Patriots vs 49ers Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 29)

Updated: 2024-09-22T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The New England Patriots travel to face the San Francisco 49ers on September 29, 2024, at Levi’s Stadium. Both teams enter the matchup with 1-2 records and are in desperate need of a win to avoid falling further in their respective divisions.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 29, 2024

Start Time: 4:05 PM EST​

Venue: Levi's Stadium​

49ers Record: (1-2)

Patriots Record: (1-2)

OPENING ODDS

NE Moneyline: +400

SF Moneyline: -543

NE Spread: +10

SF Spread: -10.0

Over/Under: 39.5

NE
Betting Trends

  • The Patriots have struggled against the spread (ATS) this season, going 1-2 overall. They are 4-1 ATS in their last five road games, though they’ve lost six consecutive games against NFC opponents.

SF
Betting Trends

  • The 49ers are 1-2 ATS this season, and they’ve gone 1-7 ATS in their last eight home games, reflecting some inconsistency in covering spreads, especially at Levi’s Stadium.

MATCHUP TRENDS

  • In their last six matchups, the UNDER has hit in five of those games between the Patriots and 49ers, suggesting a trend of lower-scoring affairs when these teams meet.

NE vs. SF
Best Prop Bet

  • Remi's searched hard and found the best Prop Bet for this matchup :Brandon Aiyuk Anytime Touchdown.

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New England vs San Francisco Prediction & Odds:
Free NFL Betting Insights for 9/29/24

The New England Patriots will take on the San Francisco 49ers in a crucial Week 4 matchup at Levi’s Stadium. Both teams come into this game with identical 1-2 records, with the Patriots reeling from a 24-3 loss to the New York Jets, while the 49ers dropped a close contest to the Los Angeles Rams, 27-24.

The Patriots’ offense has been one of the worst in the league, averaging just 13 points per game. Quarterback Jacoby Brissett has struggled behind an underperforming offensive line, and their run game, featuring Rhamondre Stevenson and Antonio Gibson, has failed to get off the ground. New England’s defense, however, remains solid, allowing just 19 points per game. They will need to find a way to contain the 49ers’ balanced attack, especially if they hope to turn their season around. San Francisco, led by Brock Purdy, has been efficient offensively, averaging 24.3 points per game. However, injuries to key players like Christian McCaffrey and George Kittle have hindered their production. Despite the injuries, Jordan Mason has filled in admirably at running back, and the 49ers will look to exploit the Patriots’ vulnerable offensive line with their star pass rusher, Nick Bosa. The 49ers enter as 10-point favorites, and this game could come down to how well their defense handles the Patriots’ struggling offense. Given New England’s difficulties moving the ball and San Francisco’s potent offense, the 49ers will be looking to secure a much-needed home win.

New England Patriots NFL Preview

The New England Patriots are coming off a demoralizing 24-3 loss to the Jets, and they’ll need to quickly fix their offensive woes to avoid falling further in the standings. Jacoby Brissett has struggled under center, completing just 12 of 18 passes for 98 yards in their last outing. The running game, featuring Rhamondre Stevenson, has been underwhelming, and the Patriots’ offensive line has been unable to protect Brissett or open lanes for the rushing attack. Defensively, New England continues to be a bright spot. They rank 10th in points allowed per game, giving up just 19 points per contest. However, the unit will face a tough challenge against a balanced 49ers offense led by Brock Purdy. The Patriots’ secondary will need to limit the deep passes to Jauan Jennings, while their front seven will be tasked with slowing down Jordan Mason on the ground. For the Patriots to stand a chance, they’ll need a much-improved performance from their offense. They have to establish the run early and keep the 49ers’ defense on their heels. If New England can avoid turnovers and control time of possession, they might be able to keep this game closer than expected.

The New England Patriots travel to face the San Francisco 49ers on September 29, 2024, at Levi’s Stadium. Both teams enter the matchup with 1-2 records and are in desperate need of a win to avoid falling further in their respective divisions. New England vs San Francisco AI Prediction: Free NFL Betting Insights for Sep 29. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Francisco 49ers NFL Preview

The San Francisco 49ers enter this game eager to bounce back from a narrow loss to the Rams, which saw them lose a 4th-quarter lead. Brock Purdy has been solid this season, throwing for 842 yards and four touchdowns, but the injuries to key players like Christian McCaffrey and George Kittle have impacted the offense’s ability to close out games. Running back Jordan Mason has stepped in well, rushing for 324 yards, and wide receiver Jauan Jennings has become a reliable target in the passing game. Defensively, the 49ers’ front seven remains one of the strongest in the league, led by Nick Bosa and Fred Warner. They have allowed 104 rushing yards per game, and Bosa will look to disrupt Brissett behind the Patriots’ struggling offensive line. With the Patriots’ offense ranking near the bottom of the league, the 49ers’ defense will aim to dominate the line of scrimmage and force turnovers. At home, the 49ers will be looking to improve their 1-1 record and avoid falling to 1-3, especially in a competitive NFC West division. Their ability to pressure Brissett and control the clock with their ground game will be key to securing a win.

New England vs. San Francisco Prop Picks (AI)

Remi is pouring through tons of data on each line. In fact, anytime the Patriots and 49ers play there’s always several intriguing angles to key in on. Not to mention games played at Levi's Stadium in Sep seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best Prop Bet for this matchup :Brandon Aiyuk Anytime Touchdown.

New England vs. San Francisco Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over tons of data from every past game between the Patriots and 49ers and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.

The Algorithm has been most watching on the linear correlation of emphasis human bettors regularly put on coaching factors between a Patriots team going up against a possibly rested 49ers team. In reality, the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI New England vs San Francisco picks, computer picks Patriots vs 49ers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NFL 10/20 HOU@SEA UNLOCK THIS PICK 5 INTEL Locked INTEL
NFL 10/20 TB@DET UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/20 TB@DET UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/20 TB@DET UNLOCK THIS PICK 1 INTEL Locked INTEL
NFL 10/20 HOU@SEA UNLOCK THIS PICK 0 INTEL Locked INTEL
NFL 10/20 TB@DET UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Patriots Betting Trends

The Patriots have struggled against the spread (ATS) this season, going 1-2 overall. They are 4-1 ATS in their last five road games, though they’ve lost six consecutive games against NFC opponents.

49ers Betting Trends

The 49ers are 1-2 ATS this season, and they’ve gone 1-7 ATS in their last eight home games, reflecting some inconsistency in covering spreads, especially at Levi’s Stadium.

Patriots vs. 49ers Matchup Trends

In their last six matchups, the UNDER has hit in five of those games between the Patriots and 49ers, suggesting a trend of lower-scoring affairs when these teams meet.

New England vs. San Francisco Game Info

New England vs San Francisco starts on September 29, 2024 at 4:05 PM EST.

Spread: San Francisco -10.0
Moneyline: New England +400, San Francisco -543
Over/Under: 39.5

New England: (1-2)  |  San Francisco: (1-2)

Remi's searched hard and found the best Prop Bet for this matchup :Brandon Aiyuk Anytime Touchdown.. Prices move—always shop for the best number.

In their last six matchups, the UNDER has hit in five of those games between the Patriots and 49ers, suggesting a trend of lower-scoring affairs when these teams meet.

NE trend: The Patriots have struggled against the spread (ATS) this season, going 1-2 overall. They are 4-1 ATS in their last five road games, though they’ve lost six consecutive games against NFC opponents.

SF trend: The 49ers are 1-2 ATS this season, and they’ve gone 1-7 ATS in their last eight home games, reflecting some inconsistency in covering spreads, especially at Levi’s Stadium.

See our latest NFL picks and odds pages for 2024 to compare prices before you bet.

New England vs. San Francisco Odds

AI algorithm Remi is pouring through mountains of stats on each team. In fact, anytime the New England vs San Francisco trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable patterns.

New England vs San Francisco Opening Odds

NE Moneyline: +400
SF Moneyline: -543
NE Spread: +10
SF Spread: -10.0
Over/Under: 39.5

New England vs San Francisco Live Odds

Games PTS ML SPR O/U
Oct 23, 2025 8:15PM EDT
Minnesota Vikings
Los Angeles Chargers
10/23/25 8:15PM
Vikings
Chargers
+144
-172
+3 (-105)
-3 (-115)
O 44.5 (-112)
U 44.5 (-108)
Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
+290
-360
+7 (-114)
-7 (-106)
O 40.5 (-105)
U 40.5 (-115)
Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
-430
+340
-7.5 (-110)
+7.5 (-110)
O 46.5 (-105)
U 46.5 (-115)
Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
+245
-300
+6.5 (-110)
-6.5 (-110)
O 43.5 (-115)
U 43.5 (-105)
Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
+265
-330
+6.5 (-106)
-6.5 (-114)
O 50.5 (-105)
U 50.5 (-115)
Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
+270
-335
+7 (-108)
-7 (-112)
O 43.5 (-105)
U 43.5 (-115)
Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
-108
-108
+1.5 (-120)
-1.5 (-102)
O 41.5 (-105)
U 41.5 (-115)
Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
+280
-350
+7.5 (-122)
-7.5 (+100)
O 44.5 (-114)
U 44.5 (-106)
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
-235
+194
-4.5 (-112)
+4.5 (-108)
O 46.5 (-114)
U 46.5 (-106)
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
+146
-174
+3.5 (-118)
-3.5 (-104)
O 49.5 (-120)
U 49.5 (-102)
Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
+750
-1200
+14.5 (-118)
-14.5 (-104)
O 46.5 (-114)
U 46.5 (-106)
Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
-174
+146
-3.5 (-104)
+3.5 (-118)
O 44.5 (-115)
U 44.5 (-105)
Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
+430
-590
+10.5 (-110)
-10.5 (-110)
O 47.5 (-110)
U 47.5 (-110)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers New England Patriots vs. San Francisco 49ers on September 29, 2024 at Levi's Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS
HOU@BAL HOU -125 58.5% 7 WIN
DET@CIN DET -10 55.6% 5 WIN
DAL@NYJ NYJ +1.5 53.7% 3 LOSS
TB@SEA TB +3.5 54.9% 4 WIN
TEN@ARI ARI -7 (BUY 0.5) 54.9% 4 LOSS
DEN@PHI DEN +4.5 57.5% 7 WIN
MIA@CAR TETAIROA MCMILLAN OVER 58.5 RECV YDS 54.5% 4 WIN
LV@IND ASHTON JEANTY UNDER 67.5 RUSH YDS 54.4% 4 WIN
SF@LAR DEMARCUS ROBINSON OVER 29.5 RECV YDS 55.7% 5 WIN
NYJ@MIA NYJ +3 53.8 3 LOSS
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS
TEN@HOU TEN +7.5 57.9% 7 LOSS
LAC@NYG LAC -6 57.3% 7 LOSS
NO@BUF UNDER 48.5 55.1% 3 LOSS
GB@DAL JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS 55.5% 5 LOSS
CAR@NE DRAKE MAYE TO THROW AN INT 56.6% 6 LOSS
SEA@ARI SEA -125 57.7% 6 WIN
SEA@ARI KYLER MURRAY TO THROW AN INT 56.6% 6 WIN
DET@BAL JAHMYR GIBBS OVER 0.5 RUSH TDS 55.8% 5 WIN
DAL@CHI DAL -120 58.7% 6 LOSS
PIT@NE PIT -116 60.1% 6 WIN
ATL@CAR ATL -4.5 55.4% 5 LOSS
LV@WAS LV +3 54.3% 4 LOSS