Dodgers vs. Diamondbacks
Prediction, Odds & Props
Sep 23 | MLB AI Picks

Updated: 2025-09-21T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Dodgers roll into Chase Field to face the Diamondbacks, looking to tighten their hold on a top seed in the NL West and maintain momentum as the postseason nears, while Arizona is still clawing for a Wild Card spot and needs wins at home to stay relevant in a crowded field. With Corbin Carroll having just become the first D-backs player this season to hit 30 home runs and steal 30 bases, Arizona has a spark, but Los Angeles’s depth and recent form still make them a heavy favorite.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 23, 2025

Start Time: 9:40 PM EST​

Venue: Chase Field​

Diamondbacks Record: (79-77)

Dodgers Record: (88-68)

OPENING ODDS

LAD Moneyline: -162

ARI Moneyline: +134

LAD Spread: -1.5

ARI Spread: +1.5

Over/Under: 9

LAD
Betting Trends

  • Los Angeles has been unpredictable against the run line this season; while their overall record is strong, their ability to cover large spreads has been spotty, particularly at home against Arizona historically, where they are 37-45 all-time versus the run line. On the road, their recent starts have been more balanced: their last 12 road games saw them go 6-6 against the run line, showing some erosion in reliability when away from home.

ARI
Betting Trends

  • Arizona has shown flashes of value, especially in games where they are underdogs and the public underestimates them, which has allowed them to pull off surprise wins. Their performance in close games at home has been one of their strengths, especially when backed by their young core and power hitters taking advantage of opponent pitching mistakes.

MATCHUP TRENDS

  • Dodgers vs. Diamondbacks matchups tend to generate moderate to high scoring; totals lines are often set around 8.5 runs, reflecting both offenses’ ability to capitalize on spending mistakes or bullpen fatigue. As favorites, the Dodgers win a high percentage of moneyline games, especially when favored by tighter margins (-160 or shorter), but they also have a history of failing to cover when the spread gets large, especially at home vs. hard-hitting rivals. Arizona’s potential upset value is amplified by the recent contributions of players like Corbin Carroll and Eduardo Rodríguez, who have shown they can swing games in Arizona’s favor. Betting edges may lie with picking Arizona +1.5 or even the over if the starting pitchers struggle early.

LAD vs. ARI
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: S. Ohtani over 10.5 Fantasy Score.

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Los Angeles vs Arizona Prediction & Odds:
Free MLB Betting Insights for 9/23/25

The September 23, 2025 matchup between the Los Angeles Dodgers and the Arizona Diamondbacks at Chase Field is a compelling late-season divisional showdown that highlights two clubs with very different but equally pressing motivations, as the Dodgers arrive looking to cement their postseason seeding and maintain momentum while the Diamondbacks are fighting to keep their Wild Card hopes alive and need every win they can get. For Los Angeles, this game is about discipline and depth, as their lineup has consistently been one of the most feared in the league, with star hitters who blend power and patience to punish mistakes and wear down opposing pitchers; their starting pitching and bullpen, while not flawless, have generally given them stability in high-leverage spots, and manager Dave Roberts will be looking for sharp execution from his rotation to ensure his bullpen enters October in good form. Arizona, on the other hand, is banking on the spark provided by Corbin Carroll, who has become the franchise’s first 30-30 player with 30 homers and 30 steals, signaling both his star potential and the energy he can bring to the offense, while players like Christian Walker and Ketel Marte give the lineup additional thump and balance, making them capable of stringing together big innings if Dodgers pitchers lose command.

The pitching matchup looms large: Arizona’s starter will need to neutralize the Dodgers’ early-game explosiveness, avoiding free passes and home-run pitches, while the bullpen has to protect any lead or keep the game close into the late innings, which has been an Achilles’ heel for them at times this season. Los Angeles’s starter will be tasked with keeping Carroll off base, as his speed and aggressive baserunning create havoc, while minimizing damage from the middle of Arizona’s order, because if the Diamondbacks seize momentum at home, they have shown the ability to ride that energy to upset wins. Defensively, both teams know that mistakes could swing the game—Arizona must be sharp to keep pressure off their pitching staff, while Los Angeles will need to avoid the kind of lapses that give the D-backs extra chances in what figures to be a high-stakes contest. From a betting perspective, the Dodgers are the clear moneyline favorites, but their history of struggling to cover the run line against Arizona suggests that bettors may find more value on the D-backs keeping it close, especially at home, while the total near 8.5 runs reflects the potential for both lineups to generate offense if starting pitching falters. Ultimately, this game will be decided by whether the Dodgers’ experience, depth, and consistency can overpower a Diamondbacks team fighting for survival, or whether Arizona’s urgency, Carroll’s spark, and the comfort of Chase Field will allow them to deliver one of their most important wins of the season.

Los Angeles Dodgers MLB Preview

The Los Angeles Dodgers head into Chase Field on September 23, 2025, with confidence and urgency as they look to fine-tune their form ahead of the postseason while also keeping their grip on seeding in a tight National League race, and although they have the advantage on paper, they know Arizona’s desperation makes the Diamondbacks a dangerous opponent. Offensively, the Dodgers remain one of the most balanced and punishing lineups in baseball, with stars capable of producing in every situation, whether it’s through long balls, extra-base hits, or patient at-bats that drive up pitch counts and create opportunities to break games open. Their biggest priority in this matchup will be to start strong, silencing the Chase Field crowd and avoiding the kind of slow beginnings that let Arizona’s offense build confidence, because once Corbin Carroll and Ketel Marte get on base, the Diamondbacks have the tools to flip momentum quickly.

On the pitching side, the Dodgers need their starter to be efficient and composed, attacking the strike zone and minimizing walks, because Arizona thrives when handed free opportunities, and their speed on the bases can create chaos. The bullpen, which has been tested in close games all year, must continue to find rhythm, as Roberts will want reliable late-inning arms heading into October, and a clean performance here would be another step toward stabilizing roles for the postseason. Defensively, Los Angeles must stay sharp, as Arizona will look to exploit any lapses with aggressive baserunning and situational hitting. From a betting standpoint, the Dodgers are clear favorites on the moneyline, but their history of failing to consistently cover the run line against Arizona suggests bettors may prefer them simply to win rather than win big, while the over has appeal if both lineups pressure opposing pitchers. Ultimately, the Dodgers’ formula is straightforward: lean on their stars for offense, get a quality start, and use their superior bullpen depth to close things out. If they stick to that blueprint, they should come away with another road win, though they know the D-backs’ urgency and home-field energy will make this a test of discipline as much as talent.

The Dodgers roll into Chase Field to face the Diamondbacks, looking to tighten their hold on a top seed in the NL West and maintain momentum as the postseason nears, while Arizona is still clawing for a Wild Card spot and needs wins at home to stay relevant in a crowded field. With Corbin Carroll having just become the first D-backs player this season to hit 30 home runs and steal 30 bases, Arizona has a spark, but Los Angeles’s depth and recent form still make them a heavy favorite. Los Angeles vs Arizona AI Prediction: Free MLB Betting Insights for Sep 23. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Arizona Diamondbacks MLB Preview

The Arizona Diamondbacks welcome the Los Angeles Dodgers to Chase Field on September 23, 2025, knowing they enter as underdogs but with the motivation of a team fighting to keep its Wild Card hopes alive and a fan base eager to see them rise to the challenge against one of baseball’s powerhouses. Arizona’s offense has been powered all season by the electrifying play of Corbin Carroll, who just became the franchise’s first-ever 30-30 player, a milestone that underscores both his ability to impact games with power and speed and his status as the face of the club’s future. Around him, the D-backs have complementary pieces like Ketel Marte, Christian Walker, and Gabriel Moreno, who provide the lineup with enough balance to pressure opposing pitchers if they can string together quality at-bats. For Arizona to succeed, their starting pitcher must set the tone by attacking the strike zone and keeping the Dodgers’ big bats from dictating early, because falling behind quickly to Los Angeles almost always leads to a snowball effect. The bullpen, often a source of late-game stress, will be under the microscope in this one, as keeping the game close into the seventh and eighth innings will be critical, giving Carroll and the offense opportunities to capitalize late.

Defensively, Arizona must play a clean game, as errors and lapses have often been their undoing in tight contests, especially against a team like the Dodgers that rarely fails to take advantage of extra outs. From a betting perspective, Arizona provides value on the run line, particularly at +1.5, given their tendency to play the Dodgers tighter than expected, especially at home, and the over is also attractive with the potential for both offenses to produce runs if starters falter. The Diamondbacks’ formula is clear: limit free passes, maximize Carroll’s speed and ability to get on base, lean on power bats to deliver a timely extra-base hit, and avoid bullpen implosions in the late innings. If they can manage all of that, they could pull off one of their most important wins of the year and continue their push toward October, but anything less will likely see the Dodgers’ depth and discipline overwhelm them in front of their own fans.

Los Angeles vs. Arizona Prop Picks (AI)

Remi is pouring through mountains of datapoints on each line. In fact, anytime the Dodgers and Diamondbacks play there’s always several intriguing angles to key in on. Not to mention games played at Chase Field in Sep rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: S. Ohtani over 10.5 Fantasy Score.

Los Angeles vs. Arizona Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over mountains of data from every simulation between the Dodgers and Diamondbacks and using recursive machine learning and industry leading AI to analyze the data to a single cover probability.

Remi has been most keyed in on the trending emphasis human bettors tend to put on coaching factors between a Dodgers team going up against a possibly strong Diamondbacks team. It appears the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Los Angeles vs Arizona picks, computer picks Dodgers vs Diamondbacks, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 BOS@NYY UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 CIN@LAD GET FREE PICK NOW 1
MLB 10/1 BOS@NYY UNLOCK THIS PICK 0 INTEL Locked INTEL
MLB 10/1 BOS@NYY GET FREE PICK NOW 0

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Dodgers Betting Trends

Los Angeles has been unpredictable against the run line this season; while their overall record is strong, their ability to cover large spreads has been spotty, particularly at home against Arizona historically, where they are 37-45 all-time versus the run line. On the road, their recent starts have been more balanced: their last 12 road games saw them go 6-6 against the run line, showing some erosion in reliability when away from home.

Diamondbacks Betting Trends

Arizona has shown flashes of value, especially in games where they are underdogs and the public underestimates them, which has allowed them to pull off surprise wins. Their performance in close games at home has been one of their strengths, especially when backed by their young core and power hitters taking advantage of opponent pitching mistakes.

Dodgers vs. Diamondbacks Matchup Trends

Dodgers vs. Diamondbacks matchups tend to generate moderate to high scoring; totals lines are often set around 8.5 runs, reflecting both offenses’ ability to capitalize on spending mistakes or bullpen fatigue. As favorites, the Dodgers win a high percentage of moneyline games, especially when favored by tighter margins (-160 or shorter), but they also have a history of failing to cover when the spread gets large, especially at home vs. hard-hitting rivals. Arizona’s potential upset value is amplified by the recent contributions of players like Corbin Carroll and Eduardo Rodríguez, who have shown they can swing games in Arizona’s favor. Betting edges may lie with picking Arizona +1.5 or even the over if the starting pitchers struggle early.

Los Angeles vs. Arizona Game Info

Los Angeles vs Arizona starts on September 23, 2025 at 9:40 PM EST.

Spread: Arizona +1.5
Moneyline: Los Angeles -162, Arizona +134
Over/Under: 9

Los Angeles: (88-68)  |  Arizona: (79-77)

Remi's searched hard and found the best prop for this matchup: S. Ohtani over 10.5 Fantasy Score.. Prices move—always shop for the best number.

Dodgers vs. Diamondbacks matchups tend to generate moderate to high scoring; totals lines are often set around 8.5 runs, reflecting both offenses’ ability to capitalize on spending mistakes or bullpen fatigue. As favorites, the Dodgers win a high percentage of moneyline games, especially when favored by tighter margins (-160 or shorter), but they also have a history of failing to cover when the spread gets large, especially at home vs. hard-hitting rivals. Arizona’s potential upset value is amplified by the recent contributions of players like Corbin Carroll and Eduardo Rodríguez, who have shown they can swing games in Arizona’s favor. Betting edges may lie with picking Arizona +1.5 or even the over if the starting pitchers struggle early.

LAD trend: Los Angeles has been unpredictable against the run line this season; while their overall record is strong, their ability to cover large spreads has been spotty, particularly at home against Arizona historically, where they are 37-45 all-time versus the run line. On the road, their recent starts have been more balanced: their last 12 road games saw them go 6-6 against the run line, showing some erosion in reliability when away from home.

ARI trend: Arizona has shown flashes of value, especially in games where they are underdogs and the public underestimates them, which has allowed them to pull off surprise wins. Their performance in close games at home has been one of their strengths, especially when backed by their young core and power hitters taking advantage of opponent pitching mistakes.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Los Angeles vs. Arizona Odds

Remi is pouring through mountains of data on each player. In fact, anytime the Los Angeles vs Arizona trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps almost always follow normal, predictable betting trends.

Los Angeles vs Arizona Opening Odds

LAD Moneyline: -162
ARI Moneyline: +134
LAD Spread: -1.5
ARI Spread: +1.5
Over/Under: 9

Los Angeles vs Arizona Live Odds

Games PTS ML SPR O/U
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
+100
-120
-1.5 (+175)
+1.5 (-215)
O 7 (-105)
U 7 (-115)
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
+100
-118
-1.5 (+172)
+1.5 (-210)
O 7.5 (-110)
U 7.5 (-110)
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
+136
-162
+1.5 (-160)
-1.5 (+130)
O 7.5 (-120)
U 7.5 (-102)
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
+110
-130
pk
pk
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
+108
-126
pk
pk
O 7 (-135)
U 7 (+115)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Los Angeles Dodgers vs. Arizona Diamondbacks on September 23, 2025 at Chase Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS