Tigers vs. Sox
Prediction, Odds & Props
Sep 28 | MLB AI Picks
Updated: 2025-09-26T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Detroit Tigers travel to Fenway Park on September 28, 2025, to face the Boston Red Sox in what may be a pivotal late-season game as both clubs jockey for playoff positioning. Boston, having recently clinched a Wild Card berth, will look to keep momentum and fine-tune pieces, while Detroit, still alive in the postseason chase, needs every win it can get to solidify its spot.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 28, 2025
Start Time: 3:05 PM EST
Venue: Fenway Park
Sox Record: (88-73)
Tigers Record: (87-74)
OPENING ODDS
DET Moneyline: LOADING
BOS Moneyline: LOADING
DET Spread: LOADING
BOS Spread: LOADING
Over/Under: LOADING
DET
Betting Trends
- The Tigers have struggled against the spread this season, carrying a record near 72–87 ATS entering this matchup.
BOS
Betting Trends
- The Red Sox have fared better ATS, standing around 81–79 ATS this year.
MATCHUP TRENDS
- In recent head-to-head matchups at Fenway, betting trends have shown that Boston performs better than average as a home favorite, and that totals tend to lean over 8.5 when Detroit is on the road.
DET vs. BOS
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: W. Abreu under 1.5 Hits+Runs+RBI.
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Detroit vs Boston Red Prediction & Odds:
Free MLB Betting Insights for 9/28/25
They’ll look to Bryce Harper, Kyle Schwarber, and Alec Bohm to continue their offensive surge, while pitchers like Tanner Houck and Brayan Bello will be tasked with setting the tone early and neutralizing Detroit’s power bats. What makes this game particularly compelling is the contrast in motivation: Boston has secured its postseason spot but will want to sharpen its execution and maintain momentum, while Detroit is playing with its season on the line, desperately needing a win to remain in contention. These contrasting narratives create a high-stakes atmosphere at Fenway, where the crowd will be ready to celebrate Boston’s achievement but Detroit will arrive determined to silence them. The Tigers’ key to victory will be to strike early and apply pressure on Boston’s pitchers, forcing mistakes and trying to turn the game into a slugfest, while Boston will aim to control the tempo, execute clean defense, and let its superior depth shine through in the later innings. With the Red Sox favored, the Tigers will need grit, timely power, and perhaps some Fenway magic of their own to leave Boston with a much-needed win.
Ticket PUNCHED. pic.twitter.com/11hELHgtm9
— Detroit Tigers (@tigers) September 27, 2025
Detroit Tigers MLB Preview
The Detroit Tigers enter their September 28, 2025, matchup against the Boston Red Sox with an urgency that reflects their current standing in the American League playoff picture, as every inning of every game feels like a test of their ability to survive in a competitive race that has demanded consistency, resilience, and timely execution from all its participants. For Detroit, this game represents both a challenge and an opportunity: a chance to upset a Boston team that has already secured its postseason berth and is now fine-tuning its roster for October, but also a reminder that the Tigers’ margin for error is minimal. Offensively, the Tigers will once again look to Spencer Torkelson and Riley Greene, the young cornerstones of their lineup, who have shown flashes of brilliance throughout the season with their ability to provide power and drive in runs, but Detroit’s lineup has often been plagued by inconsistency, relying too much on big swings rather than sustained rallies. The supporting cast, including hitters like Kerry Carpenter and Colt Keith, must find ways to contribute, especially against Boston pitching that has been sharp at Fenway Park this season.
On the mound, Detroit faces its greatest test, as their rotation has been inconsistent, forcing manager A.J. Hinch to shuffle starters in hopes of catching the right matchup; the bullpen, meanwhile, has been particularly vulnerable in late innings, often struggling to protect slim leads or keep games close enough for the offense to rally. To win against Boston, Detroit must establish control early, ideally with a strong start from its rotation to buy the lineup time to adjust, because allowing Boston’s lineup multiple scoring opportunities at Fenway almost always spells defeat. The Tigers’ path to victory likely involves generating early offense, playing aggressive on the basepaths, and keeping Boston’s crowd subdued, because letting Fenway energy build has proven costly for visiting teams all season. While Detroit may feel the pressure of their dwindling postseason hopes, that urgency could also fuel them to play with a desperation and edge that Boston, with its playoff spot already secured, might not fully match. Yet the Tigers’ Achilles heel remains their bullpen, and unless it can find ways to hold leads or deliver shutdown innings, even a strong offensive performance could unravel late. Ultimately, this game represents Detroit’s chance to prove that their youth and rebuilding pieces can rise to the moment, but it will require their hitters to attack early, their pitchers to execute with precision, and their defense to remain sharp under pressure. Anything less risks leaving Fenway Park with another costly loss, which could very well put their postseason aspirations out of reach.

Credit: USA TODAY/IMAGN
Boston Red Sox MLB Preview
The Boston Red Sox step into their September 28, 2025, matchup against the Detroit Tigers at Fenway Park with the luxury of playing with confidence, as they’ve already secured a place in the postseason and are now focused on fine-tuning their lineup and rotation for October, a position that reflects the consistency and depth they’ve shown all year. For Boston, this game provides an opportunity to sharpen details, test matchups, and perhaps rest certain regulars while still maintaining their momentum heading into the playoffs. At the heart of their success has been Rafael Devers, who continues to anchor the middle of the lineup with his blend of power and clutch hitting, while Triston Casas and Jarren Duran have provided complementary offense that stretches the lineup and forces opposing pitchers to navigate multiple threats. Boston’s depth has been a hallmark of their 2025 season, as role players like Wilyer Abreu and Ceddanne Rafaela have stepped up in key moments, while veterans such as Trevor Story have contributed both offensively and defensively when healthy. On the pitching side, the Red Sox rotation has held firm thanks to the resurgence of Nick Pivetta and steady performances from young arms who have developed into reliable options throughout the grind of the season, and with the bullpen anchored by closer Kenley Jansen, Boston has found stability in the later innings.
Manager Alex Cora has emphasized situational execution and aggressive baserunning, an approach that has worn down opponents and consistently tilted games in Boston’s favor. Against Detroit, the Red Sox will aim to establish control early, using their patient approach at the plate to drive up pitch counts and exploit the Tigers’ pitching staff, which has struggled at times with command and depth. Fenway Park’s atmosphere will only add to the challenge for Detroit, as the Red Sox faithful have energized their team all season and will be eager to see their club close out the final week of the regular season on a strong note. Still, while Boston holds the edge on paper, the focus for Cora and his staff will be balancing the need to win with the necessity of keeping players healthy and managing workloads ahead of the playoffs. That balance may open the door for Detroit to hang around if the Red Sox experiment with lineup rotations or bullpen usage, but Boston’s depth gives them enough firepower to handle such adjustments without significantly lowering their odds of victory. In many ways, this game will serve as a postseason tune-up, a chance to keep rhythm while still experimenting with matchups, and if Boston continues to execute with the precision and energy they’ve shown for much of 2025, they should be well-positioned not only to dispatch Detroit but to carry momentum into October with confidence that they are battle-tested and ready for the challenges ahead.
Sogie gets things going! pic.twitter.com/JoMG4h47sj
— Red Sox (@RedSox) September 27, 2025
Detroit vs. Boston Red Prop Picks (AI)
Detroit vs. Boston Red Prediction (AI)

Remi, our AI sports algorithm, has been pouring over mountains of data from every simulation between the Tigers and Sox and using recursive machine learning and impressive AI to crunch the data to a single cover probability.
Remi has been most fixated on the trending emphasis knucklehead sportsbettors tend to put on Boston Red’s strength factors between a Tigers team going up against a possibly improved Sox team. In reality, the true game analytics appear to reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Detroit vs Boston Red picks, computer picks Tigers vs Sox, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 3 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | CIN@LAD | GET FREE PICK NOW | 1 | – | |
MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 0 |
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MLB | 10/1 | BOS@NYY | GET FREE PICK NOW | 0 | – |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Tigers Betting Trends
The Tigers have struggled against the spread this season, carrying a record near 72–87 ATS entering this matchup.
Sox Betting Trends
The Red Sox have fared better ATS, standing around 81–79 ATS this year.
Tigers vs. Sox Matchup Trends
In recent head-to-head matchups at Fenway, betting trends have shown that Boston performs better than average as a home favorite, and that totals tend to lean over 8.5 when Detroit is on the road.
Detroit vs. Boston Red Game Info
What time does Detroit vs Boston Red start on September 28, 2025?
Detroit vs Boston Red starts on September 28, 2025 at 3:05 PM EST.
Where is Detroit vs Boston Red being played?
Venue: Fenway Park.
What are the opening odds for Detroit vs Boston Red?
Spread: Boston Red LOADING
Moneyline: Detroit LOADING, Boston Red LOADING
Over/Under: LOADING
What are the records for Detroit vs Boston Red?
Detroit: (87-74) | Boston Red: (88-73)
What is the AI best bet for Detroit vs Boston Red?
Remi's searched hard and found the best prop for this matchup: W. Abreu under 1.5 Hits+Runs+RBI.. Prices move—always shop for the best number.
What are Detroit vs Boston Red trending bets?
In recent head-to-head matchups at Fenway, betting trends have shown that Boston performs better than average as a home favorite, and that totals tend to lean over 8.5 when Detroit is on the road.
What are Detroit trending bets?
DET trend: The Tigers have struggled against the spread this season, carrying a record near 72–87 ATS entering this matchup.
What are Boston Red trending bets?
BOS trend: The Red Sox have fared better ATS, standing around 81–79 ATS this year.
Where can I find AI Picks for Detroit vs Boston Red?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Detroit vs. Boston Red Odds
AI algorithm Remi is pouring through tons of data on each team. In fact, anytime the Detroit vs Boston Red trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable betting trends.
Detroit vs Boston Red Opening Odds
DET Moneyline:
LOADING BOS Moneyline: LOADING
DET Spread: LOADING
BOS Spread: LOADING
Over/Under: LOADING
Detroit vs Boston Red Live Odds
Games | PTS | ML | SPR | O/U | |
---|---|---|---|---|---|
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
|
–
–
|
+100
-120
|
-1.5 (+175)
+1.5 (-215)
|
O 7 (-105)
U 7 (-115)
|
|
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
|
–
–
|
+100
-118
|
-1.5 (+172)
+1.5 (-210)
|
O 7.5 (-110)
U 7.5 (-110)
|
|
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
|
–
–
|
+136
-162
|
+1.5 (-160)
-1.5 (+130)
|
O 7.5 (-120)
U 7.5 (-102)
|
|
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
|
–
–
|
+110
-130
|
pk
pk
|
|
|
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
|
–
–
|
+108
-126
|
pk
pk
|
O 7 (-135)
U 7 (+115)
|
MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Detroit Tigers vs. Boston Red Sox on September 28, 2025 at Fenway Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |