Cardinals vs. Bills
Prediction, Odds & Props
Sep 08 | NFL AI Picks
Updated: 2024-09-01T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Arizona Cardinals will play the Buffalo Bills on September 8, 2024, at Highmark Stadium in Orchard Park, New York. This game features quarterbacks Kyler Murray for the Cardinals and Josh Allen for the Bills, with both teams looking to start the season with a win.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 08, 2024
Start Time: 1:00 PM EST​
Venue: Highmark Stadium​
Bills Record: (0-0)
Cardinals Record: (0-0)
OPENING ODDS
ARI Moneyline: +238
BUF Moneyline: -295
ARI Spread: +6.5
BUF Spread: -6.5
Over/Under: 48
ARI
Betting Trends
- The Cardinals have covered the spread in 1 of their last 5 games.
BUF
Betting Trends
- The Bills have covered the spread in 4 of their last 5 home games.
MATCHUP TRENDS
- Last season, Josh Allen led the Bills with 4,306 passing yards and 44 touchdowns, while Kyler Murray, despite missing games due to injury, recorded 1,799 passing yards and 13 touchdowns.
ARI vs. BUF
Best Prop Bet
- Remi searched and crunched the numbers and found a prop for this week's Cardinals vs Bills matchup: RB James Conner Over 11.5 Receiving Yards
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Arizona vs Buffalo Prediction & Odds:
Free NFL Betting Insights for 9/8/24
Our initial 53-man roster is set.
— Arizona Cardinals (@AZCardinals) August 27, 2024
Arizona Cardinals NFL Preview
The Cardinals finished 2023 with a 6-11 record. Kyler Murray is expected to lead the team after returning from injury, supported by James Conner and rookie wide receiver Marvin Harrison Jr. Defensively, the Cardinals allowed 26.8 points per game last season and will need significant improvement to compete with Buffalo’s offense.
Credit: USA TODAY/IMAGN
Buffalo Bills NFL Preview
The Bills ended the 2023 season with a 13-4 record. Josh Allen led a potent offense that averaged 244.4 passing yards and 130.1 rushing yards per game. The defense was among the best in the league, conceding only 18.3 points per game. Key players include defensive tackle Ed Oliver, who had 10 sacks last season, and linebacker Terrel Bernard, who recorded 143 tackles.
We’ve released 27 players from our roster. #BillsMafia
— Buffalo Bills (@BuffaloBills) August 27, 2024
More info: https://t.co/thw3Lw8Qh3 pic.twitter.com/COqUPeeBrM
Arizona vs. Buffalo Prop Picks (AI)
Arizona vs. Buffalo Prediction (AI)
Remi, our AI sports genius, has been pouring over mountains of data from every simulation between the Cardinals and Bills and using recursive machine learning and impressive AI to analyze the data to a single cover probability.
Remi has been most fixated on the trending weight knucklehead sportsbettors regularly put on Buffalo’s strength factors between a Cardinals team going up against a possibly improved Bills team. We’ve found the true game analytics appear to reflect a moderate lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Arizona vs Buffalo picks, computer picks Cardinals vs Bills, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Cardinals Betting Trends
The Cardinals have covered the spread in 1 of their last 5 games.
Bills Betting Trends
The Bills have covered the spread in 4 of their last 5 home games.
Cardinals vs. Bills Matchup Trends
Last season, Josh Allen led the Bills with 4,306 passing yards and 44 touchdowns, while Kyler Murray, despite missing games due to injury, recorded 1,799 passing yards and 13 touchdowns.
Arizona vs. Buffalo Game Info
What time does Arizona vs Buffalo start on September 08, 2024?
Arizona vs Buffalo starts on September 08, 2024 at 1:00 PM EST.
Where is Arizona vs Buffalo being played?
Venue: Highmark Stadium.
What are the opening odds for Arizona vs Buffalo?
Spread: Buffalo -6.5
Moneyline: Arizona +238, Buffalo -295
Over/Under: 48
What are the records for Arizona vs Buffalo?
Arizona: (0-0) Â |Â Buffalo: (0-0)
What is the AI best bet for Arizona vs Buffalo?
Remi searched and crunched the numbers and found a prop for this week's Cardinals vs Bills matchup: RB James Conner Over 11.5 Receiving Yards. Prices move—always shop for the best number.
What are Arizona vs Buffalo trending bets?
Last season, Josh Allen led the Bills with 4,306 passing yards and 44 touchdowns, while Kyler Murray, despite missing games due to injury, recorded 1,799 passing yards and 13 touchdowns.
What are Arizona trending bets?
ARI trend: The Cardinals have covered the spread in 1 of their last 5 games.
What are Buffalo trending bets?
BUF trend: The Bills have covered the spread in 4 of their last 5 home games.
Where can I find AI Picks for Arizona vs Buffalo?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
Arizona vs. Buffalo Odds
Remi is pouring through tons of data points on each line. In fact, anytime the Arizona vs Buffalo trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable patterns.
Arizona vs Buffalo Opening Odds
ARI Moneyline:
+238 BUF Moneyline: -295
ARI Spread: +6.5
BUF Spread: -6.5
Over/Under: 48
Arizona vs Buffalo Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
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Sep 28, 2025 9:31AM EDT
Minnesota Vikings
Pittsburgh Steelers
9/28/25 9:31AM
Vikings
Steelers
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–
–
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-140
+115
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-2.5 (-115)
+2.5 (-105)
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O 41 (-110)
U 41 (-110)
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Sep 28, 2025 1:00PM EDT
Cleveland Browns
Detroit Lions
9/28/25 1PM
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–
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+400
-550
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+10 (-110)
-10 (-110)
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O 44.5 (-105)
U 44.5 (-115)
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Sep 28, 2025 1:00PM EDT
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9/28/25 1PM
Chargers
Giants
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–
–
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-285
+230
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-6.5 (-105)
+6.5 (-115)
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O 44 (-110)
U 44 (-110)
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Sep 28, 2025 1:01PM EDT
Tennessee Titans
Houston Texans
9/28/25 1:01PM
Titans
Texans
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–
–
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+300
-375
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+7 (-105)
-7 (-115)
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O 39 (-110)
U 39 (-110)
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Sep 28, 2025 1:01PM EDT
Philadelphia Eagles
Tampa Bay Buccaneers
9/28/25 1:01PM
Eagles
Buccaneers
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–
–
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-190
+160
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-3.5 (-105)
+3.5 (-115)
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O 44 (-110)
U 44 (-110)
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Sep 28, 2025 1:01PM EDT
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Atlanta Falcons
9/28/25 1:01PM
Commanders
Falcons
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–
–
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+110
-130
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+2 (-110)
-2 (-110)
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O 43.5 (-110)
U 43.5 (-110)
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Sep 28, 2025 1:01PM EDT
New Orleans Saints
Buffalo Bills
9/28/25 1:01PM
Saints
Bills
|
–
–
|
+800
-1300
|
+15 (-110)
-15 (-110)
|
O 48 (-110)
U 48 (-110)
|
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Sep 28, 2025 1:01PM EDT
Carolina Panthers
New England Patriots
9/28/25 1:01PM
Panthers
Patriots
|
–
–
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+200
-250
|
+5.5 (-110)
-5.5 (-110)
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O 43 (-110)
U 43 (-110)
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Sep 28, 2025 4:06PM EDT
Jacksonville Jaguars
San Francisco 49ers
9/28/25 4:06PM
Jaguars
49ers
|
–
–
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+150
-180
|
+3.5 (-115)
-3.5 (-105)
|
O 46.5 (-110)
U 46.5 (-110)
|
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Sep 28, 2025 4:06PM EDT
Indianapolis Colts
Los Angeles Rams
9/28/25 4:06PM
Colts
Rams
|
–
–
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+160
-190
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+3.5 (-110)
-3.5 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
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Sep 28, 2025 4:25PM EDT
Baltimore Ravens
Kansas City Chiefs
9/28/25 4:25PM
Ravens
Chiefs
|
–
–
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-150
+125
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-2.5 (-120)
+2.5 (+100)
|
O 48.5 (-110)
U 48.5 (-110)
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Sep 28, 2025 4:26PM EDT
Chicago Bears
Las Vegas Raiders
9/28/25 4:26PM
Bears
Raiders
|
–
–
|
+100
-120
|
+1 (-110)
-1 (-110)
|
O 48 (-110)
U 48 (-110)
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Sep 28, 2025 8:21PM EDT
Green Bay Packers
Dallas Cowboys
9/28/25 8:21PM
Packers
Cowboys
|
–
–
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-325
+250
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-7 (-105)
+7 (-115)
|
O 47 (-110)
U 47 (-110)
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Sep 29, 2025 7:15PM EDT
New York Jets
Miami Dolphins
9/29/25 7:15PM
Jets
Dolphins
|
–
–
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+125
-150
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+3 (-115)
-3 (-105)
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O 44.5 (-110)
U 44.5 (-110)
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Sep 29, 2025 8:15PM EDT
Cincinnati Bengals
Denver Broncos
9/29/25 8:15PM
Bengals
Broncos
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–
–
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+310
-400
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+7.5 (-110)
-7.5 (-110)
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O 44 (-110)
U 44 (-110)
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Oct 2, 2025 8:16PM EDT
San Francisco 49ers
Los Angeles Rams
10/2/25 8:16PM
49ers
Rams
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–
–
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+134
-158
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+3 (-105)
-3 (-115)
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O 47 (-110)
U 47 (-110)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Arizona Cardinals vs. Buffalo Bills on September 08, 2024 at Highmark Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
   LEAN |    %WIN |    UNITS | RESULT |
|---|---|---|---|---|
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |
| GB@CLE | GB -7 | 54.3% | 4 | LOSS |
| ARI@SF | ARI +3 | 57.7% | 6 | WIN |
| KC@NYG | PATRICK MAHOMES OVER 230.5 PASS YDS | 54.7% | 4 | WIN |
| GB@CLE | JOE FLACCO OVER 37.5 PASS ATT | 56.6% | 6 | LOSS |
| MIA@BUF | TYREEK HILL OVER 5.5 TOTAL RECEPTIONS | 56.8% | 6 | LOSS |
| LAC@LV | LAC -3 | 54.9% | 4 | WIN |
| TB@HOU | BAKER MAYFIELD OVER 1.5 PASS TDS | 54.4% | 4 | WIN |
| CHI@DET | DET -6.5 | 54.3% | 4 | WIN |
| DEN@IND | DEN -118 | 60.1% | 10 | LOSS |
| PHI@KC | PHI -115 | 56.7% | 6 | WIN |
| SF@NO | SF -3 | 58.8% | 8 | WIN |
| SEA@PIT | OVER 40 | 54.9% | 4 | WIN |
| CAR@ARI | BRYCE YOUNG INTERCEPTIONS UNDER 0.5 | 56.4% | 6 | LOSS |
| DEN@IND | JOSH DOWNS RECEPTIONS OVER 3.5 | 54.7% | 4 | WIN |
| ATL@MIN | BIJAN ROBINSON RUSH + REC YDS OVER 94.5 | 53.4% | 3 | WIN |
| WAS@GB | WAS +3.5 | 56.5% | 6 | LOSS |
| WAS@GB | JORDAN LOVE OVER 5.5 RUSH YDS | 54.7% | 4 | WIN |
| MIN@CHI | CALEB WILLIAMS OVER 219.5 PASS YDS | 53.4% | 3 | LOSS |
| TEN@DEN | DEN -8.5 | 55.3% | 5 | LOSS |
| SF@SEA | SF -115 | 54.6% | 4 | WIN |
| SF@SEA | KENNETH WALKER III UNDER 79.5 RUSH+REC YDS | 54.6% | 4 | WIN |
| CAR@JAC | TANK BIGSBY OVER 10.5 RUSH ATT | 56.1% | 6 | LOSS |
| KC@LAC | JUSTIN HERBERT UNDER 0.5 INT | 54.1% | 3 | WIN |
| DAL@PHI | GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS | 54.1% | 4 | LOSS |
| KC@PHI | JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS | 53.90% | 5 | WIN |
| KC@PHI | DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS | 54.40% | 6 | WIN |
| KC@PHI | PATRICK MAHOMES UNDER 68.3% PASS COMP | 55.00% | 8 | WIN |
| KC@PHI | JALEN HURTS LONGEST RUSH OVER 12.5 YDS | 55.60% | 8 | WIN |
| BUF@KC | DALTON KINCAID OVER 29.5 RECV YDS | 55.10% | 8 | LOSS |
| WAS@PHI | DEVONTA SMITH OVER 3.5 RECEPTIONS | 55.80% | 8 | WIN |
| BUF@KC | JAMES COOK ANYTIME TD | 53.00% | 5 | WIN |
| LAR@PHI | SAQUON BARKLEY UNDER 128 RUSH + REC YDS | 53.20% | 5 | LOSS |
| BAL@BUF | LAMAR JACKSON OVER 54.5 RUSH YDS | 54.50% | 6 | LOSS |
| HOU@KC | C.J. STROUD RUSH YDS UNDER 14.5 | 53.10% | 5 | LOSS |
| WAS@DET | JAMESON WILLIAMS RUSH YDS OVER 1.5 | 53.30% | 5 | WIN |
| WAS@DET | JARED GOFF PASS COMP % UNDER 72.3 | 54.30% | 6 | WIN |
| MIN@LAR | COOPER KUPP ANYTIME TOUCHDOWN | 52.60% | 3 | LOSS |
| MIN@LAR | MATTHEW STAFFORD OVER 21.5 PASS COMP | 54.10% | 6 | LOSS |
| WAS@TB | BRIAN ROBINSON JR OVER 1.5 REC TARGETS | 53.50% | 5 | WIN |
| WAS@TB | BAKER MAYFIELD UNDER 33.5 PASS ATT | 54.90% | 6 | WIN |
| GB@PHI | JALEN HURTS OVER 67.1 PASS COMP PERCENTAGE | 54.60% | 6 | LOSS |
| LAC@HOU | J.K. DOBBINS ANYTIME TD | 52.80% | 3 | LOSS |
| LAC@HOU | LAC -2.5 | 53.40% | 3 | LOSS |
| LAC@HOU | JUSTIN HERBERT OVER 19.5 RUSH YDS | 53.40% | 5 | LOSS |