Cardinals vs. Cubs
Prediction, Odds & Props
Sep 28 | MLB AI Picks
Updated: 2025-09-26T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The St. Louis Cardinals visit the Chicago Cubs on September 28, 2025, in the final regular season meeting of a long-standing rivalry. With the Cubs jockeying for playoff positioning and the Cardinals playing with pride, this matchup blends history, urgency, and opportunity.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 28, 2025
Start Time: 7:10 PM EST
Venue: Wrigley Field
Cubs Record: (91-70)
Cardinals Record: (78-83)
OPENING ODDS
STL Moneyline: +139
CHC Moneyline: -167
STL Spread: +1.5
CHC Spread: -2
Over/Under: +8
STL
Betting Trends
- The Cardinals have struggled to consistently cover on the road lately, often being outmatched by more potent offenses in hostile parks.
CHC
Betting Trends
- The Cubs have generally held the line at home, especially late in the season when the stakes are heightened and they’ve treated Wrigley Field as a fortress.
MATCHUP TRENDS
- In recent head-to-heads, the Cubs have covered more often when favored at home, and totals in Cubs-Cardinals games tilt slightly toward the “over,” especially when both teams press late in September.
STL vs. CHC
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Walker over 3.5 Fantasy Score.
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St. Louis vs Chicago Prediction & Odds:
Free MLB Betting Insights for 9/28/25
Players like Nolan Arenado and Paul Goldschmidt remain central to their offensive production, while Jordan Walker continues to grow into a cornerstone for the future. The challenge for St. Louis lies in their pitching, as inconsistency from both starters and relievers has plagued them all year, often turning winnable games into uphill battles. If their starter can deliver five to six solid innings and their bullpen limits mistakes, the Cardinals have the offensive firepower to keep this game close. Defensively, the Cubs have held the upper hand in recent head-to-head matchups, and that may play a critical role in what’s likely to be a tight, emotionally charged contest. The energy of Wrigley Field is another X-factor, as late September games with playoff implications turn the park into one of baseball’s most intimidating venues. For Chicago, the formula for victory is straightforward: score early, protect the lead with strong bullpen usage, and let the crowd carry them through late innings. For St. Louis, the key is patience at the plate, timely hitting, and capitalizing on any Cubs mistakes to make a playoff-bound team sweat under pressure. This game will not only be about execution but about pride and legacy, as both sides know the history of this rivalry adds weight to every pitch. Regardless of the standings, Cubs versus Cardinals always delivers drama, and this final clash of 2025 is no different—expect a fiercely contested game where every inning feels like October baseball.
A blast into the bleachers by Walker! pic.twitter.com/vhDGgjK97s
— St. Louis Cardinals (@Cardinals) September 27, 2025
St. Louis Cardinals MLB Preview
The St. Louis Cardinals come into this matchup against the Chicago Cubs with little left to play for in terms of postseason aspirations, but that does not mean they lack motivation, as beating their rivals at Wrigley Field to close out the season provides all the fuel they need. This season has been a turbulent one for St. Louis, marked by inconsistent pitching, stretches of offensive cold spells, and questions about how their veteran core fits into the team’s long-term future, yet in rivalry games records often matter less than the energy and grit on display. Offensively, the Cardinals still have dangerous pieces, with Nolan Arenado and Paul Goldschmidt anchoring the middle of the order and capable of punishing mistakes, while Jordan Walker has emerged as one of their most promising young stars and continues to show flashes of being a future franchise centerpiece. Their offense, though streaky, has been able to produce big innings when the lineup strings together patient at-bats, and against a Cubs pitching staff that has shown vulnerability late in games, the Cardinals’ best strategy may be to work counts and force Chicago into bullpen usage earlier than planned. Pitching remains the Cardinals’ biggest question mark, as their rotation has been plagued by inconsistency all season, often forcing the bullpen into extended work, and that has cost them in many close contests. Still, in a single rivalry game like this, one quality start from a young arm or even a journeyman veteran could make all the difference if they can hand the ball off with a lead.
Defensively, the Cardinals have not been as sharp as in years past, and that has only amplified their pitching struggles, so limiting mistakes in the field will be critical if they hope to stay competitive in what will surely be a charged atmosphere at Wrigley. Motivation may also come from within the clubhouse, as veterans like Goldschmidt and Arenado will want to show they can still carry the team in big games, while younger players will view this as an opportunity to prove they belong as foundational pieces for the future. Rivalry games often bring out unexpected heroes, and a player like Brendan Donovan or Tommy Edman could make a decisive impact with a clutch hit, a stolen base, or a defensive gem. The Cardinals’ mindset is not about October hopes but about pride, identity, and denying the Cubs momentum as they head into the playoffs, and in that sense, this game holds tremendous meaning for the franchise. If St. Louis can weather the storm of the Cubs’ early offensive pushes, manufacture some runs through opportunistic hitting, and avoid costly bullpen meltdowns, they can very well play spoiler and remind their rivals that even in a disappointing season, the Cardinals never stop fighting. For fans, seeing St. Louis leave Wrigley with a win to close out 2025 would be a reminder that this rivalry always matters, and for the players, it’s about setting the tone for the offseason and proving that this team’s pride cannot be underestimated.

Credit: USA TODAY/IMAGN
Chicago Cubs MLB Preview
The Chicago Cubs enter this matchup against the St. Louis Cardinals with plenty on the line, as they remain focused on solidifying their postseason position while trying to close out the regular season with momentum. Unlike the Cardinals, who are mainly playing spoiler, the Cubs have the added weight of expectation, as their fan base knows that this young, exciting roster has the chance to do damage in October if they can stay healthy and consistent. Offensively, the Cubs have been driven by the continued rise of Cody Bellinger, who has rediscovered his power stroke and knack for timely hitting, while Nico Hoerner and Dansby Swanson provide a reliable combination of speed, defense, and situational hitting at the top and middle of the lineup. Their lineup also benefits from the balance of Seiya Suzuki and Christopher Morel, who bring both pop and versatility, giving the Cubs the ability to produce runs in a variety of ways, from manufacturing opportunities with small ball to slugging their way through innings. Pitching has been a key storyline for Chicago, as Justin Steele continues to cement himself as an ace, while the emergence of young arms has stabilized the rotation, though the team’s success in this game may hinge on how deep their starter can go before handing it off to a bullpen that has shown both dominance and inconsistency at times.
The back end of the bullpen, anchored by Adbert Alzolay, has been more stable lately, and in a rivalry game where late innings are often the difference, having reliable relievers to lock down high-leverage situations could tilt the scales in Chicago’s favor. Defensively, the Cubs are one of the more disciplined and fundamentally sound teams in baseball, with Swanson setting the tone at shortstop and Bellinger’s flexibility in the field providing them with options to cover any holes that arise. Beyond the X’s and O’s, this game means more because it’s against the Cardinals, a rivalry that has shaped the culture of both organizations for generations, and with the Cubs looking toward October, a victory here would not only keep their playoff hopes steady but also reinforce their mental edge by asserting dominance over their longtime rival. Manager Craig Counsell has emphasized discipline and balance all year, and that approach will be crucial in keeping the Cubs from letting the pressure of playoff implications impact their execution. Fans at Wrigley Field will provide a postseason-like atmosphere, knowing this is more than just another regular-season game, and the Cubs will be feeding off that energy as they aim to carry their confidence into the playoffs. If Chicago can capitalize on the Cardinals’ pitching vulnerabilities, maintain their defensive sharpness, and get timely production from their stars, they should be well positioned to secure a win that strengthens both their playoff seeding and their momentum heading into the most important stretch of the year. Ultimately, this game is about more than just standings—it’s about proving that this Cubs team has the maturity, resilience, and edge needed to transition from regular-season success into October relevance.
HOW EXCITED ARE YOU RIGHT NOW CHICAGO?! pic.twitter.com/3HR1Aoqz0J
— Chicago Cubs (@Cubs) September 27, 2025
St. Louis vs. Chicago Prop Picks (AI)
St. Louis vs. Chicago Prediction (AI)

Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every past game between the Cardinals and Cubs and using recursive machine learning and impressive AI to crunch the data to a single cover probability.
Interestingly enough, the data has been most fixated on the unproportionally assigned emphasis human bettors often put on St. Louis’s strength factors between a Cardinals team going up against a possibly rested Cubs team. It appears the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI St. Louis vs Chicago picks, computer picks Cardinals vs Cubs, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 3 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | CIN@LAD | GET FREE PICK NOW | 1 | – | |
MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 0 |
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MLB | 10/1 | BOS@NYY | GET FREE PICK NOW | 0 | – |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Cardinals Betting Trends
The Cardinals have struggled to consistently cover on the road lately, often being outmatched by more potent offenses in hostile parks.
Cubs Betting Trends
The Cubs have generally held the line at home, especially late in the season when the stakes are heightened and they’ve treated Wrigley Field as a fortress.
Cardinals vs. Cubs Matchup Trends
In recent head-to-heads, the Cubs have covered more often when favored at home, and totals in Cubs-Cardinals games tilt slightly toward the “over,” especially when both teams press late in September.
St. Louis vs. Chicago Game Info
What time does St. Louis vs Chicago start on September 28, 2025?
St. Louis vs Chicago starts on September 28, 2025 at 7:10 PM EST.
Where is St. Louis vs Chicago being played?
Venue: Wrigley Field.
What are the opening odds for St. Louis vs Chicago?
Spread: Chicago -2
Moneyline: St. Louis +139, Chicago -167
Over/Under: +8
What are the records for St. Louis vs Chicago?
St. Louis: (78-83) | Chicago: (91-70)
What is the AI best bet for St. Louis vs Chicago?
Remi's searched hard and found the best prop for this matchup: J. Walker over 3.5 Fantasy Score.. Prices move—always shop for the best number.
What are St. Louis vs Chicago trending bets?
In recent head-to-heads, the Cubs have covered more often when favored at home, and totals in Cubs-Cardinals games tilt slightly toward the “over,” especially when both teams press late in September.
What are St. Louis trending bets?
STL trend: The Cardinals have struggled to consistently cover on the road lately, often being outmatched by more potent offenses in hostile parks.
What are Chicago trending bets?
CHC trend: The Cubs have generally held the line at home, especially late in the season when the stakes are heightened and they’ve treated Wrigley Field as a fortress.
Where can I find AI Picks for St. Louis vs Chicago?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
St. Louis vs. Chicago Odds
Remi is pouring through tons of data points on each player. In fact, anytime the St. Louis vs Chicago trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable betting trends.
St. Louis vs Chicago Opening Odds
STL Moneyline:
+139 CHC Moneyline: -167
STL Spread: +1.5
CHC Spread: -2
Over/Under: +8
St. Louis vs Chicago Live Odds
Games | PTS | ML | SPR | O/U | |
---|---|---|---|---|---|
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
|
–
–
|
+100
-120
|
-1.5 (+175)
+1.5 (-215)
|
O 7 (-105)
U 7 (-115)
|
|
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
|
–
–
|
+100
-118
|
-1.5 (+172)
+1.5 (-210)
|
O 7.5 (-110)
U 7.5 (-110)
|
|
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
|
–
–
|
+136
-162
|
+1.5 (-160)
-1.5 (+130)
|
O 7.5 (-120)
U 7.5 (-102)
|
|
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
|
–
–
|
+110
-130
|
pk
pk
|
|
|
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
|
–
–
|
+108
-126
|
pk
pk
|
O 7 (-135)
U 7 (+115)
|
MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers St. Louis Cardinals vs. Chicago Cubs on September 28, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |