Diamondbacks vs. Padres
Prediction, Odds & Props
Sep 26 | MLB AI Picks

Updated: 2025-09-24T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Arizona Diamondbacks and San Diego Padres face off at Petco Park on September 26, 2025, in an NL West matchup that pits Arizona’s youth and speed against San Diego’s star-driven roster. With playoff positioning still in flux, both clubs will look to capitalize on divisional bragging rights and momentum in the season’s final stretch.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 26, 2025

Start Time: 9:40 PM EST​

Venue: Petco Park​

Padres Record: (87-72)

Diamondbacks Record: (80-79)

OPENING ODDS

ARI Moneyline: +122

SD Moneyline: -147

ARI Spread: +1.5

SD Spread: -1.5

Over/Under: 7.5

ARI
Betting Trends

  • The Arizona Diamondbacks have struggled against the spread recently, covering just three of their last nine games as inconsistency from their rotation has hurt them late.

SD
Betting Trends

  • The San Diego Padres have been steadier at Petco Park, covering in five of their last seven home games behind strong outings from their veteran core.

MATCHUP TRENDS

  • Interestingly, six of the last ten meetings between these two teams have gone over the total, as both lineups tend to produce fireworks when they meet despite Petco Park’s reputation as a pitcher-friendly stadium.

ARI vs. SD
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Merrill over 5.5 Fantasy Score.

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Arizona vs San Diego Prediction & Odds:
Free MLB Betting Insights for 9/26/25

The upcoming matchup between the Arizona Diamondbacks and the San Diego Padres on September 26, 2025, at Petco Park offers a fascinating late-season contest between two clubs that have taken different paths in the National League but remain dangerous in their own right, with Arizona leaning on power and timely hitting while San Diego boasts one of the deepest rosters in the league and a pitching staff built to dominate in big spots. The Diamondbacks arrive in San Diego with their season defined by streaks, at times showing the explosiveness that carried them in the postseason not long ago, led by cornerstone talents like Corbin Carroll and Ketel Marte, but also suffering from stretches of inconsistency where their rotation depth and bullpen management have faltered, an issue that could be magnified against a Padres team that excels at putting pressure on opposing pitchers through long at-bats, situational hitting, and aggressiveness on the bases.

San Diego, for its part, has once again showcased why Petco Park is such a tough place to play, building on strong home splits and using their stars like Fernando Tatís Jr., Manny Machado, and Xander Bogaerts to create mismatches while younger talent continues to provide energy at the bottom of the order, and their rotation, anchored by proven arms such as Yu Darvish and Joe Musgrove along with high-upside young pitchers, has positioned them to handle the grind of late September when every inning matters. The key to this matchup likely lies in whether Arizona’s pitching staff can contain San Diego’s relentless approach, as the Diamondbacks will need strong starts and clean defensive play to offset the Padres’ ability to generate runs from both power and speed, while the Padres must remain wary of Arizona’s ability to turn games quickly with extra-base hits and aggressive base running that can punish even minor mistakes. With postseason implications still shaping the narrative, both teams will be playing with urgency, the Padres looking to secure a higher seed and maintain momentum while the Diamondbacks fight to prove they can still hang with one of the most complete teams in the National League, making this a clash of styles where the balance between Arizona’s unpredictability and San Diego’s steady execution could determine not just this game but the tone for how each team enters the final stretch of the season.

Arizona Diamondbacks MLB Preview

The Arizona Diamondbacks enter this matchup against the San Diego Padres with plenty to prove, as their season has been defined by inconsistency, streaky play, and the challenge of sustaining momentum against top-tier competition in the National League West, yet they remain a club with the potential to cause trouble for even the strongest teams when their lineup and pitching staff click together at the right time, and facing a divisional foe like San Diego provides both a measuring stick and an opportunity to make up crucial ground in the standings. Offensively, Arizona has leaned heavily on the bat of Corbin Carroll, whose combination of speed, contact hitting, and developing power has given the Diamondbacks a dynamic presence at the top of the order, while Christian Walker remains the club’s steady source of middle-of-the-order power, consistently providing home run threats and extra-base hits to drive in runs. Ketel Marte’s switch-hitting ability and knack for putting the ball in play continue to serve as the glue in the batting order, helping create chances for the team to capitalize in key situations, and prospects like Jordan Lawlar and Jake McCarthy are beginning to get opportunities to contribute, offering a glimpse of both the future and additional lineup depth.

However, the Diamondbacks have often struggled with situational hitting, leaving runners stranded in scoring position at an alarming rate, which has prevented them from maximizing opportunities and has turned winnable games into frustrating losses. On the pitching side, Arizona’s ace Zac Gallen continues to be the face of the staff, a strike-thrower with a sharp breaking ball and the poise to pitch deep into games, but behind him the rotation has been spotty, with Merrill Kelly providing flashes of quality but struggling to stay healthy and the back end often relying on young arms still adjusting to the grind of MLB lineups. The bullpen remains a sore spot for the team, as blown saves and late-inning collapses have haunted them, putting added pressure on the offense to generate large leads that can survive those mistakes, though there have been improvements from relievers like Kevin Ginkel and Paul Sewald, who provide some late-game reliability when used carefully. Defensively, Arizona has athleticism across the diamond, with Carroll’s range in the outfield and Lawlar’s improving glove at shortstop giving them stability, yet lapses in fundamentals have occasionally cost them. As they head into this matchup with San Diego, the Diamondbacks know they must control the running game, limit free passes, and make the most of scoring opportunities against a formidable Padres staff that rarely gives up easy runs, and the coaching staff will be emphasizing execution, discipline at the plate, and keeping games close enough to allow their stars to make a difference. This series carries added weight not just because of the standings, but also because Arizona’s young roster must demonstrate growth, resilience, and the ability to compete consistently under pressure, and if Carroll, Walker, and Gallen lead the way, the Diamondbacks could transform this matchup into a chance to reassert themselves in the divisional race, proving that they are not simply a team developing for the future but one capable of creating problems for contenders in the present.

The Arizona Diamondbacks and San Diego Padres face off at Petco Park on September 26, 2025, in an NL West matchup that pits Arizona’s youth and speed against San Diego’s star-driven roster. With playoff positioning still in flux, both clubs will look to capitalize on divisional bragging rights and momentum in the season’s final stretch. Arizona vs San Diego AI Prediction: Free MLB Betting Insights for Sep 26. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Diego Padres MLB Preview

The San Diego Padres enter this contest against the Arizona Diamondbacks with high expectations and the pressure of delivering on a roster that has been built to win now, featuring both established stars and younger talent in a competitive NL West environment where every divisional series carries postseason implications, and with the Padres still aiming to solidify their playoff position, this matchup represents a crucial opportunity to assert dominance over a team that has long been trying to climb into contention. At the heart of San Diego’s offensive attack is Fernando Tatis Jr., who continues to be one of the most electric players in the league with his combination of power, speed, and flair that ignites the lineup, while Juan Soto’s blend of patience and slugging ability makes him an on-base machine capable of changing the game with a single swing. Manny Machado provides the steady veteran presence, offering both leadership and consistent production, while players like Xander Bogaerts and Jake Cronenworth round out a lineup that is as deep as it is versatile, giving manager Mike Shildt the ability to adapt based on pitching matchups. The Padres have shown the ability to produce explosive offensive outbursts, particularly when they string together quality at-bats and force opposing pitchers into stressful situations, but at times their lineup has gone cold, leading to frustrating droughts in close games.

On the mound, San Diego continues to rely heavily on Yu Darvish’s veteran craftiness, the high-velocity arsenal of Joe Musgrove when healthy, and the developing consistency of Michael King, who has stepped into a larger role, while the bullpen has emerged as a key strength with Robert Suarez locking down saves and setup men like Adrian Morejon and Yuki Matsui providing quality innings in high-leverage situations. One of the Padres’ biggest assets is their ability to shorten games with strong late-inning relief, which has been particularly important in close divisional battles where every mistake can swing momentum. Defensively, the Padres are one of the sharper units in baseball, with Tatis Jr. showcasing his elite athleticism in the outfield, Machado’s Gold Glove-level defense anchoring third base, and Ha-Seong Kim bringing versatility and range to the infield, giving San Diego the ability to turn potential rallies into quick outs. As they prepare to host the Diamondbacks, the Padres know they have to guard against complacency, as Arizona’s young talent is more than capable of punishing lapses in execution, and Shildt will emphasize the need to apply pressure early, control the tempo of the game, and avoid allowing Arizona to hang around late where bullpen swings can prove costly. San Diego’s challenge has often been maintaining focus over a long season, but in a series like this, their experience, depth, and star power position them as clear favorites, provided they can back up their talent with consistent execution. With the home crowd behind them at Petco Park and the stakes continuing to rise as the postseason approaches, the Padres have the chance to not only secure another divisional win but also reinforce their status as one of the most dangerous teams in the National League when everything is clicking.

Arizona vs. San Diego Prop Picks (AI)

Remi is pouring through loads of stats on each line. In fact, anytime the Diamondbacks and Padres play there’s always several intriguing observations to key in on. Not to mention games played at Petco Park in Sep seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: J. Merrill over 5.5 Fantasy Score.

Arizona vs. San Diego Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over mountains of data from every angle between the Diamondbacks and Padres and using recursive machine learning and kick-ass AI to examine the data to a single cover probability.

Remi has been most watching on the trending weight knucklehead sportsbettors tend to put on San Diego’s strength factors between a Diamondbacks team going up against a possibly unhealthy Padres team. Trends look to say the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

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Below is our current AI Arizona vs San Diego picks, computer picks Diamondbacks vs Padres, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 BOS@NYY UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 CIN@LAD GET FREE PICK NOW 1
MLB 10/1 BOS@NYY UNLOCK THIS PICK 0 INTEL Locked INTEL
MLB 10/1 BOS@NYY GET FREE PICK NOW 0

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Diamondbacks Betting Trends

The Arizona Diamondbacks have struggled against the spread recently, covering just three of their last nine games as inconsistency from their rotation has hurt them late.

Padres Betting Trends

The San Diego Padres have been steadier at Petco Park, covering in five of their last seven home games behind strong outings from their veteran core.

Diamondbacks vs. Padres Matchup Trends

Interestingly, six of the last ten meetings between these two teams have gone over the total, as both lineups tend to produce fireworks when they meet despite Petco Park’s reputation as a pitcher-friendly stadium.

Arizona vs. San Diego Game Info

Arizona vs San Diego starts on September 26, 2025 at 9:40 PM EST.

Spread: San Diego -1.5
Moneyline: Arizona +122, San Diego -147
Over/Under: 7.5

Arizona: (80-79)  |  San Diego: (87-72)

Remi's searched hard and found the best prop for this matchup: J. Merrill over 5.5 Fantasy Score.. Prices move—always shop for the best number.

Interestingly, six of the last ten meetings between these two teams have gone over the total, as both lineups tend to produce fireworks when they meet despite Petco Park’s reputation as a pitcher-friendly stadium.

ARI trend: The Arizona Diamondbacks have struggled against the spread recently, covering just three of their last nine games as inconsistency from their rotation has hurt them late.

SD trend: The San Diego Padres have been steadier at Petco Park, covering in five of their last seven home games behind strong outings from their veteran core.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Arizona vs. San Diego Odds

AI algorithm Remi is pouring through tons of data on each player. In fact, anytime the Arizona vs San Diego trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance seemingly never follow normal, predictable betting trends.

Arizona vs San Diego Opening Odds

ARI Moneyline: +122
SD Moneyline: -147
ARI Spread: +1.5
SD Spread: -1.5
Over/Under: 7.5

Arizona vs San Diego Live Odds

Games PTS ML SPR O/U
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
+100
-120
-1.5 (+175)
+1.5 (-215)
O 7 (-105)
U 7 (-115)
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
+100
-118
-1.5 (+172)
+1.5 (-210)
O 7.5 (-110)
U 7.5 (-110)
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
+136
-162
+1.5 (-160)
-1.5 (+130)
O 7.5 (-120)
U 7.5 (-102)
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
+110
-130
pk
pk
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
+108
-126
pk
pk
O 7 (-135)
U 7 (+115)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Arizona Diamondbacks vs. San Diego Padres on September 26, 2025 at Petco Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS