Diamondbacks vs. Padres
Prediction, Odds & Props
Sep 26 | MLB AI Picks
Updated: 2025-09-24T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Arizona Diamondbacks and San Diego Padres face off at Petco Park on September 26, 2025, in an NL West matchup that pits Arizona’s youth and speed against San Diego’s star-driven roster. With playoff positioning still in flux, both clubs will look to capitalize on divisional bragging rights and momentum in the season’s final stretch.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 26, 2025
Start Time: 9:40 PM EST
Venue: Petco Park
Padres Record: (87-72)
Diamondbacks Record: (80-79)
OPENING ODDS
ARI Moneyline: +122
SD Moneyline: -147
ARI Spread: +1.5
SD Spread: -1.5
Over/Under: 7.5
ARI
Betting Trends
- The Arizona Diamondbacks have struggled against the spread recently, covering just three of their last nine games as inconsistency from their rotation has hurt them late.
SD
Betting Trends
- The San Diego Padres have been steadier at Petco Park, covering in five of their last seven home games behind strong outings from their veteran core.
MATCHUP TRENDS
- Interestingly, six of the last ten meetings between these two teams have gone over the total, as both lineups tend to produce fireworks when they meet despite Petco Park’s reputation as a pitcher-friendly stadium.
ARI vs. SD
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Merrill over 5.5 Fantasy Score.
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Arizona vs San Diego Prediction & Odds:
Free MLB Betting Insights for 9/26/25
San Diego, for its part, has once again showcased why Petco Park is such a tough place to play, building on strong home splits and using their stars like Fernando Tatís Jr., Manny Machado, and Xander Bogaerts to create mismatches while younger talent continues to provide energy at the bottom of the order, and their rotation, anchored by proven arms such as Yu Darvish and Joe Musgrove along with high-upside young pitchers, has positioned them to handle the grind of late September when every inning matters. The key to this matchup likely lies in whether Arizona’s pitching staff can contain San Diego’s relentless approach, as the Diamondbacks will need strong starts and clean defensive play to offset the Padres’ ability to generate runs from both power and speed, while the Padres must remain wary of Arizona’s ability to turn games quickly with extra-base hits and aggressive base running that can punish even minor mistakes. With postseason implications still shaping the narrative, both teams will be playing with urgency, the Padres looking to secure a higher seed and maintain momentum while the Diamondbacks fight to prove they can still hang with one of the most complete teams in the National League, making this a clash of styles where the balance between Arizona’s unpredictability and San Diego’s steady execution could determine not just this game but the tone for how each team enters the final stretch of the season.
Final. pic.twitter.com/JcKBohgdof
— Arizona Diamondbacks (@Dbacks) September 25, 2025
Arizona Diamondbacks MLB Preview
The Arizona Diamondbacks enter this matchup against the San Diego Padres with plenty to prove, as their season has been defined by inconsistency, streaky play, and the challenge of sustaining momentum against top-tier competition in the National League West, yet they remain a club with the potential to cause trouble for even the strongest teams when their lineup and pitching staff click together at the right time, and facing a divisional foe like San Diego provides both a measuring stick and an opportunity to make up crucial ground in the standings. Offensively, Arizona has leaned heavily on the bat of Corbin Carroll, whose combination of speed, contact hitting, and developing power has given the Diamondbacks a dynamic presence at the top of the order, while Christian Walker remains the club’s steady source of middle-of-the-order power, consistently providing home run threats and extra-base hits to drive in runs. Ketel Marte’s switch-hitting ability and knack for putting the ball in play continue to serve as the glue in the batting order, helping create chances for the team to capitalize in key situations, and prospects like Jordan Lawlar and Jake McCarthy are beginning to get opportunities to contribute, offering a glimpse of both the future and additional lineup depth.
However, the Diamondbacks have often struggled with situational hitting, leaving runners stranded in scoring position at an alarming rate, which has prevented them from maximizing opportunities and has turned winnable games into frustrating losses. On the pitching side, Arizona’s ace Zac Gallen continues to be the face of the staff, a strike-thrower with a sharp breaking ball and the poise to pitch deep into games, but behind him the rotation has been spotty, with Merrill Kelly providing flashes of quality but struggling to stay healthy and the back end often relying on young arms still adjusting to the grind of MLB lineups. The bullpen remains a sore spot for the team, as blown saves and late-inning collapses have haunted them, putting added pressure on the offense to generate large leads that can survive those mistakes, though there have been improvements from relievers like Kevin Ginkel and Paul Sewald, who provide some late-game reliability when used carefully. Defensively, Arizona has athleticism across the diamond, with Carroll’s range in the outfield and Lawlar’s improving glove at shortstop giving them stability, yet lapses in fundamentals have occasionally cost them. As they head into this matchup with San Diego, the Diamondbacks know they must control the running game, limit free passes, and make the most of scoring opportunities against a formidable Padres staff that rarely gives up easy runs, and the coaching staff will be emphasizing execution, discipline at the plate, and keeping games close enough to allow their stars to make a difference. This series carries added weight not just because of the standings, but also because Arizona’s young roster must demonstrate growth, resilience, and the ability to compete consistently under pressure, and if Carroll, Walker, and Gallen lead the way, the Diamondbacks could transform this matchup into a chance to reassert themselves in the divisional race, proving that they are not simply a team developing for the future but one capable of creating problems for contenders in the present.

Credit: USA TODAY/IMAGN
San Diego Padres MLB Preview
The San Diego Padres enter this contest against the Arizona Diamondbacks with high expectations and the pressure of delivering on a roster that has been built to win now, featuring both established stars and younger talent in a competitive NL West environment where every divisional series carries postseason implications, and with the Padres still aiming to solidify their playoff position, this matchup represents a crucial opportunity to assert dominance over a team that has long been trying to climb into contention. At the heart of San Diego’s offensive attack is Fernando Tatis Jr., who continues to be one of the most electric players in the league with his combination of power, speed, and flair that ignites the lineup, while Juan Soto’s blend of patience and slugging ability makes him an on-base machine capable of changing the game with a single swing. Manny Machado provides the steady veteran presence, offering both leadership and consistent production, while players like Xander Bogaerts and Jake Cronenworth round out a lineup that is as deep as it is versatile, giving manager Mike Shildt the ability to adapt based on pitching matchups. The Padres have shown the ability to produce explosive offensive outbursts, particularly when they string together quality at-bats and force opposing pitchers into stressful situations, but at times their lineup has gone cold, leading to frustrating droughts in close games.
On the mound, San Diego continues to rely heavily on Yu Darvish’s veteran craftiness, the high-velocity arsenal of Joe Musgrove when healthy, and the developing consistency of Michael King, who has stepped into a larger role, while the bullpen has emerged as a key strength with Robert Suarez locking down saves and setup men like Adrian Morejon and Yuki Matsui providing quality innings in high-leverage situations. One of the Padres’ biggest assets is their ability to shorten games with strong late-inning relief, which has been particularly important in close divisional battles where every mistake can swing momentum. Defensively, the Padres are one of the sharper units in baseball, with Tatis Jr. showcasing his elite athleticism in the outfield, Machado’s Gold Glove-level defense anchoring third base, and Ha-Seong Kim bringing versatility and range to the infield, giving San Diego the ability to turn potential rallies into quick outs. As they prepare to host the Diamondbacks, the Padres know they have to guard against complacency, as Arizona’s young talent is more than capable of punishing lapses in execution, and Shildt will emphasize the need to apply pressure early, control the tempo of the game, and avoid allowing Arizona to hang around late where bullpen swings can prove costly. San Diego’s challenge has often been maintaining focus over a long season, but in a series like this, their experience, depth, and star power position them as clear favorites, provided they can back up their talent with consistent execution. With the home crowd behind them at Petco Park and the stakes continuing to rise as the postseason approaches, the Padres have the chance to not only secure another divisional win but also reinforce their status as one of the most dangerous teams in the National League when everything is clicking.
Final. pic.twitter.com/qJaLGizmGQ
— San Diego Padres (@Padres) September 24, 2025
Arizona vs. San Diego Prop Picks (AI)
Arizona vs. San Diego Prediction (AI)

Remi, our AI sports algorithm, has been pouring over mountains of data from every angle between the Diamondbacks and Padres and using recursive machine learning and kick-ass AI to examine the data to a single cover probability.
Remi has been most watching on the trending weight knucklehead sportsbettors tend to put on San Diego’s strength factors between a Diamondbacks team going up against a possibly unhealthy Padres team. Trends look to say the true game analytics appear to reflect a moderate lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Arizona vs San Diego picks, computer picks Diamondbacks vs Padres, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 3 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | CIN@LAD | GET FREE PICK NOW | 1 | – | |
MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 0 |
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MLB | 10/1 | BOS@NYY | GET FREE PICK NOW | 0 | – |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Diamondbacks Betting Trends
The Arizona Diamondbacks have struggled against the spread recently, covering just three of their last nine games as inconsistency from their rotation has hurt them late.
Padres Betting Trends
The San Diego Padres have been steadier at Petco Park, covering in five of their last seven home games behind strong outings from their veteran core.
Diamondbacks vs. Padres Matchup Trends
Interestingly, six of the last ten meetings between these two teams have gone over the total, as both lineups tend to produce fireworks when they meet despite Petco Park’s reputation as a pitcher-friendly stadium.
Arizona vs. San Diego Game Info
What time does Arizona vs San Diego start on September 26, 2025?
Arizona vs San Diego starts on September 26, 2025 at 9:40 PM EST.
Where is Arizona vs San Diego being played?
Venue: Petco Park.
What are the opening odds for Arizona vs San Diego?
Spread: San Diego -1.5
Moneyline: Arizona +122, San Diego -147
Over/Under: 7.5
What are the records for Arizona vs San Diego?
Arizona: (80-79) | San Diego: (87-72)
What is the AI best bet for Arizona vs San Diego?
Remi's searched hard and found the best prop for this matchup: J. Merrill over 5.5 Fantasy Score.. Prices move—always shop for the best number.
What are Arizona vs San Diego trending bets?
Interestingly, six of the last ten meetings between these two teams have gone over the total, as both lineups tend to produce fireworks when they meet despite Petco Park’s reputation as a pitcher-friendly stadium.
What are Arizona trending bets?
ARI trend: The Arizona Diamondbacks have struggled against the spread recently, covering just three of their last nine games as inconsistency from their rotation has hurt them late.
What are San Diego trending bets?
SD trend: The San Diego Padres have been steadier at Petco Park, covering in five of their last seven home games behind strong outings from their veteran core.
Where can I find AI Picks for Arizona vs San Diego?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Arizona vs. San Diego Odds
AI algorithm Remi is pouring through tons of data on each player. In fact, anytime the Arizona vs San Diego trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance seemingly never follow normal, predictable betting trends.
Arizona vs San Diego Opening Odds
ARI Moneyline:
+122 SD Moneyline: -147
ARI Spread: +1.5
SD Spread: -1.5
Over/Under: 7.5
Arizona vs San Diego Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
|
–
–
|
+100
-120
|
-1.5 (+175)
+1.5 (-215)
|
O 7 (-105)
U 7 (-115)
|
|
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
|
–
–
|
+100
-118
|
-1.5 (+172)
+1.5 (-210)
|
O 7.5 (-110)
U 7.5 (-110)
|
|
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
|
–
–
|
+136
-162
|
+1.5 (-160)
-1.5 (+130)
|
O 7.5 (-120)
U 7.5 (-102)
|
|
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
|
–
–
|
+110
-130
|
pk
pk
|
|
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Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
|
–
–
|
+108
-126
|
pk
pk
|
O 7 (-135)
U 7 (+115)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Arizona Diamondbacks vs. San Diego Padres on September 26, 2025 at Petco Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |