Jaguars vs Bills Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 23)
Updated: 2024-09-16T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Jacksonville Jaguars will face the Buffalo Bills on September 23, 2024, at Highmark Stadium for a primetime Monday Night Football showdown. The Bills, entering the game as 5.5-point favorites, will look to maintain their early momentum after starting 2-0, while the Jaguars will attempt to recover from a rocky 1-1 start.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 23, 2024
Start Time: 7:30 PM EST
Venue: Highmark Stadium
Bills Record: (2-0)
Jaguars Record: (0-2)
OPENING ODDS
JAC Moneyline: +199
BUF Moneyline: -244
JAC Spread: +5.5
BUF Spread: -5.5
Over/Under: 45.5
JAC
Betting Trends
- The Jaguars are 1-1 against the spread (ATS) this season and have struggled with consistency. However, Jacksonville has historically performed better as underdogs, having covered in five of their last seven games when listed as underdogs of more than 4 points.
BUF
Betting Trends
- The Bills are 1-0-1 ATS this season and are generally dominant at home. They’ve covered the spread in five of their last seven home games, particularly when facing non-division opponents.
MATCHUP TRENDS
- Games involving the Jaguars have yet to go over the total points line in 2024, and the Bills have seen only one game hit the over so far this season. With the over/under set at 46.5 points, and given the Bills’ strong defense and Jacksonville’s offensive struggles, the under could be a trend to watch.
JAC vs. BUF
Best Prop Bet
- Remi's searched hard and crunched the numbers and found the best prop bet play for this game: QB Trevor Lawrence Over 228.5 Passing Yards
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Jacksonville vs Buffalo Prediction & Odds:
Free NFL Betting Insights for 9/23/24
Jacksonville’s ground game, led by Travis Etienne, has shown flashes, but the team has yet to establish the consistent offensive rhythm needed to challenge an elite defense like Buffalo’s. Defensively, the Bills have been rock solid, particularly against the pass. Buffalo’s pass rush has been effective, forcing turnovers and putting pressure on opposing quarterbacks. For Jacksonville, their defense will need to step up, especially against Buffalo’s balanced offensive approach. If the Jaguars can’t control the line of scrimmage and slow down Buffalo’s offense, they will have difficulty keeping pace. This game could be decided by whether Jacksonville can limit their mistakes and capitalize on their red zone opportunities. The Bills, meanwhile, will look to dominate through their defense and maintain offensive efficiency to secure a 3-0 start to the season.
Join us at The Bank for MNF ‼️@EverBankStadium | @UF
— Jacksonville Jaguars (@Jaguars) September 17, 2024
Jacksonville Jaguars NFL Preview
The Jacksonville Jaguars head into their Monday Night Football clash with the Buffalo Bills needing a rebound after a mixed start to the 2024 season. At 1-1, Jacksonville has shown promise at times but has been plagued by offensive inefficiency and inconsistent play from quarterback Trevor Lawrence. Lawrence has thrown for 436 yards and three touchdowns through two games, but his completion percentage has been subpar, and the Jaguars have struggled to finish drives, especially in the red zone. Travis Etienne has been a bright spot, averaging 5.9 yards per carry and providing a spark in the run game, but Jacksonville will need more balance if they hope to compete with Buffalo. The Jaguars’ defense has allowed 22.5 points per game, and while they have been solid against the run, their secondary has been vulnerable to big plays, which could be a problem against Buffalo’s tall, athletic receivers. For the Jaguars to pull off the upset, they will need a near-perfect performance from Lawrence, combined with a strong showing from their defense. Limiting Josh Allen’s ability to make big plays and controlling the tempo with their ground game will be crucial to Jacksonville’s success.
Credit: USA TODAY/IMAGN
Buffalo Bills NFL Preview
The Buffalo Bills enter Week 3 with confidence after a dominant start to the 2024 season, sitting at 2-0 and looking like one of the top teams in the AFC. Quarterback Josh Allen has been in fine form, throwing for 518 yards and five touchdowns through two games, with minimal turnovers. The Bills’ revamped receiving corps, featuring taller targets such as Dalton Kincaid and Dawson Knox, has provided Allen with plenty of red zone options, making Buffalo’s offense especially difficult to stop near the goal line. On the defensive side of the ball, Buffalo has been equally impressive, allowing just 15.5 points per game and ranking near the top of the league in both takeaways and third-down defense. Their ability to pressure quarterbacks and cover receivers tightly has stifled opponents, which could spell trouble for a Jaguars team that has struggled to find offensive consistency. If the Bills’ defense can force Trevor Lawrence into uncomfortable situations and limit the impact of Jacksonville’s run game, they should be well-positioned to extend their winning streak. Buffalo’s path to victory will involve maintaining their aggressive play on both sides of the ball, and controlling the clock by sustaining long, methodical drives will be key to wearing down Jacksonville’s defense.
BILLS WIN!!!!#BUFvsMIA | #BillsMafia pic.twitter.com/HrAjLGA66e
— Buffalo Bills (@BuffaloBills) September 13, 2024
Jacksonville vs. Buffalo Prop Picks (AI)
Jacksonville vs. Buffalo Prediction (AI)
Remi, our AI sports algorithm, has been pouring over mountains of data from every angle between the Jaguars and Bills and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.
Interestingly enough, the data has been most focused on the growing factor emotional bettors tend to put on Jacksonville’s strength factors between a Jaguars team going up against a possibly deflated Bills team. It appears the true game analytics appear to reflect a strong lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Jacksonville vs Buffalo picks, computer picks Jaguars vs Bills, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 5 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 1 |
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| NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 0 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Jaguars Betting Trends
The Jaguars are 1-1 against the spread (ATS) this season and have struggled with consistency. However, Jacksonville has historically performed better as underdogs, having covered in five of their last seven games when listed as underdogs of more than 4 points.
Bills Betting Trends
The Bills are 1-0-1 ATS this season and are generally dominant at home. They’ve covered the spread in five of their last seven home games, particularly when facing non-division opponents.
Jaguars vs. Bills Matchup Trends
Games involving the Jaguars have yet to go over the total points line in 2024, and the Bills have seen only one game hit the over so far this season. With the over/under set at 46.5 points, and given the Bills’ strong defense and Jacksonville’s offensive struggles, the under could be a trend to watch.
Jacksonville vs. Buffalo Game Info
What time does Jacksonville vs Buffalo start on September 23, 2024?
Jacksonville vs Buffalo starts on September 23, 2024 at 7:30 PM EST.
Where is Jacksonville vs Buffalo being played?
Venue: Highmark Stadium.
What are the opening odds for Jacksonville vs Buffalo?
Spread: Buffalo -5.5
Moneyline: Jacksonville +199, Buffalo -244
Over/Under: 45.5
What are the records for Jacksonville vs Buffalo?
Jacksonville: (0-2) | Buffalo: (2-0)
What is the AI best bet for Jacksonville vs Buffalo?
Remi's searched hard and crunched the numbers and found the best prop bet play for this game: QB Trevor Lawrence Over 228.5 Passing Yards. Prices move—always shop for the best number.
What are Jacksonville vs Buffalo trending bets?
Games involving the Jaguars have yet to go over the total points line in 2024, and the Bills have seen only one game hit the over so far this season. With the over/under set at 46.5 points, and given the Bills’ strong defense and Jacksonville’s offensive struggles, the under could be a trend to watch.
What are Jacksonville trending bets?
JAC trend: The Jaguars are 1-1 against the spread (ATS) this season and have struggled with consistency. However, Jacksonville has historically performed better as underdogs, having covered in five of their last seven games when listed as underdogs of more than 4 points.
What are Buffalo trending bets?
BUF trend: The Bills are 1-0-1 ATS this season and are generally dominant at home. They’ve covered the spread in five of their last seven home games, particularly when facing non-division opponents.
Where can I find AI Picks for Jacksonville vs Buffalo?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
Jacksonville vs. Buffalo Odds
AI algorithm Remi is pouring through tons of data points on each team. In fact, anytime the Jacksonville vs Buffalo trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude can often follow normal, predictable betting trends.
Jacksonville vs Buffalo Opening Odds
JAC Moneyline:
+199 BUF Moneyline: -244
JAC Spread: +5.5
BUF Spread: -5.5
Over/Under: 45.5
Jacksonville vs Buffalo Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
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Minnesota Vikings
Los Angeles Chargers
10/23/25 8:15PM
Vikings
Chargers
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–
–
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+142
-165
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+3 (-110)
-3 (-110)
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O 45 (-110)
U 45 (-110)
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10/26/25 1PM
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Patriots
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–
–
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+290
-360
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+7 (-110)
-7 (-110)
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O 40.5 (-110)
U 40.5 (-110)
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Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
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Bills
Panthers
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–
–
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-400
+320
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-7.5 (-110)
+7.5 (-110)
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O 45.5 (-110)
U 45.5 (-110)
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Oct 26, 2025 1:00PM EDT
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Jets
Bengals
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–
–
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+250
-300
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+6.5 (-105)
-6.5 (-115)
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O 44.5 (-105)
U 44.5 (-115)
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Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
|
–
–
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+265
-325
|
+7 (-120)
-7 (+100)
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O 50 (-110)
U 50 (-110)
|
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Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
|
–
–
|
+290
-360
|
+7 (-105)
-7 (-115)
|
O 43.5 (-115)
U 43.5 (-105)
|
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Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
|
–
–
|
-110
-106
|
-1.5 (-104)
+1.5 (-118)
|
O 41.5 (-115)
U 41.5 (-105)
|
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Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
|
–
–
|
+280
-350
|
+7 (-110)
-7 (-110)
|
O 44.5 (-110)
U 44.5 (-110)
|
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|
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
|
–
–
|
-220
+184
|
-4.5 (-112)
+4.5 (-108)
|
O 47.5 (-105)
U 47.5 (-115)
|
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|
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
|
–
–
|
+146
-170
|
+3 (+100)
-3 (-120)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
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Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
|
–
–
|
+750
-1200
|
+14 (-110)
-14 (-110)
|
O 47 (-110)
U 47 (-110)
|
|
|
Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
|
–
–
|
-185
+159
|
-3.5 (-105)
+3.5 (-115)
|
O 45 (-113)
U 45 (-107)
|
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Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
|
–
–
|
+465
-630
|
+10.5 (-115)
-10.5 (-105)
|
O 48.5 (-110)
U 48.5 (-110)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Jacksonville Jaguars vs. Buffalo Bills on September 23, 2024 at Highmark Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
| CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
| PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
| GB@ARI | ARI +7 | 54.8% | 5 | WIN |
| NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
| WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
| GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
| PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
| BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
| CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
| TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
| DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
| SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
| LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
| ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
| TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
| LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
| SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
| CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
| DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
| KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
| KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
| HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
| DET@CIN | DET -10 | 55.6% | 5 | WIN |
| DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
| TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
| TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
| DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
| MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
| LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
| SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
| NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
| CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
| NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
| CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
| NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
| CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
| WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
| BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
| TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
| LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
| NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
| GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
| CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |