49ers vs. Vikings
Prediction, Odds & Props
Sep 15 | NFL AI Picks
Updated: 2024-09-08T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The San Francisco 49ers will face the Minnesota Vikings at U.S. Bank Stadium on September 15, 2024. The 49ers are coming off a dominant Week 1 performance, while the Vikings are also 1-0, aiming to continue their strong start to the season. The 49ers are favored to win, but the Vikings’ strong home performance could make this a competitive matchup.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 15, 2024
Start Time: 1:00 PM EST
Venue: U.S. Bank Stadium
Vikings Record: (1-0)
49ers Record: (1-0)
OPENING ODDS
SF Moneyline: -265
MIN Moneyline: +216
SF Spread: -6
MIN Spread: +6.0
Over/Under: 45.5
SF
Betting Trends
- The San Francisco 49ers have a strong record against the spread (ATS) as favorites, covering in eight of their last nine games against NFC opponents. They have also won each of their last 10 games as favorites before a division game, highlighting their ability to perform well when expected to win.
MIN
Betting Trends
- The Minnesota Vikings have struggled ATS, failing to cover the spread in six of their last seven games. However, they have a strong 4th down conversion rate and red zone efficiency, ranking first in the NFL in both categories this season, which could play a crucial role in keeping the game close.
MATCHUP TRENDS
- Seven of the 49ers’ last eight games as favorites following a win have gone over the total points line. Similarly, six of the Vikings’ last seven games as underdogs have also gone over the total points line. This trend suggests a higher-scoring game may be likely.
SF vs. MIN
Best Prop Bet
- Remi searched hard and crunched the numbers and found a prop bet for the San Francisco 49ers vs Minnesota Vikings matchup. Prop Bet: Brandon Aiyuk Over 4.5 Receptions
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San Francisco vs Minnesota Prediction & Odds:
Free NFL Betting Insights for 9/15/24
Quarterback Sam Darnold, completing 79.2% of his passes, showed poise, and with weapons like Justin Jefferson and Jordan Addison, the Vikings’ passing game remains potent. The ground game, led by Aaron Jones, who rushed for 94 yards and a touchdown, adds another dimension to Minnesota’s offense. Defensively, the Vikings have been solid, allowing only six points in their opener, but they will face a much tougher test against the 49ers’ well-rounded offense. For the Vikings to have a chance, they need to contain McCaffrey and pressure Purdy into making mistakes. On the flip side, the 49ers’ defense, ranked among the best in the league, will focus on shutting down Darnold and forcing the Vikings to rely on their less-explosive running game. The game will likely come down to execution in the red zone and third-down conversions, areas where both teams have excelled this season. While the 49ers are favored, the Vikings’ home-field advantage and offensive capabilities make this a must-watch game.
Wednesday's practice report for #INDvsGB: pic.twitter.com/HoJK4L4qJZ
— Indianapolis Colts (@Colts) September 11, 2024
San Francisco 49ers NFL Preview
The San Francisco 49ers enter Week 2 as one of the most formidable teams in the NFL. Coming off a dominant Week 1 victory where they looked like a well-oiled machine, the 49ers are favorites against the Minnesota Vikings. Brock Purdy, the 49ers’ young quarterback, has been efficient, and with weapons like Christian McCaffrey and George Kittle at his disposal, San Francisco’s offense is among the most balanced in the league. McCaffrey, who has scored at least one touchdown in 20 of his last 21 appearances, remains the focal point of the 49ers’ attack. Defensively, the 49ers are just as strong, boasting a deep and talented roster capable of pressuring opposing quarterbacks and stopping the run. The 49ers have a strong record as favorites, having won each of their last 10 games in that role before a division game. Their defense will focus on containing Sam Darnold and disrupting the Vikings’ rhythm, aiming to force turnovers and capitalize on any mistakes. Injuries are a concern for the 49ers, with several key players listed as questionable, including Christian McCaffrey. However, their depth and experience give them the edge in this matchup. If the 49ers can execute their game plan and avoid turnovers, they should come out on top in what promises to be an intense and closely contested game.
Credit: USA TODAY/IMAGN
Minnesota Vikings NFL Preview
The Minnesota Vikings are off to a strong start in 2024 after a solid Week 1 win over the New York Giants, where they held their opponents to just six points. Sam Darnold led the offense efficiently, completing 79.2% of his passes for 208 yards, two touchdowns, and one interception. The Vikings will look to replicate that efficiency against the 49ers’ tough defense. Their ground game, anchored by Aaron Jones, who rushed for 94 yards and a touchdown, provides balance and a reliable option to keep the 49ers’ pass rush at bay. The Vikings’ defense, led by Byron Murphy Jr. with nine tackles and Pat Jones II with two sacks, will be critical in pressuring Brock Purdy and preventing big plays from the 49ers’ explosive offense. However, the Vikings have struggled ATS, failing to cover in six of their last seven games. They will need to improve their performance in key situations, particularly on third downs and in the red zone, where they currently excel. Without tight end T.J. Hockenson and with Jordan Addison questionable, the Vikings’ offensive depth will be tested. If they can leverage their home-field advantage and maintain their high conversion rates, they could pull off an upset against the favored 49ers
Wednesday's practice report for #INDvsGB: pic.twitter.com/HoJK4L4qJZ
— Indianapolis Colts (@Colts) September 11, 2024
San Francisco vs. Minnesota Prop Picks (AI)
San Francisco vs. Minnesota Prediction (AI)
Remi, our AI sports wizard, has been pouring over millions of data from every angle between the 49ers and Vikings and using recursive machine learning and impressive AI to examine the data to a single cover probability.
Remi has been most watching on the trending emphasis emotional bettors often put on player performance factors between a 49ers team going up against a possibly rested Vikings team. We’ve found the true game analytics might reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI San Francisco vs Minnesota picks, computer picks 49ers vs Vikings, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
49ers Betting Trends
The San Francisco 49ers have a strong record against the spread (ATS) as favorites, covering in eight of their last nine games against NFC opponents. They have also won each of their last 10 games as favorites before a division game, highlighting their ability to perform well when expected to win.
Vikings Betting Trends
The Minnesota Vikings have struggled ATS, failing to cover the spread in six of their last seven games. However, they have a strong 4th down conversion rate and red zone efficiency, ranking first in the NFL in both categories this season, which could play a crucial role in keeping the game close.
49ers vs. Vikings Matchup Trends
Seven of the 49ers’ last eight games as favorites following a win have gone over the total points line. Similarly, six of the Vikings’ last seven games as underdogs have also gone over the total points line. This trend suggests a higher-scoring game may be likely.
San Francisco vs. Minnesota Game Info
What time does San Francisco vs Minnesota start on September 15, 2024?
San Francisco vs Minnesota starts on September 15, 2024 at 1:00 PM EST.
Where is San Francisco vs Minnesota being played?
Venue: U.S. Bank Stadium.
What are the opening odds for San Francisco vs Minnesota?
Spread: Minnesota +6.0
Moneyline: San Francisco -265, Minnesota +216
Over/Under: 45.5
What are the records for San Francisco vs Minnesota?
San Francisco: (1-0) | Minnesota: (1-0)
What is the AI best bet for San Francisco vs Minnesota?
Remi searched hard and crunched the numbers and found a prop bet for the San Francisco 49ers vs Minnesota Vikings matchup. Prop Bet: Brandon Aiyuk Over 4.5 Receptions . Prices move—always shop for the best number.
What are San Francisco vs Minnesota trending bets?
Seven of the 49ers’ last eight games as favorites following a win have gone over the total points line. Similarly, six of the Vikings’ last seven games as underdogs have also gone over the total points line. This trend suggests a higher-scoring game may be likely.
What are San Francisco trending bets?
SF trend: The San Francisco 49ers have a strong record against the spread (ATS) as favorites, covering in eight of their last nine games against NFC opponents. They have also won each of their last 10 games as favorites before a division game, highlighting their ability to perform well when expected to win.
What are Minnesota trending bets?
MIN trend: The Minnesota Vikings have struggled ATS, failing to cover the spread in six of their last seven games. However, they have a strong 4th down conversion rate and red zone efficiency, ranking first in the NFL in both categories this season, which could play a crucial role in keeping the game close.
Where can I find AI Picks for San Francisco vs Minnesota?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
San Francisco vs. Minnesota Odds
AI algorithm Remi is pouring through mountains of data on each line. In fact, anytime the San Francisco vs Minnesota trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable patterns.
San Francisco vs Minnesota Opening Odds
SF Moneyline:
-265 MIN Moneyline: +216
SF Spread: -6
MIN Spread: +6.0
Over/Under: 45.5
San Francisco vs Minnesota Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Sep 28, 2025 9:31AM EDT
Minnesota Vikings
Pittsburgh Steelers
9/28/25 9:31AM
Vikings
Steelers
|
–
–
|
-145
+125
|
-2 (-120)
+2 (+100)
|
O 41 (-110)
U 41 (-110)
|
|
|
Sep 28, 2025 1:00PM EDT
Cleveland Browns
Detroit Lions
9/28/25 1PM
Browns
Lions
|
–
–
|
+440
-575
|
+10 (-110)
-10 (-110)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Sep 28, 2025 1:00PM EDT
Los Angeles Chargers
New York Giants
9/28/25 1PM
Chargers
Giants
|
–
–
|
-300
+250
|
-6.5 (-105)
+6.5 (-115)
|
O 43.5 (-110)
U 43.5 (-110)
|
|
|
Sep 28, 2025 1:01PM EDT
Tennessee Titans
Houston Texans
9/28/25 1:01PM
Titans
Texans
|
–
–
|
+300
-375
|
+7 (-105)
-7 (-115)
|
O 39 (-110)
U 39 (-110)
|
|
|
Sep 28, 2025 1:01PM EDT
Philadelphia Eagles
Tampa Bay Buccaneers
9/28/25 1:01PM
Eagles
Buccaneers
|
–
–
|
-190
+163
|
-3.5 (-105)
+3.5 (-115)
|
O 44 (-110)
U 44 (-110)
|
|
|
Sep 28, 2025 1:01PM EDT
Washington Commanders
Atlanta Falcons
9/28/25 1:01PM
Commanders
Falcons
|
–
–
|
+115
-135
|
+1.5 (+100)
-1.5 (-120)
|
O 43.5 (-110)
U 43.5 (-110)
|
|
|
Sep 28, 2025 1:01PM EDT
New Orleans Saints
Buffalo Bills
9/28/25 1:01PM
Saints
Bills
|
–
–
|
+825
-1400
|
+14.5 (-110)
-14.5 (-110)
|
O 48 (-110)
U 48 (-110)
|
|
|
Sep 28, 2025 1:01PM EDT
Carolina Panthers
New England Patriots
9/28/25 1:01PM
Panthers
Patriots
|
–
–
|
+203
-240
|
+5 (-105)
-5 (-115)
|
O 43 (-110)
U 43 (-110)
|
|
|
Sep 28, 2025 4:06PM EDT
Jacksonville Jaguars
San Francisco 49ers
9/28/25 4:06PM
Jaguars
49ers
|
–
–
|
+150
-175
|
+3 (+100)
-3 (-120)
|
O 46.5 (-110)
U 46.5 (-110)
|
|
|
Sep 28, 2025 4:06PM EDT
Indianapolis Colts
Los Angeles Rams
9/28/25 4:06PM
Colts
Rams
|
–
–
|
+155
-180
|
+3.5 (-115)
-3.5 (-105)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
|
Sep 28, 2025 4:25PM EDT
Baltimore Ravens
Kansas City Chiefs
9/28/25 4:25PM
Ravens
Chiefs
|
–
–
|
-150
+129
|
-2.5 (-120)
+2.5 (+100)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
|
Sep 28, 2025 4:26PM EDT
Chicago Bears
Las Vegas Raiders
9/28/25 4:26PM
Bears
Raiders
|
–
–
|
+100
-120
|
pk
pk
|
O 48 (-110)
U 48 (-110)
|
|
|
Sep 28, 2025 8:21PM EDT
Green Bay Packers
Dallas Cowboys
9/28/25 8:21PM
Packers
Cowboys
|
–
–
|
-330
+270
|
-7 (+100)
+7 (-120)
|
O 46.5 (-110)
U 46.5 (-110)
|
|
|
Sep 29, 2025 7:16PM EDT
New York Jets
Miami Dolphins
9/29/25 7:16PM
Jets
Dolphins
|
–
–
|
+129
-150
|
+2.5 (+100)
-2.5 (-120)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Sep 29, 2025 8:16PM EDT
Cincinnati Bengals
Denver Broncos
9/29/25 8:16PM
Bengals
Broncos
|
–
–
|
+345
-440
|
+7.5 (-110)
-7.5 (-110)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Oct 2, 2025 7:16PM EDT
San Francisco 49ers
Los Angeles Rams
10/2/25 7:16PM
49ers
Rams
|
–
–
|
+135
-160
|
+3 (-110)
-3 (-110)
|
O 46.5 (-115)
U 46.5 (-105)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Francisco 49ers vs. Minnesota Vikings on September 15, 2024 at U.S. Bank Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |
| GB@CLE | GB -7 | 54.3% | 4 | LOSS |
| ARI@SF | ARI +3 | 57.7% | 6 | WIN |
| KC@NYG | PATRICK MAHOMES OVER 230.5 PASS YDS | 54.7% | 4 | WIN |
| GB@CLE | JOE FLACCO OVER 37.5 PASS ATT | 56.6% | 6 | LOSS |
| MIA@BUF | TYREEK HILL OVER 5.5 TOTAL RECEPTIONS | 56.8% | 6 | LOSS |
| LAC@LV | LAC -3 | 54.9% | 4 | WIN |
| TB@HOU | BAKER MAYFIELD OVER 1.5 PASS TDS | 54.4% | 4 | WIN |
| CHI@DET | DET -6.5 | 54.3% | 4 | WIN |
| DEN@IND | DEN -118 | 60.1% | 10 | LOSS |
| PHI@KC | PHI -115 | 56.7% | 6 | WIN |
| SF@NO | SF -3 | 58.8% | 8 | WIN |
| SEA@PIT | OVER 40 | 54.9% | 4 | WIN |
| CAR@ARI | BRYCE YOUNG INTERCEPTIONS UNDER 0.5 | 56.4% | 6 | LOSS |
| DEN@IND | JOSH DOWNS RECEPTIONS OVER 3.5 | 54.7% | 4 | WIN |
| ATL@MIN | BIJAN ROBINSON RUSH + REC YDS OVER 94.5 | 53.4% | 3 | WIN |
| WAS@GB | WAS +3.5 | 56.5% | 6 | LOSS |
| WAS@GB | JORDAN LOVE OVER 5.5 RUSH YDS | 54.7% | 4 | WIN |
| MIN@CHI | CALEB WILLIAMS OVER 219.5 PASS YDS | 53.4% | 3 | LOSS |
| TEN@DEN | DEN -8.5 | 55.3% | 5 | LOSS |
| SF@SEA | SF -115 | 54.6% | 4 | WIN |
| SF@SEA | KENNETH WALKER III UNDER 79.5 RUSH+REC YDS | 54.6% | 4 | WIN |
| CAR@JAC | TANK BIGSBY OVER 10.5 RUSH ATT | 56.1% | 6 | LOSS |
| KC@LAC | JUSTIN HERBERT UNDER 0.5 INT | 54.1% | 3 | WIN |
| DAL@PHI | GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS | 54.1% | 4 | LOSS |
| KC@PHI | JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS | 53.90% | 5 | WIN |
| KC@PHI | DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS | 54.40% | 6 | WIN |
| KC@PHI | PATRICK MAHOMES UNDER 68.3% PASS COMP | 55.00% | 8 | WIN |
| KC@PHI | JALEN HURTS LONGEST RUSH OVER 12.5 YDS | 55.60% | 8 | WIN |
| BUF@KC | DALTON KINCAID OVER 29.5 RECV YDS | 55.10% | 8 | LOSS |
| WAS@PHI | DEVONTA SMITH OVER 3.5 RECEPTIONS | 55.80% | 8 | WIN |
| BUF@KC | JAMES COOK ANYTIME TD | 53.00% | 5 | WIN |
| LAR@PHI | SAQUON BARKLEY UNDER 128 RUSH + REC YDS | 53.20% | 5 | LOSS |
| BAL@BUF | LAMAR JACKSON OVER 54.5 RUSH YDS | 54.50% | 6 | LOSS |
| HOU@KC | C.J. STROUD RUSH YDS UNDER 14.5 | 53.10% | 5 | LOSS |
| WAS@DET | JAMESON WILLIAMS RUSH YDS OVER 1.5 | 53.30% | 5 | WIN |
| WAS@DET | JARED GOFF PASS COMP % UNDER 72.3 | 54.30% | 6 | WIN |
| MIN@LAR | COOPER KUPP ANYTIME TOUCHDOWN | 52.60% | 3 | LOSS |
| MIN@LAR | MATTHEW STAFFORD OVER 21.5 PASS COMP | 54.10% | 6 | LOSS |
| WAS@TB | BRIAN ROBINSON JR OVER 1.5 REC TARGETS | 53.50% | 5 | WIN |
| WAS@TB | BAKER MAYFIELD UNDER 33.5 PASS ATT | 54.90% | 6 | WIN |
| GB@PHI | JALEN HURTS OVER 67.1 PASS COMP PERCENTAGE | 54.60% | 6 | LOSS |
| LAC@HOU | J.K. DOBBINS ANYTIME TD | 52.80% | 3 | LOSS |
| LAC@HOU | LAC -2.5 | 53.40% | 3 | LOSS |
| LAC@HOU | JUSTIN HERBERT OVER 19.5 RUSH YDS | 53.40% | 5 | LOSS |