Tigers vs. Sox
Prediction, Odds & Props
Sep 26 | MLB AI Picks

Updated: 2025-09-24T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Detroit Tigers and Boston Red Sox square off at Fenway Park on September 26, 2025, in what should be an intriguing late-season American League clash with playoff implications. Both teams are fighting to maintain momentum, and with their contrasting styles, this matchup could hinge on execution in critical moments.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 26, 2025

Start Time: 7:10 PM EST​

Venue: Fenway Park​

Sox Record: (87-72)

Tigers Record: (86-73)

OPENING ODDS

DET Moneyline: +103

BOS Moneyline: -123

DET Spread: -1.5

BOS Spread: +1.5

Over/Under: 8.5

DET
Betting Trends

  • The Detroit Tigers have struggled against the spread recently, dropping five of their last seven contests on the road, often failing to generate enough offense to cover.

BOS
Betting Trends

  • The Boston Red Sox have been more reliable at Fenway, covering in four of their last six home games, largely due to strong offensive outbursts and timely bullpen performances.

MATCHUP TRENDS

  • Interestingly, when these two clubs have met head-to-head, the underdog has covered in four of the last five matchups, and games at Fenway have often leaned toward the over, with six of the last eight meetings surpassing the projected run total thanks to both teams’ streaky offenses.

DET vs. BOS
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: R. Gonzalez over 5.5 Fantasy Score.

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Detroit vs Boston Red Prediction & Odds:
Free MLB Betting Insights for 9/26/25

The Detroit Tigers and Boston Red Sox square off at Fenway Park on September 26, 2025, in a matchup that showcases two teams with very different identities but similar levels of urgency as the regular season winds down and playoff positioning sharpens into focus. The Tigers arrive with a young roster that has been molded around developing arms and budding offensive stars, a group that has shown promise but also revealed its inconsistency, particularly when faced with quality opponents on the road. Their pitching staff, led by Tarik Skubal, has been the backbone of their season, but questions remain about whether the bullpen can consistently shut the door late in games, especially against a Boston lineup that thrives on extending at-bats and wearing pitchers down. The Red Sox, on the other hand, are built around offensive firepower and the unique advantages of Fenway Park, where hitters like Rafael Devers, Jarren Duran, and Triston Casas can exploit the ballpark’s dimensions to produce extra-base hits and game-changing rallies. Boston’s pitching staff has shown flashes, particularly from young starters like Brayan Bello, but their success often depends on the bullpen being steady and limiting walks, an area that has occasionally created headaches for manager Alex Cora.

From a stylistic perspective, this game sets up as a contrast between Detroit’s grind-it-out mentality and Boston’s quick-strike ability, with the Tigers needing to control tempo and minimize mistakes to keep the game close. Fenway’s quirks may also play a major role, testing Detroit’s defense in the outfield and amplifying Boston’s home-field edge, as the Red Sox have historically thrived at home. The Tigers’ lineup featuring Riley Greene and Spencer Torkelson will need to find a way to scratch across runs against a Boston pitching staff that has been stingy at Fenway, while the Red Sox will look to apply pressure from the opening inning and ride their crowd’s energy to put the Tigers on their heels early. Both teams enter with something to prove—Boston aiming to reinforce its standing as a dangerous postseason-caliber club, and Detroit fighting to demonstrate that its rebuild has matured into a competitive force capable of winning in hostile environments. Ultimately, this game will likely hinge on whether Detroit’s young arms can keep Boston’s lineup in check long enough for their offense to deliver timely production, or if the Red Sox’ relentless bats and home-field advantage overwhelm the Tigers and set the tone for another successful series at Fenway. This clash not only tests both clubs’ current form but also provides a telling preview of whether Detroit is ready to compete against established playoff contenders, while Boston will be eager to reinforce its identity as one of the most dangerous home teams in baseball.

Detroit Tigers MLB Preview

The Detroit Tigers head into Fenway Park to battle the Boston Red Sox knowing they face one of the toughest road environments in baseball, and for a team that has struggled with consistency away from home, this game will be a significant measuring stick for their growth. Detroit’s season has been defined by its young core, with players like Spencer Torkelson and Riley Greene carrying the weight of the offense, complemented by the steady contributions of Kerry Carpenter and Matt Vierling, yet this group has not always been able to deliver on the road with the same rhythm and power they show at Comerica Park. The Tigers’ offense often relies on situational hitting and manufacturing runs, and when they are able to put pressure on opposing pitchers through long at-bats and patient plate appearances, they can turn small opportunities into meaningful rallies, but their overreliance on a few key bats has made them vulnerable when those hitters go cold. On the pitching side, Tarik Skubal has emerged as one of the American League’s most consistent starters, giving the Tigers a legitimate ace who can neutralize even powerful lineups like Boston’s, while Casey Mize and Reese Olson provide depth that hints at a bright future for the rotation. However, the bullpen has been an area of concern, with high-leverage relievers like Jason Foley and Alex Lange needing to find consistency to protect leads against teams that excel in the late innings.

The Tigers’ defense will also be tested by Fenway Park’s unique dimensions, requiring sharp focus in the outfield to prevent Boston from turning doubles into momentum-shifting rallies. Manager A.J. Hinch will likely emphasize patience at the plate and aggressive baserunning to keep Boston’s pitchers under pressure, knowing that relying solely on the long ball won’t be enough in a hitter-friendly park that the Red Sox know how to exploit better than anyone. For Detroit, the key will be to start strong and avoid falling behind early, because once Boston’s offense finds its groove, the Tigers may struggle to claw their way back against a bullpen that has been more reliable at home. This game is an opportunity for Detroit to showcase that their rebuild is producing competitive baseball against playoff-caliber opponents, and while the odds may not favor them in this matchup, a disciplined approach at the plate, clean defense, and a dominant outing from their starting pitching could tilt the balance. If the Tigers are to pull off an upset in Boston, it will require both their young stars rising to the moment and their pitching staff delivering near-flawless execution in a ballpark that rarely forgives mistakes. For a franchise still proving it belongs in the postseason conversation, this game will be more than just another stop on the schedule—it will be a chance to validate the progress they’ve made and send a statement that Detroit is ready to contend in meaningful September baseball.

The Detroit Tigers and Boston Red Sox square off at Fenway Park on September 26, 2025, in what should be an intriguing late-season American League clash with playoff implications. Both teams are fighting to maintain momentum, and with their contrasting styles, this matchup could hinge on execution in critical moments. Detroit vs Boston Red AI Prediction: Free MLB Betting Insights for Sep 26. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Boston Red Sox MLB Preview

The Boston Red Sox enter this matchup against the Detroit Tigers at Fenway Park with a clear sense of identity and confidence, knowing their home field has long been one of their greatest weapons and that their lineup has the kind of explosive potential to dictate games early and often. Rafael Devers continues to be the centerpiece of the offense, providing both power and clutch hitting from the heart of the order, while Jarren Duran has thrived in the leadoff spot with his blend of speed and improved plate discipline, setting the tone for the rest of the lineup. Triston Casas brings balance with his power from the other side of the plate, while Trevor Story has provided veteran stability in the infield and timely contributions at the plate, helping Boston’s offense stretch beyond just one or two stars. The Red Sox also benefit from the unique design of Fenway Park, which allows them to pepper the Green Monster with doubles and generate rallies without always relying on the long ball, a dynamic that puts extra pressure on opposing pitchers to be precise with location. Pitching remains the X-factor for Boston, as young arms like Brayan Bello have shown flashes of ace-level talent but have occasionally struggled with consistency, though at home Bello and others in the rotation have generally been able to limit damage and hand the game over to a bullpen that has steadied as the season has progressed. Kenley Jansen continues to bring veteran leadership in the late innings, and the relievers as a whole have been more reliable at Fenway, feeding off the crowd’s energy in tight games.

Defensively, Boston must be sharp, particularly in the outfield, where Fenway’s quirks can turn routine plays into challenges, but their athleticism and communication have helped limit mistakes. Strategically, Alex Cora is likely to lean into Boston’s strengths by pushing for aggressive baserunning, patient at-bats to force high pitch counts, and situational hitting to put constant stress on Detroit’s pitching staff, which has been shaky at times on the road. The Red Sox understand that building early leads at home is critical, as it allows them to control the game’s rhythm and use their bullpen more effectively while keeping the pressure squarely on the Tigers’ young roster. With the playoff race intensifying, Boston cannot afford to overlook a scrappy Detroit squad, but they will know they hold the advantage in terms of lineup depth, home-field familiarity, and the ability to turn momentum quickly in their favor. If the Red Sox execute the way they have in recent weeks at Fenway, limiting defensive mistakes and trusting their offense to do damage, they will be well-positioned not only to secure a win in this matchup but also to continue building momentum toward a postseason push, reinforcing their reputation as one of the most dangerous teams in the American League when playing in front of their home crowd.

Detroit vs. Boston Red Prop Picks (AI)

Remi is pouring through mountains of datapoints on each team. In fact, anytime the Tigers and Sox play there’s always several intriguing observations to key in on. Not to mention games played at Fenway Park in Sep rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: R. Gonzalez over 5.5 Fantasy Score.

Detroit vs. Boston Red Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over mountains of data from every simulation between the Tigers and Sox and using recursive machine learning and industry leading AI to examine the data to a single cover probability.

Remi has been most focused on the growing emphasis human bettors tend to put on coaching factors between a Tigers team going up against a possibly tired Sox team. Trends look to say the true game analytics appear to reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Detroit vs Boston Red picks, computer picks Tigers vs Sox, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 BOS@NYY UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 CIN@LAD GET FREE PICK NOW 1
MLB 10/1 BOS@NYY UNLOCK THIS PICK 0 INTEL Locked INTEL
MLB 10/1 BOS@NYY GET FREE PICK NOW 0

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Tigers Betting Trends

The Detroit Tigers have struggled against the spread recently, dropping five of their last seven contests on the road, often failing to generate enough offense to cover.

Sox Betting Trends

The Boston Red Sox have been more reliable at Fenway, covering in four of their last six home games, largely due to strong offensive outbursts and timely bullpen performances.

Tigers vs. Sox Matchup Trends

Interestingly, when these two clubs have met head-to-head, the underdog has covered in four of the last five matchups, and games at Fenway have often leaned toward the over, with six of the last eight meetings surpassing the projected run total thanks to both teams’ streaky offenses.

Detroit vs. Boston Red Game Info

Detroit vs Boston Red starts on September 26, 2025 at 7:10 PM EST.

Spread: Boston Red +1.5
Moneyline: Detroit +103, Boston Red -123
Over/Under: 8.5

Detroit: (86-73)  |  Boston Red: (87-72)

Remi's searched hard and found the best prop for this matchup: R. Gonzalez over 5.5 Fantasy Score.. Prices move—always shop for the best number.

Interestingly, when these two clubs have met head-to-head, the underdog has covered in four of the last five matchups, and games at Fenway have often leaned toward the over, with six of the last eight meetings surpassing the projected run total thanks to both teams’ streaky offenses.

DET trend: The Detroit Tigers have struggled against the spread recently, dropping five of their last seven contests on the road, often failing to generate enough offense to cover.

BOS trend: The Boston Red Sox have been more reliable at Fenway, covering in four of their last six home games, largely due to strong offensive outbursts and timely bullpen performances.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Detroit vs. Boston Red Odds

Remi is pouring through loads of data on each line. In fact, anytime the Detroit vs Boston Red trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable betting trends.

Detroit vs Boston Red Opening Odds

DET Moneyline: +103
BOS Moneyline: -123
DET Spread: -1.5
BOS Spread: +1.5
Over/Under: 8.5

Detroit vs Boston Red Live Odds

Games PTS ML SPR O/U
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
+100
-120
-1.5 (+175)
+1.5 (-215)
O 7 (-105)
U 7 (-115)
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
+100
-118
-1.5 (+172)
+1.5 (-210)
O 7.5 (-110)
U 7.5 (-110)
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
+136
-162
+1.5 (-160)
-1.5 (+130)
O 7.5 (-120)
U 7.5 (-102)
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
+110
-130
pk
pk
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
+108
-126
pk
pk
O 7 (-135)
U 7 (+115)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Detroit Tigers vs. Boston Red Sox on September 26, 2025 at Fenway Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS