Bears vs Colts Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 22)
Updated: 2024-09-15T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Chicago Bears will face the Indianapolis Colts on September 22, 2024, at Lucas Oil Stadium. The Colts, still searching for their first win, are slightly favored against the Bears, who are looking to rebound from a loss in their previous game.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 22, 2024
Start Time: 1:00 PM EST
Venue: Lucas Oil Stadium
Colts Record: (0-2)
Bears Record: (1-1)
OPENING ODDS
CHI Moneyline: -100
IND Moneyline: -120
CHI Spread: +1
IND Spread: -1.0
Over/Under: 43.5
CHI
Betting Trends
- The Bears have struggled as underdogs, failing to cover the spread in 12 of their last 14 games against teams with a losing record. Additionally, they have lost 18 of their last 19 Sunday road games.
IND
Betting Trends
- The Colts have been more reliable in Week 3 matchups, covering the spread in seven of their last eight games in this scenario. They have also seen the favorites win the first half in five of their last six games.
MATCHUP TRENDS
- Eight of the Colts’ last nine Sunday home games have gone over the total points line, while each of the Bears’ last five games as underdogs has gone under the total points line. This contrast makes the over/under an intriguing aspect for bettors to consider.
CHI vs. IND
Best Prop Bet
- Remi's searched hard and crunched the numbers and found the best prop bet play for this game: Punter Rigoberto Sanchez Over 1.5 Punts inside the 20 yard line
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Chicago vs Indianapolis Prediction & Odds:
Free NFL Betting Insights for 9/22/24
The Colts’ defense, however, has been inconsistent, particularly against the run. They allowed 261 rushing yards in their last game against the Packers, which is a vulnerability the Bears could exploit if they can get their ground game going. Both teams have shown they can play well in stretches but lack consistency. The Colts have been more reliable in Week 3 scenarios and tend to perform better at home, while the Bears have struggled significantly on the road. The key for the Colts will be limiting turnovers and maintaining control of the game with their running attack. The Bears will need a more balanced offensive approach and a stronger defensive showing to limit the Colts’ scoring opportunities. This game could come down to which team makes fewer mistakes and is more efficient on third downs.
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— Chicago Bears (@ChicagoBears) September 17, 2024
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Chicago Bears NFL Preview
The Chicago Bears are looking to bounce back after a disappointing 19-13 loss to the Houston Texans in Week 2. The Bears have struggled on offense, with quarterback Caleb Williams still finding his footing in the league. He managed only 174 yards with two interceptions against the Texans and was sacked seven times, highlighting significant issues along the offensive line. The Bears need to improve pass protection to give Williams the time necessary to make plays. On the ground, D’Andre Swift has shown some promise, but the running game has yet to become a consistent threat. Defensively, the Bears have had mixed results. They’ve been relatively strong against the pass, allowing just over 235 yards per game, but they have not been able to generate enough pressure on opposing quarterbacks consistently. Chicago’s defense allowed 300 yards of total offense in their loss to the Texans and will need to tighten up against the Colts’ balanced attack. The Bears’ success on Sunday will depend heavily on their ability to protect the quarterback and generate takeaways on defense. Improving their third-down efficiency and maintaining better discipline to avoid penalties will be key factors as they seek their second win of the season.
Credit: USA TODAY/IMAGN
Indianapolis Colts NFL Preview
The Indianapolis Colts are entering Week 3 of the NFL season desperate for a win after starting 0-2. Their season opener against the Houston Texans resulted in a narrow 29-27 loss, and they followed that with a 16-10 defeat at the hands of the Green Bay Packers. In both games, the Colts showed potential but were hampered by costly mistakes, particularly from quarterback Anthony Richardson, who has thrown three touchdowns against four interceptions in his first two games. His performance needs to stabilize if the Colts hope to turn their season around. Jonathan Taylor remains the focal point of the Colts’ offense. In their last game, Taylor rushed for 103 yards on 12 carries, showcasing his ability to break long runs and create scoring opportunities. The Colts’ defense, however, has been porous, particularly against the run, as they allowed over 260 rushing yards to the Packers. Improving defensive efficiency, especially on third down and in the red zone, will be crucial for Indianapolis. Their secondary has been more effective, limiting opposing quarterbacks, but they must tighten up their run defense to prevent the Bears from controlling the game tempo. If the Colts can establish their ground game and limit turnovers, they should be in a good position to secure their first victory.
We have signed DE Genard Avery to the 53-man roster from the practice squad and placed DT DeForest Buckner on IR.
— Indianapolis Colts (@Colts) September 17, 2024
We have signed DT Adam Gotsis, CB Gregory Junior and DE Titus Leo to the practice squad and released DT McTelvin Agim and CB Ameer Speed from the practice squad.
Chicago vs. Indianapolis Prop Picks (AI)
Chicago vs. Indianapolis Prediction (AI)
Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every simulation between the Bears and Colts and using recursive machine learning and impressive AI to analyze the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most watching on the linear correlation of emphasis knucklehead sportsbettors often put on Indianapolis’s strength factors between a Bears team going up against a possibly strong Colts team. It appears the true game analytics might reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Chicago vs Indianapolis picks, computer picks Bears vs Colts, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 5 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 1 |
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| NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 0 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Bears Betting Trends
The Bears have struggled as underdogs, failing to cover the spread in 12 of their last 14 games against teams with a losing record. Additionally, they have lost 18 of their last 19 Sunday road games.
Colts Betting Trends
The Colts have been more reliable in Week 3 matchups, covering the spread in seven of their last eight games in this scenario. They have also seen the favorites win the first half in five of their last six games.
Bears vs. Colts Matchup Trends
Eight of the Colts’ last nine Sunday home games have gone over the total points line, while each of the Bears’ last five games as underdogs has gone under the total points line. This contrast makes the over/under an intriguing aspect for bettors to consider.
Chicago vs. Indianapolis Game Info
What time does Chicago vs Indianapolis start on September 22, 2024?
Chicago vs Indianapolis starts on September 22, 2024 at 1:00 PM EST.
Where is Chicago vs Indianapolis being played?
Venue: Lucas Oil Stadium.
What are the opening odds for Chicago vs Indianapolis?
Spread: Indianapolis -1.0
Moneyline: Chicago -100, Indianapolis -120
Over/Under: 43.5
What are the records for Chicago vs Indianapolis?
Chicago: (1-1) | Indianapolis: (0-2)
What is the AI best bet for Chicago vs Indianapolis?
Remi's searched hard and crunched the numbers and found the best prop bet play for this game: Punter Rigoberto Sanchez Over 1.5 Punts inside the 20 yard line. Prices move—always shop for the best number.
What are Chicago vs Indianapolis trending bets?
Eight of the Colts’ last nine Sunday home games have gone over the total points line, while each of the Bears’ last five games as underdogs has gone under the total points line. This contrast makes the over/under an intriguing aspect for bettors to consider.
What are Chicago trending bets?
CHI trend: The Bears have struggled as underdogs, failing to cover the spread in 12 of their last 14 games against teams with a losing record. Additionally, they have lost 18 of their last 19 Sunday road games.
What are Indianapolis trending bets?
IND trend: The Colts have been more reliable in Week 3 matchups, covering the spread in seven of their last eight games in this scenario. They have also seen the favorites win the first half in five of their last six games.
Where can I find AI Picks for Chicago vs Indianapolis?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
Chicago vs. Indianapolis Odds
AI algorithm Remi is pouring through loads of data on each line. In fact, anytime the Chicago vs Indianapolis trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps can often follow normal, predictable patterns.
Chicago vs Indianapolis Opening Odds
CHI Moneyline:
-100 IND Moneyline: -120
CHI Spread: +1
IND Spread: -1.0
Over/Under: 43.5
Chicago vs Indianapolis Live Odds
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|---|---|---|---|---|---|
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–
–
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+229
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+6.5 (+100)
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O 50.5 (-110)
U 50.5 (-110)
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Giants
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–
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+287
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+7 (-110)
-7 (-110)
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O 43.5 (-110)
U 43.5 (-110)
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Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
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49ers
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–
–
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-110
-116
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+1 (-110)
-1 (-110)
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O 41.5 (-110)
U 41.5 (-110)
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Oct 26, 2025 1:00PM EDT
Miami Dolphins
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10/26/25 1PM
Dolphins
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–
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+257
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+7 (-110)
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O 44.5 (-110)
U 44.5 (-110)
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Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
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Buccaneers
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–
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-220
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-4.5 (-110)
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O 47 (-110)
U 47 (-110)
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Cowboys
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–
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+141
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+3.5 (-120)
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O 50 (-110)
U 50 (-110)
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–
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+682
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+14 (-110)
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O 47 (-110)
U 47 (-110)
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Packers
Steelers
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–
–
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-192
+148
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-3.5 (+100)
+3.5 (-120)
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O 44.5 (-110)
U 44.5 (-110)
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Oct 27, 2025 8:15PM EDT
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Commanders
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–
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+390
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+10.5 (-110)
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O 47.5 (-110)
U 47.5 (-110)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Chicago Bears vs. Indianapolis Colts on September 22, 2024 at Lucas Oil Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
| CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
| PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
| GB@ARI | ARI +7 | 54.8% | 5 | WIN |
| NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
| WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
| GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
| PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
| BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
| CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
| TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
| DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
| SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
| LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
| ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
| TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
| LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
| SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
| CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
| DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
| KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
| KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
| HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
| DET@CIN | DET -10 | 55.6% | 5 | WIN |
| DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
| TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
| TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
| DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
| MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
| LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
| SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
| NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
| CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
| NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
| CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
| NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
| CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
| WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
| BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
| TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
| LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
| NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
| GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
| CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |