AI NFL Picks — Week 6 (2025)
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Week 6 of the 2025 NFL season arrives with playoff implications already taking shape and several heavyweight clashes that could redefine the league’s balance of power — and our AI picks are dialed in on the matchups that matter most. In the AFC, Patrick Mahomes and the Kansas City Chiefs face a defensive gauntlet in the Baltimore Ravens, whose pass rush has been relentless under Mike Macdonald, forcing turnovers at a league-leading rate. Meanwhile, Joe Burrow and the Bengals look to regain footing against a surging Texans team led by C.J. Stroud, whose precision and poise have Houston quietly positioning itself as a legitimate contender in the AFC South. In the NFC, Dak Prescott and the Dallas Cowboys head to San Francisco to take on Brock Purdy and the 49ers in what feels like an early postseason preview — a collision of Dallas’ high-efficiency offense and San Francisco’s elite defensive front. From offensive efficiency metrics to injury-adjusted defensive grades, Week 6 offers data-driven bettors a buffet of high-leverage opportunities. Can Caleb Williams and the Bears build on their explosive start against Detroit’s top-five run defense? Will the Eagles’ offensive line hold up against a rejuvenated Jets pass rush led by Quinnen Williams? With key divisional duels, quarterback battles, and revenge narratives across the slate, Week 6 promises fireworks, volatility, and betting value in every window — and our AI models are breaking down every EPA trend, red-zone rate, and pressure split to find the smartest edges before kickoff.
Week 6 of the 2025 NFL season delivers a perfect storm of rivalry tension, playoff positioning, and data-driven intrigue — and our AI models are already flagging several games where analytics and emotion collide. The Buffalo Bills and Miami Dolphins headline the slate in an AFC East showdown that could tilt the division race, with Josh Allen’s aggressiveness clashing against a Miami secondary ranked top-five in EPA per dropback allowed. Over in the NFC, Jordan Love and the Green Bay Packers face the daunting task of solving Detroit’s top-ranked run defense, while rookie sensation Drake Maye and the New England Patriots get their toughest test yet against the relentless pressure of Myles Garrett and the Cleveland Browns. In Los Angeles, Justin Herbert and the Chargers will try to outduel Joe Burrow’s Bengals in what shapes up as one of the week’s highest-total games, pairing two offenses that rank top-10 in success rate but have struggled to finish drives in the red zone. Every year, Week 6 serves as the first true “separation Sunday,” where teams either confirm their contender status or slide toward midseason desperation. Dallas travels to face Philadelphia in another chapter of their storied NFC East rivalry — a matchup where Dak Prescott’s quick passing attack meets Jalen Carter and the league’s most disruptive front. Meanwhile, Lamar Jackson and the Ravens look to maintain control in the AFC North against a hungry Steelers team that continues to punch above its offensive metrics behind T.J. Watt’s defensive dominance. With advanced data spotlighting trends like pressure-to-turnover correlation and second-half scoring splits, this week’s slate is primed for volatility and betting opportunity. Whether it’s an over-performing underdog or a powerhouse primed for regression, our AI Week 6 NFL picks break down every matchup with precision — finding the edges that emotion and public bias tend to overlook.
That's pressure 😮💨🔒@jalendye1 x @treylathan5 pic.twitter.com/FYUCvUQ6IN
— Kansas Football (@KU_Football) October 6, 2025
Live AI NFL Picks — Week 6
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL schedule.
Below is our current AI NFL picks Week 6, NFL computer picks Week 6, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NFL | 10/6 | KC@JAC | UNLOCK THIS PICK | 6 |
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| NFL | 10/6 | KC@JAC | UNLOCK THIS PICK | 3 |
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| NFL | 10/6 | KC@JAC | UNLOCK THIS PICK | 0 |
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| NFL | 10/6 | KC@JAC | UNLOCK THIS PICK | 1 |
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Week 6 Storylines & Angles
Offense vs. Defense Mismatches
Week 6 of the 2025 NFL season features some of the most fascinating offensive and defensive mismatches of the year, with EPA/play and success rate trends exposing where the biggest betting edges lie. The San Francisco 49ers remain the gold standard in offensive efficiency, leading the league with +0.28 EPA/play behind Brock Purdy’s near-flawless execution and a run game averaging 5.2 yards per carry, but they’ll face a Dallas defense that ranks first in success rate allowed (34%) and has generated pressure on 39% of dropbacks. Meanwhile, the Kansas City Chiefs continue to thrive in red-zone precision, converting touchdowns on 73% of their trips inside the 20, while the Baltimore Ravens counter with a bend-but-don’t-break defense allowing a touchdown on just 45% of opponents’ red-zone possessions. Miami’s offense, fueled by Tua Tagovailoa’s quick-strike accuracy, leads the NFL in explosive plays (38 of 20+ yards), but they’ll be tested by a Bills defense ranked top-three in limiting those chunk gains — a matchup that could hinge on pass protection against Buffalo’s 11% sack rate. Protection metrics and tempo trends also define several Week 6 matchups where style and structure collide. The Philadelphia Eagles’ offensive line remains dominant, allowing pressure on only 12% of Jalen Hurts’ dropbacks, while the New York Jets’ front, anchored by Quinnen Williams, ranks top-five in pressure rate and run-stop win rate. Expect the Chargers and Bengals to push pace — both rank top-eight in plays per minute and top-ten in explosive-pass rate — making that matchup a potential shootout if protection holds. Conversely, teams like the Steelers and Giants remain mired in slow tempo and poor efficiency, ranking bottom-five in success rate and red-zone TD percentage. With EPA trends tightening across the league, Week 6 highlights the critical importance of trench play and finishing drives — the difference between teams that generate yards and those that turn them into points. Our AI projections spotlight these exact mismatches, identifying where protection breakdowns, pass-rush dominance, and pace differentials could determine both game outcomes and betting value.
Quarterback & Scheme Trends
Quarterback play and schematic adaptability headline the analytical storylines entering NFL Week 6, as efficiency under pressure and motion usage continue to separate elite offenses from the rest. Patrick Mahomes remains the league’s model of composure against the blitz, producing +0.35 EPA per play when pressured — thanks in large part to Andy Reid’s heavy reliance on pre-snap motion (used on 64% of plays) to diagnose defenses and create mismatches. Tua Tagovailoa’s rhythm passing remains unmatched, with Miami leading the NFL in motion-at-snap rate (71%) and explosive-pass percentage (17%), but he’ll face a Buffalo defense that disguises coverage more than any team in the league. On the opposite end, Justin Fields and Daniel Jones continue to struggle against pressure — both ranking bottom-five in completion rate when blitzed — exposing protection issues that have led to stalled drives and elevated turnover risk. Dak Prescott, meanwhile, is thriving under new play-caller Brian Schottenheimer’s balanced scheme, posting a league-best 78% success rate on throws from under center and benefiting from more play-action and condensed formations to neutralize pressure. Across the league, situational play-calling trends are beginning to reveal which coaching staffs are maximizing quarterback strengths and which are still searching for answers. The Detroit Lions have leaned heavily on under-center formations (53%) to fuel their efficient ground game and Jared Goff’s play-action success, while San Francisco’s Kyle Shanahan continues to lead the league in motion rate and first-down EPA/play thanks to his seamless sequencing between run looks and intermediate passing. In contrast, teams like the Jets and Patriots have struggled in high-leverage situations, with both ranking in the bottom quartile in red-zone efficiency and third-down conversion rate. Our AI models show that quarterbacks operating from motion-heavy systems are averaging 0.18 EPA/play more than those in static formations — a gap that widens significantly under pressure. As Week 6 unfolds, the teams capable of blending pre-snap movement, controlled tempo, and adaptable play-calling will dictate the game flow, while those failing to evolve schematically could once again find themselves on the wrong side of efficiency — and the spread.
Travel, Rest & Situational Spots
Week 6 of the 2025 NFL season presents one of the most complex slates of travel, rest, and situational challenges so far, with several teams facing scheduling disadvantages that could quietly influence outcomes. The Seattle Seahawks draw a brutal spot, flying cross-country for an early Sunday kickoff against the New York Jets — a classic “body-clock” game where West Coast teams historically see offensive efficiency drop by nearly 15%. Meanwhile, the Los Angeles Rams face the thin air of Denver after playing a Monday night road game, putting them in a short-week and altitude combination that often leads to fatigue in the second half. The Miami Dolphins, fresh off an emotional divisional win, could be staring at a classic let-down spot as they travel north to face a desperate Titans team in Nashville, while the 49ers’ trip to Arizona carries similar trap potential as San Francisco looks ahead to a prime-time showdown with the Chiefs in Week 7. From an analytics perspective, teams with short rest and cross-country travel have averaged -0.13 EPA/play in these situations over the past three seasons — numbers that bettors can’t afford to ignore when evaluating totals or spreads. The conference and rivalry dynamics add yet another layer of volatility to Week 6. The AFC North once again takes center stage as the Ravens and Steelers clash in a physical rematch that routinely features one-possession margins and totals that trend under historical averages due to defensive intensity and short rest between division opponents. Dallas and Philadelphia headline the NFC East schedule in what amounts to an early-season measuring stick, while the Chargers and Raiders meet in a game with both travel fatigue and emotional volatility — especially with Vegas returning home after consecutive road losses. Even subtle look-ahead spots loom large: Kansas City could be caught pacing itself against Minnesota before a massive matchup with Baltimore, and Detroit’s trip to Tampa Bay has sneaky “trap” potential following consecutive wins. These situational nuances — body-clock fatigue, travel mileage, and psychological swings — are precisely the hidden variables our AI models account for, identifying where sharp bettors can find inefficiencies the market tends to overlook.
Weather & Late-Breaking Injuries
Weather is set to play a meaningful role in shaping several NFL Week 6 matchups, with wind and rain posing legitimate threats to passing efficiency and scoring totals. Historically, sustained winds above 15 mph reduce completion rates on deep throws by roughly 18%, and several outdoor games are trending toward that threshold — including the Bills–Dolphins divisional clash in Buffalo and the Bears–Lions matchup at Soldier Field. Forecasts in Cleveland and Pittsburgh also point to steady rain, which could shift game scripts toward run-heavy approaches, further favoring defenses already ranking top-10 in rush EPA. Cold temperatures and crosswinds in Denver could affect both kick accuracy and ball trajectory, a factor bettors should weigh carefully in totals markets. When weather limits vertical passing, offenses with efficient short-game structure — like San Francisco’s quick-strike attack or Kansas City’s motion-based scheme — historically maintain production, while teams reliant on deep play-action, such as Miami or Seattle, see a notable dip in explosive play rate. Player health also adds another layer of volatility to the Week 6 slate, as several high-impact stars are trending toward questionable designations. Lamar Jackson (ankle) and Joe Burrow (hand) are both expected to play but could see reduced designed runs or altered game plans emphasizing short passes. The 49ers may limit Christian McCaffrey’s touches after a heavy workload in Week 5, while Detroit’s Amon-Ra St. Brown (knee) and Philadelphia’s A.J. Brown (hamstring) are both listed as game-time decisions, potentially shifting target shares to secondary receivers. On defense, the Cowboys could again be without Micah Parsons (shoulder), significantly affecting their pass-rush win rate, while the Jets may rotate Sauce Gardner’s snaps due to a minor groin issue. These injury and usage variables, when combined with volatile weather conditions, could suppress overall offensive efficiency leaguewide — making Week 6 one of the most unpredictable slates of the season for totals bettors and fantasy managers alike.
Check up to the minute weather forecasts here.
Credit: USA TODAY/IMAGN
NFL Week 6 Best Bets & AI Prop Picks
Week 6 NFL Best Bet – Pro Tips
Note Price sensitivity: We crunch numbers, not teams. If the market moves beyond our
buy-to number, expected value decays and the edge can disappear. Respect the price.
Unit sizing (1–10): Our unit scale reflects model signal strength, injury/variance risk,
and current line availability. Higher units = stronger conviction, not permission to over-expose.
Staking & correlation: Default stake scales with edge and volatility. Avoid stacking too many
correlated outcomes (same game, same player ladder) unless you deliberately size down.
Closing-Line Value (CLV): Beating the close consistently is a quality signal—even across small samples.
Track your entry vs. close; it’s the most reliable feedback loop for long-term profitability.
Week 6 Line Movement
Every pick includes a playable to line or price (e.g., -2.5, Over 44.5, +115). If you can’t get that number or better, consider passing or reducing stake. Lines move—check back for live updates in our Live AI Picks stream and see quick notes in Odds & Line Movement.
Note – all of our data is for informational purposes only and not a recommendation as to whether or how to wager.
and we're back‼️#EmbraceTheGrind | #AKC pic.twitter.com/Je5fpJapcr
— Jax State Football (@JaxStateFB) October 6, 2025
Line Movement Tracker — Week 6
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Oct 9, 2025 8:15PM EDT
Philadelphia Eagles
New York Giants
10/9/25 8:15PM
Eagles
Giants
|
–
–
|
-385
+306
|
-7 (-112)
+7 (+101)
|
O 41 (-107)
U 41 (-107)
|
|
|
Oct 12, 2025 8:31AM EDT
Denver Broncos
New York Jets
10/12/25 8:31AM
Broncos
Jets
|
–
–
|
-400
+316
|
-7 (-113)
+7 (+102)
|
O 43.5 (-110)
U 43.5 (-104)
|
|
|
Oct 12, 2025 1:00PM EDT
Seattle Seahawks
Jacksonville Jaguars
10/12/25 1PM
Seahawks
Jaguars
|
–
–
|
-107
-120
|
+1 (-114)
-1 (-112)
|
O 46 (-112)
U 46 (-114)
|
|
|
Oct 12, 2025 1:01PM EDT
Cleveland Browns
Pittsburgh Steelers
10/12/25 1:01PM
Browns
Steelers
|
–
–
|
+201
-242
|
+5 (-103)
-5 (-107)
|
O 38 (-113)
U 38 (-102)
|
|
|
Oct 12, 2025 1:01PM EDT
Los Angeles Chargers
Miami Dolphins
10/12/25 1:01PM
Chargers
Dolphins
|
–
–
|
-215
+183
|
-4 (-106)
+4 (-104)
|
O 43 (-107)
U 43 (-107)
|
|
|
Oct 12, 2025 1:01PM EDT
Los Angeles Rams
Baltimore Ravens
10/12/25 1:01PM
Rams
Ravens
|
–
–
|
-435
+310
|
-7.5 (-114)
+7.5 (-112)
|
O 45.5 (-112)
U 45.5 (-113)
|
|
|
Oct 12, 2025 1:01PM EDT
Dallas Cowboys
Carolina Panthers
10/12/25 1:01PM
Cowboys
Panthers
|
–
–
|
-182
+159
|
-3.5 (+105)
+3.5 (-116)
|
O 49.5 (-107)
U 49.5 (-107)
|
|
|
Oct 12, 2025 1:01PM EDT
Arizona Cardinals
Indianapolis Colts
10/12/25 1:01PM
Cardinals
Colts
|
–
–
|
+245
-300
|
+6.5 (-105)
-6.5 (-105)
|
O 47.5 (-107)
U 47.5 (-107)
|
|
|
Oct 12, 2025 4:06PM EDT
Tennessee Titans
Las Vegas Raiders
10/12/25 4:06PM
Titans
Raiders
|
–
–
|
+189
-225
|
+4.5 (-107)
-4.5 (-103)
|
O 41.5 (-104)
U 41.5 (-110)
|
|
|
Oct 12, 2025 4:25PM EDT
New England Patriots
New Orleans Saints
10/12/25 4:25PM
Patriots
Saints
|
–
–
|
-200
+174
|
-3.5 (-110)
+3.5 (+100)
|
O 46 (-107)
U 46 (-107)
|
|
|
Oct 12, 2025 4:26PM EDT
Cincinnati Bengals
Green Bay Packers
10/12/25 4:26PM
Bengals
Packers
|
–
–
|
+754
-1200
|
+15.5 (-118)
-15.5 (+107)
|
O 44.5 (-107)
U 44.5 (-107)
|
|
|
Oct 12, 2025 4:26PM EDT
San Francisco 49ers
Tampa Bay Buccaneers
10/12/25 4:26PM
49ers
Buccaneers
|
–
–
|
+130
-150
|
+3 (-112)
-3 (+101)
|
O 47.5 (-107)
U 47.5 (-107)
|
|
|
Oct 12, 2025 8:20PM EDT
Detroit Lions
Kansas City Chiefs
10/12/25 8:20PM
Lions
Chiefs
|
–
–
|
-106
-121
|
+1 (-113)
-1 (-113)
|
O 50 (-110)
U 50 (-115)
|
|
|
Oct 13, 2025 7:15PM EDT
Buffalo Bills
Atlanta Falcons
10/13/25 7:15PM
Bills
Falcons
|
–
–
|
-195
+170
|
-3.5 (-105)
+3.5 (-105)
|
O 48.5 (-102)
U 48.5 (-113)
|
|
|
Oct 13, 2025 8:16PM EDT
Chicago Bears
Washington Commanders
10/13/25 8:16PM
Bears
Commanders
|
–
–
|
+189
-225
|
+4.5 (-107)
-4.5 (-103)
|
O 50 (-113)
U 50 (-102)
|
How Our AI Picks Work
Our NFL model blends play-by-play efficiency, drive-level simulations, and market-aware priors. We incorporate injury reports, rest/travel effects, and weather to adjust team strength and total expectations. Each game is simulated thousands of times to produce fair prices; the displayed Model Edge % is the gap between our fair price and the current market.
Market-aware: incorporates liquidity windows and closing-line efficiency.
Context-adjusted: rest days, travel, altitude, tempo, and scheme tendencies.
Transparency: we show confidence, edges, and track CLV and ROI.
Remi, our AI sports algorithm, has been pouring over millions of data from every simulation across NFL week 6 using recursive machine learning to industry leading AI to crunch the data to a single cover probability.
The Algorithm has been most keyed in on the growing factor human bettors regularly put on coaching factors between a visitors team going up against a possibly deflated home teams. It appears the true game analytics might reflect a strong lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
FAQ — Week 6 NFL
Where can I see Week 6 NFL AI picks by bet type?
Right on this page. We publish Week 6 NFL computer picks organized by Against the Spread (ATS), Moneyline, Totals (Over/Under), and Player Props so you can jump straight to the markets you bet most.
What are the “best bets” for Week 6 according to the model?
“Best bets” are our highest-confidence Week 6 NFL AI picks based on fair price vs. current odds. Look for larger Model Edge % and higher confidence stars; those signal stronger value at widely available prices.
How are your Week 6 NFL computer picks generated?
We combine play-by-play data, drive-level simulations, and market-aware priors. The model produces a fair price for each side/total/prop, then compares it to live odds to surface Week 6 edges worth betting.
How often do you update Week 6 NFL AI picks?
Throughout the week and up to kickoff. As injuries, weather, and prices move, our projections refresh—so check back closer to game time for the most accurate read on Week 6 value.
Do your Week 6 picks include player props like anytime TD or yardage?
Yes. Our Week 6 NFL AI picks include props such as anytime touchdown, rushing/receiving yards, passing yards, attempts, and more when markets are liquid and pricing shows an edge.
Do you post same-game parlay (SGP) ideas for Week 6?
When correlations and prices justify it, we highlight SGP concepts tied to our Week 6 AI edges—think side/total anchored to complementary player props. We only list combos when expected value remains positive.
What do Model Edge % and units mean?
Model Edge % is the gap between our fair price and the current line/price. Units (1–10) summarize signal quality, volatility, and line availability for Week 6 NFL AI picks.
What are “buy-to” numbers, and what if the line moves?
“Buy-to” is the furthest playable number before expected value disappears. If the market pushes past that level, the Week 6 pick may no longer qualify—wait for a better price or skip the bet.
Do you track closing-line value (CLV) and ROI for Week 6?
Yes. We grade results against widely available prices at publish time and monitor CLV to gauge process quality. You’ll also find recent record and ROI to keep Week 6 performance transparent.
How should I size bets on Week 6 NFL AI picks?
Scale stake size with edge and volatility. Larger Model Edge % and higher confidence typically merit slightly larger positions, but avoid over-exposure to correlated outcomes within the same game.
Are teasers viable for Week 6?
Sometimes. Teasers can make sense around key numbers when totals and pricing conditions are favorable. If our Week 6 read flags teaser value, we’ll note the recommended legs and limits.
How do injuries, weather, and travel impact Week 6 NFL picks?
Materially. The model adjusts team strength, pace, and totals for late scratches, snap-count news, wind/rain/cold thresholds, altitude, rest, and travel. Those inputs can change edges close to kickoff.
Where can I compare Week 6 NFL odds to shop the best number?
Use your preferred odds screen or our odds links from this page. Shopping lines is essential—Model Edge % is calculated against available prices, and the best number often determines long-term ROI.
Can I get alerts when new Week 6 NFL AI picks post or when lines move to buy-to?
Yes. Enable notifications or subscribe for alerts so you catch new Week 6 AI picks, notable line moves, and updates to buy-to ranges before the market fully adjusts.
Past NFL AI Picks
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
| DET@CIN | DET -10 | 55.6% | 5 | WIN |
| DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
| TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
| TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
| DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
| MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
| LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
| SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
| NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
| CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
| NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
| CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
| NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
| CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
| WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
| BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
| TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
| LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
| NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
| GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
| CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |
| GB@CLE | GB -7 | 54.3% | 4 | LOSS |
| ARI@SF | ARI +3 | 57.7% | 6 | WIN |
| KC@NYG | PATRICK MAHOMES OVER 230.5 PASS YDS | 54.7% | 4 | WIN |
| GB@CLE | JOE FLACCO OVER 37.5 PASS ATT | 56.6% | 6 | LOSS |
| MIA@BUF | TYREEK HILL OVER 5.5 TOTAL RECEPTIONS | 56.8% | 6 | LOSS |
| LAC@LV | LAC -3 | 54.9% | 4 | WIN |
| TB@HOU | BAKER MAYFIELD OVER 1.5 PASS TDS | 54.4% | 4 | WIN |
| CHI@DET | DET -6.5 | 54.3% | 4 | WIN |
| DEN@IND | DEN -118 | 60.1% | 10 | LOSS |
| PHI@KC | PHI -115 | 56.7% | 6 | WIN |
| SF@NO | SF -3 | 58.8% | 8 | WIN |
| SEA@PIT | OVER 40 | 54.9% | 4 | WIN |
| CAR@ARI | BRYCE YOUNG INTERCEPTIONS UNDER 0.5 | 56.4% | 6 | LOSS |
| DEN@IND | JOSH DOWNS RECEPTIONS OVER 3.5 | 54.7% | 4 | WIN |
| ATL@MIN | BIJAN ROBINSON RUSH + REC YDS OVER 94.5 | 53.4% | 3 | WIN |
| WAS@GB | WAS +3.5 | 56.5% | 6 | LOSS |
| WAS@GB | JORDAN LOVE OVER 5.5 RUSH YDS | 54.7% | 4 | WIN |
| MIN@CHI | CALEB WILLIAMS OVER 219.5 PASS YDS | 53.4% | 3 | LOSS |
| TEN@DEN | DEN -8.5 | 55.3% | 5 | LOSS |
| SF@SEA | SF -115 | 54.6% | 4 | WIN |
| SF@SEA | KENNETH WALKER III UNDER 79.5 RUSH+REC YDS | 54.6% | 4 | WIN |
| CAR@JAC | TANK BIGSBY OVER 10.5 RUSH ATT | 56.1% | 6 | LOSS |