Orioles vs. Yankees
Prediction, Odds & Props
Sep 26 | MLB AI Picks

Updated: 2025-09-24T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Baltimore Orioles and New York Yankees renew their AL East rivalry on September 26, 2025, at Yankee Stadium in a matchup that could carry major postseason implications for both teams. With two powerful lineups and pitching staffs seeking consistency, this contest has the makings of a hard-fought division battle under the bright lights of the Bronx.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 26, 2025

Start Time: 7:05 PM EST​

Venue: Yankee Stadium​

Yankees Record: (91-68)

Orioles Record: (75-84)

OPENING ODDS

BAL Moneyline: +125

NYY Moneyline: -149

BAL Spread: +1.5

NYY Spread: -1.5

Over/Under: 8.5

BAL
Betting Trends

  • The Orioles have been one of the stronger run line performers in the league, especially on the road, where their balanced offense and deep bullpen have helped them cover consistently.

NYY
Betting Trends

  • The Yankees have been less reliable against the run line at home, often winning outright but struggling to extend margins in tight, low-scoring affairs.

MATCHUP TRENDS

  • Games between these teams in recent seasons have frequently leaned toward the over, with both lineups capable of explosive innings, though close late-inning finishes have also made run line results unpredictable.

BAL vs. NYY
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: W. Warren over 18.5 Fantasy Score.

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Baltimore vs New York Prediction & Odds:
Free MLB Betting Insights for 9/26/25

The September 26, 2025 showdown between the Baltimore Orioles and the New York Yankees at Yankee Stadium has all the ingredients of a late-season AL East thriller, pitting two powerhouses with postseason ambitions against each other in one of the sport’s most historic rivalries, and with both lineups capable of producing fireworks and both pitching staffs trying to lock into form before October, this game promises to be a showcase of intensity, strategy, and pressure-filled moments. The Orioles come into this contest as one of the most balanced teams in the American League, built around a young core of hitters who have grown into legitimate stars and a pitching staff that, while not elite, has been consistent enough to keep them in games long enough for their offense to take over, and their ability to perform on the road has been one of the defining features of their rise. Baltimore’s bullpen has been a particular strength, allowing them to shorten games and play with confidence late, though they’ll need to be sharp against a Yankees lineup that thrives on power and can change the momentum of a game with a single swing. The Yankees, meanwhile, have leaned heavily on their top bats, with sluggers anchoring the middle of the order and carrying much of the run production, and while they have often come out on top at home, their inconsistency against the run line points to an inability to always create separation, a factor that could loom large against a Baltimore team that plays close games exceptionally well. New York’s rotation has talent but has struggled with durability and command at times, and the pressure will fall on their starter in this game to avoid falling behind early, because the Orioles’ ability to grind out at-bats and wear down opposing pitchers is one of the best in baseball.

Defensively, both teams are solid, but Baltimore’s athleticism and depth give them a slight edge, particularly in the outfield, where preventing extra-base hits at Yankee Stadium’s quirky dimensions could save critical runs. Special teams and situational execution could also decide this contest, as both sides have had moments where runners in scoring position opportunities either lifted them to victory or doomed them in tight losses, and in games like this, one clutch hit or defensive stop could define the night. The atmosphere in the Bronx will be electric, with fans fully aware of the stakes and eager to see their team handle a divisional rival, but the Orioles have shown resilience in hostile environments all season and are unlikely to be fazed by the noise. Ultimately, this matchup boils down to whether Baltimore’s balance and depth can overcome New York’s star power and home-field advantage, and the outcome will likely come down to late-inning pitching duels and which lineup can take advantage of its opportunities. With playoff seeding on the line and two teams that know each other all too well, this game has all the makings of not just another entry in the long Orioles-Yankees history but a defining contest that could shape the trajectory of both teams heading into October.

Baltimore Orioles MLB Preview

The Baltimore Orioles head into their September 26, 2025 showdown with the New York Yankees at Yankee Stadium with confidence that their balanced roster, deep bullpen, and gritty road performances can continue to carry them as one of the most dangerous teams in the American League, and they know that beating the Yankees on their own turf would not only boost their postseason chances but also send a statement about their ability to handle pressure environments. Baltimore’s offense has evolved into one of the most consistent in the league, driven by a mix of young stars who provide athleticism, power, and speed, and seasoned veterans who bring stability and leadership, giving the lineup a well-rounded look that can attack opposing pitchers in multiple ways. Unlike the Yankees’ power-heavy approach, the Orioles are comfortable manufacturing runs, stringing together hits, drawing walks, and capitalizing on defensive miscues, which makes them particularly dangerous in tight contests where one extra baserunner can turn the tide. Their starting rotation has been steady if not dominant, often keeping them in games long enough to allow their offense to break through, and the pressure will be on their starter to navigate a Yankees lineup loaded with sluggers who feast on mistakes, especially in the short porch dimensions of Yankee Stadium.

The bullpen has been a hallmark of the Orioles’ success, shortening games by slamming the door in the late innings and giving the team confidence that even a slim lead can hold up, and this edge could prove decisive against a Yankees relief corps that has shown occasional vulnerability. Defensively, Baltimore’s athleticism has been a strength, with rangy outfielders cutting off extra-base hits and infielders turning critical double plays, and in a game where preventing Yankees hitters from extending innings is crucial, the Orioles’ clean defense could be the difference. On the road, Baltimore has built a reputation for resilience, regularly covering the run line and proving capable of silencing hostile crowds by playing disciplined, mistake-free baseball, and they’ll need to embrace that same mentality here, staying patient at the plate while not giving away free outs on defense or the bases. Special teams, such as their baserunning aggressiveness and ability to take an extra base, may also tilt the game in their favor, especially if they can put pressure on New York’s defense and force hurried throws. For the Orioles, this game is less about star power and more about execution, depth, and maintaining their identity as a balanced ballclub that doesn’t need to rely on any one player to carry the load, and if they can stick to that formula, they have every chance of leaving the Bronx with a win that would both frustrate their divisional rivals and reinforce their standing as a legitimate contender in the American League playoff race.

The Baltimore Orioles and New York Yankees renew their AL East rivalry on September 26, 2025, at Yankee Stadium in a matchup that could carry major postseason implications for both teams. With two powerful lineups and pitching staffs seeking consistency, this contest has the makings of a hard-fought division battle under the bright lights of the Bronx. Baltimore vs New York AI Prediction: Free MLB Betting Insights for Sep 26. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

New York Yankees MLB Preview

The New York Yankees head into their September 26, 2025 clash against the Baltimore Orioles at Yankee Stadium with the weight of postseason expectations and the energy of a home crowd that demands results, and they know that every game against a divisional rival this late in the season carries added urgency as they try to lock in their playoff seeding. Offensively, the Yankees have remained true to their identity, built around one of the most feared middle-of-the-order groups in baseball, with sluggers who can shift momentum in an instant and supporting bats that provide depth and balance across the lineup, though at times their overreliance on the long ball has left them vulnerable when opposing pitchers avoid mistakes. In Yankee Stadium’s homer-friendly dimensions, this power-oriented approach often pays dividends, but against a disciplined Baltimore pitching staff that attacks the strike zone and limits big innings, the Yankees will need to execute in situational hitting to avoid being stranded in high-leverage moments. Their starting rotation has shown flashes of dominance, but inconsistency in command and health has created uncertainty, and this matchup will test their ability to set the tone early, because Baltimore has proven adept at wearing down pitchers with patient at-bats that drive up pitch counts.

The Yankees’ bullpen, long a strength of the franchise, remains a critical weapon in closing out tight games, but the unit has also had its share of hiccups, particularly when asked to protect slim leads, and the pressure will be amplified against an Orioles team that thrives late in contests. Defensively, New York has cleaned up mistakes compared to past seasons, but fundamentals will be crucial here, as Baltimore is aggressive on the bases and quick to exploit lapses. The Yankees also know that their home-field advantage is one of their greatest assets, as the Bronx crowd creates a cauldron of energy that opponents often struggle to handle, and feeding off that atmosphere can give their hitters and pitchers the extra edge they need to rise to the occasion. Special teams and execution in key moments will matter as well, because against a balanced Orioles team, the Yankees cannot afford to miss opportunities with runners in scoring position or give away outs on the bases. Ultimately, for New York this game is about proving that their blend of power, pitching depth, and home-field advantage is enough to outlast a divisional rival built on balance and resiliency, and securing a win here would not only solidify their postseason outlook but also send a message to the rest of the league that they are prepared for the intensity of October baseball.

Baltimore vs. New York Prop Picks (AI)

AI algorithm Remi is pouring through loads of data on each player. In fact, anytime the Orioles and Yankees play there’s always several intriguing trends to key in on. Not to mention games played at Yankee Stadium in Sep almost always follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: W. Warren over 18.5 Fantasy Score.

Baltimore vs. New York Prediction (AI)

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Remi, our AI sports genius, has been pouring over millions of data from every angle between the Orioles and Yankees and using recursive machine learning and cutting-edge AI to boil down the data to a single cover probability.

Remi has been most fixated on the linear correlation of weight human bettors regularly put on coaching factors between a Orioles team going up against a possibly unhealthy Yankees team. Trends look to say the true game analytics might reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Baltimore vs New York picks, computer picks Orioles vs Yankees, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 BOS@NYY UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 CIN@LAD GET FREE PICK NOW 1
MLB 10/1 BOS@NYY UNLOCK THIS PICK 0 INTEL Locked INTEL
MLB 10/1 BOS@NYY GET FREE PICK NOW 0

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Orioles Betting Trends

The Orioles have been one of the stronger run line performers in the league, especially on the road, where their balanced offense and deep bullpen have helped them cover consistently.

Yankees Betting Trends

The Yankees have been less reliable against the run line at home, often winning outright but struggling to extend margins in tight, low-scoring affairs.

Orioles vs. Yankees Matchup Trends

Games between these teams in recent seasons have frequently leaned toward the over, with both lineups capable of explosive innings, though close late-inning finishes have also made run line results unpredictable.

Baltimore vs. New York Game Info

Baltimore vs New York starts on September 26, 2025 at 7:05 PM EST.

Spread: New York -1.5
Moneyline: Baltimore +125, New York -149
Over/Under: 8.5

Baltimore: (75-84)  |  New York: (91-68)

Remi's searched hard and found the best prop for this matchup: W. Warren over 18.5 Fantasy Score.. Prices move—always shop for the best number.

Games between these teams in recent seasons have frequently leaned toward the over, with both lineups capable of explosive innings, though close late-inning finishes have also made run line results unpredictable.

BAL trend: The Orioles have been one of the stronger run line performers in the league, especially on the road, where their balanced offense and deep bullpen have helped them cover consistently.

NYY trend: The Yankees have been less reliable against the run line at home, often winning outright but struggling to extend margins in tight, low-scoring affairs.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Baltimore vs. New York Odds

Remi is pouring through tons of data on each player. In fact, anytime the Baltimore vs New York trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable betting trends.

Baltimore vs New York Opening Odds

BAL Moneyline: +125
NYY Moneyline: -149
BAL Spread: +1.5
NYY Spread: -1.5
Over/Under: 8.5

Baltimore vs New York Live Odds

Games PTS ML SPR O/U
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
+100
-120
-1.5 (+175)
+1.5 (-215)
O 7 (-105)
U 7 (-115)
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
+100
-118
-1.5 (+172)
+1.5 (-210)
O 7.5 (-110)
U 7.5 (-110)
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
+136
-162
+1.5 (-160)
-1.5 (+130)
O 7.5 (-120)
U 7.5 (-102)
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
+110
-130
pk
pk
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
+108
-126
pk
pk
O 7 (-135)
U 7 (+115)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Baltimore Orioles vs. New York Yankees on September 26, 2025 at Yankee Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS