Reds vs. Brewers
Prediction, Odds & Props
Sep 28 | MLB AI Picks

Updated: 2025-09-26T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Cincinnati Reds travel to Milwaukee on September 28, 2025, to face the Brewers in what could be a pivotal contest for postseason positioning and pride. The Brewers are fighting to maintain momentum and home dominance, while the Reds are battling for every inch in the wild card chase.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 28, 2025

Start Time: 3:10 PM EST​

Venue: American Family Field​

Brewers Record: (96-65)

Reds Record: (83-78)

OPENING ODDS

CIN Moneyline: LOADING

MIL Moneyline: LOADING

CIN Spread: LOADING

MIL Spread: LOADING

Over/Under: LOADING

CIN
Betting Trends

  • The Reds have covered in 6 of their past 10 road games, leaning on strong pitching performances and opportunistic hitting.

MIL
Betting Trends

  • The Brewers have been more dominant at home, covering in 7 of their last 10 games at American Family Field, buoyed by strong offense and crowd support.

MATCHUP TRENDS

  • Milwaukee holds a 7–3 edge over Cincinnati this season in head-to-head matchups. Also, the under has cashed frequently in recent meetings, as these teams often slug it out in tight, low-scoring affairs.

CIN vs. MIL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: F. Peralta over 22.5 Fantasy Score.

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Cincinnati vs Milwaukee Prediction & Odds:
Free MLB Betting Insights for 9/28/25

The Cincinnati Reds head into one of their most consequential road games of the season when they visit the Milwaukee Brewers on September 28, 2025 — a game that represents more than just another regular season meeting. For Cincinnati, this game is part of a final push in what has been a hard-fought wild-card race, and every swing, every pitch, and every defensive play carries amplified importance. The Reds’ season has been defined by moments of resilience and flashes of youthful promise: Elly De La Cruz continues to be one of the most exciting young talents in the league, blending speed, defense, and occasional hitting to keep opposing teams honest. Vinnie Pasquantino and Spencer Steer provide balance in the batting order with a blend of patience and gap power, while Tyler Stephenson’s hot streaks and positional flexibility have given manager Terry Francona more options. On the mound, Cincinnati will likely lean on starter Brady Singer, whose seasonal record has been respectable and his strikeout ability gives the Reds a chance to quiet Milwaukee’s power bats. However, the supporting arms and bullpen are areas of concern — late-inning durability has not always been there, and against a strong Brewers offense, that can be dangerous.

Defensively, Cincinnati has improved in 2025, but lapses in execution still pop up at inopportune times. On the Brewers’ side, they’re entering this game riding both momentum and expectation. Milwaukee is one of the top teams in the National League this year, backing that success with a potent lineup, balanced offense, and a pitching staff that has shown both depth and dominance. Christian Yelich, Brice Turang, and Jackson Chourio provide a varied mix of power, speed, and contact ability, making Milwaukee’s offense a multi-headed threat. Their starting rotation, anchored by Freddy Peralta, brings veteran poise, and their bullpen is among the more dependable in the league — an important advantage late in games. The Brewers also enjoy one of the more intimidating home crowds and a ballpark environment they know intimately. Tactically, this series finale will hinge on matchups. Cincinnati will need to manufacture runs, perhaps with small ball, aggressive baserunning, and getting crafty against Milwaukee’s starter and bullpen arms. For Milwaukee, the aim will be to leverage offensive depth and capitalize on mistakes — making sure gaps are punished and momentum stays shifted in their favor. Given the stakes, expect both teams to dig deep — for the Reds, it’s a chance to stay alive in the wild card; for the Brewers, it’s a chance to assert dominance and close the regular season strong.

Cincinnati Reds MLB Preview

The Cincinnati Reds head into their September 28 clash with the Milwaukee Brewers knowing that the margin for error is razor-thin as the regular season winds down and the playoff picture begins to sharpen. For the Reds, this game is not just another matchup but a litmus test of how far their young core has come and whether they can handle the pressure of meaningful baseball in late September. Elly De La Cruz has been the lightning rod for Cincinnati all year, dazzling with his speed, defensive range, and ability to alter games with a single swing or sprint, but he will need to balance his aggressive approach with patience against Milwaukee’s seasoned arms. Supporting him, Spencer Steer and Vinnie Pasquantino have emerged as steady presences in the middle of the lineup, providing the kind of balance and run-producing ability that keeps pitchers from pitching around the Reds’ top threats. Tyler Stephenson has also been a critical piece, giving the Reds stability behind the plate and timely production in clutch situations, while the Reds’ role players and bench depth will be tested in a high-pressure environment where every at-bat matters.

On the mound, Cincinnati is expected to send Brady Singer to the hill, and his ability to generate swings and misses and keep the ball on the ground will be paramount against a Brewers team that thrives on contact hitting and manufacturing momentum. The Reds’ rotation has been serviceable, but their bullpen remains the biggest question mark, as inconsistency late in games has cost them dearly throughout the season, and against a team like Milwaukee that thrives in late-inning situations, the importance of strong relief pitching cannot be overstated. Defensively, Cincinnati has made strides, with De La Cruz anchoring the infield and outfielders tightening up their reads and execution, but lapses still occasionally surface and cannot be afforded in a game of this magnitude. Strategically, the Reds will likely need to be creative, relying on aggressive baserunning, smart situational hitting, and perhaps some small-ball tactics to generate offense against Milwaukee’s strong pitching staff. They cannot afford to get into a slugfest but instead must aim to keep the game close, capitalize on any mistakes, and pressure the Brewers into uncomfortable situations. As the road team, they will be tasked with quieting a raucous crowd at American Family Field, a place where Milwaukee has excelled all season, and the Reds’ ability to remain poised in hostile territory will be as important as anything they do between the lines. For Cincinnati, the stakes are simple: execute well, stay disciplined, and seize the opportunities when they arise, because a win here would not only boost their playoff hopes but also send a message that their young group is ready to compete with the league’s best.

The Cincinnati Reds travel to Milwaukee on September 28, 2025, to face the Brewers in what could be a pivotal contest for postseason positioning and pride. The Brewers are fighting to maintain momentum and home dominance, while the Reds are battling for every inch in the wild card chase. Cincinnati vs Milwaukee AI Prediction: Free MLB Betting Insights for Sep 28. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Milwaukee Brewers MLB Preview

The Milwaukee Brewers enter their September 28 matchup against the Cincinnati Reds with the comfort of playing at American Family Field, where they have consistently leaned on strong pitching, timely hitting, and the energy of a supportive home crowd to stay in the thick of the playoff race. This game is critical for Milwaukee not only because of its postseason implications but also because the Reds are a divisional rival who have made life difficult all season, and the Brewers understand that winning head-to-head battles like this could be the difference between a division crown and a wild-card spot. At the plate, Milwaukee has leaned heavily on the production of Christian Yelich, who has rediscovered stretches of his All-Star form with his mix of power and patience, and William Contreras, who has been one of the most consistent offensive threats in their lineup while providing leadership behind the plate. The Brewers’ offense has also benefited from young contributors like Brice Turang and Sal Frelick, whose speed and ability to create havoc on the bases give them an added layer of versatility, while veteran bats such as Rhys Hoskins and Willy Adames offer the kind of power and run production necessary to seize momentum in key moments.

Pitching, however, remains Milwaukee’s greatest strength, and their expected starter, Freddy Peralta, will be counted on to set the tone by attacking the Reds’ lineup with his strikeout stuff while minimizing mistakes that could lead to crooked numbers. The Brewers’ bullpen, long regarded as one of the best in the league, remains a crucial weapon, especially with closer Devin Williams anchoring the late innings, and Milwaukee’s ability to shorten games through dominant relief pitching has been a hallmark of their success. On defense, the Brewers are sound, with Adames providing stability at shortstop and the outfielders excelling at cutting off gaps, while Contreras has done well controlling the running game—an especially important factor against Cincinnati’s aggressive baserunners. Strategically, Milwaukee will look to wear down Cincinnati’s pitching staff with disciplined at-bats, forcing starters into high pitch counts and putting pressure on a Reds bullpen that has shown cracks in late-game execution. They also have the luxury of playing at home, where the ballpark dimensions reward their gap-to-gap hitting approach and where they have built an identity around protecting their turf and thriving in front of their fans. This game, while just one on the schedule, carries postseason weight, and the Brewers understand that a strong performance will not only reinforce their standing but also deal a blow to the Reds’ momentum. Ultimately, Milwaukee’s formula for victory remains clear: ride their pitching, capitalize on scoring chances with situational hitting, and rely on the consistency of their veteran leaders to navigate the pressure of a high-stakes divisional showdown. If they execute, they will remind the rest of the National League that they remain one of the toughest teams to beat when the lights are brightest and the games matter most.

Cincinnati vs. Milwaukee Prop Picks (AI)

AI algorithm Remi is pouring through tons of datapoints on each team. In fact, anytime the Reds and Brewers play there’s always several intriguing observations to key in on. Not to mention games played at American Family Field in Sep can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: F. Peralta over 22.5 Fantasy Score.

Cincinnati vs. Milwaukee Prediction (AI)

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Remi, our AI sports genius, has been pouring over millions of data from every simulation between the Reds and Brewers and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.

The Algorithm has been most watching on the linear correlation of emphasis knucklehead sportsbettors tend to put on player performance factors between a Reds team going up against a possibly deflated Brewers team. In reality, the true game analytics might reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Cincinnati vs Milwaukee picks, computer picks Reds vs Brewers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 BOS@NYY UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 CIN@LAD GET FREE PICK NOW 1
MLB 10/1 BOS@NYY UNLOCK THIS PICK 0 INTEL Locked INTEL
MLB 10/1 BOS@NYY GET FREE PICK NOW 0

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Reds Betting Trends

The Reds have covered in 6 of their past 10 road games, leaning on strong pitching performances and opportunistic hitting.

Brewers Betting Trends

The Brewers have been more dominant at home, covering in 7 of their last 10 games at American Family Field, buoyed by strong offense and crowd support.

Reds vs. Brewers Matchup Trends

Milwaukee holds a 7–3 edge over Cincinnati this season in head-to-head matchups. Also, the under has cashed frequently in recent meetings, as these teams often slug it out in tight, low-scoring affairs.

Cincinnati vs. Milwaukee Game Info

Cincinnati vs Milwaukee starts on September 28, 2025 at 3:10 PM EST.

Venue: American Family Field.

Spread: Milwaukee LOADING
Moneyline: Cincinnati LOADING, Milwaukee LOADING
Over/Under: LOADING

Cincinnati: (83-78)  |  Milwaukee: (96-65)

Remi's searched hard and found the best prop for this matchup: F. Peralta over 22.5 Fantasy Score.. Prices move—always shop for the best number.

Milwaukee holds a 7–3 edge over Cincinnati this season in head-to-head matchups. Also, the under has cashed frequently in recent meetings, as these teams often slug it out in tight, low-scoring affairs.

CIN trend: The Reds have covered in 6 of their past 10 road games, leaning on strong pitching performances and opportunistic hitting.

MIL trend: The Brewers have been more dominant at home, covering in 7 of their last 10 games at American Family Field, buoyed by strong offense and crowd support.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Cincinnati vs. Milwaukee Odds

AI algorithm Remi is pouring through tons of stats on each team. In fact, anytime the Cincinnati vs Milwaukee trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable patterns.

Cincinnati vs Milwaukee Opening Odds

CIN Moneyline: LOADING
MIL Moneyline: LOADING
CIN Spread: LOADING
MIL Spread: LOADING
Over/Under: LOADING

Cincinnati vs Milwaukee Live Odds

Games PTS ML SPR O/U
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
+100
-120
-1.5 (+175)
+1.5 (-215)
O 7 (-105)
U 7 (-115)
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
+100
-118
-1.5 (+172)
+1.5 (-210)
O 7.5 (-110)
U 7.5 (-110)
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
+136
-162
+1.5 (-160)
-1.5 (+130)
O 7.5 (-120)
U 7.5 (-102)
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
+110
-130
pk
pk
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
+108
-126
pk
pk
O 7 (-135)
U 7 (+115)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Cincinnati Reds vs. Milwaukee Brewers on September 28, 2025 at American Family Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS