Orioles vs. Yankees
Prediction, Odds & Props
Sep 28 | MLB AI Picks

Updated: 2025-09-26T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Baltimore Orioles and New York Yankees square off on September 28, 2025, in a pivotal late-season clash with postseason implications hanging in the balance. Both teams have been fighting for positioning in the AL East and Wild Card race, making this matchup at Yankee Stadium one of the weekend’s most high-stakes contests.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 28, 2025

Start Time: 3:05 PM EST​

Venue: Yankee Stadium​

Yankees Record: (93-68)

Orioles Record: (75-86)

OPENING ODDS

BAL Moneyline: LOADING

NYY Moneyline: LOADING

BAL Spread: LOADING

NYY Spread: LOADING

Over/Under: LOADING

BAL
Betting Trends

  • The Orioles have struggled recently against the spread, particularly on the road, where they’ve covered in just three of their last ten games.

NYY
Betting Trends

  • The Yankees have been more reliable at home, covering in six of their last ten at Yankee Stadium while riding solid pitching performances.

MATCHUP TRENDS

  • The Orioles have gone under the total in seven of their last ten games, while the Yankees have leaned toward overs in five of their last eight, making this a tricky betting angle where bullpen usage and late-inning offense could tilt the totals.

BAL vs. NYY
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: K. Bradish over 20.5 Fantasy Score.

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Baltimore vs New York Prediction & Odds:
Free MLB Betting Insights for 9/28/25

The Orioles and Yankees meeting on September 28, 2025, at Yankee Stadium carries all the drama and weight of a playoff showdown, with both teams fighting for leverage in the postseason picture and the AL East rivalry fueling the atmosphere. The Orioles enter the contest leaning on their young core, which has carried them through a season of ups and downs, while the Yankees remain firmly in the spotlight as perennial contenders led by their star-laden roster. Baltimore’s season has revolved around the growth of Adley Rutschman, Gunnar Henderson, and Jackson Holliday, a trio that has given the Orioles a balanced attack of power, speed, and defensive consistency. Rutschman’s leadership behind the plate has been crucial in handling an evolving pitching staff, while Henderson’s ability to hit for both power and average has kept the lineup dangerous in the middle. Holliday’s youthful energy has brought an element of unpredictability, making him a threat on the bases and a spark plug for rallies. However, Baltimore’s pitching has been tested over the grind of the season, with Grayson Rodriguez stepping into the role of staff ace but the bullpen showing some cracks, forcing Félix Bautista to shoulder an even heavier workload down the stretch. The Yankees, by contrast, have built their success around the sheer dominance of Aaron Judge and Juan Soto, who together form one of the most feared offensive tandems in the sport. Judge’s power numbers remain jaw-dropping, but his ability to come through in clutch spots is just as impactful, while Soto’s disciplined approach forces pitchers into difficult decisions that often result in mistakes.

Surrounding them is a cast of supporting hitters like Anthony Volpe, Gleyber Torres, and Giancarlo Stanton, who add depth and allow the Yankees to pressure opposing pitchers from top to bottom of the lineup. Gerrit Cole once again anchors the rotation, giving New York a true ace who thrives in big games, while their bullpen, with Clay Holmes leading the way, has been reliable enough to secure late-inning leads. Strategically, the Yankees will likely lean on their patience at the plate to wear down Baltimore’s young arms, forcing deep counts and waiting for mistakes, while Baltimore must counter with timely hitting and an aggressive approach on the bases to keep pressure on the Yankees’ defense. Yankee Stadium’s dimensions also shape this matchup, as the short porch in right field could come into play for both sides, with Judge and Soto eyeing the seats while left-handed Orioles bats look to exploit the same advantage. Both teams understand the stakes, with Baltimore trying to prove that its rebuild has fully matured into a contender and New York aiming to remind the league that October runs through the Bronx. What makes this matchup especially intriguing is that each team’s strengths seem to counter the other’s: Baltimore’s speed and youth challenge New York’s power and experience, and the team that better executes in situational hitting and bullpen management will likely emerge victorious. With the postseason looming, this game may serve as both a preview of October intensity and a defining moment in each team’s 2025 campaign.

Baltimore Orioles MLB Preview

The Baltimore Orioles head into Yankee Stadium on September 28, 2025, with the goal of showing that their young roster can thrive under the spotlight and compete with one of the league’s most storied franchises when the stakes are high. For Baltimore, this game represents more than just another contest in the standings—it is a chance to prove their rebuild has blossomed into sustained contention, driven by the development of homegrown talent that has energized their fan base and reshaped the American League East. Leading the way is Adley Rutschman, the catcher whose combination of leadership, plate discipline, and defensive command has anchored both the lineup and pitching staff throughout the year. Gunnar Henderson has also stepped into a starring role, flashing elite power and range in the infield, while top prospect Jackson Holliday has injected youthful energy with his speed and bat-to-ball skills, making him a dangerous weapon near the top of the order. On the pitching side, Grayson Rodriguez has become Baltimore’s ace-in-the-making, learning to attack hitters with a combination of high-velocity fastballs and refined secondary pitches, while the bullpen has leaned heavily on Félix Bautista to close games despite the wear and tear of a long season.

The Orioles’ path to victory against the Yankees will likely depend on their ability to capitalize on scoring opportunities early, forcing Gerrit Cole and the New York staff into stressful innings rather than allowing them to settle into a rhythm. Offensively, Baltimore will need contributions beyond their stars, with hitters like Anthony Santander and Ryan Mountcastle providing key depth in the middle of the lineup, giving them the power to take advantage of Yankee Stadium’s hitter-friendly right-field dimensions. Defensively, Baltimore’s athleticism and strong arms in the outfield, particularly from Austin Hays and Cedric Mullins, will be critical in limiting New York’s extra-base potential and preventing extended rallies. Manager Brandon Hyde has also emphasized aggressive baserunning, something that could prove decisive if the Orioles push the Yankees’ defense to execute under pressure. Still, the Orioles enter as underdogs, and much of their ability to keep the game competitive will rest on avoiding mistakes, maintaining bullpen efficiency, and delivering in clutch situations where the Yankees have historically thrived. A win here would be more than just another tally in the standings; it would symbolize Baltimore’s ability to go toe-to-toe with an established powerhouse on the road in one of baseball’s toughest environments, setting the stage for a franchise eager to establish itself not just as a playoff hopeful but as a legitimate postseason threat.

The Baltimore Orioles and New York Yankees square off on September 28, 2025, in a pivotal late-season clash with postseason implications hanging in the balance. Both teams have been fighting for positioning in the AL East and Wild Card race, making this matchup at Yankee Stadium one of the weekend’s most high-stakes contests. Baltimore vs New York AI Prediction: Free MLB Betting Insights for Sep 28. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

New York Yankees MLB Preview

The New York Yankees welcome the Baltimore Orioles to Yankee Stadium on September 28, 2025, with all eyes on how they will continue to flex their dominance in one of the most heated rivalries in the American League. The Yankees have spent much of the season building around their potent lineup anchored by Aaron Judge and Juan Soto, a duo that has terrorized opposing pitchers with their combination of power and plate discipline, making New York one of the most dangerous offenses in baseball. Judge’s ability to change a game with one swing is well-documented, but it is his knack for delivering in big moments that makes him invaluable, while Soto’s ability to grind at-bats and draw walks has kept pitchers constantly on the defensive. Surrounding them is a supporting cast of Anthony Volpe, Gleyber Torres, and Giancarlo Stanton, all of whom add depth and ensure that pitchers cannot take a breather anywhere in the order. On the pitching side, Gerrit Cole remains the ace, and with the postseason looming, the Yankees are likely to lean heavily on him to set the tone in a contest of this magnitude, while the bullpen, led by Clay Holmes and a host of reliable arms, has provided enough stability to hold late-inning leads.

Strategically, manager Aaron Boone will look to control the tempo early by forcing Baltimore’s young arms into deep counts, wearing down their bullpen, and exploiting any lack of experience in high-pressure situations. Yankee Stadium’s short porch in right field will also play to New York’s strengths, particularly with their left-handed bats and Judge’s power stroke, making it difficult for Baltimore to navigate the lineup without damage. Beyond the X’s and O’s, the Yankees carry the weight of tradition and expectation, with fans demanding both victories and statement performances against rivals like the Orioles, especially as playoff positioning becomes critical. What makes this matchup particularly important for New York is not just the chance to secure another win but to remind Baltimore that, despite their rise, the path to American League dominance still runs through the Bronx. With a combination of veteran leadership, postseason experience, and a fan base that thrives on creating an electric home-field atmosphere, the Yankees will look to impose their will from the first pitch. If they can get an early lead and let their bullpen lock down the late innings, New York will be well-positioned to showcase why they remain one of baseball’s elite teams, while also sending a clear message that their sights are firmly set on October glory.

Baltimore vs. New York Prop Picks (AI)

AI algorithm Remi is pouring through loads of datapoints on each team. In fact, anytime the Orioles and Yankees play there’s always several intriguing angles to key in on. Not to mention games played at Yankee Stadium in Sep can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: K. Bradish over 20.5 Fantasy Score.

Baltimore vs. New York Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over millions of data from every angle between the Orioles and Yankees and using recursive machine learning and impressive AI to analyze the data to a single cover probability.

Interestingly enough, the data has been most fixated on the linear correlation of emphasis emotional bettors often put on player performance factors between a Orioles team going up against a possibly rested Yankees team. It appears the true game analytics appear to reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Baltimore vs New York picks, computer picks Orioles vs Yankees, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 BOS@NYY UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 CIN@LAD GET FREE PICK NOW 1
MLB 10/1 BOS@NYY UNLOCK THIS PICK 0 INTEL Locked INTEL
MLB 10/1 BOS@NYY GET FREE PICK NOW 0

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Orioles Betting Trends

The Orioles have struggled recently against the spread, particularly on the road, where they’ve covered in just three of their last ten games.

Yankees Betting Trends

The Yankees have been more reliable at home, covering in six of their last ten at Yankee Stadium while riding solid pitching performances.

Orioles vs. Yankees Matchup Trends

The Orioles have gone under the total in seven of their last ten games, while the Yankees have leaned toward overs in five of their last eight, making this a tricky betting angle where bullpen usage and late-inning offense could tilt the totals.

Baltimore vs. New York Game Info

Baltimore vs New York starts on September 28, 2025 at 3:05 PM EST.

Spread: New York LOADING
Moneyline: Baltimore LOADING, New York LOADING
Over/Under: LOADING

Baltimore: (75-86)  |  New York: (93-68)

Remi's searched hard and found the best prop for this matchup: K. Bradish over 20.5 Fantasy Score.. Prices move—always shop for the best number.

The Orioles have gone under the total in seven of their last ten games, while the Yankees have leaned toward overs in five of their last eight, making this a tricky betting angle where bullpen usage and late-inning offense could tilt the totals.

BAL trend: The Orioles have struggled recently against the spread, particularly on the road, where they’ve covered in just three of their last ten games.

NYY trend: The Yankees have been more reliable at home, covering in six of their last ten at Yankee Stadium while riding solid pitching performances.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Baltimore vs. New York Odds

Remi is pouring through tons of data on each line. In fact, anytime the Baltimore vs New York trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps can often follow normal, predictable betting trends.

Baltimore vs New York Opening Odds

BAL Moneyline: LOADING
NYY Moneyline: LOADING
BAL Spread: LOADING
NYY Spread: LOADING
Over/Under: LOADING

Baltimore vs New York Live Odds

Games PTS ML SPR O/U
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
+100
-120
-1.5 (+175)
+1.5 (-215)
O 7 (-105)
U 7 (-115)
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
+100
-118
-1.5 (+172)
+1.5 (-210)
O 7.5 (-110)
U 7.5 (-110)
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
+136
-162
+1.5 (-160)
-1.5 (+130)
O 7.5 (-120)
U 7.5 (-102)
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
+110
-130
pk
pk
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
+108
-126
pk
pk
O 7 (-135)
U 7 (+115)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Baltimore Orioles vs. New York Yankees on September 28, 2025 at Yankee Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS