Tigers vs. Guardians
Prediction, Odds & Props
Sep 24 | MLB AI Picks

Updated: 2025-09-22T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Detroit Tigers travel to face the Cleveland Guardians on September 24, 2025, in a high-stakes Central division showdown as both clubs are scrambling for positioning in the final stretch. With Cleveland riding a hot streak and Detroit trying to reestablish its dominance after a brutal slump, this game could have ripple effects on postseason seeding.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 24, 2025

Start Time: 6:40 PM EST​

Venue: Progressive Field​

Guardians Record: (85-72)

Tigers Record: (85-72)

OPENING ODDS

DET Moneyline: +105

CLE Moneyline: -124

DET Spread: +1.5

CLE Spread: -1.5

Over/Under: 7.5

DET
Betting Trends

  • Detroit has had mixed results against the spread on the road this season, especially against elite AL Central rivals, with some covers but also notable fade in tough matchups as their pitching has sometimes faltered under pressure. Their record vs. Cleveland this year is 4–3, so bettors have seen some value when the matchups align, but they’ve also been vulnerable in close games.

CLE
Betting Trends

  • Cleveland has been strong at home this season, particularly in high-leverage games, often covering modest spreads when their pitching is in form and bullpen is healthy. Their recent surge in wins and improved bullpen consistency have bolstered confidence among bettors in home matchups.

MATCHUP TRENDS

  • Oddsmakers peg Detroit as a moderate road underdog and Cleveland as a slim favorite at home, with a likely moneyline edge for the Guardians. The run line of –1.5 for Cleveland could carry value if their ace delivers, and the over/under is expected to be around 8.5 runs, reflecting the potential for offense if either starter slips. Historically, games between these teams tend to feature tight bullpen battles and decisive middle innings, so value may lie in the run line or total rather than moneyline alone.

DET vs. CLE
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: T. Bibee under 34.5 Fantasy Score.

LIVE MLB ODDS

MLB ODDS COMPARISON

WANT MORE AI PICKS?

VAULT
VS. SPREAD
310-227
VAULT
NET UNITS
(INCL VIG)
+390.9
VAULT
NET PROFIT
(INCL VIG)
$100/UNIT
$39,086
EXECUTIVE
VS. SPREAD
1564-1335
EXECUTIVE
NET UNITS
(INCL VIG)
+387.3
EXECUTIVE
NET PROFIT
(INCL VIG)
$100/UNIT
$38,728

AI SPORTS PICK PRODUCTS

Create a Free Account

‘Create an Account’ to Get Remi’s Picks Today.

Remi Finds New Picks

Remi calculates the probability a team will cover the line.

Remi Works 24/7

Remi uses this probability to assign units to each pick.

Get Remi's AI Picks

Get Remi’s Top AI Sports Picks sent direct to your inbox.

Detroit vs Cleveland Prediction & Odds:
Free MLB Betting Insights for 9/24/25

The September 24, 2025 matchup between the Detroit Tigers and the Cleveland Guardians at Progressive Field is shaping up to be one of the most intriguing late-season contests in the American League Central, as both teams are not only bitter division rivals but also playing for meaningful stakes with postseason implications. Detroit, who not long ago appeared in firm control of their own playoff destiny, has been dragged back to the pack by a poorly timed slump that has seen their offense sputter and their bullpen spring leaks, while Cleveland, riding a surge of hot play and improved consistency, has closed the gap and positioned itself as a genuine contender to leapfrog their rivals in the standings. The Tigers will lean heavily on their young core of Spencer Torkelson and Riley Greene to provide run production, but the pressure on their starting pitching staff is equally immense, as any short outings or early damage could expose a bullpen that has been unreliable in tight contests. Detroit’s path to victory lies in early offense, taking the crowd out of the game, and receiving at least six strong innings from their starter to minimize bullpen exposure, but that will be difficult against a Guardians team that thrives in high-contact, high-pressure situations. Cleveland, for its part, has built its surge around the consistent play of José Ramírez, the speed and table-setting ability of Steven Kwan, and the timely contributions of emerging bats like George Valera, all supported by a pitching staff that has rounded into form down the stretch.

Guardians starters have shown the ability to suppress power while keeping games close, and with their bullpen tightening up in recent weeks, manager Stephen Vogt has been able to manage aggressively in late innings, playing matchups to his advantage. Defensively, Cleveland remains one of the sharper clubs in the division, capable of cutting off rallies with crisp execution and avoiding the kinds of mistakes that have plagued Detroit in recent series. From a betting standpoint, the Guardians are favored on the moneyline at home, reflecting their current form and the Tigers’ uneven play, while the run line at -1.5 offers value if Cleveland’s offense continues its trend of punishing mistakes in the middle innings. Detroit, however, has shown the ability to cover the +1.5 run line if their pitching holds and their stars produce timely hits, making them a dangerous underdog despite their struggles. The total of 8.5 runs could go either way depending on whether the pitchers settle in or if the offenses exploit mistakes, but the intensity of a divisional rivalry often leads to unpredictable scoring patterns. Ultimately, this matchup hinges on whether the Tigers can shake off their slump and play clean, aggressive baseball on the road, or whether the Guardians can continue riding their hot streak to tighten their grip on the division and further demoralize a Detroit team running out of time to rediscover its form.

Detroit Tigers MLB Preview

The Detroit Tigers head into Progressive Field on September 24, 2025, desperate to halt a late-season slide that has put their playoff hopes in jeopardy and shifted momentum in the AL Central toward Cleveland, and this matchup against the Guardians gives them a chance to make a statement that they still belong in the postseason conversation. Detroit’s offense has been inconsistent at best, as Spencer Torkelson and Riley Greene remain the cornerstones of the lineup but have lacked sustained support from the rest of the order, leaving the Tigers prone to scoring droughts and missed opportunities with runners in scoring position. For the Tigers to compete, their starting pitcher must deliver a quality outing—working deep into the game, limiting free passes, and keeping the ball in the park—because exposing their shaky bullpen too early has been a recipe for disaster in recent weeks. Defensively, Detroit must avoid the lapses that have repeatedly cost them games, as extra outs against a Guardians team that thrives on situational hitting and pressure tactics can quickly turn into multi-run innings.

Manager A.J. Hinch will need to manage aggressively, mixing small ball with timely hitting to manufacture runs against a Cleveland staff that has been stingy of late. From a betting perspective, the Tigers are underdogs on the moneyline but offer some value on the +1.5 run line if their starter can keep things close and the offense delivers even modest production, while the total of 8.5 runs could lean under if Detroit’s pitching stabilizes, though the over might cash if their bullpen unravels late. Ultimately, the Tigers’ formula is straightforward but difficult: get strong starting pitching, count on Torkelson and Greene to spark the offense, play clean defensively, and avoid overexposing their relievers, because anything less could lead to another frustrating loss that further erodes their grip on the playoff race.

The Detroit Tigers travel to face the Cleveland Guardians on September 24, 2025, in a high-stakes Central division showdown as both clubs are scrambling for positioning in the final stretch. With Cleveland riding a hot streak and Detroit trying to reestablish its dominance after a brutal slump, this game could have ripple effects on postseason seeding. Detroit vs Cleveland AI Prediction: Free MLB Betting Insights for Sep 24. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Cleveland Guardians MLB Preview

The Cleveland Guardians enter their September 24, 2025 clash with the Detroit Tigers at Progressive Field riding a wave of late-season momentum and fully aware that a win here could further solidify their push toward the postseason while simultaneously dealing a crushing blow to a divisional rival that has stumbled at the wrong time. Cleveland’s formula for success has been steady pitching, sharp defense, and timely hitting, and they will look to continue that blueprint in front of a home crowd eager to see them seize control of the AL Central race. On the mound, the Guardians are expected to lean on one of their young arms—likely Gavin Williams or Tanner Bibee—who has shown the ability to limit hard contact, work deep into games, and keep the bullpen fresh, which has been critical during their recent surge. Offensively, José Ramírez remains the spark plug and centerpiece of the lineup, combining power with patience, while Steven Kwan’s ability to reach base and set the table has made him one of the most valuable leadoff hitters in the division, and the emergence of George Valera has provided another layer of production to keep opposing pitchers honest.

Defensively, Cleveland has been one of the cleanest teams in the league, avoiding costly miscues that extend innings and consistently converting routine plays into outs, which is a stark contrast to Detroit’s struggles in the field. Manager Stephen Vogt has also benefited from a bullpen that has rounded into form at the right time, with high-leverage arms delivering consistency in closing out games, giving the Guardians a distinct edge if they carry a lead into the late innings. From a betting perspective, Cleveland enters as the moneyline favorite, with additional appeal on the -1.5 run line if their starter sets the tone and their offense capitalizes on Detroit’s shaky pitching depth, while the total of 8.5 runs could lean under if both pitching staffs perform, though the over remains viable if the Guardians’ bats exploit Detroit’s bullpen. Ultimately, Cleveland’s path to victory lies in executing the same disciplined, opportunistic baseball that has carried them on this hot streak: get solid innings from their starter, lean on Ramírez and Kwan to drive the offense, and trust their bullpen to close the door. If they stick to that script, the Guardians should be in prime position to extend their surge and further expose a Detroit team that has struggled to handle the pressure of September baseball.

Detroit vs. Cleveland Prop Picks (AI)

AI algorithm Remi is pouring through loads of stats on each team. In fact, anytime the Tigers and Guardians play there’s always several intriguing angles to key in on. Not to mention games played at Progressive Field in Sep rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: T. Bibee under 34.5 Fantasy Score.

Detroit vs. Cleveland Prediction (AI)

Remi Robot Icon

Remi, our AI sports genius, has been pouring over mountains of data from every simulation between the Tigers and Guardians and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.

Remi has been most fixated on the linear correlation of weight knucklehead sportsbettors often put on Cleveland’s strength factors between a Tigers team going up against a possibly improved Guardians team. It appears the true game analytics appear to reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Detroit vs Cleveland picks, computer picks Tigers vs Guardians, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 BOS@NYY UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 CIN@LAD GET FREE PICK NOW 1
MLB 10/1 BOS@NYY UNLOCK THIS PICK 0 INTEL Locked INTEL
MLB 10/1 BOS@NYY GET FREE PICK NOW 0

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Tigers Betting Trends

Detroit has had mixed results against the spread on the road this season, especially against elite AL Central rivals, with some covers but also notable fade in tough matchups as their pitching has sometimes faltered under pressure. Their record vs. Cleveland this year is 4–3, so bettors have seen some value when the matchups align, but they’ve also been vulnerable in close games.

Guardians Betting Trends

Cleveland has been strong at home this season, particularly in high-leverage games, often covering modest spreads when their pitching is in form and bullpen is healthy. Their recent surge in wins and improved bullpen consistency have bolstered confidence among bettors in home matchups.

Tigers vs. Guardians Matchup Trends

Oddsmakers peg Detroit as a moderate road underdog and Cleveland as a slim favorite at home, with a likely moneyline edge for the Guardians. The run line of –1.5 for Cleveland could carry value if their ace delivers, and the over/under is expected to be around 8.5 runs, reflecting the potential for offense if either starter slips. Historically, games between these teams tend to feature tight bullpen battles and decisive middle innings, so value may lie in the run line or total rather than moneyline alone.

Detroit vs. Cleveland Game Info

Detroit vs Cleveland starts on September 24, 2025 at 6:40 PM EST.

Spread: Cleveland -1.5
Moneyline: Detroit +105, Cleveland -124
Over/Under: 7.5

Detroit: (85-72)  |  Cleveland: (85-72)

Remi's searched hard and found the best prop for this matchup: T. Bibee under 34.5 Fantasy Score.. Prices move—always shop for the best number.

Oddsmakers peg Detroit as a moderate road underdog and Cleveland as a slim favorite at home, with a likely moneyline edge for the Guardians. The run line of –1.5 for Cleveland could carry value if their ace delivers, and the over/under is expected to be around 8.5 runs, reflecting the potential for offense if either starter slips. Historically, games between these teams tend to feature tight bullpen battles and decisive middle innings, so value may lie in the run line or total rather than moneyline alone.

DET trend: Detroit has had mixed results against the spread on the road this season, especially against elite AL Central rivals, with some covers but also notable fade in tough matchups as their pitching has sometimes faltered under pressure. Their record vs. Cleveland this year is 4–3, so bettors have seen some value when the matchups align, but they’ve also been vulnerable in close games.

CLE trend: Cleveland has been strong at home this season, particularly in high-leverage games, often covering modest spreads when their pitching is in form and bullpen is healthy. Their recent surge in wins and improved bullpen consistency have bolstered confidence among bettors in home matchups.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Detroit vs. Cleveland Odds

AI algorithm Remi is pouring through mountains of data points on each player. In fact, anytime the Detroit vs Cleveland trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable betting trends.

Detroit vs Cleveland Opening Odds

DET Moneyline: +105
CLE Moneyline: -124
DET Spread: +1.5
CLE Spread: -1.5
Over/Under: 7.5

Detroit vs Cleveland Live Odds

Games PTS ML SPR O/U
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
+100
-120
-1.5 (+175)
+1.5 (-215)
O 7 (-105)
U 7 (-115)
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
+100
-118
-1.5 (+172)
+1.5 (-210)
O 7.5 (-110)
U 7.5 (-110)
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
+136
-162
+1.5 (-160)
-1.5 (+130)
O 7.5 (-120)
U 7.5 (-102)
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
+110
-130
pk
pk
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
+108
-126
pk
pk
O 7 (-135)
U 7 (+115)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Detroit Tigers vs. Cleveland Guardians on September 24, 2025 at Progressive Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS