Pelicans vs Grizzlies Prediction — AI Finds CAN'T MISS NBA Lines & Props (Oct 22)

Updated: 2025-10-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The New Orleans Pelicans travel to face the Memphis Grizzlies on October 22, 2025, in what could be a high-octane contest fueled by transition opportunities and interior matchups. New Orleans is expected to struggle with consistency on defense, while Memphis will try to assert control through paint dominance and tempo.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Oct 22, 2025

Start Time: 8:00 PM​

Venue: FedExForum​

Grizzlies Record: (0-0)

Pelicans Record: (0-0)

OPENING ODDS

NO Moneyline: +137

MEM Moneyline: -163

NO Spread: +3.5

MEM Spread: -3.5

Over/Under: 234.5

NO
Betting Trends

  • The Pelicans have a recent track record of 46–41–1 against the spread.

MEM
Betting Trends

  • The Grizzlies posted a 40–42 ATS mark in their recent campaigns.

MATCHUP TRENDS

  • When Memphis is favored at home, lines often assume they’ll dominate inside, making over-reliance on the paint sometimes aggressive. New Orleans has occasionally covered on the road when they force uptempo games and make Memphis uncomfortable in transition. Grizzlies’ home ATS is stronger than their overall splits, giving them a built-in edge in familiar settings.

NO vs. MEM
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup:

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New Orleans vs Memphis Prediction & Odds:
Free NBA Betting Insights for 10/22/25

The October 22, 2025 matchup between the New Orleans Pelicans and the Memphis Grizzlies at FedExForum brings together two teams defined by physicality, athleticism, and evolving identities as they look to establish early momentum in the new NBA season. For the Pelicans, this game represents a critical opportunity to prove that their core—anchored by Zion Williamson, Brandon Ingram, and CJ McCollum—can stay healthy and translate its offensive potential into consistency against a rugged Grizzlies defense. New Orleans will look to dictate pace through quick transition pushes and spacing that opens lanes for Zion’s explosive drives and Ingram’s smooth midrange game. The Pelicans’ success hinges on ball movement and outside shooting; when they share the rock and knock down perimeter looks, their offense becomes nearly unguardable. Trey Murphy III and Herb Jones will be pivotal in spreading the floor and defending Memphis’s wings, while Jonas Valančiūnas will have to assert himself inside against Jaren Jackson Jr. and Memphis’s athletic frontcourt. For Memphis, the key lies in leveraging home-court energy and their defensive backbone to disrupt the Pelicans’ rhythm. Ja Morant’s speed and vertical burst make him a constant threat in transition, while Desmond Bane’s shooting and playmaking continue to evolve into elite territory.

The Grizzlies’ success under head coach Taylor Jenkins has been rooted in defensive discipline, aggressive rebounding, and unselfish play, and that will again be their formula against a New Orleans team that thrives in chaos. With Jackson Jr. manning the paint and Marcus Smart providing leadership and toughness on the perimeter, Memphis will look to slow the Pelicans’ scoring surges by switching intelligently and collapsing on drives without overcommitting. The matchup between Morant and McCollum should be electric, as both guards excel at creating off the dribble and controlling tempo, while Ingram’s matchup against Bane or Smart could decide how efficiently New Orleans can generate offense in the half-court. Bench contributions will play an enormous role—players like Luke Kennard and Santi Aldama for Memphis, and Jose Alvarado and Larry Nance Jr. for New Orleans, bring defensive intensity and secondary scoring that can swing the game’s momentum. Rebounding, second-chance points, and turnovers will likely determine the outcome, as both teams rank among the league’s best in forcing mistakes but can also be streaky offensively. The Grizzlies’ home environment provides a substantial edge, especially with their ability to feed off crowd energy during defensive runs, while the Pelicans’ challenge will be staying composed and organized under pressure. Expect a gritty, back-and-forth contest marked by physical battles in the paint, explosive fast breaks, and spurts of brilliance from the stars on both sides. In the end, the team that controls tempo and avoids foul trouble will have the upper hand, but this matchup promises playoff-level intensity from two Western Conference teams eager to define their direction in 2025.

New Orleans Pelicans NBA Preview

The New Orleans Pelicans enter their October 22, 2025 matchup against the Memphis Grizzlies with something to prove as they continue to solidify their identity as a balanced, dynamic team capable of challenging the Western Conference elite. Under head coach Willie Green, the Pelicans have worked to combine their explosive offensive potential with greater defensive discipline and composure on the road, a task that becomes particularly vital against a physical Grizzlies team that thrives on tempo control and paint dominance. Offensively, New Orleans will rely heavily on Zion Williamson’s ability to attack downhill and draw multiple defenders, creating opportunities for Brandon Ingram and CJ McCollum to exploit defensive gaps and punish overhelping with midrange jumpers or three-point shots. The Pelicans have often looked their best when playing unselfishly—quick ball movement, spacing, and patience in half-court sets open lanes and rhythm threes that make them difficult to contain. Trey Murphy III’s continued growth as a perimeter scorer and defender provides a vital two-way lift, while Herb Jones’s defensive versatility will be crucial in slowing down Memphis’s explosive backcourt led by Ja Morant and Desmond Bane. For New Orleans to compete on the road, rebounding and transition defense will be non-negotiable.

Jonas Valančiūnas faces a key test against Jaren Jackson Jr. and the Grizzlies’ active bigs, and his ability to hold his ground on the glass will dictate whether the Pelicans can limit Memphis’s second-chance points. On defense, communication and discipline are essential; Memphis will look to run the floor off turnovers, so the Pelicans’ backcourt must stay alert to cut off outlets and contest early offense. Off the bench, Jose Alvarado’s energy, Larry Nance Jr.’s hustle, and rookie contributions from players like Jordan Hawkins could provide the spark New Orleans needs to keep pace. The Pelicans’ challenge has often been sustaining effort for four quarters, especially in hostile environments, but this game offers an ideal opportunity to demonstrate growth. If New Orleans can manage turnovers, stay aggressive from beyond the arc, and contain Morant’s penetration without fouling, they have the tools to steal a tough road victory. More importantly, this game serves as a measuring stick for how far their young core has come in terms of chemistry, poise, and execution. The Pelicans’ ceiling remains tied to their ability to adapt midgame—balancing half-court patience with their natural athletic instincts—and to withstand the physical grind of Memphis’s defense. For Zion and Ingram, it’s another chance to show they can lead not just with talent but with control and decision-making. A win in Memphis would mark a statement victory for New Orleans, signaling that the Pelicans are ready to translate promise into consistency, even against one of the toughest home environments in the league.

The New Orleans Pelicans travel to face the Memphis Grizzlies on October 22, 2025, in what could be a high-octane contest fueled by transition opportunities and interior matchups. New Orleans is expected to struggle with consistency on defense, while Memphis will try to assert control through paint dominance and tempo. New Orleans vs Memphis AI Prediction: Free NBA Betting Insights for Oct 22. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Memphis Grizzlies NBA Preview

The Memphis Grizzlies enter their October 22, 2025 home matchup against the New Orleans Pelicans with confidence, looking to impose their physical identity and reassert themselves as one of the most disciplined and cohesive units in the Western Conference. Playing at FedExForum, Memphis will look to feed off the energy of one of the league’s most passionate home crowds, where their fast-paced, defensive-minded brand of basketball thrives. The Grizzlies’ formula remains built around controlling tempo, dominating the boards, and suffocating opponents with pressure defense that limits easy points in transition. Ja Morant remains the spark plug, and his ability to blend speed, creativity, and scoring will be central to breaking down the Pelicans’ defense. When Morant attacks downhill, Memphis’s spacing and motion offense become lethal—Desmond Bane’s perimeter shooting and playmaking keep defenders honest, while Jaren Jackson Jr.’s ability to stretch the floor and protect the rim adds balance at both ends. Jackson’s matchup with Jonas Valančiūnas will be pivotal, as his ability to defend without fouling and to convert second-chance opportunities could dictate the Grizzlies’ rhythm early. On the defensive end, Marcus Smart’s leadership and on-ball intensity give Memphis a strategic advantage, particularly in containing CJ McCollum and disrupting the Pelicans’ backcourt flow.

The Grizzlies will focus on forcing New Orleans into tough midrange looks, cutting off passing lanes to Zion Williamson, and collapsing the paint when he drives. Memphis’s depth, one of its most consistent strengths, will again play a major role—Luke Kennard’s shooting, Santi Aldama’s versatility, and Derrick Rose’s veteran savvy provide stability and scoring when the starters rest. Offensively, the Grizzlies will aim to push the pace after defensive stops, hunting early transition opportunities before New Orleans can set its defense. When slowed into half-court play, Memphis will rely on movement and patience to exploit mismatches and open perimeter looks. They’ll need to stay disciplined, as overhelping against the Pelicans’ drive-heavy attack can open kick-out opportunities that swing momentum quickly. Expect Memphis to emphasize rebounding as well; securing the glass and limiting the Pelicans to one shot per possession will be critical to maintaining control. If the Grizzlies’ defense remains locked in and their secondary scorers find rhythm early, Memphis can build separation and dictate the pace. This game also serves as a measuring stick for their continued evolution—how well they blend their trademark toughness with improved offensive efficiency and composure in crunch time. With Morant’s explosiveness, Bane’s consistency, and Jackson’s interior presence, the Grizzlies have the tools to make life difficult for New Orleans and protect their home floor. If they execute their defensive schemes, capitalize on turnovers, and keep their offensive spacing fluid, Memphis will be well-positioned to open their season with an emphatic statement win that reaffirms their place among the conference’s most complete teams.

New Orleans vs. Memphis Prop Picks (AI)

Remi is pouring through tons of stats on each line. In fact, anytime the Pelicans and Grizzlies play there’s always several intriguing observations to key in on. Not to mention games played at FedExForum in Oct seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup:

New Orleans vs. Memphis Prediction (AI)

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Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every facet between the Pelicans and Grizzlies and using recursive machine learning and industry leading AI to examine the data to a single cover probability.

Interestingly enough, the data has been most focused on the growing factor human bettors tend to put on Memphis’s strength factors between a Pelicans team going up against a possibly rested Grizzlies team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NBA AI picks for FREE now.

Below is our current AI New Orleans vs Memphis picks, computer picks Pelicans vs Grizzlies, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NBA schedule.

Pelicans Betting Trends

The Pelicans have a recent track record of 46–41–1 against the spread.

Grizzlies Betting Trends

The Grizzlies posted a 40–42 ATS mark in their recent campaigns.

Pelicans vs. Grizzlies Matchup Trends

When Memphis is favored at home, lines often assume they’ll dominate inside, making over-reliance on the paint sometimes aggressive. New Orleans has occasionally covered on the road when they force uptempo games and make Memphis uncomfortable in transition. Grizzlies’ home ATS is stronger than their overall splits, giving them a built-in edge in familiar settings.

New Orleans vs. Memphis Game Info

New Orleans vs Memphis starts on October 22, 2025 at 8:00 PM.

Spread: Memphis -3.5
Moneyline: New Orleans +137, Memphis -163
Over/Under: 234.5

New Orleans: (0-0)  |  Memphis: (0-0)

Remi's searched hard and found the best prop for this matchup:. Prices move—always shop for the best number.

When Memphis is favored at home, lines often assume they’ll dominate inside, making over-reliance on the paint sometimes aggressive. New Orleans has occasionally covered on the road when they force uptempo games and make Memphis uncomfortable in transition. Grizzlies’ home ATS is stronger than their overall splits, giving them a built-in edge in familiar settings.

NO trend: The Pelicans have a recent track record of 46–41–1 against the spread.

MEM trend: The Grizzlies posted a 40–42 ATS mark in their recent campaigns.

See our latest NBA picks and odds pages for 2025 to compare prices before you bet.

New Orleans vs. Memphis Odds

Remi is pouring through loads of stats on each line. In fact, anytime the New Orleans vs Memphis trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable patterns.

New Orleans vs Memphis Opening Odds

NO Moneyline: +137
MEM Moneyline: -163
NO Spread: +3.5
MEM Spread: -3.5
Over/Under: 234.5

New Orleans vs Memphis Live Odds

Games PTS ML SPR O/U
Oct 21, 2025 7:35PM EDT
Houston Rockets
Oklahoma City Thunder
10/21/25 7:35PM
Rockets
Thunder
+240
-300
+7.5 (-106)
-7.5 (-106)
O 227 (-107)
U 227 (-107)
Oct 21, 2025 10:00PM EDT
Golden State Warriors
Los Angeles Lakers
10/21/25 10PM
Warriors
Lakers
-125
+105
-1.5 (-111)
+1.5 (-101)
O 223 (-107)
U 223 (-107)
Oct 22, 2025 7:10PM EDT
Brooklyn Nets
Charlotte Hornets
10/22/25 7:10PM
Nets
Hornets
+150
-185
+4.5 (-110)
-4.5 (-110)
O 223.5 (-110)
U 223.5 (-110)
Oct 22, 2025 7:10PM EDT
Cleveland Cavaliers
New York Knicks
10/22/25 7:10PM
Cavaliers
Knicks
+145
-175
+4.5 (-115)
-4.5 (-105)
O 229.5 (-110)
U 229.5 (-110)
Oct 22, 2025 7:10PM EDT
Miami Heat
Orlando Magic
10/22/25 7:10PM
Heat
Magic
+310
-400
+8.5 (-115)
-8.5 (-105)
O 214.5 (-110)
U 214.5 (-110)
Oct 22, 2025 7:40PM EDT
Philadelphia 76ers
Boston Celtics
10/22/25 7:40PM
76ers
Celtics
+120
-145
+2.5 (-105)
-2.5 (-115)
O 224.5 (-110)
U 224.5 (-110)
Oct 22, 2025 7:40PM EDT
Toronto Raptors
Atlanta Hawks
10/22/25 7:40PM
Raptors
Hawks
+200
-250
+6.5 (-115)
-6.5 (-105)
O 235.5 (-110)
U 235.5 (-110)
Oct 22, 2025 8:10PM EDT
Washington Wizards
Milwaukee Bucks
10/22/25 8:10PM
Wizards
Bucks
+310
-400
+8.5 (-105)
-8.5 (-115)
O 227.5 (-115)
U 227.5 (-105)
Oct 22, 2025 8:10PM EDT
Detroit Pistons
Chicago Bulls
10/22/25 8:10PM
Pistons
Bulls
-145
+120
-2.5 (-110)
+2.5 (-110)
O 234.5 (-110)
U 234.5 (-110)
Oct 22, 2025 8:10PM EDT
New Orleans Pelicans
Memphis Grizzlies
10/22/25 8:10PM
Pelicans
Grizzlies
+135
-160
+3.5 (-110)
-3.5 (-110)
O 234.5 (-110)
U 234.5 (-110)
Oct 22, 2025 9:10PM EDT
Los Angeles Clippers
Utah Jazz
10/22/25 9:10PM
Clippers
Jazz
-375
+300
-8.5 (-110)
+8.5 (-110)
O 227.5 (-115)
U 227.5 (-105)
Oct 22, 2025 9:40PM EDT
San Antonio Spurs
Dallas Mavericks
10/22/25 9:40PM
Spurs
Mavericks
+115
-135
+2.5 (-110)
-2.5 (-110)
O 225.5 (-110)
U 225.5 (-110)
Oct 22, 2025 10:10PM EDT
Sacramento Kings
Phoenix Suns
10/22/25 10:10PM
Kings
Suns
-110
-110
-1.5 (+100)
+1.5 (-120)
O 227.5 (-110)
U 227.5 (-110)
Oct 22, 2025 10:10PM EDT
Minnesota Timberwolves
Portland Trail Blazers
10/22/25 10:10PM
Timberwolves
Trail Blazers
-150
+125
-2.5 (-115)
+2.5 (-105)
O 219.5 (-110)
U 219.5 (-110)
Oct 23, 2025 7:40PM EDT
Oklahoma City Thunder
Indiana Pacers
10/23/25 7:40PM
Thunder
Pacers
-350
+260
-7.5 (-110)
+7.5 (-110)
O 226 (-110)
U 226 (-110)
Oct 23, 2025 10:10PM EDT
Denver Nuggets
Golden State Warriors
10/23/25 10:10PM
Nuggets
Warriors
-110
-110
+1 (-115)
-1 (-105)
O 233.5 (-110)
U 233.5 (-110)

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We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers New Orleans Pelicans vs. Memphis Grizzlies on October 22, 2025 at FedExForum.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NBA odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
IND@OKC PASCAL SIAKAM OVER 2.5 PERSONAL FOULS 54.20% 4 WIN
IND@OKC IND +10 54.00% 3 WIN
IND@OKC BENNEDICT MATHURIN OVER 2.5 FREE THROW ATT 54.90% 4 WIN
NY@IND MYLES TURNER OVER 6 REBOUNDS + ASSTS 54.40% 4 LOSS
IND@NY IND +5 55.60% 5 LOSS
NY@IND JALEN BRUNSON UNDER 22 FIELD GOAL ATT 54.70% 4 WIN
OKC@MIN RUDY GOBERT OVER 1.5 FREE THROWS MADE 54.00% 4 WIN
OKC@MIN OKC -2.5 56.70% 6 LOSS
NY@IND KARL ANTHONY TOWNS OVER 32.5 POINTS + REBOUNDS 54.00% 4 WIN
OKC@MIN NAZ REID OVER 9.0 FIELD GOAL ATT 54.60% 4 LOSS
IND@NY MYLES TURNER OVER 5 MADE FIELD GOALS 53.60% 3 WIN
IND@NY NY -5.5 55.00% 4 LOSS
MIN@OKC ISAIAH HARTENSTEIN UNDER 7.5 REBOUNDS 53.00% 3 LOSS
MIN@OKC MIN +7.5 54.70% 4 LOSS
IND@NY TYRESE HALIBURTON ASSTS - UNDER 8.5 54.10% 4 LOSS
IND@NY IND +4.5 54.80% 4 WIN
MIN@OKC ALEX CARUSO UNDER 2.5 ASSTS 54.10% 4 WIN
DEN@OKC MICHAEL PORTER UNDER 7.5 REBS + AST 54.80% 4 WIN
BOS@NY NY -2.5 55.60% 5 WIN
GS@MIN DONTE DIVINCENZO OVER 1.5 TURNOVERS 54.80% 4 LOSS
GS@MIN GS +10.5 54.70% 4 LOSS
DEN@OKC NIKOLA JOKIC UNDER 22.5 REBOUNDS + ASSTS 54.00% 4 WIN
MIN@GS JIMMY BUTLER UNDER 33.5 POINTS + REBOUNDS 54.50% 4 WIN
BOS@NY BOS -5.5 54.70% 4 WIN
OKC@DEN OKC -5 55.70% 5 LOSS
DEN@OKC SHAI GILGEOUS-ALEXANDER UNDER 12.5 REBOUNDS + ASSTS 54.20% 4 WIN
IND@CLE IND +8 54.00% 3 WIN
GS@MIN ANTHONY EDWARDS UNDER 40.5 PTS+REB+AST 54.00% 4 WIN
GS@MIN MIN -6.5 54.40% 4 LOSS
DEN@OKC NIKOLA JOKIC UNDER 36.5 POINTS + ASSTS 53.20% 3 LOSS
IND@CLE IND +8.5 55.70% 5 WIN
HOU@GS GS -5 53.70% 3 LOSS
HOU@GS BRANDIN PODZIEMSKI UNDER 5.5 REBOUNDS 54.10% 4 LOSS
DEN@LAC MICHAEL PORTER UNDER 7.5 REBS + AST 53.20% 3 WIN
DEN@LAC UNDER 212.5 54.00% 3 LOSS
MIN@LAL MIN +6 53.80% 3 WIN
MIN@LAL NAZ REID OVER 1.5 ASSTS 54.80% 4 WIN
LAC@DEN IVICA ZUBAC OVER 1.5 TURNOVERS 53.50% 3 LOSS
DET@NY DET +5.5 53.90% 3 WIN
CLE@MIA EVAN MOBLEY UNDER 29.5 PTS+REB+AST 53.90% 3 WIN
BOS@ORL KRISTAPS PORZINGIS UNDER 8.5 REBOUNDS + ASSTS 53.10% 3 WIN
HOU@GS GS -3 53.70% 3 WIN
HOU@GS JALEN GREEN OVER 2.5 TURNOVERS 54.40% 4 LOSS
LAL@MIN LEBRON JAMES UNDER 31.5 POINTS + REBOUNDS 54.50% 4 LOSS
BOS@ORL BOS -3.5 54.70% 4 LOSS
DEN@LAC BOGDAN BOGDANOVIC OVER 2.5 THREE POINTERS ATTEMPTED 53.60% 3 LOSS
GS@HOU JALEN GREEN UNDER 3.5 FREE THROWS MADE 54.40% 4 LOSS
ORL@BOS ORL +10.5 54.70% 4 WIN
MEM@OKC ISAIAH HARTENSTEIN OVER 19.5 PTS + REB 53.80% 3 LOSS
MEM@OKC OKC -14.5 54.80% 4 WIN
LAC@DEN IVICA ZUBAC OVER 3.5 OFFENSIVE REBOUNDS 53.30% 3 LOSS