Touchdown.. Prices move—always shop for the best number.
What are New England vs San Francisco trending bets?
In their last six matchups, the UNDER has hit in five of those games between the Patriots and 49ers, suggesting a trend of lower-scoring affairs when these teams meet.
What are New England trending bets?
NE trend: The Patriots have struggled against the spread (ATS) this season, going 1-2 overall. They are 4-1 ATS in their last five road games, though they’ve lost six consecutive games against NFC opponents.
What are San Francisco trending bets?
SF trend: The 49ers are 1-2 ATS this season, and they’ve gone 1-7 ATS in their last eight home games, reflecting some inconsistency in covering spreads, especially at Levi’s Stadium.
Where can I find AI Picks for New England vs San Francisco?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
New England vs. San Francisco Odds
Remi is pouring through loads of stats on each player. In fact, anytime the New England vs San Francisco trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable betting trends.
New England vs San Francisco Opening Odds
NE Moneyline:
+400 SF Moneyline: -543
NE Spread: +10
SF Spread: -10.0
Over/Under: 39.5
New England vs San Francisco Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Sep 28, 2025 9:31AM EDT
Minnesota Vikings
Pittsburgh Steelers
9/28/25 9:31AM
Vikings
Steelers
|
–
–
|
-140
+115
|
-2.5 (-115)
+2.5 (-105)
|
O 41 (-110)
U 41 (-110)
|
|
|
Sep 28, 2025 1:00PM EDT
Cleveland Browns
Detroit Lions
9/28/25 1PM
Browns
Lions
|
–
–
|
+400
-550
|
+10 (-110)
-10 (-110)
|
O 44.5 (-105)
U 44.5 (-115)
|
|
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Sep 28, 2025 1:00PM EDT
Los Angeles Chargers
New York Giants
9/28/25 1PM
Chargers
Giants
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–
–
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-285
+230
|
-6.5 (-105)
+6.5 (-115)
|
O 44 (-110)
U 44 (-110)
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|
|
Sep 28, 2025 1:01PM EDT
Tennessee Titans
Houston Texans
9/28/25 1:01PM
Titans
Texans
|
–
–
|
+300
-375
|
+7 (-105)
-7 (-115)
|
O 39 (-110)
U 39 (-110)
|
|
|
Sep 28, 2025 1:01PM EDT
Philadelphia Eagles
Tampa Bay Buccaneers
9/28/25 1:01PM
Eagles
Buccaneers
|
–
–
|
-190
+160
|
-3.5 (-105)
+3.5 (-115)
|
O 44 (-110)
U 44 (-110)
|
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Sep 28, 2025 1:01PM EDT
Washington Commanders
Atlanta Falcons
9/28/25 1:01PM
Commanders
Falcons
|
–
–
|
+110
-130
|
+2 (-110)
-2 (-110)
|
O 43.5 (-110)
U 43.5 (-110)
|
|
|
Sep 28, 2025 1:01PM EDT
New Orleans Saints
Buffalo Bills
9/28/25 1:01PM
Saints
Bills
|
–
–
|
+800
-1300
|
+15 (-110)
-15 (-110)
|
O 48 (-110)
U 48 (-110)
|
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Sep 28, 2025 1:01PM EDT
Carolina Panthers
New England Patriots
9/28/25 1:01PM
Panthers
Patriots
|
–
–
|
+200
-250
|
+5.5 (-110)
-5.5 (-110)
|
O 43 (-110)
U 43 (-110)
|
|
|
Sep 28, 2025 4:06PM EDT
Jacksonville Jaguars
San Francisco 49ers
9/28/25 4:06PM
Jaguars
49ers
|
–
–
|
+150
-180
|
+3.5 (-115)
-3.5 (-105)
|
O 46.5 (-110)
U 46.5 (-110)
|
|
|
Sep 28, 2025 4:06PM EDT
Indianapolis Colts
Los Angeles Rams
9/28/25 4:06PM
Colts
Rams
|
–
–
|
+160
-190
|
+3.5 (-110)
-3.5 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
|
Sep 28, 2025 4:25PM EDT
Baltimore Ravens
Kansas City Chiefs
9/28/25 4:25PM
Ravens
Chiefs
|
–
–
|
-150
+125
|
-2.5 (-120)
+2.5 (+100)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
|
Sep 28, 2025 4:26PM EDT
Chicago Bears
Las Vegas Raiders
9/28/25 4:26PM
Bears
Raiders
|
–
–
|
+100
-120
|
+1 (-110)
-1 (-110)
|
O 48 (-110)
U 48 (-110)
|
|
|
Sep 28, 2025 8:21PM EDT
Green Bay Packers
Dallas Cowboys
9/28/25 8:21PM
Packers
Cowboys
|
–
–
|
-325
+250
|
-7 (-105)
+7 (-115)
|
O 47 (-110)
U 47 (-110)
|
|
|
Sep 29, 2025 7:15PM EDT
New York Jets
Miami Dolphins
9/29/25 7:15PM
Jets
Dolphins
|
–
–
|
+125
-150
|
+3 (-115)
-3 (-105)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Sep 29, 2025 8:15PM EDT
Cincinnati Bengals
Denver Broncos
9/29/25 8:15PM
Bengals
Broncos
|
–
–
|
+310
-400
|
+7.5 (-110)
-7.5 (-110)
|
O 44 (-110)
U 44 (-110)
|
|
|
Oct 2, 2025 8:16PM EDT
San Francisco 49ers
Los Angeles Rams
10/2/25 8:16PM
49ers
Rams
|
–
–
|
+134
-158
|
+3 (-105)
-3 (-115)
|
O 47 (-110)
U 47 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers New England Patriots vs. San Francisco 49ers on September 29, 2024 at Levi's Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |
| GB@CLE | GB -7 | 54.3% | 4 | LOSS |
| ARI@SF | ARI +3 | 57.7% | 6 | WIN |
| KC@NYG | PATRICK MAHOMES OVER 230.5 PASS YDS | 54.7% | 4 | WIN |
| GB@CLE | JOE FLACCO OVER 37.5 PASS ATT | 56.6% | 6 | LOSS |
| MIA@BUF | TYREEK HILL OVER 5.5 TOTAL RECEPTIONS | 56.8% | 6 | LOSS |
| LAC@LV | LAC -3 | 54.9% | 4 | WIN |
| TB@HOU | BAKER MAYFIELD OVER 1.5 PASS TDS | 54.4% | 4 | WIN |
| CHI@DET | DET -6.5 | 54.3% | 4 | WIN |
| DEN@IND | DEN -118 | 60.1% | 10 | LOSS |
| PHI@KC | PHI -115 | 56.7% | 6 | WIN |
| SF@NO | SF -3 | 58.8% | 8 | WIN |
| SEA@PIT | OVER 40 | 54.9% | 4 | WIN |
| CAR@ARI | BRYCE YOUNG INTERCEPTIONS UNDER 0.5 | 56.4% | 6 | LOSS |
| DEN@IND | JOSH DOWNS RECEPTIONS OVER 3.5 | 54.7% | 4 | WIN |
| ATL@MIN | BIJAN ROBINSON RUSH + REC YDS OVER 94.5 | 53.4% | 3 | WIN |
| WAS@GB | WAS +3.5 | 56.5% | 6 | LOSS |
| WAS@GB | JORDAN LOVE OVER 5.5 RUSH YDS | 54.7% | 4 | WIN |
| MIN@CHI | CALEB WILLIAMS OVER 219.5 PASS YDS | 53.4% | 3 | LOSS |
| TEN@DEN | DEN -8.5 | 55.3% | 5 | LOSS |
| SF@SEA | SF -115 | 54.6% | 4 | WIN |
| SF@SEA | KENNETH WALKER III UNDER 79.5 RUSH+REC YDS | 54.6% | 4 | WIN |
| CAR@JAC | TANK BIGSBY OVER 10.5 RUSH ATT | 56.1% | 6 | LOSS |
| KC@LAC | JUSTIN HERBERT UNDER 0.5 INT | 54.1% | 3 | WIN |
| DAL@PHI | GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS | 54.1% | 4 | LOSS |
| KC@PHI | JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS | 53.90% | 5 | WIN |
| KC@PHI | DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS | 54.40% | 6 | WIN |
| KC@PHI | PATRICK MAHOMES UNDER 68.3% PASS COMP | 55.00% | 8 | WIN |
| KC@PHI | JALEN HURTS LONGEST RUSH OVER 12.5 YDS | 55.60% | 8 | WIN |
| BUF@KC | DALTON KINCAID OVER 29.5 RECV YDS | 55.10% | 8 | LOSS |
| WAS@PHI | DEVONTA SMITH OVER 3.5 RECEPTIONS | 55.80% | 8 | WIN |
| BUF@KC | JAMES COOK ANYTIME TD | 53.00% | 5 | WIN |
| LAR@PHI | SAQUON BARKLEY UNDER 128 RUSH + REC YDS | 53.20% | 5 | LOSS |
| BAL@BUF | LAMAR JACKSON OVER 54.5 RUSH YDS | 54.50% | 6 | LOSS |
| HOU@KC | C.J. STROUD RUSH YDS UNDER 14.5 | 53.10% | 5 | LOSS |
| WAS@DET | JAMESON WILLIAMS RUSH YDS OVER 1.5 | 53.30% | 5 | WIN |
| WAS@DET | JARED GOFF PASS COMP % UNDER 72.3 | 54.30% | 6 | WIN |
| MIN@LAR | COOPER KUPP ANYTIME TOUCHDOWN | 52.60% | 3 | LOSS |
| MIN@LAR | MATTHEW STAFFORD OVER 21.5 PASS COMP | 54.10% | 6 | LOSS |
| WAS@TB | BRIAN ROBINSON JR OVER 1.5 REC TARGETS | 53.50% | 5 | WIN |
| WAS@TB | BAKER MAYFIELD UNDER 33.5 PASS ATT | 54.90% | 6 | WIN |
| GB@PHI | JALEN HURTS OVER 67.1 PASS COMP PERCENTAGE | 54.60% | 6 | LOSS |
| LAC@HOU | J.K. DOBBINS ANYTIME TD | 52.80% | 3 | LOSS |
| LAC@HOU | LAC -2.5 | 53.40% | 3 | LOSS |
| LAC@HOU | JUSTIN HERBERT OVER 19.5 RUSH YDS | 53.40% | 5 | LOSS |