Cardinals vs. Cubs
Prediction, Odds & Props
Sep 28 | MLB AI Picks

Updated: 2025-09-26T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The St. Louis Cardinals visit the Chicago Cubs on September 28, 2025, in the final regular season meeting of a long-standing rivalry. With the Cubs jockeying for playoff positioning and the Cardinals playing with pride, this matchup blends history, urgency, and opportunity.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 28, 2025

Start Time: 7:10 PM EST​

Venue: Wrigley Field​

Cubs Record: (91-70)

Cardinals Record: (78-83)

OPENING ODDS

STL Moneyline: +139

CHC Moneyline: -167

STL Spread: +1.5

CHC Spread: -2

Over/Under: +8

STL
Betting Trends

  • The Cardinals have struggled to consistently cover on the road lately, often being outmatched by more potent offenses in hostile parks.

CHC
Betting Trends

  • The Cubs have generally held the line at home, especially late in the season when the stakes are heightened and they’ve treated Wrigley Field as a fortress.

MATCHUP TRENDS

  • In recent head-to-heads, the Cubs have covered more often when favored at home, and totals in Cubs-Cardinals games tilt slightly toward the “over,” especially when both teams press late in September.

STL vs. CHC
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Walker over 3.5 Fantasy Score.

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St. Louis vs Chicago Prediction & Odds:
Free MLB Betting Insights for 9/28/25

The upcoming matchup between the St. Louis Cardinals and the Chicago Cubs on September 28, 2025, at Wrigley Field is more than just another late-season MLB game—it’s the final chapter of one of baseball’s most iconic rivalries this year, and the stakes couldn’t be more contrasting. For the Cubs, this game has playoff implications as they aim to solidify their postseason berth and potentially improve their seeding, while the Cardinals enter with pride on the line, eager to finish strong and play spoiler against their oldest rival. Both teams have had very different journeys through the season, but rivalry games tend to erase records and highlight effort, execution, and momentum, and this contest sets up as a test of which side can maintain poise in a high-pressure environment. For Chicago, the strength of their season has come from a balanced offense and strong performances at home, with Seiya Suzuki, Michael Busch, and Pete Crow-Armstrong providing the offensive spark. The Cubs’ lineup has shown the ability to grind out at-bats, hit for power, and apply pressure with baserunning, which gives them an edge when facing weaker pitching staffs like St. Louis’. Their pitching has been steady enough, though not without concern, as they’ve leaned heavily on bullpen depth to carry them through tight contests, and that pen will be called upon again in this rivalry clash. The Cardinals, however, are no strangers to grinding out rivalry games, and even in a down season, they remain a threat because of their veteran leadership and ability to rise to the moment.

Players like Nolan Arenado and Paul Goldschmidt remain central to their offensive production, while Jordan Walker continues to grow into a cornerstone for the future. The challenge for St. Louis lies in their pitching, as inconsistency from both starters and relievers has plagued them all year, often turning winnable games into uphill battles. If their starter can deliver five to six solid innings and their bullpen limits mistakes, the Cardinals have the offensive firepower to keep this game close. Defensively, the Cubs have held the upper hand in recent head-to-head matchups, and that may play a critical role in what’s likely to be a tight, emotionally charged contest. The energy of Wrigley Field is another X-factor, as late September games with playoff implications turn the park into one of baseball’s most intimidating venues. For Chicago, the formula for victory is straightforward: score early, protect the lead with strong bullpen usage, and let the crowd carry them through late innings. For St. Louis, the key is patience at the plate, timely hitting, and capitalizing on any Cubs mistakes to make a playoff-bound team sweat under pressure. This game will not only be about execution but about pride and legacy, as both sides know the history of this rivalry adds weight to every pitch. Regardless of the standings, Cubs versus Cardinals always delivers drama, and this final clash of 2025 is no different—expect a fiercely contested game where every inning feels like October baseball.

St. Louis Cardinals MLB Preview

The St. Louis Cardinals come into this matchup against the Chicago Cubs with little left to play for in terms of postseason aspirations, but that does not mean they lack motivation, as beating their rivals at Wrigley Field to close out the season provides all the fuel they need. This season has been a turbulent one for St. Louis, marked by inconsistent pitching, stretches of offensive cold spells, and questions about how their veteran core fits into the team’s long-term future, yet in rivalry games records often matter less than the energy and grit on display. Offensively, the Cardinals still have dangerous pieces, with Nolan Arenado and Paul Goldschmidt anchoring the middle of the order and capable of punishing mistakes, while Jordan Walker has emerged as one of their most promising young stars and continues to show flashes of being a future franchise centerpiece. Their offense, though streaky, has been able to produce big innings when the lineup strings together patient at-bats, and against a Cubs pitching staff that has shown vulnerability late in games, the Cardinals’ best strategy may be to work counts and force Chicago into bullpen usage earlier than planned. Pitching remains the Cardinals’ biggest question mark, as their rotation has been plagued by inconsistency all season, often forcing the bullpen into extended work, and that has cost them in many close contests. Still, in a single rivalry game like this, one quality start from a young arm or even a journeyman veteran could make all the difference if they can hand the ball off with a lead.

Defensively, the Cardinals have not been as sharp as in years past, and that has only amplified their pitching struggles, so limiting mistakes in the field will be critical if they hope to stay competitive in what will surely be a charged atmosphere at Wrigley. Motivation may also come from within the clubhouse, as veterans like Goldschmidt and Arenado will want to show they can still carry the team in big games, while younger players will view this as an opportunity to prove they belong as foundational pieces for the future. Rivalry games often bring out unexpected heroes, and a player like Brendan Donovan or Tommy Edman could make a decisive impact with a clutch hit, a stolen base, or a defensive gem. The Cardinals’ mindset is not about October hopes but about pride, identity, and denying the Cubs momentum as they head into the playoffs, and in that sense, this game holds tremendous meaning for the franchise. If St. Louis can weather the storm of the Cubs’ early offensive pushes, manufacture some runs through opportunistic hitting, and avoid costly bullpen meltdowns, they can very well play spoiler and remind their rivals that even in a disappointing season, the Cardinals never stop fighting. For fans, seeing St. Louis leave Wrigley with a win to close out 2025 would be a reminder that this rivalry always matters, and for the players, it’s about setting the tone for the offseason and proving that this team’s pride cannot be underestimated.

The St. Louis Cardinals visit the Chicago Cubs on September 28, 2025, in the final regular season meeting of a long-standing rivalry. With the Cubs jockeying for playoff positioning and the Cardinals playing with pride, this matchup blends history, urgency, and opportunity. St. Louis vs Chicago AI Prediction: Free MLB Betting Insights for Sep 28. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Chicago Cubs MLB Preview

The Chicago Cubs enter this matchup against the St. Louis Cardinals with plenty on the line, as they remain focused on solidifying their postseason position while trying to close out the regular season with momentum. Unlike the Cardinals, who are mainly playing spoiler, the Cubs have the added weight of expectation, as their fan base knows that this young, exciting roster has the chance to do damage in October if they can stay healthy and consistent. Offensively, the Cubs have been driven by the continued rise of Cody Bellinger, who has rediscovered his power stroke and knack for timely hitting, while Nico Hoerner and Dansby Swanson provide a reliable combination of speed, defense, and situational hitting at the top and middle of the lineup. Their lineup also benefits from the balance of Seiya Suzuki and Christopher Morel, who bring both pop and versatility, giving the Cubs the ability to produce runs in a variety of ways, from manufacturing opportunities with small ball to slugging their way through innings. Pitching has been a key storyline for Chicago, as Justin Steele continues to cement himself as an ace, while the emergence of young arms has stabilized the rotation, though the team’s success in this game may hinge on how deep their starter can go before handing it off to a bullpen that has shown both dominance and inconsistency at times.

The back end of the bullpen, anchored by Adbert Alzolay, has been more stable lately, and in a rivalry game where late innings are often the difference, having reliable relievers to lock down high-leverage situations could tilt the scales in Chicago’s favor. Defensively, the Cubs are one of the more disciplined and fundamentally sound teams in baseball, with Swanson setting the tone at shortstop and Bellinger’s flexibility in the field providing them with options to cover any holes that arise. Beyond the X’s and O’s, this game means more because it’s against the Cardinals, a rivalry that has shaped the culture of both organizations for generations, and with the Cubs looking toward October, a victory here would not only keep their playoff hopes steady but also reinforce their mental edge by asserting dominance over their longtime rival. Manager Craig Counsell has emphasized discipline and balance all year, and that approach will be crucial in keeping the Cubs from letting the pressure of playoff implications impact their execution. Fans at Wrigley Field will provide a postseason-like atmosphere, knowing this is more than just another regular-season game, and the Cubs will be feeding off that energy as they aim to carry their confidence into the playoffs. If Chicago can capitalize on the Cardinals’ pitching vulnerabilities, maintain their defensive sharpness, and get timely production from their stars, they should be well positioned to secure a win that strengthens both their playoff seeding and their momentum heading into the most important stretch of the year. Ultimately, this game is about more than just standings—it’s about proving that this Cubs team has the maturity, resilience, and edge needed to transition from regular-season success into October relevance.

St. Louis vs. Chicago Prop Picks (AI)

Remi is pouring through tons of datapoints on each line. In fact, anytime the Cardinals and Cubs play there’s always several intriguing trends to key in on. Not to mention games played at Wrigley Field in Sep rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: J. Walker over 3.5 Fantasy Score.

St. Louis vs. Chicago Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every past game between the Cardinals and Cubs and using recursive machine learning and impressive AI to crunch the data to a single cover probability.

Interestingly enough, the data has been most fixated on the unproportionally assigned emphasis human bettors often put on St. Louis’s strength factors between a Cardinals team going up against a possibly rested Cubs team. It appears the true game analytics appear to reflect a slight lean against one Vegas line in particular.

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Below is our current AI St. Louis vs Chicago picks, computer picks Cardinals vs Cubs, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 BOS@NYY UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 CIN@LAD GET FREE PICK NOW 1
MLB 10/1 BOS@NYY UNLOCK THIS PICK 0 INTEL Locked INTEL
MLB 10/1 BOS@NYY GET FREE PICK NOW 0

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cardinals Betting Trends

The Cardinals have struggled to consistently cover on the road lately, often being outmatched by more potent offenses in hostile parks.

Cubs Betting Trends

The Cubs have generally held the line at home, especially late in the season when the stakes are heightened and they’ve treated Wrigley Field as a fortress.

Cardinals vs. Cubs Matchup Trends

In recent head-to-heads, the Cubs have covered more often when favored at home, and totals in Cubs-Cardinals games tilt slightly toward the “over,” especially when both teams press late in September.

St. Louis vs. Chicago Game Info

St. Louis vs Chicago starts on September 28, 2025 at 7:10 PM EST.

Spread: Chicago -2
Moneyline: St. Louis +139, Chicago -167
Over/Under: +8

St. Louis: (78-83)  |  Chicago: (91-70)

Remi's searched hard and found the best prop for this matchup: J. Walker over 3.5 Fantasy Score.. Prices move—always shop for the best number.

In recent head-to-heads, the Cubs have covered more often when favored at home, and totals in Cubs-Cardinals games tilt slightly toward the “over,” especially when both teams press late in September.

STL trend: The Cardinals have struggled to consistently cover on the road lately, often being outmatched by more potent offenses in hostile parks.

CHC trend: The Cubs have generally held the line at home, especially late in the season when the stakes are heightened and they’ve treated Wrigley Field as a fortress.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Chicago Odds

Remi is pouring through tons of data points on each player. In fact, anytime the St. Louis vs Chicago trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable betting trends.

St. Louis vs Chicago Opening Odds

STL Moneyline: +139
CHC Moneyline: -167
STL Spread: +1.5
CHC Spread: -2
Over/Under: +8

St. Louis vs Chicago Live Odds

Games PTS ML SPR O/U
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
+100
-120
-1.5 (+175)
+1.5 (-215)
O 7 (-105)
U 7 (-115)
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
+100
-118
-1.5 (+172)
+1.5 (-210)
O 7.5 (-110)
U 7.5 (-110)
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
+136
-162
+1.5 (-160)
-1.5 (+130)
O 7.5 (-120)
U 7.5 (-102)
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
+110
-130
pk
pk
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
+108
-126
pk
pk
O 7 (-135)
U 7 (+115)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Cardinals vs. Chicago Cubs on September 28, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS