Rays vs. Orioles
Prediction, Odds & Props
Sep 23 | MLB AI Picks

Updated: 2025-09-21T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Rays visit Camden Yards to wrap up their series against the Orioles, riding on offensive heat runs and bullpen reliability, while Baltimore hopes to leverage home energy and recent momentum to make up ground in the standings. Tampa Bay enters as a slight favorite, but Baltimore—backed by reactivated Adley Rutschman and an offense that’s shown flashes—has enough tools to make this far from a cakewalk.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 23, 2025

Start Time: 6:35 PM EST​

Venue: Oriole Park at Camden Yards​

Orioles Record: (73-83)

Rays Record: (76-80)

OPENING ODDS

TB Moneyline: -114

BAL Moneyline: -105

TB Spread: -1.5

BAL Spread: +1.5

Over/Under: 9

TB
Betting Trends

  • Tampa Bay has entered 78 games this season as a favorite and won 44 of those, a win rate of about 56.4%. When favored by around -117, they’ve also been able to win 37 of 65 such games, showing moderate consistency when moneyline expectations are on their shoulders. Their road spreads have been hit or miss; while they win many of those matchups, covering by large margins can be shaky.

BAL
Betting Trends

  • The Orioles have often been underdogs this season—89 games where their moneyline implied they were the underdog—and won 40 of those, giving them a 44.9% success rate in such situations. Against the run line, Baltimore has struggled more; their ATS record on that front has shown negative units over many games, especially when facing stronger offenses or teams with momentum like the Rays.

MATCHUP TRENDS

  • The total for this game is set around 9 runs, suggesting oddsmakers expect a moderately high-scoring affair. Tampa Bay is favored on the run line (-1.5), which implies expectations of them winning by at least two runs, though their ability to cover that has varied. The Orioles’ underdog wins and the Rays’ tendency to win as favorites but sometimes underperform ATS when expectations are high suggest there may be value in taking Baltimore +1.5 if the line is generous—or in targeting player props or under on totals if Baltimore’s pitching holds stronger than expected.

TB vs. BAL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: S. Basallo over 4.5 Fantasy Score.

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Tampa Bay vs Baltimore Prediction & Odds:
Free MLB Betting Insights for 9/23/25

The September 23, 2025 matchup between the Tampa Bay Rays and the Baltimore Orioles at Camden Yards sets up as one of those intriguing late-season clashes where both teams have plenty on the line, and the outcome could carry weight in the playoff picture. Tampa Bay enters as a slight favorite thanks to its deeper roster and proven ability to win games where they’re expected to, carrying a record of winning over half the time when favored this season, though their ability to cover the run line in those situations has been less consistent. The Rays will look to lean on their offense, which has been effective at manufacturing runs through a balance of power hitting and situational execution, while their bullpen has been reliable in protecting narrow leads, making them difficult to topple when ahead late. Baltimore, meanwhile, has been fighting hard in the underdog role, winning just under 45% of games when they aren’t favored, which reflects both the challenges they’ve faced and their resilience in stealing wins against stronger competition. The Orioles’ return of Adley Rutschman has sparked the lineup and given the team a steadying influence both behind the plate and in the batter’s box, while young stars like Gunnar Henderson and Jackson Holliday continue to develop into key contributors who can change the complexion of games with big swings or sharp defensive plays.

The pitching matchup will be critical, as Baltimore’s rotation has struggled at times with command and depth, and they cannot afford to give Tampa Bay early momentum that could force their bullpen into longer work than it can reliably handle. For the Rays, efficiency from their starter and continued dominance from their bullpen will be the formula, but avoiding complacency against a team that thrives in the spoiler role will be just as important. From a betting perspective, Tampa Bay’s consistency makes them the more logical favorite, though their shaky record in covering spreads suggests bettors should be cautious about expecting a blowout. Baltimore’s home-field advantage, recent injection of energy with Rutschman’s return, and their occasional ability to play above their weight in front of their fans add intrigue, particularly for those looking at run line value or totals, as both offenses have enough talent to push scoring higher than expected. Ultimately, this game feels like a test of Tampa Bay’s ability to assert itself against a feisty opponent and Baltimore’s resolve to turn small edges into a meaningful victory, making it a contest where execution in the middle innings and bullpen stability in the late innings will almost certainly decide the outcome.

Tampa Bay Rays MLB Preview

The Tampa Bay Rays enter Camden Yards on September 23, 2025, carrying with them the steady consistency that has made them one of the most difficult teams to handle when playing from ahead, and while they come into this matchup as slight favorites against the Baltimore Orioles, they understand that maintaining sharp execution on the road will be essential if they want to leave Baltimore with another victory in their pocket. The Rays have historically performed well in games where they are listed as favorites, winning more than half of those contests, but their run-line record has been less reliable, which is why this particular game emphasizes not just winning but creating enough separation to keep late innings stress-free. Tampa Bay’s formula has been clear throughout the season: their offense is built around balance rather than relying solely on power, with hitters like Yandy Díaz, Junior Caminero, and Randy Arozarena providing both thump and the ability to extend innings by drawing walks, putting balls in play, and pressuring defenses. Against Baltimore’s pitching staff, which has struggled with depth and consistency, the Rays will need to focus on patient at-bats that drive pitch counts higher and force the Orioles to turn to their bullpen earlier than planned. If they can string together quality plate appearances and cash in runners in scoring position, the Rays should be able to create the kind of steady pressure that wears down opponents over nine innings. On the pitching side, Tampa Bay’s starter will need to deliver a solid outing by attacking the strike zone, limiting base traffic, and keeping Baltimore’s young bats from gaining confidence early, because the Orioles thrive on momentum swings and can quickly turn a game around if given opportunities.

Tampa Bay’s bullpen is one of their strongest assets, often shutting the door late, but the goal will be to ensure those relievers enter in situations where the margin for error is comfortable rather than razor thin, particularly in a hostile environment like Camden Yards. Defensively, the Rays have generally been crisp, but they must maintain that standard because mistakes against the Orioles’ lineup, especially with players like Gunnar Henderson and Adley Rutschman back in action, can snowball into extended innings. Tampa Bay also benefits from a roster that embraces versatility, with multiple players able to slot into different roles depending on matchups, which allows manager Kevin Cash to maximize platoon advantages late in games. From a betting perspective, the Rays remain a strong moneyline option thanks to their consistency, but because they sometimes play down to the score and rely heavily on their bullpen to secure narrow wins, bettors may hesitate to back them confidently on the run line. Still, their ability to control tempo, grind down opposing starters, and protect slim leads gives them a favorable outlook in this matchup, provided they do not allow Baltimore to seize early momentum. In the end, the Rays’ path to victory lies in disciplined at-bats, efficient pitching, and clean defense, and if they execute those fundamentals, they will continue to look like the type of team capable of contending deep into October while also showcasing the resilience needed to grind out tough road wins like this one in Baltimore.

The Rays visit Camden Yards to wrap up their series against the Orioles, riding on offensive heat runs and bullpen reliability, while Baltimore hopes to leverage home energy and recent momentum to make up ground in the standings. Tampa Bay enters as a slight favorite, but Baltimore—backed by reactivated Adley Rutschman and an offense that’s shown flashes—has enough tools to make this far from a cakewalk. Tampa Bay vs Baltimore AI Prediction: Free MLB Betting Insights for Sep 23. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Baltimore Orioles MLB Preview

The Baltimore Orioles take the field at Camden Yards on September 23, 2025, with a clear understanding that this game against the Tampa Bay Rays is more than just another contest in the standings—it is an opportunity to demonstrate resilience, defend their home turf, and show that even against a polished opponent they can rise to the challenge and deliver the kind of performance that energizes both the clubhouse and the fan base. Baltimore has spent much of the season battling inconsistency, particularly when asked to win as an underdog, but they have also proven that in the right circumstances they are capable of pulling off surprising victories, having won just under 45 percent of their games when not favored, which underscores their ability to fight above their weight class when urgency is high. The return of Adley Rutschman has given the Orioles a boost not only with his steady bat but also with his leadership behind the plate, guiding a pitching staff that has often struggled with depth and command issues and helping to stabilize defensive alignments in crucial innings. Alongside Rutschman, young talents like Gunnar Henderson and Jackson Holliday represent the heart of Baltimore’s future, and both have shown flashes of brilliance that can tilt games in the Orioles’ favor, whether through clutch extra-base hits, smart baserunning, or highlight-reel defensive plays that swing momentum.

To compete with the Rays, Baltimore’s offense must be opportunistic, taking advantage of every free pass and defensive lapse, because Tampa Bay’s pitching and defense are typically disciplined and unforgiving; that means capitalizing on runners in scoring position is not optional but mandatory if the Orioles hope to keep pace. The pitching staff, meanwhile, faces the tall task of limiting a Rays lineup that thrives on grinding at-bats and forcing high pitch counts, so starters like Dean Kremer or Kyle Bradish must throw strikes early, get ahead in counts, and avoid the kinds of prolonged innings that wear them down and force the bullpen into overuse. Baltimore’s bullpen has been a mixed bag, with some arms capable of shutting down innings and others more vulnerable to giving up big swings, so maintaining command and poise in the late frames will be a central factor if the game is still close heading into the seventh or eighth inning. Defensively, the Orioles must play a clean game, because against a disciplined team like Tampa Bay, errors or mental lapses will almost certainly be converted into runs, and those kinds of mistakes can turn a competitive contest into an uphill battle. From a betting perspective, Baltimore remains a risky play on the moneyline, but their ability to keep games close and feed off the energy of their home crowd at Camden Yards can make them intriguing on the run line if oddsmakers set expectations too heavily in Tampa Bay’s favor. Ultimately, the Orioles’ path to victory is straightforward but demanding: they must get a steady outing from their starter, find timely hits from both their stars and role players, execute cleanly on defense, and avoid the kind of bullpen collapse that has plagued them in tight games. If they accomplish those goals, they will give themselves every chance to steal a win against a formidable Rays team, reassert their ability to compete with playoff-caliber opponents, and perhaps spark a late-season surge that keeps their fans believing in the promise of this roster.

Tampa Bay vs. Baltimore Prop Picks (AI)

AI algorithm Remi is pouring through tons of data on each line. In fact, anytime the Rays and Orioles play there’s always several intriguing angles to key in on. Not to mention games played at Oriole Park at Camden Yards in Sep seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: S. Basallo over 4.5 Fantasy Score.

Tampa Bay vs. Baltimore Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every facet between the Rays and Orioles and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.

Remi has been most fixated on the growing weight human bettors tend to put on Tampa Bay’s strength factors between a Rays team going up against a possibly improved Orioles team. It appears the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Tampa Bay vs Baltimore picks, computer picks Rays vs Orioles, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
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MLB 10/1 DET@CLE UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 BOS@NYY UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 CIN@LAD GET FREE PICK NOW 1
MLB 10/1 BOS@NYY UNLOCK THIS PICK 0 INTEL Locked INTEL
MLB 10/1 BOS@NYY GET FREE PICK NOW 0

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Rays Betting Trends

Tampa Bay has entered 78 games this season as a favorite and won 44 of those, a win rate of about 56.4%. When favored by around -117, they’ve also been able to win 37 of 65 such games, showing moderate consistency when moneyline expectations are on their shoulders. Their road spreads have been hit or miss; while they win many of those matchups, covering by large margins can be shaky.

Orioles Betting Trends

The Orioles have often been underdogs this season—89 games where their moneyline implied they were the underdog—and won 40 of those, giving them a 44.9% success rate in such situations. Against the run line, Baltimore has struggled more; their ATS record on that front has shown negative units over many games, especially when facing stronger offenses or teams with momentum like the Rays.

Rays vs. Orioles Matchup Trends

The total for this game is set around 9 runs, suggesting oddsmakers expect a moderately high-scoring affair. Tampa Bay is favored on the run line (-1.5), which implies expectations of them winning by at least two runs, though their ability to cover that has varied. The Orioles’ underdog wins and the Rays’ tendency to win as favorites but sometimes underperform ATS when expectations are high suggest there may be value in taking Baltimore +1.5 if the line is generous—or in targeting player props or under on totals if Baltimore’s pitching holds stronger than expected.

Tampa Bay vs. Baltimore Game Info

Tampa Bay vs Baltimore starts on September 23, 2025 at 6:35 PM EST.

Venue: Oriole Park at Camden Yards.

Spread: Baltimore +1.5
Moneyline: Tampa Bay -114, Baltimore -105
Over/Under: 9

Tampa Bay: (76-80)  |  Baltimore: (73-83)

Remi's searched hard and found the best prop for this matchup: S. Basallo over 4.5 Fantasy Score.. Prices move—always shop for the best number.

The total for this game is set around 9 runs, suggesting oddsmakers expect a moderately high-scoring affair. Tampa Bay is favored on the run line (-1.5), which implies expectations of them winning by at least two runs, though their ability to cover that has varied. The Orioles’ underdog wins and the Rays’ tendency to win as favorites but sometimes underperform ATS when expectations are high suggest there may be value in taking Baltimore +1.5 if the line is generous—or in targeting player props or under on totals if Baltimore’s pitching holds stronger than expected.

TB trend: Tampa Bay has entered 78 games this season as a favorite and won 44 of those, a win rate of about 56.4%. When favored by around -117, they’ve also been able to win 37 of 65 such games, showing moderate consistency when moneyline expectations are on their shoulders. Their road spreads have been hit or miss; while they win many of those matchups, covering by large margins can be shaky.

BAL trend: The Orioles have often been underdogs this season—89 games where their moneyline implied they were the underdog—and won 40 of those, giving them a 44.9% success rate in such situations. Against the run line, Baltimore has struggled more; their ATS record on that front has shown negative units over many games, especially when facing stronger offenses or teams with momentum like the Rays.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Tampa Bay vs. Baltimore Odds

Remi is pouring through mountains of data on each line. In fact, anytime the Tampa Bay vs Baltimore trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable patterns.

Tampa Bay vs Baltimore Opening Odds

TB Moneyline: -114
BAL Moneyline: -105
TB Spread: -1.5
BAL Spread: +1.5
Over/Under: 9

Tampa Bay vs Baltimore Live Odds

Games PTS ML SPR O/U
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
+100
-120
-1.5 (+175)
+1.5 (-215)
O 7 (-105)
U 7 (-115)
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
+100
-118
-1.5 (+172)
+1.5 (-210)
O 7.5 (-110)
U 7.5 (-110)
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
+136
-162
+1.5 (-160)
-1.5 (+130)
O 7.5 (-120)
U 7.5 (-102)
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
+110
-130
pk
pk
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
+108
-126
pk
pk
O 7 (-135)
U 7 (+115)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Tampa Bay Rays vs. Baltimore Orioles on September 23, 2025 at Oriole Park at Camden Yards.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS