The September 24, 2025 matchup between the New York Mets and the Chicago Cubs at Wrigley Field promises to be a pivotal late-season clash where one team fights for survival and the other works to sharpen its playoff readiness, and that difference in motivation could shape the way the game unfolds. The Cubs, entrenched in the postseason picture and enjoying one of their best stretches of consistency in years, will look to lean on the steady production of Nico Hoerner, Seiya Suzuki, and Christopher Morel while also counting on their starting pitcher to deliver a quality outing that keeps their bullpen fresh for October. Their rotation has been one of their biggest strengths down the stretch, and with a bullpen that has become more reliable in high-leverage spots, manager Craig Counsell has the flexibility to aggressively manage late innings in close contests. The Mets, meanwhile, arrive in Chicago with desperation fueling them, knowing they have little room for error in the Wild Card chase, and will need standout efforts from stars like Pete Alonso and Juan Soto to generate offense against a Cubs staff that does not give away much at home.

Francisco Lindor’s presence at shortstop is equally critical, not just for his defense but also for his ability to provide balance in the lineup and deliver in clutch moments, something the Mets will need if they’re to quiet a Cubs crowd that thrives on momentum swings. On the mound, David Peterson is expected to get the ball for New York, and his command will be tested early, as the Cubs are patient enough to work counts and punish mistakes, which could force the Mets into their bullpen too soon if he struggles. New York’s relief corps has been shaky at times, and in a hitter-friendly environment like Wrigley where the wind can change everything, their ability to limit damage and avoid implosions will be crucial. Defensively, both teams will need to be sharp, as miscues have been costly in prior matchups between these clubs, but the pressure is especially on the Mets, as unforced errors could bury them in a game they cannot afford to lose. From a betting standpoint, the Cubs are deservedly moneyline favorites around -145, reflecting both their form and home-field advantage, while the Mets sit as underdogs at +125 with some appeal on the +1.5 run line if Peterson can keep the game close. The total is set near 9 runs, a number that reflects the volatility of Wrigley games—leaning over if the wind aids the ball’s carry or if bullpens falter, but under if the starters are sharp and control the tempo. Ultimately, this matchup comes down to execution: the Cubs can afford to play their steady brand of baseball and trust their depth, while the Mets must play their best, cleanest game of the season and hope their stars rise to the occasion. If Chicago continues its balance of power, pitching, and discipline, they should hold serve at home, but if the Mets ride urgency and big moments from their stars, this game could serve as a statement win in their push to extend their season.