49ers vs Vikings Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 15)

Updated: 2024-09-08T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The San Francisco 49ers will face the Minnesota Vikings at U.S. Bank Stadium on September 15, 2024. The 49ers are coming off a dominant Week 1 performance, while the Vikings are also 1-0, aiming to continue their strong start to the season. The 49ers are favored to win, but the Vikings’ strong home performance could make this a competitive matchup.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 15, 2024

Start Time: 1:00 PM EST​

Venue: U.S. Bank Stadium​

Vikings Record: (1-0)

49ers Record: (1-0)

OPENING ODDS

SF Moneyline: -265

MIN Moneyline: +216

SF Spread: -6

MIN Spread: +6.0

Over/Under: 45.5

SF
Betting Trends

  • The San Francisco 49ers have a strong record against the spread (ATS) as favorites, covering in eight of their last nine games against NFC opponents. They have also won each of their last 10 games as favorites before a division game, highlighting their ability to perform well when expected to win.

MIN
Betting Trends

  • The Minnesota Vikings have struggled ATS, failing to cover the spread in six of their last seven games. However, they have a strong 4th down conversion rate and red zone efficiency, ranking first in the NFL in both categories this season, which could play a crucial role in keeping the game close.

MATCHUP TRENDS

  • Seven of the 49ers’ last eight games as favorites following a win have gone over the total points line. Similarly, six of the Vikings’ last seven games as underdogs have also gone over the total points line. This trend suggests a higher-scoring game may be likely.

SF vs. MIN
Best Prop Bet

  • Remi searched hard and crunched the numbers and found a prop bet for the San Francisco 49ers vs Minnesota Vikings matchup. Prop Bet: Brandon Aiyuk Over 4.5 Receptions

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San Francisco vs Minnesota Prediction & Odds:
Free NFL Betting Insights for 9/15/24

The Week 2 matchup between the San Francisco 49ers and Minnesota Vikings is set to be a fascinating contest between two teams looking to solidify their strong starts to the 2024 season. The 49ers enter this game with a commanding Week 1 victory under their belt, showing both offensive firepower and defensive resilience. Led by quarterback Brock Purdy, who has consistently thrown for over 240 yards in each of his last six appearances as a favorite, the 49ers’ offense will rely heavily on the versatility of Christian McCaffrey. McCaffrey has recorded at least one touchdown in 20 of his last 21 appearances with the team, making him a constant threat both on the ground and through the air. The Vikings, on the other hand, are also looking strong after a convincing win against the New York Giants in Week 1.

Quarterback Sam Darnold, completing 79.2% of his passes, showed poise, and with weapons like Justin Jefferson and Jordan Addison, the Vikings’ passing game remains potent. The ground game, led by Aaron Jones, who rushed for 94 yards and a touchdown, adds another dimension to Minnesota’s offense. Defensively, the Vikings have been solid, allowing only six points in their opener, but they will face a much tougher test against the 49ers’ well-rounded offense. For the Vikings to have a chance, they need to contain McCaffrey and pressure Purdy into making mistakes. On the flip side, the 49ers’ defense, ranked among the best in the league, will focus on shutting down Darnold and forcing the Vikings to rely on their less-explosive running game. The game will likely come down to execution in the red zone and third-down conversions, areas where both teams have excelled this season. While the 49ers are favored, the Vikings’ home-field advantage and offensive capabilities make this a must-watch game.

San Francisco 49ers NFL Preview

The San Francisco 49ers enter Week 2 as one of the most formidable teams in the NFL. Coming off a dominant Week 1 victory where they looked like a well-oiled machine, the 49ers are favorites against the Minnesota Vikings. Brock Purdy, the 49ers’ young quarterback, has been efficient, and with weapons like Christian McCaffrey and George Kittle at his disposal, San Francisco’s offense is among the most balanced in the league. McCaffrey, who has scored at least one touchdown in 20 of his last 21 appearances, remains the focal point of the 49ers’ attack. Defensively, the 49ers are just as strong, boasting a deep and talented roster capable of pressuring opposing quarterbacks and stopping the run. The 49ers have a strong record as favorites, having won each of their last 10 games in that role before a division game. Their defense will focus on containing Sam Darnold and disrupting the Vikings’ rhythm, aiming to force turnovers and capitalize on any mistakes. Injuries are a concern for the 49ers, with several key players listed as questionable, including Christian McCaffrey. However, their depth and experience give them the edge in this matchup. If the 49ers can execute their game plan and avoid turnovers, they should come out on top in what promises to be an intense and closely contested game.

The San Francisco 49ers will face the Minnesota Vikings at U.S. Bank Stadium on September 15, 2024. The 49ers are coming off a dominant Week 1 performance, while the Vikings are also 1-0, aiming to continue their strong start to the season. The 49ers are favored to win, but the Vikings’ strong home performance could make this a competitive matchup. San Francisco vs Minnesota AI Prediction: Free NFL Betting Insights for Sep 15. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Minnesota Vikings NFL Preview

The Minnesota Vikings are off to a strong start in 2024 after a solid Week 1 win over the New York Giants, where they held their opponents to just six points. Sam Darnold led the offense efficiently, completing 79.2% of his passes for 208 yards, two touchdowns, and one interception. The Vikings will look to replicate that efficiency against the 49ers’ tough defense. Their ground game, anchored by Aaron Jones, who rushed for 94 yards and a touchdown, provides balance and a reliable option to keep the 49ers’ pass rush at bay. The Vikings’ defense, led by Byron Murphy Jr. with nine tackles and Pat Jones II with two sacks, will be critical in pressuring Brock Purdy and preventing big plays from the 49ers’ explosive offense. However, the Vikings have struggled ATS, failing to cover in six of their last seven games. They will need to improve their performance in key situations, particularly on third downs and in the red zone, where they currently excel. Without tight end T.J. Hockenson and with Jordan Addison questionable, the Vikings’ offensive depth will be tested. If they can leverage their home-field advantage and maintain their high conversion rates, they could pull off an upset against the favored 49ers

San Francisco vs. Minnesota Prop Picks (AI)

Remi is pouring through loads of data on each player. In fact, anytime the 49ers and Vikings play there’s always several intriguing angles to key in on. Not to mention games played at U.S. Bank Stadium in Sep almost always follow normal, predictable patterns.
Remi searched hard and crunched the numbers and found a prop bet for the San Francisco 49ers vs Minnesota Vikings matchup. Prop Bet: Brandon Aiyuk Over 4.5 Receptions

San Francisco vs. Minnesota Prediction (AI)

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Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every past game between the 49ers and Vikings and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.

Remi has been most watching on the linear correlation of factor knucklehead sportsbettors regularly put on San Francisco’s strength factors between a 49ers team going up against a possibly unhealthy Vikings team. In reality, the true game analytics appear to reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI San Francisco vs Minnesota picks, computer picks 49ers vs Vikings, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NFL 11/9 CLE@NYJ UNLOCK THIS PICK 7 VAULT v3 Locked VAULT v3
NFL 11/9 BAL@MIN UNLOCK THIS PICK 7 VAULT v4 Locked VAULT v4
NFL 11/9 DET@WAS UNLOCK THIS PICK 6 VAULT v3 Locked VAULT v3
NFL 11/9 NE@TB UNLOCK THIS PICK 6 VAULT v2 Locked VAULT v2
NFL 11/9 ARI@SEA UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
NFL 11/9 JAC@HOU UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
NFL 11/9 NYG@CHI UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
NFL 11/9 NO@CAR UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
NFL 11/9 JAC@HOU UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
NFL 11/9 PIT@LAC UNLOCK THIS PICK 3 INTEL Locked INTEL
NFL 11/9 LAR@SF GET FREE PICK NOW 2
NFL 11/9 PIT@LAC UNLOCK THIS PICK 1 INTEL Locked INTEL
NFL 11/9 ARI@SEA UNLOCK THIS PICK 10 INTEL Locked INTEL
NFL 11/9 NO@CAR UNLOCK THIS PICK 1 INTEL Locked INTEL
NFL 11/9 DET@WAS UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

49ers Betting Trends

The San Francisco 49ers have a strong record against the spread (ATS) as favorites, covering in eight of their last nine games against NFC opponents. They have also won each of their last 10 games as favorites before a division game, highlighting their ability to perform well when expected to win.

Vikings Betting Trends

The Minnesota Vikings have struggled ATS, failing to cover the spread in six of their last seven games. However, they have a strong 4th down conversion rate and red zone efficiency, ranking first in the NFL in both categories this season, which could play a crucial role in keeping the game close.

49ers vs. Vikings Matchup Trends

Seven of the 49ers’ last eight games as favorites following a win have gone over the total points line. Similarly, six of the Vikings’ last seven games as underdogs have also gone over the total points line. This trend suggests a higher-scoring game may be likely.

San Francisco vs. Minnesota Game Info

San Francisco vs Minnesota starts on September 15, 2024 at 1:00 PM EST.

Spread: Minnesota +6.0
Moneyline: San Francisco -265, Minnesota +216
Over/Under: 45.5

San Francisco: (1-0)  |  Minnesota: (1-0)

Remi searched hard and crunched the numbers and found a prop bet for the San Francisco 49ers vs Minnesota Vikings matchup. Prop Bet: Brandon Aiyuk Over 4.5 Receptions . Prices move—always shop for the best number.

Seven of the 49ers’ last eight games as favorites following a win have gone over the total points line. Similarly, six of the Vikings’ last seven games as underdogs have also gone over the total points line. This trend suggests a higher-scoring game may be likely.

SF trend: The San Francisco 49ers have a strong record against the spread (ATS) as favorites, covering in eight of their last nine games against NFC opponents. They have also won each of their last 10 games as favorites before a division game, highlighting their ability to perform well when expected to win.

MIN trend: The Minnesota Vikings have struggled ATS, failing to cover the spread in six of their last seven games. However, they have a strong 4th down conversion rate and red zone efficiency, ranking first in the NFL in both categories this season, which could play a crucial role in keeping the game close.

See our latest NFL picks and odds pages for 2024 to compare prices before you bet.

San Francisco vs. Minnesota Odds

AI algorithm Remi is pouring through tons of stats on each player. In fact, anytime the San Francisco vs Minnesota trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable patterns.

San Francisco vs Minnesota Opening Odds

SF Moneyline: -265
MIN Moneyline: +216
SF Spread: -6
MIN Spread: +6.0
Over/Under: 45.5

San Francisco vs Minnesota Live Odds

Games PTS ML SPR O/U
Nov 10, 2025 8:15PM EST
Philadelphia Eagles
Green Bay Packers
11/10/25 8:15PM
Eagles
Packers
-105
-115
+1.5 (-118)
-1.5 (-104)
O 45.5 (-110)
U 45.5 (-110)
Nov 13, 2025 8:15PM EST
New York Jets
New England Patriots
11/13/25 8:15PM
Jets
Patriots
+500
-700
+11.5 (-110)
-11.5 (-110)
O 43.5 (-110)
U 43.5 (-110)
Nov 16, 2025 9:30AM EST
Washington Commanders
Miami Dolphins
11/16/25 9:30AM
Commanders
Dolphins
+128
-152
+2.5 (-105)
-2.5 (-115)
O 47.5 (-104)
U 47.5 (-118)
Nov 16, 2025 1:00PM EST
Carolina Panthers
Atlanta Falcons
11/16/25 1PM
Panthers
Falcons
+176
-210
+3.5 (-105)
-3.5 (-115)
O 42.5 (-118)
U 42.5 (-104)
Nov 16, 2025 1:00PM EST
Chicago Bears
Minnesota Vikings
11/16/25 1PM
Bears
Vikings
+136
-162
+3 (-118)
-3 (-104)
O 47.5 (-120)
U 47.5 (-102)
Nov 16, 2025 1:00PM EST
Los Angeles Chargers
Jacksonville Jaguars
11/16/25 1PM
Chargers
Jaguars
-146
+126
-2.5 (-120)
+2.5 (-102)
O 43.5 (-115)
U 43.5 (-105)
Nov 16, 2025 1:00PM EST
Green Bay Packers
New York Giants
11/16/25 1PM
Packers
Giants
-460
+360
-7.5 (-120)
+7.5 (-102)
O 44.5 (-110)
U 44.5 (-110)
Nov 16, 2025 1:00PM EST
Cincinnati Bengals
Pittsburgh Steelers
11/16/25 1PM
Bengals
Steelers
+200
-245
+5.5 (-115)
-5.5 (-105)
O 50.5 (-105)
U 50.5 (-115)
Nov 16, 2025 1:00PM EST
Tampa Bay Buccaneers
Buffalo Bills
11/16/25 1PM
Buccaneers
Bills
+215
-260
+5.5 (-110)
-5.5 (-110)
O 49.5 (-110)
U 49.5 (-110)
Nov 16, 2025 1:00PM EST
Houston Texans
Tennessee Titans
11/16/25 1PM
Texans
Titans
-400
+315
-7.5 (-106)
+7.5 (-114)
O 39.5 (-105)
U 39.5 (-115)
Nov 16, 2025 4:05PM EST
San Francisco 49ers
Arizona Cardinals
11/16/25 4:05PM
49ers
Cardinals
-156
+132
-3 (-104)
+3 (-118)
O 48.5 (-115)
U 48.5 (-105)
Nov 16, 2025 4:05PM EST
Seattle Seahawks
Los Angeles Rams
11/16/25 4:05PM
Seahawks
Rams
+124
-146
+2.5 (-102)
-2.5 (-120)
O 48.5 (-108)
U 48.5 (-112)
Nov 16, 2025 4:25PM EST
Kansas City Chiefs
Denver Broncos
11/16/25 4:25PM
Chiefs
Broncos
-190
+160
-3.5 (-110)
+3.5 (-110)
O 44.5 (-105)
U 44.5 (-115)
Nov 16, 2025 4:25PM EST
Baltimore Ravens
Cleveland Browns
11/16/25 4:25PM
Ravens
Browns
-510
+390
-8.5 (-115)
+8.5 (-105)
O 41.5 (-115)
U 41.5 (-105)
Nov 16, 2025 8:20PM EST
Detroit Lions
Philadelphia Eagles
11/16/25 8:20PM
Lions
Eagles
+102
-120
+1.5 (-112)
-1.5 (-108)
O 48.5 (-110)
U 48.5 (-110)
Nov 17, 2025 8:15PM EST
Dallas Cowboys
Las Vegas Raiders
11/17/25 8:15PM
Cowboys
Raiders
-196
+164
-3.5 (-105)
+3.5 (-115)
O 50.5 (-110)
U 50.5 (-110)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Francisco 49ers vs. Minnesota Vikings on September 15, 2024 at U.S. Bank Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
LV@DEN RILEY MOSS OVER 4.5 TACKLE + ASST 54.8% 4 WIN
LV@DEN UNDER 43 53.4% 2 WIN
ARI@DAL BUDDA BAKER OVER 7.5 TACKLES + ASSTS 54.4% 4 WIN
ARI@DAL GEORGE PICKENS OVER 4.5 RECEPTIONS 56.6% 6 WIN
DEN@HOU WIL LUTZ OVER 1.5 MADE FIELD GOALS 54.2% 3 LOSS
SEA@WAS SEA -3 56.7% 6 WIN
IND@PIT IND -3 56.8% 6 LOSS
LAC@TEN LAC -9.5 56.2% 6 LOSS
CHI@CIN CHI -2.5 52.6% 2 WIN
SEA@WAS OVER 48 52.9% 2 WIN
SEA@WAS JAYDEN DANIELS OVER 20.5 PASS COMP 56.7% 6 LOSS
JAC@LV JAC -140 64.2% 7 WIN
NO@LAR LAR -14 55.0% 4 WIN
DEN@HOU HOU -1.5 54.2% 3 LOSS
CAR@GB GB -12.5 55.4% 5 LOSS
SF@NYG NYG +2.5 56.1% 5 LOSS
BAL@MIA TUA TAGOVAILOA UNDER 0.5 INT 55.3% 5 LOSS
TB@NO TB -3.5 52.3% 1 WIN
GB@PIT GB -2.5 52.3% 1 WIN
SF@HOU SF +2.5 56.0% 6 LOSS
NYG@PHI NYG +7.5 53.9% 3 LOSS
BUF@CAR CAR +7.5 54.2% 3 LOSS
DAL@DEN DAL +3.5 55.0% 4 LOSS
MIA@ATL MIA +7 54.3% 4 WIN
CLE@NE CLE +7 56.8% 6 LOSS
TB@NO BAKER MAYFIELD OVER 15.5 RUSH YDS 56.6% 6 LOSS
MIN@LAC JUSTIN HERBERT PASS ATT UNDER 35.5 55.5% 5 WIN
TB@DET TB +6.5 54.4% 4 LOSS
TB@DET RACHAAD WHITE UNDER 14.5 RUSH ATT 54.4% 4 WIN
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS