Astros vs. Angels
Prediction, Odds & Props
Sep 28 | MLB AI Picks
Updated: 2025-09-26T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Houston Astros and Los Angeles Angels close out their weekend series on September 28, 2025, in Anaheim, with Houston looking to tighten its grip on playoff positioning and the Angels hoping to play spoiler while continuing to evaluate young talent. With October on the horizon, both teams will bring urgency, though for very different reasons.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 28, 2025
Start Time: 3:07 PM EST
Venue: Angel Stadium of Anaheim
Angels Record: (72-89)
Astros Record: (86-75)
OPENING ODDS
HOU Moneyline: LOADING
LAA Moneyline: LOADING
HOU Spread: LOADING
LAA Spread: LOADING
Over/Under: LOADING
HOU
Betting Trends
- The Astros have covered in six of their last ten road games, leaning on consistent pitching and timely hitting to maintain momentum.
LAA
Betting Trends
- The Angels have struggled at home recently, covering only three of their last ten contests at Angel Stadium.
MATCHUP TRENDS
- The under has cashed in seven of the last ten meetings between these clubs, as Houston’s pitching depth has often stifled Los Angeles’ inconsistent offense. Additionally, Houston has won eight of the last ten head-to-head matchups, asserting dominance in the division rivalry.
HOU vs. LAA
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: M. Trout over 5.5 Fantasy Score.
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Houston vs Los Angeles Prediction & Odds:
Free MLB Betting Insights for 9/28/25
Mike Trout, though nearing the twilight of his career, remains a steady presence when healthy, while younger bats like Jo Adell and Mickey Moniak are still trying to prove themselves as everyday options. Pitching continues to be a sore spot for Los Angeles, though Reid Detmers and Chase Silseth have shown glimpses of potential, and the bullpen has been inconsistent at best, often unable to hold leads even when the offense delivers. Strategically, the Astros will look to exploit these weaknesses by working deep counts and forcing Angels starters out of the game early, while the Angels must counter with aggressiveness at the plate, looking to capitalize on any mistakes from Houston’s pitching staff. Defensively, Houston’s experience and fundamentals give them an edge, particularly in close games where execution can be the difference between a win and a loss. While the Angels will be motivated to play spoiler, the Astros’ combination of depth, talent, and urgency for postseason positioning makes them the clear favorites, though baseball’s unpredictability means Los Angeles could still steal a win if their young bats catch fire or Houston shows signs of fatigue. Ultimately, this matchup is about more than just one game—it highlights the contrast between a team entrenched in championship contention and another still laying the foundation for future success.
2 homer night from Walker! #BuiltForThis x @budweiserusa pic.twitter.com/h5hHsLMpBr
— Houston Astros (@astros) September 28, 2025
Houston Astros MLB Preview
The Houston Astros enter Anaheim on September 28, 2025, with the postseason in sight and a clear objective to continue sharpening their form against a struggling Angels team that they have consistently handled in recent years. The Astros remain a model of consistency in the American League, with a veteran-laden roster that blends elite talent, playoff experience, and a winning culture built over nearly a decade of contention. Yordan Alvarez has been the centerpiece of Houston’s offense, his ability to change games with one swing making him one of the most feared hitters in the league. Kyle Tucker has complemented him perfectly, combining middle-of-the-order power with speed and defense that make him a well-rounded star. José Altuve continues to provide leadership, timely hitting, and the kind of consistency that has defined his Hall of Fame-caliber career, while Alex Bregman adds depth and playoff experience to an already formidable lineup. Emerging contributors like Jeremy Peña and Yainer Díaz further lengthen the order, ensuring that opposing pitchers never have an easy out from top to bottom. On the pitching side, Framber Valdez remains the ace, leaning on his elite sinker to induce ground balls and control games, while Cristian Javier and Hunter Brown add strikeout upside and durability.
The Astros’ bullpen has been one of their strengths, anchored by Ryan Pressly and Bryan Abreu, who have consistently locked down close games, giving Houston confidence in their ability to protect leads late. Defensively, the Astros are one of the most fundamentally sound teams in baseball, minimizing mistakes and excelling at situational execution, which often proves decisive in tightly contested games. Against the Angels, Houston’s approach will be to apply pressure early, forcing Los Angeles’ young pitching staff into high-stress innings and capitalizing on defensive lapses that have plagued the Angels throughout the season. Manager Joe Espada has emphasized the importance of entering October with rhythm and sharpness, meaning Houston is unlikely to take this game lightly despite facing a weaker opponent. The Astros will likely rotate their pitching staff to manage workloads, but their depth ensures that even secondary arms can be highly effective. Offensively, Houston’s patient approach will test the Angels’ pitching, creating opportunities for Alvarez and Tucker to deliver in run-producing situations. This game not only provides the Astros with a chance to solidify their playoff position but also serves as a rehearsal for the intensity and execution demanded in October. With their combination of star power, depth, and experience, Houston enters as heavy favorites, and a win here would be another step toward reinforcing their reputation as one of the premier franchises in Major League Baseball. For the Astros, it is not just about securing victory—it is about continuing to build momentum for the postseason and proving once again that they remain the standard of consistency in the American League.

Credit: USA TODAY/IMAGN
Los Angeles Angels MLB Preview
The Los Angeles Angels host the Houston Astros on September 28, 2025, with the reality that this game is more about pride and progress than postseason stakes, as the Angels once again find themselves on the outside looking in during late September. While years of mediocrity have frustrated their fan base, the organization has shifted its focus toward building around young talent that it hopes will eventually bring them back into contention. Mike Trout remains the most recognizable face of the franchise, and while injuries have limited his availability, his leadership and professionalism provide stability for a young roster still finding its identity. Behind him, players like Nolan Schanuel and Logan O’Hoppe have become integral pieces of the rebuild, with Schanuel showing impressive plate discipline and on-base skills while O’Hoppe brings power and defensive ability behind the plate. Zach Neto has been a spark at shortstop with his glove and contact bat, while Jo Adell, after years of inconsistency, is still fighting to cement his place as a reliable outfielder. The Angels’ lineup has flashes of potential but struggles with consistency, particularly against elite pitching staffs like Houston’s, where prolonged scoring droughts often leave the team vulnerable.
Pitching has long been the Angels’ Achilles heel, and while Reid Detmers and Chase Silseth have shown developmental strides, they remain prone to bouts of inefficiency that put pressure on a bullpen ill-equipped to handle high workloads. The bullpen, led sporadically by Carlos Estévez, has been plagued by inconsistency, allowing opponents to erase leads and steal momentum late in games. Against Houston, the Angels must find a way to score early and avoid falling into situations where they are chasing against one of the best bullpens in the league. At home, the Angels will benefit from the supportive Anaheim crowd, but they will need execution in all phases of the game—something that has been elusive throughout much of the 2025 season. Manager Ron Washington has emphasized fundamentals and accountability, but the results have been mixed, with the Angels often showing promise in spurts but lacking the sustained performance needed to compete against teams of Houston’s caliber. Still, this matchup presents an opportunity for the Angels’ young players to measure themselves against one of the best in baseball, and even in defeat, valuable experience can be gained. For the organization, every game at this point is about evaluation, culture-building, and instilling confidence in the pieces that will hopefully define their future. While Houston remains the favorite, the Angels’ task will be to showcase fight, steal momentum with timely hitting, and give their fans a glimpse of progress in a season defined by transition.
In honor of Fan Appreciation Night, we're giving away a signed @MikeTrout jersey! 🐐
— Los Angeles Angels (@Angels) September 28, 2025
Share this post by 5pm PT tomorrow (9/28) for your chance to win!
One winner will be randomly selected; link in bio for rules. pic.twitter.com/3PCw2VWYmm
Houston vs. Los Angeles Prop Picks (AI)
Houston vs. Los Angeles Prediction (AI)

Remi, our AI sports algorithm, has been pouring over millions of data from every angle between the Astros and Angels and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.
Interestingly enough, the data has been most focused on the growing emphasis emotional bettors regularly put on coaching factors between a Astros team going up against a possibly healthy Angels team. We’ve found the true game analytics might reflect a strong lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Houston vs Los Angeles picks, computer picks Astros vs Angels, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 3 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | CIN@LAD | GET FREE PICK NOW | 1 | – | |
MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 0 |
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MLB | 10/1 | BOS@NYY | GET FREE PICK NOW | 0 | – |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Astros Betting Trends
The Astros have covered in six of their last ten road games, leaning on consistent pitching and timely hitting to maintain momentum.
Angels Betting Trends
The Angels have struggled at home recently, covering only three of their last ten contests at Angel Stadium.
Astros vs. Angels Matchup Trends
The under has cashed in seven of the last ten meetings between these clubs, as Houston’s pitching depth has often stifled Los Angeles’ inconsistent offense. Additionally, Houston has won eight of the last ten head-to-head matchups, asserting dominance in the division rivalry.
Houston vs. Los Angeles Game Info
What time does Houston vs Los Angeles start on September 28, 2025?
Houston vs Los Angeles starts on September 28, 2025 at 3:07 PM EST.
Where is Houston vs Los Angeles being played?
Venue: Angel Stadium of Anaheim.
What are the opening odds for Houston vs Los Angeles?
Spread: Los Angeles LOADING
Moneyline: Houston LOADING, Los Angeles LOADING
Over/Under: LOADING
What are the records for Houston vs Los Angeles?
Houston: (86-75) | Los Angeles: (72-89)
What is the AI best bet for Houston vs Los Angeles?
Remi's searched hard and found the best prop for this matchup: M. Trout over 5.5 Fantasy Score.. Prices move—always shop for the best number.
What are Houston vs Los Angeles trending bets?
The under has cashed in seven of the last ten meetings between these clubs, as Houston’s pitching depth has often stifled Los Angeles’ inconsistent offense. Additionally, Houston has won eight of the last ten head-to-head matchups, asserting dominance in the division rivalry.
What are Houston trending bets?
HOU trend: The Astros have covered in six of their last ten road games, leaning on consistent pitching and timely hitting to maintain momentum.
What are Los Angeles trending bets?
LAA trend: The Angels have struggled at home recently, covering only three of their last ten contests at Angel Stadium.
Where can I find AI Picks for Houston vs Los Angeles?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Houston vs. Los Angeles Odds
AI algorithm Remi is pouring through loads of stats on each team. In fact, anytime the Houston vs Los Angeles trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable betting trends.
Houston vs Los Angeles Opening Odds
HOU Moneyline:
LOADING LAA Moneyline: LOADING
HOU Spread: LOADING
LAA Spread: LOADING
Over/Under: LOADING
Houston vs Los Angeles Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
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–
–
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+100
-120
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-1.5 (+175)
+1.5 (-215)
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O 7 (-105)
U 7 (-115)
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Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
|
–
–
|
+100
-118
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-1.5 (+172)
+1.5 (-210)
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O 7.5 (-110)
U 7.5 (-110)
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Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
|
–
–
|
+136
-162
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+1.5 (-160)
-1.5 (+130)
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O 7.5 (-120)
U 7.5 (-102)
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Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
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–
–
|
+110
-130
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pk
pk
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Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
|
–
–
|
+108
-126
|
pk
pk
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O 7 (-135)
U 7 (+115)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Houston Astros vs. Los Angeles Angels on September 28, 2025 at Angel Stadium of Anaheim.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |