Pittsburgh carries a five-game winning streak and fresh 2-0 shutout into Wednesday, while St. Louis sends 5.36-ERA lefty Matthew Liberatore against a Pirates club leaning on Lake Bachar and a strong bullpen.
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| Sportsbook | Spread | Moneyline | Total |
|---|---|---|---|
| FanDuel | STL -1.5 PIT +1.5 | STL +100 PIT -118 | O 7.5 U 7.5 |
| DraftKings | STL -1.5 PIT +1.5 | STL +100 PIT -121 | O 7.5 U 7.5 |
| BetMGM | STL -1.5 PIT +1.5 | STL +100 PIT -120 | O 7.5 U 7.5 |
| BetRivers | STL -1.5 PIT +1.5 | STL -114 PIT -106 | O 7.5 U 7.5 |
| Fanatics | STL -1.5 PIT +1.5 | STL +100 PIT -120 | O 7.5 U 7.5 |
| Bovada | STL -1.5 PIT +1.5 | STL -101 PIT -119 | O 7.5 U 7.5 |
| BetOnline.ag | STL +1.5 PIT -1.5 | STL +106 PIT -117 | O 7.5 U 7.5 |
| LowVig.ag | STL +1.5 PIT -1.5 | STL +106 PIT -117 | O 7.5 U 7.5 |
| MyBookie.ag | STL -1.5 PIT +1.5 | STL -102 PIT -115 | O 7.5 U 7.5 |
| Caesars | STL -1.5 PIT +1.5 | STL -104 PIT -113 | O 7.5 U 7.5 |
Injury Report
St. Louis remains without Joshua Baez, whose left oblique strain ended his season, while Blaze Jordan and Everson Pereira are still sidelined and Hunter Dobbins is out long term after elbow surgery. Pittsburgh is missing Esmerlyn Valdez because of a hamstring strain and has rotation depth reduced by Braxton Ashcraft and Mitch Keller. Kirby Yates returned Tuesday, strengthening the Pirates bullpen.
Key Players
Key Matchup Edge
Pittsburgh owns the clearer pitching edge. Bachar brings a 3.56 ERA and 1.14 WHIP against a St. Louis lineup coming off a one-hit shutout, while Liberatore carries a 5.36 ERA and 1.49 WHIP into a Pirates offense that has scored at least four runs in four of its last five.
3 Things to Watch
- Bachar efficiency against St. Louis power
- Liberatore traffic against Pittsburgh's power core
- Pittsburgh bullpen freshness after seven Jones innings
Betting Breakdown
Pittsburgh enters Wednesday with the stronger short-term profile, riding a five-game winning streak and coming off a 2-0 shutout in which St. Louis managed one hit. The Pirates are around -115 to -121 on the moneyline with a 7.5 total, a modest price that reflects both momentum and a pitching advantage. Lake Bachar brings a 3.56 ERA and 1.14 WHIP, while Matthew Liberatore owns a 5.36 ERA and 1.49 WHIP across 149 1/3 innings. That gap matters against a Pittsburgh offense with 181 homers and a .405 slugging percentage, compared with St. Louis at 161 homers and .380. The Cardinals still lead the season series 6-5, but Pittsburgh has won five of the last six meetings and three straight. St. Louis has been the better full-season run-line team at 84-73, yet Pittsburgh has covered six straight at home. For bettors, the core question is whether Liberatore can keep traffic down long enough for the Cardinals to reach Pittsburgh's stronger late-inning relief group.
St. Louis Betting Outlook
St. Louis needs an immediate offensive reset after producing one hit and no runs Tuesday. Alec Burleson remains the lineup's steadiest threat at .280 with 111 RBI, while Jordan Walker supplies team-best power with 28 homers. The bigger betting concern is Liberatore, whose 5.36 ERA, 1.49 WHIP and 27 home runs allowed leave little margin against a Pittsburgh lineup that has been rolling. The Cardinals are 38-38 on the road and 84-73 overall on the run line, so they have shown underdog resilience over the full season. Still, recent form is poor at 1-4 over the last five. St. Louis' path is to force Bachar into traffic early and avoid letting Pittsburgh hand a lead to its rested bullpen.
Pittsburgh Betting Outlook
Pittsburgh has the cleaner recent profile: five straight wins, a 43-36 home record and six consecutive home run-line covers. Brandon Lowe anchors the power with 33 homers and 93 RBI, while Bryan Reynolds continues to set the table with a .365 on-base percentage. Bachar's 3.56 ERA and 1.14 WHIP give the Pirates a steadier opening matchup than St. Louis gets from Liberatore, and Tuesday's seven scoreless innings from Jared Jones kept the bullpen workload manageable. Pittsburgh has also won five of the last six head-to-head meetings, trimming St. Louis' season-series edge to one game. The main risk is a short Bachar outing that exposes more middle relief than planned, but the home side enters in better form.
Latest Team Buzz
We love you, St. Louis! ❤️ pic.twitter.com/Ltnu8hieka
— St. Louis Cardinals (@Cardinals) September 20, 2026
W in the cards tonight. 🃏 pic.twitter.com/3Bh93HHpo4
— Pittsburgh Pirates (@Pirates) September 23, 2026
St. Louis Cardinals vs Pittsburgh Pirates FAQ
What is the current spread for St. Louis Cardinals vs Pittsburgh Pirates?
The current home spread is PIT +1.5, while the away spread is STL -1.5.
How far has the spread moved for St. Louis Cardinals vs Pittsburgh Pirates?
The spread opened at PIT -1.5 and is now PIT +1.5.
What is the current moneyline for St. Louis Cardinals vs Pittsburgh Pirates?
The current moneyline is STL +100 / PIT -121.
How far has the moneyline moved for St. Louis Cardinals vs Pittsburgh Pirates?
The moneyline opened at STL +100 / PIT -121 and is now STL +100 / PIT -121.
What is the current total for St. Louis Cardinals vs Pittsburgh Pirates?
The current total is 7.5.
How far has the total moved for St. Louis Cardinals vs Pittsburgh Pirates?
The total opened at 7.5 and is now 7.5.
Is the market taking the underdog in St. Louis Cardinals vs Pittsburgh Pirates?
Current market signal: Market Steady.
Is the market taking the favorite in St. Louis Cardinals vs Pittsburgh Pirates?
Current market signal: Market Steady.
Is the total dropping for St. Louis Cardinals vs Pittsburgh Pirates?
Current totals signal: Total Steady.
Is the total rising for St. Louis Cardinals vs Pittsburgh Pirates?
Current totals signal: Total Steady.
Where to watch St. Louis Cardinals vs Pittsburgh Pirates?
You can watch this game on SportsNet Pittsburgh. For the latest broadcast details, see Where to Watch.
Where to stream St. Louis Cardinals vs Pittsburgh Pirates?
You can stream this game on SNP 360.
What is the best free prop bet for St. Louis Cardinals vs Pittsburgh Pirates?
Brandon Lowe Over 5.5 Fantasy Score
What is the biggest matchup edge for St. Louis Cardinals vs Pittsburgh Pirates?
Pittsburgh owns the clearer pitching edge. Bachar brings a 3.56 ERA and 1.14 WHIP against a St. Louis lineup coming off a one-hit shutout, while Liberatore carries a 5.36 ERA and 1.49 WHIP into a Pirates offense that has scored at least four runs in four of its last five.
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