Tigers vs. Guardians
Prediction, Odds & Props
Sep 24 | MLB AI Picks
Updated: 2025-09-22T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Detroit Tigers travel to face the Cleveland Guardians on September 24, 2025, in a high-stakes Central division showdown as both clubs are scrambling for positioning in the final stretch. With Cleveland riding a hot streak and Detroit trying to reestablish its dominance after a brutal slump, this game could have ripple effects on postseason seeding.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 24, 2025
Start Time: 6:40 PM EST
Venue: Progressive Field
Guardians Record: (85-72)
Tigers Record: (85-72)
OPENING ODDS
DET Moneyline: +105
CLE Moneyline: -124
DET Spread: +1.5
CLE Spread: -1.5
Over/Under: 7.5
DET
Betting Trends
- Detroit has had mixed results against the spread on the road this season, especially against elite AL Central rivals, with some covers but also notable fade in tough matchups as their pitching has sometimes faltered under pressure. Their record vs. Cleveland this year is 4–3, so bettors have seen some value when the matchups align, but they’ve also been vulnerable in close games.
CLE
Betting Trends
- Cleveland has been strong at home this season, particularly in high-leverage games, often covering modest spreads when their pitching is in form and bullpen is healthy. Their recent surge in wins and improved bullpen consistency have bolstered confidence among bettors in home matchups.
MATCHUP TRENDS
- Oddsmakers peg Detroit as a moderate road underdog and Cleveland as a slim favorite at home, with a likely moneyline edge for the Guardians. The run line of –1.5 for Cleveland could carry value if their ace delivers, and the over/under is expected to be around 8.5 runs, reflecting the potential for offense if either starter slips. Historically, games between these teams tend to feature tight bullpen battles and decisive middle innings, so value may lie in the run line or total rather than moneyline alone.
DET vs. CLE
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: T. Bibee under 34.5 Fantasy Score.
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Detroit vs Cleveland Prediction & Odds:
Free MLB Betting Insights for 9/24/25
Guardians starters have shown the ability to suppress power while keeping games close, and with their bullpen tightening up in recent weeks, manager Stephen Vogt has been able to manage aggressively in late innings, playing matchups to his advantage. Defensively, Cleveland remains one of the sharper clubs in the division, capable of cutting off rallies with crisp execution and avoiding the kinds of mistakes that have plagued Detroit in recent series. From a betting standpoint, the Guardians are favored on the moneyline at home, reflecting their current form and the Tigers’ uneven play, while the run line at -1.5 offers value if Cleveland’s offense continues its trend of punishing mistakes in the middle innings. Detroit, however, has shown the ability to cover the +1.5 run line if their pitching holds and their stars produce timely hits, making them a dangerous underdog despite their struggles. The total of 8.5 runs could go either way depending on whether the pitchers settle in or if the offenses exploit mistakes, but the intensity of a divisional rivalry often leads to unpredictable scoring patterns. Ultimately, this matchup hinges on whether the Tigers can shake off their slump and play clean, aggressive baseball on the road, or whether the Guardians can continue riding their hot streak to tighten their grip on the division and further demoralize a Detroit team running out of time to rediscover its form.
RILEY DOUBLES THE LEAD 💥 pic.twitter.com/ZtvQlqMog0
— Detroit Tigers (@tigers) September 24, 2025
Detroit Tigers MLB Preview
The Detroit Tigers head into Progressive Field on September 24, 2025, desperate to halt a late-season slide that has put their playoff hopes in jeopardy and shifted momentum in the AL Central toward Cleveland, and this matchup against the Guardians gives them a chance to make a statement that they still belong in the postseason conversation. Detroit’s offense has been inconsistent at best, as Spencer Torkelson and Riley Greene remain the cornerstones of the lineup but have lacked sustained support from the rest of the order, leaving the Tigers prone to scoring droughts and missed opportunities with runners in scoring position. For the Tigers to compete, their starting pitcher must deliver a quality outing—working deep into the game, limiting free passes, and keeping the ball in the park—because exposing their shaky bullpen too early has been a recipe for disaster in recent weeks. Defensively, Detroit must avoid the lapses that have repeatedly cost them games, as extra outs against a Guardians team that thrives on situational hitting and pressure tactics can quickly turn into multi-run innings.
Manager A.J. Hinch will need to manage aggressively, mixing small ball with timely hitting to manufacture runs against a Cleveland staff that has been stingy of late. From a betting perspective, the Tigers are underdogs on the moneyline but offer some value on the +1.5 run line if their starter can keep things close and the offense delivers even modest production, while the total of 8.5 runs could lean under if Detroit’s pitching stabilizes, though the over might cash if their bullpen unravels late. Ultimately, the Tigers’ formula is straightforward but difficult: get strong starting pitching, count on Torkelson and Greene to spark the offense, play clean defensively, and avoid overexposing their relievers, because anything less could lead to another frustrating loss that further erodes their grip on the playoff race.

Credit: USA TODAY/IMAGN
Cleveland Guardians MLB Preview
The Cleveland Guardians enter their September 24, 2025 clash with the Detroit Tigers at Progressive Field riding a wave of late-season momentum and fully aware that a win here could further solidify their push toward the postseason while simultaneously dealing a crushing blow to a divisional rival that has stumbled at the wrong time. Cleveland’s formula for success has been steady pitching, sharp defense, and timely hitting, and they will look to continue that blueprint in front of a home crowd eager to see them seize control of the AL Central race. On the mound, the Guardians are expected to lean on one of their young arms—likely Gavin Williams or Tanner Bibee—who has shown the ability to limit hard contact, work deep into games, and keep the bullpen fresh, which has been critical during their recent surge. Offensively, José Ramírez remains the spark plug and centerpiece of the lineup, combining power with patience, while Steven Kwan’s ability to reach base and set the table has made him one of the most valuable leadoff hitters in the division, and the emergence of George Valera has provided another layer of production to keep opposing pitchers honest.
Defensively, Cleveland has been one of the cleanest teams in the league, avoiding costly miscues that extend innings and consistently converting routine plays into outs, which is a stark contrast to Detroit’s struggles in the field. Manager Stephen Vogt has also benefited from a bullpen that has rounded into form at the right time, with high-leverage arms delivering consistency in closing out games, giving the Guardians a distinct edge if they carry a lead into the late innings. From a betting perspective, Cleveland enters as the moneyline favorite, with additional appeal on the -1.5 run line if their starter sets the tone and their offense capitalizes on Detroit’s shaky pitching depth, while the total of 8.5 runs could lean under if both pitching staffs perform, though the over remains viable if the Guardians’ bats exploit Detroit’s bullpen. Ultimately, Cleveland’s path to victory lies in executing the same disciplined, opportunistic baseball that has carried them on this hot streak: get solid innings from their starter, lean on Ramírez and Kwan to drive the offense, and trust their bullpen to close the door. If they stick to that script, the Guardians should be in prime position to extend their surge and further expose a Detroit team that has struggled to handle the pressure of September baseball.
Bring 'em up. Set 'em down. 😮💨#GuardsBall | #GuardiWins pic.twitter.com/vkibBqoa4a
— Cleveland Guardians (@CleGuardians) September 24, 2025
Detroit vs. Cleveland Prop Picks (AI)
Detroit vs. Cleveland Prediction (AI)

Remi, our AI sports genius, has been pouring over mountains of data from every simulation between the Tigers and Guardians and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.
Remi has been most fixated on the linear correlation of weight knucklehead sportsbettors often put on Cleveland’s strength factors between a Tigers team going up against a possibly improved Guardians team. It appears the true game analytics appear to reflect a strong lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Detroit vs Cleveland picks, computer picks Tigers vs Guardians, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 3 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | CIN@LAD | GET FREE PICK NOW | 1 | – | |
MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 0 |
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MLB | 10/1 | BOS@NYY | GET FREE PICK NOW | 0 | – |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Tigers Betting Trends
Detroit has had mixed results against the spread on the road this season, especially against elite AL Central rivals, with some covers but also notable fade in tough matchups as their pitching has sometimes faltered under pressure. Their record vs. Cleveland this year is 4–3, so bettors have seen some value when the matchups align, but they’ve also been vulnerable in close games.
Guardians Betting Trends
Cleveland has been strong at home this season, particularly in high-leverage games, often covering modest spreads when their pitching is in form and bullpen is healthy. Their recent surge in wins and improved bullpen consistency have bolstered confidence among bettors in home matchups.
Tigers vs. Guardians Matchup Trends
Oddsmakers peg Detroit as a moderate road underdog and Cleveland as a slim favorite at home, with a likely moneyline edge for the Guardians. The run line of –1.5 for Cleveland could carry value if their ace delivers, and the over/under is expected to be around 8.5 runs, reflecting the potential for offense if either starter slips. Historically, games between these teams tend to feature tight bullpen battles and decisive middle innings, so value may lie in the run line or total rather than moneyline alone.
Detroit vs. Cleveland Game Info
What time does Detroit vs Cleveland start on September 24, 2025?
Detroit vs Cleveland starts on September 24, 2025 at 6:40 PM EST.
Where is Detroit vs Cleveland being played?
Venue: Progressive Field.
What are the opening odds for Detroit vs Cleveland?
Spread: Cleveland -1.5
Moneyline: Detroit +105, Cleveland -124
Over/Under: 7.5
What are the records for Detroit vs Cleveland?
Detroit: (85-72) | Cleveland: (85-72)
What is the AI best bet for Detroit vs Cleveland?
Remi's searched hard and found the best prop for this matchup: T. Bibee under 34.5 Fantasy Score.. Prices move—always shop for the best number.
What are Detroit vs Cleveland trending bets?
Oddsmakers peg Detroit as a moderate road underdog and Cleveland as a slim favorite at home, with a likely moneyline edge for the Guardians. The run line of –1.5 for Cleveland could carry value if their ace delivers, and the over/under is expected to be around 8.5 runs, reflecting the potential for offense if either starter slips. Historically, games between these teams tend to feature tight bullpen battles and decisive middle innings, so value may lie in the run line or total rather than moneyline alone.
What are Detroit trending bets?
DET trend: Detroit has had mixed results against the spread on the road this season, especially against elite AL Central rivals, with some covers but also notable fade in tough matchups as their pitching has sometimes faltered under pressure. Their record vs. Cleveland this year is 4–3, so bettors have seen some value when the matchups align, but they’ve also been vulnerable in close games.
What are Cleveland trending bets?
CLE trend: Cleveland has been strong at home this season, particularly in high-leverage games, often covering modest spreads when their pitching is in form and bullpen is healthy. Their recent surge in wins and improved bullpen consistency have bolstered confidence among bettors in home matchups.
Where can I find AI Picks for Detroit vs Cleveland?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Detroit vs. Cleveland Odds
AI algorithm Remi is pouring through mountains of data points on each player. In fact, anytime the Detroit vs Cleveland trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable betting trends.
Detroit vs Cleveland Opening Odds
DET Moneyline:
+105 CLE Moneyline: -124
DET Spread: +1.5
CLE Spread: -1.5
Over/Under: 7.5
Detroit vs Cleveland Live Odds
Games | PTS | ML | SPR | O/U | |
---|---|---|---|---|---|
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
|
–
–
|
+100
-120
|
-1.5 (+175)
+1.5 (-215)
|
O 7 (-105)
U 7 (-115)
|
|
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
|
–
–
|
+100
-118
|
-1.5 (+172)
+1.5 (-210)
|
O 7.5 (-110)
U 7.5 (-110)
|
|
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
|
–
–
|
+136
-162
|
+1.5 (-160)
-1.5 (+130)
|
O 7.5 (-120)
U 7.5 (-102)
|
|
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
|
–
–
|
+110
-130
|
pk
pk
|
|
|
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
|
–
–
|
+108
-126
|
pk
pk
|
O 7 (-135)
U 7 (+115)
|
MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Detroit Tigers vs. Cleveland Guardians on September 24, 2025 at Progressive Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |