Cardinals vs Bills Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 08)
Updated: 2024-09-01T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Arizona Cardinals will play the Buffalo Bills on September 8, 2024, at Highmark Stadium in Orchard Park, New York. This game features quarterbacks Kyler Murray for the Cardinals and Josh Allen for the Bills, with both teams looking to start the season with a win.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 08, 2024
Start Time: 1:00 PM EST
Venue: Highmark Stadium
Bills Record: (0-0)
Cardinals Record: (0-0)
OPENING ODDS
ARI Moneyline: +238
BUF Moneyline: -295
ARI Spread: +6.5
BUF Spread: -6.5
Over/Under: 48
ARI
Betting Trends
- The Cardinals have covered the spread in 1 of their last 5 games.
BUF
Betting Trends
- The Bills have covered the spread in 4 of their last 5 home games.
MATCHUP TRENDS
- Last season, Josh Allen led the Bills with 4,306 passing yards and 44 touchdowns, while Kyler Murray, despite missing games due to injury, recorded 1,799 passing yards and 13 touchdowns.
ARI vs. BUF
Best Prop Bet
- Remi searched and crunched the numbers and found a prop for this week's Cardinals vs Bills matchup: RB James Conner Over 11.5 Receiving Yards
LIVE NFL ODDS
NFL ODDS COMPARISON
WANT MORE AI PICKS?
NET UNITS (INCL VIG)
NET PROFIT (INCL VIG) $100/UNIT
NET UNITS (INCL VIG)
NET PROFIT (INCL VIG) $100/UNIT
AI SPORTS PICK PRODUCTS
Create a Free Account
‘Create an Account’ to Get Remi’s Picks Today. Remi Finds New Picks
Remi calculates the probability a team will cover the line. Remi Works 24/7
Remi uses this probability to assign units to each pick.
Get Remi's AI Picks
Get Remi’s Top AI Sports Picks sent direct to your inbox.
Hedge Meaning in Betting | 4 Obvious Times to Hedge
Learn about hedge betting to manage risk and secure profits. Understand...
What is a Push in Betting? | 3 Ways To Use To Your Advantage
Understand what a push in betting means, how it happens in...
What Does the + and – Mean in Sports Betting? | 5 Easy Tips
Learn the basics of sports betting odds, what the plus (+)...
Arizona vs Buffalo Prediction & Odds:
Free NFL Betting Insights for 9/8/24
Our initial 53-man roster is set.
— Arizona Cardinals (@AZCardinals) August 27, 2024
Arizona Cardinals NFL Preview
The Cardinals finished 2023 with a 6-11 record. Kyler Murray is expected to lead the team after returning from injury, supported by James Conner and rookie wide receiver Marvin Harrison Jr. Defensively, the Cardinals allowed 26.8 points per game last season and will need significant improvement to compete with Buffalo’s offense.
Credit: USA TODAY/IMAGN
Buffalo Bills NFL Preview
The Bills ended the 2023 season with a 13-4 record. Josh Allen led a potent offense that averaged 244.4 passing yards and 130.1 rushing yards per game. The defense was among the best in the league, conceding only 18.3 points per game. Key players include defensive tackle Ed Oliver, who had 10 sacks last season, and linebacker Terrel Bernard, who recorded 143 tackles.
We’ve released 27 players from our roster. #BillsMafia
— Buffalo Bills (@BuffaloBills) August 27, 2024
More info: https://t.co/thw3Lw8Qh3 pic.twitter.com/COqUPeeBrM
Arizona vs. Buffalo Prop Picks (AI)
Arizona vs. Buffalo Prediction (AI)
Remi, our AI sports algorithm, has been pouring over tons of data from every past game between the Cardinals and Bills and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most focused on the trending factor human bettors regularly put on Arizona’s strength factors between a Cardinals team going up against a possibly deflated Bills team. It appears the true game analytics appear to reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Arizona vs Buffalo picks, computer picks Cardinals vs Bills, best bets, model edges, confidence ratings.
 |
DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
|---|---|---|---|---|---|---|
| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 6 |
VAULT v3
|
|
| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 4 |
EXECUTIVE
|
|
| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 4 |
EXECUTIVE
|
|
| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 1 |
INTEL
|
|
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Cardinals Betting Trends
The Cardinals have covered the spread in 1 of their last 5 games.
Bills Betting Trends
The Bills have covered the spread in 4 of their last 5 home games.
Cardinals vs. Bills Matchup Trends
Last season, Josh Allen led the Bills with 4,306 passing yards and 44 touchdowns, while Kyler Murray, despite missing games due to injury, recorded 1,799 passing yards and 13 touchdowns.
Arizona vs. Buffalo Game Info
What time does Arizona vs Buffalo start on September 08, 2024?
Arizona vs Buffalo starts on September 08, 2024 at 1:00 PM EST.
Where is Arizona vs Buffalo being played?
Venue: Highmark Stadium.
What are the opening odds for Arizona vs Buffalo?
Spread: Buffalo -6.5
Moneyline: Arizona +238, Buffalo -295
Over/Under: 48
What are the records for Arizona vs Buffalo?
Arizona: (0-0) | Buffalo: (0-0)
What is the AI best bet for Arizona vs Buffalo?
Remi searched and crunched the numbers and found a prop for this week's Cardinals vs Bills matchup: RB James Conner Over 11.5 Receiving Yards. Prices move—always shop for the best number.
What are Arizona vs Buffalo trending bets?
Last season, Josh Allen led the Bills with 4,306 passing yards and 44 touchdowns, while Kyler Murray, despite missing games due to injury, recorded 1,799 passing yards and 13 touchdowns.
What are Arizona trending bets?
ARI trend: The Cardinals have covered the spread in 1 of their last 5 games.
What are Buffalo trending bets?
BUF trend: The Bills have covered the spread in 4 of their last 5 home games.
Where can I find AI Picks for Arizona vs Buffalo?
See our latest NFL picks and odds pages for 2024 to compare prices before you bet.
Arizona vs. Buffalo Odds
AI algorithm Remi is pouring through tons of stats on each team. In fact, anytime the Arizona vs Buffalo trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps rarely follow normal, predictable betting trends.
Arizona vs Buffalo Opening Odds
ARI Moneyline:
+238 BUF Moneyline: -295
ARI Spread: +6.5
BUF Spread: -6.5
Over/Under: 48
Arizona vs Buffalo Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
In Progress
Philadelphia Eagles
Green Bay Packers
In Progress
Eagles
Packers
|
0
0
|
-105
-115
|
-2.5 (-105)
+2.5 (-125)
|
O 22.5 (-105)
U 22.5 (-125)
|
|
|
Nov 13, 2025 8:15PM EST
New York Jets
New England Patriots
11/13/25 8:15PM
Jets
Patriots
|
–
–
|
+525
-800
|
+11.5 (-115)
-11.5 (-107)
|
O 43.5 (-102)
U 43.5 (-120)
|
|
|
Nov 16, 2025 9:30AM EST
Washington Commanders
Miami Dolphins
11/16/25 9:30AM
Commanders
Dolphins
|
–
–
|
+125
-152
|
+2.5 (+100)
-2.5 (-121)
|
O 47.5 (-108)
U 47.5 (-112)
|
|
|
Nov 16, 2025 1:00PM EST
Carolina Panthers
Atlanta Falcons
11/16/25 1PM
Panthers
Falcons
|
–
–
|
+165
-200
|
+3.5 (-108)
-3.5 (-113)
|
O 42.5 (-112)
U 42.5 (-108)
|
|
|
Nov 16, 2025 1:00PM EST
Chicago Bears
Minnesota Vikings
11/16/25 1PM
Bears
Vikings
|
–
–
|
+137
-170
|
+3 (-112)
-3 (-109)
|
O 48.5 (-109)
U 48.5 (-110)
|
|
|
Nov 16, 2025 1:00PM EST
Los Angeles Chargers
Jacksonville Jaguars
11/16/25 1PM
Chargers
Jaguars
|
–
–
|
-152
+125
|
-3 (-108)
+3 (-113)
|
O 44 (-110)
U 44 (-109)
|
|
|
Nov 16, 2025 1:00PM EST
Cincinnati Bengals
Pittsburgh Steelers
11/16/25 1PM
Bengals
Steelers
|
–
–
|
+197
-245
|
+5.5 (-115)
-5.5 (-106)
|
O 49 (-112)
U 49 (-108)
|
|
|
Nov 16, 2025 1:00PM EST
Tampa Bay Buccaneers
Buffalo Bills
11/16/25 1PM
Buccaneers
Bills
|
–
–
|
+210
-265
|
+5.5 (-112)
-5.5 (-108)
|
O 49 (-113)
U 49 (-108)
|
|
|
Nov 16, 2025 1:00PM EST
Houston Texans
Tennessee Titans
11/16/25 1PM
Texans
Titans
|
–
–
|
-390
+295
|
-7.5 (-105)
+7.5 (-115)
|
O 39.5 (-107)
U 39.5 (-113)
|
|
|
Nov 16, 2025 4:05PM EST
San Francisco 49ers
Arizona Cardinals
11/16/25 4:05PM
49ers
Cardinals
|
–
–
|
-150
+125
|
-2.5 (-114)
+2.5 (-107)
|
O 49 (-110)
U 49 (-110)
|
|
|
Nov 16, 2025 4:05PM EST
Seattle Seahawks
Los Angeles Rams
11/16/25 4:05PM
Seahawks
Rams
|
–
–
|
+124
-150
|
+2.5 (-106)
-2.5 (-115)
|
O 48.5 (-108)
U 48.5 (-112)
|
|
|
Nov 16, 2025 4:25PM EST
Kansas City Chiefs
Denver Broncos
11/16/25 4:25PM
Chiefs
Broncos
|
–
–
|
-200
+164
|
-3.5 (-114)
+3.5 (-107)
|
O 44.5 (-109)
U 44.5 (-110)
|
|
|
Nov 16, 2025 4:25PM EST
Baltimore Ravens
Cleveland Browns
11/16/25 4:25PM
Ravens
Browns
|
–
–
|
-460
+340
|
-8.5 (-108)
+8.5 (-113)
|
O 41.5 (-109)
U 41.5 (-110)
|
|
|
Nov 17, 2025 8:15PM EST
Dallas Cowboys
Las Vegas Raiders
11/17/25 8:15PM
Cowboys
Raiders
|
–
–
|
-190
+156
|
-3.5 (-108)
+3.5 (-113)
|
O 50.5 (-110)
U 50.5 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Arizona Cardinals vs. Buffalo Bills on September 08, 2024 at Highmark Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| LV@DEN | RILEY MOSS OVER 4.5 TACKLE + ASST | 54.8% | 4 | WIN |
| LV@DEN | UNDER 43 | 53.4% | 2 | WIN |
| ARI@DAL | BUDDA BAKER OVER 7.5 TACKLES + ASSTS | 54.4% | 4 | WIN |
| ARI@DAL | GEORGE PICKENS OVER 4.5 RECEPTIONS | 56.6% | 6 | WIN |
| DEN@HOU | WIL LUTZ OVER 1.5 MADE FIELD GOALS | 54.2% | 3 | LOSS |
| SEA@WAS | SEA -3 | 56.7% | 6 | WIN |
| IND@PIT | IND -3 | 56.8% | 6 | LOSS |
| LAC@TEN | LAC -9.5 | 56.2% | 6 | LOSS |
| CHI@CIN | CHI -2.5 | 52.6% | 2 | WIN |
| SEA@WAS | OVER 48 | 52.9% | 2 | WIN |
| SEA@WAS | JAYDEN DANIELS OVER 20.5 PASS COMP | 56.7% | 6 | LOSS |
| JAC@LV | JAC -140 | 64.2% | 7 | WIN |
| NO@LAR | LAR -14 | 55.0% | 4 | WIN |
| DEN@HOU | HOU -1.5 | 54.2% | 3 | LOSS |
| CAR@GB | GB -12.5 | 55.4% | 5 | LOSS |
| SF@NYG | NYG +2.5 | 56.1% | 5 | LOSS |
| BAL@MIA | TUA TAGOVAILOA UNDER 0.5 INT | 55.3% | 5 | LOSS |
| TB@NO | TB -3.5 | 52.3% | 1 | WIN |
| GB@PIT | GB -2.5 | 52.3% | 1 | WIN |
| SF@HOU | SF +2.5 | 56.0% | 6 | LOSS |
| NYG@PHI | NYG +7.5 | 53.9% | 3 | LOSS |
| BUF@CAR | CAR +7.5 | 54.2% | 3 | LOSS |
| DAL@DEN | DAL +3.5 | 55.0% | 4 | LOSS |
| MIA@ATL | MIA +7 | 54.3% | 4 | WIN |
| CLE@NE | CLE +7 | 56.8% | 6 | LOSS |
| TB@NO | BAKER MAYFIELD OVER 15.5 RUSH YDS | 56.6% | 6 | LOSS |
| MIN@LAC | JUSTIN HERBERT PASS ATT UNDER 35.5 | 55.5% | 5 | WIN |
| TB@DET | TB +6.5 | 54.4% | 4 | LOSS |
| TB@DET | RACHAAD WHITE UNDER 14.5 RUSH ATT | 54.4% | 4 | WIN |
| NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
| CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
| PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
| GB@ARI | ARI +7 | 54.8% | 5 | WIN |
| NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
| WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
| GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
| PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
| BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
| CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
| TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
| DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
| SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
| LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
| ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
| TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
| LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
| SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
| CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
| DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
| KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
| KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |