Cardinals vs Bills Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 08)
Updated: 2024-09-01T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Arizona Cardinals will play the Buffalo Bills on September 8, 2024, at Highmark Stadium in Orchard Park, New York. This game features quarterbacks Kyler Murray for the Cardinals and Josh Allen for the Bills, with both teams looking to start the season with a win.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 08, 2024
Start Time: 1:00 PM EST
Venue: Highmark Stadium
Bills Record: (0-0)
Cardinals Record: (0-0)
OPENING ODDS
ARI Moneyline: +238
BUF Moneyline: -295
ARI Spread: +6.5
BUF Spread: -6.5
Over/Under: 48
ARI
Betting Trends
- The Cardinals have covered the spread in 1 of their last 5 games.
BUF
Betting Trends
- The Bills have covered the spread in 4 of their last 5 home games.
MATCHUP TRENDS
- Last season, Josh Allen led the Bills with 4,306 passing yards and 44 touchdowns, while Kyler Murray, despite missing games due to injury, recorded 1,799 passing yards and 13 touchdowns.
ARI vs. BUF
Best Prop Bet
- Remi searched and crunched the numbers and found a prop for this week's Cardinals vs Bills matchup: RB James Conner Over 11.5 Receiving Yards
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Arizona vs Buffalo Prediction & Odds:
Free NFL Betting Insights for 9/8/24
Our initial 53-man roster is set.
— Arizona Cardinals (@AZCardinals) August 27, 2024
Arizona Cardinals NFL Preview
The Cardinals finished 2023 with a 6-11 record. Kyler Murray is expected to lead the team after returning from injury, supported by James Conner and rookie wide receiver Marvin Harrison Jr. Defensively, the Cardinals allowed 26.8 points per game last season and will need significant improvement to compete with Buffalo’s offense.
Credit: USA TODAY/IMAGN
Buffalo Bills NFL Preview
The Bills ended the 2023 season with a 13-4 record. Josh Allen led a potent offense that averaged 244.4 passing yards and 130.1 rushing yards per game. The defense was among the best in the league, conceding only 18.3 points per game. Key players include defensive tackle Ed Oliver, who had 10 sacks last season, and linebacker Terrel Bernard, who recorded 143 tackles.
We’ve released 27 players from our roster. #BillsMafia
— Buffalo Bills (@BuffaloBills) August 27, 2024
More info: https://t.co/thw3Lw8Qh3 pic.twitter.com/COqUPeeBrM
Arizona vs. Buffalo Prop Picks (AI)
Arizona vs. Buffalo Prediction (AI)
Remi, our AI sports wizard, has been pouring over mountains of data from every angle between the Cardinals and Bills and using recursive machine learning and impressive AI to analyze the data to a single cover probability.
Remi has been most fixated on the trending weight emotional bettors tend to put on coaching factors between a Cardinals team going up against a possibly unhealthy Bills team. It appears the true game analytics might reflect a moderate lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Arizona vs Buffalo picks, computer picks Cardinals vs Bills, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 5 |
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
EXECUTIVE
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 4 |
EXECUTIVE
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 1 |
INTEL
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| NFL | 10/20 | HOU@SEA | UNLOCK THIS PICK | 0 |
INTEL
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| NFL | 10/20 | TB@DET | UNLOCK THIS PICK | 0 |
INTEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Cardinals Betting Trends
The Cardinals have covered the spread in 1 of their last 5 games.
Bills Betting Trends
The Bills have covered the spread in 4 of their last 5 home games.
Cardinals vs. Bills Matchup Trends
Last season, Josh Allen led the Bills with 4,306 passing yards and 44 touchdowns, while Kyler Murray, despite missing games due to injury, recorded 1,799 passing yards and 13 touchdowns.
Arizona vs. Buffalo Game Info
What time does Arizona vs Buffalo start on September 08, 2024?
Arizona vs Buffalo starts on September 08, 2024 at 1:00 PM EST.
Where is Arizona vs Buffalo being played?
Venue: Highmark Stadium.
What are the opening odds for Arizona vs Buffalo?
Spread: Buffalo -6.5
Moneyline: Arizona +238, Buffalo -295
Over/Under: 48
What are the records for Arizona vs Buffalo?
Arizona: (0-0) | Buffalo: (0-0)
What is the AI best bet for Arizona vs Buffalo?
Remi searched and crunched the numbers and found a prop for this week's Cardinals vs Bills matchup: RB James Conner Over 11.5 Receiving Yards. Prices move—always shop for the best number.
What are Arizona vs Buffalo trending bets?
Last season, Josh Allen led the Bills with 4,306 passing yards and 44 touchdowns, while Kyler Murray, despite missing games due to injury, recorded 1,799 passing yards and 13 touchdowns.
What are Arizona trending bets?
ARI trend: The Cardinals have covered the spread in 1 of their last 5 games.
What are Buffalo trending bets?
BUF trend: The Bills have covered the spread in 4 of their last 5 home games.
Where can I find AI Picks for Arizona vs Buffalo?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
Arizona vs. Buffalo Odds
AI algorithm Remi is pouring through tons of data on each player. In fact, anytime the Arizona vs Buffalo trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable patterns.
Arizona vs Buffalo Opening Odds
ARI Moneyline:
+238 BUF Moneyline: -295
ARI Spread: +6.5
BUF Spread: -6.5
Over/Under: 48
Arizona vs Buffalo Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Oct 23, 2025 8:15PM EDT
Minnesota Vikings
Los Angeles Chargers
10/23/25 8:15PM
Vikings
Chargers
|
–
–
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+144
-172
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+3 (-105)
-3 (-115)
|
O 44.5 (-112)
U 44.5 (-108)
|
|
|
Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
|
–
–
|
+290
-360
|
+7 (-114)
-7 (-106)
|
O 40.5 (-105)
U 40.5 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
|
–
–
|
-430
+340
|
-7.5 (-110)
+7.5 (-110)
|
O 46.5 (-105)
U 46.5 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
|
–
–
|
+245
-300
|
+6.5 (-110)
-6.5 (-110)
|
O 43.5 (-115)
U 43.5 (-105)
|
|
|
Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
|
–
–
|
+265
-330
|
+6.5 (-106)
-6.5 (-114)
|
O 50.5 (-105)
U 50.5 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
|
–
–
|
+270
-335
|
+7 (-108)
-7 (-112)
|
O 43.5 (-105)
U 43.5 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
|
–
–
|
-108
-108
|
+1.5 (-120)
-1.5 (-102)
|
O 41.5 (-105)
U 41.5 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
|
–
–
|
+280
-350
|
+7.5 (-122)
-7.5 (+100)
|
O 44.5 (-114)
U 44.5 (-106)
|
|
|
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
|
–
–
|
-235
+194
|
-4.5 (-112)
+4.5 (-108)
|
O 46.5 (-114)
U 46.5 (-106)
|
|
|
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
|
–
–
|
+146
-174
|
+3.5 (-118)
-3.5 (-104)
|
O 49.5 (-120)
U 49.5 (-102)
|
|
|
Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
|
–
–
|
+750
-1200
|
+14.5 (-118)
-14.5 (-104)
|
O 46.5 (-114)
U 46.5 (-106)
|
|
|
Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
|
–
–
|
-174
+146
|
-3.5 (-104)
+3.5 (-118)
|
O 44.5 (-115)
U 44.5 (-105)
|
|
|
Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
|
–
–
|
+430
-590
|
+10.5 (-110)
-10.5 (-110)
|
O 47.5 (-110)
U 47.5 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Arizona Cardinals vs. Buffalo Bills on September 08, 2024 at Highmark Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
| CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
| PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
| GB@ARI | ARI +7 | 54.8% | 5 | WIN |
| NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
| WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
| GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
| PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
| BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
| CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
| TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
| DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
| SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
| LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
| ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
| TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
| LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
| SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
| CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
| DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
| KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
| KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
| HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
| DET@CIN | DET -10 | 55.6% | 5 | WIN |
| DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
| TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
| TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
| DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
| MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
| LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
| SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
| NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
| CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
| NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
| CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
| NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
| CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
| WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
| BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
| TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
| LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
| NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
| GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
| CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |