Chiefs vs Chargers Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 29)
Updated: 2024-09-22T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Kansas City Chiefs face the Los Angeles Chargers on September 29, 2024, at SoFi Stadium in an important AFC West matchup. The Chiefs are unbeaten at 3-0, while the Chargers are 2-1 and looking to knock off the reigning Super Bowl champions.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 29, 2024
Start Time: 4:25 PM EST
Venue: SoFi Stadium
Chargers Record: (2-1)
Chiefs Record: (3-0)
OPENING ODDS
KC Moneyline: -397
LAC Moneyline: +316
KC Spread: -8
LAC Spread: +8.0
Over/Under: 39
KC
Betting Trends
- The Chiefs are 2-1 ATS this season and have excelled on the road against the Chargers, going 5-0 straight up in their last five visits to SoFi Stadium.
LAC
Betting Trends
- The Chargers are 1-1 ATS at home this season, but they have struggled overall against the Chiefs, losing five consecutive home games against them. They are also 1-5 ATS in their last six home games.
MATCHUP TRENDS
- The UNDER has hit in 6 of the last 7 games between the Chiefs and AFC West opponents, showing that divisional games have tended to be lower scoring for Kansas City.
KC vs. LAC
Best Prop Bet
- Remi's searched hard and found the best Prop Bet for this matchup: JK Dobbins Over 55.5 Rushing Yards
LIVE NFL ODDS
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Kansas City vs Los Angeles Prediction & Odds:
Free NFL Betting Insights for 9/29/24
On the other side, the Chargers are coming in at 2-1, with Justin Herbert leading an explosive offense that averages 296 passing yards per game. Herbert has thrown for 8 touchdowns in the first three weeks, and his connection with Keenan Allen has been pivotal for the Chargers. However, the Chargers’ defense has struggled at times, allowing 27 points per game, which could be a major concern against Kansas City’s high-powered offense. Kansas City is a 3-point favorite heading into this matchup, and recent history has favored the Chiefs, who have dominated this divisional rivalry in recent years. The Chargers’ pass rush, led by Joey Bosa, will need to step up to disrupt Mahomes and keep the game within reach. A key factor will be the performance of the Chargers’ secondary, which has been vulnerable in big moments.
Felix came in FAST 😤 @fanudike pic.twitter.com/KLNXkBEwVe
— Kansas City Chiefs (@Chiefs) September 24, 2024
Kansas City Chiefs NFL Preview
The Kansas City Chiefs are riding high at 3-0 and look to continue their dominance over the Chargers in Los Angeles. Patrick Mahomes has once again been the driving force behind the Chiefs’ success, leading a passing attack that ranks near the top of the league. Despite some early injuries to key players, Kansas City’s offense has remained highly effective, with Mahomes spreading the ball around to multiple targets. The Chiefs’ defense has quietly been one of the best in the NFL, allowing just 17.3 points per game. Linebacker Nick Bolton and defensive end George Karlaftis have been standout performers, helping the Chiefs stifle opposing offenses. They’ll be tasked with slowing down Herbert and the Chargers’ explosive passing game, which will be a key to securing another road victory. Kansas City’s recent dominance over the Chargers, particularly at SoFi Stadium, gives them a psychological edge heading into this contest. If the Chiefs can maintain their balance on offense and limit Herbert’s opportunities, they should continue their winning streak in Los Angeles.
Credit: USA TODAY/IMAGN
Los Angeles Chargers NFL Preview
The Los Angeles Chargers enter this critical divisional game with a 2-1 record, having shown flashes of brilliance offensively under Justin Herbert. Herbert has been one of the most productive quarterbacks in the league through the first three weeks, but the team is dealing with key injuries, including Joey Bosa and Rashawn Slater, which could significantly impact their ability to handle Kansas City’s potent offense. The Chargers’ offense has excelled in the passing game, with Herbert averaging nearly 300 passing yards per game. Wide receiver Keenan Allen continues to be Herbert’s go-to target, and the Chargers will need Allen to have a big game if they hope to keep pace with Kansas City. Running back Austin Ekeler, returning from injury, will also be key in balancing the offensive attack. Defensively, the Chargers have struggled to stop the run and have been inconsistent in pressuring opposing quarterbacks. If they can’t get pressure on Mahomes, the Chiefs’ offense could have a field day. The Chargers’ secondary, which has allowed multiple big plays this season, will need to be sharp to prevent Mahomes from connecting on deep throws.
consider this ur warning pic.twitter.com/orXUoTrXJ9
— Los Angeles Chargers (@chargers) September 5, 2024
Kansas City vs. Los Angeles Prop Picks (AI)
Kansas City vs. Los Angeles Prediction (AI)
Remi, our AI sports wizard, has been pouring over tons of data from every simulation between the Chiefs and Chargers and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.
Interestingly enough, the data has been most keyed in on the trending factor knucklehead sportsbettors tend to put on Kansas City’s strength factors between a Chiefs team going up against a possibly rested Chargers team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Kansas City vs Los Angeles picks, computer picks Chiefs vs Chargers, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 6 |
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| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 4 |
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| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 4 |
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| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 1 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Chiefs Betting Trends
The Chiefs are 2-1 ATS this season and have excelled on the road against the Chargers, going 5-0 straight up in their last five visits to SoFi Stadium.
Chargers Betting Trends
The Chargers are 1-1 ATS at home this season, but they have struggled overall against the Chiefs, losing five consecutive home games against them. They are also 1-5 ATS in their last six home games.
Chiefs vs. Chargers Matchup Trends
The UNDER has hit in 6 of the last 7 games between the Chiefs and AFC West opponents, showing that divisional games have tended to be lower scoring for Kansas City.
Kansas City vs. Los Angeles Game Info
What time does Kansas City vs Los Angeles start on September 29, 2024?
Kansas City vs Los Angeles starts on September 29, 2024 at 4:25 PM EST.
Where is Kansas City vs Los Angeles being played?
Venue: SoFi Stadium.
What are the opening odds for Kansas City vs Los Angeles?
Spread: Los Angeles +8.0
Moneyline: Kansas City -397, Los Angeles +316
Over/Under: 39
What are the records for Kansas City vs Los Angeles?
Kansas City: (3-0) | Los Angeles: (2-1)
What is the AI best bet for Kansas City vs Los Angeles?
Remi's searched hard and found the best Prop Bet for this matchup: JK Dobbins Over 55.5 Rushing Yards. Prices move—always shop for the best number.
What are Kansas City vs Los Angeles trending bets?
The UNDER has hit in 6 of the last 7 games between the Chiefs and AFC West opponents, showing that divisional games have tended to be lower scoring for Kansas City.
What are Kansas City trending bets?
KC trend: The Chiefs are 2-1 ATS this season and have excelled on the road against the Chargers, going 5-0 straight up in their last five visits to SoFi Stadium.
What are Los Angeles trending bets?
LAC trend: The Chargers are 1-1 ATS at home this season, but they have struggled overall against the Chiefs, losing five consecutive home games against them. They are also 1-5 ATS in their last six home games.
Where can I find AI Picks for Kansas City vs Los Angeles?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
Kansas City vs. Los Angeles Odds
Remi is pouring through tons of stats on each line. In fact, anytime the Kansas City vs Los Angeles trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps can often follow normal, predictable betting trends.
Kansas City vs Los Angeles Opening Odds
KC Moneyline:
-397 LAC Moneyline: +316
KC Spread: -8
LAC Spread: +8.0
Over/Under: 39
Kansas City vs Los Angeles Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
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Nov 13, 2025 8:15PM EST
New York Jets
New England Patriots
11/13/25 8:15PM
Jets
Patriots
|
–
–
|
+534
-750
|
+11.5 (-110)
-11.5 (-110)
|
O 43 (-110)
U 43 (-110)
|
|
|
Nov 16, 2025 9:30AM EST
Washington Commanders
Miami Dolphins
11/16/25 9:30AM
Commanders
Dolphins
|
–
–
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+132
-152
|
+2.5 (+100)
-2.5 (-120)
|
O 47.5 (-112)
U 47.5 (-108)
|
|
|
Nov 16, 2025 1:00PM EST
Carolina Panthers
Atlanta Falcons
11/16/25 1PM
Panthers
Falcons
|
–
–
|
+165
-190
|
+3.5 (-115)
-3.5 (-105)
|
O 42.5 (-110)
U 42.5 (-110)
|
|
|
Nov 16, 2025 1:00PM EST
Chicago Bears
Minnesota Vikings
11/16/25 1PM
Bears
Vikings
|
–
–
|
+142
-162
|
+3 (-110)
-3 (-110)
|
O 49 (-115)
U 49 (-105)
|
|
|
Nov 16, 2025 1:00PM EST
Los Angeles Chargers
Jacksonville Jaguars
11/16/25 1PM
Chargers
Jaguars
|
–
–
|
-150
+130
|
-2.5 (-122)
+2.5 (+102)
|
O 44 (-110)
U 44 (-110)
|
|
|
Nov 16, 2025 1:00PM EST
Green Bay Packers
New York Giants
11/16/25 1PM
Packers
Giants
|
–
–
|
-395
+310
|
-7.5 (-112)
+7.5 (-108)
|
O 44.5 (-105)
U 44.5 (-115)
|
|
|
Nov 16, 2025 1:00PM EST
Cincinnati Bengals
Pittsburgh Steelers
11/16/25 1PM
Bengals
Steelers
|
–
–
|
+200
-240
|
+5.5 (-115)
-5.5 (-105)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
|
Nov 16, 2025 1:00PM EST
Tampa Bay Buccaneers
Buffalo Bills
11/16/25 1PM
Buccaneers
Bills
|
–
–
|
+215
-260
|
+5.5 (-110)
-5.5 (-110)
|
O 49 (-110)
U 49 (-110)
|
|
|
Nov 16, 2025 1:00PM EST
Houston Texans
Tennessee Titans
11/16/25 1PM
Texans
Titans
|
–
–
|
-355
+285
|
-7 (-113)
+7 (-107)
|
O 39 (-116)
U 39 (-104)
|
|
|
Nov 16, 2025 4:05PM EST
San Francisco 49ers
Arizona Cardinals
11/16/25 4:05PM
49ers
Cardinals
|
–
–
|
-140
+120
|
-2.5 (-110)
+2.5 (-110)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
|
Nov 16, 2025 4:05PM EST
Seattle Seahawks
Los Angeles Rams
11/16/25 4:05PM
Seahawks
Rams
|
–
–
|
+130
-150
|
+2.5 (-101)
-2.5 (-119)
|
O 49 (-105)
U 49 (-115)
|
|
|
Nov 16, 2025 4:25PM EST
Kansas City Chiefs
Denver Broncos
11/16/25 4:25PM
Chiefs
Broncos
|
–
–
|
-200
+174
|
-4 (-110)
+4 (-110)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Nov 16, 2025 4:25PM EST
Baltimore Ravens
Cleveland Browns
11/16/25 4:25PM
Ravens
Browns
|
–
–
|
-425
+334
|
-8.5 (-107)
+8.5 (-113)
|
O 40.5 (-120)
U 40.5 (+100)
|
|
|
Nov 16, 2025 8:20PM EST
Detroit Lions
Philadelphia Eagles
11/16/25 8:20PM
Lions
Eagles
|
–
–
|
+102
-122
|
+1.5 (-110)
-1.5 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
|
Nov 17, 2025 8:15PM EST
Dallas Cowboys
Las Vegas Raiders
11/17/25 8:15PM
Cowboys
Raiders
|
–
–
|
-185
+161
|
-3.5 (-110)
+3.5 (-110)
|
O 50 (-110)
U 50 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Kansas City Chiefs vs. Los Angeles Chargers on September 29, 2024 at SoFi Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| LV@DEN | RILEY MOSS OVER 4.5 TACKLE + ASST | 54.8% | 4 | WIN |
| LV@DEN | UNDER 43 | 53.4% | 2 | WIN |
| ARI@DAL | BUDDA BAKER OVER 7.5 TACKLES + ASSTS | 54.4% | 4 | WIN |
| ARI@DAL | GEORGE PICKENS OVER 4.5 RECEPTIONS | 56.6% | 6 | WIN |
| DEN@HOU | WIL LUTZ OVER 1.5 MADE FIELD GOALS | 54.2% | 3 | LOSS |
| SEA@WAS | SEA -3 | 56.7% | 6 | WIN |
| IND@PIT | IND -3 | 56.8% | 6 | LOSS |
| LAC@TEN | LAC -9.5 | 56.2% | 6 | LOSS |
| CHI@CIN | CHI -2.5 | 52.6% | 2 | WIN |
| SEA@WAS | OVER 48 | 52.9% | 2 | WIN |
| SEA@WAS | JAYDEN DANIELS OVER 20.5 PASS COMP | 56.7% | 6 | LOSS |
| JAC@LV | JAC -140 | 64.2% | 7 | WIN |
| NO@LAR | LAR -14 | 55.0% | 4 | WIN |
| DEN@HOU | HOU -1.5 | 54.2% | 3 | LOSS |
| CAR@GB | GB -12.5 | 55.4% | 5 | LOSS |
| SF@NYG | NYG +2.5 | 56.1% | 5 | LOSS |
| BAL@MIA | TUA TAGOVAILOA UNDER 0.5 INT | 55.3% | 5 | LOSS |
| TB@NO | TB -3.5 | 52.3% | 1 | WIN |
| GB@PIT | GB -2.5 | 52.3% | 1 | WIN |
| SF@HOU | SF +2.5 | 56.0% | 6 | LOSS |
| NYG@PHI | NYG +7.5 | 53.9% | 3 | LOSS |
| BUF@CAR | CAR +7.5 | 54.2% | 3 | LOSS |
| DAL@DEN | DAL +3.5 | 55.0% | 4 | LOSS |
| MIA@ATL | MIA +7 | 54.3% | 4 | WIN |
| CLE@NE | CLE +7 | 56.8% | 6 | LOSS |
| TB@NO | BAKER MAYFIELD OVER 15.5 RUSH YDS | 56.6% | 6 | LOSS |
| MIN@LAC | JUSTIN HERBERT PASS ATT UNDER 35.5 | 55.5% | 5 | WIN |
| TB@DET | TB +6.5 | 54.4% | 4 | LOSS |
| TB@DET | RACHAAD WHITE UNDER 14.5 RUSH ATT | 54.4% | 4 | WIN |
| NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
| CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
| PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
| GB@ARI | ARI +7 | 54.8% | 5 | WIN |
| NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
| WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
| GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
| PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
| BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
| CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
| TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
| DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
| SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
| LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
| ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
| TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
| LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
| SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
| CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
| DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
| KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
| KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |