Tigers vs. Sox
Prediction, Odds & Props
Sep 28 | MLB AI Picks

Updated: 2025-09-26T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Detroit Tigers travel to Fenway Park on September 28, 2025, to face the Boston Red Sox in what may be a pivotal late-season game as both clubs jockey for playoff positioning. Boston, having recently clinched a Wild Card berth, will look to keep momentum and fine-tune pieces, while Detroit, still alive in the postseason chase, needs every win it can get to solidify its spot.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 28, 2025

Start Time: 3:05 PM EST​

Venue: Fenway Park​

Sox Record: (88-73)

Tigers Record: (87-74)

OPENING ODDS

DET Moneyline: LOADING

BOS Moneyline: LOADING

DET Spread: LOADING

BOS Spread: LOADING

Over/Under: LOADING

DET
Betting Trends

  • The Tigers have struggled against the spread this season, carrying a record near 72–87 ATS entering this matchup.

BOS
Betting Trends

  • The Red Sox have fared better ATS, standing around 81–79 ATS this year.

MATCHUP TRENDS

  • In recent head-to-head matchups at Fenway, betting trends have shown that Boston performs better than average as a home favorite, and that totals tend to lean over 8.5 when Detroit is on the road.

DET vs. BOS
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: W. Abreu under 1.5 Hits+Runs+RBI.

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Detroit vs Boston Red Prediction & Odds:
Free MLB Betting Insights for 9/28/25

The upcoming September 26, 2025, showdown between the Detroit Tigers and the Boston Red Sox at Fenway Park promises to be one of the more intriguing late-season battles in Major League Baseball, with Boston having clinched a Wild Card berth and Detroit still fighting to keep their postseason hopes alive. The Tigers come into this matchup knowing that every game is critical; their recent struggles, both offensively and with pitching consistency, have placed them in a precarious position, and their margin for error is razor-thin. They will likely lean heavily on Spencer Torkelson and Riley Greene to spark their lineup, as both have proven capable of carrying Detroit’s offense in stretches, but the larger issue remains whether the rotation can provide a quality start to avoid exposing a bullpen that has faltered in tight contests. Boston, on the other hand, has found its stride at the perfect time, clinching their playoff spot with a dramatic walk-off win just days before this contest, giving the team confidence, swagger, and momentum as they prepare to fine-tune for October. The Red Sox have thrived at Fenway this season, combining timely hitting with a rejuvenated bullpen and strong defensive play to secure their Wild Card berth.

They’ll look to Bryce Harper, Kyle Schwarber, and Alec Bohm to continue their offensive surge, while pitchers like Tanner Houck and Brayan Bello will be tasked with setting the tone early and neutralizing Detroit’s power bats. What makes this game particularly compelling is the contrast in motivation: Boston has secured its postseason spot but will want to sharpen its execution and maintain momentum, while Detroit is playing with its season on the line, desperately needing a win to remain in contention. These contrasting narratives create a high-stakes atmosphere at Fenway, where the crowd will be ready to celebrate Boston’s achievement but Detroit will arrive determined to silence them. The Tigers’ key to victory will be to strike early and apply pressure on Boston’s pitchers, forcing mistakes and trying to turn the game into a slugfest, while Boston will aim to control the tempo, execute clean defense, and let its superior depth shine through in the later innings. With the Red Sox favored, the Tigers will need grit, timely power, and perhaps some Fenway magic of their own to leave Boston with a much-needed win.

Detroit Tigers MLB Preview

The Detroit Tigers enter their September 28, 2025, matchup against the Boston Red Sox with an urgency that reflects their current standing in the American League playoff picture, as every inning of every game feels like a test of their ability to survive in a competitive race that has demanded consistency, resilience, and timely execution from all its participants. For Detroit, this game represents both a challenge and an opportunity: a chance to upset a Boston team that has already secured its postseason berth and is now fine-tuning its roster for October, but also a reminder that the Tigers’ margin for error is minimal. Offensively, the Tigers will once again look to Spencer Torkelson and Riley Greene, the young cornerstones of their lineup, who have shown flashes of brilliance throughout the season with their ability to provide power and drive in runs, but Detroit’s lineup has often been plagued by inconsistency, relying too much on big swings rather than sustained rallies. The supporting cast, including hitters like Kerry Carpenter and Colt Keith, must find ways to contribute, especially against Boston pitching that has been sharp at Fenway Park this season.

On the mound, Detroit faces its greatest test, as their rotation has been inconsistent, forcing manager A.J. Hinch to shuffle starters in hopes of catching the right matchup; the bullpen, meanwhile, has been particularly vulnerable in late innings, often struggling to protect slim leads or keep games close enough for the offense to rally. To win against Boston, Detroit must establish control early, ideally with a strong start from its rotation to buy the lineup time to adjust, because allowing Boston’s lineup multiple scoring opportunities at Fenway almost always spells defeat. The Tigers’ path to victory likely involves generating early offense, playing aggressive on the basepaths, and keeping Boston’s crowd subdued, because letting Fenway energy build has proven costly for visiting teams all season. While Detroit may feel the pressure of their dwindling postseason hopes, that urgency could also fuel them to play with a desperation and edge that Boston, with its playoff spot already secured, might not fully match. Yet the Tigers’ Achilles heel remains their bullpen, and unless it can find ways to hold leads or deliver shutdown innings, even a strong offensive performance could unravel late. Ultimately, this game represents Detroit’s chance to prove that their youth and rebuilding pieces can rise to the moment, but it will require their hitters to attack early, their pitchers to execute with precision, and their defense to remain sharp under pressure. Anything less risks leaving Fenway Park with another costly loss, which could very well put their postseason aspirations out of reach.

The Detroit Tigers travel to Fenway Park on September 28, 2025, to face the Boston Red Sox in what may be a pivotal late-season game as both clubs jockey for playoff positioning. Boston, having recently clinched a Wild Card berth, will look to keep momentum and fine-tune pieces, while Detroit, still alive in the postseason chase, needs every win it can get to solidify its spot. Detroit vs Boston Red AI Prediction: Free MLB Betting Insights for Sep 28. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Boston Red Sox MLB Preview

The Boston Red Sox step into their September 28, 2025, matchup against the Detroit Tigers at Fenway Park with the luxury of playing with confidence, as they’ve already secured a place in the postseason and are now focused on fine-tuning their lineup and rotation for October, a position that reflects the consistency and depth they’ve shown all year. For Boston, this game provides an opportunity to sharpen details, test matchups, and perhaps rest certain regulars while still maintaining their momentum heading into the playoffs. At the heart of their success has been Rafael Devers, who continues to anchor the middle of the lineup with his blend of power and clutch hitting, while Triston Casas and Jarren Duran have provided complementary offense that stretches the lineup and forces opposing pitchers to navigate multiple threats. Boston’s depth has been a hallmark of their 2025 season, as role players like Wilyer Abreu and Ceddanne Rafaela have stepped up in key moments, while veterans such as Trevor Story have contributed both offensively and defensively when healthy. On the pitching side, the Red Sox rotation has held firm thanks to the resurgence of Nick Pivetta and steady performances from young arms who have developed into reliable options throughout the grind of the season, and with the bullpen anchored by closer Kenley Jansen, Boston has found stability in the later innings.

Manager Alex Cora has emphasized situational execution and aggressive baserunning, an approach that has worn down opponents and consistently tilted games in Boston’s favor. Against Detroit, the Red Sox will aim to establish control early, using their patient approach at the plate to drive up pitch counts and exploit the Tigers’ pitching staff, which has struggled at times with command and depth. Fenway Park’s atmosphere will only add to the challenge for Detroit, as the Red Sox faithful have energized their team all season and will be eager to see their club close out the final week of the regular season on a strong note. Still, while Boston holds the edge on paper, the focus for Cora and his staff will be balancing the need to win with the necessity of keeping players healthy and managing workloads ahead of the playoffs. That balance may open the door for Detroit to hang around if the Red Sox experiment with lineup rotations or bullpen usage, but Boston’s depth gives them enough firepower to handle such adjustments without significantly lowering their odds of victory. In many ways, this game will serve as a postseason tune-up, a chance to keep rhythm while still experimenting with matchups, and if Boston continues to execute with the precision and energy they’ve shown for much of 2025, they should be well-positioned not only to dispatch Detroit but to carry momentum into October with confidence that they are battle-tested and ready for the challenges ahead.

Detroit vs. Boston Red Prop Picks (AI)

Remi is pouring through loads of datapoints on each player. In fact, anytime the Tigers and Sox play there’s always several intriguing trends to key in on. Not to mention games played at Fenway Park in Sep can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: W. Abreu under 1.5 Hits+Runs+RBI.

Detroit vs. Boston Red Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over mountains of data from every simulation between the Tigers and Sox and using recursive machine learning and impressive AI to crunch the data to a single cover probability.

Remi has been most fixated on the trending emphasis knucklehead sportsbettors tend to put on Boston Red’s strength factors between a Tigers team going up against a possibly improved Sox team. In reality, the true game analytics appear to reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Detroit vs Boston Red picks, computer picks Tigers vs Sox, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 BOS@NYY UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 CIN@LAD GET FREE PICK NOW 1
MLB 10/1 BOS@NYY UNLOCK THIS PICK 0 INTEL Locked INTEL
MLB 10/1 BOS@NYY GET FREE PICK NOW 0

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Tigers Betting Trends

The Tigers have struggled against the spread this season, carrying a record near 72–87 ATS entering this matchup.

Sox Betting Trends

The Red Sox have fared better ATS, standing around 81–79 ATS this year.

Tigers vs. Sox Matchup Trends

In recent head-to-head matchups at Fenway, betting trends have shown that Boston performs better than average as a home favorite, and that totals tend to lean over 8.5 when Detroit is on the road.

Detroit vs. Boston Red Game Info

Detroit vs Boston Red starts on September 28, 2025 at 3:05 PM EST.

Spread: Boston Red LOADING
Moneyline: Detroit LOADING, Boston Red LOADING
Over/Under: LOADING

Detroit: (87-74)  |  Boston Red: (88-73)

Remi's searched hard and found the best prop for this matchup: W. Abreu under 1.5 Hits+Runs+RBI.. Prices move—always shop for the best number.

In recent head-to-head matchups at Fenway, betting trends have shown that Boston performs better than average as a home favorite, and that totals tend to lean over 8.5 when Detroit is on the road.

DET trend: The Tigers have struggled against the spread this season, carrying a record near 72–87 ATS entering this matchup.

BOS trend: The Red Sox have fared better ATS, standing around 81–79 ATS this year.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Detroit vs. Boston Red Odds

AI algorithm Remi is pouring through tons of data on each team. In fact, anytime the Detroit vs Boston Red trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable betting trends.

Detroit vs Boston Red Opening Odds

DET Moneyline: LOADING
BOS Moneyline: LOADING
DET Spread: LOADING
BOS Spread: LOADING
Over/Under: LOADING

Detroit vs Boston Red Live Odds

Games PTS ML SPR O/U
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
+100
-120
-1.5 (+175)
+1.5 (-215)
O 7 (-105)
U 7 (-115)
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
+100
-118
-1.5 (+172)
+1.5 (-210)
O 7.5 (-110)
U 7.5 (-110)
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
+136
-162
+1.5 (-160)
-1.5 (+130)
O 7.5 (-120)
U 7.5 (-102)
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
+110
-130
pk
pk
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
+108
-126
pk
pk
O 7 (-135)
U 7 (+115)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Detroit Tigers vs. Boston Red Sox on September 28, 2025 at Fenway Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS