Lions vs Cardinals Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 22)
Updated: 2024-09-15T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Detroit Lions will face the Arizona Cardinals on September 22, 2024, at State Farm Stadium in Week 3 of the NFL season. Both teams have a 1-1 record and are looking to gain momentum early in the season. The Lions enter as slight favorites, but the Cardinals have shown resilience at home.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 22, 2024
Start Time: 4:25 PM EST
Venue: State Farm Stadium
Cardinals Record: (1-1)
Lions Record: (1-1)
OPENING ODDS
DET Moneyline: -149
ARI Moneyline: +125
DET Spread: -3
ARI Spread: +3.0
Over/Under: 52.5
DET
Betting Trends
- The Lions are 1-1 against the spread (ATS) this season and have won six of their last nine road games. However, they have struggled as favorites against NFC West teams, failing to cover the spread in four of their last five games in this scenario.
ARI
Betting Trends
- The Cardinals are 1-1 ATS this season and have performed well at home in September, covering the spread in each of their last five home games in the month. They’ve also won the first half in five consecutive September games.
MATCHUP TRENDS
- The Cardinals have scored the first touchdown in six of their last seven Week 3 games, while the Lions have failed to cover the spread in four of their last five games as favorites against NFC West opponents.
DET vs. ARI
Best Prop Bet
- Remi's searched hard and crunched the numbers and found the best prop bet play for this game: TE Trey McBride Over 52.5 Receiving Yards
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Detroit vs Arizona Prediction & Odds:
Free NFL Betting Insights for 9/22/24
The Cardinals’ ground game, spearheaded by James Conner, has been particularly strong, averaging 177.5 rushing yards per game. Conner has been a consistent force, and his ability to wear down defenses could be a critical factor in this matchup. Defensively, Arizona limited the Rams to just 245 total yards, showcasing an ability to control the pace of the game. The Lions will need to rely on their own run game, led by David Montgomery, who has rushed for 126 yards and two touchdowns so far this season. Detroit’s defense, which is allowing 20 points per game, will face a tough test in containing Murray and Conner. This game is likely to come down to which team can execute better in the red zone and avoid turnovers. If Goff can minimize mistakes and the Lions’ defense can limit Arizona’s explosive plays, Detroit could escape with a close win. However, the Cardinals’ home-field advantage and strong recent performances in September could give them the edge.
Aidan did his thing@aidanhutch97 pic.twitter.com/AKkFbskZDN
— Detroit Lions (@Lions) September 17, 2024
Detroit Lions NFL Preview
The Detroit Lions head into this Week 3 matchup following a frustrating loss to the Tampa Bay Buccaneers, where they struggled to capitalize on offensive opportunities despite outgaining their opponent in total yards. Jared Goff has been efficient overall, completing 62.7% of his passes for 524 yards, but his three interceptions through two games have been costly. Detroit’s rushing attack, led by David Montgomery, has been a bright spot, averaging 151 rushing yards per game. Montgomery’s power running will be key to balancing the Lions’ offensive attack and keeping Arizona’s defense on its heels. Defensively, Detroit has been solid, allowing just 301.5 yards per game. Aidan Hutchinson has been a standout with 5.5 sacks, and the Lions will look to put pressure on Kyler Murray to disrupt Arizona’s passing game. However, the Lions’ secondary will need to step up to limit big plays from Murray and Marvin Harrison Jr., who has been a deep threat for the Cardinals. Detroit will also need to improve their red zone efficiency if they hope to win on the road. With Goff leading a capable offense, the Lions have the firepower to compete, but they will need a more disciplined performance to secure a victory.
Credit: USA TODAY/IMAGN
Arizona Cardinals NFL Preview
The Arizona Cardinals are coming off a dominant Week 2 win against the Los Angeles Rams, where they showcased both offensive firepower and defensive resilience. Kyler Murray was instrumental, throwing for 266 yards and three touchdowns, while also contributing on the ground with 57 rushing yards. Arizona’s ground game, led by James Conner, has been one of the strongest in the league so far, averaging 177.5 rushing yards per game. Conner has been a key figure in the Cardinals’ offense, with 172 rushing yards and two touchdowns through two games. Defensively, the Cardinals have been solid, allowing just 298.5 yards per game. Budda Baker leads the defense with 18 tackles, and Dennis Gardeck has contributed three sacks. Arizona’s defense will aim to contain a Lions offense that has been productive but prone to mistakes. Key to Arizona’s success will be forcing Goff into turnovers and controlling the game through their strong running attack. Given their track record in September and success in recent home games, the Cardinals are well-positioned to pull off an upset against the favored Lions.
All the trust in QB1. pic.twitter.com/UX8B4jED15
— Arizona Cardinals (@AZCardinals) September 18, 2024
Detroit vs. Arizona Prop Picks (AI)
Detroit vs. Arizona Prediction (AI)
Remi, our AI sports wizard, has been pouring over millions of data from every facet between the Lions and Cardinals and using recursive machine learning and impressive AI to analyze the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most keyed in on the growing factor emotional bettors often put on Detroit’s strength factors between a Lions team going up against a possibly deflated Cardinals team. It appears the true game analytics might reflect a moderate lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Detroit vs Arizona picks, computer picks Lions vs Cardinals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 5 |
INTEL
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
EXECUTIVE
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 1 |
INTEL
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| NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 0 |
INTEL
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 0 |
INTEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Lions Betting Trends
The Lions are 1-1 against the spread (ATS) this season and have won six of their last nine road games. However, they have struggled as favorites against NFC West teams, failing to cover the spread in four of their last five games in this scenario.
Cardinals Betting Trends
The Cardinals are 1-1 ATS this season and have performed well at home in September, covering the spread in each of their last five home games in the month. They’ve also won the first half in five consecutive September games.
Lions vs. Cardinals Matchup Trends
The Cardinals have scored the first touchdown in six of their last seven Week 3 games, while the Lions have failed to cover the spread in four of their last five games as favorites against NFC West opponents.
Detroit vs. Arizona Game Info
What time does Detroit vs Arizona start on September 22, 2024?
Detroit vs Arizona starts on September 22, 2024 at 4:25 PM EST.
Where is Detroit vs Arizona being played?
Venue: State Farm Stadium.
What are the opening odds for Detroit vs Arizona?
Spread: Arizona +3.0
Moneyline: Detroit -149, Arizona +125
Over/Under: 52.5
What are the records for Detroit vs Arizona?
Detroit: (1-1) | Arizona: (1-1)
What is the AI best bet for Detroit vs Arizona?
Remi's searched hard and crunched the numbers and found the best prop bet play for this game: TE Trey McBride Over 52.5 Receiving Yards. Prices move—always shop for the best number.
What are Detroit vs Arizona trending bets?
The Cardinals have scored the first touchdown in six of their last seven Week 3 games, while the Lions have failed to cover the spread in four of their last five games as favorites against NFC West opponents.
What are Detroit trending bets?
DET trend: The Lions are 1-1 against the spread (ATS) this season and have won six of their last nine road games. However, they have struggled as favorites against NFC West teams, failing to cover the spread in four of their last five games in this scenario.
What are Arizona trending bets?
ARI trend: The Cardinals are 1-1 ATS this season and have performed well at home in September, covering the spread in each of their last five home games in the month. They’ve also won the first half in five consecutive September games.
Where can I find AI Picks for Detroit vs Arizona?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
Detroit vs. Arizona Odds
AI algorithm Remi is pouring through tons of data points on each team. In fact, anytime the Detroit vs Arizona trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable patterns.
Detroit vs Arizona Opening Odds
DET Moneyline:
-149 ARI Moneyline: +125
DET Spread: -3
ARI Spread: +3.0
Over/Under: 52.5
Detroit vs Arizona Live Odds
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|---|---|---|---|---|---|
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–
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O 45 (-110)
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O 40.5 (-110)
U 40.5 (-110)
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-400
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O 45.5 (-110)
U 45.5 (-110)
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–
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+250
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+6.5 (-105)
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O 44.5 (-105)
U 44.5 (-115)
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Ravens
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–
–
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+265
-325
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+7 (-120)
-7 (+100)
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O 50 (-110)
U 50 (-110)
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Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
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Giants
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–
–
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+290
-360
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+7 (-105)
-7 (-115)
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O 43.5 (-115)
U 43.5 (-105)
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Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
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–
–
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-110
-106
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-1.5 (-104)
+1.5 (-118)
|
O 41.5 (-115)
U 41.5 (-105)
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Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
|
–
–
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+280
-350
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+7 (-110)
-7 (-110)
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O 44.5 (-110)
U 44.5 (-110)
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Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
|
–
–
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-220
+184
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-4.5 (-112)
+4.5 (-108)
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O 47.5 (-105)
U 47.5 (-115)
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Oct 26, 2025 4:25PM EDT
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Denver Broncos
10/26/25 4:25PM
Cowboys
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|
–
–
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+146
-170
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+3 (+100)
-3 (-120)
|
O 49.5 (-110)
U 49.5 (-110)
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Oct 26, 2025 4:25PM EDT
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Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
|
–
–
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+750
-1200
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+14 (-110)
-14 (-110)
|
O 47 (-110)
U 47 (-110)
|
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Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
|
–
–
|
-185
+159
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-3.5 (-105)
+3.5 (-115)
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O 45 (-113)
U 45 (-107)
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Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
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–
–
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+465
-630
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+10.5 (-115)
-10.5 (-105)
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O 48.5 (-110)
U 48.5 (-110)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Detroit Lions vs. Arizona Cardinals on September 22, 2024 at State Farm Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
| CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
| PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
| GB@ARI | ARI +7 | 54.8% | 5 | WIN |
| NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
| WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
| GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
| PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
| BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
| CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
| TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
| DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
| SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
| LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
| ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
| TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
| LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
| SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
| CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
| DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
| KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
| KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
| HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
| DET@CIN | DET -10 | 55.6% | 5 | WIN |
| DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
| TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
| TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
| DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
| MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
| LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
| SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
| NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
| CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
| NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
| CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
| NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
| CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
| WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
| BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
| TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
| LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
| NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
| GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
| CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |