Diamondbacks vs. Padres
Prediction, Odds & Props
Sep 28 | MLB AI Picks

Updated: 2025-09-26T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Arizona Diamondbacks and San Diego Padres square off on September 28, 2025, in a late-season NL West showdown where both teams look to close strong and maintain divisional pride. With Arizona relying on its dynamic young core and San Diego leaning on its superstar-heavy roster, this matchup promises plenty of intensity.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 28, 2025

Start Time: 3:10 PM EST​

Venue: Petco Park​

Padres Record: (89-72)

Diamondbacks Record: (80-81)

OPENING ODDS

ARI Moneyline: LOADING

SD Moneyline: LOADING

ARI Spread: LOADING

SD Spread: LOADING

Over/Under: LOADING

ARI
Betting Trends

  • The Diamondbacks have struggled on the road against division rivals, covering inconsistently despite flashes of offensive production.

SD
Betting Trends

  • The Padres have fared better at home, often covering spreads when their pitching holds steady and their lineup provides run support.

MATCHUP TRENDS

  • Meetings between these clubs often trend toward high scoring, with the over hitting more often than not due to both teams’ offensive capabilities. However, close margins have been a theme, with many recent games decided by three runs or fewer.

ARI vs. SD
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: F. Tatis over 6.5 Fantasy Score.

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Arizona vs San Diego Prediction & Odds:
Free MLB Betting Insights for 9/28/25

The matchup between the Arizona Diamondbacks and the San Diego Padres on September 28, 2025, brings together two teams with very different paths but similar stakes as they battle for relevance and positioning in the fiercely competitive NL West, and it promises to be one of the more intriguing late-season clashes of the year. The Padres enter the contest with their reputation as one of baseball’s most star-studded rosters, featuring the likes of Fernando Tatis Jr., Manny Machado, Xander Bogaerts, and Juan Soto, players whose names alone strike fear into opposing pitchers and who collectively bring a blend of power, patience, and flair that makes San Diego dangerous every time they take the field. Built on big investments and high expectations, the Padres know they are measured by their ability to win these types of late-season games, particularly at Petco Park where their fans demand results. On the other side, the Diamondbacks bring the scrappy, energetic identity of a team on the rise, defined by young talent like Corbin Carroll, who has quickly established himself as one of the most exciting players in baseball, paired with the steady leadership of Ketel Marte and the power presence of Christian Walker. Arizona’s style is less about overwhelming opponents with sheer force and more about leveraging speed, athleticism, and situational hitting to create chaos on the basepaths and keep pressure on defenses, while Zac Gallen’s status as a frontline ace provides them with the type of arm capable of silencing even elite lineups like San Diego’s.

What makes this contest especially compelling is the clash of philosophies: the Padres leaning on star power and experience to outslug and outlast their opponents, while the Diamondbacks aim to turn every at-bat, stolen base, and defensive play into a potential game-changer. Both teams come into the game with postseason implications hovering over their heads, whether it’s San Diego trying to lock in playoff seeding and show they can dominate division rivals, or Arizona aiming to play spoiler and prove their young core is ready for the spotlight. The pitching matchup could be decisive, as the Padres’ veteran rotation led by Yu Darvish and Joe Musgrove is tasked with containing Carroll’s disruptive speed and Arizona’s ability to nickel-and-dime runs, while Gallen or Merrill Kelly will need to hold down a Padres lineup that punishes mistakes. Defensively, San Diego has the edge in infield experience and steady gloves, while Arizona counters with rangy outfielders who can take away extra bases, a crucial factor in keeping San Diego’s sluggers in check. The bullpens for both sides also loom large, with San Diego’s ability to shorten games a major weapon but Arizona’s pen often proving capable in clutch moments despite some inconsistency. Ultimately, this game represents more than just one win or loss—it symbolizes where these franchises are headed, with the Padres trying to validate their star-laden roster with tangible results and the Diamondbacks showing that their foundation of speed, youth, and pitching can compete against the best. Fans should expect a tense, playoff-like atmosphere where every pitch matters, every defensive play could shift momentum, and whichever team executes in the late innings will likely walk away with a statement win that echoes beyond the box score.

Arizona Diamondbacks MLB Preview

The Arizona Diamondbacks come into their September 28, 2025, matchup against the San Diego Padres looking to showcase the growth of their young roster and prove that their style of play can translate into success against one of the National League’s most star-studded clubs, and while their season has had its share of ups and downs, Arizona has shown resilience and flashes of real potential that make them a dangerous opponent at this stage of the year. Leading the charge is Corbin Carroll, whose speed, defensive range, and knack for delivering in big moments have made him the face of the franchise and a constant disruptor in every game he plays, whether it’s stealing bases, tracking down balls in the gap, or sparking rallies with extra-base hits. Alongside him, Ketel Marte remains a steady veteran presence, combining versatility with clutch hitting, while Christian Walker continues to serve as a reliable source of power in the middle of the order, often delivering the run production necessary to keep Arizona in games against elite pitching staffs. The Diamondbacks’ lineup also benefits from emerging role players who contribute with situational hitting and defensive flexibility, giving manager Torey Lovullo options to mix and match depending on matchups, a style that has helped Arizona manufacture wins against stronger opponents. On the pitching side, Zac Gallen stands as the ace and workhorse, capable of shutting down even the toughest lineups, while Merrill Kelly provides valuable depth and consistency behind him, though the bullpen remains an area of volatility, with late-inning performance often dictating whether Arizona can secure close victories or see leads slip away.

Defensively, the Diamondbacks pride themselves on athleticism and range, particularly in the outfield, where Carroll and his teammates cut off doubles and neutralize extra-base threats, while Marte’s versatility allows them to plug holes in the infield. What sets Arizona apart is its ability to play a brand of baseball that emphasizes aggressiveness, from taking the extra base to pressuring opponents with stolen bases and small-ball execution, often forcing mistakes from more established clubs. Against the Padres, the Diamondbacks know the margin for error will be thin, and their path to success lies in keeping games close, leaning on Gallen or Kelly to deliver quality starts, and then hoping their bats can break through with timely hits against San Diego’s deep bullpen. The Diamondbacks also thrive when they can seize momentum early, as playing from behind against a lineup packed with sluggers like Fernando Tatis Jr. and Juan Soto forces them out of their comfort zone and into a power-hitting contest they’re not built to win. For Arizona, this game represents more than just a divisional clash; it is a chance to prove that their rebuild is yielding results, that their young stars are capable of performing under pressure, and that they can match up with one of the league’s most hyped and expensive rosters. A road win at Petco Park would not only boost their confidence but also send a message to the rest of the league that the Diamondbacks are no longer a team of the future—they’re ready to compete right now.

The Arizona Diamondbacks and San Diego Padres square off on September 28, 2025, in a late-season NL West showdown where both teams look to close strong and maintain divisional pride. With Arizona relying on its dynamic young core and San Diego leaning on its superstar-heavy roster, this matchup promises plenty of intensity. Arizona vs San Diego AI Prediction: Free MLB Betting Insights for Sep 28. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Diego Padres MLB Preview

The San Diego Padres take the field at Petco Park on September 28, 2025, against the Arizona Diamondbacks with the weight of expectation on their shoulders, as they continue to be one of the most talent-rich teams in baseball and a club built to deliver results in games exactly like this, where late-season momentum and divisional pride are at stake. Their lineup remains a showcase of star power, with Fernando Tatis Jr. bringing athleticism, power, and flair at the top, while Manny Machado provides veteran leadership and clutch production in the middle of the order, and Xander Bogaerts and Juan Soto round out a heart of the lineup that is capable of changing games with a single swing. Complemented by role players such as Ha-Seong Kim and Jake Cronenworth, who add defensive versatility and steady offensive contributions, the Padres boast the type of balance and depth that makes opposing pitchers earn every out. On the mound, San Diego continues to lean on veterans like Yu Darvish and Joe Musgrove, whose ability to deliver quality starts has been pivotal in stabilizing the rotation, while a younger crop of pitchers has stepped up to fill innings and contribute to the team’s long-term sustainability. Their bullpen remains a critical weapon, with power arms capable of dominating in the late innings and shortening games, a luxury that few teams can consistently rely on.

Defensively, the Padres excel in both fundamentals and athleticism, with Machado’s glove at third, Bogaerts’ sure-handed play at short, and Tatis providing highlight-reel plays in the outfield, all of which give their pitchers confidence to attack hitters aggressively. At home, Petco Park has become a fortress, with one of the most passionate fan bases in baseball creating an electric environment that often fuels late rallies and energizes the team through high-pressure moments. Against the Diamondbacks, the Padres know they’ll need to neutralize Corbin Carroll’s speed and Arizona’s penchant for manufacturing runs, and that means controlling the running game while pounding the strike zone early to avoid extended at-bats that wear down their staff. Offensively, San Diego will look to strike first and force the Diamondbacks into chase mode, as Arizona is least comfortable playing from behind against elite opponents, and if Soto and Tatis can set the tone with power while Bogaerts and Machado provide consistency, the Padres can quickly tilt the game in their favor. More than anything, this game is about proving that their roster construction, built on some of the biggest contracts and boldest moves in baseball, can translate into on-field dominance when it matters most. A strong showing at home not only boosts San Diego’s positioning in the division but also reinforces the idea that the Padres are one of the National League’s most formidable postseason threats, capable of overpowering opponents with both star power and execution. For the fans and the franchise alike, this matchup against Arizona is an opportunity to send a message: the Padres are here not just to compete but to prove they belong in the conversation for championships every year.

Arizona vs. San Diego Prop Picks (AI)

AI algorithm Remi is pouring through tons of datapoints on each team. In fact, anytime the Diamondbacks and Padres play there’s always several intriguing trends to key in on. Not to mention games played at Petco Park in Sep rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: F. Tatis over 6.5 Fantasy Score.

Arizona vs. San Diego Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every past game between the Diamondbacks and Padres and using recursive machine learning and industry leading AI to analyze the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most fixated on the unproportionally assigned weight emotional bettors regularly put on coaching factors between a Diamondbacks team going up against a possibly strong Padres team. We’ve found the true game analytics might reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Arizona vs San Diego picks, computer picks Diamondbacks vs Padres, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 BOS@NYY UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 CIN@LAD GET FREE PICK NOW 1
MLB 10/1 BOS@NYY UNLOCK THIS PICK 0 INTEL Locked INTEL
MLB 10/1 BOS@NYY GET FREE PICK NOW 0

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Diamondbacks Betting Trends

The Diamondbacks have struggled on the road against division rivals, covering inconsistently despite flashes of offensive production.

Padres Betting Trends

The Padres have fared better at home, often covering spreads when their pitching holds steady and their lineup provides run support.

Diamondbacks vs. Padres Matchup Trends

Meetings between these clubs often trend toward high scoring, with the over hitting more often than not due to both teams’ offensive capabilities. However, close margins have been a theme, with many recent games decided by three runs or fewer.

Arizona vs. San Diego Game Info

Arizona vs San Diego starts on September 28, 2025 at 3:10 PM EST.

Spread: San Diego LOADING
Moneyline: Arizona LOADING, San Diego LOADING
Over/Under: LOADING

Arizona: (80-81)  |  San Diego: (89-72)

Remi's searched hard and found the best prop for this matchup: F. Tatis over 6.5 Fantasy Score.. Prices move—always shop for the best number.

Meetings between these clubs often trend toward high scoring, with the over hitting more often than not due to both teams’ offensive capabilities. However, close margins have been a theme, with many recent games decided by three runs or fewer.

ARI trend: The Diamondbacks have struggled on the road against division rivals, covering inconsistently despite flashes of offensive production.

SD trend: The Padres have fared better at home, often covering spreads when their pitching holds steady and their lineup provides run support.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Arizona vs. San Diego Odds

AI algorithm Remi is pouring through loads of stats on each line. In fact, anytime the Arizona vs San Diego trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance seemingly never follow normal, predictable patterns.

Arizona vs San Diego Opening Odds

ARI Moneyline: LOADING
SD Moneyline: LOADING
ARI Spread: LOADING
SD Spread: LOADING
Over/Under: LOADING

Arizona vs San Diego Live Odds

Games PTS ML SPR O/U
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
+100
-120
-1.5 (+175)
+1.5 (-215)
O 7 (-105)
U 7 (-115)
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
+100
-118
-1.5 (+172)
+1.5 (-210)
O 7.5 (-110)
U 7.5 (-110)
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
+136
-162
+1.5 (-160)
-1.5 (+130)
O 7.5 (-120)
U 7.5 (-102)
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
+110
-130
pk
pk
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
+108
-126
pk
pk
O 7 (-135)
U 7 (+115)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Arizona Diamondbacks vs. San Diego Padres on September 28, 2025 at Petco Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS