Giants vs Browns Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 22)
Updated: 2024-09-15T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The New York Giants will face the Cleveland Browns on September 22, 2024, at Huntington Bank Field. The Browns come in as 6-point favorites after a mixed start to the season, while the Giants are seeking their first win of the year.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 22, 2024
Start Time: 1:00 PM EST
Venue: Huntington Bank Field
Browns Record: (1-1)
Giants Record: (0-2)
OPENING ODDS
NYG Moneyline: +231
CLE Moneyline: -282
NYG Spread: +6.5
CLE Spread: -6.5
Over/Under: 38.5
NYG
Betting Trends
- The Giants have performed well as road underdogs, covering the spread in each of their last five games in such situations following a division game. However, they are 0-2 against the spread (ATS) this season and have struggled offensively.
CLE
Betting Trends
- The Browns have struggled ATS at home, failing to cover in three of their last four games. They also have a poor record against NFC East opponents, losing six of their last seven September games against this division.
MATCHUP TRENDS
- The total points line for each of the Giants’ last six September games as underdogs has gone under. Conversely, five of the Browns’ last six games have gone over the total points line, making the over/under a key factor to consider for this matchup.
NYG vs. CLE
Best Prop Bet
- Remi's searched hard and crunched the numbers and found the best prop bet play for this game: WR Amari Cooper Over 55.5 Receiving Yards
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New York Giants vs Cleveland Prediction & Odds:
Free NFL Betting Insights for 9/22/24
Cleveland’s ground game, led by Jerome Ford and Nick Chubb, has been more reliable, which could be crucial against a Giants defense that has allowed 326 rushing yards in two games. The Browns’ defense, featuring stalwarts like Myles Garrett and Jeremiah Owusu-Koramoah, needs to replicate their Week 2 performance to suppress the Giants’ offense. While the Browns have shown a better form in their last outing, their offensive inconsistencies, particularly on third down (only 13.8% conversion), could keep the game closer than expected.
On this day: In 2006, Plaxico Burress caught a game-winning TD for a 30-24 comeback OT win pic.twitter.com/zbemXik7tD
— New York Giants (@Giants) September 17, 2024
New York Giants Giants NFL Preview
The New York Giants head into Cleveland looking for their first win of the 2024 season. After starting 0-2, the Giants face an uphill battle, but their recent record as road underdogs gives them some hope. Quarterback Daniel Jones has shown flashes of potential but has also struggled with turnovers and inconsistency, particularly in the first game against the Vikings. Jones will need to be more accurate and avoid costly mistakes to keep the Giants competitive. The running game, led by Devin Singletary, has been a relative strength, with Singletary recording 95 rushing yards and a touchdown in the loss to the Commanders. Defensively, the Giants have not fared much better. They are giving up an average of 24.5 points per game and have been porous against the run, allowing 163 rushing yards per game. This is an area that needs immediate improvement, especially facing a Browns team that relies heavily on the ground attack. For the Giants to pull off an upset, their defense must contain Cleveland’s rushing duo of Chubb and Ford and force Watson into errors. The return to form of key defenders and more disciplined play overall will be crucial.
Credit: USA TODAY/IMAGN
Cleveland Browns NFL Preview
The Cleveland Browns aim to build on their recent victory as they host the New York Giants. After a shaky start to the season with a lopsided loss to the Dallas Cowboys, the Browns bounced back with a hard-fought win over the Jacksonville Jaguars. Quarterback Deshaun Watson, who has 355 passing yards with one touchdown and two interceptions so far, will need to be more efficient. The Browns’ offense has leaned heavily on the ground game, with Jerome Ford and Nick Chubb combining for significant yardage. Ford, in particular, has shown promise, and his ability to break through the Giants’ struggling run defense could be the key to the Browns controlling the game. Defensively, Cleveland’s unit has improved, allowing just 17.5 points per game. Myles Garrett, leading the pass rush, and Jeremiah Owusu-Koramoah, anchoring the linebacking corps, are critical in maintaining this defensive pressure. However, their vulnerability in the secondary and on third downs needs addressing. Against the Giants, the Browns’ defense will look to exploit the Giants’ offensive line woes and force turnovers, a category in which the Browns have excelled with a positive turnover margin in simulations.
We've placed WR David Bell on injured reserve
— Cleveland Browns (@Browns) September 17, 2024
📰 » https://t.co/SAdhkjb2Rv pic.twitter.com/lFpNx8ZKHf
New York Giants vs. Cleveland Prop Picks (AI)
New York Giants vs. Cleveland Prediction (AI)
Remi, our AI sports wizard, has been pouring over tons of data from every simulation between the Giants and Browns and using recursive machine learning and kick-ass AI to crunch the data to a single cover probability.
Remi has been most focused on the linear correlation of factor knucklehead sportsbettors often put on coaching factors between a Giants team going up against a possibly deflated Browns team. Trends look to say the true game analytics appear to reflect a strong lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI New York Giants vs Cleveland picks, computer picks Giants vs Browns, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 5 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 1 |
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| NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 0 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Giants Betting Trends
The Giants have performed well as road underdogs, covering the spread in each of their last five games in such situations following a division game. However, they are 0-2 against the spread (ATS) this season and have struggled offensively.
Browns Betting Trends
The Browns have struggled ATS at home, failing to cover in three of their last four games. They also have a poor record against NFC East opponents, losing six of their last seven September games against this division.
Giants vs. Browns Matchup Trends
The total points line for each of the Giants’ last six September games as underdogs has gone under. Conversely, five of the Browns’ last six games have gone over the total points line, making the over/under a key factor to consider for this matchup.
New York Giants vs. Cleveland Game Info
What time does New York Giants vs Cleveland start on September 22, 2024?
New York Giants vs Cleveland starts on September 22, 2024 at 1:00 PM EST.
Where is New York Giants vs Cleveland being played?
Venue: Huntington Bank Field.
What are the opening odds for New York Giants vs Cleveland?
Spread: Cleveland -6.5
Moneyline: New York Giants +231, Cleveland -282
Over/Under: 38.5
What are the records for New York Giants vs Cleveland?
New York Giants: (0-2) | Cleveland: (1-1)
What is the AI best bet for New York Giants vs Cleveland?
Remi's searched hard and crunched the numbers and found the best prop bet play for this game: WR Amari Cooper Over 55.5 Receiving Yards. Prices move—always shop for the best number.
What are New York Giants vs Cleveland trending bets?
The total points line for each of the Giants’ last six September games as underdogs has gone under. Conversely, five of the Browns’ last six games have gone over the total points line, making the over/under a key factor to consider for this matchup.
What are New York Giants trending bets?
NYG trend: The Giants have performed well as road underdogs, covering the spread in each of their last five games in such situations following a division game. However, they are 0-2 against the spread (ATS) this season and have struggled offensively.
What are Cleveland trending bets?
CLE trend: The Browns have struggled ATS at home, failing to cover in three of their last four games. They also have a poor record against NFC East opponents, losing six of their last seven September games against this division.
Where can I find AI Picks for New York Giants vs Cleveland?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
New York Giants vs. Cleveland Odds
AI algorithm Remi is pouring through loads of stats on each player. In fact, anytime the New York Giants vs Cleveland trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance rarely follow normal, predictable betting trends.
New York Giants vs Cleveland Opening Odds
NYG Moneyline:
+231 CLE Moneyline: -282
NYG Spread: +6.5
CLE Spread: -6.5
Over/Under: 38.5
New York Giants vs Cleveland Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Oct 23, 2025 8:15PM EDT
Minnesota Vikings
Los Angeles Chargers
10/23/25 8:15PM
Vikings
Chargers
|
–
–
|
+148
-185
|
+3 (+100)
-3 (-120)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
|
–
–
|
+270
-374
|
+7 (-110)
-7 (-110)
|
O 40.5 (-110)
U 40.5 (-110)
|
|
|
Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
|
–
–
|
-463
+321
|
-7.5 (-110)
+7.5 (-110)
|
O 46 (-110)
U 46 (-110)
|
|
|
Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
|
–
–
|
+242
-330
|
+7 (-110)
-7 (-110)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
|
–
–
|
+229
-315
|
+6.5 (+100)
-6.5 (-120)
|
O 50.5 (-110)
U 50.5 (-110)
|
|
|
Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
|
–
–
|
+287
-407
|
+7 (-110)
-7 (-110)
|
O 43.5 (-110)
U 43.5 (-110)
|
|
|
Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
|
–
–
|
-110
-116
|
+1 (-110)
-1 (-110)
|
O 41.5 (-110)
U 41.5 (-110)
|
|
|
Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
|
–
–
|
+257
-355
|
+7 (-110)
-7 (-110)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
|
–
–
|
-220
+169
|
-4.5 (-110)
+4.5 (-110)
|
O 47 (-110)
U 47 (-110)
|
|
|
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
|
–
–
|
+141
-181
|
+3.5 (-120)
-3.5 (+100)
|
O 50 (-110)
U 50 (-110)
|
|
|
Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
|
–
–
|
+682
-1442
|
+14 (-110)
-14 (-110)
|
O 47 (-110)
U 47 (-110)
|
|
|
Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
|
–
–
|
-192
+148
|
-3.5 (+100)
+3.5 (-120)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
|
–
–
|
+390
-599
|
+10.5 (-110)
-10.5 (-110)
|
O 47.5 (-110)
U 47.5 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers New York Giants Giants vs. Cleveland Browns on September 22, 2024 at Huntington Bank Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
| CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
| PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
| GB@ARI | ARI +7 | 54.8% | 5 | WIN |
| NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
| WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
| GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
| PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
| BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
| CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
| TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
| DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
| SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
| LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
| ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
| TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
| LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
| SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
| CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
| DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
| KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
| KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
| HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
| DET@CIN | DET -10 | 55.6% | 5 | WIN |
| DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
| TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
| TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
| DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
| MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
| LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
| SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
| NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
| CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
| NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
| CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
| NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
| CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
| WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
| BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
| TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
| LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
| NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
| GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
| CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |