New Orleans vs Memphis Prediction — AI Finds CAN'T MISS NBA Lines & Props (Oct 22)
Updated: 2025-10-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The New Orleans Pelicans travel to face the Memphis Grizzlies on October 22, 2025, in what could be a high-octane contest fueled by transition opportunities and interior matchups. New Orleans is expected to struggle with consistency on defense, while Memphis will try to assert control through paint dominance and tempo.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Oct 22, 2025
Start Time: 8:00 PM
Venue: FedExForum
Grizzlies Record: (0-0)
Pelicans Record: (0-0)
OPENING ODDS
NO Moneyline: +137
MEM Moneyline: -163
NO Spread: +3.5
MEM Spread: -3.5
Over/Under: 234.5
NO
Betting Trends
- The Pelicans have a recent track record of 46–41–1 against the spread.
MEM
Betting Trends
- The Grizzlies posted a 40–42 ATS mark in their recent campaigns.
MATCHUP TRENDS
- When Memphis is favored at home, lines often assume they’ll dominate inside, making over-reliance on the paint sometimes aggressive. New Orleans has occasionally covered on the road when they force uptempo games and make Memphis uncomfortable in transition. Grizzlies’ home ATS is stronger than their overall splits, giving them a built-in edge in familiar settings.
NO vs. MEM
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Poole over 18.5 PTS+AST.
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New Orleans vs Memphis Prediction & Odds:
Free NBA Betting Insights for 10/22/25
The October 22, 2025 matchup between the New Orleans Pelicans and the Memphis Grizzlies at FedExForum brings together two teams defined by physicality, athleticism, and evolving identities as they look to establish early momentum in the new NBA season. For the Pelicans, this game represents a critical opportunity to prove that their core—anchored by Zion Williamson, Brandon Ingram, and CJ McCollum—can stay healthy and translate its offensive potential into consistency against a rugged Grizzlies defense. New Orleans will look to dictate pace through quick transition pushes and spacing that opens lanes for Zion’s explosive drives and Ingram’s smooth midrange game. The Pelicans’ success hinges on ball movement and outside shooting; when they share the rock and knock down perimeter looks, their offense becomes nearly unguardable. Trey Murphy III and Herb Jones will be pivotal in spreading the floor and defending Memphis’s wings, while Jonas Valančiūnas will have to assert himself inside against Jaren Jackson Jr. and Memphis’s athletic frontcourt. For Memphis, the key lies in leveraging home-court energy and their defensive backbone to disrupt the Pelicans’ rhythm. Ja Morant’s speed and vertical burst make him a constant threat in transition, while Desmond Bane’s shooting and playmaking continue to evolve into elite territory.
The Grizzlies’ success under head coach Taylor Jenkins has been rooted in defensive discipline, aggressive rebounding, and unselfish play, and that will again be their formula against a New Orleans team that thrives in chaos. With Jackson Jr. manning the paint and Marcus Smart providing leadership and toughness on the perimeter, Memphis will look to slow the Pelicans’ scoring surges by switching intelligently and collapsing on drives without overcommitting. The matchup between Morant and McCollum should be electric, as both guards excel at creating off the dribble and controlling tempo, while Ingram’s matchup against Bane or Smart could decide how efficiently New Orleans can generate offense in the half-court. Bench contributions will play an enormous role—players like Luke Kennard and Santi Aldama for Memphis, and Jose Alvarado and Larry Nance Jr. for New Orleans, bring defensive intensity and secondary scoring that can swing the game’s momentum. Rebounding, second-chance points, and turnovers will likely determine the outcome, as both teams rank among the league’s best in forcing mistakes but can also be streaky offensively. The Grizzlies’ home environment provides a substantial edge, especially with their ability to feed off crowd energy during defensive runs, while the Pelicans’ challenge will be staying composed and organized under pressure. Expect a gritty, back-and-forth contest marked by physical battles in the paint, explosive fast breaks, and spurts of brilliance from the stars on both sides. In the end, the team that controls tempo and avoids foul trouble will have the upper hand, but this matchup promises playoff-level intensity from two Western Conference teams eager to define their direction in 2025.
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Pelicans are back in action TONIGHT 😤
— New Orleans Pelicans (@PelicansNBA) October 14, 2025
📍Legacy Arena
🏀 vs Rockets
📺 GCSEN/Pelicans+ pic.twitter.com/YtbL9EtZJJ
New Orleans Pelicans NBA Preview
The New Orleans Pelicans enter their October 22, 2025 matchup against the Memphis Grizzlies with something to prove as they continue to solidify their identity as a balanced, dynamic team capable of challenging the Western Conference elite. Under head coach Willie Green, the Pelicans have worked to combine their explosive offensive potential with greater defensive discipline and composure on the road, a task that becomes particularly vital against a physical Grizzlies team that thrives on tempo control and paint dominance. Offensively, New Orleans will rely heavily on Zion Williamson’s ability to attack downhill and draw multiple defenders, creating opportunities for Brandon Ingram and CJ McCollum to exploit defensive gaps and punish overhelping with midrange jumpers or three-point shots. The Pelicans have often looked their best when playing unselfishly—quick ball movement, spacing, and patience in half-court sets open lanes and rhythm threes that make them difficult to contain. Trey Murphy III’s continued growth as a perimeter scorer and defender provides a vital two-way lift, while Herb Jones’s defensive versatility will be crucial in slowing down Memphis’s explosive backcourt led by Ja Morant and Desmond Bane. For New Orleans to compete on the road, rebounding and transition defense will be non-negotiable.
Jonas Valančiūnas faces a key test against Jaren Jackson Jr. and the Grizzlies’ active bigs, and his ability to hold his ground on the glass will dictate whether the Pelicans can limit Memphis’s second-chance points. On defense, communication and discipline are essential; Memphis will look to run the floor off turnovers, so the Pelicans’ backcourt must stay alert to cut off outlets and contest early offense. Off the bench, Jose Alvarado’s energy, Larry Nance Jr.’s hustle, and rookie contributions from players like Jordan Hawkins could provide the spark New Orleans needs to keep pace. The Pelicans’ challenge has often been sustaining effort for four quarters, especially in hostile environments, but this game offers an ideal opportunity to demonstrate growth. If New Orleans can manage turnovers, stay aggressive from beyond the arc, and contain Morant’s penetration without fouling, they have the tools to steal a tough road victory. More importantly, this game serves as a measuring stick for how far their young core has come in terms of chemistry, poise, and execution. The Pelicans’ ceiling remains tied to their ability to adapt midgame—balancing half-court patience with their natural athletic instincts—and to withstand the physical grind of Memphis’s defense. For Zion and Ingram, it’s another chance to show they can lead not just with talent but with control and decision-making. A win in Memphis would mark a statement victory for New Orleans, signaling that the Pelicans are ready to translate promise into consistency, even against one of the toughest home environments in the league.
Credit: USA TODAY/IMAGN
Memphis Grizzlies NBA Preview
The Memphis Grizzlies enter their October 22, 2025 home matchup against the New Orleans Pelicans with confidence, looking to impose their physical identity and reassert themselves as one of the most disciplined and cohesive units in the Western Conference. Playing at FedExForum, Memphis will look to feed off the energy of one of the league’s most passionate home crowds, where their fast-paced, defensive-minded brand of basketball thrives. The Grizzlies’ formula remains built around controlling tempo, dominating the boards, and suffocating opponents with pressure defense that limits easy points in transition. Ja Morant remains the spark plug, and his ability to blend speed, creativity, and scoring will be central to breaking down the Pelicans’ defense. When Morant attacks downhill, Memphis’s spacing and motion offense become lethal—Desmond Bane’s perimeter shooting and playmaking keep defenders honest, while Jaren Jackson Jr.’s ability to stretch the floor and protect the rim adds balance at both ends. Jackson’s matchup with Jonas Valančiūnas will be pivotal, as his ability to defend without fouling and to convert second-chance opportunities could dictate the Grizzlies’ rhythm early. On the defensive end, Marcus Smart’s leadership and on-ball intensity give Memphis a strategic advantage, particularly in containing CJ McCollum and disrupting the Pelicans’ backcourt flow.
The Grizzlies will focus on forcing New Orleans into tough midrange looks, cutting off passing lanes to Zion Williamson, and collapsing the paint when he drives. Memphis’s depth, one of its most consistent strengths, will again play a major role—Luke Kennard’s shooting, Santi Aldama’s versatility, and Derrick Rose’s veteran savvy provide stability and scoring when the starters rest. Offensively, the Grizzlies will aim to push the pace after defensive stops, hunting early transition opportunities before New Orleans can set its defense. When slowed into half-court play, Memphis will rely on movement and patience to exploit mismatches and open perimeter looks. They’ll need to stay disciplined, as overhelping against the Pelicans’ drive-heavy attack can open kick-out opportunities that swing momentum quickly. Expect Memphis to emphasize rebounding as well; securing the glass and limiting the Pelicans to one shot per possession will be critical to maintaining control. If the Grizzlies’ defense remains locked in and their secondary scorers find rhythm early, Memphis can build separation and dictate the pace. This game also serves as a measuring stick for their continued evolution—how well they blend their trademark toughness with improved offensive efficiency and composure in crunch time. With Morant’s explosiveness, Bane’s consistency, and Jackson’s interior presence, the Grizzlies have the tools to make life difficult for New Orleans and protect their home floor. If they execute their defensive schemes, capitalize on turnovers, and keep their offensive spacing fluid, Memphis will be well-positioned to open their season with an emphatic statement win that reaffirms their place among the conference’s most complete teams.
🐻 vs 🐝
— Memphis Grizzlies (@memgrizz) October 15, 2025
📺 @FDSN_Grizzlies
📻 @929espn
🕐 6:00pm
🆚 @hornets pic.twitter.com/pTrWkfEfaY
New Orleans vs Memphis Prop Picks (AI)
AI algorithm Remi is pouring through loads of data on each player. In fact, anytime the Pelicans and Grizzlies play there’s always several intriguing angles to key in on. Not to mention games played at FedExForum in Oct can often follow normal, predictable patterns.
New Orleans vs Memphis Prediction (AI)
Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every simulation between the Pelicans and Grizzlies and using recursive machine learning and impressive AI to examine the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most keyed in on the linear correlation of factor knucklehead sportsbettors often put on New Orleans’s strength factors between a Pelicans team going up against a possibly strong Grizzlies team. Trends look to say the true game analytics might reflect a strong lean against one Vegas line specifically.
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Below is our current AI New Orleans vs Memphis picks, computer picks Pelicans vs Grizzlies, best bets, model edges, confidence ratings.
| DATE | GAME | LEAN | %WIN | UNITS | LEVEL | |
|---|---|---|---|---|---|---|
| NBA | 11/25 | LAC@LAL | UNLOCK THIS PICK | 6 |
VAULT v3
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| NBA | 11/25 | ORL@PHI | UNLOCK THIS PICK | 3 |
EXECUTIVE
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These picks update as information changes—injury reports, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NBA schedule.
New Orleans Betting Trends
The Pelicans have a recent track record of 46–41–1 against the spread.
Memphis Betting Trends
The Grizzlies posted a 40–42 ATS mark in their recent campaigns.
Pelicans vs. Grizzlies Matchup Trends
When Memphis is favored at home, lines often assume they’ll dominate inside, making over-reliance on the paint sometimes aggressive. New Orleans has occasionally covered on the road when they force uptempo games and make Memphis uncomfortable in transition. Grizzlies’ home ATS is stronger than their overall splits, giving them a built-in edge in familiar settings.
New Orleans vs. Memphis Game Info
New Orleans vs Memphis starts on October 22, 2025 at 8:00 PM.
Venue: FedExForum.
Spread: Memphis -3.5
Moneyline: New Orleans +137, Memphis -163
Over/Under: 234.5
New Orleans: (0-0) | Memphis: (0-0)
Remi's searched hard and found the best prop for this matchup: J. Poole over 18.5 PTS+AST.. Prices move—always shop for the best number.
When Memphis is favored at home, lines often assume they’ll dominate inside, making over-reliance on the paint sometimes aggressive. New Orleans has occasionally covered on the road when they force uptempo games and make Memphis uncomfortable in transition. Grizzlies’ home ATS is stronger than their overall splits, giving them a built-in edge in familiar settings.
NO trend: The Pelicans have a recent track record of 46–41–1 against the spread.
MEM trend: The Grizzlies posted a 40–42 ATS mark in their recent campaigns.
See our latest NBA picks and odds pages for 2025 to compare prices before you bet.
New Orleans vs. Memphis Odds
Remi is pouring through loads of data points on each line. In fact, anytime the New Orleans vs Memphis trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance can often follow normal, predictable betting trends.
| NO Moneyline | +137 |
|---|---|
| MEM Moneyline | -163 |
| NO Spread | +3.5 |
| MEM Spread | -3.5 |
| Over / Under | 234.5 |
New Orleans vs Memphis Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Nov 26, 2025 5:10PM EST
Detroit Pistons
Boston Celtics
11/26/25 5:10PM
Pistons
Celtics
|
–
–
|
-150
+130
|
-2.5 (-110)
+2.5 (-110)
|
O 231.5 (-110)
U 231.5 (-110)
|
|
|
Nov 26, 2025 7:10PM EST
New York Knicks
Charlotte Hornets
11/26/25 7:10PM
Knicks
Hornets
|
–
–
|
-260
+215
|
-6.5 (-115)
+6.5 (-105)
|
O 239.5 (-110)
U 239.5 (-110)
|
|
|
Nov 26, 2025 7:40PM EST
Indiana Pacers
Toronto Raptors
11/26/25 7:40PM
Pacers
Raptors
|
–
–
|
+350
-480
|
+10.5 (-110)
-10.5 (-110)
|
O 235 (-110)
U 235 (-110)
|
|
|
Nov 26, 2025 7:40PM EST
Minnesota Timberwolves
Oklahoma City Thunder
11/26/25 7:40PM
Timberwolves
Thunder
|
–
–
|
+280
-360
|
+8.5 (-105)
-8.5 (-115)
|
O 226.5 (-110)
U 226.5 (-110)
|
|
|
Nov 26, 2025 7:40PM EST
Milwaukee Bucks
Miami Heat
11/26/25 7:40PM
Bucks
Heat
|
–
–
|
+250
-300
|
+8 (-110)
-8 (-110)
|
O 237.5 (-115)
U 237.5 (-105)
|
|
|
Nov 26, 2025 8:10PM EST
Memphis Grizzlies
New Orleans Pelicans
11/26/25 8:10PM
Grizzlies
Pelicans
|
–
–
|
-150
+130
|
-3 (-110)
+3 (-110)
|
O 235.5 (-110)
U 235.5 (-110)
|
|
|
Nov 26, 2025 10:10PM EST
Phoenix Suns
Sacramento Kings
11/26/25 10:10PM
Suns
Kings
|
–
–
|
-180
+155
|
-4.5 (-110)
+4.5 (-110)
|
O 233 (-110)
U 233 (-110)
|
|
|
Nov 26, 2025 10:10PM EST
San Antonio Spurs
Portland Trail Blazers
11/26/25 10:10PM
Spurs
Trail Blazers
|
–
–
|
-105
-115
|
+1 (-110)
-1 (-110)
|
O 239.5 (-110)
U 239.5 (-110)
|
|
|
Nov 26, 2025 10:10PM EST
Houston Rockets
Golden State Warriors
11/26/25 10:10PM
Rockets
Warriors
|
–
–
|
+125
-145
|
+2.5 (-110)
-2.5 (-110)
|
O 225 (-110)
U 225 (-110)
|
NBA Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers New Orleans Pelicans vs. Memphis Grizzlies on October 22, 2025 at FedExForum.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NBA odds pages, and compare prices before you place a bet.
| LEAN | %WIN | UNITS | RESULT | |
|---|---|---|---|---|
| DET@ATL | DET +1.5 | 54.3% | 4 | WIN |
| GS@ORL | ORL +3.5 | 57.4% | 7 | WIN |
| DET@ATL | JALEN DUREN UNDER 22.5 PTS + ASSTS | 55.1% | 5 | LOSS |
| BOS@BKN | MICHAEL PORTER JR UNDER 26.5 PTS + ASSTS | 54.4% | 4 | LOSS |
| IND@DET | DET -10.5 | 55.3% | 5 | WIN |
| NY@MIA | NY +2.5 | 51.8% | 1 | WIN |
| LAC@PHI | LAC +5.5 | 55.3% | 5 | WIN |
| LAC@PHI | IVICA ZUBAC OVER 1.5 STEALS & BLOCKS | 54.4% | 4 | LOSS |
| ORL@HOU | HOU -7.5 | 54.0% | 4 | LOSS |
| POR@DAL | DAL +4.5 | 56.8% | 6 | WIN |
| LAL@MIL | LAL -115 | 55.7% | 4 | WIN |
| CHA@MIL | MIL -9 | 54.4% | 4 | WIN |
| POR@HOU | POR +8 | 54.4% | 4 | LOSS |
| POR@HOU | TARI EASON OVER 4.5 FG MADE | 53.7% | 3 | LOSS |
| ATL@UTA | UTA +2.5 | 55.0% | 5 | LOSS |
| ATL@UTA | KYLE FILIPOWSKI OVER 7.5 REBOUNDS + ASSTS | 55.5% | 5 | WIN |
| NJ@CHI | JACK HUGHES UNDER 0.5 ASST | 54.4% | 4 | WIN |
| WAS@HOU | KEVIN DURANT OVER 4.5 REBOUNDS | 56.1% | 6 | WIN |
| GS@SA | GS +4 | 52.5% | 2 | WIN |
| MEM@BOS | MEM +7.5 | 56.0% | 6 | LOSS |
| BOS@PHI | PHI +1.5 | 54.5% | 4 | WIN |
| IND@UTA | UTA +3 | 56.8% | 6 | WIN |
| GS@OKC | CHET HOLMGREN UNDER 18.5 POINTS + ASSTS | 54.4% | 4 | LOSS |
| MIN@UTA | MIN -7.5 | 54.9% | 4 | LOSS |
| MIL@DAL | DAL +3 | 54.3% | 4 | WIN |
| POR@MIA | POR -3.5 | 57.7% | 7 | LOSS |
| LAL@ATL | DYSON DANIELS OVER 2.5 STEALS | 56.8% | 6 | LOSS |
| CHI@MIL | CHI +4.5 | 55.1% | 6 | LOSS |
| DAL@MEM | MEM -4 | 56.3% | 6 | WIN |
| TOR@ATL | TOR +118 | 48.0% | 3 | WIN |
| CHA@MIA | OVER 235.5 | 54.3% | 3 | LOSS |
| LAC@PHX | PHX -135 | 58.9% | 7 | WIN |
| PHI@CLE | PHI +10.5 | 53.3% | 3 | LOSS |
| MIA@DEN | MIA +9.5 | 53.7% | 3 | LOSS |
| OKC@POR | POR +4.5 | 52.9% | 3 | WIN |
| HOU@MEM | MEM +8.5 | 54.7% | 4 | LOSS |
| UTA@DET | UTA +10 | 56.8% | 6 | LOSS |
| NO@DAL | TREY MURPHY III OVER 25.5 PTS & REB | 55.5% | 5 | LOSS |
| ORL@ATL | ORL -3.5 | 56.5% | 6 | LOSS |
| MIL@TOR | MIL +3.5 | 56.5% | 4 | LOSS |
| PHX@GS | STEPH CURRY UNDER 4.5 THREE PTRS MADE | 53.3% | 3 | LOSS |
| OKC@LAC | JAMES HARDEN OVER 12.5 REBOUNDS + ASSTS | 56.1% | 6 | LOSS |
| LAL@POR | POR -2.5 | 54.7% | 4 | LOSS |
| SA@PHX | SA -5.5 | 56.6% | 6 | LOSS |
| ORL@WAS | WAS +9 | 54.2% | 4 | LOSS |
| DAL@DET | DAL +8 | 58.7% | 8 | LOSS |
| NY@CHI | NY -4.5 | 54.7% | 4 | LOSS |
| BOS@PHI | BOS +1.5 | 54.6% | 4 | WIN |
| TOR@CLE | TOR +6 | 56.2% | 6 | WIN |
| DEN@POR | JERAMI GRANT OVER 1.5 TURNOVERS | 56.6% | 6 | WIN |
| WAS@OKC | WAS +15.5 | 54.9% | 4 | LOSS |