Patriots vs 49ers Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 29)

Updated: 2024-09-22T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The New England Patriots travel to face the San Francisco 49ers on September 29, 2024, at Levi’s Stadium. Both teams enter the matchup with 1-2 records and are in desperate need of a win to avoid falling further in their respective divisions.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 29, 2024

Start Time: 4:05 PM EST​

Venue: Levi's Stadium​

49ers Record: (1-2)

Patriots Record: (1-2)

OPENING ODDS

NE Moneyline: +400

SF Moneyline: -543

NE Spread: +10

SF Spread: -10.0

Over/Under: 39.5

NE
Betting Trends

  • The Patriots have struggled against the spread (ATS) this season, going 1-2 overall. They are 4-1 ATS in their last five road games, though they’ve lost six consecutive games against NFC opponents.

SF
Betting Trends

  • The 49ers are 1-2 ATS this season, and they’ve gone 1-7 ATS in their last eight home games, reflecting some inconsistency in covering spreads, especially at Levi’s Stadium.

MATCHUP TRENDS

  • In their last six matchups, the UNDER has hit in five of those games between the Patriots and 49ers, suggesting a trend of lower-scoring affairs when these teams meet.

NE vs. SF
Best Prop Bet

  • Remi's searched hard and found the best Prop Bet for this matchup :Brandon Aiyuk Anytime Touchdown.

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New England vs San Francisco Prediction & Odds:
Free NFL Betting Insights for 9/29/24

The New England Patriots will take on the San Francisco 49ers in a crucial Week 4 matchup at Levi’s Stadium. Both teams come into this game with identical 1-2 records, with the Patriots reeling from a 24-3 loss to the New York Jets, while the 49ers dropped a close contest to the Los Angeles Rams, 27-24.

The Patriots’ offense has been one of the worst in the league, averaging just 13 points per game. Quarterback Jacoby Brissett has struggled behind an underperforming offensive line, and their run game, featuring Rhamondre Stevenson and Antonio Gibson, has failed to get off the ground. New England’s defense, however, remains solid, allowing just 19 points per game. They will need to find a way to contain the 49ers’ balanced attack, especially if they hope to turn their season around. San Francisco, led by Brock Purdy, has been efficient offensively, averaging 24.3 points per game. However, injuries to key players like Christian McCaffrey and George Kittle have hindered their production. Despite the injuries, Jordan Mason has filled in admirably at running back, and the 49ers will look to exploit the Patriots’ vulnerable offensive line with their star pass rusher, Nick Bosa. The 49ers enter as 10-point favorites, and this game could come down to how well their defense handles the Patriots’ struggling offense. Given New England’s difficulties moving the ball and San Francisco’s potent offense, the 49ers will be looking to secure a much-needed home win.

New England Patriots NFL Preview

The New England Patriots are coming off a demoralizing 24-3 loss to the Jets, and they’ll need to quickly fix their offensive woes to avoid falling further in the standings. Jacoby Brissett has struggled under center, completing just 12 of 18 passes for 98 yards in their last outing. The running game, featuring Rhamondre Stevenson, has been underwhelming, and the Patriots’ offensive line has been unable to protect Brissett or open lanes for the rushing attack. Defensively, New England continues to be a bright spot. They rank 10th in points allowed per game, giving up just 19 points per contest. However, the unit will face a tough challenge against a balanced 49ers offense led by Brock Purdy. The Patriots’ secondary will need to limit the deep passes to Jauan Jennings, while their front seven will be tasked with slowing down Jordan Mason on the ground. For the Patriots to stand a chance, they’ll need a much-improved performance from their offense. They have to establish the run early and keep the 49ers’ defense on their heels. If New England can avoid turnovers and control time of possession, they might be able to keep this game closer than expected.

The New England Patriots travel to face the San Francisco 49ers on September 29, 2024, at Levi’s Stadium. Both teams enter the matchup with 1-2 records and are in desperate need of a win to avoid falling further in their respective divisions. New England vs San Francisco AI Prediction: Free NFL Betting Insights for Sep 29. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Francisco 49ers NFL Preview

The San Francisco 49ers enter this game eager to bounce back from a narrow loss to the Rams, which saw them lose a 4th-quarter lead. Brock Purdy has been solid this season, throwing for 842 yards and four touchdowns, but the injuries to key players like Christian McCaffrey and George Kittle have impacted the offense’s ability to close out games. Running back Jordan Mason has stepped in well, rushing for 324 yards, and wide receiver Jauan Jennings has become a reliable target in the passing game. Defensively, the 49ers’ front seven remains one of the strongest in the league, led by Nick Bosa and Fred Warner. They have allowed 104 rushing yards per game, and Bosa will look to disrupt Brissett behind the Patriots’ struggling offensive line. With the Patriots’ offense ranking near the bottom of the league, the 49ers’ defense will aim to dominate the line of scrimmage and force turnovers. At home, the 49ers will be looking to improve their 1-1 record and avoid falling to 1-3, especially in a competitive NFC West division. Their ability to pressure Brissett and control the clock with their ground game will be key to securing a win.

New England vs. San Francisco Prop Picks (AI)

Remi is pouring through loads of stats on each line. In fact, anytime the Patriots and 49ers play there’s always several intriguing trends to key in on. Not to mention games played at Levi's Stadium in Sep can often follow normal, predictable patterns.
Remi's searched hard and found the best Prop Bet for this matchup :Brandon Aiyuk Anytime Touchdown.

New England vs. San Francisco Prediction (AI)

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Remi, our AI sports wizard, has been pouring over millions of data from every past game between the Patriots and 49ers and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.

Remi has been most watching on the growing weight knucklehead sportsbettors regularly put on player performance factors between a Patriots team going up against a possibly rested 49ers team. We’ve found the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI New England vs San Francisco picks, computer picks Patriots vs 49ers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NFL 11/10 PHI@GB UNLOCK THIS PICK 6 VAULT v3 Locked VAULT v3
NFL 11/10 PHI@GB UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 11/10 PHI@GB UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 11/10 PHI@GB UNLOCK THIS PICK 1 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Patriots Betting Trends

The Patriots have struggled against the spread (ATS) this season, going 1-2 overall. They are 4-1 ATS in their last five road games, though they’ve lost six consecutive games against NFC opponents.

49ers Betting Trends

The 49ers are 1-2 ATS this season, and they’ve gone 1-7 ATS in their last eight home games, reflecting some inconsistency in covering spreads, especially at Levi’s Stadium.

Patriots vs. 49ers Matchup Trends

In their last six matchups, the UNDER has hit in five of those games between the Patriots and 49ers, suggesting a trend of lower-scoring affairs when these teams meet.

New England vs. San Francisco Game Info

New England vs San Francisco starts on September 29, 2024 at 4:05 PM EST.

Spread: San Francisco -10.0
Moneyline: New England +400, San Francisco -543
Over/Under: 39.5

New England: (1-2)  |  San Francisco: (1-2)

Remi's searched hard and found the best Prop Bet for this matchup :Brandon Aiyuk Anytime Touchdown.. Prices move—always shop for the best number.

In their last six matchups, the UNDER has hit in five of those games between the Patriots and 49ers, suggesting a trend of lower-scoring affairs when these teams meet.

NE trend: The Patriots have struggled against the spread (ATS) this season, going 1-2 overall. They are 4-1 ATS in their last five road games, though they’ve lost six consecutive games against NFC opponents.

SF trend: The 49ers are 1-2 ATS this season, and they’ve gone 1-7 ATS in their last eight home games, reflecting some inconsistency in covering spreads, especially at Levi’s Stadium.

See our latest NFL picks and odds pages for 2024 to compare prices before you bet.

New England vs. San Francisco Odds

Remi is pouring through tons of stats on each player. In fact, anytime the New England vs San Francisco trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps can often follow normal, predictable patterns.

New England vs San Francisco Opening Odds

NE Moneyline: +400
SF Moneyline: -543
NE Spread: +10
SF Spread: -10.0
Over/Under: 39.5

New England vs San Francisco Live Odds

Games PTS ML SPR O/U
Nov 13, 2025 8:15PM EST
New York Jets
New England Patriots
11/13/25 8:15PM
Jets
Patriots
+500
-835
+12 (-114)
-12 (-110)
O 43.5 (-113)
U 43.5 (-113)
Nov 16, 2025 9:30AM EST
Washington Commanders
Miami Dolphins
11/16/25 9:30AM
Commanders
Dolphins
+112
-148
+2.5 (-109)
-2.5 (-117)
O 47 (-117)
U 47 (-109)
Nov 16, 2025 1:00PM EST
Carolina Panthers
Atlanta Falcons
11/16/25 1PM
Panthers
Falcons
+160
-205
+3.5 (-112)
-3.5 (-114)
O 42.5 (-112)
U 42.5 (-114)
Nov 16, 2025 1:00PM EST
Chicago Bears
Minnesota Vikings
11/16/25 1PM
Bears
Vikings
+120
-159
+3 (-115)
-3 (-109)
O 48 (-109)
U 48 (-117)
Nov 16, 2025 1:00PM EST
Los Angeles Chargers
Jacksonville Jaguars
11/16/25 1PM
Chargers
Jaguars
-150
+118
-2.5 (-120)
+2.5 (-106)
O 44 (-112)
U 44 (-114)
Nov 16, 2025 1:00PM EST
Green Bay Packers
New York Giants
11/16/25 1PM
Packers
Giants
-450
+350
-7.5 (-114)
+7.5 (-106)
O 44.5 (-105)
U 44.5 (-115)
Nov 16, 2025 1:00PM EST
Cincinnati Bengals
Pittsburgh Steelers
11/16/25 1PM
Bengals
Steelers
+205
-265
+5.5 (-115)
-5.5 (-110)
O 49.5 (-114)
U 49.5 (-112)
Nov 16, 2025 1:00PM EST
Tampa Bay Buccaneers
Buffalo Bills
11/16/25 1PM
Buccaneers
Bills
+200
-250
+5.5 (-114)
-5.5 (-112)
O 49 (-112)
U 49 (-114)
Nov 16, 2025 1:00PM EST
Houston Texans
Tennessee Titans
11/16/25 1PM
Texans
Titans
-400
+295
-7 (-117)
+7 (-109)
O 39.5 (-109)
U 39.5 (-115)
Nov 16, 2025 4:05PM EST
San Francisco 49ers
Arizona Cardinals
11/16/25 4:05PM
49ers
Cardinals
-159
+118
-3 (-108)
+3 (-118)
O 48.5 (-112)
U 48.5 (-113)
Nov 16, 2025 4:05PM EST
Seattle Seahawks
Los Angeles Rams
11/16/25 4:05PM
Seahawks
Rams
+123
-155
+2.5 (-109)
-2.5 (-117)
O 48 (-113)
U 48 (-113)
Nov 16, 2025 4:25PM EST
Kansas City Chiefs
Denver Broncos
11/16/25 4:25PM
Chiefs
Broncos
-210
+160
-4 (-112)
+4 (-114)
O 44.5 (-110)
U 44.5 (-115)
Nov 16, 2025 4:25PM EST
Baltimore Ravens
Cleveland Browns
11/16/25 4:25PM
Ravens
Browns
-500
+350
-8.5 (-112)
+8.5 (-114)
O 41.5 (-112)
U 41.5 (-113)
Nov 16, 2025 8:20PM EST
Detroit Lions
Philadelphia Eagles
11/16/25 8:20PM
Lions
Eagles
+106
-124
+1.5 (-110)
-1.5 (-110)
O 48.5 (-105)
U 48.5 (-115)
Nov 17, 2025 8:15PM EST
Dallas Cowboys
Las Vegas Raiders
11/17/25 8:15PM
Cowboys
Raiders
-186
+145
-3.5 (-107)
+3.5 (-120)
O 50.5 (-112)
U 50.5 (-114)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers New England Patriots vs. San Francisco 49ers on September 29, 2024 at Levi's Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
LV@DEN RILEY MOSS OVER 4.5 TACKLE + ASST 54.8% 4 WIN
LV@DEN UNDER 43 53.4% 2 WIN
ARI@DAL BUDDA BAKER OVER 7.5 TACKLES + ASSTS 54.4% 4 WIN
ARI@DAL GEORGE PICKENS OVER 4.5 RECEPTIONS 56.6% 6 WIN
DEN@HOU WIL LUTZ OVER 1.5 MADE FIELD GOALS 54.2% 3 LOSS
SEA@WAS SEA -3 56.7% 6 WIN
IND@PIT IND -3 56.8% 6 LOSS
LAC@TEN LAC -9.5 56.2% 6 LOSS
CHI@CIN CHI -2.5 52.6% 2 WIN
SEA@WAS OVER 48 52.9% 2 WIN
SEA@WAS JAYDEN DANIELS OVER 20.5 PASS COMP 56.7% 6 LOSS
JAC@LV JAC -140 64.2% 7 WIN
NO@LAR LAR -14 55.0% 4 WIN
DEN@HOU HOU -1.5 54.2% 3 LOSS
CAR@GB GB -12.5 55.4% 5 LOSS
SF@NYG NYG +2.5 56.1% 5 LOSS
BAL@MIA TUA TAGOVAILOA UNDER 0.5 INT 55.3% 5 LOSS
TB@NO TB -3.5 52.3% 1 WIN
GB@PIT GB -2.5 52.3% 1 WIN
SF@HOU SF +2.5 56.0% 6 LOSS
NYG@PHI NYG +7.5 53.9% 3 LOSS
BUF@CAR CAR +7.5 54.2% 3 LOSS
DAL@DEN DAL +3.5 55.0% 4 LOSS
MIA@ATL MIA +7 54.3% 4 WIN
CLE@NE CLE +7 56.8% 6 LOSS
TB@NO BAKER MAYFIELD OVER 15.5 RUSH YDS 56.6% 6 LOSS
MIN@LAC JUSTIN HERBERT PASS ATT UNDER 35.5 55.5% 5 WIN
TB@DET TB +6.5 54.4% 4 LOSS
TB@DET RACHAAD WHITE UNDER 14.5 RUSH ATT 54.4% 4 WIN
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS