Tigers vs. Sox
Prediction, Odds & Props
Sep 26 | MLB AI Picks
Updated: 2025-09-24T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Detroit Tigers and Boston Red Sox square off at Fenway Park on September 26, 2025, in what should be an intriguing late-season American League clash with playoff implications. Both teams are fighting to maintain momentum, and with their contrasting styles, this matchup could hinge on execution in critical moments.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 26, 2025
Start Time: 7:10 PM EST
Venue: Fenway Park
Sox Record: (87-72)
Tigers Record: (86-73)
OPENING ODDS
DET Moneyline: +103
BOS Moneyline: -123
DET Spread: -1.5
BOS Spread: +1.5
Over/Under: 8.5
DET
Betting Trends
- The Detroit Tigers have struggled against the spread recently, dropping five of their last seven contests on the road, often failing to generate enough offense to cover.
BOS
Betting Trends
- The Boston Red Sox have been more reliable at Fenway, covering in four of their last six home games, largely due to strong offensive outbursts and timely bullpen performances.
MATCHUP TRENDS
- Interestingly, when these two clubs have met head-to-head, the underdog has covered in four of the last five matchups, and games at Fenway have often leaned toward the over, with six of the last eight meetings surpassing the projected run total thanks to both teams’ streaky offenses.
DET vs. BOS
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: R. Gonzalez over 5.5 Fantasy Score.
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Detroit vs Boston Red Prediction & Odds:
Free MLB Betting Insights for 9/26/25
From a stylistic perspective, this game sets up as a contrast between Detroit’s grind-it-out mentality and Boston’s quick-strike ability, with the Tigers needing to control tempo and minimize mistakes to keep the game close. Fenway’s quirks may also play a major role, testing Detroit’s defense in the outfield and amplifying Boston’s home-field edge, as the Red Sox have historically thrived at home. The Tigers’ lineup featuring Riley Greene and Spencer Torkelson will need to find a way to scratch across runs against a Boston pitching staff that has been stingy at Fenway, while the Red Sox will look to apply pressure from the opening inning and ride their crowd’s energy to put the Tigers on their heels early. Both teams enter with something to prove—Boston aiming to reinforce its standing as a dangerous postseason-caliber club, and Detroit fighting to demonstrate that its rebuild has matured into a competitive force capable of winning in hostile environments. Ultimately, this game will likely hinge on whether Detroit’s young arms can keep Boston’s lineup in check long enough for their offense to deliver timely production, or if the Red Sox’ relentless bats and home-field advantage overwhelm the Tigers and set the tone for another successful series at Fenway. This clash not only tests both clubs’ current form but also provides a telling preview of whether Detroit is ready to compete against established playoff contenders, while Boston will be eager to reinforce its identity as one of the most dangerous home teams in baseball.
Will Vest got the side to end it 💪
— Detroit Tigers (@tigers) September 26, 2025
Save energy at home with these tips: https://t.co/sm4zCCupj6 pic.twitter.com/wlwqsqwoje
Detroit Tigers MLB Preview
The Detroit Tigers head into Fenway Park to battle the Boston Red Sox knowing they face one of the toughest road environments in baseball, and for a team that has struggled with consistency away from home, this game will be a significant measuring stick for their growth. Detroit’s season has been defined by its young core, with players like Spencer Torkelson and Riley Greene carrying the weight of the offense, complemented by the steady contributions of Kerry Carpenter and Matt Vierling, yet this group has not always been able to deliver on the road with the same rhythm and power they show at Comerica Park. The Tigers’ offense often relies on situational hitting and manufacturing runs, and when they are able to put pressure on opposing pitchers through long at-bats and patient plate appearances, they can turn small opportunities into meaningful rallies, but their overreliance on a few key bats has made them vulnerable when those hitters go cold. On the pitching side, Tarik Skubal has emerged as one of the American League’s most consistent starters, giving the Tigers a legitimate ace who can neutralize even powerful lineups like Boston’s, while Casey Mize and Reese Olson provide depth that hints at a bright future for the rotation. However, the bullpen has been an area of concern, with high-leverage relievers like Jason Foley and Alex Lange needing to find consistency to protect leads against teams that excel in the late innings.
The Tigers’ defense will also be tested by Fenway Park’s unique dimensions, requiring sharp focus in the outfield to prevent Boston from turning doubles into momentum-shifting rallies. Manager A.J. Hinch will likely emphasize patience at the plate and aggressive baserunning to keep Boston’s pitchers under pressure, knowing that relying solely on the long ball won’t be enough in a hitter-friendly park that the Red Sox know how to exploit better than anyone. For Detroit, the key will be to start strong and avoid falling behind early, because once Boston’s offense finds its groove, the Tigers may struggle to claw their way back against a bullpen that has been more reliable at home. This game is an opportunity for Detroit to showcase that their rebuild is producing competitive baseball against playoff-caliber opponents, and while the odds may not favor them in this matchup, a disciplined approach at the plate, clean defense, and a dominant outing from their starting pitching could tilt the balance. If the Tigers are to pull off an upset in Boston, it will require both their young stars rising to the moment and their pitching staff delivering near-flawless execution in a ballpark that rarely forgives mistakes. For a franchise still proving it belongs in the postseason conversation, this game will be more than just another stop on the schedule—it will be a chance to validate the progress they’ve made and send a statement that Detroit is ready to contend in meaningful September baseball.

Credit: USA TODAY/IMAGN
Boston Red Sox MLB Preview
The Boston Red Sox enter this matchup against the Detroit Tigers at Fenway Park with a clear sense of identity and confidence, knowing their home field has long been one of their greatest weapons and that their lineup has the kind of explosive potential to dictate games early and often. Rafael Devers continues to be the centerpiece of the offense, providing both power and clutch hitting from the heart of the order, while Jarren Duran has thrived in the leadoff spot with his blend of speed and improved plate discipline, setting the tone for the rest of the lineup. Triston Casas brings balance with his power from the other side of the plate, while Trevor Story has provided veteran stability in the infield and timely contributions at the plate, helping Boston’s offense stretch beyond just one or two stars. The Red Sox also benefit from the unique design of Fenway Park, which allows them to pepper the Green Monster with doubles and generate rallies without always relying on the long ball, a dynamic that puts extra pressure on opposing pitchers to be precise with location. Pitching remains the X-factor for Boston, as young arms like Brayan Bello have shown flashes of ace-level talent but have occasionally struggled with consistency, though at home Bello and others in the rotation have generally been able to limit damage and hand the game over to a bullpen that has steadied as the season has progressed. Kenley Jansen continues to bring veteran leadership in the late innings, and the relievers as a whole have been more reliable at Fenway, feeding off the crowd’s energy in tight games.
Defensively, Boston must be sharp, particularly in the outfield, where Fenway’s quirks can turn routine plays into challenges, but their athleticism and communication have helped limit mistakes. Strategically, Alex Cora is likely to lean into Boston’s strengths by pushing for aggressive baserunning, patient at-bats to force high pitch counts, and situational hitting to put constant stress on Detroit’s pitching staff, which has been shaky at times on the road. The Red Sox understand that building early leads at home is critical, as it allows them to control the game’s rhythm and use their bullpen more effectively while keeping the pressure squarely on the Tigers’ young roster. With the playoff race intensifying, Boston cannot afford to overlook a scrappy Detroit squad, but they will know they hold the advantage in terms of lineup depth, home-field familiarity, and the ability to turn momentum quickly in their favor. If the Red Sox execute the way they have in recent weeks at Fenway, limiting defensive mistakes and trusting their offense to do damage, they will be well-positioned not only to secure a win in this matchup but also to continue building momentum toward a postseason push, reinforcing their reputation as one of the most dangerous teams in the American League when playing in front of their home crowd.
Guys who are Tremendously Locked In. pic.twitter.com/WZ2NRdhEN3
— Red Sox (@RedSox) September 25, 2025
Detroit vs. Boston Red Prop Picks (AI)
Detroit vs. Boston Red Prediction (AI)

Remi, our AI sports algorithm, has been pouring over mountains of data from every simulation between the Tigers and Sox and using recursive machine learning and industry leading AI to examine the data to a single cover probability.
Remi has been most focused on the growing emphasis human bettors tend to put on coaching factors between a Tigers team going up against a possibly tired Sox team. Trends look to say the true game analytics appear to reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Detroit vs Boston Red picks, computer picks Tigers vs Sox, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 3 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | CIN@LAD | GET FREE PICK NOW | 1 | – | |
MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 0 |
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MLB | 10/1 | BOS@NYY | GET FREE PICK NOW | 0 | – |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Tigers Betting Trends
The Detroit Tigers have struggled against the spread recently, dropping five of their last seven contests on the road, often failing to generate enough offense to cover.
Sox Betting Trends
The Boston Red Sox have been more reliable at Fenway, covering in four of their last six home games, largely due to strong offensive outbursts and timely bullpen performances.
Tigers vs. Sox Matchup Trends
Interestingly, when these two clubs have met head-to-head, the underdog has covered in four of the last five matchups, and games at Fenway have often leaned toward the over, with six of the last eight meetings surpassing the projected run total thanks to both teams’ streaky offenses.
Detroit vs. Boston Red Game Info
What time does Detroit vs Boston Red start on September 26, 2025?
Detroit vs Boston Red starts on September 26, 2025 at 7:10 PM EST.
Where is Detroit vs Boston Red being played?
Venue: Fenway Park.
What are the opening odds for Detroit vs Boston Red?
Spread: Boston Red +1.5
Moneyline: Detroit +103, Boston Red -123
Over/Under: 8.5
What are the records for Detroit vs Boston Red?
Detroit: (86-73) | Boston Red: (87-72)
What is the AI best bet for Detroit vs Boston Red?
Remi's searched hard and found the best prop for this matchup: R. Gonzalez over 5.5 Fantasy Score.. Prices move—always shop for the best number.
What are Detroit vs Boston Red trending bets?
Interestingly, when these two clubs have met head-to-head, the underdog has covered in four of the last five matchups, and games at Fenway have often leaned toward the over, with six of the last eight meetings surpassing the projected run total thanks to both teams’ streaky offenses.
What are Detroit trending bets?
DET trend: The Detroit Tigers have struggled against the spread recently, dropping five of their last seven contests on the road, often failing to generate enough offense to cover.
What are Boston Red trending bets?
BOS trend: The Boston Red Sox have been more reliable at Fenway, covering in four of their last six home games, largely due to strong offensive outbursts and timely bullpen performances.
Where can I find AI Picks for Detroit vs Boston Red?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Detroit vs. Boston Red Odds
Remi is pouring through loads of data on each line. In fact, anytime the Detroit vs Boston Red trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable betting trends.
Detroit vs Boston Red Opening Odds
DET Moneyline:
+103 BOS Moneyline: -123
DET Spread: -1.5
BOS Spread: +1.5
Over/Under: 8.5
Detroit vs Boston Red Live Odds
Games | PTS | ML | SPR | O/U | |
---|---|---|---|---|---|
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
|
–
–
|
+100
-120
|
-1.5 (+175)
+1.5 (-215)
|
O 7 (-105)
U 7 (-115)
|
|
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
|
–
–
|
+100
-118
|
-1.5 (+172)
+1.5 (-210)
|
O 7.5 (-110)
U 7.5 (-110)
|
|
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
|
–
–
|
+136
-162
|
+1.5 (-160)
-1.5 (+130)
|
O 7.5 (-120)
U 7.5 (-102)
|
|
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
|
–
–
|
+110
-130
|
pk
pk
|
|
|
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
|
–
–
|
+108
-126
|
pk
pk
|
O 7 (-135)
U 7 (+115)
|
MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Detroit Tigers vs. Boston Red Sox on September 26, 2025 at Fenway Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |