49ers vs Rams Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 22)

Updated: 2024-09-15T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The San Francisco 49ers face the Los Angeles Rams on September 22, 2024, at SoFi Stadium. The 49ers, coming off a 1-1 start, are the favorites in this NFC West clash, while the Rams seek their first win after a challenging 0-2 start.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 22, 2024

Start Time: 4:25 PM EST​

Venue: SoFi Stadium​

Rams Record: (0-2)

49ers Record: (1-1)

OPENING ODDS

SF Moneyline: -353

LAR Moneyline: +281

SF Spread: -7.5

LAR Spread: +7.5

Over/Under: 43

SF
Betting Trends

  • The 49ers are 1-1 ATS this season and have covered the spread in six of their last seven games as road favorites. Historically, they’ve performed well against NFC West opponents, having won 11 of the last 12 games against the Rams.

LAR
Betting Trends

  • The Rams are 0-2 ATS in 2024 and have struggled to cover in home games recently, especially as underdogs. They’ve failed to cover in five of their last six games as home underdogs against teams with a winning record.

MATCHUP TRENDS

  • The Rams have gone under the total points line in five of their last six games at home when facing NFC West opponents. Meanwhile, the 49ers have hit the over in five of their last seven road games, making the total points line of 43.5 something to monitor in this matchup.

SF vs. LAR
Best Prop Bet

  • Remi's searched hard and crunched the numbers and found the best prop bet play for this game: RB Jordan Mason to score a TOUCHDOWN

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San Francisco vs Los Angeles Rams Prediction & Odds:
Free NFL Betting Insights for 9/22/24

The San Francisco 49ers and Los Angeles Rams will meet in a highly anticipated NFC West battle in Week 3 of the 2024 NFL season at SoFi Stadium. The 49ers are entering the game as favorites with a 1-1 record. In their last outing, San Francisco fell 23-17 to the Minnesota Vikings, despite a strong showing from quarterback Brock Purdy, who threw for 319 yards. San Francisco’s ground game, led by Jordan Mason’s 100-yard performance, remains a focal point of their offense, helping them control the tempo of games. The Los Angeles Rams, on the other hand, are looking for their first win after starting 0-2. Their Week 2 loss was a 41-10 blowout to the Arizona Cardinals, exposing weaknesses in their defense.

Quarterback Matthew Stafford threw for 216 yards, but the team’s lack of a consistent ground attack, with Blake Corum leading the way with just 28 yards, has hampered their ability to keep up with opponents. Defensively, the Rams will need a major turnaround to contain San Francisco’s multifaceted offensive attack, especially as they struggle to generate pressure on opposing quarterbacks. This game will likely be decided by San Francisco’s ability to exploit the Rams’ defensive struggles. The 49ers will aim to maintain their balanced offensive attack while leaning on a strong run game to control possession. Meanwhile, the Rams will need Stafford to connect with key targets like Demarcus Robinson to have any hope of keeping pace with a 49ers team that has dominated this rivalry in recent seasons.

San Francisco 49ers NFL Preview

The San Francisco 49ers head into Week 3 looking to bounce back from a narrow 23-17 loss to the Minnesota Vikings. At 1-1, the 49ers remain one of the more balanced teams in the NFL. Quarterback Brock Purdy has shown composure, throwing for 519 yards and two touchdowns over two games. His ability to spread the ball to key playmakers like Deebo Samuel and Brandon Aiyuk has been critical to San Francisco’s offensive success. The 49ers’ rushing attack has been just as effective, averaging 141 yards per game, with Jordan Mason emerging as the lead back. The combination of a strong run game and efficient passing attack allows the 49ers to control the pace of the game, something they will look to do against a Rams defense that has struggled mightily. San Francisco’s defense, which ranks in the middle of the pack in terms of yards allowed, will also look to pressure Matthew Stafford and force him into mistakes. San Francisco’s game plan will revolve around their ability to exploit the Rams’ defensive weaknesses. If they can continue their balanced offensive approach and limit turnovers, the 49ers are in a strong position to earn their second win of the season.

The San Francisco 49ers face the Los Angeles Rams on September 22, 2024, at SoFi Stadium. The 49ers, coming off a 1-1 start, are the favorites in this NFC West clash, while the Rams seek their first win after a challenging 0-2 start. San Francisco vs Los Angeles Rams AI Prediction: Free NFL Betting Insights for Sep 22. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Los Angeles Rams Rams NFL Preview

The Los Angeles Rams are in a precarious position heading into their Week 3 matchup against the San Francisco 49ers. With an 0-2 start, the Rams’ season has been defined by struggles on both sides of the ball. In their latest outing, they were dismantled by the Arizona Cardinals 41-10. Quarterback Matthew Stafford has been effective at times, throwing for 432 yards across two games, but he has struggled to find consistency without a reliable running game. Blake Corum, their lead back, has been unable to gain much traction, putting added pressure on Stafford and the passing attack to carry the offense. Defensively, the Rams have been porous, allowing 30.5 points per game. The secondary has struggled to contain opposing wide receivers, and the lack of a consistent pass rush has left the defense vulnerable to big plays. For the Rams to compete with San Francisco, their defense will need to find ways to disrupt Brock Purdy’s rhythm and limit the effectiveness of the 49ers’ ground game. A key focus will be on limiting explosive plays from versatile threats like Deebo Samuel and George Kittle. The Rams have also been prone to turnovers, an area they must clean up to keep this game competitive. If they can limit mistakes and find a way to establish a balanced offensive attack, they might be able to hang with a formidable 49ers team. Otherwise, the Rams risk falling to 0-3 in what has been a difficult start to their season.

San Francisco vs. Los Angeles Rams Prop Picks (AI)

Remi is pouring through tons of stats on each line. In fact, anytime the 49ers and Rams play there’s always several intriguing angles to key in on. Not to mention games played at SoFi Stadium in Sep almost always follow normal, predictable patterns.
Remi's searched hard and crunched the numbers and found the best prop bet play for this game: RB Jordan Mason to score a TOUCHDOWN

San Francisco vs. Los Angeles Rams Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every facet between the 49ers and Rams and using recursive machine learning and impressive AI to examine the data to a single cover probability.

Remi has been most watching on the linear correlation of factor human bettors tend to put on player performance factors between a 49ers team going up against a possibly rested Rams team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI San Francisco vs Los Angeles Rams picks, computer picks 49ers vs Rams, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NFL 10/20 HOU@SEA UNLOCK THIS PICK 5 INTEL Locked INTEL
NFL 10/20 TB@DET UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/20 TB@DET UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 10/20 TB@DET UNLOCK THIS PICK 1 INTEL Locked INTEL
NFL 10/20 HOU@SEA UNLOCK THIS PICK 0 INTEL Locked INTEL
NFL 10/20 TB@DET UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

49ers Betting Trends

The 49ers are 1-1 ATS this season and have covered the spread in six of their last seven games as road favorites. Historically, they’ve performed well against NFC West opponents, having won 11 of the last 12 games against the Rams.

Rams Betting Trends

The Rams are 0-2 ATS in 2024 and have struggled to cover in home games recently, especially as underdogs. They’ve failed to cover in five of their last six games as home underdogs against teams with a winning record.

49ers vs. Rams Matchup Trends

The Rams have gone under the total points line in five of their last six games at home when facing NFC West opponents. Meanwhile, the 49ers have hit the over in five of their last seven road games, making the total points line of 43.5 something to monitor in this matchup.

San Francisco vs. Los Angeles Rams Game Info

San Francisco vs Los Angeles Rams starts on September 22, 2024 at 4:25 PM EST.

Spread: Los Angeles Rams +7.5
Moneyline: San Francisco -353, Los Angeles Rams +281
Over/Under: 43

San Francisco: (1-1)  |  Los Angeles Rams: (0-2)

Remi's searched hard and crunched the numbers and found the best prop bet play for this game: RB Jordan Mason to score a TOUCHDOWN. Prices move—always shop for the best number.

The Rams have gone under the total points line in five of their last six games at home when facing NFC West opponents. Meanwhile, the 49ers have hit the over in five of their last seven road games, making the total points line of 43.5 something to monitor in this matchup.

SF trend: The 49ers are 1-1 ATS this season and have covered the spread in six of their last seven games as road favorites. Historically, they’ve performed well against NFC West opponents, having won 11 of the last 12 games against the Rams.

LAR trend: The Rams are 0-2 ATS in 2024 and have struggled to cover in home games recently, especially as underdogs. They’ve failed to cover in five of their last six games as home underdogs against teams with a winning record.

See our latest NFL picks and odds pages for 2024 to compare prices before you bet.

San Francisco vs. Los Angeles Rams Odds

AI algorithm Remi is pouring through loads of data points on each team. In fact, anytime the San Francisco vs Los Angeles Rams trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps almost always follow normal, predictable patterns.

San Francisco vs Los Angeles Rams Opening Odds

SF Moneyline: -353
LAR Moneyline: +281
SF Spread: -7.5
LAR Spread: +7.5
Over/Under: 43

San Francisco vs Los Angeles Rams Live Odds

Games PTS ML SPR O/U
Oct 23, 2025 8:15PM EDT
Minnesota Vikings
Los Angeles Chargers
10/23/25 8:15PM
Vikings
Chargers
+148
-185
+3 (+100)
-3 (-120)
O 44.5 (-110)
U 44.5 (-110)
Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
+270
-374
+7 (-110)
-7 (-110)
O 40.5 (-110)
U 40.5 (-110)
Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
-463
+321
-7.5 (-110)
+7.5 (-110)
O 46 (-110)
U 46 (-110)
Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
+242
-330
+7 (-110)
-7 (-110)
O 44.5 (-110)
U 44.5 (-110)
Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
+229
-315
+6.5 (+100)
-6.5 (-120)
O 50.5 (-110)
U 50.5 (-110)
Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
+287
-407
+7 (-110)
-7 (-110)
O 43.5 (-110)
U 43.5 (-110)
Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
-110
-116
+1 (-110)
-1 (-110)
O 41.5 (-110)
U 41.5 (-110)
Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
+257
-355
+7 (-110)
-7 (-110)
O 44.5 (-110)
U 44.5 (-110)
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
-220
+169
-4.5 (-110)
+4.5 (-110)
O 47 (-110)
U 47 (-110)
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
+141
-181
+3.5 (-120)
-3.5 (+100)
O 50 (-110)
U 50 (-110)
Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
+682
-1442
+14 (-110)
-14 (-110)
O 47 (-110)
U 47 (-110)
Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
-192
+148
-3.5 (+100)
+3.5 (-120)
O 44.5 (-110)
U 44.5 (-110)
Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
+390
-599
+10.5 (-110)
-10.5 (-110)
O 47.5 (-110)
U 47.5 (-110)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Francisco 49ers vs. Los Angeles Rams Rams on September 22, 2024 at SoFi Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS
HOU@BAL HOU -125 58.5% 7 WIN
DET@CIN DET -10 55.6% 5 WIN
DAL@NYJ NYJ +1.5 53.7% 3 LOSS
TB@SEA TB +3.5 54.9% 4 WIN
TEN@ARI ARI -7 (BUY 0.5) 54.9% 4 LOSS
DEN@PHI DEN +4.5 57.5% 7 WIN
MIA@CAR TETAIROA MCMILLAN OVER 58.5 RECV YDS 54.5% 4 WIN
LV@IND ASHTON JEANTY UNDER 67.5 RUSH YDS 54.4% 4 WIN
SF@LAR DEMARCUS ROBINSON OVER 29.5 RECV YDS 55.7% 5 WIN
NYJ@MIA NYJ +3 53.8 3 LOSS
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS
TEN@HOU TEN +7.5 57.9% 7 LOSS
LAC@NYG LAC -6 57.3% 7 LOSS
NO@BUF UNDER 48.5 55.1% 3 LOSS
GB@DAL JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS 55.5% 5 LOSS
CAR@NE DRAKE MAYE TO THROW AN INT 56.6% 6 LOSS
SEA@ARI SEA -125 57.7% 6 WIN
SEA@ARI KYLER MURRAY TO THROW AN INT 56.6% 6 WIN
DET@BAL JAHMYR GIBBS OVER 0.5 RUSH TDS 55.8% 5 WIN
DAL@CHI DAL -120 58.7% 6 LOSS
PIT@NE PIT -116 60.1% 6 WIN
ATL@CAR ATL -4.5 55.4% 5 LOSS
LV@WAS LV +3 54.3% 4 LOSS