49ers vs Rams Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 22)
Updated: 2024-09-15T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The San Francisco 49ers face the Los Angeles Rams on September 22, 2024, at SoFi Stadium. The 49ers, coming off a 1-1 start, are the favorites in this NFC West clash, while the Rams seek their first win after a challenging 0-2 start.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 22, 2024
Start Time: 4:25 PM EST
Venue: SoFi Stadium
Rams Record: (0-2)
49ers Record: (1-1)
OPENING ODDS
SF Moneyline: -353
LAR Moneyline: +281
SF Spread: -7.5
LAR Spread: +7.5
Over/Under: 43
SF
Betting Trends
- The 49ers are 1-1 ATS this season and have covered the spread in six of their last seven games as road favorites. Historically, they’ve performed well against NFC West opponents, having won 11 of the last 12 games against the Rams.
LAR
Betting Trends
- The Rams are 0-2 ATS in 2024 and have struggled to cover in home games recently, especially as underdogs. They’ve failed to cover in five of their last six games as home underdogs against teams with a winning record.
MATCHUP TRENDS
- The Rams have gone under the total points line in five of their last six games at home when facing NFC West opponents. Meanwhile, the 49ers have hit the over in five of their last seven road games, making the total points line of 43.5 something to monitor in this matchup.
SF vs. LAR
Best Prop Bet
- Remi's searched hard and crunched the numbers and found the best prop bet play for this game: RB Jordan Mason to score a TOUCHDOWN
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San Francisco vs Los Angeles Rams Prediction & Odds:
Free NFL Betting Insights for 9/22/24
Quarterback Matthew Stafford threw for 216 yards, but the team’s lack of a consistent ground attack, with Blake Corum leading the way with just 28 yards, has hampered their ability to keep up with opponents. Defensively, the Rams will need a major turnaround to contain San Francisco’s multifaceted offensive attack, especially as they struggle to generate pressure on opposing quarterbacks. This game will likely be decided by San Francisco’s ability to exploit the Rams’ defensive struggles. The 49ers will aim to maintain their balanced offensive attack while leaning on a strong run game to control possession. Meanwhile, the Rams will need Stafford to connect with key targets like Demarcus Robinson to have any hope of keeping pace with a 49ers team that has dominated this rivalry in recent seasons.
Grave Digger on the mic 🎤
— San Francisco 49ers (@49ers) September 18, 2024
Mic'd Up powered by @Cisco pic.twitter.com/UtWLtBR1Xc
San Francisco 49ers NFL Preview
The San Francisco 49ers head into Week 3 looking to bounce back from a narrow 23-17 loss to the Minnesota Vikings. At 1-1, the 49ers remain one of the more balanced teams in the NFL. Quarterback Brock Purdy has shown composure, throwing for 519 yards and two touchdowns over two games. His ability to spread the ball to key playmakers like Deebo Samuel and Brandon Aiyuk has been critical to San Francisco’s offensive success. The 49ers’ rushing attack has been just as effective, averaging 141 yards per game, with Jordan Mason emerging as the lead back. The combination of a strong run game and efficient passing attack allows the 49ers to control the pace of the game, something they will look to do against a Rams defense that has struggled mightily. San Francisco’s defense, which ranks in the middle of the pack in terms of yards allowed, will also look to pressure Matthew Stafford and force him into mistakes. San Francisco’s game plan will revolve around their ability to exploit the Rams’ defensive weaknesses. If they can continue their balanced offensive approach and limit turnovers, the 49ers are in a strong position to earn their second win of the season.
Credit: USA TODAY/IMAGN
Los Angeles Rams Rams NFL Preview
The Los Angeles Rams are in a precarious position heading into their Week 3 matchup against the San Francisco 49ers. With an 0-2 start, the Rams’ season has been defined by struggles on both sides of the ball. In their latest outing, they were dismantled by the Arizona Cardinals 41-10. Quarterback Matthew Stafford has been effective at times, throwing for 432 yards across two games, but he has struggled to find consistency without a reliable running game. Blake Corum, their lead back, has been unable to gain much traction, putting added pressure on Stafford and the passing attack to carry the offense. Defensively, the Rams have been porous, allowing 30.5 points per game. The secondary has struggled to contain opposing wide receivers, and the lack of a consistent pass rush has left the defense vulnerable to big plays. For the Rams to compete with San Francisco, their defense will need to find ways to disrupt Brock Purdy’s rhythm and limit the effectiveness of the 49ers’ ground game. A key focus will be on limiting explosive plays from versatile threats like Deebo Samuel and George Kittle. The Rams have also been prone to turnovers, an area they must clean up to keep this game competitive. If they can limit mistakes and find a way to establish a balanced offensive attack, they might be able to hang with a formidable 49ers team. Otherwise, the Rams risk falling to 0-3 in what has been a difficult start to their season.
LA Rams Roster Moves:
— Los Angeles Rams (@RamsNFL) September 17, 2024
• Terminated (by Club) from Practice Squad OL Ty Nsekhepic.twitter.com/eNyMjVqkFF
San Francisco vs. Los Angeles Rams Prop Picks (AI)
San Francisco vs. Los Angeles Rams Prediction (AI)
Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every past game between the 49ers and Rams and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most fixated on the trending emphasis knucklehead sportsbettors often put on San Francisco’s strength factors between a 49ers team going up against a possibly healthy Rams team. We’ve found the true game analytics might reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI San Francisco vs Los Angeles Rams picks, computer picks 49ers vs Rams, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 6 |
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| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 4 |
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| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 4 |
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| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 1 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
49ers Betting Trends
The 49ers are 1-1 ATS this season and have covered the spread in six of their last seven games as road favorites. Historically, they’ve performed well against NFC West opponents, having won 11 of the last 12 games against the Rams.
Rams Betting Trends
The Rams are 0-2 ATS in 2024 and have struggled to cover in home games recently, especially as underdogs. They’ve failed to cover in five of their last six games as home underdogs against teams with a winning record.
49ers vs. Rams Matchup Trends
The Rams have gone under the total points line in five of their last six games at home when facing NFC West opponents. Meanwhile, the 49ers have hit the over in five of their last seven road games, making the total points line of 43.5 something to monitor in this matchup.
San Francisco vs. Los Angeles Rams Game Info
What time does San Francisco vs Los Angeles Rams start on September 22, 2024?
San Francisco vs Los Angeles Rams starts on September 22, 2024 at 4:25 PM EST.
Where is San Francisco vs Los Angeles Rams being played?
Venue: SoFi Stadium.
What are the opening odds for San Francisco vs Los Angeles Rams?
Spread: Los Angeles Rams +7.5
Moneyline: San Francisco -353, Los Angeles Rams +281
Over/Under: 43
What are the records for San Francisco vs Los Angeles Rams?
San Francisco: (1-1) | Los Angeles Rams: (0-2)
What is the AI best bet for San Francisco vs Los Angeles Rams?
Remi's searched hard and crunched the numbers and found the best prop bet play for this game: RB Jordan Mason to score a TOUCHDOWN. Prices move—always shop for the best number.
What are San Francisco vs Los Angeles Rams trending bets?
The Rams have gone under the total points line in five of their last six games at home when facing NFC West opponents. Meanwhile, the 49ers have hit the over in five of their last seven road games, making the total points line of 43.5 something to monitor in this matchup.
What are San Francisco trending bets?
SF trend: The 49ers are 1-1 ATS this season and have covered the spread in six of their last seven games as road favorites. Historically, they’ve performed well against NFC West opponents, having won 11 of the last 12 games against the Rams.
What are Los Angeles Rams trending bets?
LAR trend: The Rams are 0-2 ATS in 2024 and have struggled to cover in home games recently, especially as underdogs. They’ve failed to cover in five of their last six games as home underdogs against teams with a winning record.
Where can I find AI Picks for San Francisco vs Los Angeles Rams?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
San Francisco vs. Los Angeles Rams Odds
AI algorithm Remi is pouring through tons of data points on each team. In fact, anytime the San Francisco vs Los Angeles Rams trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps rarely follow normal, predictable patterns.
San Francisco vs Los Angeles Rams Opening Odds
SF Moneyline:
-353 LAR Moneyline: +281
SF Spread: -7.5
LAR Spread: +7.5
Over/Under: 43
San Francisco vs Los Angeles Rams Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Nov 13, 2025 8:15PM EST
New York Jets
New England Patriots
11/13/25 8:15PM
Jets
Patriots
|
–
–
|
+525
-800
|
+11.5 (-105)
-11.5 (-115)
|
O 43 (-110)
U 43 (-110)
|
|
|
Nov 16, 2025 9:30AM EST
Washington Commanders
Miami Dolphins
11/16/25 9:30AM
Commanders
Dolphins
|
–
–
|
+135
-160
|
+3 (-110)
-3 (-110)
|
O 47.5 (-115)
U 47.5 (-105)
|
|
|
Nov 16, 2025 1:00PM EST
Carolina Panthers
Atlanta Falcons
11/16/25 1PM
Panthers
Falcons
|
–
–
|
+160
-185
|
+3.5 (-115)
-3.5 (-105)
|
O 42.5 (-110)
U 42.5 (-110)
|
|
|
Nov 16, 2025 1:00PM EST
Chicago Bears
Minnesota Vikings
11/16/25 1PM
Bears
Vikings
|
–
–
|
+150
-175
|
+3 (-105)
-3 (-115)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
|
Nov 16, 2025 1:00PM EST
Los Angeles Chargers
Jacksonville Jaguars
11/16/25 1PM
Chargers
Jaguars
|
–
–
|
-165
+140
|
-3 (-105)
+3 (-115)
|
O 44 (-110)
U 44 (-110)
|
|
|
Nov 16, 2025 1:00PM EST
Green Bay Packers
New York Giants
11/16/25 1PM
Packers
Giants
|
–
–
|
-450
+350
|
-7.5 (-114)
+7.5 (-106)
|
O 44.5 (-105)
U 44.5 (-115)
|
|
|
Nov 16, 2025 1:00PM EST
Cincinnati Bengals
Pittsburgh Steelers
11/16/25 1PM
Bengals
Steelers
|
–
–
|
+205
-245
|
+5.5 (-110)
-5.5 (-110)
|
O 49.5 (-105)
U 49.5 (-115)
|
|
|
Nov 16, 2025 1:00PM EST
Tampa Bay Buccaneers
Buffalo Bills
11/16/25 1PM
Buccaneers
Bills
|
–
–
|
+225
-275
|
+5.5 (-110)
-5.5 (-110)
|
O 49 (-110)
U 49 (-110)
|
|
|
Nov 16, 2025 1:00PM EST
Houston Texans
Tennessee Titans
11/16/25 1PM
Texans
Titans
|
–
–
|
-370
+285
|
-7 (-110)
+7 (-110)
|
O 39.5 (-115)
U 39.5 (-105)
|
|
|
Nov 16, 2025 4:05PM EST
San Francisco 49ers
Arizona Cardinals
11/16/25 4:05PM
49ers
Cardinals
|
–
–
|
-140
+120
|
-2.5 (-110)
+2.5 (-110)
|
O 49 (-115)
U 49 (-105)
|
|
|
Nov 16, 2025 4:05PM EST
Seattle Seahawks
Los Angeles Rams
11/16/25 4:05PM
Seahawks
Rams
|
–
–
|
+135
-160
|
+3 (-115)
-3 (-105)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
|
Nov 16, 2025 4:25PM EST
Kansas City Chiefs
Denver Broncos
11/16/25 4:25PM
Chiefs
Broncos
|
–
–
|
-200
+170
|
-3.5 (-110)
+3.5 (-110)
|
O 44.5 (-105)
U 44.5 (-115)
|
|
|
Nov 16, 2025 4:25PM EST
Baltimore Ravens
Cleveland Browns
11/16/25 4:25PM
Ravens
Browns
|
–
–
|
-480
+350
|
-8 (-110)
+8 (-110)
|
O 41 (-115)
U 41 (-105)
|
|
|
Nov 16, 2025 8:20PM EST
Detroit Lions
Philadelphia Eagles
11/16/25 8:20PM
Lions
Eagles
|
–
–
|
+106
-124
|
+1.5 (-110)
-1.5 (-110)
|
O 48.5 (-105)
U 48.5 (-115)
|
|
|
Nov 17, 2025 8:15PM EST
Dallas Cowboys
Las Vegas Raiders
11/17/25 8:15PM
Cowboys
Raiders
|
–
–
|
-185
+160
|
-3.5 (+100)
+3.5 (-120)
|
O 50 (-110)
U 50 (-110)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Francisco 49ers vs. Los Angeles Rams Rams on September 22, 2024 at SoFi Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| LV@DEN | RILEY MOSS OVER 4.5 TACKLE + ASST | 54.8% | 4 | WIN |
| LV@DEN | UNDER 43 | 53.4% | 2 | WIN |
| ARI@DAL | BUDDA BAKER OVER 7.5 TACKLES + ASSTS | 54.4% | 4 | WIN |
| ARI@DAL | GEORGE PICKENS OVER 4.5 RECEPTIONS | 56.6% | 6 | WIN |
| DEN@HOU | WIL LUTZ OVER 1.5 MADE FIELD GOALS | 54.2% | 3 | LOSS |
| SEA@WAS | SEA -3 | 56.7% | 6 | WIN |
| IND@PIT | IND -3 | 56.8% | 6 | LOSS |
| LAC@TEN | LAC -9.5 | 56.2% | 6 | LOSS |
| CHI@CIN | CHI -2.5 | 52.6% | 2 | WIN |
| SEA@WAS | OVER 48 | 52.9% | 2 | WIN |
| SEA@WAS | JAYDEN DANIELS OVER 20.5 PASS COMP | 56.7% | 6 | LOSS |
| JAC@LV | JAC -140 | 64.2% | 7 | WIN |
| NO@LAR | LAR -14 | 55.0% | 4 | WIN |
| DEN@HOU | HOU -1.5 | 54.2% | 3 | LOSS |
| CAR@GB | GB -12.5 | 55.4% | 5 | LOSS |
| SF@NYG | NYG +2.5 | 56.1% | 5 | LOSS |
| BAL@MIA | TUA TAGOVAILOA UNDER 0.5 INT | 55.3% | 5 | LOSS |
| TB@NO | TB -3.5 | 52.3% | 1 | WIN |
| GB@PIT | GB -2.5 | 52.3% | 1 | WIN |
| SF@HOU | SF +2.5 | 56.0% | 6 | LOSS |
| NYG@PHI | NYG +7.5 | 53.9% | 3 | LOSS |
| BUF@CAR | CAR +7.5 | 54.2% | 3 | LOSS |
| DAL@DEN | DAL +3.5 | 55.0% | 4 | LOSS |
| MIA@ATL | MIA +7 | 54.3% | 4 | WIN |
| CLE@NE | CLE +7 | 56.8% | 6 | LOSS |
| TB@NO | BAKER MAYFIELD OVER 15.5 RUSH YDS | 56.6% | 6 | LOSS |
| MIN@LAC | JUSTIN HERBERT PASS ATT UNDER 35.5 | 55.5% | 5 | WIN |
| TB@DET | TB +6.5 | 54.4% | 4 | LOSS |
| TB@DET | RACHAAD WHITE UNDER 14.5 RUSH ATT | 54.4% | 4 | WIN |
| NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
| CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
| PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
| GB@ARI | ARI +7 | 54.8% | 5 | WIN |
| NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
| WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
| GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
| PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
| BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
| CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
| TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
| DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
| SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
| LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
| ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
| TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
| LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
| SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
| CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
| DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
| KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
| KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |