Cardinals vs. Giants
FREE MLB AI Predictions
September 22, 2025
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 22, 2025
Start Time: 9:45 PM EST​
Venue: ​
Giants Record:
Cardinals Record:
OPENING ODDS
STL Moneyline:
SF Moneyline:
STL Spread:
SF Spread:
Over/Under:
STL
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SF
Betting Trends
MATCHUP TRENDS
STL vs. SF
Best Prop Bet
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St. Louis vs San Francisco AI Prediction:
Free MLB Betting Insights for 9/22/25
Cardinals AI Preview
Credit: USA TODAY/IMAGN
Giants AI Preview
Cardinals vs. Giants FREE Prop Pick
Remi is pouring through mountains of data on each team. In fact, anytime the Cardinals and Giants play there’s always several intriguing trends to key in on. Not to mention games played at in Sep can often follow normal, predictable patterns.
St. Louis vs. San Francisco MLB AI Pick
Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every angle between the Cardinals and Giants and using recursive machine learning and impressive AI to crunch the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most fixated on the trending emphasis knucklehead sportsbettors regularly put on coaching factors between a Cardinals team going up against a possibly rested Giants team. Trends look to say the true game analytics appear to reflect a moderate lean against one Vegas line specifically.
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