Chiefs vs Chargers Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 29)
Updated: 2024-09-22T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Kansas City Chiefs face the Los Angeles Chargers on September 29, 2024, at SoFi Stadium in an important AFC West matchup. The Chiefs are unbeaten at 3-0, while the Chargers are 2-1 and looking to knock off the reigning Super Bowl champions.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 29, 2024
Start Time: 4:25 PM EST
Venue: SoFi Stadium
Chargers Record: (2-1)
Chiefs Record: (3-0)
OPENING ODDS
KC Moneyline: -397
LAC Moneyline: +316
KC Spread: -8
LAC Spread: +8.0
Over/Under: 39
KC
Betting Trends
- The Chiefs are 2-1 ATS this season and have excelled on the road against the Chargers, going 5-0 straight up in their last five visits to SoFi Stadium.
LAC
Betting Trends
- The Chargers are 1-1 ATS at home this season, but they have struggled overall against the Chiefs, losing five consecutive home games against them. They are also 1-5 ATS in their last six home games.
MATCHUP TRENDS
- The UNDER has hit in 6 of the last 7 games between the Chiefs and AFC West opponents, showing that divisional games have tended to be lower scoring for Kansas City.
KC vs. LAC
Best Prop Bet
- Remi's searched hard and found the best Prop Bet for this matchup: JK Dobbins Over 55.5 Rushing Yards
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Kansas City vs Los Angeles Prediction & Odds:
Free NFL Betting Insights for 9/29/24
On the other side, the Chargers are coming in at 2-1, with Justin Herbert leading an explosive offense that averages 296 passing yards per game. Herbert has thrown for 8 touchdowns in the first three weeks, and his connection with Keenan Allen has been pivotal for the Chargers. However, the Chargers’ defense has struggled at times, allowing 27 points per game, which could be a major concern against Kansas City’s high-powered offense. Kansas City is a 3-point favorite heading into this matchup, and recent history has favored the Chiefs, who have dominated this divisional rivalry in recent years. The Chargers’ pass rush, led by Joey Bosa, will need to step up to disrupt Mahomes and keep the game within reach. A key factor will be the performance of the Chargers’ secondary, which has been vulnerable in big moments.
Felix came in FAST 😤 @fanudike pic.twitter.com/KLNXkBEwVe
— Kansas City Chiefs (@Chiefs) September 24, 2024
Kansas City Chiefs NFL Preview
The Kansas City Chiefs are riding high at 3-0 and look to continue their dominance over the Chargers in Los Angeles. Patrick Mahomes has once again been the driving force behind the Chiefs’ success, leading a passing attack that ranks near the top of the league. Despite some early injuries to key players, Kansas City’s offense has remained highly effective, with Mahomes spreading the ball around to multiple targets. The Chiefs’ defense has quietly been one of the best in the NFL, allowing just 17.3 points per game. Linebacker Nick Bolton and defensive end George Karlaftis have been standout performers, helping the Chiefs stifle opposing offenses. They’ll be tasked with slowing down Herbert and the Chargers’ explosive passing game, which will be a key to securing another road victory. Kansas City’s recent dominance over the Chargers, particularly at SoFi Stadium, gives them a psychological edge heading into this contest. If the Chiefs can maintain their balance on offense and limit Herbert’s opportunities, they should continue their winning streak in Los Angeles.
Credit: USA TODAY/IMAGN
Los Angeles Chargers NFL Preview
The Los Angeles Chargers enter this critical divisional game with a 2-1 record, having shown flashes of brilliance offensively under Justin Herbert. Herbert has been one of the most productive quarterbacks in the league through the first three weeks, but the team is dealing with key injuries, including Joey Bosa and Rashawn Slater, which could significantly impact their ability to handle Kansas City’s potent offense. The Chargers’ offense has excelled in the passing game, with Herbert averaging nearly 300 passing yards per game. Wide receiver Keenan Allen continues to be Herbert’s go-to target, and the Chargers will need Allen to have a big game if they hope to keep pace with Kansas City. Running back Austin Ekeler, returning from injury, will also be key in balancing the offensive attack. Defensively, the Chargers have struggled to stop the run and have been inconsistent in pressuring opposing quarterbacks. If they can’t get pressure on Mahomes, the Chiefs’ offense could have a field day. The Chargers’ secondary, which has allowed multiple big plays this season, will need to be sharp to prevent Mahomes from connecting on deep throws.
consider this ur warning pic.twitter.com/orXUoTrXJ9
— Los Angeles Chargers (@chargers) September 5, 2024
Kansas City vs. Los Angeles Prop Picks (AI)
Kansas City vs. Los Angeles Prediction (AI)
Remi, our AI sports algorithm, has been pouring over millions of data from every simulation between the Chiefs and Chargers and using recursive machine learning and impressive AI to analyze the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most fixated on the linear correlation of weight knucklehead sportsbettors regularly put on player performance factors between a Chiefs team going up against a possibly strong Chargers team. Trends look to say the true game analytics might reflect a moderate lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Kansas City vs Los Angeles picks, computer picks Chiefs vs Chargers, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 5 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 1 |
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| NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 0 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Chiefs Betting Trends
The Chiefs are 2-1 ATS this season and have excelled on the road against the Chargers, going 5-0 straight up in their last five visits to SoFi Stadium.
Chargers Betting Trends
The Chargers are 1-1 ATS at home this season, but they have struggled overall against the Chiefs, losing five consecutive home games against them. They are also 1-5 ATS in their last six home games.
Chiefs vs. Chargers Matchup Trends
The UNDER has hit in 6 of the last 7 games between the Chiefs and AFC West opponents, showing that divisional games have tended to be lower scoring for Kansas City.
Kansas City vs. Los Angeles Game Info
What time does Kansas City vs Los Angeles start on September 29, 2024?
Kansas City vs Los Angeles starts on September 29, 2024 at 4:25 PM EST.
Where is Kansas City vs Los Angeles being played?
Venue: SoFi Stadium.
What are the opening odds for Kansas City vs Los Angeles?
Spread: Los Angeles +8.0
Moneyline: Kansas City -397, Los Angeles +316
Over/Under: 39
What are the records for Kansas City vs Los Angeles?
Kansas City: (3-0) | Los Angeles: (2-1)
What is the AI best bet for Kansas City vs Los Angeles?
Remi's searched hard and found the best Prop Bet for this matchup: JK Dobbins Over 55.5 Rushing Yards. Prices move—always shop for the best number.
What are Kansas City vs Los Angeles trending bets?
The UNDER has hit in 6 of the last 7 games between the Chiefs and AFC West opponents, showing that divisional games have tended to be lower scoring for Kansas City.
What are Kansas City trending bets?
KC trend: The Chiefs are 2-1 ATS this season and have excelled on the road against the Chargers, going 5-0 straight up in their last five visits to SoFi Stadium.
What are Los Angeles trending bets?
LAC trend: The Chargers are 1-1 ATS at home this season, but they have struggled overall against the Chiefs, losing five consecutive home games against them. They are also 1-5 ATS in their last six home games.
Where can I find AI Picks for Kansas City vs Los Angeles?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
Kansas City vs. Los Angeles Odds
Remi is pouring through mountains of data points on each line. In fact, anytime the Kansas City vs Los Angeles trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable betting trends.
Kansas City vs Los Angeles Opening Odds
KC Moneyline:
-397 LAC Moneyline: +316
KC Spread: -8
LAC Spread: +8.0
Over/Under: 39
Kansas City vs Los Angeles Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Oct 23, 2025 8:15PM EDT
Minnesota Vikings
Los Angeles Chargers
10/23/25 8:15PM
Vikings
Chargers
|
–
–
|
+144
-172
|
+3 (-105)
-3 (-115)
|
O 44.5 (-112)
U 44.5 (-108)
|
|
|
Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
|
–
–
|
+290
-360
|
+7 (-114)
-7 (-106)
|
O 40.5 (-105)
U 40.5 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
|
–
–
|
-430
+340
|
-7.5 (-110)
+7.5 (-110)
|
O 46.5 (-105)
U 46.5 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
|
–
–
|
+245
-300
|
+6.5 (-110)
-6.5 (-110)
|
O 43.5 (-115)
U 43.5 (-105)
|
|
|
Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
|
–
–
|
+265
-330
|
+6.5 (-106)
-6.5 (-114)
|
O 50.5 (-105)
U 50.5 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
|
–
–
|
+270
-335
|
+7 (-108)
-7 (-112)
|
O 43.5 (-105)
U 43.5 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
|
–
–
|
-108
-108
|
+1.5 (-120)
-1.5 (-102)
|
O 41.5 (-105)
U 41.5 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
|
–
–
|
+280
-350
|
+7.5 (-122)
-7.5 (+100)
|
O 44.5 (-114)
U 44.5 (-106)
|
|
|
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
|
–
–
|
-235
+194
|
-4.5 (-112)
+4.5 (-108)
|
O 46.5 (-114)
U 46.5 (-106)
|
|
|
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
|
–
–
|
+146
-174
|
+3.5 (-118)
-3.5 (-104)
|
O 49.5 (-120)
U 49.5 (-102)
|
|
|
Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
|
–
–
|
+750
-1200
|
+14.5 (-118)
-14.5 (-104)
|
O 46.5 (-114)
U 46.5 (-106)
|
|
|
Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
|
–
–
|
-174
+146
|
-3.5 (-104)
+3.5 (-118)
|
O 44.5 (-115)
U 44.5 (-105)
|
|
|
Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
|
–
–
|
+430
-590
|
+10.5 (-110)
-10.5 (-110)
|
O 47.5 (-110)
U 47.5 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Kansas City Chiefs vs. Los Angeles Chargers on September 29, 2024 at SoFi Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
| CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
| PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
| GB@ARI | ARI +7 | 54.8% | 5 | WIN |
| NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
| WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
| GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
| PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
| BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
| CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
| TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
| DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
| SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
| LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
| ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
| TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
| LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
| SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
| CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
| DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
| KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
| KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
| HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
| DET@CIN | DET -10 | 55.6% | 5 | WIN |
| DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
| TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
| TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
| DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
| MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
| LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
| SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
| NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
| CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
| NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
| CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
| NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
| CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
| WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
| BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
| TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
| LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
| NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
| GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
| CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |